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Aliases for TRUB2 Gene

Aliases for TRUB2 Gene

  • TruB Pseudouridine Synthase Family Member 2 2 3 5
  • TruB Pseudouridine (Psi) Synthase Family Member 2 2 3
  • TruB Pseudouridine (Psi) Synthase Homolog 2 (E. Coli) 2
  • TruB Pseudouridine (Psi) Synthase Homolog 2 3
  • Probable TRNA Pseudouridine Synthase 2 3
  • EC 5.4.99.- 4
  • CLONE24922 3

External Ids for TRUB2 Gene

Previous GeneCards Identifiers for TRUB2 Gene

  • GC09U990211
  • GC09M126447
  • GC09M128150
  • GC09M130111
  • GC09M131071
  • GC09M100684

Summaries for TRUB2 Gene

Entrez Gene Summary for TRUB2 Gene

  • Pseudouridine is an abundant component of rRNAs and tRNAs and is enzymatically generated by isomerization of uridine by pseudouridine synthase (Zucchini et al., 2003 [PubMed 12736709]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TRUB2 Gene

TRUB2 (TruB Pseudouridine Synthase Family Member 2) is a Protein Coding gene. Diseases associated with TRUB2 include Dyskeratosis Congenita. GO annotations related to this gene include poly(A) RNA binding and pseudouridine synthase activity. An important paralog of this gene is TRUB1.

UniProtKB/Swiss-Prot for TRUB2 Gene

  • May be responsible for synthesis of pseudouridine from uracil in transfer RNAs.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRUB2 Gene

Genomics for TRUB2 Gene

Regulatory Elements for TRUB2 Gene

Enhancers for TRUB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G128321 1.1 ENCODE 0.7 -0.1 -147 3.3 HDGF PKNOX1 ZFP64 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B URM1 ZNF79 COQ4 TRUB2 TRR-TCT3-1
GH09G128328 0.8 ENCODE 0.4 -6.4 -6399 2.0 HDAC1 ESRRA KLF1 INSM2 CEBPG ZIC2 HIC1 POLR2A ZNF366 ZBTB48 URM1 TRUB2 TRR-TCT3-1
GH09G128332 0.7 ENCODE 0.4 -10.8 -10782 1.2 ZNF263 CTCF KLF1 ZNF777 MAZ ZNF398 REST ZIC2 GLIS1 KLF9 URM1 TRR-TCT3-1 TRUB2
GH09G128340 0.5 ENCODE 0.4 -16.7 -16655 0.1 ZNF121 GATA3 ZNF362 TRR-TCT3-1 TRUB2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRUB2 on UCSC Golden Path with GeneCards custom track

Promoters for TRUB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000241858 -58 2001 HDGF PKNOX1 ZFP64 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B

Genomic Location for TRUB2 Gene

Chromosome:
9
Start:
128,305,161 bp from pter
End:
128,322,742 bp from pter
Size:
17,582 bases
Orientation:
Minus strand

Genomic View for TRUB2 Gene

Genes around TRUB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRUB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRUB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRUB2 Gene

Proteins for TRUB2 Gene

  • Protein details for TRUB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95900-TRUB2_HUMAN
    Recommended name:
    Probable tRNA pseudouridine synthase 2
    Protein Accession:
    O95900
    Secondary Accessions:
    • B7Z7G5

    Protein attributes for TRUB2 Gene

    Size:
    331 amino acids
    Molecular mass:
    36694 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRUB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRUB2 Gene

Post-translational modifications for TRUB2 Gene

  • Ubiquitination at posLast=3636
  • Modification sites at PhosphoSitePlus

Other Protein References for TRUB2 Gene

No data available for DME Specific Peptides for TRUB2 Gene

Domains & Families for TRUB2 Gene

Protein Domains for TRUB2 Gene

Graphical View of Domain Structure for InterPro Entry

O95900

UniProtKB/Swiss-Prot:

TRUB2_HUMAN :
  • Belongs to the pseudouridine synthase TruB family.
Family:
  • Belongs to the pseudouridine synthase TruB family.
genes like me logo Genes that share domains with TRUB2: view

No data available for Gene Families for TRUB2 Gene

Function for TRUB2 Gene

Molecular function for TRUB2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
tRNA uridine = tRNA pseudouridine.
UniProtKB/Swiss-Prot Function:
May be responsible for synthesis of pseudouridine from uracil in transfer RNAs.

Enzyme Numbers (IUBMB) for TRUB2 Gene

Gene Ontology (GO) - Molecular Function for TRUB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0009982 pseudouridine synthase activity IEA --
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with TRUB2: view
genes like me logo Genes that share phenotypes with TRUB2: view

Animal Models for TRUB2 Gene

MGI Knock Outs for TRUB2:

Animal Model Products

CRISPR Products

miRNA for TRUB2 Gene

miRTarBase miRNAs that target TRUB2

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRUB2 Gene

Localization for TRUB2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRUB2 gene
Compartment Confidence
cytosol 5
mitochondrion 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TRUB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with TRUB2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRUB2 Gene

Pathways & Interactions for TRUB2 Gene

SuperPathways for TRUB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRUB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001522 pseudouridine synthesis IEA --
GO:0006396 RNA processing IEA --
GO:0008033 tRNA processing IEA --
GO:0009451 RNA modification IEA --
genes like me logo Genes that share ontologies with TRUB2: view

No data available for Pathways by source and SIGNOR curated interactions for TRUB2 Gene

Drugs & Compounds for TRUB2 Gene

(1) Additional Compounds for TRUB2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pseudouridine
  • 5-(b-D-Ribofuranosyl)uracil
  • 5-(b-delta-Ribofuranosyl)uracil
  • 5-b-D-Ribofuranosyl-Uracil
  • 5-beta-delta-Ribofuranosyl-Uracil
  • 5-Ribosyluracil
1445-07-4
genes like me logo Genes that share compounds with TRUB2: view

Transcripts for TRUB2 Gene

Unigene Clusters for TRUB2 Gene

TruB pseudouridine (psi) synthase homolog 2 (E. coli):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRUB2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: - -
SP2: - - -
SP3:
SP4:

Relevant External Links for TRUB2 Gene

GeneLoc Exon Structure for
TRUB2
ECgene alternative splicing isoforms for
TRUB2

Expression for TRUB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRUB2 Gene

Protein differential expression in normal tissues from HIPED for TRUB2 Gene

This gene is overexpressed in Heart (58.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRUB2 Gene



Protein tissue co-expression partners for TRUB2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRUB2 Gene:

TRUB2

SOURCE GeneReport for Unigene cluster for TRUB2 Gene:

Hs.632685

Evidence on tissue expression from TISSUES for TRUB2 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with TRUB2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRUB2 Gene

Orthologs for TRUB2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRUB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRUB2 34 35
  • 99.09 (n)
dog
(Canis familiaris)
Mammalia TRUB2 34 35
  • 84.14 (n)
cow
(Bos Taurus)
Mammalia TRUB2 34 35
  • 82.72 (n)
mouse
(Mus musculus)
Mammalia Trub2 34 16 35
  • 81.37 (n)
rat
(Rattus norvegicus)
Mammalia Trub2 34
  • 79.18 (n)
oppossum
(Monodelphis domestica)
Mammalia TRUB2 35
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRUB2 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRUB2 34 35
  • 62.06 (n)
lizard
(Anolis carolinensis)
Reptilia TRUB2 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trub2 34
  • 63.64 (n)
Str.15106 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.13716 34
zebrafish
(Danio rerio)
Actinopterygii trub2 34 35
  • 58.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7849 34 35
  • 47.13 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002077 34
  • 46.34 (n)
worm
(Caenorhabditis elegans)
Secernentea Y43B11AR.3 35
  • 21 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUS4 35
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
OneToOne
Species where no ortholog for TRUB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRUB2 Gene

ENSEMBL:
Gene Tree for TRUB2 (if available)
TreeFam:
Gene Tree for TRUB2 (if available)

Paralogs for TRUB2 Gene

Paralogs for TRUB2 Gene

genes like me logo Genes that share paralogs with TRUB2: view

Variants for TRUB2 Gene

Sequence variations from dbSNP and Humsavar for TRUB2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs758522459 Pathogenic 128,323,147(+) GCCAC(C/G)GTAAG nc-transcript-variant, upstream-variant-2KB, reference, missense
rs766317663 Pathogenic 128,323,135(+) ATAAC(C/T)CCTAC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs786204770 Pathogenic 128,323,100(-) CGGCC(A/G)ACAGC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs886041549 Pathogenic 128,322,881(+) CCCTG(-/TCCTCCGTCGG)CTCTG nc-transcript-variant, upstream-variant-2KB, reference, frameshift-variant
rs1000053586 -- 128,313,390(+) AAAAA(G/T)CCGGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRUB2 Gene

Variant ID Type Subtype PubMed ID
nsv1132225 CNV deletion 24896259
nsv831728 CNV loss 17160897

Variation tolerance for TRUB2 Gene

Residual Variation Intolerance Score: 85.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.75; 46.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRUB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRUB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRUB2 Gene

Disorders for TRUB2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRUB2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
dyskeratosis congenita
  • zinsser-cole-engman syndrome
- elite association - COSMIC cancer census association via MalaCards
Search TRUB2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TRUB2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRUB2
genes like me logo Genes that share disorders with TRUB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRUB2 Gene

Publications for TRUB2 Gene

  1. The human TruB family of pseudouridine synthase genes, including the Dyskeratosis Congenita 1 gene and the novel member TRUB1. (PMID: 12736709) Zucchini C. … Valvassori L. (Int. J. Mol. Med. 2003) 2 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd B.J. … Pagliarini D.J. (Mol. Cell 2016) 3 64

Products for TRUB2 Gene

Sources for TRUB2 Gene

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