Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TRUB2 Gene

protein-coding   GIFtS: 53
GCID: GC09M131071

TruB Pseudouridine (Psi) Synthase Family Member 2

(Previous name: TruB pseudouridine (psi) synthase homolog 2 (E. coli))
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
TruB Pseudouridine (Psi) Synthase Family Member 21 2
TruB Pseudouridine (Psi) Synthase Homolog 2 (E. Coli)1
CLONE249222
Probable TRNA Pseudouridine Synthase 22
TruB Pseudouridine (Psi) Synthase Homolog 22
EC 5.4.99.-3

External Ids:    HGNC: 171701   Entrez Gene: 269952   Ensembl: ENSG000001671127   OMIM: 6107275   UniProtKB: O959003   

Export aliases for TRUB2 gene to outside databases

Previous GC identifers: GC09U990211 GC09M126447 GC09M128150 GC09M130111 GC09M100684


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TRUB2 Gene:
Pseudouridine is an abundant component of rRNAs and tRNAs and is enzymatically generated by isomerization of
uridine by pseudouridine synthase (Zucchini et al., 2003 (PubMed 12736709)).(supplied by OMIM, Mar 2008)

GeneCards Summary for TRUB2 Gene:
TRUB2 (TruB pseudouridine (psi) synthase family member 2) is a protein-coding gene. GO annotations related to this gene include pseudouridine synthase activity and RNA binding. An important paralog of this gene is TRUB1.

UniProtKB/Swiss-Prot: TRUB2_HUMAN, O95900
Function: May be responsible for synthesis of pseudouridine from uracil in transfer RNAs (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRUB2 gene promoter:
         NF-1   AML1a   NRSF form 1   GCNF   p300   Olf-1   NRSF form 2   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRUB2 promoter sequence
   Search Chromatin IP Primers for TRUB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRUB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.11

TRUB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRUB2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M131071:  view genomic region     (about GC identifiers)

Start:
131,071,382 bp from pter      End:
131,085,021 bp from pter
Size:
13,640 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TRUB2_HUMAN, O95900 (See protein sequence)
Recommended Name: Probable tRNA pseudouridine synthase 2  
Size: 331 amino acids; 36694 Da

Explore the universe of human proteins at neXtProt for TRUB2: NX_O95900

Explore proteomics data for TRUB2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys36
  • Modification sites at PhosphoSitePlus

  • See TRUB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056494.1  
    ENSEMBL proteins: 
     ENSP00000361982   ENSP00000438084  

    TRUB2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TRUB2
    OriGene Protein Over-expression Lysate for TRUB2
    OriGene MassSpec for TRUB2
    OriGene Custom Protein Services for TRUB2
    GenScript Custom Purified and Recombinant Proteins Services for TRUB2
    Novus Biologicals TRUB2 Protein
    Novus Biologicals TRUB2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRUB2

     
    Search eBioscience for Proteins for TRUB2 

     
    antibodies-online proteins for TRUB2 (4 products) 

     
    antibodies-online peptides for TRUB2

    TRUB2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TRUB2
    Novus Biologicals TRUB2 Antibodies
    Abcam antibodies for TRUB2
    Cloud-Clone Corp. Antibodies for TRUB2
    ThermoFisher Antibodies for TRUB2
    LSBio Antibodies in human, mouse, rat for TRUB2
    antibodies-online antibodies for TRUB2 (22 products) 

    TRUB2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TRUB2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRUB2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TRUB2
    Cloud-Clone Corp. CLIAs for TRUB2
    Search eBioscience for ELISAs for TRUB2 
    antibodies-online kits for TRUB2 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR002501 PsdUridine_synth
     IPR020103 PsdUridine_synth_cat_dom

    Graphical View of Domain Structure for InterPro Entry O95900

    ProtoNet protein and cluster: O95900

    1 Blocks protein domain: IPB002501 Pseudouridylate synthase TruB

    UniProtKB/Swiss-Prot: TRUB2_HUMAN, O95900
    Similarity: Belongs to the pseudouridine synthase TruB family


    Find genes that share domains with TRUB2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRUB2_HUMAN, O95900
    Function: May be responsible for synthesis of pseudouridine from uracil in transfer RNAs (By similarity)
    Catalytic activity: tRNA uridine = tRNA pseudouridine

         Enzyme Number (IUBMB): EC 5.4.99.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0009982pseudouridine synthase activity IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with TRUB2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TRUB2:
     Increased gamma-H2AX phosphory  Proliferating cells 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Trub2):
     mortality/aging 

    Find genes that share phenotypes with TRUB2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRUB2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRUB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRUB2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRUB2

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRUB2:
    hsa-mir-16-5p (MIRT031822), hsa-let-7b-5p (MIRT032411)

    Block miRNA regulation of human, mouse, rat TRUB2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate TRUB2:
    hsa-miR-22 hsa-miR-622
    SwitchGear 3'UTR luciferase reporter plasmidTRUB2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRUB2
    Predesigned siRNA for gene silencing in human, mouse, rat TRUB2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRUB2

    Clone
    Products:
         
    OriGene clones in human, mouse for TRUB2 (see all 7)
    OriGene ORF clones in mouse, rat for TRUB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRUB2 (NM_015679)
    Sino Biological Human cDNA Clone for TRUB2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRUB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRUB2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TRUB2
    Browse ESI BIO Cell Lines and PureStem Progenitors for TRUB2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRUB2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3
    cytosol1
    endoplasmic reticulum1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRUB2
    Interactions:

        Search GeneGlobe Interaction Network for TRUB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRUB2 (O959002, 3 ENSP000003619824) via UniProtKB, MINT, STRING, and/or I2D (see all 386)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    NOA1Q8NC602, ENSP000002642304MINT-8079030 STRING: ENSP00000264230
    HARS2P495902, ENSP000002307714MINT-8079030 STRING: ENSP00000230771
    MRPL3P090012, ENSP000002649954MINT-8079030 STRING: ENSP00000264995
    MTG1Q9BT172, ENSP000003230474MINT-8079030 STRING: ENSP00000323047
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001522pseudouridine synthesis IEA--
    GO:0006396RNA processing ----
    GO:0008033tRNA processing IEA--
    GO:0009451RNA modification ----

    Find genes that share ontologies with TRUB2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRUB2

    1 HMDB Compound for TRUB2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Pseudouridine5-(b-D-Ribofuranosyl)uracil (see all 12)1445-07-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TRUB2 gene: 
    NM_015679.1  

    Unigene Cluster for TRUB2:

    TruB pseudouridine (psi) synthase homolog 2 (E. coli)
    Hs.632685  [show with all ESTs]
    Unigene Representative Sequence: AK130008
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372890(uc004buq.1) ENST00000460320 ENST00000461180 ENST00000546104

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TRUB2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate TRUB2:
    hsa-miR-22 hsa-miR-622
    SwitchGear 3'UTR luciferase reporter plasmidTRUB2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TRUB2
    Predesigned siRNA for gene silencing in human, mouse, rat TRUB2
    Clone
    Products:
         
    OriGene clones in human, mouse for TRUB2 (see all 7)
    OriGene ORF clones in mouse, rat for TRUB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRUB2 (NM_015679)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRUB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRUB2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TRUB2
    OriGene qSTAR qPCR primer pairs in human, mouse for TRUB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRUB2
      QuantiTect SYBR Green Assays in human, mouse, rat TRUB2
      QuantiFast Probe-based Assays in human, mouse, rat TRUB2

    Additional mRNA sequence: 

    AF131848.1 AJ420462.1 AK001956.1 AK130008.1 AK301986.1 BC001457.2 

    10 DOTS entries:

    DT.100789460  DT.314672  DT.99958266  DT.92440679  DT.91849592  DT.40119393  DT.92440681  DT.100733341 
    DT.101958046  DT.95263226 

    Selected AceView cDNA sequences (see all 265):

    BI088178 BI755341 BM788735 BE263842 AA580342 BM465344 BF971688 CF141749 
    BE793897 BM808885 AA299565 BM836860 BM751657 AW341986 BI857763 BF794699 
    BM915751 BG677477 AL555778 BX107604 BM913329 BQ954357 T09097 AA807533 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TRUB2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
    SP1:                                -                       -                     
    SP2:                    -           -                       -                     
    SP3:                                                                              
    SP4:                                                                              


    ECgene alternative splicing isoforms for TRUB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TRUB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGACTGAT
    TRUB2 Expression
    About this image

    TRUB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRUB2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632685
        Custom PCR Arrays for TRUB2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TRUB2
    OriGene qSTAR qPCR primer pairs in human, mouse for TRUB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRUB2
    QuantiTect SYBR Green Assays in human, mouse, rat TRUB2
    QuantiFast Probe-based Assays in human, mouse, rat TRUB2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRUB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TRUB2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trub21 , 5 TruB pseudouridine (psi) synthase homolog 2 (E. coli)1, 5 81.37(n)1
    81.57(a)1
      2 (20.57 cM)5
    2276821  NM_145520.41  NP_663495.31 
     297612245 
    chicken
    (Gallus gallus)
    Aves TRUB21 TruB pseudouridine (psi) synthase homolog 2 (E. coli) 62.06(n)
    60.82(a)
      417218  XM_415502.3  XP_415502.2 
    lizard
    (Anolis carolinensis)
    Reptilia TRUB26
    TruB pseudouridine (psi) synthase family member 2
    60(a)
    1 ↔ 1
    GL343763.1(5255-17567)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.137162 Xenopus laevis transcribed sequence with weak similarity more 75.14(n)    BJ082536.1 
    zebrafish
    (Danio rerio)
    Actinopterygii trub21 TruB pseudouridine (psi) synthase homolog 2 (E. coli) 58.33(n)
    56.88(a)
      431747  NM_001002200.2  NP_001002200.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG78491 CG7849 47.13(n)
    34.07(a)
      35537  NM_136357.2  NP_610201.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y43B11AR.36
    Protein Y43B11AR.3 (Y43B11AR.3) mRNA, complete cds...
    21(a)
    1 ↔ 1
    IV(7082276-7083640) WBGene00021544
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PUS46
    Pseudouridine synthase, catalyzes only the formati...
    14(a)
    1 → many
    XIV(82806-84017) YNL292W


    ENSEMBL Gene Tree for TRUB2 (if available)
    TreeFam Gene Tree for TRUB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TRUB2 gene
    TRUB12  

    Find genes that share paralogs with TRUB2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TRUB2 (see all 316)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1928719431,2
    --131070950(+) GTCCCC/GGCCAG 1 -- ds50010--------
    rs1846055011,2
    --131071028(+) CATCTC/TGGATA 1 -- ds50010--------
    rs1463281911,2
    --131071058(+) GGTGGC/TGGGCG 1 -- ds50010--------
    rs78745041,2
    C,A--131071144(+) aagatC/Ggcgcc 1 -- ds50013Minor allele frequency- G:0.25NA CSA 4
    rs1895385861,2
    --131071146(+) GATGGC/TGCCAC 1 -- ds50010--------
    rs1475163171,2
    --131071294(+) ATTTGA/CCTAAT 1 -- ds50010--------
    rs1382470641,2
    --131071308(+) GTCGTC/TGTCTT 1 -- ds50010--------
    rs132866371,2
    C,F--131071335(+) GGCTCT/CCTGTA 1 -- ds50014Minor allele frequency- C:0.10NA 126
    rs1492739681,2
    C--131071357(+) TTAGTC/TCTTGG 1 -- ds50010--------
    rs1806831291,2
    --131071367(+) GTTAAC/TGACAC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for TRUB2 (131071382 - 131085021 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TRUB2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831728CNV Loss17160897
    dgv8294n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TRUB2
    DNA2.0 Custom Variant and Variant Library Synthesis for TRUB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 610727    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for TRUB2:
    Dyskeratosis congenita

    Find genes that share disorders with TRUB2           About GenesLikeMe


    Export disorders for TRUB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TRUB2 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with TRUB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human TruB family of pseudouridine synthase genes, including the Dyskeratosis Congenita 1 gene and the novel member TRUB1. (PubMed id 12736709)1, 2, 3, 9 Zucchini C.... Valvassori L. (Int. J. Mol. Med. 2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)
    9. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (EMBO J. 2010)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 26995 HGNC: 17170 AceView: TRUB2 Ensembl:ENSG00000167112 euGenes: HUgn26995
    ECgene: TRUB2 H-InvDB: TRUB2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TRUB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TRUB2 gene:
    Search GeneIP for patents involving TRUB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TRUB2  
     OriGene qPCR primer pairs and template standards for TRUB2   OriGene Protein Over-expression Lysate for TRUB2  
     OriGene MassSpec for TRUB2   OriGene clones in human, mouse for TRUB2  
     OriGene qSTAR qPCR primer pairs in human, mouse for TRUB2   OriGene Purified Protein for TRUB2  
     OriGene ORF clones in mouse, rat for TRUB2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TRUB2   OriGene Custom Protein Services for TRUB2  

     
     
     Block miRNA regulation of human, mouse, rat TRUB2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TRUB2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRUB2 Predesigned siRNA for gene silencing in human, mouse, rat TRUB2
     QuantiFast Probe-based Assays in human, mouse, rat TRUB2 QuantiTect SYBR Green Assays in human, mouse, rat TRUB2
     Custom PCR Arrays for TRUB2 Search Chromatin IP Primers for TRUB2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRUB2  Search GeneGlobe Interaction Network for TRUB2
     Regulatory tfbs in TRUB2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TRUB2 GenScript cDNA clones with any tag delivered in your preferred vector for TRUB2
     GenScript Custom Assay Services for TRUB2 GenScript Custom overexpressing Cell Line Services for TRUB2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TRUB2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for TRUB2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TRUB2 antibodies
     TRUB2 proteins
     TRUB2 lysates
     Antibodies for TRUB2
     See all of Abcam's Antibodies, Kits and Proteins for TRUB2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TRUB2
     Antibodies for TRUB2
     ELISAs for TRUB2
     CLIAs for TRUB2



     Browse ESI BIO Cell Lines and PureStem Progenitors for TRUB2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRUB2
     SwitchGear 3'UTR luciferase reporter plasmids for TRUB2
     SwitchGear Promoter luciferase reporter plasmids for TRUB2
     ThermoFisher Antibodies for TRUB2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRUB2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRUB2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRUB2
     LSBio Antibodies in human, mouse, rat for TRUB2
     Browse compounds at ApexBio
     Search Addgene for plasmids for TRUB2
      Search eBioscience for proteins for TRUB2
      Search eBioscience for elisas for TRUB2
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for TRUB2 (22 products)
     antibodies-online kits for TRUB2 (6 products)
     antibodies-online peptides for TRUB2
     antibodies-online proteins for TRUB2 (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TRUB2 gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4