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Aliases for TRUB2 Gene

Aliases for TRUB2 Gene

  • TruB Pseudouridine (Psi) Synthase Family Member 2 2 3
  • TruB Pseudouridine (Psi) Synthase Homolog 2 (E. Coli) 2
  • TruB Pseudouridine (Psi) Synthase Homolog 2 3
  • Probable TRNA Pseudouridine Synthase 2 3
  • EC 5.4.99.- 4
  • CLONE24922 3

External Ids for TRUB2 Gene

Previous GeneCards Identifiers for TRUB2 Gene

  • GC09U990211
  • GC09M126447
  • GC09M128150
  • GC09M130111
  • GC09M131071
  • GC09M100684

Summaries for TRUB2 Gene

Entrez Gene Summary for TRUB2 Gene

  • Pseudouridine is an abundant component of rRNAs and tRNAs and is enzymatically generated by isomerization of uridine by pseudouridine synthase (Zucchini et al., 2003 [PubMed 12736709]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TRUB2 Gene

TRUB2 (TruB Pseudouridine (Psi) Synthase Family Member 2) is a Protein Coding gene. GO annotations related to this gene include RNA binding and pseudouridine synthase activity. An important paralog of this gene is TRUB1.

UniProtKB/Swiss-Prot for TRUB2 Gene

  • May be responsible for synthesis of pseudouridine from uracil in transfer RNAs.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRUB2 Gene

Genomics for TRUB2 Gene

Regulatory Elements for TRUB2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRUB2 Gene

128,309,103 bp from pter
128,322,742 bp from pter
13,640 bases
Minus strand

Genomic View for TRUB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRUB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRUB2 Gene

Proteins for TRUB2 Gene

  • Protein details for TRUB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable tRNA pseudouridine synthase 2
    Protein Accession:
    Secondary Accessions:
    • B7Z7G5

    Protein attributes for TRUB2 Gene

    331 amino acids
    Molecular mass:
    36694 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRUB2 Gene


neXtProt entry for TRUB2 Gene

Proteomics data for TRUB2 Gene at MOPED

Post-translational modifications for TRUB2 Gene

  • Ubiquitination at Lys36
  • Modification sites at PhosphoSitePlus

Other Protein References for TRUB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRUB2 Gene

Domains for TRUB2 Gene

Protein Domains for TRUB2 Gene

Graphical View of Domain Structure for InterPro Entry



  • O95900
  • Belongs to the pseudouridine synthase TruB family.
genes like me logo Genes that share domains with TRUB2: view

No data available for Gene Families for TRUB2 Gene

Function for TRUB2 Gene

Molecular function for TRUB2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: tRNA uridine = tRNA pseudouridine
UniProtKB/Swiss-Prot Function: May be responsible for synthesis of pseudouridine from uracil in transfer RNAs.

Enzyme Numbers (IUBMB) for TRUB2 Gene

Gene Ontology (GO) - Molecular Function for TRUB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding --
GO:0009982 pseudouridine synthase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with TRUB2: view

Phenotypes for TRUB2 Gene

MGI mutant phenotypes for TRUB2:
inferred from 1 alleles
GenomeRNAi human phenotypes for TRUB2:
genes like me logo Genes that share phenotypes with TRUB2: view

Animal Model Products

CRISPR Products

miRNA for TRUB2 Gene

miRTarBase miRNAs that target TRUB2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRUB2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TRUB2 Gene

Localization for TRUB2 Gene

Subcellular locations from

Jensen Localization Image for TRUB2 Gene COMPARTMENTS Subcellular localization image for TRUB2 gene
Compartment Confidence
mitochondrion 3
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TRUB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with TRUB2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRUB2 Gene

Pathways for TRUB2 Gene

SuperPathways for TRUB2 Gene

No Data Available

Interacting Proteins for TRUB2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: O95900-TRUB2_HUMAN ENSP00000361982 for TRUB2 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for TRUB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001522 pseudouridine synthesis IEA --
GO:0006396 RNA processing IEA --
GO:0008033 tRNA processing IEA --
GO:0009451 RNA modification --
genes like me logo Genes that share ontologies with TRUB2: view

No data available for Pathways by source for TRUB2 Gene

Compounds for TRUB2 Gene

(1) HMDB Compounds for TRUB2 Gene

Compound Synonyms Cas Number PubMed IDs
  • 5-(b-D-Ribofuranosyl)uracil
genes like me logo Genes that share compounds with TRUB2: view

Transcripts for TRUB2 Gene

mRNA/cDNA for TRUB2 Gene

Unigene Clusters for TRUB2 Gene

TruB pseudouridine (psi) synthase homolog 2 (E. coli):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRUB2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRUB2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: - -
SP2: - - -

Relevant External Links for TRUB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRUB2 Gene

mRNA expression in normal human tissues for TRUB2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TRUB2 Gene

SOURCE GeneReport for Unigene cluster for TRUB2 Gene Hs.632685

genes like me logo Genes that share expressions with TRUB2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRUB2 Gene

Orthologs for TRUB2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRUB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRUB2 35
  • 99.09 (n)
  • 98.49 (a)
TRUB2 36
  • 98 (a)
(Bos Taurus)
Mammalia TRUB2 35
  • 82.72 (n)
  • 85.98 (a)
TRUB2 36
  • 86 (a)
(Canis familiaris)
Mammalia TRUB2 35
  • 84.14 (n)
  • 84.5 (a)
TRUB2 36
  • 84 (a)
(Mus musculus)
Mammalia Trub2 35
  • 81.37 (n)
  • 81.57 (a)
Trub2 16
Trub2 36
  • 82 (a)
(Monodelphis domestica)
Mammalia TRUB2 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia TRUB2 36
  • 68 (a)
(Rattus norvegicus)
Mammalia Trub2 35
  • 79.18 (n)
  • 79.81 (a)
(Gallus gallus)
Aves TRUB2 35
  • 62.06 (n)
  • 60.82 (a)
TRUB2 36
  • 57 (a)
(Anolis carolinensis)
Reptilia TRUB2 36
  • 60 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13716 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15106 35
trub2 35
  • 63.64 (n)
  • 62.34 (a)
(Danio rerio)
Actinopterygii trub2 35
  • 58.33 (n)
  • 56.88 (a)
trub2 36
  • 45 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002077 35
  • 46.34 (n)
  • 35.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7849 35
  • 47.13 (n)
  • 34.07 (a)
CG7849 36
  • 28 (a)
(Caenorhabditis elegans)
Secernentea Y43B11AR.3 36
  • 21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUS4 36
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
Species with no ortholog for TRUB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRUB2 Gene

Gene Tree for TRUB2 (if available)
Gene Tree for TRUB2 (if available)

Paralogs for TRUB2 Gene

Paralogs for TRUB2 Gene

genes like me logo Genes that share paralogs with TRUB2: view

Variants for TRUB2 Gene

Sequence variations from dbSNP and Humsavar for TRUB2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs2072394 - 128,317,191(-) TTGGC(A/C/G)TGGGA missense, reference
rs2231632 -- 128,317,145(-) TAGGT(A/G)ATGTG intron-variant
rs2231633 -- 128,317,076(-) CAGCC(C/G)ACTTC intron-variant
rs2231634 -- 128,317,007(-) ATCAG(A/C)TGGGG intron-variant
rs2231635 -- 128,311,597(-) GACCA(C/T)GTGAC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TRUB2 Gene

Variant ID Type Subtype PubMed ID
dgv8294n71 CNV Loss 21882294
nsv831728 CNV Loss 17160897

Relevant External Links for TRUB2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRUB2 Gene

Disorders for TRUB2 Gene

(1) University of Copenhagen DISEASES for TRUB2 Gene

genes like me logo Genes that share disorders with TRUB2: view

No data available for UniProtKB/Swiss-Prot for TRUB2 Gene

Publications for TRUB2 Gene

  1. The human TruB family of pseudouridine synthase genes, including the Dyskeratosis Congenita 1 gene and the novel member TRUB1. (PMID: 12736709) Zucchini C. … Valvassori L. (Int. J. Mol. Med. 2003) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PMID: 20186120) Richter R. … Chrzanowska-Lightowlers Z.M. (EMBO J. 2010) 3

Products for TRUB2 Gene

Sources for TRUB2 Gene

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