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Aliases for TRUB2 Gene

Aliases for TRUB2 Gene

  • TruB Pseudouridine Synthase Family Member 2 2 3
  • TruB Pseudouridine (Psi) Synthase Family Member 2 2 3 5
  • TruB Pseudouridine (Psi) Synthase Homolog 2 (E. Coli) 2
  • TruB Pseudouridine (Psi) Synthase Homolog 2 3
  • EC 5.4.99.- 4
  • CLONE24922 3

External Ids for TRUB2 Gene

Previous GeneCards Identifiers for TRUB2 Gene

  • GC09U990211
  • GC09M126447
  • GC09M128150
  • GC09M130111
  • GC09M131071
  • GC09M100684

Summaries for TRUB2 Gene

Entrez Gene Summary for TRUB2 Gene

  • Pseudouridine is an abundant component of rRNAs and tRNAs and is enzymatically generated by isomerization of uridine by pseudouridine synthase (Zucchini et al., 2003 [PubMed 12736709]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TRUB2 Gene

TRUB2 (TruB Pseudouridine Synthase Family Member 2) is a Protein Coding gene. Diseases associated with TRUB2 include Dyskeratosis Congenita. GO annotations related to this gene include poly(A) RNA binding and pseudouridine synthase activity. An important paralog of this gene is TRUB1.

UniProtKB/Swiss-Prot for TRUB2 Gene

  • May be responsible for synthesis of pseudouridine from uracil in transfer RNAs.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRUB2 Gene

Genomics for TRUB2 Gene

Regulatory Elements for TRUB2 Gene

Enhancers for TRUB2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRUB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRUB2 Gene

Chromosome:
9
Start:
128,305,161 bp from pter
End:
128,322,742 bp from pter
Size:
17,582 bases
Orientation:
Minus strand

Genomic View for TRUB2 Gene

Genes around TRUB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRUB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRUB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRUB2 Gene

Proteins for TRUB2 Gene

  • Protein details for TRUB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95900-TRUB2_HUMAN
    Recommended name:
    Probable tRNA pseudouridine synthase 2
    Protein Accession:
    O95900
    Secondary Accessions:
    • B7Z7G5

    Protein attributes for TRUB2 Gene

    Size:
    331 amino acids
    Molecular mass:
    36694 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRUB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRUB2 Gene

Proteomics data for TRUB2 Gene at MOPED

Post-translational modifications for TRUB2 Gene

  • Ubiquitination at Lys 36
  • Modification sites at PhosphoSitePlus

Other Protein References for TRUB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for TRUB2

No data available for DME Specific Peptides for TRUB2 Gene

Domains & Families for TRUB2 Gene

Protein Domains for TRUB2 Gene

Graphical View of Domain Structure for InterPro Entry

O95900

UniProtKB/Swiss-Prot:

TRUB2_HUMAN :
  • Belongs to the pseudouridine synthase TruB family.
Family:
  • Belongs to the pseudouridine synthase TruB family.
genes like me logo Genes that share domains with TRUB2: view

No data available for Gene Families for TRUB2 Gene

Function for TRUB2 Gene

Molecular function for TRUB2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
tRNA uridine = tRNA pseudouridine.
UniProtKB/Swiss-Prot Function:
May be responsible for synthesis of pseudouridine from uracil in transfer RNAs.

Enzyme Numbers (IUBMB) for TRUB2 Gene

Gene Ontology (GO) - Molecular Function for TRUB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with TRUB2: view
genes like me logo Genes that share phenotypes with TRUB2: view

Animal Models for TRUB2 Gene

MGI Knock Outs for TRUB2:

Animal Model Products

miRNA for TRUB2 Gene

miRTarBase miRNAs that target TRUB2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRUB2 Gene

Localization for TRUB2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRUB2 Gene COMPARTMENTS Subcellular localization image for TRUB2 gene
Compartment Confidence
cytosol 3
mitochondrion 3
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRUB2 Gene

Pathways & Interactions for TRUB2 Gene

SuperPathways for TRUB2 Gene

No Data Available

Interacting Proteins for TRUB2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000361982%0d%0a9606.ENSP00000344401%0d%0a9606.ENSP00000301585%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: O95900-TRUB2_HUMAN ENSP00000361982 for TRUB2 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for TRUB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IEA --
GO:0009451 RNA modification IEA --
genes like me logo Genes that share ontologies with TRUB2: view

No data available for Pathways by source and SIGNOR curated interactions for TRUB2 Gene

Drugs & Compounds for TRUB2 Gene

(1) Additional Compounds for TRUB2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pseudouridine
  • 5-(b-D-Ribofuranosyl)uracil
  • 5-(b-delta-Ribofuranosyl)uracil
  • 5-b-D-Ribofuranosyl-Uracil
  • 5-beta-delta-Ribofuranosyl-Uracil
  • 5-Ribosyluracil
1445-07-4
genes like me logo Genes that share compounds with TRUB2: view

Transcripts for TRUB2 Gene

mRNA/cDNA for TRUB2 Gene

Unigene Clusters for TRUB2 Gene

TruB pseudouridine (psi) synthase homolog 2 (E. coli):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRUB2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: - -
SP2: - - -
SP3:
SP4:

Relevant External Links for TRUB2 Gene

GeneLoc Exon Structure for
TRUB2
ECgene alternative splicing isoforms for
TRUB2

Expression for TRUB2 Gene

mRNA expression in normal human tissues for TRUB2 Gene

Protein differential expression in normal tissues from HIPED for TRUB2 Gene

This gene is overexpressed in Heart (58.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRUB2 Gene



SOURCE GeneReport for Unigene cluster for TRUB2 Gene Hs.632685

genes like me logo Genes that share expression patterns with TRUB2: view

Protein tissue co-expression partners for TRUB2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRUB2 Gene

Orthologs for TRUB2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRUB2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRUB2 35
  • 82.72 (n)
  • 85.98 (a)
TRUB2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRUB2 35
  • 84.14 (n)
  • 84.5 (a)
TRUB2 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trub2 35
  • 81.37 (n)
  • 81.57 (a)
Trub2 16
Trub2 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRUB2 35
  • 99.09 (n)
  • 98.49 (a)
TRUB2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trub2 35
  • 79.18 (n)
  • 79.81 (a)
oppossum
(Monodelphis domestica)
Mammalia TRUB2 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRUB2 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRUB2 35
  • 62.06 (n)
  • 60.82 (a)
TRUB2 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRUB2 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15106 35
trub2 35
  • 63.64 (n)
  • 62.34 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13716 35
zebrafish
(Danio rerio)
Actinopterygii trub2 35
  • 58.33 (n)
  • 56.88 (a)
trub2 36
  • 45 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002077 35
  • 46.34 (n)
  • 35.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7849 35
  • 47.13 (n)
  • 34.07 (a)
CG7849 36
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y43B11AR.3 36
  • 21 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUS4 36
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToOne
Species with no ortholog for TRUB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRUB2 Gene

ENSEMBL:
Gene Tree for TRUB2 (if available)
TreeFam:
Gene Tree for TRUB2 (if available)

Paralogs for TRUB2 Gene

Paralogs for TRUB2 Gene

genes like me logo Genes that share paralogs with TRUB2: view

Variants for TRUB2 Gene

Sequence variations from dbSNP and Humsavar for TRUB2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs2072394 - 128,317,191(-) TTGGC(A/C/G)TGGGA reference, missense
VAR_051608 -
rs2231637 - 128,310,931(-) GATAA(C/G)TGGCA reference, missense
rs7861019 -- 128,316,063(+) cccag(A/C)acttt intron-variant
rs7861149 -- 128,316,075(+) ggagg(C/T)cgagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRUB2 Gene

Variant ID Type Subtype PubMed ID
dgv8294n71 CNV Loss 21882294
nsv831728 CNV Loss 17160897

Variation tolerance for TRUB2 Gene

Residual Variation Intolerance Score: 85.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.75; 46.94% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TRUB2 Gene

Disorders for TRUB2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRUB2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
dyskeratosis congenita
  • revesz syndrome
- elite association - COSMIC cancer census association via MalaCards
Search TRUB2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TRUB2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRUB2
genes like me logo Genes that share disorders with TRUB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRUB2 Gene

Publications for TRUB2 Gene

  1. The human TruB family of pseudouridine synthase genes, including the Dyskeratosis Congenita 1 gene and the novel member TRUB1. (PMID: 12736709) Zucchini C. … Valvassori L. (Int. J. Mol. Med. 2003) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for TRUB2 Gene

Sources for TRUB2 Gene

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