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Aliases for TRUB1 Gene

Aliases for TRUB1 Gene

  • TruB Pseudouridine (Psi) Synthase Family Member 1 2 3
  • PUS4 3 4
  • TruB Pseudouridine (Psi) Synthase Homolog 1 (E. Coli) 2
  • TruB Pseudouridine (Psi) Synthase Homolog 1 3
  • EC 5.4.99.- 4
  • EC 5.4.99 63

External Ids for TRUB1 Gene

Previous GeneCards Identifiers for TRUB1 Gene

  • GC10P115616
  • GC10P115941
  • GC10P116829
  • GC10P116362
  • GC10P116687
  • GC10P110325

Summaries for TRUB1 Gene

Entrez Gene Summary for TRUB1 Gene

  • Pseudouridine is an abundant component of rRNAs and tRNAs and is enzymatically generated by isomerization of uridine by pseudouridine synthase (Zucchini et al., 2003 [PubMed 12736709]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TRUB1 Gene

TRUB1 (TruB Pseudouridine (Psi) Synthase Family Member 1) is a Protein Coding gene. Diseases associated with TRUB1 include dyskeratosis congenita. GO annotations related to this gene include RNA binding and pseudouridine synthase activity. An important paralog of this gene is TRUB2.

UniProtKB/Swiss-Prot for TRUB1 Gene

  • May be responsible for synthesis of pseudouridine from uracil in transfer RNAs.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRUB1 Gene

Genomics for TRUB1 Gene

Regulatory Elements for TRUB1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRUB1 Gene

114,938,193 bp from pter
114,977,680 bp from pter
39,488 bases
Plus strand

Genomic View for TRUB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRUB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRUB1 Gene

Proteins for TRUB1 Gene

  • Protein details for TRUB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable tRNA pseudouridine synthase 1
    Protein Accession:
    Secondary Accessions:
    • B2R716
    • Q53ES2

    Protein attributes for TRUB1 Gene

    349 amino acids
    Molecular mass:
    37253 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRUB1 Gene

Proteomics data for TRUB1 Gene at MOPED

Selected DME Specific Peptides for TRUB1 Gene

Post-translational modifications for TRUB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRUB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for TRUB1 Gene

Suggested Antigen Peptide Sequences for TRUB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the pseudouridine synthase TruB family.
  • Belongs to the pseudouridine synthase TruB family.
genes like me logo Genes that share domains with TRUB1: view

No data available for Gene Families for TRUB1 Gene

Function for TRUB1 Gene

Molecular function for TRUB1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
tRNA uridine = tRNA pseudouridine
UniProtKB/Swiss-Prot Function:
May be responsible for synthesis of pseudouridine from uracil in transfer RNAs.

Enzyme Numbers (IUBMB) for TRUB1 Gene

Gene Ontology (GO) - Molecular Function for TRUB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0009982 pseudouridine synthase activity IBA --
genes like me logo Genes that share ontologies with TRUB1: view

Phenotypes for TRUB1 Gene

genes like me logo Genes that share phenotypes with TRUB1: view

Animal Model Products

CRISPR Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for TRUB1 Gene

Localization for TRUB1 Gene

Subcellular locations from

Jensen Localization Image for TRUB1 Gene COMPARTMENTS Subcellular localization image for TRUB1 gene
Compartment Confidence
cytoskeleton 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRUB1 Gene

Pathways & Interactions for TRUB1 Gene

SuperPathways for TRUB1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRUB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001522 pseudouridine synthesis --
GO:0006396 RNA processing --
GO:0006400 tRNA modification IBA --
GO:0009451 RNA modification --
GO:1990481 mRNA pseudouridine synthesis IBA --
genes like me logo Genes that share ontologies with TRUB1: view

No data available for Pathways by source and SIGNOR curated interactions for TRUB1 Gene

Drugs & Compounds for TRUB1 Gene

(1) Additional Compounds for TRUB1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5-(b-D-Ribofuranosyl)uracil
  • 5-(b-delta-Ribofuranosyl)uracil
  • 5-b-D-Ribofuranosyl-Uracil
  • 5-beta-delta-Ribofuranosyl-Uracil
  • 5-Ribosyluracil
genes like me logo Genes that share compounds with TRUB1: view

Transcripts for TRUB1 Gene

mRNA/cDNA for TRUB1 Gene

Unigene Clusters for TRUB1 Gene

TruB pseudouridine (psi) synthase homolog 1 (E. coli):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRUB1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8
SP1: -
SP2: - -
SP3: - -

Relevant External Links for TRUB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRUB1 Gene

mRNA expression in normal human tissues for TRUB1 Gene

Protein differential expression in normal tissues from HIPED for TRUB1 Gene

This gene is overexpressed in Retina (27.0) and Cerebrospinal fluid (22.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRUB1 Gene

SOURCE GeneReport for Unigene cluster for TRUB1 Gene Hs.21187

mRNA Expression by UniProt/SwissProt for TRUB1 Gene

Tissue specificity: Highly expressed in heart, skeletal muscle and liver. Expressed at lower levels in lung, small intestine, kidney and spleen.
genes like me logo Genes that share expression patterns with TRUB1: view

Protein tissue co-expression partners for TRUB1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TRUB1 Gene

Orthologs for TRUB1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRUB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRUB1 35
  • 91.01 (n)
  • 92.67 (a)
TRUB1 36
  • 90 (a)
(Canis familiaris)
Mammalia TRUB1 35
  • 91.76 (n)
  • 92.82 (a)
TRUB1 36
  • 92 (a)
(Mus musculus)
Mammalia Trub1 35
  • 81.15 (n)
  • 83.04 (a)
Trub1 16
Trub1 36
  • 81 (a)
(Pan troglodytes)
Mammalia TRUB1 35
  • 99.33 (n)
  • 99.14 (a)
TRUB1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Trub1 35
  • 81.91 (n)
  • 84.07 (a)
(Monodelphis domestica)
Mammalia TRUB1 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia TRUB1 36
  • 74 (a)
(Gallus gallus)
Aves TRUB1 35
  • 76.54 (n)
  • 75.56 (a)
TRUB1 36
  • 70 (a)
(Anolis carolinensis)
Reptilia TRUB1 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8216 35
trub1 35
  • 63.78 (n)
  • 66.92 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15432 35
(Danio rerio)
Actinopterygii trub1 35
  • 64.25 (n)
  • 67.18 (a)
trub1 36
  • 61 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1341 35
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUS4 36
  • 21 (a)
PUS4 38
Species with no ortholog for TRUB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRUB1 Gene

Gene Tree for TRUB1 (if available)
Gene Tree for TRUB1 (if available)

Paralogs for TRUB1 Gene

Paralogs for TRUB1 Gene

genes like me logo Genes that share paralogs with TRUB1: view

Variants for TRUB1 Gene

Sequence variations from dbSNP and Humsavar for TRUB1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs881191 -- 114,947,202(+) tctac(A/G)gaggc intron-variant
rs881192 -- 114,947,026(+) aatca(C/T)aatat intron-variant
rs881193 -- 114,948,125(-) GTTCT(A/G)TGCTC intron-variant
rs1045657 -- 114,977,226(+) TTAGA(A/T)TTTAA utr-variant-3-prime
rs1131811 -- 114,942,736(-) AGAAC(A/T)CCTCG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TRUB1 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
nsv831996 CNV Gain 17160897
nsv831997 CNV Gain 17160897
esv2666688 CNV Deletion 23128226

Variation tolerance for TRUB1 Gene

Residual Variation Intolerance Score: 47.41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.47; 91.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRUB1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRUB1 Gene

Disorders for TRUB1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRUB1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
dyskeratosis congenita
  • revesz syndrome
- elite association
Search TRUB1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TRUB1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TRUB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRUB1 Gene

Publications for TRUB1 Gene

  1. The human TruB family of pseudouridine synthase genes, including the Dyskeratosis Congenita 1 gene and the novel member TRUB1. (PMID: 12736709) Zucchini C. … Valvassori L. (Int. J. Mol. Med. 2003) 2 23 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  3. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. (PMID: 23940030) Teixeira F.R. … Gomes M.D. (J. Biol. Chem. 2013) 67
  4. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PMID: 22223895) Bienvenut W.V. … Giglione C. (Mol. Cell Proteomics 2012) 67
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 67

Products for TRUB1 Gene

Sources for TRUB1 Gene

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