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TRUB1 Gene

protein-coding   GIFtS: 55
GCID: GC10P116687

TruB Pseudouridine (Psi) Synthase Family Member 1

(Previous name: TruB pseudouridine (psi) synthase homolog 1 (E. coli))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TruB Pseudouridine (Psi) Synthase Family Member 11 2     TruB Pseudouridine (Psi) Synthase Homolog 12
PUS42 3 5     EC 5.4.99.-3
TruB Pseudouridine (Psi) Synthase Homolog 1 (E. Coli)1     EC 5.4.998
Probable TRNA Pseudouridine Synthase 12     

External Ids:    HGNC: 160601   Entrez Gene: 1429402   Ensembl: ENSG000001658327   OMIM: 6107265   UniProtKB: Q8WWH53   

Export aliases for TRUB1 gene to outside databases

Previous GC identifers: GC10P115616 GC10P115941 GC10P116829 GC10P116362 GC10P110325


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRUB1 Gene:
Pseudouridine is an abundant component of rRNAs and tRNAs and is enzymatically generated by isomerization of
uridine by pseudouridine synthase (Zucchini et al., 2003 (PubMed 12736709)).(supplied by OMIM, Mar 2008)

GeneCards Summary for TRUB1 Gene:
TRUB1 (TruB pseudouridine (psi) synthase family member 1) is a protein-coding gene. GO annotations related to this gene include pseudouridine synthase activity and RNA binding. An important paralog of this gene is TRUB2.

UniProtKB/Swiss-Prot: TRUB1_HUMAN, Q8WWH5
Function: May be responsible for synthesis of pseudouridine from uracil in transfer RNAs (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRUB1 gene promoter:
         COUP-TF1   RP58   COUP   HNF-4alpha2   Nkx2-5   HNF-4alpha1   PPAR-gamma1   COUP-TF   STAT3   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRUB1 promoter sequence
   Search Chromatin IP Primers for TRUB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRUB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.3   Ensembl cytogenetic band:  10q25.3   HGNC cytogenetic band: 10q25.3

TRUB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRUB1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P116687:  view genomic region     (about GC identifiers)

Start:
116,697,952 bp from pter      End:
116,737,439 bp from pter
Size:
39,488 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TRUB1_HUMAN, Q8WWH5 (See protein sequence)
Recommended Name: Probable tRNA pseudouridine synthase 1  
Size: 349 amino acids; 37253 Da
Secondary accessions: B2R716 Q53ES2

Explore the universe of human proteins at neXtProt for TRUB1: NX_Q8WWH5

Explore proteomics data for TRUB1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TRUB1 (Q8WWH5) (see all 5)
     SALKKDG  KPKGPTS  GHGGTLD  LLNRLKEK 


    See TRUB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_631908.1  
    ENSEMBL proteins: 
     ENSP00000298746  

    TRUB1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals TRUB1 Protein
    Novus Biologicals TRUB1 Lysates
    Browse Sino Biological Recombinant Proteins
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRUB1

     
    Search eBioscience for Proteins for TRUB1 

     
    antibodies-online proteins for TRUB1 (4 products) 

     
    antibodies-online peptides for TRUB1

    TRUB1 Antibody Products:

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    antibodies-online antibodies for TRUB1 (16 products) 

    TRUB1 Assay Products:

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    Cloud-Clone Corp. ELISAs for TRUB1
    Cloud-Clone Corp. CLIAs for TRUB1
    Search eBioscience for ELISAs for TRUB1 
    antibodies-online kits for TRUB1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR002501 PsdUridine_synth
     IPR020103 PsdUridine_synth_cat_dom
     IPR014780 tRNA_psdUridine_synth_TruB

    Graphical View of Domain Structure for InterPro Entry Q8WWH5

    ProtoNet protein and cluster: Q8WWH5

    1 Blocks protein domain: IPB002501 Pseudouridylate synthase TruB

    UniProtKB/Swiss-Prot: TRUB1_HUMAN, Q8WWH5
    Similarity: Belongs to the pseudouridine synthase TruB family


    Find genes that share domains with TRUB1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRUB1_HUMAN, Q8WWH5
    Function: May be responsible for synthesis of pseudouridine from uracil in transfer RNAs (By similarity)
    Catalytic activity: tRNA uridine = tRNA pseudouridine

         Enzyme Numbers (IUBMB): EC 5.4.992 EC 5.4.99.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0009982pseudouridine synthase activity IEA--
         
    Find genes that share ontologies with TRUB1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TRUB1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRUB1:
    hsa-mir-17-5p (MIRT050885)

    Block miRNA regulation of human, mouse, rat TRUB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRUB1 (see all 11):
    hsa-miR-22 hsa-miR-548am hsa-miR-7-2* hsa-miR-374b hsa-miR-3617 hsa-miR-374a hsa-miR-548aa hsa-miR-641
    SwitchGear 3'UTR luciferase reporter plasmidTRUB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRUB1
    Predesigned siRNA for gene silencing in human, mouse, rat TRUB1

    Gene Editing
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    OriGene ORF clones in mouse, rat for TRUB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRUB1 (NM_139169)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRUB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRUB1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TRUB1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRUB1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytoskeleton1
    cytosol1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRUB1
    Interactions:

        Search GeneGlobe Interaction Network for TRUB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRUB1 (Q8WWH52, 3 ENSP000002987464) via UniProtKB, MINT, STRING, and/or I2D (see all 975)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEF1A1P681042, 3MINT-7945693 MINT-7947479 I2D: score=1 
    RPL19P840982, 3MINT-7945693 I2D: score=2 
    RPS13P622772, 3MINT-7947479 I2D: score=1 
    KPNB1Q149742, ENSP000002901584MINT-7945693 MINT-7947479 STRING: ENSP00000290158
    POLR1CO151602, ENSP000003614654MINT-7945693 MINT-7947479 STRING: ENSP00000361465
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001522pseudouridine synthesis IEA--
    GO:0006396RNA processing ----
    GO:0008033tRNA processing IEA--
    GO:0009451RNA modification ----

    Find genes that share ontologies with TRUB1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRUB1

    1 HMDB Compound for TRUB1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Pseudouridine5-(b-D-Ribofuranosyl)uracil (see all 12)1445-07-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRUB1 gene: 
    NM_139169.4  

    Unigene Cluster for TRUB1:

    TruB pseudouridine (psi) synthase homolog 1 (E. coli)
    Hs.21187  [show with all ESTs]
    Unigene Representative Sequence: BC030601
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000298746(uc010qsl.2 uc001lcd.3) ENST00000485065
    miRNA
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    Block miRNA regulation of human, mouse, rat TRUB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRUB1 (see all 11):
    hsa-miR-22 hsa-miR-548am hsa-miR-7-2* hsa-miR-374b hsa-miR-3617 hsa-miR-374a hsa-miR-548aa hsa-miR-641
    SwitchGear 3'UTR luciferase reporter plasmidTRUB1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TRUB1
    Predesigned siRNA for gene silencing in human, mouse, rat TRUB1
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    GenScript: all cDNA clones in your preferred vector: TRUB1 (NM_139169)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRUB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRUB1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TRUB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRUB1
      QuantiTect SYBR Green Assays in human, mouse, rat TRUB1
      QuantiFast Probe-based Assays in human, mouse, rat TRUB1

    Additional mRNA sequence: 

    AF448144.1 AK026721.1 AK125554.1 AK223567.1 AK302800.1 AK312805.1 BC030601.2 BX648443.1 
    BX648479.1 BX648709.1 

    7 DOTS entries:

    DT.100718783  DT.121265035  DT.97809515  DT.101982095  DT.215681  DT.100751204  DT.97815200 

    Selected AceView cDNA sequences (see all 111):

    AA243302 AA927829 AA410186 AI299932 N23387 AA781326 AF448144 AA243303 
    BQ961439 AI763171 AI208778 BX091117 AA984328 F04016 AA494490 Z45109 
    Z39556 AW193222 AI368111 AI304430 BX955486 BM970359 BX648479 AA806991 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TRUB1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8
    SP1:                                            -                                 
    SP2:                          -                 -                                 
    SP3:                                      -     -                                 
    SP4:                                                                              


    ECgene alternative splicing isoforms for TRUB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRUB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGCATTAAC
    TRUB1 Expression
    About this image

    TRUB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRUB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.21187

    UniProtKB/Swiss-Prot: TRUB1_HUMAN, Q8WWH5
    Tissue specificity: Highly expressed in heart, skeletal muscle and liver. Expressed at lower levels in lung, small
    intestine, kidney and spleen

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRUB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TRUB1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trub11 , 5 TruB pseudouridine (psi) synthase homolog 1 (E. coli)1, 5 81.15(n)1
    83.04(a)1
      19 (52.25 cM)5
    721331  NM_028115.31  NP_082391.11 
     574529065 
    chicken
    (Gallus gallus)
    Aves TRUB11 TruB pseudouridine (psi) synthase homolog 1 (E. coli) 76.54(n)
    75.56(a)
      423914  XM_421776.4  XP_421776.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRUB16
    TruB pseudouridine (psi) synthase family member 1
    69(a)
    1 ↔ 1
    GL343206.1(3674344-3727762)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.154322 Xenopus laevis transcribed sequence with weak similarity more 73.47(n)    BU901199.1 
    zebrafish
    (Danio rerio)
    Actinopterygii trub11 TruB pseudouridine (psi) synthase homolog 1 (E. coli) 64.25(n)
    67.18(a)
      556642  NM_001128687.1  NP_001122159.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PUS4(YNL292W)4 Pseudouridine synthase, catalyzes only the formation more   --   14(82806-84017) 855424  NP_014107.1 


    ENSEMBL Gene Tree for TRUB1 (if available)
    TreeFam Gene Tree for TRUB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRUB1 gene
    TRUB22  

    Find genes that share paralogs with TRUB1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRUB1 (see all 808)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs78949761,2
    C--116695983(+) aacccC/Tgtccc 1 -- us2k10--------
    rs1453909961,2
    C--116696028(+) ACATG-/CCT   
       GTAAT
    CCCAC
    1 -- us2k10--------
    rs1900736411,2
    --116696051(+) CAGGAG/TTCTGA 1 -- us2k10--------
    rs1388884371,2
    --116696086(+) GAGGCA/GGAGGT 1 -- us2k10--------
    rs1821235831,2
    --116696342(+) ACATGA/TATTGG 1 -- us2k10--------
    rs1848572281,2
    --116696360(+) AAAACC/GTGTGA 1 -- us2k10--------
    rs1425283891,2
    --116696443(+) AATGCC/TGATAT 1 -- us2k10--------
    rs78985311,2
    C,F,H--116696450(+) ATATAA/GTAGCA 1 -- us2k18Minor allele frequency- G:0.12NS EA WA CSA NA 660
    rs792089111,2
    --116696550(+) CTCTGC/GTCCTA 1 -- us2k10--------
    rs1892715921,2
    --116696665(+) TTGCTA/GATGTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TRUB1 (116697952 - 116737439 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TRUB1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666688CNV Deletion23128226
    nsv831997CNV Gain17160897
    nsv831996CNV Gain17160897
    nsv7211OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRUB1
    DNA2.0 Custom Variant and Variant Library Synthesis for TRUB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610726    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for TRUB1:
    Dyskeratosis congenita

    Find genes that share disorders with TRUB1           About GenesLikeMe

    Genetic Association Database (GAD): TRUB1
    Human Genome Epidemiology (HuGE) Navigator: TRUB1 (1 document)

    Export disorders for TRUB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRUB1 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with TRUB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human TruB family of pseudouridine synthase genes, including the Dyskeratosis Congenita 1 gene and the novel member TRUB1. (PubMed id 12736709)1, 2, 3, 9 Zucchini C.... Valvassori L. (Int. J. Mol. Med. 2003)
    2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. (PubMed id 23940030)1 Teixeira F.R....Gomes M.D. (J. Biol. Chem. 2013)
    7. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 142940 HGNC: 16060 AceView: TRUB1 Ensembl:ENSG00000165832 euGenes: HUgn142940
    ECgene: TRUB1 H-InvDB: TRUB1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRUB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRUB1 gene:
    Search GeneIP for patents involving TRUB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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