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Aliases for TRRAP Gene

Aliases for TRRAP Gene

  • Transformation/Transcription Domain Associated Protein 2 3 5
  • Transformation/Transcription Domain-Associated Protein 2 3
  • 350/400 KDa PCAF-Associated Factor 3 4
  • Tra1 Homolog 3 4
  • PAF350/400 3 4
  • PAF400 3 4
  • STAF40 3 4
  • TR-AP 3
  • TRA1 3

External Ids for TRRAP Gene

Previous GeneCards Identifiers for TRRAP Gene

  • GC07P097010
  • GC07P098073
  • GC07P098087
  • GC07P098120
  • GC07P098314
  • GC07P098475
  • GC07P093109

Summaries for TRRAP Gene

Entrez Gene Summary for TRRAP Gene

  • This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for TRRAP Gene

TRRAP (Transformation/Transcription Domain Associated Protein) is a Protein Coding gene. Diseases associated with TRRAP include Lung Large Cell Carcinoma and Splenic Marginal Zone Lymphoma. Among its related pathways are DNA Damage and E2F transcription factor network. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and transcription coactivator activity.

UniProtKB/Swiss-Prot for TRRAP Gene

  • Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.

Gene Wiki entry for TRRAP Gene

Additional gene information for TRRAP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRRAP Gene

Genomics for TRRAP Gene

Regulatory Elements for TRRAP Gene

Enhancers for TRRAP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H099579 1.4 FANTOM5 Ensembl ENCODE 107.2 +702.5 702468 1.2 ZNF2 ZBTB40 RAD21 ZNF366 ZNF354C ZNF202 ZNF680 ELF4 REST ZNF518A ZSCAN25 TRRAP TRIM4 LOC100131859 ZNF3 ZNF655 ENSG00000242798 STAG3L5P AP4M1 LOC101927550
GH07H098470 1.4 FANTOM5 Ensembl ENCODE 85.8 -407.2 -407222 1.2 KLF1 ATF1 ZFP64 MAX ZNF140 ZNF266 ZNF697 ZNF664 ZNF791 POLR2A TRRAP LOC101927550 LOC100131859 LOC100419643 RPS3AP26 PTCD1 SMURF1 NPTX2 BAIAP2L1 ENSG00000272950
GH07H099616 1.4 ENCODE dbSUPER 78.3 +740.3 740336 4.5 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 ZSCAN25 TRRAP ZNF3 AP4M1 TRIM4 ENSG00000242798 LOC100131859 LOC100419643 PPP1R35 PTCD1
GH07H099373 1.8 FANTOM5 ENCODE dbSUPER 57.2 +500.4 500376 9 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF143 ZNF207 ZSCAN25 TRRAP LOC101927550 ZNF655 ZNF394 TRIM4 ENSG00000242798 AP4M1 PTCD1 ZNF3
GH07H099464 1.2 ENCODE 50.1 +587.9 587872 2 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZSCAN25 ZNF3 ZNF655 TRIM4 TRRAP LOC101927550 LOC100131859 ENSG00000242798 STAG3L5P SMURF1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRRAP on UCSC Golden Path with GeneCards custom track

Promoters for TRRAP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000215586 1067 2001 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF143 ZNF207 SP5 ZNF592

Genomic Locations for TRRAP Gene

Genomic Locations for TRRAP Gene
chr7:98,877,933-99,013,243
(GRCh38/hg38)
Size:
135,311 bases
Orientation:
Plus strand
chr7:98,475,556-98,610,866
(GRCh37/hg19)

Genomic View for TRRAP Gene

Genes around TRRAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRRAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRRAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRRAP Gene

Proteins for TRRAP Gene

  • Protein details for TRRAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4A5-TRRAP_HUMAN
    Recommended name:
    Transformation/transcription domain-associated protein
    Protein Accession:
    Q9Y4A5
    Secondary Accessions:
    • A4D265
    • O75218
    • Q9Y631
    • Q9Y6H4

    Protein attributes for TRRAP Gene

    Size:
    3859 amino acids
    Molecular mass:
    437600 Da
    Quaternary structure:
    • Interacts with MYC, E2F1 and E2F4 transcription factors. Interacts directly with p53/TP53. Interacts with GCN5L2. Component of various HAT complexes. Component of the PCAF complex, at least composed of TADA2L/ADA2, SUPT3H, TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, GCN5L2/GCN5, TAF10 and TRRAP. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. Component of the STAGA complex, at least composed of SUPT3H, GCN5L2, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22. Component of the BAF53 complex, at least composed of BAF53A, RUVBL1, SMARCA4/BRG1, and TRRAP, which preferentially acetylates histone H4 (and H2A) within nucleosomes. Interacts with NPAT. Interaction with TELO2 AND TTI1. Component of a SWR1-like complex.
    SequenceCaution:
    • Sequence=AAC62433.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TRRAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRRAP Gene

Post-translational modifications for TRRAP Gene

  • Ubiquitination at Lys2638, posLast=30503050, posLast=35083508, posLast=35983598, and Lys3834
  • Modification sites at PhosphoSitePlus

Other Protein References for TRRAP Gene

No data available for DME Specific Peptides for TRRAP Gene

Domains & Families for TRRAP Gene

Gene Families for TRRAP Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for TRRAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y4A5

UniProtKB/Swiss-Prot:

TRRAP_HUMAN :
  • The PI3K/PI4K domain is required for the recruitment of HAT complexes, and the MYC-dependent transactivation. Although it is strongly related to the PI3/PI4-kinase family, it lacks the typical motifs that constitute the catalytic site of PI3/PI4-kinase proteins, and lacks such activity.
  • Belongs to the PI3/PI4-kinase family. TRA1 subfamily.
Domain:
  • The PI3K/PI4K domain is required for the recruitment of HAT complexes, and the MYC-dependent transactivation. Although it is strongly related to the PI3/PI4-kinase family, it lacks the typical motifs that constitute the catalytic site of PI3/PI4-kinase proteins, and lacks such activity.
Family:
  • Belongs to the PI3/PI4-kinase family. TRA1 subfamily.
genes like me logo Genes that share domains with TRRAP: view

Function for TRRAP Gene

Molecular function for TRRAP Gene

GENATLAS Biochemistry:
transformation/transcription domain associated protein,434kDa,essential cofactor for the c-Myc and E2F oncoproteins
UniProtKB/Swiss-Prot Function:
Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.

Phenotypes From GWAS Catalog for TRRAP Gene

Gene Ontology (GO) - Molecular Function for TRRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription cofactor activity IDA 11418595
GO:0005515 protein binding IPI 9708738
GO:0016301 kinase activity IEA,IBA --
GO:0016740 transferase activity IEA --
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity TAS --
genes like me logo Genes that share ontologies with TRRAP: view
genes like me logo Genes that share phenotypes with TRRAP: view

Animal Models for TRRAP Gene

MGI Knock Outs for TRRAP:

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRRAP Gene

Localization for TRRAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRRAP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRRAP gene
Compartment Confidence
nucleus 5
golgi apparatus 5
plasma membrane 3
peroxisome 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000125 PCAF complex NAS 9885574
GO:0000812 Swr1 complex IDA 24463511
GO:0005634 nucleus IEA,IDA 9708738
GO:0005654 nucleoplasm TAS,IDA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with TRRAP: view

Pathways & Interactions for TRRAP Gene

genes like me logo Genes that share pathways with TRRAP: view

SIGNOR curated interactions for TRRAP Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TRRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016310 phosphorylation IEA --
GO:0016569 covalent chromatin modification IEA --
genes like me logo Genes that share ontologies with TRRAP: view

Drugs & Compounds for TRRAP Gene

(1) Additional Compounds for TRRAP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TRRAP: view

Transcripts for TRRAP Gene

Unigene Clusters for TRRAP Gene

Transformation/transcription domain-associated protein:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRRAP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c ^ 22 ^
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ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30a · 30b · 30c ^ 31 ^ 32a · 32b · 32c ^ 33a · 33b · 33c ^ 34a · 34b ^ 35a · 35b ^ 36a · 36b ^ 37a · 37b ^
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ExUns: 38a · 38b ^ 39a · 39b · 39c ^ 40 ^ 41a · 41b ^ 42a · 42b ^ 43 ^ 44a · 44b ^ 45 ^ 46 ^ 47a · 47b · 47c ^ 48 ^ 49 ^ 50 ^ 51 ^ 52 ^ 53 ^ 54 ^ 55 ^
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ExUns: 56 ^ 57 ^ 58 ^ 59 ^
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Relevant External Links for TRRAP Gene

GeneLoc Exon Structure for
TRRAP
ECgene alternative splicing isoforms for
TRRAP

Expression for TRRAP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRRAP Gene

Protein differential expression in normal tissues from HIPED for TRRAP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.5), Placenta (11.5), and Bone marrow stromal cell (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRRAP Gene



Protein tissue co-expression partners for TRRAP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRRAP Gene:

TRRAP

SOURCE GeneReport for Unigene cluster for TRRAP Gene:

Hs.203952

Evidence on tissue expression from TISSUES for TRRAP Gene

  • Heart(4.2)
  • Liver(4.2)
  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with TRRAP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRRAP Gene

Orthologs for TRRAP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRRAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRRAP 33 34
  • 99.6 (n)
oppossum
(Monodelphis domestica)
Mammalia TRRAP 34
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRRAP 34
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRRAP 33 34
  • 90.02 (n)
cow
(Bos Taurus)
Mammalia TRRAP 33 34
  • 88.79 (n)
mouse
(Mus musculus)
Mammalia Trrap 33 16 34
  • 87.81 (n)
rat
(Rattus norvegicus)
Mammalia Trrap 33
  • 87.72 (n)
chicken
(Gallus gallus)
Aves TRRAP 33 34
  • 81.43 (n)
lizard
(Anolis carolinensis)
Reptilia TRRAP 34
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trrap 33
  • 79.77 (n)
Str.6856 33
zebrafish
(Danio rerio)
Actinopterygii trrap 33 34
  • 79.17 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005533 33
  • 59.73 (n)
fruit fly
(Drosophila melanogaster)
Insecta Nipped-A 33 34
  • 54.71 (n)
Tra1 35
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea trr-1 33 34
  • 42.69 (n)
C47D12.1 35
  • 23 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER393C 33
  • 43.91 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRA1 33 34 36
  • 43.3 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F22066g 33
  • 42.65 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G17930 33
  • 44.91 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 77 (a)
OneToMany
CSA.2888 34
  • 73 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU01379 33
  • 45.84 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tra1 33
  • 41.84 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13901 33
Species where no ortholog for TRRAP was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRRAP Gene

ENSEMBL:
Gene Tree for TRRAP (if available)
TreeFam:
Gene Tree for TRRAP (if available)

Paralogs for TRRAP Gene

Pseudogenes.org Pseudogenes for TRRAP Gene

genes like me logo Genes that share paralogs with TRRAP: view

No data available for Paralogs for TRRAP Gene

Variants for TRRAP Gene

Sequence variations from dbSNP and Humsavar for TRRAP Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs373632999 A colorectal adenocarcinoma sample 98,949,733(+) GCGAC(A/G)TGTGT reference, missense
rs528967912 A colorectal adenocarcinoma sample 98,964,724(+) TGGTC(C/T)GGGAG reference, missense
rs753661271 A lung large cell carcinoma sample 98,976,613(+) CCGAC(C/T)CTGCG reference, missense
rs782203759 A gastric adenocarcinoma sample 98,950,120(+) TGGTC(A/G)TTTTC reference, missense
VAR_041658 An ovarian serous carcinoma sample

Structural Variations from Database of Genomic Variants (DGV) for TRRAP Gene

Variant ID Type Subtype PubMed ID
nsv474360 CNV novel sequence insertion 20440878
nsv1140825 CNV deletion 24896259
esv3614265 CNV loss 21293372

Variation tolerance for TRRAP Gene

Residual Variation Intolerance Score: 0.0181% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.22; 52.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRRAP Gene

Human Gene Mutation Database (HGMD)
TRRAP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRRAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRRAP Gene

Disorders for TRRAP Gene

MalaCards: The human disease database

(3) MalaCards diseases for TRRAP Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
lung large cell carcinoma
  • large cell carcinoma of lung
splenic marginal zone lymphoma
  • smzl
spinocerebellar ataxia 7
  • spinocerebellar ataxia type 7
- elite association - COSMIC cancer census association via MalaCards
Search TRRAP in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TRRAP_HUMAN
  • Note=TRRAP mutation Phe-722 has been frequently found in cutaneous malignant melanoma, suggesting that TRRAP may play a role in the pathogenesis of melanoma. {ECO:0000269 PubMed:21499247}.

Relevant External Links for TRRAP

Genetic Association Database (GAD)
TRRAP
Human Genome Epidemiology (HuGE) Navigator
TRRAP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRRAP
genes like me logo Genes that share disorders with TRRAP: view

No data available for Genatlas for TRRAP Gene

Publications for TRRAP Gene

  1. The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. (PMID: 9708738) McMahon SB … Cole MD (Cell 1998) 2 3 4 22 60
  2. Transcriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transition. (PMID: 17967892) DeRan M … Zhao J (Molecular and cellular biology 2008) 3 4 22 60
  3. c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation. (PMID: 12660246) Liu X … Martinez E (The Journal of biological chemistry 2003) 3 4 22 60
  4. The adenovirus E1A oncoprotein recruits the cellular TRRAP/GCN5 histone acetyltransferase complex. (PMID: 12743606) Lang SE … Hearing P (Oncogene 2003) 3 4 22 60
  5. BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation. (PMID: 11839798) Park J … Cole MD (Molecular and cellular biology 2002) 3 4 22 60

Products for TRRAP Gene

Sources for TRRAP Gene

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