TRRAP Gene
protein-coding GIFtS : 60 GCID: GC07 P098475
transformation/transcription domain-associated protein
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Aliasesfor TRRAP gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Transformation/Transcription Domain-Associated Protein 1 2 Tra1 Homolog2 3 PAF4001 2 3 350/400 KDa PCAF-Associated Factor2 3 TR-AP1 2 PAF350/4002 3 Tra11 2 STAF402 3
Export aliases for TRRAP gene to outside databases Previous GC identifers: GC07P097010 GC07P098073 GC07P098087 GC07P098120 GC07P098314 GC07P093109
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Summariesfor TRRAP gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for TRRAP : This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Sep 2011) UniProtKB/Swiss-Prot: TRRAP_HUMAN, Q9Y4A5 Function : Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferaseactivity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression Gene Wiki entry for TRRAP (Transformation/transcription domain-associated protein)
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Genomic Viewsfor TRRAP gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TRRAP gene promoter:HOXA9 HOXA9B p53 RREB-1 Pax-6 Meis-1b PPAR-gamma1 PPAR-gamma2 Meis-1 Other transcription factors Search SABiosciences Chromatin IP Primers for TRRAP Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 7q21.2-q22.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q21.2-q22.1 TRRAP Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 7 GeneLoc Exon Structure
GeneLoc location for GC07P098475: view genomic region
(about GC identifiers )
Start: 98,475,556 bp from pter End:
98,610,866 bp from pter
Size: 135,311 bases Orientation:
plus strand
1 alternative location : Chr 7+,CRA_TCAG 97,832,168-97,966,885
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Proteinsfor TRRAP gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TRRAP_HUMAN, Q9Y4A5 See
protein sequence )Recommended Name: Size : 3859 amino acids; 437600 DaSubunit : Interacts with MYC, E2F1 and E2F4 transcription factors. Interacts directly with p53/TP53. Interacts withGCN5L2. Component of various HAT complexes. Component of the PCAF complex, at least composed of TADA2L/ADA2, SUPT3H, TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, GCN5L2/GCN5, TAF10 and TRRAP. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. Component of the STAGA complex, at least composed of SUPT3H, GCN5L2, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22. Component of the BAF53 complex, at least composed of BAF53A, RUVBL1, SMARCA4/BRG1, and TRRAP, which preferentially acetylates histone H4 (and H2A) within nucleosomes. Interacts with NPAT. Interaction with TELO2 AND TTI1
Subcellular location : NucleusSequence caution : Sequence=AAC62433.1; Type=Erroneous gene model prediction;Secondary accessions : A4D265 O75218 Q9Y631 Q9Y6H4Alternative splicing : 2 isoforms : Q9Y4A5-1 Q9Y4A5-2 Explore the universe of human proteins at neXtProt for TRRAP: NX_Q9Y4A5 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9Y4A5 TRRAP Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (2 alternative transcripts): NP_001231509.1 NP_003487.1 ENSEMBL proteins: ENSP00000401107 ENSP00000352925 ENSP00000347733 ENSP00000403708 ENSP00000394645 Human Recombinant Protein Products: Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7 ): About this table
About GeneDecksing TRRAP Antibody Products: Assay Products for TRRAP:
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Protein
Domains /for TRRAP gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5/8 InterPro domains/families (see all 8 ):
Graphical View of Domain Structure for InterPro Entry Q9Y4A5 ProtoNet protein and cluster: Q9Y4A5
2 Blocks protein families : IPB000403 IPB003151 UniProtKB/Swiss-Prot: TRRAP_HUMAN, Q9Y4A5 Domain : The PI3K/PI4K domain is required for the recruitment of HAT complexes, and the MYC-dependent transactivation.Although it is strongly related to the PI3/PI4-kinase family, it lacks the typical motifs that constitute the catalytic site of PI3/PI4-kinase proteins, and lacks such activity Similarity : Belongs to the PI3/PI4-kinase family. TRA1 subfamilySimilarity : Contains 1 FAT domainSimilarity : Contains 1 FATC domainSimilarity : Contains 1 PI3K/PI4K domain
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Functionfor TRRAP gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: TRRAP_HUMAN, Q9Y4A5 Function : Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferaseactivity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression
Genatlas biochemistry entry for TRRAP transformation/transcription domain associated protein,434kDa,essential cofactor for the c-Myc and E2F oncoproteins Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 2 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TRRAP (NM_003496 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRRAP Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRRAP
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRRAP
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003712 transcription cofactor activity
IDA 11418595 GO:0003713 transcription coactivator activity
IEA -- GO:0005515 protein binding
IPI -- GO:0016773 phosphotransferase activity, alcohol group as acceptor
IEA --
About GeneDecksing 6 GenomeRNAi human phenotypes for TRRAP :Animal Models: Trrap tm1.1Zqw Trrap tm1Zqw 2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Trrap) :About GeneDecksing
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Pathways & Interactionsfor TRRAP gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/8 super-pathways (see all 8 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Chromatin Regulation / Acetylation 2 Cell Cycle / Checkpoint Control 3 Regulation of Wnt-mediated beta catenin signaling and target gene transcription 4 Validated targets of C-MYC transcriptional activation 5 C-MYC pathway
Pathway sources See GeneCards unified pathways Show all pathways 1 2 5 About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRRAP STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/701 Interacting proteins for TRRAP (Q9Y4A5 1 , 2 , 3 ENSP00000347733 4 via UniProtKB, MINT, STRING , and/or I2D (see all 701 )About this table Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7 ): About this table
About GeneDecksing
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Drugs & Compoundsfor TRRAP gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for TRRAP 1 Novoseek chemical compound relationship for TRRAP gene About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
polypropylene glycol
73.2
2
12743606 (1), 16880778 (1)
TRRAP
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Transcriptsfor TRRAP gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TRRAP gene (2 alternative transcripts): NM_001244580.1 NM_003496.3 Unigene Cluster for TRRAP:
Transformation/transcription domain-associated protein Hs.203952 [show with all ESTs ] Unigene Representative Sequence: NM_001244580 6 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000417523 ENST00000359863 (uc003upp.3 ) ENST00000355540 (uc011kis.2 )ENST00000446306 ENST00000456197 (uc003upr.3 ) ENST00000480695 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 2 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TRRAP (NM_003496 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRRAP Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRRAP
Additional cDNA sequence: AB209489.1 AF076974.1 AF110377.1 AL050077.1 BC032759.1 BC141939.1
7 DOTS entries : DT.95277995 DT.100851361
DT.100777288 DT.100777290 DT.75179516 DT.91854074 DT.91889772 24/213 AceView cDNA sequences (see all 213 ):
BM905882 AI247550 AL706886 AW027295 BM802455 BQ436958 AF076974 BM665438 BU727573 CD245014 BG258802 NM_003496 BM711519 BQ653146 BF432365 CF272192 BE467099 BQ049770 R18144 AF110377 AI369627 BU159147 BQ653171 BQ643828 GeneLoc Exon Structure 5/28 Alternative Splicing Database (ASD) splice patterns (SP) for TRRAP (see all 28 ) About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c ^ 22 ^ SP1 : SP2 : SP3 : SP4 : SP5 :
ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30a · 30b · 30c ^ 31 ^ 32a · 32b · 32c ^ 33a · 33b · 33c ^ 34a · 34b ^ 35a · 35b ^ 36a · 36b ^ 37a · 37b ^ SP1 : SP2 : SP3 : SP4 : SP5 :
ExUns: 38a · 38b ^ 39a · 39b · 39c ^ 40 ^ 41a · 41b ^ 42a · 42b ^ 43 ^ 44a · 44b ^ 45 ^ 46 ^ 47a · 47b · 47c ^ 48 ^ 49 ^ 50 ^ 51 ^ 52 ^ 53 ^ 54 ^ 55 ^ SP1 : SP2 : - SP3 : SP4 : SP5 :
ExUns: 56 ^ 57 ^ 58 ^ 59 ^ SP1 : SP2 : SP3 : SP4 : SP5 :
ECgene alternative splicing isoforms for TRRAP
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Expression for TRRAP gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TRRAP expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CTGGTTTTTC
About this image See TRRAP Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TRRAP SOURCE GeneReport for Unigene cluster: Hs.203952 SABiosciences Custom PCR Arrays for TRRAP Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRRAP
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Orthologsfor TRRAP gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for TRRAP gene from 10/32 species (see all 32 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
mouse Mammalia Trrap1 5
transformation/transcription domain-associated protein less 1, 5
87.95(n) 1 99.06(a) 1
5 (84.77 cM) 5 100683 1 NM_001081362.1 1 NP_001074831.1 1 144768092 5
chicken Aves TRRAP1
transformation/transcription domain-associated protein less
81.7(n) 97.28(a)
416440 XM_414752.3 XP_414752.2
lizard Reptilia TRRAP6
--
91(a)
1 ↔ 1
GL343385.1(11352-82968)
tropical clawed frog Amphibia Str.68562
Transcribed sequence with strong similarity to protein refNP_003487.1 (H.sapiens) transformation/transcription domain-associated protein [Homo sapiens] less
79.21(n)
141995373
zebrafish Actinopterygii trrap1
transformation/transcription domain-associated protein less
79.25(n) 93.02(a)
557263 XM_001919241.4 XP_001919276.3
fruit fly Insecta Tra13 1
protein kinase3 1
51(a) 3 54.49(n) 1 54.2(a) 1
41F13 35483 1 NM_001103722.2 1 NP_001097192.2 1
worm Secernentea C47D12.13 1
Yeast YHP9 like3 1
23(a) 3 42.34(n) 1 29.18(a) 1
II(11661702-11675758)3 174788 1 NM_001026861.3 1 NP_001022032.1 1
baker's yeast Saccharomycetes TRA1(YHR099W)4 1
Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation less 4 1
42.44(n) 1 30.12(a) 1
8(302761-313995) 4 856499 1, 4 NP_011967.1 1, 4
thale cress eudicotyledons AT2G179301
transformation/transcription domain-associated protein less
44.71(n) 31.75(a)
816303 NM_127347.5 NP_179383.3
rice Liliopsida ----(see all 3 )
FAT domain-containing protein, putative, expressed... Phosphatidylinositol kinase and FAT containing dom... (see all 3 )30(a) 25(a) (see all 3 )
many → 1many → 1(see all 3 )
7(26900960-26907551) 7(26885313-26891123)
ENSEMBL Gene Tree for TRRAP (if available)TreeFam Gene Tree for TRRAP (if available)
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Paralogsfor TRRAP gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for TRRAP gene About GeneDecksing 1 Pseudogenes.org Pseudogene for TRRAP PGOHUM00000238920
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Genomic Variantsfor TRRAP gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 7 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for TRRAP (98475556 - 98610866 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for TRRAP: -- Human Gene Mutation Database (HGMD) : TRRAP 1 SABiosciences Cancer Mutation PCR Assay for TRRAP : Cosmic Id AA Change 107494 p.S722F
1 SABiosciences qBiomarker Copy Number PCR Array containing TRRAP :
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor TRRAP gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
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About This Section About GeneDecksing OMIM gene information: 603015
OMIM disorders : --UniProtKB/Swiss-Prot: TRRAP_HUMAN, Q9Y4A5 Note=TRRAP mutation Phe-722 has been frequently found in cutaneous malignant melanoma, suggesting that TRRAP may play a role in the pathogenesis of melanoma (PubMed:21499247) 19 : About MalaCards dosage-sensitive sex reversal sex reversal glioblastoma williams syndrome liver cirrhosis retinal degeneration hepatocellular carcinoma retinitis lung cancer breast cancer schizophrenia thyroiditis melanoma adenocarcinoma carcinoma pancreatitis hepatitis alcoholism ischemia 2 Novoseek disease relationships for TRRAP gene About this table
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-log (P-Val)
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PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma
24
1
11781841 (1)
cancer
0
1
17694078 (1)
Human Genome Epidemiology (HuGE) Navigator: TRRAP (1 document)Export disorders for TRRAP gene to outside databases
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Publicationsfor TRRAP gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TRRAP gene, integrated from 9 sources (see all 122 ):(articles sorted by number of sources associating them with TRRAP) Utopia : connect your pdf to the dynamic
The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. (PubMed id 9708738) 1 , 2 , 3, 9(1998) The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily. (PubMed id 9885574) 1 , 2 , 3(1998) c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation. (PubMed id 12660246) 1 , 2 , 9(2003) E2F transcriptional activation requires TRRAP and GCN5 cofactors. (PubMed id 11418595) 1 , 2 , 9(2001) The ATM-related domain of TRRAP is required for histone acetyltransferase recruitment and Myc-dependent oncogenesis. (PubMed id 11445536) 1 , 2 , 9(2001) The adenovirus E1A oncoprotein recruits the cellular TRRAP/GCN5 histone acetyltransferase complex. (PubMed id 12743606) 1 , 2 , 9(2003) The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc. (PubMed id 10611234) 1 , 2 , 9(2000) Transcriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transition. (PubMed id 17967892) 1 , 2 , 9(2008) BAF53 forms distinct nuclear complexes and functions as a critical c- Myc-interacting nuclear cofactor for oncogenic transformation. (PubMed id 11839798) 1 , 2 , 9(2002) Exome sequencing identifies GRIN2A as frequently muta ted in melanoma. (PubMed id 21499247) 1 , 2 (2011)
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About This Section Patent Information for TRRAP gene: TRRAP GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TRRAP gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
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Browse OriGene Antibodies OriGene shRNA RFP for TRRAP OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TRRAP OriGene 3'-UTR Clone for TRRAP OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRRAP QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
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