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TRRAP Gene

protein-coding   GIFtS: 66
GCID: GC07P098475

Transformation/Transcription Domain-Associated Protein

  See TRRAP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transformation/Transcription Domain-Associated Protein1 2     PAF4002 3
Tra1 Homolog2 3     STAF402 3
350/400 KDa PCAF-Associated Factor2 3     TR-AP2
PAF350/4002 3     Tra12

External Ids:    HGNC: 123471   Entrez Gene: 82952   Ensembl: ENSG000001963677   OMIM: 6030155   UniProtKB: Q9Y4A53   

Export aliases for TRRAP gene to outside databases

Previous GC identifers: GC07P097010 GC07P098073 GC07P098087 GC07P098120 GC07P098314 GC07P093109


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRRAP Gene:
This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The
encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in
transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role
in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding
multiple isoforms have been observed for this gene. (provided by RefSeq, Sep 2011)

GeneCards Summary for TRRAP Gene:
TRRAP (transformation/transcription domain-associated protein) is a protein-coding gene. Diseases associated with TRRAP include glioblastoma multiforme, and dosage-sensitive sex reversal. GO annotations related to this gene include transcription coactivator activity and phosphotransferase activity, alcohol group as acceptor.

UniProtKB/Swiss-Prot: TRRAP_HUMAN, Q9Y4A5
Function: Adapter protein, which is found in various multiprotein chromatin complexes with histone
acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component
of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and
H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC.
Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription
activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes.
Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby
allowing transcription activation. Probably not required in the steps following histone acetylation in processes
of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression.
Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the
nucleosome

Gene Wiki entry for TRRAP (Transformation/transcription domain-associated protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRRAP gene promoter:
         HOXA9   HOXA9B   p53   RREB-1   Pax-6   Meis-1b   PPAR-gamma1   PPAR-gamma2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TRRAP promoter sequence
   Search Chromatin IP Primers for TRRAP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRRAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.2-q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q21.2-q22.1

TRRAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRRAP gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P098475:  view genomic region     (about GC identifiers)

Start:
98,475,556 bp from pter      End:
98,610,866 bp from pter
Size:
135,311 bases      Orientation:
plus strand

2 alternative locations:
Chr7+,CRA_TCAG 97,832,168-97,966,885      Chr7+,NW_003571041 247,672-327,275     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRRAP_HUMAN, Q9Y4A5 (See protein sequence)
Recommended Name: Transformation/transcription domain-associated protein  
Size: 3859 amino acids; 437600 Da
Subunit: Interacts with MYC, E2F1 and E2F4 transcription factors. Interacts directly with p53/TP53. Interacts with
GCN5L2. Component of various HAT complexes. Component of the PCAF complex, at least composed of TADA2L/ADA2,
SUPT3H, TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP.
Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H/SPT3, TAF2/TAFII150,
TAF4/TAFII135, TAF5/TAFII100, GCN5L2/GCN5, TAF10 and TRRAP. Component of the NuA4 histone acetyltransferase
complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1,
DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41,
VPS72/YL1 and MEAF6. Component of the STAGA complex, at least composed of SUPT3H, GCN5L2, SUPT7L, TAF5L, TAF6L,
TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. The STAGA core complex is associated with a subcomplex required for
histone deubiquitination composed of ATXN7L3, ENY2 and USP22. Component of the BAF53 complex, at least composed
of BAF53A, RUVBL1, SMARCA4/BRG1, and TRRAP, which preferentially acetylates histone H4 (and H2A) within
nucleosomes. Interacts with NPAT. Interaction with TELO2 AND TTI1. Component of a SWR1-like complex
Sequence caution: Sequence=AAC62433.1; Type=Erroneous gene model prediction;
Secondary accessions: A4D265 O75218 Q9Y631 Q9Y6H4
Alternative splicing: 2 isoforms:  Q9Y4A5-1   Q9Y4A5-2   

Explore the universe of human proteins at neXtProt for TRRAP: NX_Q9Y4A5

Explore proteomics data for TRRAP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys2059, Lys2638, Lys3050, Lys3508, Lys3598, Lys3834
  • Modification sites at PhosphoSitePlus

  • See TRRAP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001231509.1  NP_003487.1  

    ENSEMBL proteins: 
     ENSP00000401107   ENSP00000352925   ENSP00000347733   ENSP00000403708   ENSP00000394645  
    Reactome Protein details: Q9Y4A5

    TRRAP Human Recombinant Protein Products:

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    Novus Biologicals TRRAP Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRRAP

     
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    Novus Biologicals TRRAP Antibodies
    Abcam antibodies for TRRAP
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    ThermoFisher Antibodies for TRRAP
    LSBio Antibodies in human, mouse, rat for TRRAP

    TRRAP Assay Products:

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    Cloud-Clone Corp. ELISAs for TRRAP
    Cloud-Clone Corp. CLIAs for TRRAP
    Search eBioscience for ELISAs for TRRAP 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: transformation/transcription domain-associated protein
    TRRAP subfamily

    Selected InterPro protein domains (see all 8):
     IPR011990 TPR-like_helical
     IPR011989 ARM-like
     IPR011009 Kinase-like_dom
     IPR014009 PIK_FAT
     IPR000403 PI3/4_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y4A5

    ProtoNet protein and cluster: Q9Y4A5

    2 Blocks protein domains:
    IPB000403 Phosphatidylinositol 3- and 4-kinase
    IPB003151 PIK-related kinase


    UniProtKB/Swiss-Prot: TRRAP_HUMAN, Q9Y4A5
    Domain: The PI3K/PI4K domain is required for the recruitment of HAT complexes, and the MYC-dependent
    transactivation. Although it is strongly related to the PI3/PI4-kinase family, it lacks the typical motifs that
    constitute the catalytic site of PI3/PI4-kinase proteins, and lacks such activity
    Similarity: Belongs to the PI3/PI4-kinase family. TRA1 subfamily
    Similarity: Contains 1 FAT domain
    Similarity: Contains 1 FATC domain
    Similarity: Contains 1 PI3K/PI4K domain


    Find genes that share domains with TRRAP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRRAP_HUMAN, Q9Y4A5
    Function: Adapter protein, which is found in various multiprotein chromatin complexes with histone
    acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component
    of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and
    H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC.
    Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription
    activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes.
    Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby
    allowing transcription activation. Probably not required in the steps following histone acetylation in processes
    of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression.
    Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the
    nucleosome

         Genatlas biochemistry entry for TRRAP:
    transformation/transcription domain associated protein,434kDa,essential cofactor for the c-Myc and E2F
    oncoproteins

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003712transcription cofactor activity IDA11418595
    GO:0003713transcription coactivator activity IEA--
    GO:0005488binding ----
    GO:0005515protein binding IPI11415895
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    Find genes that share ontologies with TRRAP           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for TRRAP:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased cell death HMECs cel  Increased circadian rhythm amp 
     Increased colony dispersion (i  Upregulation of Wnt/beta-caten 

         2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Trrap):
     embryogenesis  mortality/aging 

    Find genes that share phenotypes with TRRAP           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TRRAP: Trraptm1.1Zqw Trraptm1Zqw

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRRAP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRRAP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRRAP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRRAP

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRRAP:
    hsa-mir-9-5p (MIRT021348), hsa-let-7e-5p (MIRT051634), hsa-mir-185-5p (MIRT045381), hsa-mir-1301-3p (MIRT036039), hsa-mir-330-3p (MIRT043836), hsa-mir-760 (MIRT036716), hsa-mir-193b-3p (MIRT041264), hsa-mir-23a-3p (MIRT050404), hsa-mir-31-5p (MIRT049886), hsa-mir-106b-5p (MIRT044338), hsa-mir-17-5p (MIRT050991), hsa-let-7a-5p (MIRT052563), hsa-mir-181b-5p (MIRT047272), hsa-mir-1229-3p (MIRT036320), hsa-mir-30a-5p (MIRT028429), hsa-let-7c-5p (MIRT051861), hsa-mir-335-5p (MIRT017022)

    Block miRNA regulation of human, mouse, rat TRRAP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRRAP (see all 17):
    hsa-miR-3163 hsa-miR-520d-5p hsa-miR-181c hsa-miR-130a* hsa-miR-181a hsa-miR-23c hsa-miR-340 hsa-miR-181d
    SwitchGear 3'UTR luciferase reporter plasmidTRRAP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRRAP
    Predesigned siRNA for gene silencing in human, mouse, rat TRRAP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRRAP

    Clone
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    OriGene clones in human, mouse for TRRAP (see all 4)
    OriGene ORF clones in mouse, rat for TRRAP
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    GenScript: all cDNA clones in your preferred vector: TRRAP (NM_003496)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRRAP
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    Addgene plasmids for TRRAP 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRRAP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRRAP_HUMAN, Q9Y4A5: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane3
    peroxisome2
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000125PCAF complex NAS9885574
    GO:0000812Swr1 complex IDA--
    GO:0005634nucleus IDA9708738
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex ----

    Find genes that share ontologies with TRRAP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TRRAP About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    HATs acetylate histones0.34
    Chromatin organization0.34
    Chromatin modifying enzymes0.34
    2Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    3Packaging Of Telomere Ends
    Histone modification0.31
    4Validated targets of C-MYC transcriptional activation
    Validated targets of C-MYC transcriptional activation
    5Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription


    Find genes that share SuperPaths with TRRAP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for TRRAP
        Chromatin Regulation / Acetylation
    Cell Cycle / Checkpoint Control

    5 BioSystems Pathways for TRRAP
        E2F transcription factor network
    Direct p53 effectors
    C-MYC pathway
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    Validated targets of C-MYC transcriptional activation

    2 Reactome Pathways for TRRAP
        HATs acetylate histones
    formation of the beta-catenin:TCF transactivating complex


    1 Kegg Pathway  (Kegg details for TRRAP):
        HTLV-I infection

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRRAP
    Interactions:

        GeneGlobe Interaction Network for TRRAP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRRAP (Q9Y4A51, 2, 3 ENSP000003477334) via UniProtKB, MINT, STRING, and/or I2D (see all 853)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4HP628053, ENSP000002893524I2D: score=2 STRING: ENSP00000289352
    HIST1H4FP628053, ENSP000003669744I2D: score=2 STRING: ENSP00000366974
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006325chromatin organization TAS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0007093mitotic cell cycle checkpoint IEA--
    GO:0016573histone acetylation NAS10966108

    Find genes that share ontologies with TRRAP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRRAP

    1 Novoseek inferred chemical compound relationship for TRRAP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polypropylene glycol 73.2 2 12743606 (1), 16880778 (1)



    Find genes that share compounds with TRRAP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRRAP gene (2 alternative transcripts): 
    NM_001244580.1  NM_003496.3  

    Unigene Cluster for TRRAP:

    Transformation/transcription domain-associated protein
    Hs.203952  [show with all ESTs]
    Unigene Representative Sequence: NM_001244580
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000417523 ENST00000359863(uc003upp.3) ENST00000355540(uc011kis.2)
    ENST00000446306 ENST00000456197(uc003upr.3) ENST00000480695
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TRRAP (see all 17):
    hsa-miR-3163 hsa-miR-520d-5p hsa-miR-181c hsa-miR-130a* hsa-miR-181a hsa-miR-23c hsa-miR-340 hsa-miR-181d
    SwitchGear 3'UTR luciferase reporter plasmidTRRAP 3' UTR sequence
    Inhib. RNA
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRRAP (NM_003496)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRRAP
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRRAP
    Addgene plasmids for TRRAP 
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat TRRAP
      QuantiFast Probe-based Assays in human, mouse, rat TRRAP

    Additional mRNA sequence: 

    AB209489.1 AF076974.1 AF110377.1 AL050077.1 BC032759.1 BC141939.1 

    7 DOTS entries:

    DT.95277995  DT.100851361  DT.100777288  DT.100777290  DT.75179516  DT.91854074  DT.91889772 

    Selected AceView cDNA sequences (see all 213):

    AI247550 BU165503 AF076974 BQ643828 AA077220 NM_003496 BM927721 BF589216 
    BM711519 CF786082 BQ049770 BG258802 AF110377 BF432365 CF272192 R18144 
    AI369627 AV709585 BU727573 BU159147 BM466855 AL706886 BU429791 BQ653146 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TRRAP (see all 28)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c ^ 22 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30a · 30b · 30c ^ 31 ^ 32a · 32b · 32c ^ 33a · 33b · 33c ^ 34a · 34b ^ 35a · 35b ^ 36a · 36b ^ 37a · 37b ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 38a · 38b ^ 39a · 39b · 39c ^ 40 ^ 41a · 41b ^ 42a · 42b ^ 43 ^ 44a · 44b ^ 45 ^ 46 ^ 47a · 47b · 47c ^ 48 ^ 49 ^ 50 ^ 51 ^ 52 ^ 53 ^ 54 ^ 55 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                      -                                                                     
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 56 ^ 57 ^ 58 ^ 59 ^
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for TRRAP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    TRRAP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGTTTTTC
    TRRAP Expression
    About this image

    TRRAP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRRAP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.203952
        Custom PCR Arrays for TRRAP
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRRAP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TRRAP gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trrap1 , 5 transformation/transcription domain-associated protein1, 5 87.81(n)1
    98.77(a)1
      5 (84.77 cM)5
    1006831  NM_001081362.11  NP_001074831.11 
     1447680925 
    chicken
    (Gallus gallus)
    Aves TRRAP1 transformation/transcription domain-associated protein 81.43(n)
    96.88(a)
      416440  XM_004945109.1  XP_004945166.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRRAP6
    transformation/transcription domain-associated pro...
    92(a)
    1 ↔ 1
    GL343385.1(11352-83831)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.68562 Transcribed sequence with strong similarity to protein more 79.21(n)    141995373 
    zebrafish
    (Danio rerio)
    Actinopterygii trrap1 transformation/transcription domain-associated protein 79.17(n)
    92.84(a)
      557263  XM_001919241.5  XP_001919276.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tra13
    Nipped-A1
    protein kinase3
    Nipped-A1
    51(a)3
    54.71(n)1
    54.65(a)1
      41F13
    354831  NM_001103722.31  NP_001097192.21 
    worm
    (Caenorhabditis elegans)
    Secernentea C47D12.13
    trr-11
    Yeast YHP9 like3
    trr-11
    23(a)3
    42.69(n)1
    29.64(a)1
      II(11661702-11675758)3
    1747881  NM_001026861.41  NP_001022032.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TRA1(YHR099W)4
    TRA11
    Subunit of SAGA and NuA4 histone acetyltransferase more4
    TRA11
    43.3(n)1
    31.31(a)1
      8(302761-313995)4
    8564991, 4  NP_011967.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G179301 AT2G17930 44.91(n)
    32.19(a)
      816303  NM_127347.5  NP_179383.3 


    ENSEMBL Gene Tree for TRRAP (if available)
    TreeFam Gene Tree for TRRAP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRRAP gene

    Find genes that share paralogs with TRRAP           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TRRAP
    PGOHUM00000238920


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for TRRAP (see all 3336)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0416614
    A gastric adenocarcinoma sample4--see VAR_0416612 R H mis40--------
    VAR_0416684
    A lung large cell carcinoma sample4--see VAR_0416682 P L mis40--------
    VAR_0416604
    A colorectal adenocarcinoma sample4--see VAR_0416602 R H mis40--------
    VAR_0416634
    A colorectal adenocarcinoma sample4--see VAR_0416632 P L mis40--------
    VAR_0416714
    A colorectal adenocarcinoma sample4--see VAR_0416712 T M mis40--------
    VAR_0416584
    An ovarian serous carcinoma sample4--see VAR_0416582 R C mis40--------
    VAR_0416664
    A colorectal adenocarcinoma sample4--see VAR_0416662 R W mis40--------
    VAR_0416644
    An ovarian mucinous carcinoma sample4--see VAR_0416642 R L mis40--------
    rs342111831,2
    C--93155215(+) GTCTC-/AAAAAA 2 -- int10--------
    rs106508661,2
    C--93163536(+) ttgga-/T/TT  
            
    ttttt
    2 -- int1 trp30--------

    HapMap Linkage Disequilibrium report for TRRAP (98475556 - 98610866 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TRRAP: --
    Human Gene Mutation Database (HGMD): TRRAP
    1 Site Specific Mutation Identification with PCR Assay for TRRAP:
    Cosmic IdAA Change
    107494p.S722F
    1 Copy Number PCR Panel containing TRRAP:
    Pancreatic Cancer
    SeqTarget long-range PCR primers for resequencing TRRAP
    DNA2.0 Custom Variant and Variant Library Synthesis for TRRAP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603015    OMIM disorders: --

    UniProtKB/Swiss-Prot: TRRAP_HUMAN, Q9Y4A5
  • Note=TRRAP mutation Phe-722 has been frequently found in cutaneous malignant melanoma, suggesting that
    TRRAP may play a role in the pathogenesis of melanoma (PubMed:21499247)

  • 2 diseases for TRRAP:    
    About MalaCards
    glioblastoma multiforme    dosage-sensitive sex reversal


    Find genes that share disorders with TRRAP           About GenesLikeMe

    2 Novoseek inferred disease relationships for TRRAP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 24 1 11781841 (1)
    cancer 0 1 17694078 (1)

    Genetic Association Database (GAD): TRRAP
    Human Genome Epidemiology (HuGE) Navigator: TRRAP (1 document)

    Export disorders for TRRAP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for TRRAP gene, integrated from 10 sources (see all 132):
    (articles sorted by number of sources associating them with TRRAP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. (PubMed id 9708738)1, 2, 3, 9 McMahon S.B.... Cole M.D. (Cell 1998)
    2. The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily. (PubMed id 9885574)1, 2, 3 Vassilev A.... Nakatani Y. (Mol. Cell 1998)
    3. c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation. (PubMed id 12660246)1, 2, 9 Liu X.... Martinez E. (J. Biol. Chem. 2003)
    4. E2F transcriptional activation requires TRRAP and GCN5 cofactors. (PubMed id 11418595)1, 2, 9 Lang S.E.... Hearing P. (J. Biol. Chem. 2001)
    5. The ATM-related domain of TRRAP is required for histone acetyltransferase recruitment and Myc-dependent oncogenesis. (PubMed id 11445536)1, 2, 9 Park J.... Cole M.D. (Genes Dev. 2001)
    6. The adenovirus E1A oncoprotein recruits the cellular TRRAP/GCN5 histone acetyltransferase complex. (PubMed id 12743606)1, 2, 9 Lang S.E. and Hearing P. (Oncogene 2003)
    7. The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc. (PubMed id 10611234)1, 2, 9 McMahon S.B.... Cole M.D. (Mol. Cell. Biol. 2000)
    8. Transcriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transition. (PubMed id 17967892)1, 2, 9 DeRan M.... Zhao J. (Mol. Cell. Biol. 2008)
    9. BAF53 forms distinct nuclear complexes and functions as a critical c- Myc-interacting nuclear cofactor for oncogenic transformation. (PubMed id 11839798)1, 2, 9 Park J.... Cole M.D. (Mol. Cell. Biol. 2002)
    10. Exome sequencing identifies GRIN2A as frequently mutated in melanoma. (PubMed id 21499247)1, 2 Wei X.... Samuels Y. (Nat. Genet. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8295 HGNC: 12347 AceView: TRRAP Ensembl:ENSG00000196367 euGenes: HUgn8295
    ECgene: TRRAP Kegg: 8295 H-InvDB: TRRAP

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRRAP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRRAP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRRAP gene:
    Search GeneIP for patents involving TRRAP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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