TRRAP Gene
protein-coding GIFtS: 60
GCID: GC07P098475
|
|
transformation/transcription domain-associated protein
| |
Aliases
for TRRAP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transformation/Transcription Domain-Associated Protein1 2 | | Tra1 Homolog2 3 | | PAF4001 2 3 | | 350/400 KDa PCAF-Associated Factor2 3 | | TR-AP1 2 | | PAF350/4002 3 | | Tra11 2 | | STAF402 3 |
Export aliases for TRRAP gene to outside databasesPrevious GC identifers: GC07P097010 GC07P098073 GC07P098087 GC07P098120 GC07P098314 GC07P093109 |
Summaries
for TRRAP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TRRAP:
This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. Theencoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role intranscription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role inseveral types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multipleisoforms have been observed for this gene. (provided by RefSeq, Sep 2011)
UniProtKB/Swiss-Prot: TRRAP_HUMAN, Q9Y4A5Function: Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferaseactivity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histoneacetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a centralrole in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-,E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirusE1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factorssuch as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably notrequired in the steps following histone acetylation in processes of transcription activation. May be required for themitotic checkpoint and normal cell cycle progression
Gene Wiki entry for TRRAP (Transformation/transcription domain-associated protein)
|
Genomic Views
for TRRAP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TRRAP gene promoter:
HOXA9 HOXA9B p53 RREB-1 Pax-6 Meis-1b PPAR-gamma1 PPAR-gamma2 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRRAP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRRAP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q21.2-q22.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q21.2-q22.1TRRAP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P098475: view genomic region
(about GC identifiers)
Start:
|
98,475,556 bp from pter |
End:
|
98,610,866 bp from pter |
Size:
|
135,311 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 97,832,168-97,966,885 |
|
Proteins
for TRRAP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TRRAP_HUMAN, Q9Y4A5 (See
protein sequence)Recommended Name: Transformation/transcription domain-associated protein Size: 3859 amino acids; 437600 Da
Subunit: Interacts with MYC, E2F1 and E2F4 transcription factors. Interacts directly with p53/TP53. Interacts withGCN5L2. Component of various HAT complexes. Component of the PCAF complex, at least composed of TADA2L/ADA2, SUPT3H,TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP. Component ofthe TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135,TAF5/TAFII100, GCN5L2/GCN5, TAF10 and TRRAP. Component of the NuA4 histone acetyltransferase complex which containsthe catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49,RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. Componentof the STAGA complex, at least composed of SUPT3H, GCN5L2, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAPand TAF9. The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed ofATXN7L3, ENY2 and USP22. Component of the BAF53 complex, at least composed of BAF53A, RUVBL1, SMARCA4/BRG1, and TRRAP,which preferentially acetylates histone H4 (and H2A) within nucleosomes. Interacts with NPAT. Interaction with TELO2AND TTI1
Subcellular location: Nucleus
Sequence caution: Sequence=AAC62433.1; Type=Erroneous gene model prediction;
Secondary accessions: A4D265 O75218 Q9Y631 Q9Y6H4Alternative splicing: 2 isoforms: Q9Y4A5-1 Q9Y4A5-2 Explore the universe of human proteins at neXtProt for TRRAP: NX_Q9Y4A5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y4A5
TRRAP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001231509.1 NP_003487.1
ENSEMBL proteins: ENSP00000401107 ENSP00000352925 ENSP00000347733 ENSP00000403708 ENSP00000394645
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
TRRAP for ontologies About GeneDecksing
TRRAP Antibody Products:
Assay Products for TRRAP: |
Protein
Domains /
Families
for TRRAP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRRAP for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q9Y4A5ProtoNet protein and cluster: Q9Y4A5 2 Blocks protein families: IPB000403 Phosphatidylinositol 3- and 4-kinase IPB003151 PIK-related kinase
UniProtKB/Swiss-Prot: TRRAP_HUMAN, Q9Y4A5Domain: The PI3K/PI4K domain is required for the recruitment of HAT complexes, and the MYC-dependent transactivation.Although it is strongly related to the PI3/PI4-kinase family, it lacks the typical motifs that constitute thecatalytic site of PI3/PI4-kinase proteins, and lacks such activitySimilarity: Belongs to the PI3/PI4-kinase family. TRA1 subfamilySimilarity: Contains 1 FAT domainSimilarity: Contains 1 FATC domainSimilarity: Contains 1 PI3K/PI4K domain |
Function
for TRRAP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TRRAP_HUMAN, Q9Y4A5Function: Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferaseactivity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histoneacetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a centralrole in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-,E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirusE1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factorssuch as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably notrequired in the steps following histone acetylation in processes of transcription activation. May be required for themitotic checkpoint and normal cell cycle progression Genatlas biochemistry entry for TRRAP:transformation/transcription domain associated protein,434kDa,essential cofactor for the c-Myc and E2F oncoproteins
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRRAP (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRRAP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TRRAP (NM_003496) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRRAP | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRRAP |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRRAP |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003712 | transcription cofactor activity |
IDA | 11418595 | | GO:0003713 | transcription coactivator activity |
IEA | -- | | GO:0005515 | protein binding |
IPI | -- | | GO:0016773 | phosphotransferase activity, alcohol group as acceptor |
IEA | -- |
TRRAP for ontologies About GeneDecksing
6 GenomeRNAi human phenotypes for TRRAP:
Animal Models:
Mouse knock-outs for TRRAP: Trraptm1.1Zqw Trraptm1Zqw
2 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Trrap):
TRRAP for phenotypes About GeneDecksing
|
Pathways & Interactions
for TRRAP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Chromatin Regulation / Acetylation | | | 2 | Cell Cycle / Checkpoint Control | | | 3 | Regulation of Wnt-mediated beta catenin signaling and target gene transcription | | | 4 | Validated targets of C-MYC transcriptional activation | | | 5 | C-MYC pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for TRRAP
2 
Cell Signaling Technology (CST) Pathways for TRRAP
5  BioSystems Pathways for TRRAP
TRRAP for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRRAP
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/701 Interacting proteins for TRRAP (Q9Y4A51, 2, 3 ENSP000003477334) via UniProtKB, MINT, STRING, and/or I2D (see all 701)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
TRRAP for ontologies About GeneDecksing
|
Drugs & Compounds
for TRRAP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TRRAP for compounds About GeneDecksing
 Browse Tocris compounds for TRRAP
1 Novoseek chemical compound relationship for TRRAP gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| polypropylene glycol |
73.2 |
2 |
12743606 (1), 16880778 (1) |
Search CenterWatch for drugs/clinical trials and news about TRRAP
|
Transcripts
for TRRAP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TRRAP gene (2 alternative transcripts): NM_001244580.1 NM_003496.3 Unigene Cluster for TRRAP: Transformation/transcription domain-associated protein Hs.203952 [show with all ESTs]Unigene Representative Sequence: NM_0012445806 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000417523 ENST00000359863(uc003upp.3) ENST00000355540(uc011kis.2)
ENST00000446306 ENST00000456197(uc003upr.3) ENST00000480695
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRRAP (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRRAP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TRRAP (NM_003496) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRRAP | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRRAP |
Additional cDNA sequence: AB209489.1 AF076974.1 AF110377.1 AL050077.1 BC032759.1 BC141939.1 7 DOTS entries: DT.95277995 DT.100851361 DT.100777288 DT.100777290 DT.75179516 DT.91854074 DT.91889772 24/213 AceView cDNA sequences (see all 213): BM905882 AI247550 AL706886 AW027295 BM802455 BQ436958 AF076974 BM665438 BU727573 CD245014 BG258802 NM_003496 BM711519 BQ653146 BF432365 CF272192 BE467099 BQ049770 R18144 AF110377 AI369627 BU159147 BQ653171 BQ643828
GeneLoc Exon Structure
5/28 Alternative Splicing Database (ASD) splice patterns (SP) for TRRAP (see all 28) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21a | · | 21b | · | 21c | ^ | 22 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29a | · | 29b | ^ | 30a | · | 30b | · | 30c | ^ | 31 | ^ | 32a | · | 32b | · | 32c | ^ | 33a | · | 33b | · | 33c | ^ | 34a | · | 34b | ^ | 35a | · | 35b | ^ | 36a | · | 36b | ^ | 37a | · | 37b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 38a | · | 38b | ^ | 39a | · | 39b | · | 39c | ^ | 40 | ^ | 41a | · | 41b | ^ | 42a | · | 42b | ^ | 43 | ^ | 44a | · | 44b | ^ | 45 | ^ | 46 | ^ | 47a | · | 47b | · | 47c | ^ | 48 | ^ | 49 | ^ | 50 | ^ | 51 | ^ | 52 | ^ | 53 | ^ | 54 | ^ | 55 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 56 | ^ | 57 | ^ | 58 | ^ | 59 | ^ |
|---|
|
| SP1: | | | | | | | | | |
| SP2: | | | | | | | | | |
| SP3: | | | | | | | | | |
| SP4: | | | | | | | | | |
| SP5: | | | | | | | | |
ECgene alternative splicing isoforms for TRRAP
|
Expression
for TRRAP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRRAP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGTTTTTC
About this image
See TRRAP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRRAP
SOURCE GeneReport for Unigene cluster: Hs.203952
SABiosciences Custom PCR Arrays for TRRAP
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRRAP
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRRAP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRRAP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRRAP | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRRAP |
Orthologs
for TRRAP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TRRAP gene from 10/32 species (see all 32) About this table
ENSEMBL Gene Tree for TRRAP (if available)
TreeFam Gene Tree for TRRAP (if available) |
Paralogs
for TRRAP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TRRAP gene
TRRAP for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TRRAP
PGOHUM00000238920
|
Genomic Variants
for TRRAP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TRRAP (98475556 - 98610866 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TRRAP: --
Human Gene Mutation Database (HGMD): TRRAP
| 1 SABiosciences Cancer Mutation PCR Assay for TRRAP: | Cosmic Id | AA Change |
|---|
| 107494 | p.S722F |
|
| 1 SABiosciences qBiomarker Copy Number PCR Array containing TRRAP: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRRAP |
|
Disorders
/ Diseases
for TRRAP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TRRAP for disorders About GeneDecksing
OMIM gene information: 603015
OMIM disorders: --
UniProtKB/Swiss-Prot: TRRAP_HUMAN, Q9Y4A5
Note=TRRAP mutation Phe-722 has been frequently found in cutaneous malignant melanoma, suggesting that TRRAPmay play a role in the pathogenesis of melanoma (PubMed:21499247)
19  diseases for TRRAP: About MalaCardsdosage-sensitive sex reversal sex reversal glioblastoma williams syndrome
liver cirrhosis retinal degeneration hepatocellular carcinoma retinitis
lung cancer breast cancer schizophrenia thyroiditis
melanoma adenocarcinoma carcinoma pancreatitis
hepatitis alcoholism ischemia
2 Novoseek disease relationships for TRRAP gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| retinoblastoma |
24 |
1 |
11781841 (1) |
| cancer |
0 |
1 |
17694078 (1) |
Human Genome Epidemiology (HuGE) Navigator: TRRAP (1 document)
Export disorders for TRRAP gene to outside databases
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Publications
for TRRAP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRRAP gene, integrated from 9 sources (see all 122):
(articles sorted by number of sources associating them with TRRAP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. (PubMed id 9708738)1, 2, 3, 9 McMahon S.B.... Cole M.D. (1998)
- The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily. (PubMed id 9885574)1, 2, 3 Vassilev A....Nakatani Y. (1998)
- c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation. (PubMed id 12660246)1, 2, 9 Liu X.... Martinez E. (2003)
- E2F transcriptional activation requires TRRAP and GCN5 cofactors. (PubMed id 11418595)1, 2, 9 Lang S.E.... Hearing P. (2001)
- The ATM-related domain of TRRAP is required for histone acetyltransferase recruitment and Myc-dependent oncogenesis. (PubMed id 11445536)1, 2, 9 Park J.... Cole M.D. (2001)
- The adenovirus E1A oncoprotein recruits the cellular TRRAP/GCN5 histone acetyltransferase complex. (PubMed id 12743606)1, 2, 9 Lang S.E. and Hearing P. (2003)
- The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc. (PubMed id 10611234)1, 2, 9 McMahon S.B.... Cole M.D. (2000)
- Transcriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transition. (PubMed id 17967892)1, 2, 9 DeRan M.... Zhao J. (2008)
- BAF53 forms distinct nuclear complexes and functions as a critical c- Myc-interacting nuclear cofactor for oncogenic transformation. (PubMed id 11839798)1, 2, 9 Park J.... Cole M.D. (2002)
- Exome sequencing identifies GRIN2A as frequently muta ted in melanoma. (PubMed id 21499247)1, 2 Wei X....Samuels Y. (2011)
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External Searches for TRRAP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing TRRAP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRRAP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TRRAP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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|
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About This Section
| Patent Information for TRRAP gene:
Search GeneIP for patents involving TRRAP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TRRAP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TRRAP | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRRAP | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRRAP | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TRRAP | | OriGene 3'-UTR Clone for TRRAP | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRRAP | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRRAP | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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