Aliases for TRPV5 Gene
External Ids for TRPV5 Gene
Previous HGNC Symbols for TRPV5 Gene
Previous GeneCards Identifiers for TRPV5 Gene
This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level. [provided by RefSeq, Jul 2008]
GeneCards Summary for TRPV5 Gene
TRPV5 (Transient Receptor Potential Cation Channel Subfamily V Member 5) is a Protein Coding gene. Diseases associated with TRPV5 include Hypervitaminosis D and Aromatase Deficiency. Among its related pathways are Ion channel transport and CREB Pathway. GO annotations related to this gene include calmodulin binding and calcium channel activity. An important paralog of this gene is TRPV6.
UniProtKB/Swiss-Prot for TRPV5 Gene
Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:11549322, PubMed:18768590). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (PubMed:11549322, PubMed:18768590). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).
Vanilloids are a group of compounds, structurally related to capsaicin, thought to exert their actions via vanilloid receptors. The vanilloid receptor family (TRPV) is a member of the transient receptor potential (TRP) superfamily of ion channels, and have six members (TRPV1-6).