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Aliases for TRPV2 Gene

Aliases for TRPV2 Gene

  • Transient Receptor Potential Cation Channel, Subfamily V, Member 2 2 3
  • Vanilloid Receptor-Like Protein 1 3 4
  • Osm-9-Like TRP Channel 2 3 4
  • OTRPC2 3 4
  • VRL-1 3 4
  • VRL1 3 6
  • VRL 3 4
  • Transient Receptor Potential Cation Channel Subfamily V Member 2 3
  • TrpV2 4

External Ids for TRPV2 Gene

Summaries for TRPV2 Gene

Entrez Gene Summary for TRPV2 Gene

  • This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRPV2 Gene

TRPV2 (Transient Receptor Potential Cation Channel, Subfamily V, Member 2) is a Protein Coding gene. Diseases associated with TRPV2 include dentin sensitivity. Among its related pathways are CREB Pathway and Ion channel transport. GO annotations related to this gene include calcium channel activity and ion channel activity. An important paralog of this gene is TRPV6.

UniProtKB/Swiss-Prot for TRPV2 Gene

  • Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.

Tocris Summary for TRPV2 Gene

  • Vanilloids are a group of compounds, structurally related to capsaicin, thought to exert their actions via vanilloid receptors. The vanilloid receptor family (TRPV) is a subgroup of the transient receptor potential (TRP) superfamily of ion channels, and six members (TRPV1-6) have so far been identified. The six vanilloid receptor members have been divided into four groups on the basis of structure and function: TRPV1/2, TRPV3, TRPV4 and TRPV5/6. TRPV1-4 are thermosensitive, non-selective cation channels that exist as tetrameric complexes. They are activated by a range of stimuli including heat, protons, lipids and changes in osmolarity or pressure. TRPV5-6 are calcium selective channels that are involved in the absorption and reabsorption of calcium across intestinal and renal epithelia. It has been proposed that cannabinoids are endogenous ligands for vanilloid receptors. Furthermore, adenosine has been shown to be an endogenous TRPV1 ligand and TRPV4 is activated by anandamide and arachidonic acid.

Gene Wiki entry for TRPV2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRPV2 Gene

Genomics for TRPV2 Gene

Genomic Location for TRPV2 Gene

Start:
16,415,542 bp from pter
End:
16,437,003 bp from pter
Size:
21,462 bases
Orientation:
Plus strand

Genomic View for TRPV2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRPV2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRPV2 Gene

Regulatory Elements for TRPV2 Gene

Proteins for TRPV2 Gene

  • Protein details for TRPV2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5S1-TRPV2_HUMAN
    Recommended name:
    Transient receptor potential cation channel subfamily V member 2
    Protein Accession:
    Q9Y5S1
    Secondary Accessions:
    • A6NML2
    • A8K0Z0
    • Q9Y670

    Protein attributes for TRPV2 Gene

    Size:
    764 amino acids
    Molecular mass:
    85981 Da
    Quaternary structure:
    • Homotetramer (Probable). Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with SLC50A1; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation (By similarity).

    Three dimensional structures from OCA and Proteopedia for TRPV2 Gene

neXtProt entry for TRPV2 Gene

Proteomics data for TRPV2 Gene at MOPED

Post-translational modifications for TRPV2 Gene

Other Protein References for TRPV2 Gene

No data available for DME Specific Peptides for TRPV2 Gene

Domains for TRPV2 Gene

Gene Families for TRPV2 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing
  • TRP :Voltage-gated ion channels / Transient receptor potential cation channels
IUPHAR :

Suggested Antigen Peptide Sequences for TRPV2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5S1

UniProtKB/Swiss-Prot:

TRPV2_HUMAN
Family:
  • Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily.:
    • Q9Y5S1
Similarity:
  • Contains 6 ANK repeats.:
    • Q9Y5S1
genes like me logo Genes that share domains with TRPV2: view

Function for TRPV2 Gene

Molecular function for TRPV2 Gene

UniProtKB/Swiss-Prot Function: Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.

Gene Ontology (GO) - Molecular Function for TRPV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity TAS 10201375
GO:0005261 cation channel activity IDA 10201375
GO:0005262 calcium channel activity IEA --
GO:0005515 protein binding --
GO:0015075 ion transmembrane transporter activity TAS 10201375
genes like me logo Genes that share ontologies with TRPV2: view
genes like me logo Genes that share phenotypes with TRPV2: view

Animal Models for TRPV2 Gene

MGI Knock Outs for TRPV2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TRPV2 Gene

Localization for TRPV2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRPV2 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasm. Melanosome. Note=Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRPV2 Gene COMPARTMENTS Subcellular localization image for TRPV2 gene
Compartment Confidence
plasma membrane 5
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TRPV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10201375
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with TRPV2: view

Pathways for TRPV2 Gene

genes like me logo Genes that share pathways with TRPV2: view

Pathways by source for TRPV2 Gene

Gene Ontology (GO) - Biological Process for TRPV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 10201375
GO:0006811 ion transport --
GO:0007600 sensory perception TAS 10201375
GO:0009266 response to temperature stimulus IDA 10201375
GO:0009408 response to heat IEA --
genes like me logo Genes that share ontologies with TRPV2: view

Compounds for TRPV2 Gene

(5) Tocris Compounds for TRPV2 Gene

Compound Action Cas Number
5-Iodoresiniferatoxin Potent, silent TRPV1 antagonist [535974-91-5]
AMG 9810 Potent and selective, competitive antagonist of TRPV1 [545395-94-6]
Anandamide Endogenous CB receptor agonist [94421-68-8]
Capsazepine Vanilloid receptor antagonist. Also activator of ENaCdelta [138977-28-3]
HC 067047 Potent and selective TRPV4 antagonist [883031-03-6]

(2) HMDB Compounds for TRPV2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Cyclic AMP
  • Cyclic AMP
60-92-4

(9) IUPHAR Ligand for TRPV2 Gene

Ligand Type Action Affinity Pubmed IDs
ruthenium red Channel blocker None
TRIM Channel blocker None
SKF96365 Channel blocker None
amiloride Channel blocker None
Delta9-tetrahydrocannabinol Channel blocker None
cannabidiol Channel blocker None
La3+ Channel blocker None
diphenylboronic anhydride Activator None
probenecid Activator None

(2) Novoseek inferred chemical compound relationships for TRPV2 Gene

Compound -log(P) Hits PubMed IDs
capsaicin 70.6 2
calcium 25.8 6
genes like me logo Genes that share compounds with TRPV2: view

Transcripts for TRPV2 Gene

Unigene Clusters for TRPV2 Gene

Transient receptor potential cation channel, subfamily V, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRPV2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18
SP1: -
SP2:
SP3: - -
SP4: - -
SP5:
SP6: - -
SP7:
SP8:
SP9: -

Relevant External Links for TRPV2 Gene

GeneLoc Exon Structure for
TRPV2
ECgene alternative splicing isoforms for
TRPV2

Expression for TRPV2 Gene

mRNA expression in normal human tissues for TRPV2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRPV2 Gene

This gene is overexpressed in Whole Blood (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRPV2 Gene

SOURCE GeneReport for Unigene cluster for TRPV2 Gene Hs.279746

genes like me logo Genes that share expressions with TRPV2: view

No data available for mRNA Expression by UniProt/SwissProt for TRPV2 Gene

Orthologs for TRPV2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRPV2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRPV2 35
  • 99.3 (n)
  • 98.95 (a)
TRPV2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRPV2 35
  • 82.31 (n)
  • 78.27 (a)
TRPV2 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRPV2 35
  • 85.41 (n)
  • 84.36 (a)
TRPV2 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trpv2 35
  • 82.05 (n)
  • 81.56 (a)
Trpv2 16
Trpv2 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRPV2 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRPV2 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trpv2 35
  • 80.52 (n)
  • 78.75 (a)
chicken
(Gallus gallus)
Aves TRPV2 35
  • 61.82 (n)
  • 57.2 (a)
TRPV2 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRPV2 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trpv1 35
  • 59.14 (n)
  • 53.12 (a)
zebrafish
(Danio rerio)
Actinopterygii trpv1 36
  • 39 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta iav 36
  • 14 (a)
ManyToMany
nan 36
  • 20 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ocr-1 36
  • 18 (a)
ManyToMany
ocr-2 36
  • 17 (a)
ManyToMany
ocr-3 36
  • 19 (a)
ManyToMany
ocr-4 36
  • 21 (a)
ManyToMany
osm-9 36
  • 16 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
ManyToMany
-- 36
  • 20 (a)
ManyToMany
Species with no ortholog for TRPV2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRPV2 Gene

ENSEMBL:
Gene Tree for TRPV2 (if available)
TreeFam:
Gene Tree for TRPV2 (if available)

Paralogs for TRPV2 Gene

Paralogs for TRPV2 Gene

Selected SIMAP similar genes for TRPV2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TRPV2: view

Variants for TRPV2 Gene

Sequence variations from dbSNP and Humsavar for TRPV2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs8121 -- 16,422,654(-) TTGAC(C/T)CCGTC reference, synonymous-codon
rs14039 -- 16,433,678(-) TCATC(A/C/G)GGGCT reference, synonymous-codon, intron-variant
rs1129235 -- 16,422,691(+) TCGAC(A/C)GGGAC reference, synonymous-codon
rs3813768 - 16,417,718(-) GGCCT(C/G)CATCT missense, reference
rs3813769 -- 16,415,618(-) GGAGA(A/G)CGGGA utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TRPV2 Gene

Variant ID Type Subtype PubMed ID
esv2715702 CNV Deletion 23290073

Relevant External Links for TRPV2 Gene

HapMap Linkage Disequilibrium report
TRPV2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRPV2 Gene

Disorders for TRPV2 Gene

(1) MalaCards Diseases for TRPV2 Gene

Search for TRPV2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for TRPV2 Gene

genes like me logo Genes that share disorders with TRPV2: view

No data available for UniProtKB/Swiss-Prot for TRPV2 Gene

Publications for TRPV2 Gene

  1. A capsaicin-receptor homologue with a high threshold for noxious heat. (PMID: 10201375) Caterina M.J. … Julius D. (Nature 1999) 2 3 4 23
  2. Capsaicin receptor in the pain pathway. (PMID: 10887936) Tominaga M. … Julius D. (Jpn. J. Pharmacol. 2000) 3 23
  3. Role and regulation of TRP channels in neutrophil granulocytes. (PMID: 12765698) Heiner I. … LA1ckhoff A. (Cell Calcium 2003) 3 23
  4. Transient receptor potential vanilloid type 2 (TRPV2) expression in normal urothelium and in urothelial carcinoma of human bladder: correlation with the pathologic stage. (PMID: 17977643) Caprodossi S. … Santoni G. (Eur. Urol. 2008) 3 23
  5. Transient receptor potential vanilloid 1, vanilloid 2 and melastatin 8 immunoreactive nerve fibers in human skin from individuals with and without Norrbottnian congenital insensitivity to pain. (PMID: 19482060) Axelsson H.E. … Zygmunt P.M. (Neuroscience 2009) 3 23

Products for TRPV2 Gene

Sources for TRPV2 Gene

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