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Aliases for TRPV2 Gene

Aliases for TRPV2 Gene

  • Transient Receptor Potential Cation Channel Subfamily V Member 2 2 3
  • Transient Receptor Potential Cation Channel, Subfamily V, Member 2 2 3 5
  • Vanilloid Receptor-Like Protein 1 3 4
  • Osm-9-Like TRP Channel 2 3 4
  • OTRPC2 3 4
  • VRL-1 3 4
  • VRL 3 4
  • TrpV2 4
  • VRL1 3

External Ids for TRPV2 Gene

Previous GeneCards Identifiers for TRPV2 Gene

  • GC17P016680
  • GC17P017429
  • GC17P016261
  • GC17P016519
  • GC17P016259
  • GC17P016318
  • GC17P016186

Summaries for TRPV2 Gene

Entrez Gene Summary for TRPV2 Gene

  • This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRPV2 Gene

TRPV2 (Transient Receptor Potential Cation Channel Subfamily V Member 2) is a Protein Coding gene. Diseases associated with TRPV2 include Retina Lymphoma and Dentin Sensitivity. Among its related pathways are Ion channel transport and Development Endothelin-1/EDNRA signaling. GO annotations related to this gene include ion channel activity and cation channel activity. An important paralog of this gene is TRPV1.

UniProtKB/Swiss-Prot for TRPV2 Gene

  • Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.

Tocris Summary for TRPV2 Gene

  • Vanilloids are a group of compounds, structurally related to capsaicin, thought to exert their actions via vanilloid receptors. The vanilloid receptor family (TRPV) is a member of the transient receptor potential (TRP) superfamily of ion channels, and have six members (TRPV1-6).

Gene Wiki entry for TRPV2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRPV2 Gene

Genomics for TRPV2 Gene

Regulatory Elements for TRPV2 Gene

Enhancers for TRPV2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRPV2 on UCSC Golden Path with GeneCards custom track

Promoters for TRPV2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRPV2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRPV2 Gene

Chromosome:
17
Start:
16,415,542 bp from pter
End:
16,437,003 bp from pter
Size:
21,462 bases
Orientation:
Plus strand

Genomic View for TRPV2 Gene

Genes around TRPV2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRPV2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRPV2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRPV2 Gene

Proteins for TRPV2 Gene

  • Protein details for TRPV2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5S1-TRPV2_HUMAN
    Recommended name:
    Transient receptor potential cation channel subfamily V member 2
    Protein Accession:
    Q9Y5S1
    Secondary Accessions:
    • A6NML2
    • A8K0Z0
    • Q9Y670

    Protein attributes for TRPV2 Gene

    Size:
    764 amino acids
    Molecular mass:
    85981 Da
    Quaternary structure:
    • Homotetramer (Probable). Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with SLC50A1; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation (By similarity).

    Three dimensional structures from OCA and Proteopedia for TRPV2 Gene

neXtProt entry for TRPV2 Gene

Proteomics data for TRPV2 Gene at MOPED

Post-translational modifications for TRPV2 Gene

Other Protein References for TRPV2 Gene

No data available for DME Specific Peptides for TRPV2 Gene

Domains & Families for TRPV2 Gene

Suggested Antigen Peptide Sequences for TRPV2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5S1

UniProtKB/Swiss-Prot:

TRPV2_HUMAN :
  • Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily.
  • Contains 6 ANK repeats.
Family:
  • Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily.
Similarity:
  • Contains 6 ANK repeats.
genes like me logo Genes that share domains with TRPV2: view

Function for TRPV2 Gene

Molecular function for TRPV2 Gene

UniProtKB/Swiss-Prot Function:
Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.

Gene Ontology (GO) - Molecular Function for TRPV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity TAS 10201375
genes like me logo Genes that share ontologies with TRPV2: view
genes like me logo Genes that share phenotypes with TRPV2: view

Animal Models for TRPV2 Gene

MGI Knock Outs for TRPV2:

Animal Model Products

  • Taconic Biosciences Mouse Models for TRPV2

miRNA for TRPV2 Gene

miRTarBase miRNAs that target TRPV2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRPV2 Gene

Localization for TRPV2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRPV2 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasm. Melanosome. Note=Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRPV2 Gene COMPARTMENTS Subcellular localization image for TRPV2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
endosome 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TRPV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0016020 membrane IEA --
GO:0032584 growth cone membrane IEA --
GO:0042470 melanosome IEA --
GO:0044297 cell body IEA --
genes like me logo Genes that share ontologies with TRPV2: view

Pathways & Interactions for TRPV2 Gene

genes like me logo Genes that share pathways with TRPV2: view

Pathways by source for TRPV2 Gene

Gene Ontology (GO) - Biological Process for TRPV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007600 sensory perception TAS 10201375
GO:0034220 ion transmembrane transport TAS --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with TRPV2: view

No data available for SIGNOR curated interactions for TRPV2 Gene

Drugs & Compounds for TRPV2 Gene

(13) Drugs for TRPV2 Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amiloride Approved Pharma Channel blocker, blocker 47
Probenecid Approved Pharma Inhibition, Inhibitor 27
cyclic amp Experimental Pharma 0
cannabidiol Pharma Partial agonist, Agonist 0
La<sup>3+</sup> Pharma Pore Blocker 0

(5) Additional Compounds for TRPV2 Gene - From: IUPHAR and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Delta<sup>9</sup>-tetrahydrocannabinol
Partial agonist, Agonist
TRIM
Channel blocker
(E)-Capsaicin
404-86-4
AM 404
198022-70-7
Anandamide (in Tocrisolve 100)
94421-68-8

(5) Tocris Compounds for TRPV2 Gene

Compound Action Cas Number
(E)-Capsaicin Prototypic vanilloid receptor agonist 404-86-4
AM 404 Anandamide transport inhibitor 198022-70-7
Anandamide (in Tocrisolve 100) Endogenous CB receptor agonist (in water-soluble emulsion) 94421-68-8
Olvanil Potent vanilloid receptor agonist 58493-49-5
Resiniferatoxin Potent vanilloid receptor agonist 57444-62-9

(2) ApexBio Compounds for TRPV2 Gene

Compound Action Cas Number
HC-030031 TRPA1 channel blocker,potent and selective 349085-38-7
Probenecid 57-66-9
genes like me logo Genes that share compounds with TRPV2: view

Transcripts for TRPV2 Gene

Unigene Clusters for TRPV2 Gene

Transient receptor potential cation channel, subfamily V, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRPV2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18
SP1: -
SP2:
SP3: - -
SP4: - -
SP5:
SP6: - -
SP7:
SP8:
SP9: -

Relevant External Links for TRPV2 Gene

GeneLoc Exon Structure for
TRPV2
ECgene alternative splicing isoforms for
TRPV2

Expression for TRPV2 Gene

mRNA expression in normal human tissues for TRPV2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRPV2 Gene

This gene is overexpressed in Whole Blood (x6.8).

Protein differential expression in normal tissues from HIPED for TRPV2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.6), Adrenal (10.9), CD8 Tcells (8.6), Pancreas (7.8), and Placenta (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRPV2 Gene



SOURCE GeneReport for Unigene cluster for TRPV2 Gene Hs.279746

genes like me logo Genes that share expression patterns with TRPV2: view

Protein tissue co-expression partners for TRPV2 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TRPV2 Gene

Orthologs for TRPV2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRPV2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRPV2 35
  • 82.31 (n)
  • 78.27 (a)
TRPV2 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRPV2 35
  • 85.41 (n)
  • 84.36 (a)
TRPV2 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trpv2 35
  • 82.05 (n)
  • 81.56 (a)
Trpv2 16
Trpv2 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRPV2 35
  • 99.3 (n)
  • 98.95 (a)
TRPV2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trpv2 35
  • 80.52 (n)
  • 78.75 (a)
oppossum
(Monodelphis domestica)
Mammalia TRPV2 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRPV2 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRPV2 35
  • 61.82 (n)
  • 57.2 (a)
TRPV2 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRPV2 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trpv1 35
  • 59.14 (n)
  • 53.12 (a)
zebrafish
(Danio rerio)
Actinopterygii trpv1 36
  • 39 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta iav 36
  • 14 (a)
ManyToMany
nan 36
  • 20 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ocr-1 36
  • 18 (a)
ManyToMany
ocr-2 36
  • 17 (a)
ManyToMany
ocr-3 36
  • 19 (a)
ManyToMany
ocr-4 36
  • 21 (a)
ManyToMany
osm-9 36
  • 16 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
ManyToMany
-- 36
  • 20 (a)
ManyToMany
Species with no ortholog for TRPV2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRPV2 Gene

ENSEMBL:
Gene Tree for TRPV2 (if available)
TreeFam:
Gene Tree for TRPV2 (if available)

Paralogs for TRPV2 Gene

Paralogs for TRPV2 Gene

(5) SIMAP similar genes for TRPV2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TRPV2: view

Variants for TRPV2 Gene

Sequence variations from dbSNP and Humsavar for TRPV2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs3813768 - 16,417,718(-) GGCCT(C/G)CATCT reference, missense
rs8071215 - 16,436,885(+) GTCCA(A/G)CTGAT downstream-variant-500B, reference, missense, utr-variant-3-prime
rs8121 -- 16,422,654(-) TTGAC(C/T)CCGTC reference, synonymous-codon
rs14039 -- 16,433,678(-) TCATC(A/C/G/T)GGGCT intron-variant, reference, synonymous-codon
rs1129235 -- 16,422,691(+) TCGAC(A/C)GGGAC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TRPV2 Gene

Variant ID Type Subtype PubMed ID
esv2715702 CNV Deletion 23290073

Variation tolerance for TRPV2 Gene

Residual Variation Intolerance Score: 9.42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.87; 58.94% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TRPV2 Gene

Disorders for TRPV2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TRPV2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retina lymphoma
  • lymphoma of retina
dentin sensitivity
  • sensitive dentin
- elite association - COSMIC cancer census association via MalaCards
Search TRPV2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TRPV2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRPV2
genes like me logo Genes that share disorders with TRPV2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRPV2 Gene

Publications for TRPV2 Gene

  1. A capsaicin-receptor homologue with a high threshold for noxious heat. (PMID: 10201375) Caterina M.J. … Julius D. (Nature 1999) 2 3 4 23 67
  2. Clinical significance of transient receptor potential vanilloid 2 expression in human hepatocellular carcinoma. (PMID: 20113837) Liu G. … Miao X. (Cancer Genet. Cytogenet. 2010) 3 23
  3. Transient receptor potential vanilloid 1, vanilloid 2 and melastatin 8 immunoreactive nerve fibers in human skin from individuals with and without Norrbottnian congenital insensitivity to pain. (PMID: 19482060) Axelsson H.E. … Zygmunt P.M. (Neuroscience 2009) 3 23
  4. Up-regulation of TRPV1 in mononuclear cells of end-stage kidney disease patients increases susceptibility to N-arachidonoyl-dopamine (NADA)-induced cell death. (PMID: 19619644) Saunders C.I. … Geraghty D.P. (Biochim. Biophys. Acta 2009) 3 23
  5. Transient receptor potential vanilloid type 2 (TRPV2) expression in normal urothelium and in urothelial carcinoma of human bladder: correlation with the pathologic stage. (PMID: 17977643) Caprodossi S. … Santoni G. (Eur. Urol. 2008) 3 23

Products for TRPV2 Gene

Sources for TRPV2 Gene

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