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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRPV2 Gene

protein-coding   GIFtS: 55
GCID: GC17P016318

transient receptor potential cation channel, subfamily V,...
 Explore 11 diseases affiliated with
TRPV2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TRPV2    

Aliases
for TRPV2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Transient Receptor Potential Cation Channel, Subfamily V, Member 21 2     Vanilloid Receptor-Like Protein 12 3
VRL1 2 3     OTRPC22 3
VRL-11 2 3     Transient Receptor Potential Cation Channel Subfamily V Member 22
VRL11 2 5     TrpV23
Osm-9-Like TRP Channel 22 3     

External Ids:    HGNC: 180821   Entrez Gene: 513932   Ensembl: ENSG000001876887   OMIM: 6066765   UniProtKB: Q9Y5S13   

Export aliases for TRPV2 gene to outside databases

Previous GC identifers: GC17P016680 GC17P017429 GC17P016261 GC17P016519 GC17P016259 GC17P016186


Summaries
for TRPV2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TRPV2:
This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be
involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues
the channel may be activated by stimuli other than heat. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TRPV2_HUMAN, Q9Y5S1
Function: Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at
least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated
by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH

summary for TRPV2:
Vanilloids are a group of compounds, structurally related to capsaicin, thought to exert their actions via
vanilloid receptors. The vanilloid receptor family (TRPV) is a subgroup of the transient receptor potential
(TRP) superfamily of ion channels, and six members (TRPV1-6) have so far been identified. The six vanilloid
receptor members have been divided into four groups on the basis of structure and function: TRPV1/2, TRPV3,
TRPV4 and TRPV5/6. TRPV1-4 are thermosensitive, non-selective cation channels that exist as tetrameric
complexes. They are activated by a range of stimuli including heat, protons, lipids and changes in
osmolarity or pressure. TRPV5-6 are calcium selective channels that are involved in the absorption and
reabsorption of calcium across intestinal and renal epithelia. It has been proposed that cannabinoids are
endogenous ligands for vanilloid receptors. Furthermore, adenosine has been shown to be an endogenous TRPV1
ligand and TRPV4 is activated by anandamide and arachidonic acid.

Gene Wiki entry for TRPV2


Genomic Views
for TRPV2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRPV2 gene promoter:
         NF-1/L   NF-1   AML1a   AP-1   p300   POU6F1 (c2)   HNF-1A   HNF-1   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRPV2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRPV2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRPV2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

TRPV2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRPV2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P016318:  view genomic region     (about GC identifiers)

Start:
 16,318,856 bp from pter      End:
 16,340,317 bp from pter
Size:
 21,462 bases      Orientation:
 plus strand

Proteins
for TRPV2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TRPV2_HUMAN, Q9Y5S1 (See protein sequence)
Recommended Name: Transient receptor potential cation channel subfamily V member 2  
Size: 764 amino acids; 85981 Da
Subunit: Homotetramer (Probable). Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or
PRKAR2B) and ACBD3. Interacts with SLC50A1; the interaction probably occurs intracellularly and depends on TRPV2
N-glycosylation (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity). Cytoplasm (By similarity).
Melanosome. Note=Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity).
Identified by mass spectrometry in melanosome fractions from stage I to stage IV
1 PDB 3D structure from and Proteopedia for TRPV2:
2F37 (3D)    
Secondary accessions: A6NML2 A8K0Z0 Q9Y670

Explore the universe of human proteins at neXtProt for TRPV2: NX_Q9Y5S1

Post-translational modifications:

  • N-glycosylated (By similarity)1
  • Phosphorylated by PKA (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y5S1

    • TRPV2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_057197.2  
    ENSEMBL proteins: 
     ENSP00000342222   ENSP00000390014   ENSP00000464850   ENSP00000465609   ENSP00000466130  
     ENSP00000467593   ENSP00000463196  

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    Uscn Proteins for TRPV2

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005886plasma membrane IDA10201375
    GO:0005887integral to plasma membrane TAS10201375
    GO:0009986cell surface IEA--
    GO:0012505endomembrane system IEA--


    TRPV2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TRPV2

    Protein Domains /
    Families
    for TRPV2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TRPV2 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR024862 TRPV_channel
     IPR008347 TRPV1-4_channel
     IPR020683 Ankyrin_rpt-contain_dom
     IPR005821 Ion_trans_dom
     IPR004729 TRP_channel

    Graphical View of Domain Structure for InterPro Entry Q9Y5S1

    ProtoNet protein and cluster: Q9Y5S1

    UniProtKB/Swiss-Prot: TRPV2_HUMAN, Q9Y5S1
    Similarity: Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily
    Similarity: Contains 6 ANK repeats


    Function
    for TRPV2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TRPV2_HUMAN, Q9Y5S1
    Function: Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at
    least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated
    by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH

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    hsa-miR-370
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    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity TAS10201375
    GO:0005261cation channel activity IDA10201375
    GO:0005262calcium channel activity IEA--
    GO:0005515protein binding ----
    GO:0015075ion transmembrane transporter activity TAS10201375


    TRPV2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for TRPV2:
     Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-out Trpv2tm1Mijc for TRPV2
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Trpv2):
     cellular  growth/size  immune system  mortality/aging 

    TRPV2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TRPV2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1CREB Pathway
    		Intracellular Calcium Signaling0.50

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TRPV2
        Intracellular Calcium Signaling


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRPV2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for TRPV2 (Q9Y5S13 ENSP000003422224) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC50A1Q9BRV33, ENSP000003573894I2D: score=1 STRING: ENSP00000357389
    TRPV1Q8NER13, ENSP000001746214I2D: score=1 STRING: ENSP00000174621
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS10201375
    GO:0007600sensory perception TAS10201375
    GO:0009266response to temperature stimulus IDA10201375
    GO:0009408response to heat IEA--
    GO:0034220ion transmembrane transport ----


    TRPV2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TRPV2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRPV2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for TRPV2

    Compounds for TRPV2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CapsazepineVanilloid receptor antagonist. Also activator of ENaCdelta[138977-28-3]
    OlvanilPotent vanilloid receptor agonist[58493-49-5]
    ResiniferatoxinPotent vanilloid receptor agonist[57444-62-9]
    6-Iodonordihydrocapsaicin Potent, competitive vanilloid receptor antagonist --
    PPAHVNon-pungent vanilloid receptor agonist[175796-50-6]

    2 HMDB Compounds for TRPV2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    2 Novoseek chemical compound relationships for TRPV2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    capsaicin 70.6 2 10201375 (1), 14534154 (1)
    calcium 25.8 6 17154364 (2), 16533525 (2), 15249591 (1), 17673572 (1)

    Search CenterWatch for drugs/clinical trials and news about TRPV2 

    Transcripts
    for TRPV2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TRPV2 gene: 
    NM_016113.4  

    Unigene Cluster for TRPV2:

    Transient receptor potential cation channel, subfamily V, member 2
    Hs.279746  [show with all ESTs]
    Unigene Representative Sequence: AK126996
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338560(uc002gpy.3 uc002gpz.3) ENST00000455666 ENST00000583241
    ENST00000577277 ENST00000581560 ENST00000580788 ENST00000577865 ENST00000475513
    ENST00000493434 ENST00000577397

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    hsa-miR-370
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF103906.1 AF129112.1 AJ487963.1 AK001896.1 AK092443.1 AK126996.1 AK289705.1 BC018926.2 
    BC051305.1 

    13 DOTS entries:

    DT.114670  DT.100785231  DT.95195429  DT.101966272  DT.313866  DT.120994192  DT.100785227  DT.100785232 
    DT.120994191  DT.95195422  DT.100734243  DT.120994189  DT.120994193 

    24/210 AceView cDNA sequences (see all 210):

    AA741232 AI126236 BG765155 BQ064773 AA931978 CD370120 BF436096 AI917712 
    AI126953 BQ643949 AI305201 AI754077 AA121980 CF131306 BQ644054 BU838756 
    BX283653 AA992494 BQ653113 BF940288 BQ679954 AA281349 BQ645005 BI819175 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TRPV2 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18
    SP1:                                                                                                        -                                                   
    SP2:                                                                                                                                                            
    SP3:                    -     -                                                                                                                                 
    SP4:                    -     -                                                                                                                                 
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for TRPV2

    Expression
    for TRPV2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRPV2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGAGCAGACG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TRPV2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 7 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
    PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)
    PureStem™ progenitor W8 (Embryonic Progenitor Cell)

    See TRPV2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRPV2

    SOURCE GeneReport for Unigene cluster: Hs.279746
        SABiosciences Expression via Pathway-Focused PCR Array including TRPV2: 
              Neuronal Ion Channels in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for TRPV2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TRPV2 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TRPV21 transient receptor potential cation channel, subfamily more 61.77(n)
    57.2(a)    		   417603  XM_415848.3  XP_415848.2 
    lizard
    (Anolis carolinensis)    		 Reptilia TRPV26
    		 --
    		 50(a)
    		 1 ↔ 1
    		 AAWZ02039224(1048-8981)
    zebrafish
    (Danio rerio)    		 Actinopterygii trpv16
    		 transient receptor potential cation channel, subfa...
    		 39(a)
    		 1 → many
    		 5(43754941-43777138)
    fruit fly
    (Drosophila melanogaster)    		 Insecta nan6
    iav6
    		 inactive
    		 18(a)
    13(a)
    		 many ↔ many
    many ↔ many
    		 3L(14179349-14182748)
    X(6708151-6712189)
    worm
    (Caenorhabditis elegans)    		 Secernentea ocr-46
    ocr-36
    (see all 5)    		 Osm-9 and Capsaicin receptor-Related family member...
    Osm-9 and Capsaicin receptor-Related family member...
    (see all 5)    		 20(a)
    18(a)
    (see all 5)    		 many ↔ many
    many ↔ many
    (see all 5)    		 IV(7329609-7332800)
    X(15168652-15173551)


    ENSEMBL Gene Tree for TRPV2 (if available)
    TreeFam Gene Tree for TRPV2 (if available) 

    Paralogs
    for TRPV2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRPV2 gene
    TRPV52  TRPV62  TRPV12  TRPV32  TRPV42  
    6 SIMAP similar genes for TRPV2 using alignment to 7 protein entries:     TRPV2_HUMAN (see all proteins):
    FLJ00078    TRPV1    TRPV6    TRPV4    TRPV3    ECAC2

    TRPV2 for paralogs           About GeneDecksing



    Genomic Variants
    for TRPV2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/508 NCBI SNPs in TRPV2 are shown (see all 508)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1414454281,2
    		--16316959(+) GAGGCA/GGAGGT 1 -- us2k10--------
    rs1133534501,2
    		--16316968(+) GTTGCG/AGCGAG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1843811471,2
    		--16316998(+) CTCCAA/GCCTGG 1 -- us2k10--------
    rs1392520951,2
    		--16317008(+) GGCAAA/CAAGAA 1 -- us2k10--------
    rs577287281,2
    		C--16317030(+) AAAAAA/-GAAAG 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1441252321,2
    		--16317266(+) TCCCAA/GGTTTA 1 -- us2k10--------
    rs1473212931,2
    		--16317333(+) CGCCTA/GGCTAT 1 -- us2k10--------
    rs1409871411,2
    		--16317363(+) AAATGG/TGGTTT 1 -- us2k10--------
    rs1448259361,2
    		--16317393(+) GTCTCA/GAATTC 1 -- us2k10--------
    rs1900552201,2
    		--16317414(+) GTGATC/TCACCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TRPV2 (16318856 - 16340317 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TRPV2: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for TRPV2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TRPV2 for disorders           About GeneDecksing

    OMIM gene information: 606676    OMIM disorders: --

    11 diseases for TRPV2:    About MalaCards
    dermatographia    dentin sensitivity    insensitivity to pain    kidney disease
    hepatoblastoma    hepatocellular carcinoma    prostate cancer    cerebritis
    prostatitis    carcinoma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for TRPV2:
    Dentin sensitivity

    Export disorders for TRPV2 gene to outside databases

    Publications
    for TRPV2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRPV2 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with TRPV2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A capsaicin-receptor homologue with a high threshold for noxious heat. (PubMed id 10201375)1, 2, 3, 9 Caterina M.J.... Julius D. (1999)
    2. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
    3. Crystal structure of the human TRPV2 channel ankyrin repeat domain. (PubMed id 16882997)1, 2 McCleverty C.J....Kreusch A. (2006)
    4. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. (PubMed id 16382100)1, 3 Clapham D.E....Schultz G. (2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Clinical significance of transient receptor potential vanilloid 2 expression in human hepatocellular carcinoma. (PubMed id 20113837)1, 9 Liu G....Miao X. (2010)
    8. Expression of transient receptor potential vanilloid 1 (TRPV1) and 2 (TRPV2) in human peripheral blood. (PubMed id 16777226)1, 9 Saunders C.I....Geraghty D.P. (2007)
    9. Transient receptor potential vanilloid 1, vanilloid 2 and melastatin 8 immunoreactive nerve fibers in human skin from individuals wi th and without Norrbottnian congenital insensitivity to pain. (PubMed id 19482060)1, 9 Axelsson H.E....Zygmunt P.M. (2009)
    10. Transient receptor potential vanilloid type 2 (TRPV2) expression in normal urothelium and in urothelial carcinoma of human bladder: correlation with the pathologic stage. (PubMed id 17977643)1, 9 Caprodossi S....Santoni G. (2008)

    External Searches for TRPV2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TRPV2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51393 HGNC: 18082 AceView: TRPV2.1 Ensembl:ENSG00000187688 euGenes: HUgn51393
    ECgene: TRPV2 H-InvDB: TRPV2

    Other Databases showing TRPV2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TRPV2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRPV2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TRPV2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TRPV2 gene:
    Search GeneIP for patents involving TRPV2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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