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TRPV1 Gene

protein-coding   GIFtS: 70
GCID: GC17M003471

Transient Receptor Potential Cation Channel, Subfamily V,...

(Previous name: vanilloid receptor subtype 1)
(Previous symbol: VR1)
  See TRPV1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transient Receptor Potential Cation Channel, Subfamily V, Member 11 2     Transient Receptor Potential Cation Channel Subfamily V Member 12
VR11 2 3 5     Transient Receptor Potential Vanilloid 1a2
Vanilloid Receptor Subtype 11 2     Transient Receptor Potential Vanilloid 1b2
Capsaicin Receptor2 3     TrpV13
Osm-9-Like TRP Channel 12 3     Vanilloid Receptor 13
OTRPC12 3     

External Ids:    HGNC: 127161   Entrez Gene: 74422   Ensembl: ENSG000001966897   OMIM: 6020765   UniProtKB: Q8NER13   

Export aliases for TRPV1 gene to outside databases

Previous GC identifers: GC17M003782 GC17M003419 GC17M003675 GC17M003415 GC17M003360 GC17M003469


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRPV1 Gene:
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively
activating sensory neurons that convey information about noxious stimuli to the central nervous system. The
protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is
structurally related to members of the TRP family of ion channels. This receptor is also activated by increases
in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in
vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described
for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for TRPV1 Gene:
TRPV1 (transient receptor potential cation channel, subfamily V, member 1) is a protein-coding gene. Diseases associated with TRPV1 include pulpitis, and burning mouth syndrome. GO annotations related to this gene include calcium channel activity and calmodulin binding. An important paralog of this gene is TRPV5.

UniProtKB/Swiss-Prot: TRPV1_HUMAN, Q8NER1
Function: Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical
and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive
neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second
messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Can be activated by
endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid
receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by
the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis
(By similarity). Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius,
exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild
extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic
conditions (pH <6) directly activate the channel

summary for TRPV1 Gene:
Vanilloids are a group of compounds, structurally related to capsaicin, thought to exert their actions via
vanilloid receptors. The vanilloid receptor family (TRPV) is a subgroup of the transient receptor potential
(TRP) superfamily of ion channels, and six members (TRPV1-6) have so far been identified. The six vanilloid
receptor members have been divided into four groups on the basis of structure and function: TRPV1/2, TRPV3,
TRPV4 and TRPV5/6. TRPV1-4 are thermosensitive, non-selective cation channels that exist as tetrameric
complexes. They are activated by a range of stimuli including heat, protons, lipids and changes in
osmolarity or pressure. TRPV5-6 are calcium selective channels that are involved in the absorption and
reabsorption of calcium across intestinal and renal epithelia. It has been proposed that cannabinoids are
endogenous ligands for vanilloid receptors. Furthermore, adenosine has been shown to be an endogenous TRPV1
ligand and TRPV4 is activated by anandamide and arachidonic acid.

Gene Wiki entry for TRPV1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRPV1 gene promoter:
         Sp1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TRPV1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRPV1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.2   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13.3

TRPV1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRPV1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M003471:  view genomic region     (about GC identifiers)

Start:
3,468,738 bp from pter      End:
3,512,705 bp from pter
Size:
43,968 bases      Orientation:
minus strand

1 alternative location:
Chr17- 3,468,738-3,539,543     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TRPV1_HUMAN, Q8NER1 (See protein sequence)
Recommended Name: Transient receptor potential cation channel subfamily V member 1  
Size: 839 amino acids; 94956 Da
Subunit: Homotetramer. Interacts with CALM, PRKCM and CSK. Interacts with PRKCG and NTRK1, probably by forming a
trimeric complex. Interacts with PIRT (By similarity). Interacts with TRPV3 and may also form a heteromeric
channel with TRPV3
Miscellaneous: Responses evoked by low pH and heat, and capsaicin can be antagonized by capsazepine
Sequence caution: Sequence=AAG43467.1; Type=Frameshift; Positions=498;
Secondary accessions: A2RUA9 Q9H0G9 Q9H303 Q9H304 Q9NQ74 Q9NY22

Explore the universe of human proteins at neXtProt for TRPV1: NX_Q8NER1

Explore proteomics data for TRPV1 at MOPED

Post-translational modifications: 

  • Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites, probably including Ser-117
    as a major phosphorylation site. Phoshphorylation by CAMKII seems to regulate binding to vanilloids.
    Phosphorylated and modulated by PRKCE, PRKCM and probably PRKCZ. Dephosphorylation by calcineurin seems to lead
    to receptor desensitization and phosphorylation by CAMKII recovers activity (By similarity)1
  • Glycosylation2 at Asn604
  • Modification sites at PhosphoSitePlus

  • See TRPV1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_061197.4  NP_542435.2  NP_542436.2  NP_542437.2  

    ENSEMBL proteins: 
     ENSP00000382661   ENSP00000461007   ENSP00000382659   ENSP00000409627   ENSP00000459042  
     ENSP00000311692   ENSP00000174621  
    Reactome Protein details: Q8NER1

    TRPV1 Human Recombinant Protein Products:

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    Novus Biologicals TRPV1 Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRPV1

     
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    antibodies-online proteins for TRPV1 (2 products) 

     
    antibodies-online peptides for TRPV1

    TRPV1 Antibody Products:

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    antibodies-online antibodies for TRPV1 (128 products) 

    TRPV1 Assay Products:

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    Cloud-Clone Corp. ELISAs for TRPV1
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    antibodies-online kits for TRPV1 (23 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TRP: Voltage-gated ion channels / Transient receptor potential cation channels
    ANKRD: Ankyrin repeat domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: TRPV1
    Transient Receptor Potential channels

    Selected InterPro protein domains (see all 6):
     IPR024863 TRPV1_channel
     IPR024862 TRPV
     IPR008347 TRPV1-4_channel
     IPR004729 TRP_channel
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry Q8NER1

    ProtoNet protein and cluster: Q8NER1

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: TRPV1_HUMAN, Q8NER1
    Domain: The association domain (AD) is necessary for self-association (By similarity)
    Similarity: Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV1 sub-subfamily
    Similarity: Contains 6 ANK repeats


    Find genes that share domains with TRPV1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRPV1_HUMAN, Q8NER1
    Function: Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical
    and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive
    neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second
    messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Can be activated by
    endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid
    receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by
    the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis
    (By similarity). Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius,
    exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild
    extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic
    conditions (pH <6) directly activate the channel
    Enzyme regulation: Channel activity is activated via the interaction with PIRT and phosphatidylinositol
    4,5-bisphosphate (PIP2). Both PIRT and PIP2 are required to activate channel activity (By similarity). The
    channel is sensitized by ATP binding. Repeated stimulation with capsaicin gives rise to progressively smaller
    responses, due to desensitization. This desensitization is triggered by the influx of calcium ions and is
    inhibited by elevated ATP levels. Ca(2+) and CALM displace ATP from its binding site and trigger a conformation
    change that leads to a closed, desensitized channel. Intracellular PIP2 inhibits desensitization. The double-knot
    toxin (DkTx) from the Chinese earth tiger tarantula activates the channel and traps it in an open conformation
    (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ISS--
    GO:0005216ion channel activity ----
    GO:0005231excitatory extracellular ligand-gated ion channel activity ISS--
    GO:0005262calcium channel activity TAS9349813
    GO:0005515protein binding ----
         
    Find genes that share ontologies with TRPV1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TRPV1:
     Increased Salmonella enterica  

         14 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Trpv1):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  growth/size/body 
     homeostasis/metabolism  immune system  integument  liver/biliary system  nervous system 
     no phenotypic analysis  renal/urinary system  taste/olfaction  tumorigenesis 

    Find genes that share phenotypes with TRPV1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TRPV1: Trpv1tm1Jul Trpv1tm1Jbd

       genOway: Develop your customized and physiologically relevant rodent model for TRPV1

    miRNA
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    miRTarBase miRNAs that target TRPV1:
    hsa-let-7e-5p (MIRT051594), hsa-mir-192-5p (MIRT026638), hsa-mir-215-5p (MIRT024445)

    Block miRNA regulation of human, mouse, rat TRPV1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate TRPV1:
    hsa-miR-188-3p hsa-miR-3120-3p hsa-miR-375 hsa-miR-1286
    SwitchGear 3'UTR luciferase reporter plasmidTRPV1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 4): TRPV1 (NM_080704)
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    eBioscience FlowRNA Probe Sets ( VA1-10885 VA1-12778) for TRPV1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRPV1_HUMAN, Q8NER1: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (By
    similarity). Cell projection, dendritic spine membrane; Multi-pass membrane protein (By similarity). Cell
    membrane; Multi-pass membrane protein. Note=Mostly, but not exclusively expressed in postsynaptic dendritic
    spines (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton2
    cytosol2
    extracellular2
    nucleus2
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9349813
    GO:0016021integral component of membrane IDA123456
    GO:0030054cell junction IEA--
    GO:0031226intrinsic component of plasma membrane ISS--

    Find genes that share ontologies with TRPV1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TRPV1 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58
    2CREB Pathway
    Intracellular Calcium Signaling0.50
    3Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    4Ca-dependent events
    Neurophysiological process PGE2 induced pain processing0.38
    5Development Endothelin 1 EDNRA signaling
    Inflammatory mediator regulation of TRP channels0.37


    Find genes that share SuperPaths with TRPV1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TRPV1
        Intracellular Calcium Signaling

    1 GeneGo (Thomson Reuters) Pathway for TRPV1
        Neurophysiological process PGE2-induced pain processing

    2 BioSystems Pathways for TRPV1
        Trk receptor signaling mediated by PI3K and PLC-gamma
    Trk receptor signaling mediated by the MAPK pathway

    1 Reactome Pathway for TRPV1
        TRP channels


    2 Kegg Pathways  (Kegg details for TRPV1):
        Neuroactive ligand-receptor interaction
    Inflammatory mediator regulation of TRP channels

        Pathway & Disease-focused RT2 Profiler PCR Array including TRPV1: 
              Neuronal Ion Channels in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TRPV1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for TRPV1 (Q8NER13 ENSP000001746214) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=2 STRING: ENSP00000349467
    CALM2P621583I2D: score=2 
    CALM3P621583I2D: score=2 
    SYT9Q86SS63, ENSP000003244194I2D: score=2 STRING: ENSP00000324419
    OS9Q134383, ENSP000003181654I2D: score=1 STRING: ENSP00000318165
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS9349813
    GO:0006811ion transport ----
    GO:0007166cell surface receptor signaling pathway TAS9349813
    GO:0007635chemosensory behavior TAS9349813
    GO:0034220ion transmembrane transport TAS--

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for TRPV1
      Browse compounds at ApexBio 

    Compounds for TRPV1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    HC 067047Potent and selective TRPV4 antagonist[883031-03-6]
    5'-Iodoresiniferatoxin Potent, silent TRPV1 antagonist [535974-91-5]
    CapsazepineVanilloid receptor antagonist. Also activator of ENaCdelta[138977-28-3]
    AMG 9810 Potent and selective, competitive antagonist of TRPV1 [545395-94-6]
    AnandamideEndogenous CB receptor agonist[94421-68-8]

    1 HMDB Compound for TRPV1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    3 DrugBank Compounds for TRPV1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alpha-Linolenic Acid(9Z,12Z,15Z)-Octadecatrienoic acid (see all 5)463-40-1target--17139284 17016423
    Aspartame1-Methyl N-L-alpha-aspartyl-L-phenylalanate (see all 17)22839-47-0targetinducer17567713
    IcosapentEicosapentaenoic acid (see all 4)10417-94-4targetinducer17038422

    Selected IUPHAR Ligands for TRPV1 (TRPV1) (see all 34)    About this table
    LigandTypeActionAffinityPubmed IDs
    AMG517
    Channel blockerNone9--
    [3H]A778317
    NoneNone8.5--
    SB705498
    Channel blockerNone8.2 - 8.5--
    AMG628
    Channel blockerNone8.4--
    5'-iodoresiniferatoxin
    Channel blockerNone8.4--
    A425619
    Channel blockerNone8.3--
    A778317
    Channel blockerNone8.3--
    BCTC
    Channel blockerNone7.5 - 8.2--
    6-iodo-nordihydrocapsaicin
    Channel blockerNone8--
    JYL1421
    Channel blockerNone8--

    Selected Novoseek inferred chemical compound relationships for TRPV1 gene (see all 58)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    capsaicin 96.1 754 20145248 (7), 11166956 (6), 14523239 (6), 10887936 (5) (see all 99)
    capsazepine 95.3 147 12721338 (5), 20096813 (4), 11226139 (3), 14960593 (3) (see all 76)
    resiniferatoxin 93.8 102 14637384 (4), 14996838 (4), 12522087 (3), 15049988 (3) (see all 38)
    ppahv 89.9 17 14960593 (5), 11226139 (1), 11166956 (1), 14996838 (1) (see all 6)
    n-oleoyl dopamine 87.5 11 15135917 (1), 19879868 (1), 15289293 (1), 14996838 (1) (see all 5)
    iodoresiniferatoxin 87.4 24 12642400 (5), 14992587 (1), 16982866 (1), 12205192 (1) (see all 8)
    anandamide 86.8 177 12861385 (3), 15453094 (3), 12823468 (3), 11278420 (2) (see all 35)
    olvanil 73.8 4 16394182 (2), 17244257 (1), 17442052 (1)
    ruthenium 73.7 23 11226139 (1), 15155534 (1), 15681035 (1), 17508360 (1) (see all 15)
    piperine 62.2 11 15685214 (5), 16043235 (2), 20460725 (2), 20381363 (1)



    Find genes that share compounds with TRPV1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRPV1 gene (4 alternative transcripts): 
    NM_018727.5  NM_080704.3  NM_080705.3  NM_080706.3  

    Unigene Cluster for TRPV1:

    Transient receptor potential cation channel, subfamily V, member 1
    Hs.655380  [show with all ESTs]
    Unigene Representative Sequence: NM_080706
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399759(uc010vro.2 uc010vrp.2 uc010vrs.2) ENST00000571088(uc010vrt.2)
    ENST00000399756(uc010vrr.2) ENST00000425167 ENST00000574085 ENST00000576351
    ENST00000310522 ENST00000570742 ENST00000174621(uc010vrq.2)
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    4 qRT-PCR Assays for microRNAs that regulate TRPV1:
    hsa-miR-188-3p hsa-miR-3120-3p hsa-miR-375 hsa-miR-1286
    SwitchGear 3'UTR luciferase reporter plasmidTRPV1 3' UTR sequence
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    Additional mRNA sequence: 

    AF196175.1 AF196176.1 AF235160.1 AJ272063.2 AJ277028.1 AL136801.1 AY131289.1 AY986821.1 
    BC132820.1 BC136633.1 DQ177332.1 DQ177333.1 DQ898279.1 

    8 DOTS entries:

    DT.91669749  DT.95248568  DT.91669751  DT.95152419  DT.309836  DT.97830252  DT.97835330  DT.40201459 

    Selected AceView cDNA sequences (see all 121):

    AF163573 BM704676 CA307823 CK300648 AI245655 BM676314 AA325795 AA331298 
    BX096339 NM_013276 BP346171 BQ676342 AA700014 BQ959791 AA411042 BM014650 
    AA410918 CB044884 BQ187326 AJ277028 AJ272063 AF196176 AI521215 CA314226 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TRPV1 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c · 17d
    SP1:        -                                               -                             -                                                               
    SP2:                                                                                      -                                                               
    SP3:                                                        -                             -                                                               
    SP4:                                                        -                             -                                                               
    SP5:                                                        -     -                       -                                                               


    ECgene alternative splicing isoforms for TRPV1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    TRPV1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTCCACTCC
    TRPV1 Expression
    About this image


    TRPV1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical Veins
    TRPV1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRPV1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655380

    UniProtKB/Swiss-Prot: TRPV1_HUMAN, Q8NER1
    Tissue specificity: Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin,
    expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner
    root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory
    portion of eccrine sweat glands (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Array including TRPV1: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TRPV1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trpv11 , 5 transient receptor potential cation channel, subfamily more1, 5 85.76(n)1
    86.99(a)1
      11 (45.25 cM)5
    1930341  NM_001001445.11  NP_001001445.11 
     732342925 
    chicken
    (Gallus gallus)
    Aves TRPV11 transient receptor potential cation channel, subfamily more 69.06(n)
    70.06(a)
      395259  NM_204572.1  NP_989903.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    70(a)
    1 → many
    GL345059.1(1423-11828)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia trpv11 transient receptor potential cation channel subfamily more 64.47(n)
    64.17(a)
      100487208  NM_001256592.1  NP_001243521.1 
    zebrafish
    (Danio rerio)
    Actinopterygii trpv11 transient receptor potential cation channel, subfamily more 59.76(n)
    52.19(a)
      561195  NM_001126399.1  NP_001119871.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nan6
    iav6
    inactive
    19(a)
    14(a)
    many ↔ many
    many ↔ many
    3L(14179349-14182748)
    X(6708151-6712189)
    worm
    (Caenorhabditis elegans)
    Secernentea osm-93 olfacory channel 27(a)   IV(3551152-3557432)   --


    ENSEMBL Gene Tree for TRPV1 (if available)
    TreeFam Gene Tree for TRPV1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRPV1 gene
    TRPV52  TRPV62  TRPV32  TRPV22  TRPV42  
    6 SIMAP similar genes for TRPV1 using alignment to 9 protein entries:     TRPV1_HUMAN (see all proteins):
    FLJ00078    TRPV2    TRPV4    TRPV6    TRPV3    ECAC2

    Find genes that share paralogs with TRPV1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRPV1 (see all 1752)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs106095601,2
    C--3360317(+) acaca-/C/CA  
            
    aacat
    4 -- ds50011NA 2
    rs719070511,2
    C--3367676(+) GTGCCTCAT/-  
            
    TCATT
    4 -- int11Minor allele frequency- -:0.50CSA 2
    rs24568551,2
    C--3368531(+) CCCCCC/ACCACC 4 -- int11Minor allele frequency- A:0.00NA 2
    rs2022456621,2
    --3368531(+) CCCCC-/ACCACC 4 -- int10--------
    rs2017031301,2
    C--3368869(+) CCTGCA/GGCAGG 8 R C mis10--------
    rs1507792491,2
    C--3373347(+) TAAAC-/AAAT  
            
    AAATA
    4 -- int10--------
    rs352062271,2
    C--3374965(+) TGGGG-/AAGCTC 4 -- int11Minor allele frequency- A:0.00NA 2
    rs2006743301,2
    C--3374965(+) TGGGGA/GAGCTC 4 -- int10--------
    rs1492083911,2
    --3457257(+) ACCATC/GGGGAG 4 -- ds50010--------
    rs620698771,2
    C--3457274(+) ACCATC/GGGGAG 4 -- ds50011Minor allele frequency- G:0.00NA 2

    HapMap Linkage Disequilibrium report for TRPV1 (3468738 - 3512705 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TRPV1 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715530CNV Deletion23290073
    esv2662762CNV Deletion23128226
    esv2662311CNV Deletion23128226
    esv2665638CNV Deletion23128226
    esv2639824CNV Insertion19546169
    nsv907568CNV Loss21882294
    dgv358n27CNV Loss19166990
    dgv3042n71CNV Loss21882294
    nsv907553CNV Loss21882294
    nsv907565CNV Loss21882294

    Human Gene Mutation Database (HGMD): TRPV1
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 602076    OMIM disorders: --

    8 diseases for TRPV1:    
    About MalaCards
    pulpitis    burning mouth syndrome    dentin sensitivity    dyspepsia
    bladder disease    somatoform disorder    autoimmune encephalitis    polycystic liver disease

    5 diseases from the University of Copenhagen DISEASES database for TRPV1:
    Pain agnosia     Irritable bowel syndrome     Migraine     Neuropathy
    Cystitis

    Find genes that share disorders with TRPV1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TRPV1 gene (see all 34)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperalgesia 82 79 15659614 (5), 17978048 (4), 15128844 (4), 18509045 (3) (see all 36)
    bladder diseases 61.7 4 17560087 (1)
    inflammation 52.3 75 17005903 (4), 16394182 (2), 17539893 (2), 11259480 (2) (see all 45)
    functional dyspepsia 48.9 1 17195120 (1)
    diabetic neuropathies 39.9 5 17521436 (3), 15128291 (1)
    acidosis 38.2 4 14644014 (1), 17323179 (1), 14699077 (1), 10859346 (1)
    detrusor hyperreflexia 30.7 1 15579007 (1)
    pulpitis 29 3 14520770 (1), 16106719 (1)
    neuroma 20.8 1 17109831 (2), 19150372 (1)
    motility disorder 13.5 2 15051629 (1)

    Genetic Association Database (GAD): TRPV1
    Human Genome Epidemiology (HuGE) Navigator: TRPV1 (12 documents)

    Export disorders for TRPV1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRPV1 gene, integrated from 10 sources (see all 597):
    (articles sorted by number of sources associating them with TRPV1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Pharmacological differences between human and rat vanilloid receptor 1 (VR1). (PubMed id 11226139)1, 2, 9 McIntyre P.... James I. (Br. J. Pharmacol. 2001)
    2. Molecular determinants of vanilloid sensitivity in TRPV1. (PubMed id 14996838)1, 2, 9 Gavva N.R....Treanor J.J. (J. Biol. Chem. 2004)
    3. Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures. (PubMed id 14987252)1, 2, 9 Staender S.... Steinhoff M. (Exp. Dermatol. 2004)
    4. The tissue distribution and functional characterization of human VR1. (PubMed id 11243859)1, 2, 9 Cortright D.N....White G. (Biochem. Biophys. Res. Commun. 2001)
    5. Polymorphisms in gene encoding TRPV1-receptor involved in pain perception are unrelated to chronic pancreatitis. (PubMed id 20034385)1, 4, 9 van Esch A.A....Drenth J.P. (BMC Gastroenterol 2009)
    6. Cloning and functional expression of a human orthologue of rat vanilloid receptor-1. (PubMed id 11050376)1, 2, 9 Hayes P.... Davis J.B. (Pain 2000)
    7. The capsaicin receptor: a heat-activated ion channel in the pain pathway. (PubMed id 9349813)1, 3, 9 Caterina M.J....Julius D. (Nature 1997)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    9. Loss of function of transient receptor potential vanilloid 1 (TRPV1) genetic variant is associated with lower risk of active childhood asthma. (PubMed id 20639579)1, 4 Cantero-Recasens G....Valverde M.A. (J. Biol. Chem. 2010)
    10. Homozygous TRPV1 315C influences the susceptibility to functional dyspepsia. (PubMed id 19770677)1, 4 Tahara T....Arisawa T. (J. Clin. Gastroenterol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7442 HGNC: 12716 AceView: CARKL Ensembl:ENSG00000196689 euGenes: HUgn7442
    ECgene: TRPV1 Kegg: 7442 H-InvDB: TRPV1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TRPV1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRPV1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TRPV1 gene:
    Search GeneIP for patents involving TRPV1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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