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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TRPV1 Gene

protein-coding GIFtS: 66
GCID: GC17M003469

transient receptor potential cation channel, subfamily V,...

(Previous name: vanilloid receptor subtype 1 )
(Previous symbol: VR1)

Explore 50 diseases affiliated with
TRPV1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transient Receptor Potential Cation Channel, Subfamily V, Member 1¹ ²		Transient Receptor Potential Cation Channel Subfamily V Member 1²
VR1¹ ² ³ ⁵		Transient Receptor Potential Vanilloid 1a²
Vanilloid Receptor Subtype 1¹ ²		Transient Receptor Potential Vanilloid 1b²
Capsaicin Receptor² ³		TrpV1³
Osm-9-Like TRP Channel 1² ³		Vanilloid Receptor 1³
OTRPC1² ³

External Ids:	HGNC: 12716¹	Entrez Gene: 7442²	Ensembl: ENSG00000196689⁷	OMIM: 602076⁵	UniProtKB: Q8NER1³

Export aliases for TRPV1 gene to outside databases

Previous GC identifers: GC17M003782 GC17M003419 GC17M003675 GC17M003415 GC17M003360

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRPV1:

Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively

activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein

encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to

members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious

range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants

encoding the same protein, but with different 5' UTR sequence, have been described for this gene. (provided by RefSeq,

Jul 2008)

UniProtKB/Swiss-Prot: TRPV1_HUMAN, Q8NER1

Function: Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical

and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive

neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol

second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Acts as

ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression

(TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA

receptors endocytosis (By similarity)

summary for TRPV1:

Vanilloids are a group of compounds, structurally related to capsaicin, thought to exert their actions via

vanilloid receptors. The vanilloid receptor family (TRPV) is a subgroup of the transient receptor potential

(TRP) superfamily of ion channels, and six members (TRPV1-6) have so far been identified. The six vanilloid

receptor members have been divided into four groups on the basis of structure and function: TRPV1/2, TRPV3,

TRPV4 and TRPV5/6. TRPV1-4 are thermosensitive, non-selective cation channels that exist as tetrameric

complexes. They are activated by a range of stimuli including heat, protons, lipids and changes in

osmolarity or pressure. TRPV5-6 are calcium selective channels that are involved in the absorption and

reabsorption of calcium across intestinal and renal epithelia. It has been proposed that cannabinoids are

endogenous ligands for vanilloid receptors. Furthermore, adenosine has been shown to be an endogenous TRPV1

ligand and TRPV4 is activated by anandamide and arachidonic acid.

Gene Wiki entry for TRPV1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010718.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TRPV1 gene promoter:
Sp1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for TRPV1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRPV1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.2 Ensembl cytogenetic band: 17p13.2 HGNC cytogenetic band: 17p13.3

TRPV1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRPV1 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M003469: view genomic region (about GC identifiers)

Start:	3,468,738 bp from pter	End:	3,512,705 bp from pter
Size:	43,968 bases	Orientation:	minus strand

1 alternative location:

Chr17- 3,468,738-3,539,543

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TRPV1_HUMAN, Q8NER1 (See protein sequence)

Recommended Name: Transient receptor potential cation channel subfamily V member 1

Size: 839 amino acids; 94956 Da

Subunit: Self-associates. Probably homotetramer. May also form a heteromeric channel with TRPV3. Interacts with

calmodulin, PIRT, PRKCM and CSK. Interacts with PRKCG and NTRK1, probably by forming a trimeric complex (By

similarity)

Subcellular location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (By similarity).

Cell projection, dendritic spine membrane; Multi-pass membrane protein (By similarity)

Miscellaneous: Responses evoked by low pH and heat, and capsaicin can be antagonized by capsazepine

Sequence caution: Sequence=AAG43467.1; Type=Frameshift; Positions=498;

Secondary accessions: A2RUA9 Q9H0G9 Q9H303 Q9H304 Q9NQ74 Q9NY22

Explore the universe of human proteins at neXtProt for TRPV1: NX_Q8NER1

Post-translational modifications:

Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites, probably including Ser-117 as a

major phosphorylation site. Phoshphorylation by CAMKII seems to regulate binding to vanilloids. Phosphorylated and

modulated by PRKCE, PRKCM and probably PRKCZ. Dephosphorylation by calcineurin seems to lead to receptor

desensitization and phosphorylation by CAMKII recovers activity (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8NER1

TRPV1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_061197.4 NP_542435.2 NP_542436.2 NP_542437.2

ENSEMBL proteins:

ENSP00000382661 ENSP00000461007 ENSP00000382659 ENSP00000409627 ENSP00000459042

ENSP00000311692 ENSP00000174621

Human Recombinant Protein Products for TRPV1:

	EMD Millipore Purified and/or Recombinant TRPV1 Protein
	Browse R&D Systems for human recombinant proteins
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	GenScript Custom Purified and Recombinant Proteins Services for TRPV1
	Novus Biologicals TRPV1 Proteins Novus Biologicals TRPV1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TRPV1

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral to plasma membrane	TAS	9349813
GO:0016021	integral to membrane	IDA	123456
GO:0030054	cell junction	IEA	--
GO:0032591	dendritic spine membrane	IEA	--
GO:0045211	postsynaptic membrane	ISS	--

TRPV1 for ontologies About GeneDecksing

TRPV1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of TRPV1
	R&D Systems Antibodies for TRPV1 (Vanilloid R1/TRPV1)
	OriGene Antibodies: TRPV1 OriGene Custom Antibody Services for TRPV1
	GenScript Custom Superior Antibodies Services for TRPV1
	Novus Biologicals TRPV1 Antibodies
	Abcam antibodies for TRPV1
	Uscn Antibodies for TRPV1
	ThermoFisher Antibody for TRPV1

Assay Products for TRPV1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TRPV1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TRPV1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TRPV1 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR024863 TRPV1_channel

IPR024862 TRPV_channel

IPR008347 TRPV1-4_channel

IPR020683 Ankyrin_rpt-contain_dom

IPR004729 TRP_channel

Graphical View of Domain Structure for InterPro Entry Q8NER1

ProtoNet protein and cluster: Q8NER1

1 Blocks protein family: IPB002110 Ankyrin repeat signature

UniProtKB/Swiss-Prot: TRPV1_HUMAN, Q8NER1

Domain: The association domain (AD) is necessary for self-association (By similarity)

Similarity: Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV1 sub-subfamily

Similarity: Contains 6 ANK repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TRPV1_HUMAN, Q8NER1

Function: Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical

and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive

neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol

second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Acts as

ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression

(TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA

receptors endocytosis (By similarity)

Enzyme regulation: Channel activity is activated via the interaction with PIRT and phosphatidylinositol

4,5-bisphosphate (PIP2). Both PIRT and PIP2 are required to activate channel activity (By similarity)

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005216	ion channel activity	--	--
GO:0005262	calcium channel activity	IEA	--
GO:0005516	calmodulin binding	IEA	--
GO:0005524	ATP binding	IEA	--

TRPV1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for TRPV1:

Increased Salmonella enterica

14 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Trpv1):

adipose tissue	behavior/neurological	cardiovascular system	cellular	growth/size
homeostasis/metabolism	immune system	integument	liver/biliary system	nervous system
no phenotypic analysis	renal/urinary system	taste/olfaction	tumorigenesis

TRPV1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for TRPV1: Trpv1^tm1Jul Trpv1^tm1Jbd

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TRPV1

miRNA Products:		OriGene 3'-UTR Clone (see all 4): TRPV1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRPV1
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate TRPV1:
		hsa-miR-188-3p hsa-miR-3120-3p hsa-miR-375 hsa-miR-1286
		SwitchGear 3'UTR luciferase reporter plasmid: TRPV1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRPV1 (see all 7) OriGene shRNA RFP: TRPV1 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRPV1
		Sirion Biotech Custom design and validation of potent shRNA sequences against TRPV1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for TRPV1
			Sirion Biotech Customized adenovirus for overexpression of TRPV1 Sirion Biotech Customized adenovirus for potent knockdown of TRPV1

Clone Products:		EMD Millipore Clones for the Expression of TRPV1
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRPV1 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRPV1 (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): TRPV1 (NM_080704)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRPV1
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TRPV1
		Search LifeMap BioReagents cell lines for TRPV1
		Sirion Biotech Customized stable knockdown cell line services for TRPV1 Sirion Biotech Customized inducible knockdown cell line services for TRPV1 Sirion Biotech Customized stable overexpressing cell line services for TRPV1 Sirion Biotech Customized inducible overexpressing cell line services for TRPV1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPV1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PKA activation in glucagon signalling

Neurophysiological process_PGE2-induced pain processing

0.44

Neurophysiological process PGE2-induced pain processing

0.44

Calcium channels

Calcium channels

1.00

Sodium channels and transporters: inward current

Sodium channels and transporters: inward current

1.00

Trk receptor signaling mediated by the MAPK pathway

Trk receptor signaling mediated by the MAPK pathway

1.00

Trk receptor signaling mediated by PI3K and PLC-gamma

Trk receptor signaling mediated by PI3K and PLC-gamma

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for TRPV1

	Neurophysiological process PGE2-induced pain processing
	Sodium channels and transporters- inward current
	Calcium channels

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TRPV1

Intracellular Calcium Signaling

1 GeneGo (Thomson Reuters) Pathway for TRPV1

Neurophysiological process PGE2-induced pain processing

2 BioSystems Pathways for TRPV1

	Trk receptor signaling mediated by PI3K and PLC-gamma
	Trk receptor signaling mediated by the MAPK pathway

1 Kegg Pathway (Kegg details for TRPV1):

Neuroactive ligand-receptor interaction

TRPV1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TRPV1

STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

5/18 Interacting proteins for TRPV1 (Q8NER1³ ENSP00000174621⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 18)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CALM1	P62158³, ENSP00000349467⁴	I2D: score=2 STRING: ENSP00000349467
CALM2	P62158³	I2D: score=2
CALM3	P62158³	I2D: score=2
SYT9	Q86SS6³, ENSP00000324419⁴	I2D: score=2 STRING: ENSP00000324419
OS9	Q13438³, ENSP00000318165⁴	I2D: score=1 STRING: ENSP00000318165

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	TAS	9349813
GO:0007166	cell surface receptor signaling pathway	TAS	9349813
GO:0007635	chemosensory behavior	TAS	9349813
GO:0050955	thermoception	IDA	123456
GO:0070588	calcium ion transmembrane transport	--	--

TRPV1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TRPV1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for TRPV1

Compounds for TRPV1 available from Tocris Bioscience About this table

Compound	Action	CAS #
SB 366791	Potent, selective, competitive TRPV1 (VR1) antagonist	[472981-92-3]
A 784168	Potent and selective TRPV1 antagonist	[824982-41-4]
5'-Iodoresiniferatoxin	Potent, silent TRPV1 antagonist	--
Capsazepine	Vanilloid receptor antagonist. Also activator of ENaCdelta	[138977-28-3]
AMG 9810	Potent and selective, competitive antagonist of TRPV1	[545395-94-6]

1 HMDB Compound for TRPV1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

3 DrugBank Compounds for TRPV1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Alpha-Linolenic Acid	(9Z,12Z,15Z)-Octadecatrienoic acid (see all 5)	463-40-1	target	--	17139284 17016423
Aspartame	1-Methyl N-L-alpha-aspartyl-L-phenylalanate (see all 17)	22839-47-0	target	inducer	17567713
Icosapent	Eicosapentaenoic acid (see all 4)	10417-94-4	target	inducer	17038422

10/58 Novoseek chemical compound relationships for TRPV1 gene (see all 58) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
capsaicin	96.1	754	20145248 (7), 11166956 (6), 14523239 (6), 10887936 (5) (see all 99)
capsazepine	95.3	147	12721338 (5), 20096813 (4), 11226139 (3), 14960593 (3) (see all 76)
resiniferatoxin	93.8	102	14637384 (4), 14996838 (4), 12522087 (3), 15049988 (3) (see all 38)
ppahv	89.9	17	14960593 (5), 11226139 (1), 11166956 (1), 14996838 (1) (see all 6)
n-oleoyl dopamine	87.5	11	15135917 (1), 19879868 (1), 15289293 (1), 14996838 (1) (see all 5)
iodoresiniferatoxin	87.4	24	12642400 (5), 14992587 (1), 16982866 (1), 12205192 (1) (see all 8)
anandamide	86.8	177	12861385 (3), 15453094 (3), 12823468 (3), 11278420 (2) (see all 35)
olvanil	73.8	4	16394182 (2), 17244257 (1), 17442052 (1)
ruthenium	73.7	23	11226139 (1), 15155534 (1), 15681035 (1), 17508360 (1) (see all 15)
piperine	62.2	11	15685214 (5), 16043235 (2), 20460725 (2), 20381363 (1)

Search CenterWatch for drugs/clinical trials and news about TRPV1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TRPV1 gene (4 alternative transcripts):

NM_018727.5 NM_080704.3 NM_080705.3 NM_080706.3

Unigene Cluster for TRPV1:

Transient receptor potential cation channel, subfamily V, member 1

Hs.655380 [show with all ESTs]

Unigene Representative Sequence: NM_080706

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000399759(uc010vro.2 uc010vrp.2 uc010vrs.2) ENST00000571088(uc010vrt.2)

ENST00000399756(uc010vrr.2) ENST00000425167 ENST00000574085 ENST00000576351

ENST00000310522 ENST00000570742 ENST00000174621(uc010vrq.2)

miRNA Products:		OriGene 3'-UTR Clone (see all 4): TRPV1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRPV1
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate TRPV1:
		hsa-miR-188-3p hsa-miR-3120-3p hsa-miR-375 hsa-miR-1286
		SwitchGear 3'UTR luciferase reporter plasmid: TRPV1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRPV1 (see all 7) OriGene shRNA RFP: TRPV1 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRPV1
		Sirion Biotech Custom design and validation of potent shRNA sequences against TRPV1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRPV1 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRPV1 (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): TRPV1 (NM_080704)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRPV1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPV1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRPV1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TRPV1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRPV1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRPV1

Additional cDNA sequence:

AF196175.1 AF196176.1 AF235160.1 AJ272063.2 AJ277028.1 AL136801.1 AY131289.1 AY986821.1

BC132820.1 BC136633.1 DQ177332.1 DQ177333.1 DQ898279.1

8 DOTS entries:

DT.91669749 DT.95248568 DT.91669751 DT.95152419 DT.309836 DT.97830252 DT.97835330 DT.40201459

24/121 AceView cDNA sequences (see all 121):

CK300648 AA411042 AF163573 BM676314 AJ277028 AA700014 AA410918 BQ187326

NM_013276 AA325795 BQ676342 BP346171 CB044884 CA307823 BQ959791 BM704676

AA331298 BX096339 AI245655 BM014650 BM832559 CD635937 AA553482 CD624690

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TRPV1 (see all 6) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14a	·	14b	^	15	^	16	^	17a	·	17b	·	17c	·	17d
SP1:			-																-										-
SP2:																													-
SP3:																			-										-
SP4:																			-										-
SP5:																			-		-								-

ECgene alternative splicing isoforms for TRPV1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRPV1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTCCACTCC

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TRPV1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Umbilical Cord

Umbilical Veins

Umbilical Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TRPV1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRPV1

SOURCE GeneReport for Unigene cluster: Hs.655380

UniProtKB/Swiss-Prot: TRPV1_HUMAN, Q8NER1

Tissue specificity: Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed

in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and

the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine

sweat glands (at protein level)

SABiosciences Expression via Pathway-Focused PCR Array including TRPV1:

Neuronal Ion Channels in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for TRPV1 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TRPV1¹	transient receptor potential cation channel, subfamily more	69.06(n) 70.06(a)		395259 NM_204572.1 NP_989903.1
lizard (Anolis carolinensis)	Reptilia	TRPV1⁶	--	68(a)	1 → many	GL345059.1(1423-11828)
zebrafish (Danio rerio)	Actinopterygii	trpv1¹	transient receptor potential cation channel subfamily more	59.61(n) 52.05(a)		561195 NM_001126399.1 NP_001119871.1
fruit fly (Drosophila melanogaster)	Insecta	nan⁶ iav⁶	inactive	19(a) 13(a)	many ↔ many many ↔ many	3L(14179349-14182748) X(6708151-6712189)
worm (Caenorhabditis elegans)	Secernentea	osm-9³	olfacory channel	27(a)		IV(3551152-3557432) --

ENSEMBL Gene Tree for TRPV1 (if available)
TreeFam Gene Tree for TRPV1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for TRPV1 gene

TRPV5² TRPV6² TRPV2² TRPV3² TRPV4²

6 SIMAP similar genes for TRPV1 using alignment to 9 protein entries: TRPV1_HUMAN (see all proteins):

FLJ00078 TRPV2 TRPV4 TRPV6 TRPV3 ECAC2

TRPV1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs379156^1,2	C,H	--	3360188(-)	`AAAAAG/ACTTAC`	4	--	ds500¹		5		NS EA NA	354
rs191503387^1,2	C	--	3360449(+)	`CGATAC/TATATG`	4	--	ut3¹		0	--	--	--	--
rs55687717^1,2	C	--	3360474(+)	`TATTTC/GAGGAT`	4	--	ut3¹		0	--	--	--	--
rs182823290^1,2	C	--	3360515(+)	`ATTGCA/GGAGAA`	4	--	ut3¹		0	--	--	--	--
rs56300710^1,2	C	--	3360673(+)	`CTGCTC/GCAACA`	4	--	ut3¹		0	--	--	--	--
rs72817814^1,2	C	--	3360779(+)	`AGCAAG/TCACGG`	4	--	ut3¹		0	--	--	--	--
rs148046190^1,2	C	--	3360783(+)	`AGCACA/GGCACA`	4	--	ut3¹		0	--	--	--	--
rs188688197^1,2	C	--	3360805(+)	`CCTCTA/GCATTT`	4	--	ut3¹		0	--	--	--	--
rs58868916^1,2	C	--	3361332(+)	`CTATTT/AAAAAA`	4	--	ut3¹		1		WA	2
rs56381605^1,2	C	--	3361368(+)	`GGCACA/GTGCCT`	4	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TRPV1 (3468738 - 3512705 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for TRPV1
2 CNVs: 53542 49851
1 Indel: 102388
Human Gene Mutation Database (HGMD): TRPV1

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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TRPV1 for disorders           About GeneDecksing

OMIM gene information: 602076    OMIM disorders: --

20/50 diseases for TRPV1 (see all 50):    About MalaCards

gastroesophageal reflux disease sick building syndrome burning mouth syndrome lichen planus

oral lichen planus pulpitis allergic rhinitis dentin sensitivity

congestive heart failure somatoform disorder irritable bowel syndrome dyspepsia

insensitivity to pain diabetic neuropathy neuroma gastric ulcer

hearing loss atopic dermatitis rhinitis transitional cell carcinoma

5 diseases from the University of Copenhagen DISEASES database for TRPV1:

Pain agnosia Irritable bowel syndrome Migraine Cystitis

Neuropathy

10/34 Novoseek disease relationships for TRPV1 gene (see all 34) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hyperalgesia	82	79	15659614 (5), 17978048 (4), 15128844 (4), 18509045 (3) (see all 36)
bladder diseases	61.7	4	17560087 (1)
inflammation	52.3	75	17005903 (4), 16394182 (2), 17539893 (2), 11259480 (2) (see all 45)
functional dyspepsia	48.9	1	17195120 (1)
diabetic neuropathies	39.9	5	17521436 (3), 15128291 (1)
acidosis	38.2	4	14644014 (1), 17323179 (1), 14699077 (1), 10859346 (1)
detrusor hyperreflexia	30.7	1	15579007 (1)
pulpitis	29	3	14520770 (1), 16106719 (1)
neuroma	20.8	1	17109831 (2), 19150372 (1)
motility disorder	13.5	2	15051629 (1)

Human Genome Epidemiology (HuGE) Navigator: TRPV1 (12 documents)

Export disorders for TRPV1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TRPV1 gene, integrated from 9 sources (see all 572):
(articles sorted by number of sources associating them with TRPV1)

Utopia: connect your pdf to the dynamic
world of online information

Pharmacological differences between human and rat vanilloid receptor 1 (VR1). (PubMed id 11226139)^{1, 2, 9} McIntyre P.... James I. (2001)
Molecular determinants of vanilloid sensitivity in TRPV1. (PubMed id 14996838)^{1, 2, 9} Gavva N.R....Treanor J.J. (2004)
Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures. (PubMed id 14987252)^{1, 2, 9} Staender S.... Steinhoff M. (2004)
The tissue distribution and functional characterization of human VR1. (PubMed id 11243859)^{1, 2, 9} Cortright D.N....White G. (2001)
Cloning and functional expression of a human orthologue of rat vanilloid receptor-1. (PubMed id 11050376)^{1, 2, 9} Hayes P.... Davis J.B. (2000)
The capsaicin receptor: a heat-activated ion channel in the pain pathway. (PubMed id 9349813)^{1, 3, 9} Caterina M.J....Julius D. (1997)
Artificial sweeteners and salts producing a metallic taste sensation activate TRPV1 receptors. (PubMed id 17567713)^{1, 7} Riera C.E....le Coutre J. (2007)
International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. (PubMed id 16382100)^{1, 3} Clapham D.E....Schultz G. (2005)
TRPV3 is a temperature-sensitive vanilloid receptor-like protein. (PubMed id 12077606)^{1, 2} Smith G.D.... Davis J.B. (2002)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7442	HGNC: 12716	AceView: CARKL	Ensembl:ENSG00000196689	euGenes: HUgn7442
ECgene: TRPV1	Kegg: 7442	H-InvDB: TRPV1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TRPV1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TRPV1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TRPV1 gene:
Search GeneIP for patents involving TRPV1

GeneCards and IP:
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