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Aliases for TRPT1 Gene

Aliases for TRPT1 Gene

  • TRNA Phosphotransferase 1 2 3 5
  • TRNA Splicing 2 Phosphotransferase 1 2
  • EC 2.7.1.160 4

External Ids for TRPT1 Gene

Previous GeneCards Identifiers for TRPT1 Gene

  • GC00U911626
  • GC11M063748
  • GC11M063991
  • GC11M060319

Summaries for TRPT1 Gene

GeneCards Summary for TRPT1 Gene

TRPT1 (TRNA Phosphotransferase 1) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and tRNA 2-phosphotransferase activity.

UniProtKB/Swiss-Prot for TRPT1 Gene

  • Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2-phosphate from ligated tRNA to NAD to produce ADP-ribose 1-2 cyclic phosphate.

Gene Wiki entry for TRPT1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRPT1 Gene

Genomics for TRPT1 Gene

Regulatory Elements for TRPT1 Gene

Enhancers for TRPT1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRPT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRPT1 Gene

Chromosome:
11
Start:
64,223,799 bp from pter
End:
64,226,254 bp from pter
Size:
2,456 bases
Orientation:
Minus strand

Genomic View for TRPT1 Gene

Genes around TRPT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRPT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRPT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRPT1 Gene

Proteins for TRPT1 Gene

  • Protein details for TRPT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TN4-TRPT1_HUMAN
    Recommended name:
    tRNA 2-phosphotransferase 1
    Protein Accession:
    Q86TN4
    Secondary Accessions:
    • A8MU17
    • A8MYC9
    • F5H2B2
    • Q9BSB9

    Protein attributes for TRPT1 Gene

    Size:
    253 amino acids
    Molecular mass:
    27742 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRPT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRPT1 Gene

Proteomics data for TRPT1 Gene at MOPED

Post-translational modifications for TRPT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRPT1 Gene

Domains & Families for TRPT1 Gene

Protein Domains for TRPT1 Gene

Suggested Antigen Peptide Sequences for TRPT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86TN4

UniProtKB/Swiss-Prot:

TRPT1_HUMAN :
  • Belongs to the KptA/TPT1 family.
Family:
  • Belongs to the KptA/TPT1 family.
genes like me logo Genes that share domains with TRPT1: view

No data available for Gene Families for TRPT1 Gene

Function for TRPT1 Gene

Molecular function for TRPT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP ribose 1,2-phosphate + nicotinamide + H(2)O.
UniProtKB/Swiss-Prot Function:
Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2-phosphate from ligated tRNA to NAD to produce ADP-ribose 1-2 cyclic phosphate.

Enzyme Numbers (IUBMB) for TRPT1 Gene

genes like me logo Genes that share phenotypes with TRPT1: view

Animal Models for TRPT1 Gene

MGI Knock Outs for TRPT1:

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TRPT1 Gene

Localization for TRPT1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRPT1 Gene COMPARTMENTS Subcellular localization image for TRPT1 gene
Compartment Confidence
mitochondrion 3
cytosol 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRPT1 Gene

Pathways & Interactions for TRPT1 Gene

SuperPathways for TRPT1 Gene

No Data Available

Interacting Proteins for TRPT1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000378050%0d%0a9606.ENSP00000254730%0d%0a9606.ENSP00000313171%0d%0a
Selected Interacting proteins: Q86TN4-TRPT1_HUMAN ENSP00000378050 for TRPT1 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for TRPT1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRPT1 Gene

Drugs & Compounds for TRPT1 Gene

(2) Drugs for TRPT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Experimental Nutra 850,854
NAD Pharma Full agonist, Agonist 0

(2) Additional Compounds for TRPT1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP-ribose 2'-phosphate
  • 2'-Phosphoadenosine 5'-[3-(D-ribofuranosyl) dihydrogen diphosphate]
  • ADP-D-Ribose 2'-phosphate
  • ADPribose 2'-phosphate
26303-90-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with TRPT1: view

Transcripts for TRPT1 Gene

Unigene Clusters for TRPT1 Gene

TRNA phosphotransferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRPT1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: - - - -
SP6: - - -
SP7:
SP8: - - -
SP9: -
SP10:
SP11:

Relevant External Links for TRPT1 Gene

GeneLoc Exon Structure for
TRPT1
ECgene alternative splicing isoforms for
TRPT1

Expression for TRPT1 Gene

mRNA expression in normal human tissues for TRPT1 Gene

mRNA differential expression in normal tissues according to GTEx for TRPT1 Gene

This gene is overexpressed in Muscle - Skeletal (x4.3).

Protein differential expression in normal tissues from HIPED for TRPT1 Gene

This gene is overexpressed in Breast (29.3) and Lung (23.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRPT1 Gene



SOURCE GeneReport for Unigene cluster for TRPT1 Gene Hs.326586

mRNA Expression by UniProt/SwissProt for TRPT1 Gene

Q86TN4-TRPT1_HUMAN
Tissue specificity: Widely expressed. Weakly or not expressed in lung, spleen, small intestine and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with TRPT1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for TRPT1 Gene

Orthologs for TRPT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRPT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRPT1 35
  • 87.22 (n)
  • 84.19 (a)
TRPT1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRPT1 35
  • 87.22 (n)
  • 86.96 (a)
TRPT1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trpt1 35
  • 84.95 (n)
  • 83.87 (a)
Trpt1 16
Trpt1 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRPT1 35
  • 99.48 (n)
  • 99.61 (a)
TRPT1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trpt1 35
  • 84.75 (n)
  • 83 (a)
oppossum
(Monodelphis domestica)
Mammalia TRPT1 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRPT1 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRPT1 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trpt1 35
  • 59.36 (n)
  • 61.19 (a)
zebrafish
(Danio rerio)
Actinopterygii trpt1 35
  • 57.53 (n)
  • 56.73 (a)
trpt1 36
  • 53 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2923 35
fruit fly
(Drosophila melanogaster)
Insecta CG33057 35
  • 47.06 (n)
  • 39.22 (a)
CG33057 36
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TPT1 36
  • 33 (a)
OneToOne
TPT1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons emb1067 35
  • 48.13 (n)
  • 41.7 (a)
rice
(Oryza sativa)
Liliopsida Os06g0134050 35
  • 49 (n)
  • 40.55 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC2C4.12c 35
  • 48.64 (n)
  • 45.92 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
-- 36
  • 28 (a)
OneToMany
Species with no ortholog for TRPT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRPT1 Gene

ENSEMBL:
Gene Tree for TRPT1 (if available)
TreeFam:
Gene Tree for TRPT1 (if available)

Paralogs for TRPT1 Gene

No data available for Paralogs for TRPT1 Gene

Variants for TRPT1 Gene

Sequence variations from dbSNP and Humsavar for TRPT1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_030134 -
VAR_030135 -
VAR_030136 -

Structural Variations from Database of Genomic Variants (DGV) for TRPT1 Gene

Variant ID Type Subtype PubMed ID
dgv1156n71 CNV Loss 21882294
nsv469961 CNV Loss 18288195
dgv1163n71 CNV Loss 21882294
dgv1164n71 CNV Loss 21882294
dgv1165n71 CNV Loss 21882294
dgv1166n71 CNV Loss 21882294
nsv832186 CNV Loss 17160897
dgv1167n71 CNV Loss 21882294
esv992196 CNV Deletion 20482838

Variation tolerance for TRPT1 Gene

Residual Variation Intolerance Score: 72.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.29; 81.34% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TRPT1 Gene

Disorders for TRPT1 Gene

Relevant External Links for TRPT1

Genetic Association Database (GAD)
TRPT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRPT1

No disorders were found for TRPT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRPT1 Gene

Publications for TRPT1 Gene

  1. A human homolog of the yeast gene encoding tRNA 2'- phosphotransferase: cloning, characterization and complementation analysis. (PMID: 14504659) Hu Q.-D. … Li Y.-Y. (Cell. Mol. Life Sci. 2003) 2 3 4 67
  2. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  3. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L. … Cho J.H. (Nature 2012) 3
  4. Genome-wide association study of the child behavior checklist dysregulation profile. (PMID: 21784300) Mick E. … Faraone S.V. (J Am Acad Child Adolesc Psychiatry 2011) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for TRPT1 Gene

Sources for TRPT1 Gene

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