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Aliases for TRPT1 Gene

Aliases for TRPT1 Gene

  • TRNA Phosphotransferase 1 2 3 5
  • TRNA Splicing 2 Phosphotransferase 1 2
  • EC 2.7.1.160 4

External Ids for TRPT1 Gene

Previous GeneCards Identifiers for TRPT1 Gene

  • GC00U911626
  • GC11M063748
  • GC11M063991
  • GC11M060319

Summaries for TRPT1 Gene

GeneCards Summary for TRPT1 Gene

TRPT1 (TRNA Phosphotransferase 1) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and tRNA 2-phosphotransferase activity.

UniProtKB/Swiss-Prot for TRPT1 Gene

  • Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2-phosphate from ligated tRNA to NAD to produce ADP-ribose 1-2 cyclic phosphate.

Gene Wiki entry for TRPT1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRPT1 Gene

Genomics for TRPT1 Gene

Regulatory Elements for TRPT1 Gene

Enhancers for TRPT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G064180 1.2 Ensembl ENCODE 33.9 +44.7 44697 2.1 HDGF PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF2 ZNF48 SLC30A9 ZNF121 TRPT1 FERMT3 ENSG00000257086 PLCB3 ENSG00000256341 NAA40 CCDC88B PIR62169 STIP1
GH11G064224 1.1 ENCODE 34.1 +0.2 165 3.6 HDGF CREB3L1 ARNT AGO1 ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 TRPT1 TRMT112 ENSG00000256116 NUDT22
GH11G064205 1.4 ENCODE dbSUPER 25.8 +18.7 18659 4.4 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZFPL1 TRPT1 ENSG00000257086 PLCB3 TRMT112 GPR137 BAD KCNK4-TEX40 KCNK4 ENSG00000207024
GH11G064163 1.1 ENCODE 32.2 +60.8 60831 4.0 HDGF PKNOX1 FOXA2 CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 TRPT1 TRMT112 ENSG00000256481 ENSG00000256341 NAA40 CCDC88B ENSG00000256116 TM7SF2 MACROD1 GC11M064153
GH11G064183 1.4 FANTOM5 ENCODE 24.7 +40.6 40581 4.4 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC TBX21 TRPT1 C11orf84 ENSG00000269038 IMMP1LP1 FERMT3 C11orf95 ENSG00000257086 PLCB3 ENSG00000256341 SNX15
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRPT1 on UCSC Golden Path with GeneCards custom track

Promoters for TRPT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040632 -46 1401 HDGF CREB3L1 ARNT AGO1 ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1

Genomic Location for TRPT1 Gene

Chromosome:
11
Start:
64,223,799 bp from pter
End:
64,226,254 bp from pter
Size:
2,456 bases
Orientation:
Minus strand

Genomic View for TRPT1 Gene

Genes around TRPT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRPT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRPT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRPT1 Gene

Proteins for TRPT1 Gene

  • Protein details for TRPT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TN4-TRPT1_HUMAN
    Recommended name:
    tRNA 2-phosphotransferase 1
    Protein Accession:
    Q86TN4
    Secondary Accessions:
    • A8MU17
    • A8MYC9
    • F5H2B2
    • Q9BSB9

    Protein attributes for TRPT1 Gene

    Size:
    253 amino acids
    Molecular mass:
    27742 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRPT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRPT1 Gene

Post-translational modifications for TRPT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRPT1 Gene

Domains & Families for TRPT1 Gene

Protein Domains for TRPT1 Gene

Suggested Antigen Peptide Sequences for TRPT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86TN4

UniProtKB/Swiss-Prot:

TRPT1_HUMAN :
  • Belongs to the KptA/TPT1 family.
Family:
  • Belongs to the KptA/TPT1 family.
genes like me logo Genes that share domains with TRPT1: view

No data available for Gene Families for TRPT1 Gene

Function for TRPT1 Gene

Molecular function for TRPT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP ribose 1,2-phosphate + nicotinamide + H(2)O.
UniProtKB/Swiss-Prot Function:
Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2-phosphate from ligated tRNA to NAD to produce ADP-ribose 1-2 cyclic phosphate.

Enzyme Numbers (IUBMB) for TRPT1 Gene

Gene Ontology (GO) - Molecular Function for TRPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000215 tRNA 2-phosphotransferase activity IEA --
GO:0008665 2-phosphotransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups IEA --
genes like me logo Genes that share ontologies with TRPT1: view
genes like me logo Genes that share phenotypes with TRPT1: view

Animal Models for TRPT1 Gene

MGI Knock Outs for TRPT1:

Animal Model Products

CRISPR Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TRPT1 Gene

Localization for TRPT1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRPT1 gene
Compartment Confidence
mitochondrion 3
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRPT1 Gene

Pathways & Interactions for TRPT1 Gene

SuperPathways for TRPT1 Gene

No Data Available

Interacting Proteins for TRPT1 Gene

Gene Ontology (GO) - Biological Process for TRPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation IEA --
GO:0008033 tRNA processing IEA --
GO:0045859 regulation of protein kinase activity IEA --
genes like me logo Genes that share ontologies with TRPT1: view

No data available for Pathways by source and SIGNOR curated interactions for TRPT1 Gene

Drugs & Compounds for TRPT1 Gene

(3) Drugs for TRPT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Nicotinamide Approved Nutra 919,923
NAD Pharma Full agonist, Agonist 0

(1) Additional Compounds for TRPT1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP-ribose 2'-phosphate
  • 2'-Phosphoadenosine 5'-[3-(D-ribofuranosyl) dihydrogen diphosphate]
  • ADP-D-Ribose 2'-phosphate
  • ADPribose 2'-phosphate
26303-90-2
genes like me logo Genes that share compounds with TRPT1: view

Transcripts for TRPT1 Gene

Unigene Clusters for TRPT1 Gene

TRNA phosphotransferase 1:
Representative Sequences:

CRISPR Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRPT1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: - - - -
SP6: - - -
SP7:
SP8: - - -
SP9: -
SP10:
SP11:

Relevant External Links for TRPT1 Gene

GeneLoc Exon Structure for
TRPT1
ECgene alternative splicing isoforms for
TRPT1

Expression for TRPT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRPT1 Gene

mRNA differential expression in normal tissues according to GTEx for TRPT1 Gene

This gene is overexpressed in Muscle - Skeletal (x4.3).

Protein differential expression in normal tissues from HIPED for TRPT1 Gene

This gene is overexpressed in Breast (29.3) and Lung (23.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRPT1 Gene



NURSA nuclear receptor signaling pathways regulating expression of TRPT1 Gene:

TRPT1

SOURCE GeneReport for Unigene cluster for TRPT1 Gene:

Hs.326586

mRNA Expression by UniProt/SwissProt for TRPT1 Gene:

Q86TN4-TRPT1_HUMAN
Tissue specificity: Widely expressed. Weakly or not expressed in lung, spleen, small intestine and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for TRPT1 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TRPT1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRPT1 Gene

Orthologs for TRPT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRPT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRPT1 34 35
  • 99.48 (n)
cow
(Bos Taurus)
Mammalia TRPT1 34 35
  • 87.22 (n)
dog
(Canis familiaris)
Mammalia TRPT1 34 35
  • 87.22 (n)
mouse
(Mus musculus)
Mammalia Trpt1 34 16 35
  • 84.95 (n)
rat
(Rattus norvegicus)
Mammalia Trpt1 34
  • 84.75 (n)
oppossum
(Monodelphis domestica)
Mammalia TRPT1 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRPT1 35
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRPT1 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trpt1 34
  • 59.36 (n)
zebrafish
(Danio rerio)
Actinopterygii trpt1 34 35
  • 57.53 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2923 34
fruit fly
(Drosophila melanogaster)
Insecta CG33057 34 35
  • 47.06 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TPT1 35 37
  • 33 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons emb1067 34
  • 48.13 (n)
rice
(Oryza sativa)
Liliopsida Os06g0134050 34
  • 49 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC2C4.12c 34
  • 48.64 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToMany
-- 35
  • 28 (a)
OneToMany
Species where no ortholog for TRPT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRPT1 Gene

ENSEMBL:
Gene Tree for TRPT1 (if available)
TreeFam:
Gene Tree for TRPT1 (if available)

Paralogs for TRPT1 Gene

No data available for Paralogs for TRPT1 Gene

Variants for TRPT1 Gene

Sequence variations from dbSNP and Humsavar for TRPT1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs142025489 Uncertain significance 64,223,393(+) TATAT(C/G/T)GGGGG downstream-variant-500B, reference, synonymous-codon
rs886043481 Uncertain significance 64,223,418(+) CGACG(C/T)GGGAG downstream-variant-500B, reference, missense
rs150686744 Benign 64,223,417(+) TCGAC(A/G)CGGGA downstream-variant-500B, reference, synonymous-codon
rs1000445974 -- 64,226,339(+) GGAAA(A/G)GGGTC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000774539 -- 64,226,560(+) GCGAC(A/G)GAGGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRPT1 Gene

Variant ID Type Subtype PubMed ID
dgv1963n54 CNV loss 21841781
esv992196 CNV deletion 20482838
nsv1159904 CNV deletion 26073780
nsv469961 CNV loss 18288195
nsv555184 CNV loss 21841781
nsv555187 CNV loss 21841781
nsv832186 CNV loss 17160897
nsv951010 CNV deletion 24416366

Variation tolerance for TRPT1 Gene

Residual Variation Intolerance Score: 72.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.29; 81.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRPT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRPT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRPT1 Gene

Disorders for TRPT1 Gene

Relevant External Links for TRPT1

Genetic Association Database (GAD)
TRPT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRPT1

No disorders were found for TRPT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRPT1 Gene

Publications for TRPT1 Gene

  1. A human homolog of the yeast gene encoding tRNA 2'- phosphotransferase: cloning, characterization and complementation analysis. (PMID: 14504659) Hu Q.-D. … Li Y.-Y. (Cell. Mol. Life Sci. 2003) 2 3 4 64
  2. Genome-wide association study of the child behavior checklist dysregulation profile. (PMID: 21784300) Mick E. … Faraone S.V. (J Am Acad Child Adolesc Psychiatry 2011) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3 64

Products for TRPT1 Gene

Sources for TRPT1 Gene

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