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Aliases for TRPT1 Gene

Aliases for TRPT1 Gene

  • TRNA Phosphotransferase 1 2 3 5
  • TRNA Splicing 2 Phosphotransferase 1 2
  • EC 2.7.1.160 4

External Ids for TRPT1 Gene

Previous GeneCards Identifiers for TRPT1 Gene

  • GC00U911626
  • GC11M063748
  • GC11M063991
  • GC11M060319

Summaries for TRPT1 Gene

GeneCards Summary for TRPT1 Gene

TRPT1 (TRNA Phosphotransferase 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and tRNA 2-phosphotransferase activity.

UniProtKB/Swiss-Prot for TRPT1 Gene

  • Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2-phosphate from ligated tRNA to NAD to produce ADP-ribose 1-2 cyclic phosphate.

Gene Wiki entry for TRPT1 Gene

Additional gene information for TRPT1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRPT1 Gene

Genomics for TRPT1 Gene

GeneHancer (GH) Regulatory Elements for TRPT1 Gene

Promoters and enhancers for TRPT1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I064224 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 584.2 +0.2 165 3.6 HDGF ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 POLR2B ZNF143 TRPT1 NUDT22 SF1 TRMT112 ZFPL1 SYVN1 PLCB3 FAU MEN1 ATG2A
GH11I064163 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 32.3 +60.8 60830 4 HDGF CLOCK FOXA2 ARID4B NEUROD1 SIN3A DMAP1 YY1 SLC30A9 ZNF766 LOC105369339 MACROD1 SF1 TRPT1 ZFPL1 PLCB3 TRMT112 ATG2A ENSG00000257086 VPS51
GH11I064183 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 24.7 +40.6 40581 4.4 CLOCK MLX ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC STIP1 GC11M064182 TRPT1 ENSG00000257086 IMMP1LP1 FERMT3 SF1 C11orf95 ZNHIT2 PLCB3
GH11I064205 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 25.8 +18.7 18659 4.4 HDGF PKNOX1 ATF1 SMAD1 ARNT YY1 TCF12 POLR2B ZNF766 ZNF143 FERMT3 TRPT1 ZFPL1 PLCB3 SF1 TRMT112 ENSG00000257086 GPR137 BAD KCNK4
GH11I064237 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 23.9 -19.1 -19065 16.6 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC PPP1R14B LOC105369340 FKBP2 PLCB3 TRPT1 LOC102723878 VEGFB TRMT112 FERMT3 GPR137
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRPT1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRPT1 gene promoter:

Genomic Locations for TRPT1 Gene

Genomic Locations for TRPT1 Gene
chr11:64,223,799-64,226,254
(GRCh38/hg38)
Size:
2,456 bases
Orientation:
Minus strand
chr11:63,991,271-63,993,726
(GRCh37/hg19)

Genomic View for TRPT1 Gene

Genes around TRPT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRPT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRPT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRPT1 Gene

Proteins for TRPT1 Gene

  • Protein details for TRPT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TN4-TRPT1_HUMAN
    Recommended name:
    tRNA 2-phosphotransferase 1
    Protein Accession:
    Q86TN4
    Secondary Accessions:
    • A8MU17
    • A8MYC9
    • F5H2B2
    • Q9BSB9

    Protein attributes for TRPT1 Gene

    Size:
    253 amino acids
    Molecular mass:
    27742 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRPT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRPT1 Gene

Post-translational modifications for TRPT1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TRPT1 Gene

Domains & Families for TRPT1 Gene

Gene Families for TRPT1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for TRPT1 Gene

Suggested Antigen Peptide Sequences for TRPT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86TN4

UniProtKB/Swiss-Prot:

TRPT1_HUMAN :
  • Belongs to the KptA/TPT1 family.
Family:
  • Belongs to the KptA/TPT1 family.
genes like me logo Genes that share domains with TRPT1: view

Function for TRPT1 Gene

Molecular function for TRPT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP ribose 1,2-phosphate + nicotinamide + H(2)O.
UniProtKB/Swiss-Prot Function:
Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2-phosphate from ligated tRNA to NAD to produce ADP-ribose 1-2 cyclic phosphate.

Enzyme Numbers (IUBMB) for TRPT1 Gene

Phenotypes From GWAS Catalog for TRPT1 Gene

Gene Ontology (GO) - Molecular Function for TRPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000215 tRNA 2-phosphotransferase activity IEA --
GO:0003674 molecular_function ND --
GO:0016740 transferase activity IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups IEA --
genes like me logo Genes that share ontologies with TRPT1: view
genes like me logo Genes that share phenotypes with TRPT1: view

Animal Models for TRPT1 Gene

MGI Knock Outs for TRPT1:

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TRPT1 Gene

Localization for TRPT1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRPT1 gene
Compartment Confidence
mitochondrion 3
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRPT1 Gene

Pathways & Interactions for TRPT1 Gene

SuperPathways for TRPT1 Gene

No Data Available

Interacting Proteins for TRPT1 Gene

Gene Ontology (GO) - Biological Process for TRPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation IEA --
GO:0008033 tRNA processing IEA --
GO:0008150 biological_process ND --
GO:0045859 regulation of protein kinase activity IEA --
genes like me logo Genes that share ontologies with TRPT1: view

No data available for Pathways by source and SIGNOR curated interactions for TRPT1 Gene

Drugs & Compounds for TRPT1 Gene

(3) Drugs for TRPT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Nicotinamide Approved, Investigational Nutra 942,946
NAD Pharma Full agonist, Agonist 0

(1) Additional Compounds for TRPT1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP-ribose 2'-phosphate
  • 2'-Phosphoadenosine 5'-[3-(D-ribofuranosyl) dihydrogen diphosphate]
  • ADP-D-Ribose 2'-phosphate
  • ADPribose 2'-phosphate
26303-90-2
genes like me logo Genes that share compounds with TRPT1: view

Transcripts for TRPT1 Gene

Unigene Clusters for TRPT1 Gene

TRNA phosphotransferase 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRPT1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: - - - -
SP6: - - -
SP7:
SP8: - - -
SP9: -
SP10:
SP11:

Relevant External Links for TRPT1 Gene

GeneLoc Exon Structure for
TRPT1
ECgene alternative splicing isoforms for
TRPT1

Expression for TRPT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRPT1 Gene

mRNA differential expression in normal tissues according to GTEx for TRPT1 Gene

This gene is overexpressed in Muscle - Skeletal (x4.3).

Protein differential expression in normal tissues from HIPED for TRPT1 Gene

This gene is overexpressed in Breast (29.3) and Lung (23.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRPT1 Gene



NURSA nuclear receptor signaling pathways regulating expression of TRPT1 Gene:

TRPT1

SOURCE GeneReport for Unigene cluster for TRPT1 Gene:

Hs.326586

mRNA Expression by UniProt/SwissProt for TRPT1 Gene:

Q86TN4-TRPT1_HUMAN
Tissue specificity: Widely expressed. Weakly or not expressed in lung, spleen, small intestine and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for TRPT1 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TRPT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRPT1 Gene

Orthologs for TRPT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRPT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRPT1 33 34
  • 99.48 (n)
cow
(Bos Taurus)
Mammalia TRPT1 33 34
  • 87.22 (n)
dog
(Canis familiaris)
Mammalia TRPT1 33 34
  • 87.22 (n)
mouse
(Mus musculus)
Mammalia Trpt1 33 16 34
  • 84.95 (n)
rat
(Rattus norvegicus)
Mammalia Trpt1 33
  • 84.75 (n)
oppossum
(Monodelphis domestica)
Mammalia TRPT1 34
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRPT1 34
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRPT1 34
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trpt1 33
  • 59.36 (n)
zebrafish
(Danio rerio)
Actinopterygii trpt1 33 34
  • 57.53 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2923 33
fruit fly
(Drosophila melanogaster)
Insecta CG33057 33 34
  • 47.06 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TPT1 34 36
  • 33 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons emb1067 33
  • 48.13 (n)
rice
(Oryza sativa)
Liliopsida Os06g0134050 33
  • 49 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC2C4.12c 33
  • 48.64 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
OneToMany
-- 34
  • 28 (a)
OneToMany
Species where no ortholog for TRPT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRPT1 Gene

ENSEMBL:
Gene Tree for TRPT1 (if available)
TreeFam:
Gene Tree for TRPT1 (if available)

Paralogs for TRPT1 Gene

No data available for Paralogs for TRPT1 Gene

Variants for TRPT1 Gene

Sequence variations from dbSNP and Humsavar for TRPT1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs150686744 benign, not specified, Leukocyte adhesion deficiency, type III 64,223,417(-) G/A/T downstream_transcript_variant
rs142025489 uncertain-significance, not specified 64,223,393(-) C/G/T downstream_transcript_variant
rs886043481 uncertain-significance, not specified 64,223,418(-) C/T downstream_transcript_variant
rs1000445974 -- 64,226,339(-) G/A upstream_transcript_variant
rs1000774539 -- 64,226,560(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TRPT1 Gene

Variant ID Type Subtype PubMed ID
dgv1963n54 CNV loss 21841781
esv992196 CNV deletion 20482838
nsv1159904 CNV deletion 26073780
nsv469961 CNV loss 18288195
nsv555184 CNV loss 21841781
nsv555187 CNV loss 21841781
nsv832186 CNV loss 17160897
nsv951010 CNV deletion 24416366

Variation tolerance for TRPT1 Gene

Residual Variation Intolerance Score: 72.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.29; 81.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRPT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRPT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRPT1 Gene

Disorders for TRPT1 Gene

Additional Disease Information for TRPT1

No disorders were found for TRPT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRPT1 Gene

Publications for TRPT1 Gene

  1. A human homolog of the yeast gene encoding tRNA 2'-phosphotransferase: cloning, characterization and complementation analysis. (PMID: 14504659) Hu QD … Li YY (Cellular and molecular life sciences : CMLS 2003) 2 3 4 58
  2. Genome-wide association study of the child behavior checklist dysregulation profile. (PMID: 21784300) Mick E … Faraone SV (Journal of the American Academy of Child and Adolescent Psychiatry 2011) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58

Products for TRPT1 Gene

Sources for TRPT1 Gene

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