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TRPT1 Gene

protein-coding   GIFtS: 51
GCID: GC11M063991

TRNA Phosphotransferase 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TRNA Phosphotransferase 11 2
TRNA Splicing 2' Phosphotransferase 11 2
TRNA 2'-Phosphotransferase 12
EC 2.7.1.1603

External Ids:    HGNC: 203161   Entrez Gene: 837072   Ensembl: ENSG000001497437   OMIM: 6104705   UniProtKB: Q86TN43   

Export aliases for TRPT1 gene to outside databases

Previous GC identifers: GC00U911626 GC11M063748 GC11M060319


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TRPT1 Gene:
TRPT1 (tRNA phosphotransferase 1) is a protein-coding gene. GO annotations related to this gene include tRNA 2'-phosphotransferase activity.

UniProtKB/Swiss-Prot: TRPT1_HUMAN, Q86TN4
Function: Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated
tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate (Probable)

Gene Wiki entry for TRPT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRPT1 gene promoter:
         ER-alpha   Pax-5   CP2   SEF-1 (1)   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRPT1 promoter sequence
   Search Chromatin IP Primers for TRPT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRPT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13

TRPT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRPT1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M063991:  view genomic region     (about GC identifiers)

Start:
63,991,271 bp from pter      End:
63,993,726 bp from pter
Size:
2,456 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TRPT1_HUMAN, Q86TN4 (See protein sequence)
Recommended Name: tRNA 2'-phosphotransferase 1  
Size: 253 amino acids; 27742 Da
Secondary accessions: A8MU17 A8MYC9 F5H2B2 Q9BSB9
Alternative splicing: 4 isoforms:  Q86TN4-1   Q86TN4-2   Q86TN4-3   Q86TN4-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRPT1: NX_Q86TN4

Explore proteomics data for TRPT1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TRPT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001028850.2  NP_001153861.1  NP_001153862.1  NP_001153864.1  NP_001153865.1  NP_113660.1  

    ENSEMBL proteins: 
     ENSP00000378051   ENSP00000439586   ENSP00000445292   ENSP00000314073   ENSP00000437741  
     ENSP00000442066   ENSP00000378050   ENSP00000438683  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002745 Ptrans_KptA/Tpt1

    Graphical View of Domain Structure for InterPro Entry Q86TN4

    ProtoNet protein and cluster: Q86TN4

    1 Blocks protein domain: IPB002745 Phosphotransferase KptA/Tpt1

    UniProtKB/Swiss-Prot: TRPT1_HUMAN, Q86TN4
    Similarity: Belongs to the KptA/TPT1 family


    Find genes that share domains with TRPT1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRPT1_HUMAN, Q86TN4
    Function: Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated
    tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate (Probable)
    Catalytic activity: 2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide
    + H(2)O

         Enzyme Number (IUBMB): EC 2.7.1.1601

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000215tRNA 2'-phosphotransferase activity IEA--
    GO:00086652'-phosphotransferase activity ----
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    Find genes that share ontologies with TRPT1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TRPT1:
     Increased viability after born 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Trpt1):
     cellular  homeostasis/metabolism 

    Find genes that share phenotypes with TRPT1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Trpt1tm1Dron for TRPT1

       genOway: Develop your customized and physiologically relevant rodent model for TRPT1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion2
    cytosol1
    endoplasmic reticulum1
    nucleus1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRPT1
    Interactions:

        Search GeneGlobe Interaction Network for TRPT1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for TRPT1 (Q86TN42, 3 ENSP000003140734) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAF2Q129333, ENSP000002476684I2D: score=5 STRING: ENSP00000247668
    KBTBD7Q8WVZ93I2D: score=1 
    GATA5ENSP000002529974STRING: ENSP00000252997
    IMMTENSP000003872624STRING: ENSP00000387262
    ZC3H14ENSP000002510384STRING: ENSP00000251038
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006388tRNA splicing, via endonucleolytic cleavage and ligation IEA--
    GO:0045859regulation of protein kinase activity IEA--

    Find genes that share ontologies with TRPT1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRPT1

    2 HMDB Compounds for TRPT1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADP-ribose 2'-phosphate2'-phosphoadenosine 5'-[3-(D-ribofuranosyl) dihydrogen diphosphate] (see all 3)26303-90-2--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRPT1 gene (6 alternative transcripts): 
    NM_001033678.3  NM_001160389.1  NM_001160390.1  NM_001160392.1  NM_001160393.1  NM_031472.3  

    Unigene Cluster for TRPT1:

    TRNA phosphotransferase 1
    Hs.326586  [show with all ESTs]
    Unigene Representative Sequence: BF973400
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394547 ENST00000546133 ENST00000536158 ENST00000539436 ENST00000544286
    ENST00000537907 ENST00000541928 ENST00000317459 ENST00000546089 ENST00000539595
    ENST00000536234 ENST00000545812 ENST00000542040 ENST00000540472 ENST00000394546(uc010rnc.2 uc010rnd.2 uc001nyo.3 uc010rnf.2 uc001nyn.3)
    ENST00000541278(uc010rne.2)
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    GenScript: all cDNA clones in your preferred vector (see all 6): TRPT1 (NM_001160393)
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    Additional mRNA sequence: 

    AY211494.1 BC005133.2 

    13 DOTS entries:

    DT.100830225  DT.456276  DT.101964595  DT.99969517  DT.100792951  DT.456277  DT.100808071  DT.120757751 
    DT.120757796  DT.95335557  DT.100775663  DT.95081685  DT.95081690 

    Selected AceView cDNA sequences (see all 153):

    AI087861 AW368800 BM982538 BM054678 AI923864 CA306231 AI740509 BU728496 
    AW328432 AW105702 BX448709 BQ010394 CK904561 CR591349 AI198728 BF063730 
    AI571406 BX373257 CR599436 AI865582 BM673765 AW328431 AA811514 AW516951 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TRPT1 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d
    SP1:                                                  -     -                                                               
    SP2:                                      -           -     -                                                               
    SP3:                                      -     -     -     -                                                               
    SP4:                                                  -     -                                                               
    SP5:                                                  -     -                             -     -                           


    ECgene alternative splicing isoforms for TRPT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRPT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGTCCCGTT
    TRPT1 Expression
    About this image

    TRPT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRPT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.326586

    UniProtKB/Swiss-Prot: TRPT1_HUMAN, Q86TN4
    Tissue specificity: Widely expressed. Weakly or not expressed in lung, spleen, small intestine and peripheral
    blood leukocytes

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TRPT1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trpt11 , 5 tRNA phosphotransferase 11, 5 84.95(n)1
    83.87(a)1
      19 (5.13 cM)5
    1073281  NM_153597.21  NP_705825.21 
     69961315 
    lizard
    (Anolis carolinensis)
    Reptilia TRPT16
    tRNA phosphotransferase 1
    64(a)
    1 ↔ 1
    GL343555.1(393389-405559)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia trpt11 tRNA phosphotransferase 1 59.36(n)
    61.19(a)
      100216285  XM_002940227.2  XP_002940273.1 
    zebrafish
    (Danio rerio)
    Actinopterygii trpt11 tRNA phosphotransferase 1 57.53(n)
    56.73(a)
      503604  NM_001013291.3  NP_001013309.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG330571 CG33057 47.06(n)
    39.22(a)
      318833  NM_176299.3  NP_788477.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TPT1(YOL102C)4 tRNA 2'-phosphotransferase, catalyzes the final step more   --   15(126689-125997) 854051  NP_014539.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons emb10671 emb1067 48.13(n)
    41.7(a)
      819141  NM_130096.4  NP_182058.2 
    rice
    (Oryza sativa)
    Liliopsida Os06g01340501 Os06g0134050 49(n)
    40.55(a)
      9267091  NM_001187655.1  NP_001174584.1 


    ENSEMBL Gene Tree for TRPT1 (if available)
    TreeFam Gene Tree for TRPT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRPT1 (see all 143)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1846469761,2
    --63911167(+) CATGGA/GGTGGC 5 -- int10--------
    rs1420951121,2
    C,F--63911300(+) GGTGAA/GTGTGC 10 T I mis12Minor allele frequency- G:0.00NA EU 5843
    rs2004580731,2
    --63911365(+) AATGTA/CCCATG 10 G syn10--------
    rs1490818831,2
    C--63911366(+) ATGTAC/TCATGG 10 D G mis11Minor allele frequency- T:0.00NA 4550
    rs1432008111,2
    C,F--63911396(+) CCTGCG/AGTGTC 10 /P /L mis11Minor allele frequency- A:0.00NA 4550
    rs23022611,2
    C,F,H--63911502(-) GTGAGG/CGGACA 5 -- int111Minor allele frequency- C:0.09EA NA NS 2354
    rs1511483391,2
    C--63911529(+) TGGCCC/TTGGTT 10 Q syn10--------
    rs1174809101,2
    C,F--63911549(+) GAGAAG/AGCCAG 10 /L /F mis13Minor allele frequency- A:0.00EA NA EU 5835
    rs1894093131,2
    --63911579(+) CAGGGC/TGAACC 10 T A mis10--------
    rs2014921261,2
    --63911684(+) GCCATC/GTGTGG 5 -- spa10--------

    HapMap Linkage Disequilibrium report for TRPT1 (63991271 - 63993726 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for TRPT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv992196CNV Deletion20482838
    dgv1165n71CNV Loss21882294
    dgv1166n71CNV Loss21882294
    dgv1156n71CNV Loss21882294
    dgv1167n71CNV Loss21882294
    dgv1164n71CNV Loss21882294
    nsv832186CNV Loss17160897
    dgv1163n71CNV Loss21882294
    nsv469961CNV Loss18288195

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610470    OMIM disorders: --


    Find genes that share disorders with TRPT1           About GenesLikeMe

    Genetic Association Database (GAD): TRPT1

    Export disorders for TRPT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRPT1 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with TRPT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human homolog of the yeast gene encoding tRNA 2'- phosphotransferase: cloning, characterization and complementation analysis. (PubMed id 14504659)1, 2, 3 Hu Q.-D.... Li Y.-Y. (Cell. Mol. Life Sci. 2003)
    2. Genome-wide association study of the child behavior checklist dysregulation profile. (PubMed id 21784300)1, 4 Mick E....Faraone S.V. (J Am Acad Child Adolesc Psychiatry 2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    5. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (Nature 2012)
    6. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    8. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (Mol. Syst. Biol. 2009)
    9. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    10. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83707 HGNC: 20316 AceView: MGC11134 Ensembl:ENSG00000149743 euGenes: HUgn83707
    ECgene: TRPT1 H-InvDB: TRPT1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRPT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRPT1 gene:
    Search GeneIP for patents involving TRPT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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