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Aliases for TRPT1 Gene

Aliases for TRPT1 Gene

  • TRNA Phosphotransferase 1 2 3
  • TRNA Splicing 2 Phosphotransferase 1 2
  • EC 4

External Ids for TRPT1 Gene

Previous GeneCards Identifiers for TRPT1 Gene

  • GC00U911626
  • GC11M063748
  • GC11M063991
  • GC11M060319

Summaries for TRPT1 Gene

GeneCards Summary for TRPT1 Gene

TRPT1 (TRNA Phosphotransferase 1) is a Protein Coding gene. GO annotations related to this gene include tRNA 2-phosphotransferase activity.

UniProtKB/Swiss-Prot for TRPT1 Gene

  • Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2-phosphate from ligated tRNA to NAD to produce ADP-ribose 1-2 cyclic phosphate.

Gene Wiki entry for TRPT1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRPT1 Gene

Genomics for TRPT1 Gene

Regulatory Elements for TRPT1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRPT1 Gene

64,223,799 bp from pter
64,226,254 bp from pter
2,456 bases
Minus strand

Genomic View for TRPT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRPT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRPT1 Gene

Proteins for TRPT1 Gene

  • Protein details for TRPT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    tRNA 2-phosphotransferase 1
    Protein Accession:
    Secondary Accessions:
    • A8MU17
    • A8MYC9
    • F5H2B2
    • Q9BSB9

    Protein attributes for TRPT1 Gene

    253 amino acids
    Molecular mass:
    27742 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRPT1 Gene


neXtProt entry for TRPT1 Gene

Proteomics data for TRPT1 Gene at MOPED

Post-translational modifications for TRPT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRPT1 Gene

Domains for TRPT1 Gene

Protein Domains for TRPT1 Gene

Suggested Antigen Peptide Sequences for TRPT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the KptA/TPT1 family.
  • Belongs to the KptA/TPT1 family.
genes like me logo Genes that share domains with TRPT1: view

No data available for Gene Families for TRPT1 Gene

Function for TRPT1 Gene

Molecular function for TRPT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP ribose 1,2-phosphate + nicotinamide + H(2)O
UniProtKB/Swiss-Prot Function:
Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2-phosphate from ligated tRNA to NAD to produce ADP-ribose 1-2 cyclic phosphate.

Enzyme Numbers (IUBMB) for TRPT1 Gene

Gene Ontology (GO) - Molecular Function for TRPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000215 tRNA 2-phosphotransferase activity IEA --
GO:0008665 2-phosphotransferase activity --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with TRPT1: view

Phenotypes for TRPT1 Gene

genes like me logo Genes that share phenotypes with TRPT1: view

Animal Models for TRPT1 Gene

MGI Knock Outs for TRPT1:

Animal Model Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for TRPT1 Gene

Localization for TRPT1 Gene

Subcellular locations from

Jensen Localization Image for TRPT1 Gene COMPARTMENTS Subcellular localization image for TRPT1 gene
Compartment Confidence
mitochondrion 2
cytosol 1
endoplasmic reticulum 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRPT1 Gene

Pathways for TRPT1 Gene

SuperPathways for TRPT1 Gene

No Data Available

Interacting Proteins for TRPT1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q86TN4-TRPT1_HUMAN ENSP00000378050 for TRPT1 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for TRPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation IEA --
GO:0045859 regulation of protein kinase activity IEA --
genes like me logo Genes that share ontologies with TRPT1: view

No data available for Pathways by source for TRPT1 Gene

Compounds for TRPT1 Gene

(2) HMDB Compounds for TRPT1 Gene

Compound Synonyms Cas Number PubMed IDs
ADP-ribose 2'-phosphate
  • 2'-phosphoadenosine 5'-[3-(D-ribofuranosyl) dihydrogen diphosphate]
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
genes like me logo Genes that share compounds with TRPT1: view

Transcripts for TRPT1 Gene

Unigene Clusters for TRPT1 Gene

TRNA phosphotransferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRPT1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: - - - -
SP6: - - -
SP8: - - -
SP9: -

Relevant External Links for TRPT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRPT1 Gene

mRNA expression in normal human tissues for TRPT1 Gene

mRNA differential expression in normal tissues according to GTEx for TRPT1 Gene

This gene is overexpressed in Muscle - Skeletal (4.3).

Protein differential expression in normal tissues for TRPT1 Gene

This gene is overexpressed in Breast (29.3) and Lung (23.8).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TRPT1 Gene

SOURCE GeneReport for Unigene cluster for TRPT1 Gene Hs.326586

mRNA Expression by UniProt/SwissProt for TRPT1 Gene

Tissue specificity: Widely expressed. Weakly or not expressed in lung, spleen, small intestine and peripheral blood leukocytes.
genes like me logo Genes that share expressions with TRPT1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Expression partners for TRPT1 Gene

Orthologs for TRPT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRPT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRPT1 35
  • 87.22 (n)
  • 84.19 (a)
TRPT1 36
  • 84 (a)
(Canis familiaris)
Mammalia TRPT1 35
  • 87.22 (n)
  • 86.96 (a)
TRPT1 36
  • 87 (a)
(Mus musculus)
Mammalia Trpt1 35
  • 84.95 (n)
  • 83.87 (a)
Trpt1 16
Trpt1 36
  • 84 (a)
(Pan troglodytes)
Mammalia TRPT1 35
  • 99.48 (n)
  • 99.61 (a)
TRPT1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Trpt1 35
  • 84.75 (n)
  • 83 (a)
(Monodelphis domestica)
Mammalia TRPT1 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia TRPT1 36
  • 63 (a)
(Anolis carolinensis)
Reptilia TRPT1 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trpt1 35
  • 59.36 (n)
  • 61.19 (a)
(Danio rerio)
Actinopterygii trpt1 35
  • 57.53 (n)
  • 56.73 (a)
trpt1 36
  • 53 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2923 35
fruit fly
(Drosophila melanogaster)
Insecta CG33057 35
  • 47.06 (n)
  • 39.22 (a)
CG33057 36
  • 38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TPT1 36
  • 33 (a)
TPT1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons emb1067 35
  • 48.13 (n)
  • 41.7 (a)
(Oryza sativa)
Liliopsida Os06g0134050 35
  • 49 (n)
  • 40.55 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC2C4.12c 35
  • 48.64 (n)
  • 45.92 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
-- 36
  • 28 (a)
Species with no ortholog for TRPT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRPT1 Gene

Gene Tree for TRPT1 (if available)
Gene Tree for TRPT1 (if available)

Paralogs for TRPT1 Gene

No data available for Paralogs for TRPT1 Gene

Variants for TRPT1 Gene

Sequence variations from dbSNP and Humsavar for TRPT1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
VAR_030134 -
VAR_030135 -
VAR_030136 -

Structural Variations from Database of Genomic Variants (DGV) for TRPT1 Gene

Variant ID Type Subtype PubMed ID
dgv1156n71 CNV Loss 21882294
nsv469961 CNV Loss 18288195
dgv1163n71 CNV Loss 21882294
dgv1164n71 CNV Loss 21882294
dgv1165n71 CNV Loss 21882294
dgv1166n71 CNV Loss 21882294
nsv832186 CNV Loss 17160897
dgv1167n71 CNV Loss 21882294
esv992196 CNV Deletion 20482838

Relevant External Links for TRPT1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRPT1 Gene

Disorders for TRPT1 Gene

Relevant External Links for TRPT1

Genetic Association Database (GAD)

No disorders were found for TRPT1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TRPT1 Gene

Publications for TRPT1 Gene

  1. A human homolog of the yeast gene encoding tRNA 2'- phosphotransferase: cloning, characterization and complementation analysis. (PMID: 14504659) Hu Q.-D. … Li Y.-Y. (Cell. Mol. Life Sci. 2003) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genome-wide association study of the child behavior checklist dysregulation profile. (PMID: 21784300) Mick E. … Faraone S.V. (J Am Acad Child Adolesc Psychiatry 2011) 3 48
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for TRPT1 Gene

Sources for TRPT1 Gene

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