Aliases for TRPS1 Gene
External Ids for TRPS1 Gene
Previous GeneCards Identifiers for TRPS1 Gene
This gene encodes a transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein. Binding of the encoded protein to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity. Defects in this gene are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III. [provided by RefSeq, Jul 2008]
GeneCards Summary for TRPS1 Gene
TRPS1 (Trichorhinophalangeal Syndrome I) is a Protein Coding gene. Diseases associated with TRPS1 include trichorhinophalangeal syndrome, type ii and trichorhinophalangeal syndrome, type i. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is GATA5.
UniProtKB/Swiss-Prot for TRPS1 Gene
Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes.