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Aliases for TRPM8 Gene

Aliases for TRPM8 Gene

  • Transient Receptor Potential Cation Channel Subfamily M Member 8 2 3 5
  • Long Transient Receptor Potential Channel 6 3 4
  • Transient Receptor Potential P8 3 4
  • LTrpC-6 3 4
  • Trp-P8 3 4
  • LTRPC6 3 4
  • TRPP8 3 4
  • Transient Receptor Potential Cation Channel, Subfamily M, Member 8 2
  • Transient Receptor Potential Subfamily M Member 8 3
  • Transient Receptor Melastatin 8 Variant 1 3
  • Transient Receptor Melastatin 8 Variant 2 3
  • Short Form Of The TRPM8 Cationic Channel 3

External Ids for TRPM8 Gene

Previous GeneCards Identifiers for TRPM8 Gene

  • GC02P232834
  • GC02P233507
  • GC02P234842
  • GC02P235112
  • GC02P234608
  • GC02P234490
  • GC02P226625

Summaries for TRPM8 Gene

GeneCards Summary for TRPM8 Gene

TRPM8 (Transient Receptor Potential Cation Channel Subfamily M Member 8) is a Protein Coding gene. Diseases associated with TRPM8 include Prostate Cancer and Dentin Sensitivity. Among its related pathways are Ion channel transport and Development Endothelin-1/EDNRA signaling. GO annotations related to this gene include protein homodimerization activity and calcium channel activity. An important paralog of this gene is TRPM2.

UniProtKB/Swiss-Prot for TRPM8 Gene

  • Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration (PubMed:25559186). Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.

Tocris Summary for TRPM8 Gene

  • The melastatin-related receptor family (TRPM) is the largest subfamily of the transient receptor potential (TRP) superfamily of ion channels. It contains 8 known members, subdivided into 4 groups, which perform a range of functions including detection of taste and osmolarity.

Gene Wiki entry for TRPM8 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRPM8 Gene

Genomics for TRPM8 Gene

Regulatory Elements for TRPM8 Gene

Enhancers for TRPM8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F234482 1.6 FANTOM5 Ensembl ENCODE 9 +573.7 573675 16.9 ATF1 PKNOX1 SIN3A FEZF1 ZNF2 YY1 GLIS2 FOS REST AEBP2 ARL4C TRPM8 HSPE1P9
GH02F233867 0.9 ENCODE 10.3 -49.0 -48971 1.1 ATF1 CREB3L1 ZNF76 SIN3A ZNF2 CREM ZBTB2 SMAD5 HCFC1 ZNF518A MSL3P1 TRPM8 UGT1A4 HJURP ENSG00000279809
GH02F233966 0.7 ENCODE 9.8 +49.2 49190 0.2 GATAD2A ELF3 TEAD1 FOXA3 ZBTB40 MIER3 ZNF366 HDAC2 ATF3 FOXK2 TRPM8 ENSG00000237581 SPP2
GH02F234025 0.7 Ensembl ENCODE 9.8 +109.2 109226 3.0 ELF3 RAD21 SPP2 TRPM8 ENSG00000237581
GH02F233973 1.6 FANTOM5 Ensembl ENCODE 2.9 +58.4 58427 5.2 PKNOX1 ATF1 MLX ARID4B SIN3A ZNF2 ZNF48 YY1 GLIS2 ZNF207 USP40 SCARNA6 TRPM8 ENSG00000237581 SPP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRPM8 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the TRPM8 gene promoter:

Genomic Location for TRPM8 Gene

Chromosome:
2
Start:
233,917,362 bp from pter
End:
234,019,522 bp from pter
Size:
102,161 bases
Orientation:
Plus strand

Genomic View for TRPM8 Gene

Genes around TRPM8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRPM8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRPM8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRPM8 Gene

Proteins for TRPM8 Gene

  • Protein details for TRPM8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z2W7-TRPM8_HUMAN
    Recommended name:
    Transient receptor potential cation channel subfamily M member 8
    Protein Accession:
    Q7Z2W7
    Secondary Accessions:
    • A0AVG2
    • Q3YFM7
    • Q6QNH9
    • Q8TAC3
    • Q8TDX8
    • Q9BVK1

    Protein attributes for TRPM8 Gene

    Size:
    1104 amino acids
    Molecular mass:
    127685 Da
    Quaternary structure:
    • Homotetramer (By similarity). Isoform 2 and isoform 3 interact with the C-terminus of isoform 1 in a thermosensitive manner with decreased interaction at 21 degrees Celsius compared to 37 degrees Celsius. Interacts (via N-terminus and C-terminus domains) with TCAF1; the interaction stimulates TRPM8 channel activity (PubMed:25559186). Interacts (via N-terminus and C-terminus domains) with TCAF2 isoform 2; the interaction inhibits TRPM8 channel activity (PubMed:25559186).
    Miscellaneous:
    • Its expression in most prostate tumors as well as the presence of an immunogenic epitope suggest that it may be suitable for the design of peptide vaccination strategies for prostate cancers.
    • The sensation of coolness triggered by eucalyptol or menthol may be explained by the fact that menthol and cool temperatures sensations are detected by this protein.
    SequenceCaution:
    • Sequence=AAH01135.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAS45276.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRPM8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRPM8 Gene

Post-translational modifications for TRPM8 Gene

  • Glycosylation at Asn 934
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TRPM8 Gene

Domains & Families for TRPM8 Gene

Gene Families for TRPM8 Gene

Protein Domains for TRPM8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TRPM8 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z2W7

UniProtKB/Swiss-Prot:

TRPM8_HUMAN :
  • The coiled coil region is required for multimerization.
  • Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM8 sub-subfamily.
Domain:
  • The coiled coil region is required for multimerization.
Family:
  • Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM8 sub-subfamily.
genes like me logo Genes that share domains with TRPM8: view

Function for TRPM8 Gene

Molecular function for TRPM8 Gene

UniProtKB/Swiss-Prot Function:
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration (PubMed:25559186). Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.

Gene Ontology (GO) - Molecular Function for TRPM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005262 calcium channel activity TAS --
GO:0005515 protein binding IPI 25559186
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with TRPM8: view
genes like me logo Genes that share phenotypes with TRPM8: view

Animal Models for TRPM8 Gene

MGI Knock Outs for TRPM8:

Animal Model Products

  • Taconic Biosciences Mouse Models for TRPM8

miRNA for TRPM8 Gene

miRTarBase miRNAs that target TRPM8

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRPM8 Gene

Localization for TRPM8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRPM8 Gene

Cell membrane; Multi-pass membrane protein. Membrane raft. Endoplasmic reticulum membrane. Note=Localizes to membrane rafts but is also located in the cell membrane outside of these regions where channel response to cold is enhanced compared to membrane rafts (By similarity). Located in the endoplasmic reticulum in prostate cancer cells. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRPM8 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
extracellular 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TRPM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TRPM8: view

Pathways & Interactions for TRPM8 Gene

genes like me logo Genes that share pathways with TRPM8: view

Pathways by source for TRPM8 Gene

Gene Ontology (GO) - Biological Process for TRPM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006812 cation transport IEA --
GO:0006816 calcium ion transport IEA --
GO:0006874 cellular calcium ion homeostasis IEA --
genes like me logo Genes that share ontologies with TRPM8: view

No data available for SIGNOR curated interactions for TRPM8 Gene

Drugs & Compounds for TRPM8 Gene

(54) Drugs for TRPM8 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Menthol Approved Pharma Partial agonist, Activator, activator, Target, inducer 2353
cannabidiol Approved, Investigational Pharma Partial agonist, Agonist 0
Clotrimazole Approved, Vet_approved Pharma Inhibition, Pore Blocker, inhibitor Cytochrome P450 inhibitor; antifungal 35
AMTB hydrochloride Pharma TRPM8 blocker 0
WS 12 Pharma TRPM8 agonist; cooling agent 0

(6) Additional Compounds for TRPM8 Gene - From: IUPHAR, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Delta<sup>9</sup>-tetrahydrocannabinol
Partial agonist, Agonist
WS-12
Activator
sodium
  • Sodium
  • Sodium ion
7440-23-5
CIM 0216
1031496-06-6
M8 B hydrochloride
883976-12-3

(5) Tocris Compounds for TRPM8 Gene

Compound Action Cas Number
AMTB hydrochloride TRPM8 blocker 926023-82-7
CIM 0216 Selective TRPM3 agonist 1031496-06-6
M8 B hydrochloride Potent and selective TRPM8 channel blocker 883976-12-3
TC-I 2014 Potent TRPM8 antagonist 1221349-53-6
WS 12 TRPM8 agonist; cooling agent 68489-09-8

(37) ApexBio Compounds for TRPM8 Gene

Compound Action Cas Number
5'-Iodoresiniferatoxin 535974-91-5
6'-Iodoresiniferatoxin 335151-55-8
9-Phenanthrol 484-17-3
AMTB hydrochloride 926023-82-7
BCTC 393514-24-4
EIPA 1154-25-2
GSK 2193874 1336960-13-4
GsMTx4
HC 067047 883031-03-6
Icilin TRPM8/ hENaCδ agonist 36945-98-9
JNJ 17203212 821768-06-3
L-R4W2 206350-79-0
ML 204 5465-86-1
ML SA1 332382-54-4
Nonivamide 2444-46-4
OLDA 105955-11-1
Olvanil 58493-49-5
Ononetin 487-49-0
PALDA 136181-87-8
Phenamil 1161-94-0
Polygodial 6754-20-7
PPAHV 175796-50-6
Pyr3 1160514-60-2
Resiniferatoxin 57444-62-9
RN 1734 946387-07-1
RN 1747 1024448-59-6
RQ-00203078 Selective and orally active TRPM8 antagonist 1254205-52-1
SB 366791 472981-92-3
SB 452533 459429-39-1
SN 2 823218-99-1
STEARDA 105955-10-0
TC-I 2000 1159996-20-9
TCS 5861528 332117-28-9
TRPC6 inhibitor 1333207-63-8
WS 12 68489-09-8
WS 3 39711-79-0
α-Spinasterol 481-18-5
genes like me logo Genes that share compounds with TRPM8: view

Drug Products

Transcripts for TRPM8 Gene

Unigene Clusters for TRPM8 Gene

Transient receptor potential cation channel, subfamily M, member 8:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRPM8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
SP1: - - - - - -
SP2:
SP3:
SP4: -
SP5:
SP6:

ExUns: 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for TRPM8 Gene

GeneLoc Exon Structure for
TRPM8
ECgene alternative splicing isoforms for
TRPM8

Expression for TRPM8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRPM8 Gene

mRNA differential expression in normal tissues according to GTEx for TRPM8 Gene

This gene is overexpressed in Prostate (x24.5) and Liver (x24.4).

Protein differential expression in normal tissues from HIPED for TRPM8 Gene

This gene is overexpressed in Plasma (62.2) and Heart (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRPM8 Gene



Protein tissue co-expression partners for TRPM8 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRPM8 Gene:

TRPM8

SOURCE GeneReport for Unigene cluster for TRPM8 Gene:

Hs.366053

mRNA Expression by UniProt/SwissProt for TRPM8 Gene:

Q7Z2W7-TRPM8_HUMAN
Tissue specificity: Expressed in prostate. Also expressed in prostate tumors and in non-prostatic primary tumors such as colon, lung, breast and skin tumors.
genes like me logo Genes that share expression patterns with TRPM8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TRPM8 Gene

Orthologs for TRPM8 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRPM8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRPM8 34 35
  • 98.56 (n)
dog
(Canis familiaris)
Mammalia TRPM8 34 35
  • 91.49 (n)
oppossum
(Monodelphis domestica)
Mammalia TRPM8 35
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRPM8 34 35
  • 90.4 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TRPM8 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trpm8 34 16 35
  • 88.16 (n)
rat
(Rattus norvegicus)
Mammalia Trpm8 34
  • 87.38 (n)
chicken
(Gallus gallus)
Aves TRPM8 34 35
  • 77.26 (n)
lizard
(Anolis carolinensis)
Reptilia TRPM8 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trpm8 34
  • 71.94 (n)
fruit fly
(Drosophila melanogaster)
Insecta trpm 35
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gtl-2 35
  • 20 (a)
ManyToMany
gtl-1 35
  • 17 (a)
ManyToMany
gon-2 35
  • 14 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
OneToMany
Species where no ortholog for TRPM8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TRPM8 Gene

ENSEMBL:
Gene Tree for TRPM8 (if available)
TreeFam:
Gene Tree for TRPM8 (if available)

Paralogs for TRPM8 Gene

Paralogs for TRPM8 Gene

(6) SIMAP similar genes for TRPM8 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TRPM8: view

Variants for TRPM8 Gene

Sequence variations from dbSNP and Humsavar for TRPM8 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1003540 -- 233,917,239(+) CTGCT(A/G)TGCTT upstream-variant-2KB
rs1003756 -- 233,921,255(-) aattc(A/G)gttgt intron-variant
rs1003757 -- 233,921,224(-) actga(C/T)gtgat intron-variant
rs1004478 -- 233,917,250(-) CTAAA(C/G)CCTCC upstream-variant-2KB
rs1008355 -- 233,981,002(-) aaact(C/T)ctggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRPM8 Gene

Variant ID Type Subtype PubMed ID
nsv953206 CNV deletion 24416366
nsv476571 CNV novel sequence insertion 20440878
nsv475378 CNV novel sequence insertion 20440878
nsv1013712 CNV loss 25217958
dgv1220e212 CNV loss 25503493

Variation tolerance for TRPM8 Gene

Residual Variation Intolerance Score: 5.53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.14; 93.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRPM8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRPM8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRPM8 Gene

Disorders for TRPM8 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TRPM8 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, hereditary, 5
dentin sensitivity
  • sensitive dentin
migraine with or without aura 1
  • migraine
- elite association - COSMIC cancer census association via MalaCards
Search TRPM8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TRPM8

Genetic Association Database (GAD)
TRPM8
Human Genome Epidemiology (HuGE) Navigator
TRPM8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRPM8
genes like me logo Genes that share disorders with TRPM8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRPM8 Gene

Publications for TRPM8 Gene

  1. Trafficking and assembly of the cold-sensitive TRPM8 channel. (PMID: 17065148) Erler I. … Niemeyer B.A. (J. Biol. Chem. 2006) 3 4 22 64
  2. Novel role of cold/menthol-sensitive transient receptor potential melastatine family member 8 (TRPM8) in the activation of store- operated channels in LNCaP human prostate cancer epithelial cells. (PMID: 16174775) Thebault S. … Prevarskaya N. (J. Biol. Chem. 2005) 3 4 22 64
  3. Identification of an HLA-A*0201-restricted T-cell epitope derived from the prostate cancer-associated protein trp-p8. (PMID: 12858355) Kiessling A. … Rieber E.P. (Prostate 2003) 3 4 22 64
  4. TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity. (PMID: 25559186) Gkika D. … Prevarskaya N. (J. Cell Biol. 2015) 3 4 64
  5. Regulation of activity of transient receptor potential melastatin 8 (TRPM8) channel by its short isoforms. (PMID: 22128173) Bidaux G. … Prevarskaya N. (J. Biol. Chem. 2012) 3 4 64

Products for TRPM8 Gene

Sources for TRPM8 Gene

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