TRPM8 Gene
protein-coding GIFtS: 57
GCID: GC02P234842
|
|
transient receptor potential cation channel, subfamily M,...
| |
Aliases
for TRPM8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transient Receptor Potential Cation Channel, Subfamily M, Member 81 2 | | Short Form Of The TRPM8 Cationic Channel2 | | TRPP82 3 5 | | Transient Receptor Potential Cation Channel Subfamily M Member 82 | | Long Transient Receptor Potential Channel 62 3 | | Transient Receptor Potential Subfamily M Member 82 | | Transient Receptor Potential P82 3 | | Trp-P81 | | LTRPC62 3 | | LTrpC63 | | LTrpC-62 3 | | Trp-P81 |
Export aliases for TRPM8 gene to outside databasesPrevious GC identifers: GC02P232834 GC02P233507 GC02P235112 GC02P234608 GC02P234490 GC02P226625 |
Summaries
for TRPM8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TRPM8_HUMAN, Q7Z2W7Function: Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, bybeing activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold andmodulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, andcesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upondepolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. Thechemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membranepotentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated withvoltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calciumselectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poorcationic selectivity
 summary
for TRPM8: The melastatin-related receptor family (TRPM) is the largest subfamily of the transient receptor potential
(TRP) superfamily of ion channels. It contains 8 known members, subdivided into 4 groups, which perform a
range of functions including detection of taste and osmolarity, and control of cell proliferation. Members
of the TRPM subfamily are grouped on the basis of sequence homology. The first subgroup includes TRPM1 and
TRPM3; the second, TRPM6 and TRPM7; the third, TRPM2 and TRPM8; and the fourth, TRPM4 and TRPM5. TRPM
channels are involved in a range of cellular processes, including insulin secretion (TRPM2, TRPM4), Mg2+
homeostasis (TRPM6, TRPM7), and cold signaling (TRPM8). TRPM8 is also known as CMR1 (cold and menthol
receptor 1) due to its interaction with menthol. TRPM channels play an important role in numerous vascular
processes - including mechanosensory transduction and vascular inflammation - and such properties could make
TRPM channels key therapeutic targets for the treatment of vascular disease.
Gene Wiki entry for TRPM8
|
Genomic Views
for TRPM8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005120.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TRPM8 gene promoter:
AML1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRPM8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRPM8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q37.1 Ensembl cytogenetic band: 2q37.1 HGNC cytogenetic band: 2q37TRPM8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P234842: view genomic region
(about GC identifiers)
Start:
|
234,826,043 bp from pter |
End:
|
234,928,166 bp from pter |
Size:
|
102,124 bases |
Orientation:
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plus strand |
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Proteins
for TRPM8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TRPM8_HUMAN, Q7Z2W7 (See
protein sequence)Recommended Name: Transient receptor potential cation channel subfamily M member 8 Size: 1104 amino acids; 127685 Da
Subunit: Homotetramer (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein. Membrane raft. Endoplasmic reticulum membrane.Note=Localizes to membrane rafts but is also located in the cell membrane outside of these regions where channelresponse to cold is enhanced compared to membrane rafts (By similarity). Located in the endoplasmic reticulum inprostate cancer cells
Miscellaneous: The sensation of coolness triggered by eucalyptol or menthol may be explained by the fact that mentholand cool temperatures sensations are detected by this protein
Miscellaneous: Its expression in most prostate tumors as well as the presence of an immunogenic epitope suggest that itmay be suitable for the design of peptide vaccination strategies for prostate cancers
Secondary accessions: Q3YFM7 Q6QNH9 Q8TAC3 Q8TDX8 Q9BVK1Alternative splicing: 3 isoforms: Q7Z2W7-1 Q7Z2W7-2 Q7Z2W7-3 Explore the universe of human proteins at neXtProt for TRPM8: NX_Q7Z2W7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7Z2W7
TRPM8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_076985.4
ENSEMBL proteins: ENSP00000323926 ENSP00000396745 ENSP00000347956 ENSP00000386771 ENSP00000414198 ENSP00000390609 ENSP00000404423
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
TRPM8 for ontologies About GeneDecksing
TRPM8 Antibody Products:
Assay Products for TRPM8: |
Protein
Domains /
Families
for TRPM8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRPM8 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q7Z2W7ProtoNet protein and cluster: Q7Z2W7 UniProtKB/Swiss-Prot: TRPM8_HUMAN, Q7Z2W7Domain: The coiled coil region is required for multimerizationSimilarity: Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM8 sub-subfamily |
Function
for TRPM8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TRPM8_HUMAN, Q7Z2W7Function: Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, bybeing activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold andmodulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, andcesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upondepolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. Thechemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membranepotentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated withvoltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calciumselectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poorcationic selectivity
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRPM8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRPM8 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: TRPM8 (NM_024080) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRPM8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPM8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPM8 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005216 | ion channel activity |
IEA | -- | | GO:0005262 | calcium channel activity |
-- | -- | | GO:0042803 | protein homodimerization activity |
-- | -- |
TRPM8 for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for TRPM8:
Animal Models:
Mouse knock-outs for TRPM8: Trpm8tm1Jul Trpm8tm1Apat Trpm8tm1Lex
3 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Trpm8):
TRPM8 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TRPM8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Calcium channels | | | 2 | Sodium channels and transporters: inward current | | | 3 | CREB Pathway | | | 4 | Potassium Channels | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 EMD Millipore Pathways for TRPM8
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TRPM8
TRPM8 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRPM8
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
TRPM8 for ontologies About GeneDecksing
|
Drugs & Compounds
for TRPM8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TRPM8 for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for TRPM8 |
Compounds for TRPM8 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| Icilin | Activates a novel cold receptor. Cooling agent | [36945-98-9] | | 2-APB | IP3 receptor antagonist. Also TRP channel modulator | [524-95-8] | | WS 3 | TRPM8 agonist; cooling agent | [39711-79-0] | | WS 12 | TRPM8 agonist; cooling agent | [68489-09-8] |
3 HMDB Compounds for TRPM8 About this table
1 DrugBank Compound for TRPM8 About this table
3 Novoseek chemical compound relationships for TRPM8 gene About this table
Search CenterWatch for drugs/clinical trials and news about TRPM8
|
Transcripts
for TRPM8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TRPM8 gene: NM_024080.4 Unigene Cluster for TRPM8: Transient receptor potential cation channel, subfamily M, member 8 Hs.366053 [show with all ESTs]Unigene Representative Sequence: NM_02408014 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000324695(uc002vvh.3 uc010fyj.3 uc010fyk.3) ENST00000444298
ENST00000355722(uc002vvi.3) ENST00000409625(uc002vvj.3) ENST00000479332
ENST00000487033 ENST00000490797 ENST00000456930 ENST00000477698 ENST00000475044
ENST00000477103 ENST00000439148 ENST00000466594 ENST00000433712
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRPM8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRPM8 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TRPM8 (NM_024080) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRPM8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPM8 |
Additional cDNA sequence: AB061779.1 AK303811.1 AY328400.1 AY532375.1 AY532376.1 BC001135.2 BC033137.1 BC126342.1 BC143819.1 DQ139309.1 FJ895300.1 5 DOTS entries: DT.40241919 DT.40284818 DT.100018567 DT.120939787 DT.91691062 24/40 AceView cDNA sequences (see all 40): BF477681 AY328400 AA622057 AV650700 AY532376 AB061779 AI272941 AI670079 BE274448 BC001135 BX090897 AY532375 BC033137 AI420227 BF939313 BE390627 BU532384 AA370110 BX283818 AY090109 NM_024080 AW451174 AW962749 BG567490
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TRPM8 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · |
|---|
|
| SP1: | | | | | - | | | | - | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 21b | ^ | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 |
|---|
|
| SP1: | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TRPM8
|
Expression
for TRPM8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRPM8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAAAACCAC
About this image
See TRPM8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRPM8
SOURCE GeneReport for Unigene cluster: Hs.366053
UniProtKB/Swiss-Prot: TRPM8_HUMAN, Q7Z2W7Tissue specificity: Expressed in prostate. Also expressed in prostate tumors and in non-prostatic primary tumors suchas colon, lung, breast and skin tumors
SABiosciences Expression via Pathway-Focused PCR Array including TRPM8:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRPM8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRPM8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRPM8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRPM8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPM8 |
Orthologs
for TRPM8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TRPM8 gene from 3/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TRPM81 |
transient receptor potential cation channel, subfamily more |
77.26(n)
81.37(a) |
|
424025 NM_001007082.1 NP_001007083.1 |
lizard
(Anolis carolinensis) |
Reptilia |
TRPM86 |
-- |
82(a) |
1 ↔ 1 |
1(119299304-119365176) |
worm
(Caenorhabditis elegans) |
Secernentea |
ced-116 |
Protein ced-11 |
10(a) |
possible ortholog |
III(9119482-9125073) |
ENSEMBL Gene Tree for TRPM8 (if available)
TreeFam Gene Tree for TRPM8 (if available) |
Paralogs
for TRPM8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TRPM8 gene
- TRPM22 TRPM52 TRPM72 TRPM12 TRPM62 TRPM42 TRPM32
7 SIMAP similar genes for TRPM8 using alignment to 6 protein entries: TRPM8_HUMAN (see all proteins):TRPM2 TRPM3 MLSN2 TRPM1 TRPM5 TRPM6
TRPM4
TRPM8 for paralogs About GeneDecksing
|
Genomic Variants
for TRPM8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TRPM8 (234826043 - 234928166 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TRPM8: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRPM8 |
|
Disorders
/ Diseases
for TRPM8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TRPM8 for disorders About GeneDecksing
OMIM gene information: 606678
OMIM disorders: --
19  diseases for TRPM8: About MalaCardsdentin sensitivity aspiration pneumonia insensitivity to pain vascular disease
allergic rhinitis rhinitis diabetic neuropathy neuroendocrine tumor
neuropathy prostate cancer migraine prostatitis
glioblastoma pneumonia neuroblastoma melanoma
adenocarcinoma pancreatitis neuronitis
2 diseases from the University of Copenhagen DISEASES database for TRPM8:Prostate cancer Pain agnosia 2 Novoseek disease relationships for TRPM8 gene About this table
Human Genome Epidemiology (HuGE) Navigator: TRPM8 (3 documents)
Export disorders for TRPM8 gene to outside databases
|
Publications
for TRPM8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRPM8 gene, integrated from 9 sources (see all 97):
(articles sorted by number of sources associating them with TRPM8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Novel role of cold/menthol-sensitive transient receptor potential melastatine family member 8 (TRPM8) in the activation of store- operated channels in LNCaP human prostate cancer epithelial cells. (PubMed id 16174775)1, 2, 9 Thebault S.... Prevarskaya N. (2005)
- Identification of an HLA-A*0201-restricted T-cell epitope derived from the prostate cancer-associated protein trp-p8. (PubMed id 12858355)1, 2, 9 Kiessling A.... Rieber E.P. (2003)
- Trafficking and assembly of the cold-sensitive TRPM8 channel. (PubMed id 17065148)1, 2, 9 Erler I....Niemeyer B.A. (2006)
- International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. (PubMed id 16382100)1, 3 Clapham D.E....Schultz G. (2005)
- The principle of temperature-dependent gating in cold- and heat- sensitive TRP channels. (PubMed id 15306801)1, 2 Voets T....Nilius B. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins. (PubMed id 11325849)1, 2 Tsavaler L.... Laus R. (2001)
- Cool (TRPM8) and hot (TRPV1) receptors in the bladder and male genital tract. (PubMed id 15311065)7, 9 Stein R.J....De Miguel F. (2004)
- Regulation of transient receptor potential channels of melastatin type 8 (TRPM8): effect of cAMP, cannabinoid CB(1) receptors and endovanilloids. (PubMed id 17428469)1, 9 De Petrocellis L....Di Marzo V. (2007)
- Characterisation of TRPM8 as a pharmacophore receptor. (PubMed id 17517434)1, 9 Bodding M....Flockerzi V. (2007)
|
External Searches for TRPM8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TRPM8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRPM8 gene
(According to HUGE)
About This Section
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Specialized Databases showing TRPM8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for TRPM8 gene:
Search GeneIP for patents involving TRPM8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TRPM8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for TRPM8 | | OriGene shRNA RFP for TRPM8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRPM8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRPM8 | | | OriGene Protein Over-expression Lysate for TRPM8 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TRPM8 | | OriGene 3'-UTR Clone for TRPM8 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRPM8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRPM8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TRPM8 | | OriGene Custom Protein Services for TRPM8 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRPM8 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRPM8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRPM8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRPM8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRPM8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRPM8 |
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| | | | Tocris compounds for TRPM8 |
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 | | | TRPM8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPM8 |
|  |  |  | | | | ThermoFisher Antibody for TRPM8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPM8 |
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