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TRPM8 Gene

protein-coding   GIFtS: 64
GCID: GC02P234842

Transient Receptor Potential Cation Channel, Subfamily M,...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transient Receptor Potential Cation Channel, Subfamily M, Member 81 2     Transient Receptor Melastatin 82
TRPP82 3 5     Transient Receptor Potential Cation Channel Subfamily M Member 82
Long Transient Receptor Potential Channel 62 3     Transient Receptor Potential Subfamily M Member 82
Transient Receptor Potential P82 3     trp-p82
LTRPC62 3     LTrpC63
LTrpC-62 3     Trp-p83
Short Form Of The TRPM8 Cationic Channel2     

External Ids:    HGNC: 179611   Entrez Gene: 790542   Ensembl: ENSG000001444817   OMIM: 6066785   UniProtKB: Q7Z2W73   

Export aliases for TRPM8 gene to outside databases

Previous GC identifers: GC02P232834 GC02P233507 GC02P235112 GC02P234608 GC02P234490 GC02P226625


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TRPM8 Gene:
TRPM8 (transient receptor potential cation channel, subfamily M, member 8) is a protein-coding gene. Diseases associated with TRPM8 include aspiration pneumonia, and dentin sensitivity. GO annotations related to this gene include calcium channel activity and protein homodimerization activity. An important paralog of this gene is TRPM2.

UniProtKB/Swiss-Prot: TRPM8_HUMAN, Q7Z2W7
Function: Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by
being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and
modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium,
potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent
gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent
activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves
towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the
activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong
inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is
characterized by outward rectification and poor cationic selectivity. Isoform 2 and isoform 3 negatively regulate
menthol- and cold-induced channel activity by stabilizing the closed state of the channel

summary for TRPM8 Gene:
The melastatin-related receptor family (TRPM) is the largest subfamily of the transient receptor potential
(TRP) superfamily of ion channels. It contains 8 known members, subdivided into 4 groups, which perform a
range of functions including detection of taste and osmolarity, and control of cell proliferation.

Gene Wiki entry for TRPM8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRPM8 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TRPM8 promoter sequence
   Search Chromatin IP Primers for TRPM8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRPM8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37

TRPM8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRPM8 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P234842:  view genomic region     (about GC identifiers)

Start:
234,826,043 bp from pter      End:
234,928,166 bp from pter
Size:
102,124 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRPM8_HUMAN, Q7Z2W7 (See protein sequence)
Recommended Name: Transient receptor potential cation channel subfamily M member 8  
Size: 1104 amino acids; 127685 Da
Subunit: Homotetramer (By similarity). Isoform 2 and isoform 3 interact with the C-terminus of isoform 1 in a
thermosensitive manner with decreased interaction at 21 degrees Celsius compared to 37 degrees Celsius
Miscellaneous: The sensation of coolness triggered by eucalyptol or menthol may be explained by the fact that
menthol and cool temperatures sensations are detected by this protein
Miscellaneous: Its expression in most prostate tumors as well as the presence of an immunogenic epitope suggest
that it may be suitable for the design of peptide vaccination strategies for prostate cancers
Caution: The 192-residue sequence submitted as AAS45276 has been confirmed by the authors of PubMed:22128173 to be
incorrect as translation starts from a downstream methionine
Sequence caution: Sequence=AAH01135.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAS45276.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q3YFM7 Q6QNH9 Q8TAC3 Q8TDX8 Q9BVK1
Alternative splicing: 3 isoforms:  Q7Z2W7-1   Q7Z2W7-2   Q7Z2W7-3   

Explore the universe of human proteins at neXtProt for TRPM8: NX_Q7Z2W7

Explore proteomics data for TRPM8 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn934
  • Modification sites at PhosphoSitePlus

  • See TRPM8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_076985.4  
    ENSEMBL proteins: 
     ENSP00000323926   ENSP00000396745   ENSP00000347956   ENSP00000386771   ENSP00000414198  
     ENSP00000390609   ENSP00000404423  
    Reactome Protein details: Q7Z2W7

    TRPM8 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for TRPM8
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    Novus Biologicals TRPM8 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRPM8

    TRPM8 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TRPM8
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    Novus Biologicals TRPM8 Antibodies
    Abcam antibodies for TRPM8
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    ThermoFisher Antibody for TRPM8
    LSBio Antibodies in human, mouse, rat for TRPM8

    TRPM8 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRPM8
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TRPM8
    Cloud-Clone Corp. CLIAs for TRPM8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TRP: Voltage-gated ion channels / Transient receptor potential cation channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: TRPM8
    Transient Receptor Potential channels

    1 InterPro protein domain:
     IPR005821 Ion_trans_dom

    Graphical View of Domain Structure for InterPro Entry Q7Z2W7

    ProtoNet protein and cluster: Q7Z2W7

    UniProtKB/Swiss-Prot: TRPM8_HUMAN, Q7Z2W7
    Domain: The coiled coil region is required for multimerization
    Similarity: Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM8 sub-subfamily


    TRPM8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRPM8_HUMAN, Q7Z2W7
    Function: Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by
    being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and
    modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium,
    potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent
    gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent
    activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves
    towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the
    activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong
    inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is
    characterized by outward rectification and poor cationic selectivity. Isoform 2 and isoform 3 negatively regulate
    menthol- and cold-induced channel activity by stabilizing the closed state of the channel

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005262calcium channel activity IEA--
    GO:0042803protein homodimerization activity IEA--
         
    TRPM8 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for TRPM8:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella-containin 
     Increased viability after born 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Trpm8):
     behavior/neurological  integument  nervous system 

    TRPM8 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TRPM8: Trpm8tm1Jul Trpm8tm1Apat Trpm8tm1Lex

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRPM8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRPM8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRPM8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRPM8

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRPM8:
    hsa-mir-335-5p (MIRT018725)

    Block miRNA regulation of human, mouse, rat TRPM8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRPM8 (see all 13):
    hsa-miR-3163 hsa-miR-3140-3p hsa-miR-522 hsa-miR-29a hsa-miR-29c hsa-miR-3653 hsa-miR-224* hsa-miR-1284
    SwitchGear 3'UTR luciferase reporter plasmidTRPM8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRPM8
    Predesigned siRNA for gene silencing in human, mouse, rat TRPM8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRPM8

    Clone
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    OriGene clones in human, mouse for TRPM8 (see all 8)
    OriGene ORF clones in mouse, rat for TRPM8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRPM8 (NM_024080)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRPM8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPM8

    Cell Line
    Products:
         
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TRPM8 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPM8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRPM8_HUMAN, Q7Z2W7: Cell membrane; Multi-pass membrane protein. Membrane raft. Endoplasmic reticulum membrane.
    Note=Localizes to membrane rafts but is also located in the cell membrane outside of these regions where channel
    response to cold is enhanced compared to membrane rafts (By similarity). Located in the endoplasmic reticulum in
    prostate cancer cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane5
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005886plasma membrane TAS--
    GO:0009897external side of plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    TRPM8 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TRPM8 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58
    2CREB Pathway
    Intracellular Calcium Signaling0.50
    3Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    4Potassium Channels
    Potassium transporters outward current0.41
    5Development Endothelin 1 EDNRA signaling
    Inflammatory mediator regulation of TRP channels0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TRPM8
        Intracellular Calcium Signaling

    1 Reactome Pathway for TRPM8
        TRP channels


    1 Kegg Pathway  (Kegg details for TRPM8):
        Inflammatory mediator regulation of TRP channels


    TRPM8 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including TRPM8: 
              Neuronal Ion Channels in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TRPM8

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0006816calcium ion transport ----
    GO:0006874cellular calcium ion homeostasis IEA--
    GO:0009266response to temperature stimulus ----
    GO:0009409response to cold IEA--

    TRPM8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for TRPM8
      Browse compounds at ApexBio 

    Compounds for TRPM8 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AMTB hydrochlorideTRPM8 blocker[926023-82-7]
    WS 3TRPM8 agonist; cooling agent[39711-79-0]
    WS 12TRPM8 agonist; cooling agent[68489-09-8]

    3 HMDB Compounds for TRPM8    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Menthol(-)-(1R,3R,4S)-Menthol (see all 21)2216-51-5--
    SodiumSodium (see all 2)7440-23-5--

    1 DrugBank Compound for TRPM8    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Menthol(-)-menthol (see all 5)2216-51-5targetinducer14757700 15190109 7529306 15046718 12654248 15311065 11752352

    Selected IUPHAR Ligands for TRPM8 (TRPM8) (see all 16)    About this table
    LigandTypeActionAffinityPubmed IDs
    menthol
    ActivatorNone4.615306801
    clotrimazole
    Channel blockerNone4.6--
    ACAA
    Channel blockerNone4.6--
    Delta9-tetrahydrocannabinol
    Channel blockerNone4.6--
    NADA
    Channel blockerNone4.6--
    icilin
    ActivatorNone4.6--
    BCTC
    Channel blockerNone4.6--
    anandamide
    Channel blockerNone4.6--
    5-benzyloxytryptamine
    Channel blockerNone4.6--
    capsazepine
    Channel blockerNone4.6--

    3 Novoseek inferred chemical compound relationships for TRPM8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    menthol 95.5 56 19095656 (4), 15931068 (3), 16174775 (3), 15950184 (3) (see all 26)
    capsaicin 60.1 4 12654248 (1), 15363396 (1), 14726308 (1), 17521436 (1)
    calcium 30.8 17 16380208 (4), 19778436 (2), 15670807 (1), 19019830 (1) (see all 7)



    TRPM8 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TRPM8 gene: 
    NM_024080.4  

    Unigene Cluster for TRPM8:

    Transient receptor potential cation channel, subfamily M, member 8
    Hs.366053  [show with all ESTs]
    Unigene Representative Sequence: NM_024080
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000324695(uc002vvh.3 uc010fyj.3 uc010fyk.3) ENST00000444298
    ENST00000355722(uc002vvi.3) ENST00000409625(uc002vvj.3) ENST00000479332
    ENST00000487033 ENST00000490797 ENST00000456930 ENST00000477698 ENST00000475044
    ENST00000477103 ENST00000439148 ENST00000466594 ENST00000433712
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TRPM8 (see all 13):
    hsa-miR-3163 hsa-miR-3140-3p hsa-miR-522 hsa-miR-29a hsa-miR-29c hsa-miR-3653 hsa-miR-224* hsa-miR-1284
    SwitchGear 3'UTR luciferase reporter plasmidTRPM8 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: TRPM8 (NM_024080)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPM8
    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat TRPM8

    Additional mRNA sequence: 

    AB061779.1 AK303811.1 AY328400.1 AY532375.1 AY532376.1 BC001135.2 BC033137.1 BC126342.1 
    BC143819.1 DQ139309.1 FJ895300.1 

    5 DOTS entries:

    DT.40241919  DT.40284818  DT.100018567  DT.120939787  DT.91691062 

    Selected AceView cDNA sequences (see all 40):

    BC033137 AA622057 BC001135 AB061779 BF477681 AV650700 AY328400 BX090897 
    AY532376 AI670079 AY532375 BE274448 AI272941 BX283818 BU532384 AI420227 
    NM_024080 AA370110 BE390627 AY090109 BF939313 AW451174 AW615479 AA313170 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TRPM8 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
    SP1:              -           -                       -     -                       -                                         -                                 
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                          -                                                                                                                                 
    SP5:                                                                                                                                                            

    ExUns: 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28
    SP1:              -                                       
    SP2:                                                      
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for TRPM8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRPM8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAAAACCAC
    TRPM8 Expression
    About this image

    TRPM8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRPM8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.366053

    UniProtKB/Swiss-Prot: TRPM8_HUMAN, Q7Z2W7
    Tissue specificity: Expressed in prostate. Also expressed in prostate tumors and in non-prostatic primary tumors
    such as colon, lung, breast and skin tumors

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TRPM8 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trpm81 , 5 transient receptor potential cation channel, subfamily more1, 5 88.16(n)1
    93.75(a)1
      1 (44.57 cM)5
    1713821  NM_134252.31  NP_599013.11 
     882776615 
    chicken
    (Gallus gallus)
    Aves TRPM81 transient receptor potential cation channel, subfamily more 77.26(n)
    81.37(a)
      424025  NM_001007082.1  NP_001007083.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRPM86
    transient receptor potential cation channel, subfa...
    82(a)
    1 ↔ 1
    1(119299304-119365176)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia trpm81 transient receptor potential cation channel, subfamily more 71.94(n)
    77.31(a)
      100302008  NM_001161633.1  NP_001155105.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta trpm6
    --
    15(a)
    1 → many
    2R(11150309-11180386)
    worm
    (Caenorhabditis elegans)
    Secernentea gtl-26
    gtl-16
    (see all 3)
    Protein GTL-1 (gtl-1) mRNA, complete cds
    (see all 3)
    20(a)
    17(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    IV(11273483-11281924) WBGene00001796
    IV(11248902-11259465) WBGene00001795


    ENSEMBL Gene Tree for TRPM8 (if available)
    TreeFam Gene Tree for TRPM8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRPM8 gene
    TRPM22  TRPM52  TRPM72  TRPM62  TRPM12  TRPM32  TRPM42  
    6 SIMAP similar genes for TRPM8 using alignment to 6 protein entries:     TRPM8_HUMAN (see all proteins):
    TRPM2    MLSN2    TRPM3    TRPM5    TRPM6    TRPM4

    TRPM8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRPM8 (see all 2973)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1444019581,2
    Cuntested1234839335(+) TCAAGA/C/TAAATT 2 E A mis10--------
    rs1403820671,2
    Cuntested1234854620(+) CTGTCA/GAAGCA 2 K E mis10--------
    rs102032911,2
    C,F,A,H--234824050(+) AAAAAC/ACAAAA 1 -- us2k110Minor allele frequency- A:0.08NS EA NA CSA WA 842
    rs1826174831,2
    --234824084(+) TGAATA/TGGGCA 1 -- us2k10--------
    rs1390384751,2
    --234824098(+) TGTTGC/TGTCTT 1 -- us2k10--------
    rs1882349961,2
    C--234824135(+) TATATG/TTACAC 1 -- us2k10--------
    rs1498902821,2
    C--234824174(+) CTCTCA/GCTCCC 1 -- us2k10--------
    rs1927566151,2
    C--234824330(+) GAGATA/GGAACA 1 -- us2k10--------
    rs1844631991,2
    --234824343(+) AGACTG/TGCTTA 1 -- us2k10--------
    rs1406442331,2
    C--234824543(+) GATTCG/TCATGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TRPM8 (234826043 - 234928166 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TRPM8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876024CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606678    OMIM disorders: --

    Selected diseases for TRPM8 (see all 23):    
    About MalaCards
    aspiration pneumonia    dentin sensitivity    migraine without aura    pain agnosia
    agnosia    diabetic neuropathy    lichen sclerosus    migraine
    pneumonia    neuroendocrine tumor    allergic rhinitis    rhinitis
    vascular disease    neuropathy    prostate cancer    prostatitis
    neuroblastoma    melanoma    adenocarcinoma    pancreatitis

    2 diseases from the University of Copenhagen DISEASES database for TRPM8:
    Pain agnosia     Prostate cancer

    TRPM8 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for TRPM8 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 34.5 7 16174775 (2), 17517434 (2), 12858355 (1), 16949669 (1)
    tumors 0 4 12858355 (2), 16949669 (1)

    Genetic Association Database (GAD): TRPM8
    Human Genome Epidemiology (HuGE) Navigator: TRPM8 (3 documents)

    Export disorders for TRPM8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRPM8 gene, integrated from 10 sources (see all 107):
    (articles sorted by number of sources associating them with TRPM8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel role of cold/menthol-sensitive transient receptor potential melastatine family member 8 (TRPM8) in the activation of store- operated channels in LNCaP human prostate cancer epithelial cells. (PubMed id 16174775)1, 2, 9 Thebault S.... Prevarskaya N. (J. Biol. Chem. 2005)
    2. Identification of an HLA-A*0201-restricted T-cell epitope derived from the prostate cancer-associated protein trp-p8. (PubMed id 12858355)1, 2, 9 Kiessling A.... Rieber E.P. (Prostate 2003)
    3. Trafficking and assembly of the cold-sensitive TRPM8 channel. (PubMed id 17065148)1, 2, 9 Erler I....Niemeyer B.A. (J. Biol. Chem. 2006)
    4. Regulation of activity of transient receptor potential melastatin 8 (TRPM8) channel by its short isoforms. (PubMed id 22128173)1, 2 Bidaux G....Prevarskaya N. (J. Biol. Chem. 2012)
    5. Genome-wide association study reveals three susceptibility loci for common migraine in the general population. (PubMed id 21666692)1, 4 Chasman D.I....Kurth T. (Nat. Genet. 2011)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. (PubMed id 16382100)1, 3 Clapham D.E....Schultz G. (Pharmacol. Rev. 2005)
    8. The principle of temperature-dependent gating in cold- and heat- sensitive TRP channels. (PubMed id 15306801)1, 2 Voets T....Nilius B. (Nature 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins. (PubMed id 11325849)1, 2 Tsavaler L.... Laus R. (Cancer Res. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79054 HGNC: 17961 AceView: TRPM8 Ensembl:ENSG00000144481 euGenes: HUgn79054
    ECgene: TRPM8 Kegg: 79054 H-InvDB: TRPM8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRPM8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRPM8 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRPM8 gene:
    Search GeneIP for patents involving TRPM8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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