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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TRPM7 Gene

protein-coding GIFtS: 63
GCID: GC15M050852

transient receptor potential cation channel, subfamily M,...

Explore 18 diseases affiliated with
TRPM7 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transient Receptor Potential Cation Channel, Subfamily M, Member 7¹ ²		EC 2.7.11.1³ ⁸
LTRPC7¹ ² ³ ⁵		CHAK² ⁵
CHAK1¹ ² ³		ALSPDC²
TRP-PLIK¹ ²		LTRPC Ion Channel Family Member 7²
Channel-Kinase 1² ³		Transient Receptor Potential Cation Channel Subfamily M Member 7²
Long Transient Receptor Potential Channel 7² ³		Transient Receptor Potential-Phospholipase C-Interacting Kinase²
LTrpC-7² ³		LTrpC7³

External Ids:	HGNC: 17994¹	Entrez Gene: 54822²	Ensembl: ENSG00000092439⁷	OMIM: 605692⁵	UniProtKB: Q96QT4³

Export aliases for TRPM7 gene to outside databases

Previous GC identifers: GC15M046409 GC15M043898 GC15M048431 GC15M048568 GC15M048639 GC15M027680

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRPM7:

The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is

essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate

magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia

complex of Guam.(provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: TRPM7_HUMAN, Q96QT4

Function: Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and

magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The

kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma

membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)

Gene Wiki entry for TRPM7

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TRPM7 gene promoter:
Sox5 HNF-3beta AP-2gamma Evi-1 FOXL1 IRF-7A AP-2beta AP-2alpha ATF6 AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRPM7 promoter sequence

Search SABiosciences Chromatin IP Primers for TRPM7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRPM7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21 Ensembl cytogenetic band: 15q21.2 HGNC cytogenetic band: 15q21

TRPM7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRPM7 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M050852: view genomic region (about GC identifiers)

Start:	50,844,670 bp from pter	End:	50,979,012 bp from pter
Size:	134,343 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TRPM7_HUMAN, Q96QT4 (See protein sequence)

Recommended Name: Transient receptor potential cation channel subfamily M member 7

Size: 1865 amino acids; 212697 Da

Cofactor: Binds 1 zinc ion per subunit (By similarity)

Subunit: Homodimer. Interacts with PLCB1 (By similarity). Forms heterodimers with TRPM6

Subcellular location: Membrane; Multi-pass membrane protein (Probable)

Sequence caution: Sequence=BAC11462.1; Type=Erroneous initiation; Sequence=BAD18773.1; Type=Erroneous initiation;

Secondary accessions: Q6ZMF5 Q86VJ4 Q8NBW2 Q9BXB2 Q9NXQ2

Explore the universe of human proteins at neXtProt for TRPM7: NX_Q96QT4

Post-translational modifications:

Autophosphorylated (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96QT4

4/25 DME Specific Peptides for TRPM7 (Q96QT4) (see all 25)

WSVEKHT

PWGVIEN

AGRLIYC

SMSSWSQ

TRPM7 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_060142.3

ENSEMBL proteins:

ENSP00000454066 ENSP00000453277 ENSP00000320239 ENSP00000452873

Human Recombinant Protein Products for TRPM7:

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	Novus Biologicals TRPM7 Proteins
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TRPM7

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001726	ruffle	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

TRPM7 for ontologies About GeneDecksing

TRPM7 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of TRPM7
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	OriGene Antibodies (see all 2): TRPM7 OriGene Custom Antibody Services for TRPM7
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	Novus Biologicals TRPM7 Antibodies
	Abcam antibodies for TRPM7
	Uscn Antibodies for TRPM7
	ThermoFisher Antibodies for TRPM7

Assay Products for TRPM7:

	Browse Kits and Assays available from EMD Millipore
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	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TRPM7
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TRPM7

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TRPM7 for domains About GeneDecksing

3 InterPro domains/families:

IPR011009 Kinase-like_dom

IPR005821 Ion_trans_dom

IPR004166 MHCK_EF2_kinase

Graphical View of Domain Structure for InterPro Entry Q96QT4

ProtoNet protein and cluster: Q96QT4

UniProtKB/Swiss-Prot: TRPM7_HUMAN, Q96QT4

Similarity: In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family.

ALPK subfamily

Similarity: In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM7

sub-subfamily

Similarity: Contains 1 alpha-type protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TRPM7_HUMAN, Q96QT4

Function: Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and

magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The

kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma

membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme Number (IUBMB): EC 2.7.11.1¹ ²

Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--
GO:0004674	protein serine/threonine kinase activity	IEA	--
GO:0004872	receptor activity	--	--
GO:0005216	ion channel activity	--	--
GO:0005262	calcium channel activity	IEA	--

TRPM7 for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for TRPM7:

Decreased substrate adherent c

Decreased viability of wild-ty

Increased cell death in HCT116

4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Trpm7):

cellular

hematopoietic system

immune system

mortality/aging

TRPM7 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Trpm7^tm1.1Clph for TRPM7

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TRPM7

miRNA Products:		OriGene 3'-UTR Clone: TRPM7 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRPM7
		8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate TRPM7 (see all 88):
		hsa-miR-579 hsa-miR-3607-3p hsa-miR-300 hsa-miR-4272 hsa-miR-30d hsa-miR-632 hsa-miR-578 hsa-miR-138-2*

		SwitchGear 3'UTR luciferase reporter plasmid: TRPM7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRPM7 (see all 4) OriGene shRNA RFP: TRPM7 OriGene siRNA: TRPM7
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		Sirion Biotech Custom design and validation of potent shRNA sequences against TRPM7

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for TRPM7
			Sirion Biotech Customized adenovirus for overexpression of TRPM7 Sirion Biotech Customized adenovirus for potent knockdown of TRPM7

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRPM7 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRPM7 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TRPM7 (NM_017672)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRPM7
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRPM7

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TRPM7
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		Sirion Biotech Customized stable knockdown cell line services for TRPM7 Sirion Biotech Customized inducible knockdown cell line services for TRPM7

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPM7

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Calcium channels

Calcium channels

1.00

Mineral absorption

Mineral absorption

1.00

CREB Pathway

Intracellular Calcium Signaling

0.50

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for TRPM7

Calcium channels

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TRPM7

Intracellular Calcium Signaling

1 Kegg Pathway (Kegg details for TRPM7):

Mineral absorption

TRPM7 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TRPM7

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/16 Interacting proteins for TRPM7 (Q96QT4^{2, 3} ENSP00000320239⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 16)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MYH10	P35580²^,³, ENSP00000269243⁴	MINT-6699391 I2D: score=1 STRING: ENSP00000269243
MYH9	P35579²^,³, ENSP00000216181⁴	MINT-6699369 I2D: score=3 STRING: ENSP00000216181
MYH14	Q7Z406²^,³, ENSP00000407879⁴	MINT-6699418 I2D: score=1 STRING: ENSP00000407879
MBP	P02686³, ENSP00000348273⁴	I2D: score=2 STRING: ENSP00000348273
PLCB1	Q9NQ66³, ENSP00000338185⁴	I2D: score=2 STRING: ENSP00000338185

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein phosphorylation	--	--
GO:0006816	calcium ion transport	--	--
GO:0008219	cell death	IEA	--
GO:0016340	calcium-dependent cell-matrix adhesion	IEA	--
GO:0031032	actomyosin structure organization	IEA	--

TRPM7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TRPM7 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TRPM7

4 HMDB Compounds for TRPM7 About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Calcium	Ca (see all 2)	7440-70-2	--
Magnesium	Magnesium (see all 2)	7439-95-4	--

3 DrugBank Compounds for TRPM7 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
1,4-Dithiothreitol	--	--	target	--	10592235
Adenosine-5'-Diphosphate	--	20398-34-9	target	--	10592235
Phosphoaminophosphonic Acid-Adenylate Ester	--	--	target	--	10592235

3 Novoseek chemical compound relationships for TRPM7 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
magnesium	57.8	21	17599911 (5), 16051700 (4), 18192217 (3), 16258415 (3) (see all 7)
threonine	20.2	5	17217065 (1), 11941371 (1)
serine	4.6	5	17217065 (1), 11941371 (1)

Search CenterWatch for drugs/clinical trials and news about TRPM7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TRPM7 gene:

NM_017672.4

Unigene Cluster for TRPM7:

Transient receptor potential cation channel, subfamily M, member 7

Hs.512894 [show with all ESTs]

Unigene Representative Sequence: NM_017672

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000561267 ENST00000560955(uc001zyr.3) ENST00000313478(uc001zyt.4 uc010bew.2)

ENST00000561443 ENST00000560516 ENST00000558444 ENST00000560849 ENST00000560284

ENST00000560638(uc001zyu.3)

miRNA Products:		OriGene 3'-UTR Clone: TRPM7 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRPM7
		8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate TRPM7 (see all 88):
		hsa-miR-579 hsa-miR-3607-3p hsa-miR-300 hsa-miR-4272 hsa-miR-30d hsa-miR-632 hsa-miR-578 hsa-miR-138-2*

		SwitchGear 3'UTR luciferase reporter plasmid: TRPM7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRPM7 (see all 4) OriGene shRNA RFP: TRPM7 OriGene siRNA: TRPM7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRPM7
		Sirion Biotech Custom design and validation of potent shRNA sequences against TRPM7

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRPM7 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRPM7 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TRPM7 (NM_017672)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRPM7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRPM7

Additional cDNA sequence:

AF346629.2 AK000124.1 AK075193.1 AK098584.1 AK172800.1 BC028843.1 BC051024.1 BC128987.1

BC128988.1

12 DOTS entries:

DT.112493 DT.91748369 DT.40111505 DT.95200599 DT.70104997 DT.100021316 DT.112492 DT.75173963

DT.75131160 DT.95096970 DT.95358754 DT.104153

24/175 AceView cDNA sequences (see all 175):

NM_017672 AI738509 BX498148 AA262742 BQ428396 CA430562 AF346629 H92595

BE857499 AI160721 BM680261 BC051024 AI610861 AA235623 BX495468 CK724921

AJ289816 AA261876 AK098584 BU688027 BX952858 AA261842 BU153353 BQ002389

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TRPM7 (see all 6) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16a	·	16b	^	17	^	18a	·	18b	^	19	^	20	^	21	^	22	^	23	^	24	^
SP1:
SP2:
SP3:
SP4:																																							-
SP5:

ExUns:	25	^	26	^	27	^	28	^	29	^	30	^	31a	·	31b	^	32	^	33	^	34	^	35	^	36a	·	36b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for TRPM7

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRPM7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATGCTGTTT

About this image

TRPM7 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Loop of Henle

Loop of Henle Cells

Kidney

Heart

Left Ventricle

Heart

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TRPM7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRPM7

SOURCE GeneReport for Unigene cluster: Hs.512894

SABiosciences Custom PCR Arrays for TRPM7

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRPM7 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TRPM7
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRPM7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRPM7

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPM7

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TRPM7 gene from 6/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TRPM7¹	transient receptor potential cation channel, subfamily more	82.3(n) 87.9(a)		427502 NM_001177555.1 NP_001171026.1
lizard (Anolis carolinensis)	Reptilia	TRPM7⁶	--	85(a)	1 ↔ 1	GL343747.1(104352-135938)
African clawed frog (Xenopus laevis)	Amphibia	48012739²	--	78.97(n)		48012739
zebrafish (Danio rerio)	Actinopterygii	57053259²	--	75.28(n)		322919 57053259
fruit fly (Drosophila melanogaster)	Insecta	CG30079³	--	43(a) (best of 2)		--
worm (Caenorhabditis elegans)	Secernentea	gtl-2⁶ gon-2⁶ (see all 4)	Transient receptor potential channel (see all 4)	29(a) 25(a) (see all 4)	possible ortholog possible ortholog (see all 4)	IV(11273461-11281902) I(8549507-8570951)

ENSEMBL Gene Tree for TRPM7 (if available)
TreeFam Gene Tree for TRPM7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TRPM7 gene

TRPM2² TRPM5² TRPM8² TRPM1² TRPM6² TRPM4² TRPM3²

5 SIMAP similar genes for TRPM7 using alignment to 3 protein entries: TRPM7_HUMAN (see all proteins):

MLSN2 TRPM3 TRPM6 TRPM1 TRPM4

TRPM7 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs58959948^1,2	C,F	--	27680287(+)	`GCAAGC/TAAGGT`	1	--	ut3¹		4		WA CSA	124
rs76393895^1,2	C,F	--	27680412(+)	`GTGGGG/AAAAGT`	1	--	ut3¹		1		WA	118
rs35806905^1,2		--	27680705(+)	`TCTCCC/TGCCTC`	1	--	ut3¹		0	--	--	--	--
rs73408905^1,2	C	--	27681251(+)	`CACTTT/CGGGAA`	1	--	ut3¹		3		WA	122
rs2414071^1,2	C,A	--	27681372(-)	`AGCCAC/TCATGC`	1	--	ut3¹		0	--	--	--	--
rs73408906^1,2	C,F	--	27681430(+)	`TTGAGA/GTCAGG`	1	--	ut3¹		3		WA CSA	6
rs11070792^1,2		--	27681479(+)	`CTCTAC/TGAAAA`	1	--	ut3¹		0	--	--	--	--
rs11070793^1,2	F	--	27681494(+)	`AAAAAT/ACAGCC`	1	--	ut3¹		1		WA	118
rs11070794^1,2		--	27681523(+)	`CTGTAA/GTCTCA`	1	--	ut3¹		0	--	--	--	--
rs2414070^1,2		--	27681605(-)	`agtacA/Ggtggc`	1	--	ut3¹		2		NA	4

HapMap Linkage Disequilibrium report for TRPM7 (50844670 - 50979012 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TRPM7
2 CNVs: 53349 29644
Human Gene Mutation Database (HGMD): TRPM7

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TRPM7 for disorders           About GeneDecksing

OMIM gene information: 605692
OMIM disorders: 105500
UniProtKB/Swiss-Prot: TRPM7_HUMAN, Q96QT4

Defects in TRPM7 are a cause of susceptibility to amyotrophic lateral sclerosis-parkinsonism/dementia complex

type 1 (ALS-PDC1) [MIM:105500]; also called amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam or

Guam disease. Amyotrophic lateral sclerosis-parkinsonism/dementia complex type 1 is a neurodegenerative disorder

characterized by chronic, progressive and uniformly fatal amyotrophic lateral sclerosis and parkinsonism-dementia.

Both diseases are known to occur in the same kindred, the same sibship and even the same individual

18 diseases for TRPM7: About MalaCards

amyotrophic lateral sclerosis amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 lateral sclerosis dementia

hypomagnesemia with secondary hypocalcemia type 2 diabetes mellitus hypomagnesemia hypocalcemia

atrial fibrillation diabetes mellitus brain ischemia ischemia

gastric cancer breast cancer hypertension carcinoma

pancreatitis neuronitis

Human Genome Epidemiology (HuGE) Navigator: TRPM7 (5 documents)

Export disorders for TRPM7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TRPM7 gene, integrated from 9 sources (see all 92):
(articles sorted by number of sources associating them with TRPM7)

Utopia: connect your pdf to the dynamic
world of online information

LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability. (PubMed id 11385574)^{1, 2, 3, 9} Nadler M.J.S....Fleig A. (2001)
Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7. (PubMed id 12887921)^{1, 2, 9} Schmitz C.... Scharenberg A.M. (2003)
A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian neurodegenerative disorders. (PubMed id 16051700)^{1, 2, 9} Hermosura M.C.... Garruto R.M. (2005)
International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. (PubMed id 16382100)^{1, 3} Clapham D.E....Schultz G. (2005)
Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia. (PubMed id 14976260)^{1, 2} Chubanov V.... Gudermann T. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Characterization of the protein kinase activity of TRPM7/ChaK1, a protein kinase fused to the transient receptor potential ion channel. (PubMed id 14594813)^{1, 2} Ryazanova L.V.... Ryazanov A.G. (2004)
Phosphorylation of annexin I by TRPM7 channel-kinase. (PubMed id 15485879)^{1, 2} Dorovkov M.V. and Ryazanov A.G. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
TRP-PLIK, a bifunctional protein with kinase and ion channel activities. (PubMed id 11161216)^{1, 3} Runnels L.W....Clapham D.E. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 54822	HGNC: 17994	AceView: TRPM7	Ensembl:ENSG00000092439	euGenes: HUgn54822
ECgene: TRPM7	Kegg: 54822	H-InvDB: TRPM7

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TRPM7	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TRPM7 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TRPM7 gene:
Search GeneIP for patents involving TRPM7

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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