Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TRPM7 Gene

protein-coding   GIFtS: 66
GCID: GC15M050852

Transient Receptor Potential Cation Channel, Subfamily M,...

  See TRPM7-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Transient Receptor Potential Cation Channel, Subfamily M, Member 71 2     ALSPDC2 5
LTRPC72 3 5     CHAK2 5
Channel-Kinase 12 3     TRP-PLIK2
Long Transient Receptor Potential Channel 72 3     LTRPC Ion Channel Family Member 72
CHAK12 3     Transient Receptor Potential Cation Channel Subfamily M Member 72
LTrpC-72 3     Transient Receptor Potential-Phospholipase C-Interacting Kinase2
EC 2.7.11.13 8     LTrpC73

External Ids:    HGNC: 179941   Entrez Gene: 548222   Ensembl: ENSG000000924397   OMIM: 6056925   UniProtKB: Q96QT43   

Export aliases for TRPM7 gene to outside databases

Previous GC identifers: GC15M046409 GC15M043898 GC15M048431 GC15M048568 GC15M048639 GC15M027680


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TRPM7 Gene:
The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity
is essential for the ion channel function, which serves to increase intracellular calcium levels and to help
regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral
sclerosis-parkinsonism/dementia complex of Guam.(provided by RefSeq, May 2010)

GeneCards Summary for TRPM7 Gene:
TRPM7 (transient receptor potential cation channel, subfamily M, member 7) is a protein-coding gene. Diseases associated with TRPM7 include amyotrophic lateral sclerosis-parkinsonism/dementia complex, and hypomagnesemia with secondary hypocalcemia. GO annotations related to this gene include protein serine/threonine kinase activity and calcium channel activity. An important paralog of this gene is TRPM2.

UniProtKB/Swiss-Prot: TRPM7_HUMAN, Q96QT4
Function: Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium
and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell
death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is
essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane
divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)

Gene Wiki entry for TRPM7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRPM7 gene promoter:
         Sox5   HNF-3beta   AP-2gamma   Evi-1   FOXL1   IRF-7A   AP-2beta   AP-2alpha   ATF6   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRPM7 promoter sequence
   Search Chromatin IP Primers for TRPM7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRPM7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21   Ensembl cytogenetic band:  15q21.2   HGNC cytogenetic band: 15q21

TRPM7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRPM7 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M050852:  view genomic region     (about GC identifiers)

Start:
50,844,670 bp from pter      End:
50,979,012 bp from pter
Size:
134,343 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TRPM7_HUMAN, Q96QT4 (See protein sequence)
Recommended Name: Transient receptor potential cation channel subfamily M member 7  
Size: 1865 amino acids; 212697 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Homodimer. Interacts with PLCB1 (By similarity). Forms heterodimers with TRPM6
Sequence caution: Sequence=BAC11462.1; Type=Erroneous initiation; Sequence=BAD18773.1; Type=Erroneous initiation;
Secondary accessions: Q6ZMF5 Q86VJ4 Q8NBW2 Q9BXB2 Q9NXQ2

Explore the universe of human proteins at neXtProt for TRPM7: NX_Q96QT4

Explore proteomics data for TRPM7 at MOPED

Post-translational modifications: 

  • Autophosphorylated (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TRPM7 (Q96QT4) (see all 25)
     WSVEKHT  PWGVIEN  AGRLIYC  SMSSWSQ 


    See TRPM7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060142.3  
    ENSEMBL proteins: 
     ENSP00000454066   ENSP00000453277   ENSP00000320239   ENSP00000452873  
    Reactome Protein details: Q96QT4

    TRPM7 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TRPM7
    GenScript Custom Purified and Recombinant Proteins Services for TRPM7
    Novus Biologicals TRPM7 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRPM7

     
    Search eBioscience for Proteins for TRPM7 

    TRPM7 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TRPM7
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TRPM7
    OriGene Custom Antibody Services for TRPM7
    Novus Biologicals TRPM7 Antibodies
    Abcam antibodies for TRPM7
    Cloud-Clone Corp. Antibodies for TRPM7
    ThermoFisher Antibodies for TRPM7
    LSBio Antibodies in human, mouse, rat for TRPM7

    TRPM7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TRPM7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRPM7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TRPM7
    Cloud-Clone Corp. CLIAs for TRPM7
    Search eBioscience for ELISAs for TRPM7 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    TRP: Voltage-gated ion channels / Transient receptor potential cation channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: TRPM7
    ChaK subfamily
    Transient Receptor Potential channels

    3 InterPro protein domains:
     IPR011009 Kinase-like_dom
     IPR005821 Ion_trans_dom
     IPR004166 MHCK_EF2_kinase

    Graphical View of Domain Structure for InterPro Entry Q96QT4

    ProtoNet protein and cluster: Q96QT4

    UniProtKB/Swiss-Prot: TRPM7_HUMAN, Q96QT4
    Similarity: In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase
    family. ALPK subfamily
    Similarity: In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM7
    sub-subfamily
    Similarity: Contains 1 alpha-type protein kinase domain


    Find genes that share domains with TRPM7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRPM7_HUMAN, Q96QT4
    Function: Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium
    and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell
    death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is
    essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane
    divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Number (IUBMB): EC 2.7.11.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0005216ion channel activity ----
    GO:0005262calcium channel activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with TRPM7           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for TRPM7:
     Decreased substrate adherent c  Decreased viability of wild-ty  Increased cell death in HCT116 

         11 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Trpm7):
     behavior/neurological  cellular  digestive/alimentary  embryogenesis  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  nervous system 
     renal/urinary system 

    Find genes that share phenotypes with TRPM7           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Trpm7tm1.1Clph for TRPM7

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRPM7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRPM7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRPM7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRPM7

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRPM7:
    hsa-mir-10a-5p (MIRT047669), hsa-mir-9-5p (MIRT021383), hsa-mir-21-5p (MIRT030789)

    Block miRNA regulation of human, mouse, rat TRPM7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRPM7 (see all 88):
    hsa-miR-579 hsa-miR-3607-3p hsa-miR-300 hsa-miR-4272 hsa-miR-30d hsa-miR-632 hsa-miR-578 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidTRPM7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRPM7
    Predesigned siRNA for gene silencing in human, mouse, rat TRPM7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRPM7

    Clone
    Products:
         
    OriGene clones in human, mouse for TRPM7 (see all 7)
    OriGene ORF clones in mouse, rat for TRPM7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRPM7 (NM_017672)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRPM7
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRPM7
    Addgene plasmids for TRPM7 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TRPM7
    Browse ESI BIO Cell Lines and PureStem Progenitors for TRPM7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPM7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TRPM7_HUMAN, Q96QT4: Membrane; Multi-pass membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular2
    cytoskeleton1
    cytosol1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IEA--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TRPM7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TRPM7 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58
    2CREB Pathway
    Intracellular Calcium Signaling0.50
    3Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    4TRP channels
    TRP channels
    5Mineral absorption
    Mineral absorption


    Find genes that share SuperPaths with TRPM7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TRPM7
        Intracellular Calcium Signaling

    1 Reactome Pathway for TRPM7
        TRP channels


    1 Kegg Pathway  (Kegg details for TRPM7):
        Mineral absorption

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRPM7
    Interactions:

        GeneGlobe Interaction Network for TRPM7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for TRPM7 (Q96QT42, 3 ENSP000003202394) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYH10P355802, 3, ENSP000002692434MINT-6699391 I2D: score=1 STRING: ENSP00000269243
    MYH9P355792, 3, ENSP000002161814MINT-6699369 I2D: score=3 STRING: ENSP00000216181
    MYH14Q7Z4062, 3, ENSP000004078794MINT-6699418 I2D: score=1 STRING: ENSP00000407879
    MBPP026863, ENSP000003482734I2D: score=2 STRING: ENSP00000348273
    PLCB1Q9NQ663, ENSP000003381854I2D: score=2 STRING: ENSP00000338185
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0006811ion transport ----
    GO:0006816calcium ion transport ----
    GO:0008219cell death ----
    GO:0016340calcium-dependent cell-matrix adhesion IEA--

    Find genes that share ontologies with TRPM7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRPM7

    4 HMDB Compounds for TRPM7    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--

    3 DrugBank Compounds for TRPM7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1,4-Dithiothreitol-- --target--10592235
    Adenosine-5'-Diphosphate-- 20398-34-9target--10592235
    Phosphoaminophosphonic Acid-Adenylate Ester-- --target--10592235

    8 IUPHAR Ligands for TRPM7 (TRPM7)    About this table
    LigandTypeActionAffinityPubmed IDs
    cAMP
    ActivatorNone--
    carvacrol
    Channel blockerNone--
    ATP
    ActivatorPotentiation--
    spermine
    Channel blockerNone--
    La3+
    Channel blockerNone--
    2-APB
    Channel blockerNone--
    H+ (extracellular)
    ActivatorPotentiation--
    Mg2+
    Channel blockerNone--

    3 Novoseek inferred chemical compound relationships for TRPM7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    magnesium 57.8 21 17599911 (5), 16051700 (4), 18192217 (3), 16258415 (3) (see all 7)
    threonine 20.2 5 17217065 (1), 11941371 (1)
    serine 4.6 5 17217065 (1), 11941371 (1)



    Find genes that share compounds with TRPM7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TRPM7 gene: 
    NM_017672.4  

    Unigene Cluster for TRPM7:

    Transient receptor potential cation channel, subfamily M, member 7
    Hs.512894  [show with all ESTs]
    Unigene Representative Sequence: NM_017672
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000561267 ENST00000560955(uc001zyr.3) ENST00000313478(uc001zyt.4 uc010bew.2)
    ENST00000561443 ENST00000560516 ENST00000558444 ENST00000560849 ENST00000560284
    ENST00000560638(uc001zyu.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TRPM7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRPM7 (see all 88):
    hsa-miR-579 hsa-miR-3607-3p hsa-miR-300 hsa-miR-4272 hsa-miR-30d hsa-miR-632 hsa-miR-578 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidTRPM7 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TRPM7
    Predesigned siRNA for gene silencing in human, mouse, rat TRPM7
    Clone
    Products:
         
    OriGene clones in human, mouse for TRPM7 (see all 7)
    OriGene ORF clones in mouse, rat for TRPM7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRPM7 (NM_017672)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRPM7
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRPM7
    Addgene plasmids for TRPM7 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TRPM7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRPM7
      QuantiTect SYBR Green Assays in human, mouse, rat TRPM7
      QuantiFast Probe-based Assays in human, mouse, rat TRPM7

    Additional mRNA sequence: 

    AF346629.2 AK000124.1 AK075193.1 AK098584.1 AK172800.1 BC028843.1 BC051024.1 BC128987.1 
    BC128988.1 

    12 DOTS entries:

    DT.112493  DT.91748369  DT.40111505  DT.95200599  DT.70104997  DT.100021316  DT.112492  DT.75173963 
    DT.75131160  DT.95096970  DT.95358754  DT.104153 

    Selected AceView cDNA sequences (see all 175):

    AF346629 BP370310 CB162659 BM680261 BU153353 AA261876 CA430562 BC051024 
    BQ432223 AA262742 BU688027 AK098584 W04694 AI738509 AA261803 NM_017672 
    AA642331 BQ428396 AA261842 AL043166 AK000124 BQ002389 AA235623 BX498148 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TRPM7 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                    -                                       
    SP5:                                                                                                                                                            

    ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b ^ 32 ^ 33 ^ 34 ^ 35 ^ 36a · 36b
    SP1:                                                                                    
    SP2:                                                                                    
    SP3:                                                                                    
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for TRPM7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TRPM7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGCTGTTT
    TRPM7 Expression
    About this image


    TRPM7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Epithelial Cells
             Loop of Henle Cells Loop of Henle
     
     Kidney (Urinary System)
             Loop of Henle Cells Loop of Henle
    TRPM7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRPM7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.512894
        Custom PCR Arrays for TRPM7
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TRPM7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRPM7
    QuantiTect SYBR Green Assays in human, mouse, rat TRPM7
    QuantiFast Probe-based Assays in human, mouse, rat TRPM7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPM7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for TRPM7 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trpm71 , 5 transient receptor potential cation channel, subfamily more1, 5 90.83(n)1
    94.36(a)1
      2 (61.76 cM)5
    588001  NM_001164325.11  NP_001157797.11 
     1267915655 
    chicken
    (Gallus gallus)
    Aves TRPM71 transient receptor potential cation channel, subfamily more 82.3(n)
    87.9(a)
      427502  NM_001177555.1  NP_001171026.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRPM76
    transient receptor potential cation channel, subfa...
    85(a)
    1 ↔ 1
    GL343747.1(104352-154466)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480127392   -- 78.97(n)    48012739 
    zebrafish
    (Danio rerio)
    Actinopterygii 570532592   -- 75.28(n)   322919  57053259 


    ENSEMBL Gene Tree for TRPM7 (if available)
    TreeFam Gene Tree for TRPM7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TRPM7 gene
    TRPM22  TRPM52  TRPM82  TRPM62  TRPM12  TRPM32  TRPM42  
    4 SIMAP similar genes for TRPM7 using alignment to 3 protein entries:     TRPM7_HUMAN (see all proteins):
    MLSN2    TRPM3    TRPM6    TRPM1

    Find genes that share paralogs with TRPM7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TRPM7 (see all 3196)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0424004
    A gastric adenocarcinoma sample4--see VAR_0424002 M V mis40--------
    VAR_0423964
    An ovarian serous carcinoma sample4--see VAR_0423962 S C mis40--------
    VAR_0423994
    A breast infiltrating ductal carcinoma sample4--see VAR_0423992 T S mis40--------
    rs80429191,2,,4
    C,F,A,Hother130945207(+) AGTCAG/ATAAAT 2 /T /I mis1 ese327Minor allele frequency- A:0.09PA EA NA NS EU 3657
    rs743349681,2
    C--27681811(+) ACACT-/CCAGCC 1 -- ut310--------
    rs344616331,2
    C--27682963(+) GTCTC-/AAAAAA 1 -- ut310--------
    rs2007245881,2
    --27695013(+) TTCTT-/TATATAT 1 -- int10--------
    rs593233351,2
    C--27695033(+) GTTTA-/ATCT  
      TTAT
    /T
    ACTTG
    1 -- int10--------
    rs30778721,2
    C--27706872(-) GTCTC-/A/AAA 
            
    AAAAA
    2 -- int1 cds1 trp32NA CSA 4
    rs1461803711,2
    C--27711691(+) TTAAA-/TTAAG 
            
    TTAAT
    1 -- int10--------

    HapMap Linkage Disequilibrium report for TRPM7 (50844670 - 50979012 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TRPM7 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749686CNV Deletion23290073
    esv2664477CNV Deletion23128226
    esv2674857CNV Deletion23128226
    esv2749687CNV Deletion23290073
    esv1392000CNV Insertion17803354
    nsv1532CNV Insertion18451855
    nsv524596CNV Loss19592680
    nsv904211CNV Loss21882294
    nsv524613CNV Loss19592680
    dgv317n27CNV Gain19166990

    Human Gene Mutation Database (HGMD): TRPM7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRPM7
    DNA2.0 Custom Variant and Variant Library Synthesis for TRPM7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605692   
    OMIM disorders: 105500  
    UniProtKB/Swiss-Prot: TRPM7_HUMAN, Q96QT4
  • Amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (ALS-PDC1) [MIM:105500]: A
    neurodegenerative disorder characterized by chronic, progressive and uniformly fatal amyotrophic lateral
    sclerosis and parkinsonism-dementia. Both diseases are known to occur in the same kindred, the same sibship and
    even the same individual. Note=Disease susceptibility is associated with variations affecting the gene
    represented in this entry

  • 5 diseases for TRPM7:    
    About MalaCards
    amyotrophic lateral sclerosis-parkinsonism/dementia complex    hypomagnesemia with secondary hypocalcemia    dementia    lateral sclerosis
    amyotrophic lateral sclerosis


    Find genes that share disorders with TRPM7           About GenesLikeMe

    Genetic Association Database (GAD): TRPM7
    Human Genome Epidemiology (HuGE) Navigator: TRPM7 (5 documents)

    Export disorders for TRPM7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TRPM7 gene, integrated from 10 sources (see all 105):
    (articles sorted by number of sources associating them with TRPM7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability. (PubMed id 11385574)1, 2, 3, 9 Nadler M.J.S....Fleig A. (Nature 2001)
    2. TRPM7 is not associated with amyotrophic lateral sclerosis-parkinsonism dementia complex in the Kii peninsula of Japan. (PubMed id 19405049)1, 4, 9 Hara K....Tsuji S. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    3. Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7. (PubMed id 12887921)1, 2, 9 Schmitz C.... Scharenberg A.M. (Cell 2003)
    4. A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian neurodegenerative disorders. (PubMed id 16051700)1, 2, 9 Hermosura M.C.... Garruto R.M. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    5. Gene variation of the transient receptor potential cation channel, subfamily M, members 6 (TRPM6) and 7A (TRPM7), and type 2 diabetes mellitus: a case-control study. (PubMed id 20875900)1, 4 Romero J.R....Zee R.Y. (Transl Res 2010)
    6. Common genetic variants of the ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7), magnesium intake, and risk of type 2 diabetes in women. (PubMed id 19149903)1, 4 Song Y....Liu S. (BMC Med. Genet. 2009)
    7. Gene variation of the transient receptor potential cation channel, subfamily M, member 7 (TRPM7), and risk of incident ischemic stroke: prospective, nested, case-control study. (PubMed id 19644062)1, 4 Romero J.R....Zee R.Y. ( a journal of cerebral circulation 2009)
    8. The relation of magnesium and calcium intakes and a genetic polymorphism in the magnesium transporter to colorectal neoplasia risk. (PubMed id 17823441)1, 4 Dai Q....Zheng W. (Am. J. Clin. Nutr. 2007)
    9. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. (PubMed id 16382100)1, 3 Clapham D.E....Schultz G. (Pharmacol. Rev. 2005)
    10. Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia. (PubMed id 14976260)1, 2 Chubanov V.... Gudermann T. (Proc. Natl. Acad. Sci. U.S.A. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 54822 HGNC: 17994 AceView: TRPM7 Ensembl:ENSG00000092439 euGenes: HUgn54822
    ECgene: TRPM7 Kegg: 54822 H-InvDB: TRPM7

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TRPM7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TRPM7 gene:
    Search GeneIP for patents involving TRPM7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of TRPM7
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TRPM7   OriGene RNAi products in human, mouse, rat for TRPM7  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TRPM7  
     OriGene qSTAR qPCR primer pairs in human, mouse for TRPM7   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TRPM7   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TRPM7   OriGene Custom Protein Services for TRPM7  

     
     
     Block miRNA regulation of human, mouse, rat TRPM7 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TRPM7
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRPM7 Predesigned siRNA for gene silencing in human, mouse, rat TRPM7
     QuantiFast Probe-based Assays in human, mouse, rat TRPM7 QuantiTect SYBR Green Assays in human, mouse, rat TRPM7
     Custom PCR Arrays for TRPM7 Search Chromatin IP Primers for TRPM7
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRPM7  GeneGlobe Interaction Network for TRPM7
     Regulatory tfbs in TRPM7 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TRPM7 GenScript cDNA clones with any tag delivered in your preferred vector for TRPM7
     GenScript Custom Assay Services for TRPM7 GenScript Custom overexpressing Cell Line Services for TRPM7
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TRPM7
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TRPM7 antibodies
     TRPM7 proteins
     Antibodies for TRPM7
     See all of Abcam's Antibodies, Kits and Proteins for TRPM7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TRPM7
     Antibodies for TRPM7
     ELISAs for TRPM7
     CLIAs for TRPM7



     Browse ESI BIO Cell Lines and PureStem Progenitors for TRPM7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPM7
     SwitchGear 3'UTR luciferase reporter plasmids for TRPM7
     SwitchGear Promoter luciferase reporter plasmids for TRPM7
     ThermoFisher Antibodies for TRPM7
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRPM7
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRPM7
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRPM7
     LSBio Antibodies in human, mouse, rat for TRPM7
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for TRPM7
      Search eBioscience for proteins for TRPM7
      Search eBioscience for elisas for TRPM7
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TRPM7 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4