Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRPM7 Gene

protein-coding   GIFtS: 65
GCID: GC15M050852

Transient Receptor Potential Cation Channel, Subfamily M,...

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transient Receptor Potential Cation Channel, Subfamily M, Member 71 2     CHAK2 5
LTRPC72 3 5     ALSPDC2
Channel-Kinase 12 3     TRP-PLIK2
Long Transient Receptor Potential Channel 72 3     LTRPC Ion Channel Family Member 72
CHAK12 3     Transient Receptor Potential Cation Channel Subfamily M Member 72
LTrpC-72 3     Transient Receptor Potential-Phospholipase C-Interacting Kinase2
EC 2.7.11.13 8     LTrpC73

External Ids:    HGNC: 179941   Entrez Gene: 548222   Ensembl: ENSG000000924397   OMIM: 6056925   UniProtKB: Q96QT43   

Export aliases for TRPM7 gene to outside databases

Previous GC identifers: GC15M046409 GC15M043898 GC15M048431 GC15M048568 GC15M048639 GC15M027680


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRPM7 Gene:
The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity
is essential for the ion channel function, which serves to increase intracellular calcium levels and to help
regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral
sclerosis-parkinsonism/dementia complex of Guam.(provided by RefSeq, May 2010)

GeneCards Summary for TRPM7 Gene: 
TRPM7 (transient receptor potential cation channel, subfamily M, member 7) is a protein-coding gene. Diseases associated with TRPM7 include hypomagnesemia with secondary hypocalcemia, and amyotrophic lateral sclerosis-parkinsonism/dementia complex 1, and among its related super-pathways are CREB Pathway. GO annotations related to this gene include protein serine/threonine kinase activity and calcium channel activity. An important paralog of this gene is TRPM2.

UniProtKB/Swiss-Prot: TRPM7_HUMAN, Q96QT4
Function: Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium
and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell
death. The kinase activity is essential for the channel function. May be involved in a fundamental process that
adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates
annexin A1 (ANXA1)

Gene Wiki entry for TRPM7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRPM7 gene promoter:
         Sox5   HNF-3beta   AP-2gamma   Evi-1   FOXL1   IRF-7A   AP-2beta   AP-2alpha   ATF6   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRPM7 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRPM7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRPM7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21   Ensembl cytogenetic band:  15q21.2   HGNC cytogenetic band: 15q21

TRPM7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRPM7 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M050852:  view genomic region     (about GC identifiers)

Start:
50,844,670 bp from pter      End:
50,979,012 bp from pter
Size:
134,343 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRPM7_HUMAN, Q96QT4 (See protein sequence)
Recommended Name: Transient receptor potential cation channel subfamily M member 7  
Size: 1865 amino acids; 212697 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Homodimer. Interacts with PLCB1 (By similarity). Forms heterodimers with TRPM6
Subcellular location: Membrane; Multi-pass membrane protein (Probable)
Sequence caution: Sequence=BAC11462.1; Type=Erroneous initiation; Sequence=BAD18773.1; Type=Erroneous initiation;
Secondary accessions: Q6ZMF5 Q86VJ4 Q8NBW2 Q9BXB2 Q9NXQ2

Explore the universe of human proteins at neXtProt for TRPM7: NX_Q96QT4

Explore proteomics data for TRPM7 at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96QT4

  • 4/25 DME Specific Peptides for TRPM7 (Q96QT4) (see all 25)
     WSVEKHT  PWGVIEN  AGRLIYC  SMSSWSQ 

    TRPM7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRPM7 Protein Expression
    REFSEQ proteins: NP_060142.3  
    ENSEMBL proteins: 
     ENSP00000454066   ENSP00000453277   ENSP00000320239   ENSP00000452873  

    Human Recombinant Protein Products for TRPM7: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TRPM7
    GenScript Custom Purified and Recombinant Proteins Services for TRPM7
    Novus Biologicals TRPM7 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRPM7 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IEA--
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    TRPM7 for ontologies           About GeneDecksing



    TRPM7 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TRPM7
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TRPM7
    OriGene Custom Antibody Services for TRPM7
    GenScript Custom Superior Antibodies Services for TRPM7
    Novus Biologicals TRPM7 Antibodies
    Abcam antibodies for TRPM7
    Cloud-Clone Corp. Antibodies for TRPM7 
    ThermoFisher Antibodies for TRPM7
    LSBio Antibodies in human, mouse, rat for TRPM7 

    Assay Products for TRPM7: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TRPM7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRPM7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TRPM7 
    Cloud-Clone Corp. CLIAs for TRPM7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TRP: Voltage-gated ion channels / Transient receptor potential cation channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: TRPM7 
    ChaK subfamily
    Transient Receptor Potential channels

    3 InterPro protein domains:
     IPR011009 Kinase-like_dom
     IPR005821 Ion_trans_dom
     IPR004166 MHCK_EF2_kinase

    Graphical View of Domain Structure for InterPro Entry Q96QT4

    ProtoNet protein and cluster: Q96QT4

    UniProtKB/Swiss-Prot: TRPM7_HUMAN, Q96QT4
    Similarity: In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase
    family. ALPK subfamily
    Similarity: In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM7
    sub-subfamily
    Similarity: Contains 1 alpha-type protein kinase domain


    TRPM7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRPM7_HUMAN, Q96QT4
    Function: Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium
    and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell
    death. The kinase activity is essential for the channel function. May be involved in a fundamental process that
    adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates
    annexin A1 (ANXA1)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Number (IUBMB): EC 2.7.11.11 2

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0005216ion channel activity ----
    GO:0005262calcium channel activity IEA--
    GO:0005524ATP binding IEA--
         
    TRPM7 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for TRPM7:
     Decreased substrate adherent c  Decreased viability of wild-ty  Increased cell death in HCT116 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Trpm7):
     cellular  hematopoietic system  immune system  mortality/aging 

    TRPM7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Trpm7tm1.1Clph for TRPM7

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRPM7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRPM7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRPM7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRPM7 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRPM7
    8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate TRPM7 (see all 88):
    hsa-miR-579 hsa-miR-3607-3p hsa-miR-300 hsa-miR-4272 hsa-miR-30d hsa-miR-632 hsa-miR-578 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidTRPM7 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TRPM7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRPM7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRPM7
    Sirion Biotech Customized adenovirus for overexpression of TRPM7

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TRPM7 (see all 7)
    OriGene ORF clones in mouse, rat for TRPM7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRPM7 (NM_017672)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRPM7
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRPM7

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TRPM7
    Search LifeMap BioReagents cell lines for TRPM7
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPM7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TRPM7 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1CREB Pathway
    Intracellular Calcium Signaling0.50
    2Mineral absorption
    Mineral absorption
    3Calcium channels
    Calcium channels

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TRPM7
        Calcium channels

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TRPM7
        Intracellular Calcium Signaling


    1         Kegg Pathway  (Kegg details for TRPM7):
        Mineral absorption


    TRPM7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRPM7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/16 Interacting proteins for TRPM7 (Q96QT42, 3 ENSP000003202394) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYH10P355802, 3, ENSP000002692434MINT-6699391 I2D: score=1 STRING: ENSP00000269243
    MYH9P355792, 3, ENSP000002161814MINT-6699369 I2D: score=3 STRING: ENSP00000216181
    MYH14Q7Z4062, 3, ENSP000004078794MINT-6699418 I2D: score=1 STRING: ENSP00000407879
    MBPP026863, ENSP000003482734I2D: score=2 STRING: ENSP00000348273
    PLCB1Q9NQ663, ENSP000003381854I2D: score=2 STRING: ENSP00000338185
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0006811ion transport ----
    GO:0006816calcium ion transport ----
    GO:0008219cell death IEA--
    GO:0016340calcium-dependent cell-matrix adhesion IEA--

    TRPM7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRPM7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRPM7

    4 HMDB Compounds for TRPM7    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--

    3 DrugBank Compounds for TRPM7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1,4-Dithiothreitol-- --target--10592235
    Adenosine-5'-Diphosphate-- 20398-34-9target--10592235
    Phosphoaminophosphonic Acid-Adenylate Ester-- --target--10592235

    8 IUPHAR Ligands for TRPM7 (TRPM7)    About this table 
    LigandTypeActionAffinityPubmed IDs
    cAMP
    ActivatorNone--
    carvacrol
    Channel blockerNone--
    ATP
    ActivatorPotentiation--
    spermine
    Channel blockerNone--
    La3+
    Channel blockerNone--
    2-APB
    Channel blockerNone--
    H+ (extracellular)
    ActivatorPotentiation--
    Mg2+
    Channel blockerNone--

    3 Novoseek inferred chemical compound relationships for TRPM7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    magnesium 57.8 21 17599911 (5), 16051700 (4), 18192217 (3), 16258415 (3) (see all 7)
    threonine 20.2 5 17217065 (1), 11941371 (1)
    serine 4.6 5 17217065 (1), 11941371 (1)

    Search CenterWatch for drugs/clinical trials and news about TRPM7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRPM7 gene: 
    NM_017672.4  

    Unigene Cluster for TRPM7:

    Transient receptor potential cation channel, subfamily M, member 7
    Hs.512894  [show with all ESTs]
    Unigene Representative Sequence: NM_017672
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000561267 ENST00000560955(uc001zyr.3) ENST00000313478(uc001zyt.4 uc010bew.2)
    ENST00000561443 ENST00000560516 ENST00000558444 ENST00000560849 ENST00000560284
    ENST00000560638(uc001zyu.3)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRPM7
    8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate TRPM7 (see all 88):
    hsa-miR-579 hsa-miR-3607-3p hsa-miR-300 hsa-miR-4272 hsa-miR-30d hsa-miR-632 hsa-miR-578 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidTRPM7 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TRPM7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRPM7
    Clone
    Products:
         
    OriGene clones in human, mouse for TRPM7 (see all 7)
    OriGene ORF clones in mouse, rat for TRPM7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRPM7 (NM_017672)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRPM7
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRPM7
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TRPM7
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRPM7
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRPM7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRPM7

    Additional mRNA sequence: 

    AF346629.2 AK000124.1 AK075193.1 AK098584.1 AK172800.1 BC028843.1 BC051024.1 BC128987.1 
    BC128988.1 

    12 DOTS entries:

    DT.112493  DT.91748369  DT.40111505  DT.95200599  DT.70104997  DT.100021316  DT.112492  DT.75173963 
    DT.75131160  DT.95096970  DT.95358754  DT.104153 

    24/175 AceView cDNA sequences (see all 175):

    BX952858 CK724921 AJ289816 AA642331 CB162659 BQ002389 BQ010890 BQ432223 
    AA261876 AF346629 W04694 BU153353 CA430562 AK000124 AK098584 AA261842 
    AI160721 BC051024 BE857499 BQ428396 AA262742 AI610861 NM_017672 BX495468 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TRPM7 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                    -                                       
    SP5:                                                                                                                                                            

    ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b ^ 32 ^ 33 ^ 34 ^ 35 ^ 36a · 36b
    SP1:                                                                                    
    SP2:                                                                                    
    SP3:                                                                                    
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for TRPM7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRPM7 expression in normal human tissues (normalized intensities)      TRPM7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGCTGTTT
    TRPM7 Expression
    About this image


    TRPM7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             oocyte   
     
     Kidney (Urinary System)
             Loop of Henle Cells Loop of Henle

    See TRPM7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRPM7

    SOURCE GeneReport for Unigene cluster: Hs.512894
        SABiosciences Custom PCR Arrays for TRPM7
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TRPM7
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRPM7
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRPM7
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRPM7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPM7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TRPM7 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trpm71 , 5 transient receptor potential cation channel, subfamily more1, 5 90.83(n)1
    94.36(a)1
      2 (61.76 cM)5
    588001  NM_001164325.11  NP_001157797.11 
     1267915655 
    chicken
    (Gallus gallus)
    Aves TRPM71 transient receptor potential cation channel, subfamily more 82.3(n)
    87.9(a)
      427502  NM_001177555.1  NP_001171026.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRPM76
    transient receptor potential cation channel, subfa...
    84(a)
    1 ↔ 1
    GL343747.1(104352-154466)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480127392   -- 78.97(n)    48012739 
    zebrafish
    (Danio rerio)
    Actinopterygii 570532592   -- 75.28(n)   322919  57053259 


    ENSEMBL Gene Tree for TRPM7 (if available)
    TreeFam Gene Tree for TRPM7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRPM7 gene
    TRPM22  TRPM52  TRPM82  TRPM62  TRPM12  TRPM32  TRPM42  
    4 SIMAP similar genes for TRPM7 using alignment to 3 protein entries:     TRPM7_HUMAN (see all proteins):
    MLSN2    TRPM3    TRPM6    TRPM1

    TRPM7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3196 SNPs in TRPM7 are shown (see all 3196)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0424004
    A gastric adenocarcinoma sample4--see VAR_0424002 M V mis40--------
    VAR_0423964
    An ovarian serous carcinoma sample4--see VAR_0423962 S C mis40--------
    VAR_0423994
    A breast infiltrating ductal carcinoma sample4--see VAR_0423992 T S mis40--------
    rs80429191,2,4
    C,F,A,Hother130945207(+) AGTCAG/ATAAAT 2 /T /I mis1 ese327Minor allele frequency- A:0.09PA EA NA NS EU 3657
    rs743349681,2
    C--27681811(+) ACACT-/CCAGCC 1 -- ut310--------
    rs344616331,2
    C--27682963(+) GTCTC-/AAAAAA 1 -- ut310--------
    rs2007245881,2
    --27695013(+) TTCTT-/TATATAT 1 -- int10--------
    rs593233351,2
    C--27695033(+) GTTTA-/ATCT  
      TTAT
    /T
    ACTTG
    1 -- int10--------
    rs30778721,2
    C--27706872(-) GTCTC-/A/AAA 
            
    AAAAA
    2 -- int1 cds1 trp32NA CSA 4
    rs1461803711,2
    C--27711691(+) TTAAA-/TTAAG 
            
    TTAAT
    1 -- int10--------

    HapMap Linkage Disequilibrium report for TRPM7 (50844670 - 50979012 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for TRPM7 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2749686CNV Deletion23290073
    esv2664477CNV Deletion23128226
    esv2674857CNV Deletion23128226
    esv2749687CNV Deletion23290073
    esv1392000CNV Insertion17803354
    nsv1532CNV Insertion18451855
    nsv524596CNV Loss19592680
    nsv904211CNV Loss21882294
    nsv524613CNV Loss19592680
    dgv317n27CNV Gain19166990


    Human Gene Mutation Database (HGMD): TRPM7
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TRPM7
    DNA2.0 Custom Variant and Variant Library Synthesis for TRPM7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605692   
    OMIM disorders: 105500  
    UniProtKB/Swiss-Prot: TRPM7_HUMAN, Q96QT4
  • Amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (ALS-PDC1) [MIM:105500]: A
    neurodegenerative disorder characterized by chronic, progressive and uniformly fatal amyotrophic lateral
    sclerosis and parkinsonism-dementia. Both diseases are known to occur in the same kindred, the same sibship and
    even the same individual. Note=Disease susceptibility is associated with variations affecting the gene
    represented in this entry

  • 14 diseases for TRPM7:    About MalaCards
    hypomagnesemia with secondary hypocalcemia    amyotrophic lateral sclerosis-parkinsonism/dementia complex 1    dementia    lateral sclerosis
    amyotrophic lateral sclerosis    brain ischemia    ischemia    diabetes mellitus
    hypertension    gastric cancer    endotheliitis    pancreatitis
    breast cancer    neuronitis


    TRPM7 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): TRPM7
    Human Genome Epidemiology (HuGE) Navigator: TRPM7 (5 documents)

    Export disorders for TRPM7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRPM7 gene, integrated from 9 sources (see all 101):
    (articles sorted by number of sources associating them with TRPM7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability. (PubMed id 11385574)1, 2, 3, 9 Nadler M.J.S....Fleig A. (2001)
    2. TRPM7 is not associated with amyotrophic lateral sclerosis-parkinsonism dementia complex in the Kii peninsula of Japan. (PubMed id 19405049)1, 4, 9 Hara K....Tsuji S. (2009)
    3. Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7. (PubMed id 12887921)1, 2, 9 Schmitz C.... Scharenberg A.M. (2003)
    4. A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian neurodegenerative disorders. (PubMed id 16051700)1, 2, 9 Hermosura M.C.... Garruto R.M. (2005)
    5. Gene variation of the transient receptor potential ca tion channel, subfamily M, members 6 (TRPM6) and 7 (TRPM7), and type 2 diabetes mellitus: a case-control study. (PubMed id 20875900)1, 4 Romero J.R....Zee R.Y. (2010)
    6. Common genetic variants of the ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7), magnesium intake, and risk of type 2 diabetes in women. (PubMed id 19149903)1, 4 Song Y....Liu S. (2009)
    7. Gene variation of the transient receptor potential ca tion channel, subfamily M, member 7 (TRPM7), and risk of incident ischemic stro ke: prospective, nested, case-control study. (PubMed id 19644062)1, 4 Romero J.R....Zee R.Y. (2009)
    8. The relation of magnesium and calcium intakes and a genetic polymorphism in the magnesium transporter to colorectal neoplasia risk. (PubMed id 17823441)1, 4 Dai Q....Zheng W. (2007)
    9. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. (PubMed id 16382100)1, 3 Clapham D.E....Schultz G. (2005)
    10. Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia. (PubMed id 14976260)1, 2 Chubanov V.... Gudermann T. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54822 HGNC: 17994 AceView: TRPM7 Ensembl:ENSG00000092439 euGenes: HUgn54822
    ECgene: TRPM7 Kegg: 54822 H-InvDB: TRPM7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRPM7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRPM7 gene:
    Search GeneIP for patents involving TRPM7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of TRPM7
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TRPM7   OriGene RNAi products in human, mouse, rat for TRPM7  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TRPM7  
     OriGene qSTAR qPCR primer pairs in human, mouse for TRPM7   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TRPM7   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TRPM7   OriGene Custom Protein Services for TRPM7  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRPM7
     QIAGEN SeqTarget long-range PCR primers for resequencing TRPM7
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRPM7
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRPM7
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRPM7
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRPM7
     GenScript Custom Purified and Recombinant Proteins Services for TRPM7 GenScript cDNA clones with any tag delivered in your preferred vector for TRPM7
     GenScript Custom Assay Services for TRPM7 GenScript Custom Superior Antibodies Services for TRPM7
     GenScript Custom overexpressing Cell Line Services for TRPM7 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TRPM7 promoter
     Search Chromatin IP Primers for TRPM7
     RT2 qPCR Primer Assay in human, mouse, rat TRPM7
     GNC Network for TRPM7
     SABiosciences PCR Arrays including human, mouse, rat TRPM7
     Search Tocris compounds for TRPM7
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TRPM7 antibodies
     TRPM7 proteins
     Antibodies for TRPM7
     See all of Abcam's Antibodies, Kits and Proteins for TRPM7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for TRPM7
     Antibodies for TRPM7
     ELISAs for TRPM7
     CLIAs for TRPM7
     Search LifeMap BioReagents cell lines for TRPM7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPM7
     SwitchGear 3'UTR luciferase reporter plasmids for TRPM7
     SwitchGear Promoter luciferase reporter plasmids for TRPM7
     ThermoFisher Antibodies for TRPM7
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRPM7
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TRPM7
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRPM7
    Customized:
     lentivirus for stable overexpression
     lentivirus expression plasmids for stable overexpression
     adenovirus for overexpression of TRPM7
     LSBio Antibodies in human, mouse, rat for TRPM7
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TRPM7 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4