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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRPM5 Gene

protein-coding   GIFtS: 54
GCID: GC11M002425

Transient Receptor Potential Cation Channel, Subfamily M,...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transient Receptor Potential Cation Channel, Subfamily M, Member 51 2     MLSN1- And TRP-Related Gene 1 Protein2 3
MTR12 3 5     MLSN1 And TRP-Related2
Long Transient Receptor Potential Channel 52 3     Transient Receptor Potential Cation Channel Subfamily M Member 52
LTRPC52 3     LTrpC53
LTrpC-52 3     

External Ids:    HGNC: 143231   Entrez Gene: 298502   Ensembl: ENSG000000709857   OMIM: 6046005   UniProtKB: Q9NZQ83   

Export aliases for TRPM5 gene to outside databases

Previous GC identifers: GC11M002487 GC11M002626 GC11M002385 GC11M002390 GC11M002382 GC11M002216


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRPM5 Gene:
This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of
proteins with structural features typical of ion channels. This protein plays an important role in taste
transduction, and has characteristics of a calcium-activated, non-selective cation channel that carries Na+, K+,
and Cs+ ions equally well, but not Ca(2+) ions. It is activated by lower concentrations of intracellular Ca(2+),
and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat activated channel showing
a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located
within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5, and has been shown to be
imprinted, with exclusive expression from the paternal allele. (provided by RefSeq, Oct 2010)

GeneCards Summary for TRPM5 Gene: 
TRPM5 (transient receptor potential cation channel, subfamily M, member 5) is a protein-coding gene. Diseases associated with TRPM5 include beckwith-wiedemann syndrome, and wilms tumor, and among its related super-pathways are CREB Pathway and Class C/3 (Metabotropic glutamate/pheromone receptors). GO annotations related to this gene include ion channel activity and potassium channel activity. An important paralog of this gene is TRPM2.

UniProtKB/Swiss-Prot: TRPM5_HUMAN, Q9NZQ8
Function: Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane
depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel
that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in
intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and
deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a
fast intracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The
channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block
of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive,
heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees
Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials.
Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also
be involved in sensing semiochemicals

Gene Wiki entry for TRPM5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRPM5 gene promoter:
         Max   Pbx1a   Sp1   MyoD   Pax-4a   c-Myc   Arnt   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRPM5 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRPM5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRPM5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

TRPM5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRPM5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M002425:  view genomic region     (about GC identifiers)

Start:
2,425,745 bp from pter      End:
2,444,275 bp from pter
Size:
18,531 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRPM5_HUMAN, Q9NZQ8 (See protein sequence)
Recommended Name: Transient receptor potential cation channel subfamily M member 5  
Size: 1165 amino acids; 131451 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (Potential)
Secondary accessions: A6NHS0 Q52LU2 Q9NY34
Alternative splicing: 3 isoforms:  Q9NZQ8-1   Q9NZQ8-2   Q9NZQ8-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRPM5: NX_Q9NZQ8

Explore proteomics data for TRPM5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NZQ8

  • TRPM5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRPM5 Protein Expression
    REFSEQ proteins: NP_055370.1  
    ENSEMBL proteins: 
     ENSP00000434383   ENSP00000155858   ENSP00000434121   ENSP00000436809   ENSP00000387965  

    Human Recombinant Protein Products for TRPM5: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRPM5 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    TRPM5 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for TRPM5 
    Cloud-Clone Corp. CLIAs for TRPM5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TRP: Voltage-gated ion channels / Transient receptor potential cation channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: TRPM5 
    Transient Receptor Potential channels

    ProtoNet protein and cluster: Q9NZQ8

    UniProtKB/Swiss-Prot: TRPM5_HUMAN, Q9NZQ8
    Similarity: Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM5 sub-subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRPM5_HUMAN, Q9NZQ8
    Function: Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane
    depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel
    that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in
    intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and
    deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a
    fast intracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The
    channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block
    of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive,
    heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees
    Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials.
    Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also
    be involved in sensing semiochemicals

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity TAS10607831
    GO:0005227calcium activated cation channel activity IEA--
    GO:0005244voltage-gated ion channel activity IEA--
    GO:0005267potassium channel activity IEA--
    GO:0005272sodium channel activity IEA--
         
    TRPM5 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Trpm5):
     hematopoietic system  immune system  normal  taste/olfaction 

    TRPM5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TRPM5: Trpm5tm1Csz Trpm5tm1Sdmk

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRPM5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRPM5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRPM5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRPM5 

    miRNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPM5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TRPM5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1CREB Pathway
    Intracellular Calcium Signaling0.50
    2Class C/3 (Metabotropic glutamate/pheromone receptors)
    Taste transduction0.45
    3Sodium channels and transporters: inward current
    Sodium channels and transporters: inward current

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TRPM5
        Sodium channels and transporters- inward current

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TRPM5
        Intracellular Calcium Signaling


    1         Kegg Pathway  (Kegg details for TRPM5):
        Taste transduction


    TRPM5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRPM5

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TRPM5 (ENSP000001558584) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITPR3ENSP000003634354STRING: ENSP00000363435
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0034220ion transmembrane transport ----
    GO:0035725sodium ion transmembrane transport ----
    GO:0071805potassium ion transmembrane transport ----

    TRPM5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRPM5

    4 IUPHAR Ligands for TRPM5 (TRPM5)    About this table 
    LigandTypeActionAffinityPubmed IDs
    Ca2+
    ActivatorNone6.1 - 6.2--
    spermine
    Channel blockerNone4.43--
    H+ (extracellular)
    Channel blockerNone3.2--
    rosiglitazone
    ActivatorNone3.221406603

    Search CenterWatch for drugs/clinical trials and news about TRPM5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRPM5 gene: 
    NM_014555.3  

    Unigene Cluster for TRPM5:

    Transient receptor potential cation channel, subfamily M, member 5
    Hs.272287  [show with all ESTs]
    Unigene Representative Sequence: NM_014555
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533881 ENST00000155858(uc001lwm.4 uc010qxl.2) ENST00000533060
    ENST00000528453 ENST00000452833(uc009ydn.3)
    miRNA
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    GenScript: all cDNA clones in your preferred vector: TRPM5 (NM_014555)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRPM5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPM5
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRPM5

    Additional mRNA sequence: 

    AF177473.1 AJ270996.1 BC093787.1 BC093789.1 BC143351.1 BC143353.1 

    1 DOTS entry:

    DT.40287186 

    11 AceView cDNA sequences:

    AJ270996 AA577486 NM_014555 AF177473 BE969893 BF814862 BF899960 BF815505 
    BF816249 BF814864 BF814861 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for TRPM5    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24
    SP1:                                                                                                                                                      
    SP2:                                                                                                                                                      


    ECgene alternative splicing isoforms for TRPM5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRPM5 expression in normal human tissues (normalized intensities)      TRPM5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TRPM5 Expression
    About this image


    TRPM5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Zeugopod Growth Plate
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Heart (Cardiovascular System)
             Atrioventricular Node Cells Atrioventricular Node
     
     Colon (Gastrointestinal Tract)

    See TRPM5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRPM5

    SOURCE GeneReport for Unigene cluster: Hs.272287

    UniProtKB/Swiss-Prot: TRPM5_HUMAN, Q9NZQ8
    Tissue specificity: Strongly expressed in fetal brain, liver and kidney, and in adult prostate, testis, ovary,
    colon and peripheral blood leukocytes. Also expressed in a large proportion of Wilms' tumors and
    rhabdomyosarcomas. In monochromosomal cell lines shows exclusive paternal expression

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPM5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TRPM5 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trpm51 , 5 transient receptor potential cation channel, subfamily more1, 5 82.54(n)1
    85.02(a)1
      7 (88.11 cM)5
    568431  NM_020277.21  NP_064673.21 
     1430691535 
    chicken
    (Gallus gallus)
    Aves TRPM51 transient receptor potential cation channel, subfamily more 65.97(n)
    68.94(a)
      423091  XM_003641321.1  XP_003641369.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    65(a)
    65(a)
    1 ↔ many
    1 ↔ many
    1(69480371-69509444)
    1(69462370-69478841)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.133792 Xenopus laevis transcribed sequence with weak similarity more 75.41(n)    BJ036400.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5577221 similar to transient receptor potential cation channel, more 64.48(n)
    61.83(a)
      557722  NM_001128239.1  NP_001121711.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta trpm6
    --
    14(a)
    possible ortholog
    2R(11150309-11180386)
    worm
    (Caenorhabditis elegans)
    Secernentea gtl-26
    gtl-16
    (see all 4)
    Protein GTL-1
    (see all 4)
    18(a)
    15(a)
    (see all 4)
    possible ortholog
    possible ortholog
    (see all 4)
    IV(11273483-11281924)
    IV(11248902-11259465)


    ENSEMBL Gene Tree for TRPM5 (if available)
    TreeFam Gene Tree for TRPM5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRPM5 gene
    TRPM22  TRPM82  TRPM72  TRPM62  TRPM12  TRPM32  TRPM42  
    5 SIMAP similar genes for TRPM5 using alignment to 5 protein entries:     TRPM5_HUMAN (see all proteins):
    TRPM4    TRPM2    MLSN2    TRPM8    TRPM3

    TRPM5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/871 SNPs in TRPM5 are shown (see all 871)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1422626001,2
    --2425904(+) GGATGC/GGGTGG 1 -- ut310--------
    rs1896750101,2
    --2425961(+) CCATGA/GCACTG 1 -- ut310--------
    rs1478862621,2
    C--2426002(+) GGAGCA/GGTTCC 1 -- ut310--------
    rs1176965431,2
    F--2426056(+) TGCTGG/TGGGGC 1 -- ut311Minor allele frequency- T:0.01EA 120
    rs79347291,2
    C,F,H--2426100(+) CAAAGG/ATCAGT 1 -- ut31 ese321Minor allele frequency- A:0.08MN NS EA WA NA CSA 2529
    rs1170791011,2
    C--2426173(+) CAGGTA/C/G/
            
    TCCGA
    4 E D mis1 syn12EA EU 1077
    rs1454205931,2
    C--2426176(+) GTGTCC/TGAGGG 2 S syn10--------
    rs1499308241,2
    C,F--2426208(+) TTCCCA/GGCCAT 2 R W mis11Minor allele frequency- G:0.00NA 4536
    rs1464991891,2
    C,F--2426215(+) CCATCT/GAAACC 2 /L /F mis11Minor allele frequency- G:0.00NA 4534
    rs2018002981,2
    C--2426219(+) CTAAAC/G/TCACCT 3 D A G mis10--------

    HapMap Linkage Disequilibrium report for TRPM5 (2425745 - 2444275 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for TRPM5 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2744007CNV Deletion23290073
    nsv509382CNV Insertion20534489
    nsv896812CNV Loss21882294
    nsv469928CNV Loss18288195
    nsv896806CNV Loss21882294
    dgv1000n71CNV Loss21882294
    nsv896811CNV Loss21882294
    nsv896821CNV Loss21882294
    nsv896820CNV Loss21882294
    nsv825714CNV Gain20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604600    OMIM disorders: --

    4 diseases for TRPM5:    About MalaCards
    beckwith-wiedemann syndrome    wilms tumor    rhabdomyosarcoma    prostatitis


    TRPM5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TRPM5
    Human Genome Epidemiology (HuGE) Navigator: TRPM5 (4 documents)

    Export disorders for TRPM5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRPM5 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with TRPM5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele- specific expression. (PubMed id 10607831)1, 2, 3 Prawitt D.... Zabel B. (2000)
    2. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)
    3. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. (PubMed id 16382100)1, 3 Clapham D.E....Schultz G. (2005)
    4. TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i. (PubMed id 14634208)1, 2 Prawitt D....Penner R. (2003)
    5. Genetic variation within the TRPM5 locus associates w ith prediabetic phenotypes in subjects at increased risk for type 2 diabetes. (PubMed id 21489577)1 Ketterer C....Staiger H. (2011)
    6. Overexpression of human transient receptor potential M5 upregulates endogenous human transient receptor potential A1 in a stable HEK cell line. (PubMed id 21133676)1 Buber M.T....Lee S.P. (2010)
    7. Association between common variation in genes encodin g sweet taste signaling components and human sucrose perception. (PubMed id 20660057)1 Fushan A.A....Drayna D. (2010)
    8. TRPM5 and taste transduction. (PubMed id 17217064)1 Liman E.R. (2007)
    9. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
    10. Extracellular acid block and acid-enhanced inactivation of the Ca2+-activated cation channel TRPM5 involve residues in the S3-S4 and S5-S6 extracellular domains. (PubMed id 15731110)1 Liu D....Liman E.R. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29850 HGNC: 14323 AceView: TRPM5 Ensembl:ENSG00000070985 euGenes: HUgn29850
    ECgene: TRPM5 Kegg: 29850 H-InvDB: TRPM5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRPM5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRPM5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRPM5 gene:
    Search GeneIP for patents involving TRPM5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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