TRPM5 Gene
protein-coding GIFtS : 53
GCID: GC11 M002425
transient receptor potential cation channel, subfamily M,...
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Aliasesfor TRPM5 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Transient Receptor Potential Cation Channel, Subfamily M, Member 5 1 2 MLSN1- And TRP-Related Gene 1 Protein2 3 MTR11 2 3 5 MLSN1 And TRP-Related2 LTRPC51 2 3 Transient Receptor Potential Cation Channel Subfamily M Member 52 Long Transient Receptor Potential Channel 52 3 LTrpC53 LTrpC-52 3
Export aliases for TRPM5 gene to outside databases Previous GC identifers: GC11M002487 GC11M002626 GC11M002385 GC11M002390 GC11M002382 GC11M002216
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Summariesfor TRPM5 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for TRPM5 : This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction, and has characteristics of a calcium-activated, non-selective cation channel that carries Na+, K+, and Cs+ ions equally well, but not Ca(2+) ions. It is activated by lower concentrations of intracellular Ca(2+), and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5, and has been shown to be imprinted, with exclusive expression from the paternal allele. (provided by RefSeq, Oct 2010) UniProtKB/Swiss-Prot: TRPM5_HUMAN, Q9NZQ8 Function : Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membranedepolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals Gene Wiki entry for TRPM5
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Genomic Viewsfor TRPM5 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000011.9 NC_018922.1 NT_009237.18 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TRPM5 gene promoter: Max Pbx1a Sp1 MyoD Pax-4a c-Myc Arnt E47 Other transcription factors Search SABiosciences Chromatin IP Primers for TRPM5 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRPM5
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15.5 TRPM5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11M002425: view genomic region
(about GC identifiers )
Start:
2,425,745 bp from pter
End:
2,444,275 bp from pter
Size:
18,531 bases
Orientation:
minus strand
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Proteinsfor TRPM5 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TRPM5_HUMAN, Q9NZQ8 (See
protein sequence )Recommended Name: Transient receptor potential cation channel subfamily M member 5 Size : 1165 amino acids; 131451 Da
Subcellular location : Cell membrane; Multi-pass membrane protein (Potential)
Secondary accessions : A6NHS0 Q52LU2 Q9NY34Alternative splicing : 3 isoforms : Q9NZQ8-1 Q9NZQ8-2 Q9NZQ8-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TRPM5: NX_Q9NZQ8 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9NZQ8 TRPM5 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_055370.1 ENSEMBL proteins: ENSP00000434383 ENSP00000155858 ENSP00000434121 ENSP00000436809 ENSP00000387965 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005886 plasma membrane
IEA -- GO:0016021 integral to membrane
IEA --
TRPM5 for ontologies About GeneDecksing TRPM5 Antibody Products: Assay Products for TRPM5:
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Protein
Domains / Familiesfor TRPM5 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section ProtoNet protein and cluster: Q9NZQ8
UniProtKB/Swiss-Prot: TRPM5_HUMAN, Q9NZQ8 Similarity : Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM5 sub-subfamily
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Functionfor TRPM5 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: TRPM5_HUMAN, Q9NZQ8 Function : Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membranedepolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TRPM5 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TRPM5OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TRPM5 (NM_014555 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRPM5 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TRPM5
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPM5
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6 ): About this table
TRPM5 for ontologies About GeneDecksing Animal Models: Mouse knock-outs for TRPM5: Trpm5 tm1Csz Trpm5 tm1Sdmk 4 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Trpm5) :
TRPM5 for phenotypes About GeneDecksing
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Pathways & Interactionsfor TRPM5 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Taste transduction 2 Sodium channels and transporters: inward current 3 CREB Pathway
Pathway sources See GeneCards unified pathways Show all pathways 1 EMD Millipore Pathway for TRPM5 1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TRPM5 1
Kegg Pathway (Kegg details for TRPM5) :
TRPM5 for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRPM5 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for TRPM5 (ENSP00000155858 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 3 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0034220 ion transmembrane transport
-- -- GO:0035725 sodium ion transmembrane transport
-- -- GO:0071805 potassium ion transmembrane transport
-- --
TRPM5 for ontologies About GeneDecksing
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Drugs & Compoundsfor TRPM5 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TRPM5 Search CenterWatch for drugs/clinical trials and news about TRPM5
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Transcriptsfor TRPM5 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TRPM5 gene: NM_014555.3 Unigene Cluster for TRPM5:
Transient receptor potential cation channel, subfamily M, member 5 Hs.272287 [show with all ESTs ] Unigene Representative Sequence: NM_014555 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000533881 ENST00000155858 (uc001lwm.4 uc010qxl.2 ) ENST00000533060 ENST00000528453 ENST00000452833 (uc009ydn.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TRPM5 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TRPM5OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TRPM5 (NM_014555 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRPM5 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TRPM5
Additional cDNA sequence: AF177473.1 AJ270996.1 BC093787.1 BC093789.1 BC143351.1 BC143353.1
1 DOTS entry : DT.40287186
11 AceView cDNA sequences :
AA577486 AJ270996 NM_014555 AF177473 BE969893 BF814864 BF815505 BF814862 BF899960 BF816249 BF814861 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for TRPM5 About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 SP1 :                                                   SP2 :                                                  
ECgene alternative splicing isoforms for TRPM5
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Expression for TRPM5 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TRPM5 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image TRPM5 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 2 LifeMap In Vivo Development Anatomical Compartments/Cells Tissue Anatomical Compartment
Cell Category (developmental path) Bone Zeugopod Epiphyseal End Bone Bone Zeugopod Growth Plate Bone Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See TRPM5 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TRPM5 SOURCE GeneReport for Unigene cluster: Hs.272287 UniProtKB/Swiss-Prot: TRPM5_HUMAN, Q9NZQ8 Tissue specificity : Strongly expressed in fetal brain, liver and kidney, and in adult prostate, testis, ovary, colonand peripheral blood leukocytes. Also expressed in a large proportion of Wilms' tumors and rhabdomyosarcomas. In monochromosomal cell lines shows exclusive paternal expression SABiosciences Custom PCR Arrays for TRPM5 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TRPM5Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat TRPM5 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TRPM5 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TRPM5 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPM5
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Orthologsfor TRPM5 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for TRPM5 gene from 5/15 species (see all 15 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
TRPM51
transient receptor potential cation channel, subfamily more
65.97(n) 68.94(a)
 
423091 XM_003641321.1 XP_003641369.1
lizard (Anolis carolinensis)
Reptilia
----
--
65(a) 65(a)
1 ↔ many1 ↔ many
1(69462370-69478841) 1(69480371-69509444)
African clawed frog (Xenopus laevis)
Amphibia
Xl.133792
Xenopus laevis transcribed sequence with weak similarity more
75.41(n)
 
BJ036400.1
zebrafish (Danio rerio)
Actinopterygii
LOC5577221
similar to transient receptor potential cation channel, more
64.48(n) 61.83(a)
 
557722 NM_001128239.1 NP_001121711.1
worm (Caenorhabditis elegans)
Secernentea
ced-116
Protein ced-11
11(a)
possible ortholog
III(9119482-9125073)
ENSEMBL Gene Tree for TRPM5 (if available)TreeFam Gene Tree for TRPM5 (if available)
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Paralogsfor TRPM5 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for TRPM5 gene TRPM2 2 TRPM8 2 TRPM7 2 TRPM1 2 TRPM6 2 TRPM4 2 TRPM3 2 5 SIMAP similar genes for TRPM5 using alignment to 5 protein entries: TRPM5_HUMAN (see all proteins ):TRPM4 TRPM2 MLSN2 TRPM8 TRPM3
TRPM5 for paralogs About GeneDecksing
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Genomic Variantsfor TRPM5 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 11 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for TRPM5 (2425745 - 2444275 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 3 variations for TRPM5 3 CNVs : 71238 29895 29896
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TRPM5
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Disorders
/ Diseasesfor TRPM5 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
TRPM5 for disorders About GeneDecksing
OMIM gene information: 604600
OMIM disorders : --4 diseases for TRPM5 : About MalaCards beckwith-wiedemann syndrome wilms tumor rhabdomyosarcoma prostatitis Human Genome Epidemiology (HuGE) Navigator: TRPM5 (4 documents) Export disorders for TRPM5 gene to outside databases
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Publicationsfor TRPM5 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TRPM5 gene, integrated from 9 sources (see all 16 ): (articles sorted by number of sources associating them with TRPM5) Utopia : connect your pdf to the dynamic world of online information
Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele- specific expression. (PubMed id 10607831) 1 , 2 , 3 Prawitt D.... Zabel B. (2000) International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. (PubMed id 16382100) 1 , 3 Clapham D.E....Schultz G. (2005) TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i. (PubMed id 14634208) 1 , 2 Prawitt D....Penner R. (2003) Genetic variation within the TRPM5 locus associates w ith prediabetic phenotypes in subjects at increased risk for type 2 diabetes. (PubMed id 21489577) 1 Ketterer C....Staiger H. (2011) Overexpression of human transient receptor potential M5 upregulates endogenous human transient receptor potential A1 in a stable HEK cell line. (PubMed id 21133676) 1 Buber M.T....Lee S.P. (2010) Association between common variation in genes encodin g sweet taste signaling components and human sucrose perception. (PubMed id 20660057) 1 Fushan A.A....Drayna D. (2010) Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279) 1 Hosgood H.D....Lan Q. (2009) TRPM5 and taste transduction. (PubMed id 17217064) 1 Liman E.R. (2007) Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811) 2 Taylor T.D....Sakaki Y. (2006) Extracellular acid block and acid-enhanced inactivation of the Ca2+-activated cation channel TRPM5 involve residues in the S3-S4 and S5-S6 extracellular domains. (PubMed id 15731110) 1 Liu D....Liman E.R. (2005)
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External Searches for TRPM5 gene
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Specialized Databases showing TRPM5 gene (According to PharmGKB ,
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About This Section Patent Information for TRPM5 gene: Search GeneIP for patents involving TRPM5 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TRPM5 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for TRPM5 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TRPM5 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TRPM5 OriGene Protein Over-expression Lysate for TRPM5 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TRPM5 OriGene 3'-UTR Clone for TRPM5 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TRPM5 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TRPM5 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TRPM5 OriGene Custom Protein Services for TRPM5 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRPM5 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TRPM5 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRPM5 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TRPM5 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TRPM5 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TRPM5
Search Tocris compounds for TRPM5
TRPM5 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPM5
ThermoFisher Antibodies for TRPM5
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TRPM5
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