TRPM4 Gene
protein-coding GIFtS: 53
GCID: GC19P049661
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transient receptor potential cation channel, subfamily M,...
| |
Aliases
for TRPM4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transient Receptor Potential Cation Channel, Subfamily M, Member 41 2 | | TRPM4B2 | | Calcium-Activated Non-Selective Cation Channel 12 3 | | Melastatin-43 | | Long Transient Receptor Potential Channel 42 3 | | Transient Receptor Potential Cation Channel Subfamily M Member 42 | | LTrpC42 3 | | LTRPC43 | | HTRPM41 | | LTrpC-43 | | PFHB1B2 5 | | Melastatin-43 | | FLJ200411 | | |
Export aliases for TRPM4 gene to outside databasesPrevious GC identifers: GC19P050319 GC19P050029 GC19P054337 GC19P054352 GC19P046037 |
Summaries
for TRPM4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TRPM4:
The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalentcations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases withincreasing intracellular calcium concentration, but this channel does not transport calcium. Two transcript variantsencoding different isoforms have been found for this gene. (provided by RefSeq, Aug 2010)
UniProtKB/Swiss-Prot: TRPM4_HUMAN, Q8TD43Function: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it isactivated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations(Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes,neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelialcells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyteactivation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebralarteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could causeirregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cellmotility and cytokine production through differential regulation of calcium signaling and NFATC1 localization.Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway
Gene Wiki entry for TRPM4
|
Genomic Views
for TRPM4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TRPM4 gene promoter:
Egr-3 AML1a MAZR p300 Bach2 AP-4 Arnt AREB6 ZID
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRPM4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRPM4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.33 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.3TRPM4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P049661: view genomic region
(about GC identifiers)
Start:
|
49,661,052 bp from pter |
End:
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49,715,093 bp from pter |
Size:
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54,042 bases |
Orientation:
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plus strand |
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Proteins
for TRPM4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TRPM4_HUMAN, Q8TD43 (See
protein sequence)Recommended Name: Transient receptor potential cation channel subfamily M member 4 Size: 1214 amino acids; 134301 Da
Subunit: Homomultimer
Subcellular location: Isoform 1: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum. Golgi apparatus
Subcellular location: Isoform 2: Endoplasmic reticulum. Golgi apparatus
Sequence caution: Sequence=BAA90907.1; Type=Erroneous termination; Positions=1191; Note=Translated as Glu;
Secondary accessions: A2RU25 Q7Z5D9 Q96L84 Q9NXV1Alternative splicing: 3 isoforms: Q8TD43-1 Q8TD43-2 Q8TD43-3 Explore the universe of human proteins at neXtProt for TRPM4: NX_Q8TD43
Post-translational modifications:
Phosphorylation by PKC leads to increase the sensitivity to Ca(2+)1
Sumoylated. Desumoylated by SENP11
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TD43
TRPM4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001182156.1 NP_060106.2
ENSEMBL proteins: ENSP00000252826 ENSP00000407492 ENSP00000347944
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
TRPM4 for ontologies About GeneDecksing
TRPM4 Antibody Products:
Assay Products for TRPM4: |
Protein
Domains /
Families
for TRPM4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRPM4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8TD43ProtoNet protein and cluster: Q8TD43 UniProtKB/Swiss-Prot: TRPM4_HUMAN, Q8TD43Similarity: Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM4 sub-subfamily |
Function
for TRPM4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TRPM4_HUMAN, Q8TD43Function: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it isactivated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations(Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes,neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelialcells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyteactivation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebralarteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could causeirregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cellmotility and cytokine production through differential regulation of calcium signaling and NFATC1 localization.Enhances cell proliferation through up-regulation of the beta-catenin signaling pathwayEnzyme regulation: Gating is voltage-dependent and repressed by decavanadate. Calmodulin-binding confers the Ca(2+)sensitivity. ATP is able to restore Ca(2+) sensitivity after desensitization. Phosphatidylinositol 4,5-bisphosphate(PIP2)-binding strongly enhances activity, by increasing the channel's Ca(2+) sensitivity and shifting its voltagedependence of activation towards negative potentials. Activity is also enhanced by 3,5-bis(trifluoromethyl)pyrazolederivative (BTP2)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRPM4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TRPM4 (NM_017636) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRPM4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPM4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPM4 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
TRPM4 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TRPM4:
Animal Models:
Mouse knock-outs for TRPM4: Trpm4tm1.1Knt Trpm4tm1.1Mfre
5 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Trpm4):
TRPM4 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TRPM4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Sodium channels and transporters: inward current | | | 2 | CREB Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for TRPM4
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TRPM4
TRPM4 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRPM4
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for TRPM4 (ENSP000002528264) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
TRPM4 for ontologies About GeneDecksing
|
Drugs & Compounds
for TRPM4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TRPM4 for compounds About GeneDecksing
 Browse Tocris compounds for TRPM4
1 HMDB Compound for TRPM4 About this table
1 Novoseek chemical compound relationship for TRPM4 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| calcium |
3.14 |
4 |
16407466 (2), 12699072 (1) |
Search CenterWatch for drugs/clinical trials and news about TRPM4
|
Transcripts
for TRPM4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TRPM4 gene (2 alternative transcripts): NM_001195227.1 NM_017636.3 Unigene Cluster for TRPM4: Transient receptor potential cation channel, subfamily M, member 4 Hs.467101 [show with all ESTs]Unigene Representative Sequence: NM_0176363 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000252826(uc002pmw.3 uc010yak.2 uc002pmx.3 uc010emv.3 uc010yal.2)
ENST00000427978(uc010emu.3) ENST00000355712(uc002pmy.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRPM4 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRPM4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TRPM4 (NM_017636) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRPM4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPM4 |
Additional cDNA sequence: AF497623.1 AJ575813.1 AK000048.1 AK000235.1 AK074664.1 AK292862.1 AK295820.1 AK307897.1 AY046396.1 AY297044.1 AY297045.1 AY297046.1 BC132727.1 BC144122.1 11 DOTS entries: DT.92062132 DT.100780303 DT.99927401 DT.101981811 DT.121489576 DT.121489602 DT.92012111 DT.95120904 DT.95186777 DT.121489564 DT.95183147 10 AceView cDNA sequences: NM_017636 AY297044 AY297045 AF497623 AJ575813 AK000235 AY297046 AY046396 AK074664 AK000048
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for TRPM4 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | · | 12d | ^ | 13 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26a | · | 26b |
|---|
|
| SP1: | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TRPM4
|
Expression
for TRPM4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRPM4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCGGCTCCT
About this image
See TRPM4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRPM4
SOURCE GeneReport for Unigene cluster: Hs.467101
UniProtKB/Swiss-Prot: TRPM4_HUMAN, Q8TD43Tissue specificity: Widely expressed with a high expression in intestine and prostate. In brain, it is both expressedin whole cerebral arteries and isolated vascular smooth muscle cells. Prominently expressed in Purkinje fibers.Expressed at higher levels in T-helper 2 (Th2) cells as compared to T-helper 1 (Th1) cells
SABiosciences Expression via Pathway-Focused PCR Array including TRPM4:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRPM4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRPM4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRPM4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRPM4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPM4 |
Orthologs
for TRPM4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TRPM4 gene from 5/15 species (see all 15) About this table
ENSEMBL Gene Tree for TRPM4 (if available)
TreeFam Gene Tree for TRPM4 (if available) |
Paralogs
for TRPM4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TRPM4 gene
- TRPM22 TRPM52 TRPM82 TRPM72 TRPM12 TRPM62 TRPM32
7 SIMAP similar genes for TRPM4 using alignment to 7 protein entries: TRPM4_HUMAN (see all proteins):TRPM5 TRPM2 MLSN2 TRPM8 TRPM3 TRPM6
TRPM7
TRPM4 for paralogs About GeneDecksing
|
Genomic Variants
for TRPM4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TRPM4 (49661052 - 49715093 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TRPM4
2 CNVs: 5109 32261
Human Gene Mutation Database (HGMD): TRPM4
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRPM4 |
|
Disorders
/ Diseases
for TRPM4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TRPM4 for disorders About GeneDecksing
OMIM gene information: 606936
OMIM disorders: 604559
UniProtKB/Swiss-Prot: TRPM4_HUMAN, Q8TD43
Defects in TRPM4 are the cause of progressive familial heart block type 1B (PFHB1B) [MIM:604559]. It is acardiac bundle branch disorder characterized by progressive alteration of cardiac conduction through the His-Purkinjesystem, with a pattern of a right bundle-branch block and/or left anterior hemiblock occurring individually ortogether. It leads to complete atrioventricular block causing syncope and sudden death
8  diseases for TRPM4: About MalaCardsprogressive familial heart block, type ib progressive familial heart block type 1b heart block conduction disease
cerebritis pancreatitis prostatitis neuronitis
2 diseases from the University of Copenhagen DISEASES database for TRPM4:Right bundle branch block Brugada syndrome Export disorders for TRPM4 gene to outside databases
|
Publications
for TRPM4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRPM4 gene, integrated from 9 sources (see all 39):
(articles sorted by number of sources associating them with TRPM4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform. (PubMed id 11535825)1, 2, 3, 9 Xu X.-Z.S.... Montell C. (2001)
- Cloning and characterization of rat transient recepto r potential-melastatin 4 (TRPM4). (PubMed id 19945433)1, 2, 9 Yoo J.C....Park J.Y. (2010)
- A pyrazole derivative potently inhibits lymphocyte Ca2+ influx and cytokine production by facilitating transient receptor potential melastatin 4 channel activity. (PubMed id 16407466)1, 2, 9 Takezawa R.... Penner R. (2006)
- TRPM5 is a voltage-modulated and Ca(2+)-activated monovalent selective cation channel. (PubMed id 12842017)1, 2, 9 Hofmann T.... Montell C. (2003)
- Mutational spectrum in the Ca(2+) -activated cation channel gene TRPM4 in patients with cardiac conductance disturbances. (PubMed id 21887725)1, 2 Stallmeyer B.... Schulze-Bahr E. (2011)
- TRPM4 enhances cell proliferation through up-regulati on of the I^-catenin signaling pathway. (PubMed id 20625999)1, 2 ArmisAcn R....Stutzin A. (2011)
- Gain-of-function mutations in TRPM4 cause autosomal d ominant isolated cardiac conduction disease. (PubMed id 20562447)1, 2 Liu H....Bouvagnet P. (2010)
- Impaired endocytosis of the ion channel TRPM4 is asso ciated with human progressive familial heart block type I. (PubMed id 19726882)1, 2 Kruse M....Pongs O. (2009)
- TRPM4 controls insulin secretion in pancreatic beta-cells. (PubMed id 16806463)1, 2 Cheng H.... Penner R. (2007)
- The Ca2+-activated cation channel TRPM4 is regulated by phosphatidylinositol 4,5-biphosphate. (PubMed id 16424899)1, 2 Nilius B.... Voets T. (2006)
|
External Searches for TRPM4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TRPM4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRPM4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TRPM4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TRPM4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TRPM4 gene:
Search GeneIP for patents involving TRPM4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TRPM4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for TRPM4 | | OriGene shRNA RFP for TRPM4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRPM4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRPM4 | | | OriGene Protein Over-expression Lysate for TRPM4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TRPM4 | | OriGene 3'-UTR Clone for TRPM4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRPM4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRPM4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TRPM4 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TRPM4 | | OriGene Custom Protein Services for TRPM4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRPM4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRPM4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRPM4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRPM4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRPM4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRPM4 |
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| | | | Search Tocris compounds for TRPM4 |
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 | | | TRPM4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPM4 |
|  |  |  | | | | ThermoFisher Antibodies for TRPM4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPM4 |
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