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Aliases for TRPM3 Gene

Aliases for TRPM3 Gene

  • Transient Receptor Potential Cation Channel Subfamily M Member 3 2 3 5
  • Long Transient Receptor Potential Channel 3 3 4
  • Melastatin-2 3 4
  • LTrpC-3 3 4
  • LTRPC3 3 4
  • MLSN2 3 4
  • Transient Receptor Potential Cation Channel, Subfamily M, Member 3 2
  • Melastatin 2 2
  • EC 5.99.1.3 61
  • EC 2.3.1.31 61
  • KIAA1616 4
  • GON-2 3

External Ids for TRPM3 Gene

Previous GeneCards Identifiers for TRPM3 Gene

  • GC09M064194
  • GC09M065245
  • GC09M066720
  • GC09M068607
  • GC09M070380
  • GC09M072339
  • GC09M073149
  • GC09M042990

Summaries for TRPM3 Gene

Entrez Gene Summary for TRPM3 Gene

  • The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRPM3 Gene

TRPM3 (Transient Receptor Potential Cation Channel Subfamily M Member 3) is a Protein Coding gene. Diseases associated with TRPM3 include Dentin Sensitivity. Among its related pathways are Ion channel transport and CREB Pathway. GO annotations related to this gene include ion channel activity and cation channel activity. An important paralog of this gene is TRPM1.

UniProtKB/Swiss-Prot for TRPM3 Gene

  • Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation.

Gene Wiki entry for TRPM3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRPM3 Gene

Genomics for TRPM3 Gene

Regulatory Elements for TRPM3 Gene

Enhancers for TRPM3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F070599 1.6 FANTOM5 Ensembl ENCODE 6.9 +845.5 845490 3.2 FEZF1 YY1 GLIS2 ZNF143 FOS TSHZ1 REST ATF4 GLIS1 WT1 SMC5 PTAR1 KLF9 TRPM3 GC09P070607 RN7SL726P
GH09F071692 0.6 ENCODE 9.6 -245.6 -245596 0.2 RAD21 ZFHX2 MAFF ZNF316 ATF3 MAFK EMSY EGR2 ZBTB20 TRPM3 GC09P071678 LOC100420790
GH09F070608 0.6 ENCODE 8.9 +837.3 837303 1.5 JUND BHLHE40 FOS MAFK ATF2 KLF9 TRPM3 GC09P070607 GC09P070646
GH09F070923 0.9 Ensembl ENCODE 5.7 +522.2 522209 1.5 CTCF ZNF654 PKNOX1 ZNF2 RAD21 SMC3 FOS PRDM1 TRPM3 GC09P070931 PIGUP1
GH09F071690 0.5 Ensembl 9.8 -243.7 -243677 0.4 JUND ATF3 FOS MAFK TRPM3 GC09P071678 LOC100420790
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRPM3 on UCSC Golden Path with GeneCards custom track

Promoters for TRPM3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001305407 23 1400 CTCF SAP130 MAX SIN3A ZSCAN9 ZIC2 RAD21 GLIS2 ZBTB48 PATZ1

Genomic Location for TRPM3 Gene

Chromosome:
9
Start:
70,529,063 bp from pter
End:
71,446,924 bp from pter
Size:
917,862 bases
Orientation:
Minus strand

Genomic View for TRPM3 Gene

Genes around TRPM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRPM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRPM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRPM3 Gene

Proteins for TRPM3 Gene

  • Protein details for TRPM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCF6-TRPM3_HUMAN
    Recommended name:
    Transient receptor potential cation channel subfamily M member 3
    Protein Accession:
    Q9HCF6
    Secondary Accessions:
    • A2A3F6
    • A9Z1Y7
    • Q5VW02
    • Q5VW03
    • Q5VW04
    • Q5W5T7
    • Q86SH0
    • Q86SH6
    • Q86UL0
    • Q86WK1
    • Q86WK2
    • Q86WK3
    • Q86WK4
    • Q86YZ9
    • Q86Z00
    • Q86Z01
    • Q9H0X2

    Protein attributes for TRPM3 Gene

    Size:
    1732 amino acids
    Molecular mass:
    197571 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB66480.2; Type=Miscellaneous discrepancy; Note=Cloning artifact in C-terminus.; Evidence={ECO:0000305}; Sequence=CAM13096.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAM13169.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAM15782.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAM17596.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAM22746.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TRPM3 Gene

neXtProt entry for TRPM3 Gene

Selected DME Specific Peptides for TRPM3 Gene

Q9HCF6:
  • RLTGLER
  • VARQAIL

Post-translational modifications for TRPM3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for TRPM3 Gene

Gene Families for TRPM3 Gene

Protein Domains for TRPM3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HCF6

UniProtKB/Swiss-Prot:

TRPM3_HUMAN :
  • Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM3 sub-subfamily.
Family:
  • Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM3 sub-subfamily.
genes like me logo Genes that share domains with TRPM3: view

Function for TRPM3 Gene

Molecular function for TRPM3 Gene

UniProtKB/Swiss-Prot Function:
Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation.

Enzyme Numbers (IUBMB) for TRPM3 Gene

Gene Ontology (GO) - Molecular Function for TRPM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005227 calcium activated cation channel activity IEA --
GO:0005261 cation channel activity IEA,IDA 15824111
GO:0005262 calcium channel activity TAS --
genes like me logo Genes that share ontologies with TRPM3: view
genes like me logo Genes that share phenotypes with TRPM3: view

Animal Models for TRPM3 Gene

MGI Knock Outs for TRPM3:

Animal Model Products

  • Taconic Biosciences Mouse Models for TRPM3

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRPM3 Gene

Localization for TRPM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRPM3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRPM3 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
extracellular 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TRPM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TRPM3: view

Pathways & Interactions for TRPM3 Gene

genes like me logo Genes that share pathways with TRPM3: view

Pathways by source for TRPM3 Gene

Interacting Proteins for TRPM3 Gene

Gene Ontology (GO) - Biological Process for TRPM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006812 cation transport IEA,IDA 15824111
GO:0006816 calcium ion transport IEA --
GO:0007216 G-protein coupled glutamate receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with TRPM3: view

No data available for SIGNOR curated interactions for TRPM3 Gene

Drugs & Compounds for TRPM3 Gene

(16) Drugs for TRPM3 Gene - From: DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mefenamic acid Approved Pharma Activator, inhibitor Anti-inflammatory agent 7
Nifedipine Approved Pharma Antagonist, Gating inhibitor, blocker 112
Pioglitazone Approved, Investigational Pharma Full agonist, Agonist, agonist 435
Rosiglitazone Approved, Investigational Pharma Full agonist, Agonist, agonist Potent PPARγ agonist, Potent and selective PPARgamma agonist; antidiabetic agent. 220
Sphingosine Experimental Pharma 0

(2) Additional Compounds for TRPM3 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
D-erythrosphingosine
Activator
dihydro-D-erythrosphingosine
Activator
genes like me logo Genes that share compounds with TRPM3: view

Transcripts for TRPM3 Gene

Unigene Clusters for TRPM3 Gene

Transient receptor potential cation channel, subfamily M, member 3:
Representative Sequences:

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRPM3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - -
SP9: - - - -
SP10: -
SP11: - -
SP12: -
SP13: - -

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31a · 31b
SP1: - -
SP2: -
SP3: -
SP4: -
SP5: -
SP6:
SP7: -
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for TRPM3 Gene

GeneLoc Exon Structure for
TRPM3
ECgene alternative splicing isoforms for
TRPM3

Expression for TRPM3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRPM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRPM3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.4) and Brain - Cerebellum (x5.9).

Protein differential expression in normal tissues from HIPED for TRPM3 Gene

This gene is overexpressed in Kidney (35.8), Fetal gut (20.0), and Spinal cord (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRPM3 Gene



Protein tissue co-expression partners for TRPM3 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRPM3 Gene:

TRPM3

SOURCE GeneReport for Unigene cluster for TRPM3 Gene:

Hs.47288

mRNA Expression by UniProt/SwissProt for TRPM3 Gene:

Q9HCF6-TRPM3_HUMAN
Tissue specificity: Expressed primarily in the kidney and, at lower levels, in brain, testis, ovary, pancreas and spinal cord. Expression in the brain and kidney was determined at protein level. In the kidney, expressed predominantly in the collecting tubular epithelium in the medulla, medullary rays, and periglomerular regions; in the brain, highest levels are found in the cerebellum, choroid plexus, the locus coeruleus, the posterior thalamus and the substantia nigra. Down-regulated in renal tumors compared to normal kidney.
genes like me logo Genes that share expression patterns with TRPM3: view

Primer Products

Orthologs for TRPM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRPM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRPM3 34 35
  • 99.72 (n)
oppossum
(Monodelphis domestica)
Mammalia TRPM3 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRPM3 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRPM3 34 35
  • 93.18 (n)
rat
(Rattus norvegicus)
Mammalia Trpm3 34
  • 91.69 (n)
mouse
(Mus musculus)
Mammalia Trpm3 34 16 35
  • 91.5 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TRPM3 35
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRPM3 34 35
  • 81.53 (n)
lizard
(Anolis carolinensis)
Reptilia TRPM3 35
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trpm3 34
  • 76.68 (n)
zebrafish
(Danio rerio)
Actinopterygii trpm3 34 35
  • 72.94 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006825 34
  • 56.87 (n)
fruit fly
(Drosophila melanogaster)
Insecta trpm 34
  • 56.63 (n)
Species where no ortholog for TRPM3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRPM3 Gene

ENSEMBL:
Gene Tree for TRPM3 (if available)
TreeFam:
Gene Tree for TRPM3 (if available)

Paralogs for TRPM3 Gene

Paralogs for TRPM3 Gene

genes like me logo Genes that share paralogs with TRPM3: view

Variants for TRPM3 Gene

Sequence variations from dbSNP and Humsavar for TRPM3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs767146880 Pathogenic 70,810,048(+) ACAAA(A/C/G)GGAAG intron-variant, nc-transcript-variant
rs193921019 Uncertain significance 70,598,652(-) AGCCA(A/G)GGAAG intron-variant, reference, missense
rs10081686 -- 70,831,457(+) TTGTA(A/G)GTGTA intron-variant, upstream-variant-2KB
rs10081694 -- 70,831,126(+) TAACT(G/T)CCCAA intron-variant, upstream-variant-2KB
rs10081739 -- 71,293,595(+) ATATA(C/T)TACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRPM3 Gene

Variant ID Type Subtype PubMed ID
dgv4066n106 CNV deletion 24896259
dgv72n64 CNV loss 17921354
esv1118924 CNV deletion 17803354
esv1341286 CNV insertion 17803354
esv1692487 CNV deletion 17803354
esv1931744 CNV deletion 18987734
esv22135 CNV loss 19812545
esv2540002 CNV insertion 19546169
esv2572392 CNV deletion 19546169
esv2659014 CNV deletion 23128226
esv26755 CNV loss 19812545
esv2738542 CNV deletion 23290073
esv3305116 CNV mobile element insertion 20981092
esv3326854 CNV insertion 20981092
esv3340007 CNV insertion 20981092
esv3348557 CNV insertion 20981092
esv3354373 CNV insertion 20981092
esv3369324 CNV insertion 20981092
esv3381927 CNV insertion 20981092
esv3544889 CNV deletion 23714750
esv3573259 CNV loss 25503493
esv3620580 CNV loss 21293372
esv3620584 CNV loss 21293372
esv3620588 CNV loss 21293372
esv3620590 CNV loss 21293372
esv3620591 CNV loss 21293372
esv3620593 CNV loss 21293372
esv3620594 CNV loss 21293372
esv7523 CNV loss 19470904
esv8273 CNV gain 19470904
esv999856 CNV deletion 20482838
nsv1043383 CNV gain 25217958
nsv1075247 CNV deletion 25765185
nsv1117889 CNV deletion 24896259
nsv428219 CNV loss 18775914
nsv442152 CNV loss 18776908
nsv499504 CNV loss 21111241
nsv508551 CNV deletion 20534489
nsv510944 OTHER complex 20534489
nsv516833 CNV loss 19592680
nsv521565 CNV loss 19592680
nsv614598 CNV loss 21841781
nsv6556 CNV deletion 18451855
nsv6557 CNV insertion 18451855
nsv6558 CNV deletion 18451855
nsv831616 CNV gain 17160897
nsv951526 CNV deletion 24416366

Variation tolerance for TRPM3 Gene

Residual Variation Intolerance Score: 2.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.35; 94.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRPM3 Gene

Human Gene Mutation Database (HGMD)
TRPM3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRPM3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRPM3 Gene

Disorders for TRPM3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRPM3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
dentin sensitivity
  • sensitive dentin
- elite association - COSMIC cancer census association via MalaCards
Search TRPM3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TRPM3

Genetic Association Database (GAD)
TRPM3
Human Genome Epidemiology (HuGE) Navigator
TRPM3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRPM3
genes like me logo Genes that share disorders with TRPM3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRPM3 Gene

Publications for TRPM3 Gene

  1. Expression and characterization of human transient receptor potential melastatin 3 (hTRPM3). (PMID: 12672827) Lee N. … Blanar M.A. (J. Biol. Chem. 2003) 3 4 22 64
  2. Pregnenolone sulphate- and cholesterol-regulated TRPM3 channels coupled to vascular smooth muscle secretion and contraction. (PMID: 20360246) Naylor J. … Beech D.J. (Circ. Res. 2010) 3 22 64
  3. Joint influence of small-effect genetic variants on human longevity. (PMID: 20834067) Yashin A.I. … Ukraintseva S.V. (Aging (Albany NY) 2010) 3 46 64
  4. Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease. (PMID: 20855565) Peloso G.M. … Brousseau M.E. (J. Lipid Res. 2010) 3 46 64
  5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64

Products for TRPM3 Gene

Sources for TRPM3 Gene

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