Aliases for TRPM2 Gene
External Ids for TRPM2 Gene
Previous HGNC Symbols for TRPM2 Gene
Previous GeneCards Identifiers for TRPM2 Gene
The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]
GeneCards Summary for TRPM2 Gene
TRPM2 (Transient Receptor Potential Cation Channel, Subfamily M, Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and L1CAM interactions. GO annotations related to this gene include calcium channel activity and manganese ion transmembrane transporter activity. An important paralog of this gene is TRPM1.
UniProtKB/Swiss-Prot for TRPM2 Gene
Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity.