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TRPM2 Gene

protein-coding   GIFtS: 64
GCID: GC21P045770

Transient Receptor Potential Cation Channel, Subfamily M,...


(Previous symbol: TRPC7)
  Search for TRPM2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transient Receptor Potential Cation Channel, Subfamily M, Member 21 2     LTrpC-22 3
TRPC71 2 3 5     NUDT9H2
KNP32 3 5     NUDT9L12
Estrogen-Responsive Element-Associated Gene 1 Protein2 3     Transient Receptor Potential Cation Channel Subfamily M Member 22
Long Transient Receptor Potential Channel 22 3     EC 3.6.1.133
Transient Receptor Potential Channel 72 3     LTrpC23
EREG12 3     TrpC73
LTRPC22 3     

External Ids:    HGNC: 123391   Entrez Gene: 72262   Ensembl: ENSG000001421857   OMIM: 6037495   UniProtKB: O947593   

Export aliases for TRPM2 gene to outside databases

Previous GC identifers: GC21P042282 GC21P044629 GC21P044597 GC21P031143


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRPM2 Gene:
The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular
ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death.
Several alternatively spliced transcript variants of this gene have been described, but their full-length nature
is not known. (provided by RefSeq, Jul 2008)

GeneCards Summary for TRPM2 Gene:
TRPM2 (transient receptor potential cation channel, subfamily M, member 2) is a protein-coding gene. GO annotations related to this gene include manganese ion transmembrane transporter activity and calcium channel activity. An important paralog of this gene is TRPM5.

UniProtKB/Swiss-Prot: TRPM2_HUMAN, O94759
Function: Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to
oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a
positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)),
reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell
death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase
activity

Gene Wiki entry for TRPM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRPM2 gene promoter:
         Spz1   AML1a   HSF1 (long)   STAT5A   NF-kappaB   YY1   NF-kappaB2   c-Myb   HSF1short   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRPM2 promoter sequence
   Search Chromatin IP Primers for TRPM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRPM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3

TRPM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRPM2 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21P045770:  view genomic region     (about GC identifiers)

Start:
45,770,046 bp from pter      End:
45,862,964 bp from pter
Size:
92,919 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for TRPM2

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRPM2_HUMAN, O94759 (See protein sequence)
Recommended Name: Transient receptor potential cation channel subfamily M member 2  
Size: 1503 amino acids; 171198 Da
Subunit: Isoform 1 can interact with isoform 3. This interaction decreases calcium influx through isoform 1 and
suppresses susceptibility to oxidative stress-induced cell death
Sequence caution: Sequence=BAB64300.1; Type=Frameshift; Positions=1227, 1237;
Secondary accessions: D3DSL6 Q5KTC2 Q6J3P5 Q96KN6 Q96Q93
Alternative splicing: 3 isoforms:  O94759-1   O94759-2   O94759-3   

Explore the universe of human proteins at neXtProt for TRPM2: NX_O94759

Explore proteomics data for TRPM2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys307
  • Modification sites at PhosphoSitePlus

  • See TRPM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003298.1  
    ENSEMBL proteins: 
     ENSP00000300482   ENSP00000393982   ENSP00000381023   ENSP00000381026   ENSP00000300481  
    Reactome Protein details: O94759

    TRPM2 Human Recombinant Protein Products:

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    Novus Biologicals TRPM2 Proteins
    Novus Biologicals TRPM2 Lysate
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    Cloud-Clone Corp. Proteins for TRPM2

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TRP: Voltage-gated ion channels / Transient receptor potential cation channels
    NUDT: Nudix motif containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: TRPM2
    Transient Receptor Potential channels

    3 InterPro protein domains:
     IPR015797 NUDIX_hydrolase_dom-like
     IPR005821 Ion_trans_dom
     IPR000086 NUDIX_hydrolase_dom

    Graphical View of Domain Structure for InterPro Entry O94759

    ProtoNet protein and cluster: O94759

    2 Blocks protein domains:
    IPB000086 NUDIX hydrolase
    IPB002153 Transient receptor potential family signature


    UniProtKB/Swiss-Prot: TRPM2_HUMAN, O94759
    Similarity: Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily
    Similarity: Contains 1 nudix hydrolase domain


    Find genes that share domains with TRPM2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRPM2_HUMAN, O94759
    Function: Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to
    oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a
    positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)),
    reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell
    death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase
    activity
    Catalytic activity: ADP-D-ribose + H(2)O = AMP + D-ribose 5-phosphate
    Biophysicochemical properties: Kinetic parameters: KM=100 uM for ADP-ribose; Vmax=0.1 umol/min/mg enzyme;
    Induction: NAD(+)

         Enzyme Number (IUBMB): EC 3.6.1.131

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005262calcium channel activity IEA--
    GO:0005272sodium channel activity IEA--
    GO:0005384manganese ion transmembrane transporter activity IEA--
    GO:0016787hydrolase activity ----
         
    Find genes that share ontologies with TRPM2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TRPM2:
     Synthetic lethal with Ras 

         8 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Trpm2):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging  muscle 

    Find genes that share phenotypes with TRPM2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TRPM2: Trpm2tm1Yamo Trpm2tm1.1Jych

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRPM2
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRPM2

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    miRTarBase miRNAs that target TRPM2:
    hsa-mir-423-3p (MIRT042627)

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    2 qRT-PCR Assays for microRNAs that regulate TRPM2:
    hsa-miR-3184 hsa-miR-423-5p
    SwitchGear 3'UTR luciferase reporter plasmidTRPM2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRPM2_HUMAN, O94759: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytoskeleton1
    cytosol1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9806837
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with TRPM2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TRPM2 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58
    2CREB Pathway
    Intracellular Calcium Signaling0.50
    3Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    4Oxytocin signaling pathway
    Oxytocin signaling pathway0.32
    5TRP channels
    TRP channels


    Find genes that share SuperPaths with TRPM2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TRPM2
        Intracellular Calcium Signaling

    1 Reactome Pathway for TRPM2
        TRP channels


    1 Kegg Pathway  (Kegg details for TRPM2):
        Oxytocin signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including TRPM2: 
              Neuronal Ion Channels in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TRPM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for TRPM2 (O947593 ENSP000003004824) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRPC6Q9Y2103, ENSP000003409134I2D: score=1 STRING: ENSP00000340913
    ITPR3Q145733, ENSP000003634354I2D: score=2 STRING: ENSP00000363435
    CLUENSP000003151304STRING: ENSP00000315130
    H2AFXENSP000003643104STRING: ENSP00000364310
    TNIKENSP000003995114STRING: ENSP00000399511
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0006816calcium ion transport TAS9806837
    GO:0006828manganese ion transport ----
    GO:0033194response to hydroperoxide IEA--
    GO:0034220ion transmembrane transport TAS--

    Find genes that share ontologies with TRPM2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRPM2

    3 HMDB Compounds for TRPM2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    SodiumSodium (see all 2)7440-23-5--

    Selected IUPHAR Ligands for TRPM2 (TRPM2) (see all 16)    About this table
    LigandTypeActionAffinityPubmed IDs
    2-APB
    Pore BlockerAntagonist6.118204483
    Zn2+
    Channel blockerNone6--
    ACAA
    Pore BlockerAntagonist5.816604090
    NAADP
    ActivatorAgonist3.116585058
    clotrimazole
    Pore BlockerAntagonist3.115549272
    miconazole
    Pore BlockerAntagonist3.118204483
    NAD
    ActivatorAgonist3.116601673 12564954 11804595 11509734
    flufenamic acid
    Pore BlockerAntagonist3.115275834 18204483
    arachidonic acid
    ActivatorPotentiation3.1--
    Ca2+
    ActivatorNone3.1--

    7 Novoseek inferred chemical compound relationships for TRPM2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adpribose 90.6 82 16585058 (5), 18572241 (5), 15347676 (4), 16604090 (4) (see all 25)
    flufenamic acid 79.1 7 15275834 (3), 18204483 (1), 19124544 (1)
    nad+ 51.7 4 11804595 (1), 16565078 (1), 15275834 (1)
    h2o2 46.9 24 18048770 (4), 16651700 (4), 11804595 (2), 16604090 (2) (see all 10)
    calcium 45.5 27 12529379 (4), 18048770 (4), 11804595 (3), 16651700 (3) (see all 10)
    oxygen 18.8 4 15708008 (1), 20194125 (1), 11804595 (1), 19124544 (1)
    estrogen 0 1 8252481 (1)



    Find genes that share compounds with TRPM2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRPM2 gene (2 alternative transcripts): 
    NM_003307.3  NM_001001188.3  

    Unigene Cluster for TRPM2:

    Transient receptor potential cation channel, subfamily M, member 2
    Hs.369759  [show with all ESTs]
    Unigene Representative Sequence: AB166745
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300482(uc002zet.1 uc021wjr.1 uc002zew.1 uc010gpt.1)
    ENST00000431901 ENST00000397928(uc002zeu.1) ENST00000397932 ENST00000300481
    ENST00000498430(uc002zex.1 uc002zey.1 uc011aff.1) ENST00000490982

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    SwitchGear 3'UTR luciferase reporter plasmidTRPM2 3' UTR sequence
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    Additional mRNA sequence: 

    AB166745.1 AB166746.1 AJ878416.1 AK301101.1 AK301451.1 AY603182.1 BC112342.1 EU362987.1 
    NR_038257.1 

    7 DOTS entries:

    DT.407683  DT.100746078  DT.121142606  DT.121142614  DT.121142616  DT.121142622  DT.121142609 

    Selected AceView cDNA sequences (see all 91):

    BC041570 AW292642 BE535510 BQ276462 NM_003307 CD616816 AI971759 BM795023 
    BU543741 BQ722994 BI906484 NM_001001188 BF064117 AI739196 AI380559 BU179127 
    BG774493 AW206669 BI755424 BM353615 BG719129 BM793165 BU173730 AB001535 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TRPM2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a ·
    SP1:                                                                                                                                -                           
    SP2:                                                                                                                                                            
    SP3:        -                                                                                                                                                   
    SP4:                                                                                                                                            -               
    SP5:                                                                                                                                                            

    ExUns: 23b ^ 24a · 24b ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b
    SP1:        -                                                                                 
    SP2:                                                  -                                       
    SP3:                                                                                          
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for TRPM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRPM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGGGTTTG
    TRPM2 Expression
    About this image


    TRPM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Thymus (Hematopoietic System)
             Thymus
    TRPM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRPM2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.369759

    UniProtKB/Swiss-Prot: TRPM2_HUMAN, O94759
    Tissue specificity: Highly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in
    bone marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes

        Pathway & Disease-focused RT2 Profiler PCR Array including TRPM2: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TRPM2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trpm21 , 5 transient receptor potential cation channel, subfamily more1, 5 83.5(n)1
    85.66(a)1
      10 (39.72 cM)5
    282401  NM_138301.21  NP_612174.21 
     779077225 
    chicken
    (Gallus gallus)
    Aves TRPM21 transient receptor potential cation channel, subfamily more 76.27(n)
    74.8(a)
      424835  XM_004937024.1  XP_004937081.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRPM26
    transient receptor potential cation channel, subfa...
    75(a)
    1 ↔ 1
    3(33699172-33744819)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia trpm21 transient receptor potential cation channel, subfamily more 64.05(n)
    68.34(a)
      100124999  NM_001102927.1  NP_001096397.1 
    zebrafish
    (Danio rerio)
    Actinopterygii trpm26
    transient receptor potential cation channel, subfa...
    51(a)
    1 ↔ 1
    9(54455663-54745644) ENSDARG00000060567
    fruit fly
    (Drosophila melanogaster)
    Insecta trpm6
    --
    20(a)
    1 → many
    2R(11150309-11180386)
    worm
    (Caenorhabditis elegans)
    Secernentea gtl-26
    gtl-16
    (see all 3)
    Protein GTL-1 (gtl-1) mRNA, complete cds
    (see all 3)
    25(a)
    20(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    IV(11273483-11281924) WBGene00001796
    IV(11248902-11259465) WBGene00001795


    ENSEMBL Gene Tree for TRPM2 (if available)
    TreeFam Gene Tree for TRPM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRPM2 gene
    TRPM52  TRPM82  TRPM72  TRPM62  TRPM12  TRPM32  TRPM42  
    7 SIMAP similar genes for TRPM2 using alignment to 6 protein entries:     TRPM2_HUMAN (see all proteins):
    TRPM8    MLSN2    TRPM5    TRPM3    TRPM4    TRPM6
    NUDT9

    Find genes that share paralogs with TRPM2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRPM2 (see all 3010)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1466912291,2
    Cuntested145819276(+) CAGCTC/TGCCCT 3 L syn11Minor allele frequency- T:0.00NA 4544
    rs1810641431,2
    --45771503(+) AAGAAC/TCCCAG 2 -- us2k10--------
    rs1841388071,2
    --45771537(+) AGGTCA/GTTGCC 2 -- us2k10--------
    rs1164787501,2
    F--45771592(+) GCACCC/TGTCCT 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs9288541,2
    C,H--45771629(+) CCCCCC/GACAGC 2 -- us2k17Minor allele frequency- G:0.00NA NS EA 444
    rs284278781,2
    C,F--45771845(+) ACCGTG/AGACCC 2 -- us2k110Minor allele frequency- A:0.08NS NA WA CSA 322
    rs1894036261,2
    C--45771954(+) CCTTGC/TGGTGC 2 -- us2k10--------
    rs287100321,2
    --45772016(+) TGCCCA/CTCTGC 2 -- us2k10--------
    rs455782371,2
    C,F--45772040(+) TGGTTG/CTGAAG 2 -- us2k15Minor allele frequency- C:0.01NS 186
    rs454537941,2
    C,F--45772062(+) GCTGCG/AGGGAC 2 -- us2k16Minor allele frequency- A:0.05NS WA 302

    HapMap Linkage Disequilibrium report for TRPM2 (45770046 - 45862964 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TRPM2 (see all 47):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2636773CNV Deletion19546169
    esv2723657CNV Deletion23290073
    esv1196219CNV Deletion17803354
    esv3375CNV Deletion18987735
    esv2299983CNV Deletion18987734
    esv2310692CNV Deletion18987734
    esv1217346CNV Deletion17803354
    esv2723653CNV Deletion23290073
    esv1238729CNV Deletion17803354
    esv1585847CNV Deletion17803354

    Human Gene Mutation Database (HGMD): TRPM2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRPM2
    DNA2.0 Custom Variant and Variant Library Synthesis for TRPM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603749    OMIM disorders: --


    Find genes that share disorders with TRPM2           About GenesLikeMe

    3 Novoseek inferred disease relationships for TRPM2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 0 1 8252481 (1)
    breast cancer 0 2 8252481 (2)
    tumors 0 8 8252481 (4)

    Genetic Association Database (GAD): TRPM2
    Human Genome Epidemiology (HuGE) Navigator: TRPM2 (39 documents)

    Export disorders for TRPM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRPM2 gene, integrated from 10 sources (see all 105):
    (articles sorted by number of sources associating them with TRPM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. (PubMed id 11385575)1, 2, 3 Perraud A.-L....Scharenberg A.M. (Nature 2001)
    2. Molecular cloning of a novel putative Ca2+ channel protein (TRPC7) highly expressed in brain. (PubMed id 9806837)1, 2, 3 Nagamine K....Shimizu N. (Genomics 1998)
    3. A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death. (PubMed id 12594222)1, 2, 9 Zhang W....Miller B.A. (J. Biol. Chem. 2003)
    4. Characterization of human and mouse TRPM2 genes: identification of a novel N-terminal truncated protein specifically expressed in human striatum. (PubMed id 15708008)1, 2, 9 Uemura T.... Shimizu N. (Biochem. Biophys. Res. Commun. 2005)
    5. LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. (PubMed id 11804595)1, 2, 9 Hara Y.... Mori Y. (Mol. Cell 2002)
    6. Gene variation of the transient receptor potential cation channel, subfamily M, member 2 (TRPM2) and type 2 diabetes mellitus: A case-control study. (PubMed id 20515676)1, 4 Romero J.R....Zee R.Y. ( international journal of clinical chemistry 2010)
    7. TRPM2 variants and bipolar disorder risk: confirmation in a family-based association study. (PubMed id 19133961)1, 4 Xu C....Warsh J.J. (Bipolar Disord 2009)
    8. Candidate gene analysis of 21q22: support for S100B as a susceptibility gene for bipolar affective disorder with psychosis. (PubMed id 17525977)1, 4 Roche S....McKeon P. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
    9. Association of the putative susceptibility gene, transient receptor potential protein melastatin type 2, with bipolar disorder. (PubMed id 16252251)1, 4 Xu C....Warsh J.J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2006)
    10. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. (PubMed id 16382100)1, 3 Clapham D.E....Schultz G. (Pharmacol. Rev. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7226 HGNC: 12339 AceView: TRPM2 Ensembl:ENSG00000142185 euGenes: HUgn7226
    ECgene: TRPM2 Kegg: 7226 H-InvDB: TRPM2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRPM2 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/trpm2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRPM2 gene:
    Search GeneIP for patents involving TRPM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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