Aliases for TRPM2 Gene
- Transient Receptor Potential Cation Channel Subfamily M Member 2 2 3
- Transient Receptor Potential Cation Channel, Subfamily M, Member 2 2 3 5
- Estrogen-Responsive Element-Associated Gene 1 Protein 3 4
- Long Transient Receptor Potential Channel 2 3 4
- Transient Receptor Potential Channel 7 3 4
- LTrpC-2 3 4
- LTRPC2 3 4
External Ids for TRPM2 Gene
Previous HGNC Symbols for TRPM2 Gene
Previous GeneCards Identifiers for TRPM2 Gene
The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2016]
GeneCards Summary for TRPM2 Gene
TRPM2 (Transient Receptor Potential Cation Channel Subfamily M Member 2) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include hydrolase activity and calcium channel activity. An important paralog of this gene is TRPM1.
UniProtKB/Swiss-Prot for TRPM2 Gene
Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity.