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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TRPM2 Gene

protein-coding GIFtS: 61
GCID: GC21P045770

transient receptor potential cation channel, subfamily M,...

(Previous symbol: TRPC7)

Explore 8 diseases affiliated with
TRPM2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Transient Receptor Potential Cation Channel, Subfamily M, Member 2¹ ²		Long Transient Receptor Potential Channel 2² ³
KNP3¹ ² ³ ⁵		Transient Receptor Potential Channel 7² ³
TRPC7¹ ² ³ ⁵		LTrpC-2² ³
EREG1¹ ² ³		Transient Receptor Potential Cation Channel Subfamily M Member 2²
LTRPC2¹ ² ³		EC 3.6.1.13³
NUDT9H¹ ²		LTrpC2³
NUDT9L1¹ ²		TrpC7³
Estrogen-Responsive Element-Associated Gene 1 Protein² ³

External Ids:	HGNC: 12339¹	Entrez Gene: 7226²	Ensembl: ENSG00000142185⁷	OMIM: 603749⁵	UniProtKB: O94759³

ORGUL members:
	NONCODE:n410803

Export aliases for TRPM2 gene to outside databases

Previous GC identifers: GC21P042282 GC21P044629 GC21P044597 GC21P031143

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRPM2:

The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular

ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several

alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TRPM2_HUMAN, O94759

Function: Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to

oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive

regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive

nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death

following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity

Gene Wiki entry for TRPM2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000021.8 NC_018932.1 NT_011515.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TRPM2 gene promoter:
Spz1 AML1a HSF1 (long) STAT5A NF-kappaB YY1 NF-kappaB2 c-Myb HSF1short NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRPM2 promoter sequence

Search SABiosciences Chromatin IP Primers for TRPM2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRPM2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3 Ensembl cytogenetic band: 21q22.3 HGNC cytogenetic band: 21q22.3

TRPM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRPM2 gene location

GeneLoc information about chromosome 21 GeneLoc Exon Structure

GeneLoc location for GC21P045770: view genomic region (about GC identifiers)

Start:	45,770,046 bp from pter	End:	45,862,964 bp from pter
Size:	92,919 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TRPM2_HUMAN, O94759 (See protein sequence)

Recommended Name: Transient receptor potential cation channel subfamily M member 2

Size: 1503 amino acids; 171198 Da

Subunit: Isoform 1 can interact with isoform 3. This interaction decreases calcium influx through isoform 1 and

suppresses susceptibility to oxidative stress-induced cell death

Subcellular location: Membrane; Multi-pass membrane protein

Sequence caution: Sequence=BAB64300.1; Type=Frameshift; Positions=1227, 1237;

Secondary accessions: D3DSL6 Q5KTC2 Q6J3P5 Q96KN6 Q96Q93

Alternative splicing: 3 isoforms: O94759-1 O94759-2 O94759-3

Explore the universe of human proteins at neXtProt for TRPM2: NX_O94759

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O94759

TRPM2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003298.1

ENSEMBL proteins:

ENSP00000300482 ENSP00000393982 ENSP00000381023 ENSP00000381026 ENSP00000300481

Human Recombinant Protein Products:

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	Uscn Proteins for TRPM2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	--	--
GO:0005887	integral to plasma membrane	TAS	9806837
GO:0016021	integral to membrane	--	--

TRPM2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for TRPM2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TRPM2 for domains About GeneDecksing

3 InterPro domains/families:

IPR015797 NUDIX_hydrolase_dom-like

IPR005821 Ion_trans_dom

IPR000086 NUDIX_hydrolase_dom

Graphical View of Domain Structure for InterPro Entry O94759

ProtoNet protein and cluster: O94759

2 Blocks protein families:

IPB000086 NUDIX hydrolase

IPB002153 Transient receptor potential family signature

UniProtKB/Swiss-Prot: TRPM2_HUMAN, O94759

Similarity: Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily

Similarity: Contains 1 nudix hydrolase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TRPM2_HUMAN, O94759

Function: Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to

oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive

regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive

nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death

following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity

Catalytic activity: ADP-D-ribose + H(2)O = AMP + D-ribose 5-phosphate

Biophysicochemical properties: Kinetic parameters: KM=100 uM for ADP-ribose; Vmax=0.1 umol/min/mg enzyme;

Induction: NAD(+)

Enzyme Number (IUBMB): EC 3.6.1.13¹

miRNA Products:		OriGene 3'-UTR Clone: TRPM2 Browse MicroRNA Expression Plasmids
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		hsa-miR-3184 hsa-miR-423-5p
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPM2

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005216	ion channel activity	--	--
GO:0005262	calcium channel activity	IEA	--
GO:0005272	sodium channel activity	IEA	--
GO:0005384	manganese ion transmembrane transporter activity	IEA	--
GO:0016787	hydrolase activity	--	--

TRPM2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for TRPM2:

Synthetic lethal with Ras

Animal Models:
Mouse knock-out Trpm2^tm1Yamo for TRPM2
4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Trpm2):

homeostasis/metabolism

immune system

liver/biliary system

mortality/aging

TRPM2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Sodium channels and transporters: inward current

Sodium channels and transporters: inward current

1.00

CREB Pathway

Intracellular Calcium Signaling

0.50

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for TRPM2

Sodium channels and transporters- inward current

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TRPM2

Intracellular Calcium Signaling

TRPM2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TRPM2

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/7 Interacting proteins for TRPM2 (O94759³ ENSP00000300482⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TRPC6	Q9Y210³, ENSP00000340913⁴	I2D: score=1 STRING: ENSP00000340913
ITPR3	Q14573³, ENSP00000363435⁴	I2D: score=2 STRING: ENSP00000363435
CLU	ENSP00000315130⁴	STRING: ENSP00000315130
H2AFX	ENSP00000364310⁴	STRING: ENSP00000364310
TNIK	ENSP00000399511⁴	STRING: ENSP00000399511

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006816	calcium ion transport	TAS	9806837
GO:0006828	manganese ion transport	--	--
GO:0033194	response to hydroperoxide	IEA	--
GO:0070588	calcium ion transmembrane transport	--	--
GO:0071421	manganese ion transmembrane transport	--	--

TRPM2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TRPM2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TRPM2

3 HMDB Compounds for TRPM2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
NAD	3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)	53-84-9	--
Sodium	Sodium (see all 2)	7440-23-5	--

7 Novoseek chemical compound relationships for TRPM2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
adpribose	90.6	82	16585058 (5), 18572241 (5), 15347676 (4), 16604090 (4) (see all 25)
flufenamic acid	79.1	7	15275834 (3), 18204483 (1), 19124544 (1)
nad+	51.7	4	11804595 (1), 16565078 (1), 15275834 (1)
h2o2	46.9	24	18048770 (4), 16651700 (4), 11804595 (2), 16604090 (2) (see all 10)
calcium	45.5	27	12529379 (4), 18048770 (4), 11804595 (3), 16651700 (3) (see all 10)
oxygen	18.8	4	15708008 (1), 20194125 (1), 11804595 (1), 19124544 (1)
estrogen	0	1	8252481 (1)

Search CenterWatch for drugs/clinical trials and news about TRPM2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TRPM2 gene (2 alternative transcripts):

NM_003307.3 NM_001001188.3

Unigene Cluster for TRPM2:

Transient receptor potential cation channel, subfamily M, member 2

Hs.369759 [show with all ESTs]

Unigene Representative Sequence: AB166745

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000300482(uc002zet.1 uc021wjr.1 uc002zew.1 uc010gpt.1)

ENST00000431901 ENST00000397928(uc002zeu.1) ENST00000397932 ENST00000300481

ENST00000498430(uc002zex.1 uc002zey.1 uc011aff.1) ENST00000490982

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		hsa-miR-3184 hsa-miR-423-5p
		SwitchGear 3'UTR luciferase reporter plasmid: TRPM2 3' UTR sequence

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Additional cDNA sequence:

AB166745.1 AB166746.1 AJ878416.1 AK301101.1 AK301451.1 AY603182.1 BC112342.1 EU362987.1

NR_038257.1

7 DOTS entries:

DT.407683 DT.100746078 DT.121142606 DT.121142614 DT.121142616 DT.121142622 DT.121142609

24/91 AceView cDNA sequences (see all 91):

BI906484 BQ276462 BQ722994 BU543741 AI380559 AW292642 AI739196 BC041570

BE535510 BG774493 BU179127 BF064117 NM_003307 BM795023 AI971759 NM_001001188

CD616816 BQ680376 AJ417076 BP362165 BQ774297 BM792157 BU617731 BU617475

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for TRPM2 About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21a	·	21b	^	22a	·	22b	^	23a	·
SP1:																																											-
SP2:
SP3:			-
SP4:																																															-
SP5:

ExUns:	23b	^	24a	·	24b	^	25a	·	25b	^	26a	·	26b	^	27	^	28	^	29	^	30	^	31	^	32	^	33a	·	33b
SP1:			-
SP2:																	-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for TRPM2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRPM2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGGGGTTTG

About this image

TRPM2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TRPM2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRPM2

SOURCE GeneReport for Unigene cluster: Hs.369759

UniProtKB/Swiss-Prot: TRPM2_HUMAN, O94759

Tissue specificity: Highly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in bone

marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes

SABiosciences Expression via Pathway-Focused PCR Array including TRPM2:

Neuronal Ion Channels in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRPM2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPM2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TRPM2 gene from 4/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TRPM2¹	transient receptor potential cation channel, subfamily more	76.24(n) 74.82(a)		424835 XM_422646.3 XP_422646.2
lizard (Anolis carolinensis)	Reptilia	TRPM2⁶	--	73(a)	1 ↔ 1	3(33698134-33741420)
zebrafish (Danio rerio)	Actinopterygii	si:ch73-263b18.1⁶	si:ch73-263b18.1	50(a)	1 ↔ 1	9(54458322-54745644)
worm (Caenorhabditis elegans)	Secernentea	ced-11⁶	Protein ced-11	13(a)	possible ortholog	III(9119482-9125073)

ENSEMBL Gene Tree for TRPM2 (if available)
TreeFam Gene Tree for TRPM2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TRPM2 gene

TRPM5² TRPM8² TRPM7² TRPM1² TRPM6² TRPM4² TRPM3²

7 SIMAP similar genes for TRPM2 using alignment to 6 protein entries: TRPM2_HUMAN (see all proteins):

TRPM8 MLSN2 TRPM5 TRPM3 TRPM4 TRPM6

NUDT9

TRPM2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 21 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs146691229^1,2	C	other	45819276(+)	`CAGCTC/TGCCCT`	3	L	nc-transcript-variantsyn¹		1		NA	4544
rs181064143^1,2		--	45771503(+)	`AAGAAC/TCCCAG`	2	--	us2k¹		0	--	--	--	--
rs184138807^1,2		--	45771537(+)	`AGGTCA/GTTGCC`	2	--	us2k¹		0	--	--	--	--
rs116478750^1,2		--	45771592(+)	`GCACCC/TGTCCT`	2	--	us2k¹		1		WA	118
rs928854^1,2	C,H,	--	45771629(+)	`CCCCCC/GACAGC`	2	--	us2k¹		7		NA NS EA	444
rs28427878^1,2	C,F,	--	45771845(+)	`ACCGTG/AGACCC`	2	--	us2k¹		10		NS NA WA CSA	322
rs189403626^1,2		--	45771954(+)	`CCTTGC/TGGTGC`	2	--	us2k¹		0	--	--	--	--
rs28710032^1,2		--	45772016(+)	`TGCCCA/CTCTGC`	2	--	us2k¹		0	--	--	--	--
rs45578237^1,2	C,F,	--	45772040(+)	`TGGTTG/CTGAAG`	2	--	us2k¹		5		NS	186
rs45453794^1,2	C,F,	--	45772062(+)	`GCTGCG/AGGGAC`	2	--	us2k¹		6		NS WA	302

HapMap Linkage Disequilibrium report for TRPM2 (45770046 - 45862964 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 18 variations for TRPM2
6 CNVs: 73652 103109 103108 10603 73651 7327
12 Indels: 46181 40486 42312 46182 61981 26982 26984 40487 26986 26983 26985 73650
Human Gene Mutation Database (HGMD): TRPM2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TRPM2 for disorders           About GeneDecksing

OMIM gene information: 603749    OMIM disorders: --

8 diseases for TRPM2:    About MalaCards

type 2 diabetes mellitus bipolar affective disorder diabetes mellitus bipolar disorder

breast cancer prostate cancer prostatitis neuronitis

3 Novoseek disease relationships for TRPM2 gene About this table

Disease	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	1	8252481 (1)
breast cancer	2	8252481 (2)
tumors	8	8252481 (4)

Genetic Association Database (GAD): TRPM2
Human Genome Epidemiology (HuGE) Navigator: TRPM2 (39 documents)

Export disorders for TRPM2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TRPM2 gene, integrated from 9 sources (see all 96):
(articles sorted by number of sources associating them with TRPM2)

Utopia: connect your pdf to the dynamic
world of online information

ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. (PubMed id 11385575)^{1, 2, 3} Perraud A.-L....Scharenberg A.M. (2001)
Molecular cloning of a novel putative Ca2+ channel protein (TRPC7) highly expressed in brain. (PubMed id 9806837)^{1, 2, 3} Nagamine K....Shimizu N. (1998)
A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death. (PubMed id 12594222)^{1, 2, 9} Zhang W....Miller B.A. (2003)
Characterization of human and mouse TRPM2 genes: identification of a novel N-terminal truncated protein specifically expressed in human striatum. (PubMed id 15708008)^{1, 2, 9} Uemura T.... Shimizu N. (2005)
LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. (PubMed id 11804595)^{1, 2, 9} Hara Y.... Mori Y. (2002)
Association of the putative susceptibility gene, transient receptor potential protein melastatin type 2, with bipolar disorder. (PubMed id 16252251)^{1, 4} Xu C....Warsh J.J. (2006)
International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. (PubMed id 16382100)^{1, 3} Clapham D.E....Schultz G. (2005)
Activation of the cation channel long transient receptor potential channel 2 (LTRPC2) by hydrogen peroxide. A splice variant reveals a mode of activation independent of ADP-ribose. (PubMed id 11960981)^{1, 2} Wehage E.... Lueckhoff A. (2002)
Immunocyte Ca2+ influx system mediated by LTRPC2. (PubMed id 11509734)^{1, 2} Sano Y....Furuichi K. (2001)
The DNA sequence of human chromosome 21. (PubMed id 10830953)^{1, 2} Hattori M....Yaspo M.L. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7226	HGNC: 12339	AceView: TRPM2	Ensembl:ENSG00000142185	euGenes: HUgn7226
ECgene: TRPM2	H-InvDB: TRPM2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TRPM2	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/trpm2/

Intellectual Property for TRPM2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TRPM2 gene:
Search GeneIP for patents involving TRPM2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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