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Aliases for TRPM2 Gene

Aliases for TRPM2 Gene

  • Transient Receptor Potential Cation Channel Subfamily M Member 2 2 3
  • Transient Receptor Potential Cation Channel, Subfamily M, Member 2 2 3 5
  • Estrogen-Responsive Element-Associated Gene 1 Protein 3 4
  • Long Transient Receptor Potential Channel 2 3 4
  • Transient Receptor Potential Channel 7 3 4
  • LTrpC-2 3 4
  • LTRPC2 3 4
  • TrpC7 3 4
  • EREG1 3 4
  • KNP3 3 4
  • EC 3.6.1.13 4
  • NUDT9L1 3
  • NUDT9H 3

External Ids for TRPM2 Gene

Previous HGNC Symbols for TRPM2 Gene

  • TRPC7

Previous GeneCards Identifiers for TRPM2 Gene

  • GC21P042282
  • GC21P044629
  • GC21P044597
  • GC21P045770
  • GC21P031143

Summaries for TRPM2 Gene

Entrez Gene Summary for TRPM2 Gene

  • The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2016]

GeneCards Summary for TRPM2 Gene

TRPM2 (Transient Receptor Potential Cation Channel Subfamily M Member 2) is a Protein Coding gene. Among its related pathways are Ion channel transport and CREB Pathway. GO annotations related to this gene include hydrolase activity and calcium channel activity. An important paralog of this gene is TRPM1.

UniProtKB/Swiss-Prot for TRPM2 Gene

  • Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity.

Gene Wiki entry for TRPM2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRPM2 Gene

Genomics for TRPM2 Gene

Regulatory Elements for TRPM2 Gene

Enhancers for TRPM2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRPM2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRPM2 Gene

Chromosome:
21
Start:
44,350,126 bp from pter
End:
44,443,081 bp from pter
Size:
92,956 bases
Orientation:
Plus strand

Genomic View for TRPM2 Gene

Genes around TRPM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRPM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRPM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRPM2 Gene

Proteins for TRPM2 Gene

  • Protein details for TRPM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94759-TRPM2_HUMAN
    Recommended name:
    Transient receptor potential cation channel subfamily M member 2
    Protein Accession:
    O94759
    Secondary Accessions:
    • D3DSL6
    • Q5KTC2
    • Q6J3P5
    • Q96KN6
    • Q96Q93

    Protein attributes for TRPM2 Gene

    Size:
    1503 amino acids
    Molecular mass:
    171198 Da
    Quaternary structure:
    • Isoform 1 can interact with isoform 3. This interaction decreases calcium influx through isoform 1 and suppresses susceptibility to oxidative stress-induced cell death.
    SequenceCaution:
    • Sequence=BAB64300.1; Type=Frameshift; Positions=1227, 1237; Evidence={ECO:0000305};

    Alternative splice isoforms for TRPM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRPM2 Gene

Proteomics data for TRPM2 Gene at MOPED

Post-translational modifications for TRPM2 Gene

  • Ubiquitination at Lys 307
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TRPM2 Gene

Domains & Families for TRPM2 Gene

Graphical View of Domain Structure for InterPro Entry

O94759

UniProtKB/Swiss-Prot:

TRPM2_HUMAN :
  • Contains 1 nudix hydrolase domain.
  • Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily.
Domain:
  • Contains 1 nudix hydrolase domain.
Family:
  • Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily.
genes like me logo Genes that share domains with TRPM2: view

Function for TRPM2 Gene

Molecular function for TRPM2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=100 uM for ADP-ribose; Vmax=0.1 umol/min/mg enzyme;
UniProtKB/Swiss-Prot CatalyticActivity:
ADP-D-ribose + H(2)O = AMP + D-ribose 5-phosphate.
UniProtKB/Swiss-Prot Function:
Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity.
UniProtKB/Swiss-Prot Induction:
NAD(+).

Enzyme Numbers (IUBMB) for TRPM2 Gene

genes like me logo Genes that share phenotypes with TRPM2: view

Animal Models for TRPM2 Gene

MGI Knock Outs for TRPM2:

Animal Model Products

  • Taconic Biosciences Mouse Models for TRPM2

CRISPR Products

miRNA for TRPM2 Gene

miRTarBase miRNAs that target TRPM2

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRPM2 Gene

Localization for TRPM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRPM2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRPM2 Gene COMPARTMENTS Subcellular localization image for TRPM2 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for TRPM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with TRPM2: view

Pathways & Interactions for TRPM2 Gene

genes like me logo Genes that share pathways with TRPM2: view

Pathways by source for TRPM2 Gene

1 Qiagen pathway for TRPM2 Gene

Gene Ontology (GO) - Biological Process for TRPM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006816 calcium ion transport TAS 9806837
GO:0006979 response to oxidative stress IEA --
GO:0034220 ion transmembrane transport TAS --
GO:0035725 sodium ion transmembrane transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with TRPM2: view

No data available for SIGNOR curated interactions for TRPM2 Gene

Drugs & Compounds for TRPM2 Gene

(20) Drugs for TRPM2 Gene - From: DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Clotrimazole Approved Pharma Inhibition, Pore Blocker, inhibitor Cytochrome P450 inhibitor; antifungal 30
Econazole Approved Pharma Antagonist, Pore Blocker, inhibitor 7
Miconazole Approved, Investigational Pharma Antagonist, Pore Blocker, inhibitor 3525
Adenosine monophosphate Approved Nutra 0
Flufenamic acid Experimental Pharma Channel blocker Activates TRPC6; NSAID 0

(9) Additional Compounds for TRPM2 Gene - From: HMDB, Novoseek, and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
H<sup>+</sup> (extracellular)
Activator
Adenosine diphosphate ribose
  • (Rib5)ppA
  • 5-(Adenosine 5'-pyrophosphoryl)-D-ribose
  • A5'pp5Rib
  • Adenosine 5'-diphosphoribose
  • Adenosine diphosphate ribose
20762-30-5
D-Ribose 5-phosphate
  • D-Ribose 5-phosphate
  • D-Ribose-5-P
  • D-Ribose-5-phosphate
  • D-Ribose-5-phosphorate
  • D-Ribose-5-phosphoric acid
3615-55-2
sodium
  • Sodium
  • Sodium ion
7440-23-5
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with TRPM2: view

Transcripts for TRPM2 Gene

Unigene Clusters for TRPM2 Gene

Transient receptor potential cation channel, subfamily M, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRPM2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a ·
SP1: -
SP2:
SP3: -
SP4: -
SP5:

ExUns: 23b ^ 24a · 24b ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b
SP1: -
SP2: -
SP3:
SP4:
SP5:

Relevant External Links for TRPM2 Gene

GeneLoc Exon Structure for
TRPM2
ECgene alternative splicing isoforms for
TRPM2

Expression for TRPM2 Gene

mRNA expression in normal human tissues for TRPM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRPM2 Gene

This gene is overexpressed in Whole Blood (x6.9).

Protein differential expression in normal tissues from HIPED for TRPM2 Gene

This gene is overexpressed in Testis (56.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRPM2 Gene



SOURCE GeneReport for Unigene cluster for TRPM2 Gene Hs.369759

mRNA Expression by UniProt/SwissProt for TRPM2 Gene

O94759-TRPM2_HUMAN
Tissue specificity: Highly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in bone marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes.
genes like me logo Genes that share expression patterns with TRPM2: view

Protein tissue co-expression partners for TRPM2 Gene

Primer Products

Orthologs for TRPM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRPM2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRPM2 35
  • 83.43 (n)
  • 79.65 (a)
TRPM2 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRPM2 35
  • 85.36 (n)
  • 83.31 (a)
-- 36
  • 78 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Trpm2 35
  • 83.5 (n)
  • 85.66 (a)
Trpm2 16
Trpm2 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRPM2 35
  • 98.8 (n)
  • 98.74 (a)
TRPM2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trpm2 35
  • 83.79 (n)
  • 85.14 (a)
oppossum
(Monodelphis domestica)
Mammalia TRPM2 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
chicken
(Gallus gallus)
Aves TRPM2 35
  • 76.27 (n)
  • 74.8 (a)
TRPM2 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRPM2 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trpm2 35
  • 64.05 (n)
  • 68.34 (a)
zebrafish
(Danio rerio)
Actinopterygii trpm2 36
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta trpm 36
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gon-2 36
  • 18 (a)
ManyToMany
gtl-1 36
  • 20 (a)
ManyToMany
gtl-2 36
  • 25 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for TRPM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRPM2 Gene

ENSEMBL:
Gene Tree for TRPM2 (if available)
TreeFam:
Gene Tree for TRPM2 (if available)

Paralogs for TRPM2 Gene

Paralogs for TRPM2 Gene

(7) SIMAP similar genes for TRPM2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TRPM2: view

Variants for TRPM2 Gene

Sequence variations from dbSNP and Humsavar for TRPM2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1556314 - 44,391,460(+) GAGGA(G/T)CCCGA nc-transcript-variant, reference, missense
rs45625933 - 44,353,856(+) GGCAA(A/C)AATGA nc-transcript-variant, reference, missense
rs45544142 - 44,366,826(+) TGGAC(A/G)TCCCC nc-transcript-variant, reference, missense
rs45485992 - 44,379,135(+) TGAGC(A/G)TGTTC nc-transcript-variant, reference, missense
rs9974927 - 44,401,699(+) CAGGA(G/T)GTGGG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TRPM2 Gene

Variant ID Type Subtype PubMed ID
esv33817 CNV Loss 17666407
nsv913898 CNV Loss 21882294
nsv913906 CNV Loss 21882294
esv2723638 CNV Deletion 23290073
dgv4769n71 CNV Loss 21882294
dgv4770n71 CNV Loss 21882294
dgv4772n71 CNV Loss 21882294
dgv4773n71 CNV Loss 21882294
nsv509800 CNV Insertion 20534489
nsv913943 CNV Loss 21882294
esv27433 CNV Gain+Loss 19812545
esv2673819 CNV Deletion 23128226
esv2723644 CNV Deletion 23290073
esv2723645 CNV Deletion 23290073
nsv3539 CNV Insertion 18451855
nsv817934 CNV Loss 17921354
esv2723646 CNV Deletion 23290073
esv23823 CNV Loss 19812545
esv2723647 CNV Deletion 23290073
esv1217346 CNV Deletion 17803354
esv2678126 CNV Deletion 23128226
esv1540187 CNV Deletion 17803354
esv2723648 CNV Deletion 23290073
esv2723649 CNV Deletion 23290073
esv27471 CNV Gain 19812545
esv2636773 CNV Deletion 19546169
esv2723651 CNV Deletion 23290073
esv2310692 CNV Deletion 18987734
esv2723652 CNV Deletion 23290073
esv1238729 CNV Deletion 17803354
esv2723653 CNV Deletion 23290073
esv2723654 CNV Deletion 23290073
esv1196219 CNV Deletion 17803354
nsv519245 CNV Loss 19592680
nsv913945 CNV Loss 21882294
nsv913946 CNV Gain 21882294
esv2723655 CNV Deletion 23290073
esv2723656 CNV Deletion 23290073
esv2723657 CNV Deletion 23290073
esv2549295 CNV Deletion 19546169
esv2299983 CNV Deletion 18987734
esv3375 CNV Deletion 18987735
esv2723658 CNV Deletion 23290073
esv6021 CNV Loss 19470904
esv1585847 CNV Deletion 17803354
nsv913947 CNV Loss 21882294
nsv913948 CNV Loss 21882294

Variation tolerance for TRPM2 Gene

Residual Variation Intolerance Score: 97.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.29; 76.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRPM2 Gene

Human Gene Mutation Database (HGMD)
TRPM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRPM2 Gene

Disorders for TRPM2 Gene

Relevant External Links for TRPM2

Genetic Association Database (GAD)
TRPM2
Human Genome Epidemiology (HuGE) Navigator
TRPM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRPM2

No disorders were found for TRPM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRPM2 Gene

Publications for TRPM2 Gene

  1. ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. (PMID: 11385575) Perraud A.-L. … Scharenberg A.M. (Nature 2001) 2 3 4 67
  2. Transient receptor potential melastatin 2 is required for lipopolysaccharide-induced cytokine production in human monocytes. (PMID: 20107186) Wehrhahn J. … Hauschildt S. (J. Immunol. 2010) 3 23
  3. The calcium-permeable non-selective cation channel TRPM2 is modulated by cellular acidification. (PMID: 20194125) Starkus J.G. … Penner R. (J. Physiol. (Lond.) 2010) 3 23
  4. H2O2-induced Ca2+ influx and its inhibition by N-(p-amylcinnamoyl) anthranilic acid in the beta-cells: involvement of TRPM2 channels. (PMID: 19382906) Bari M.R. … Islam M.S. (J. Cell. Mol. Med. 2009) 3 23
  5. In with the TRP channels: intracellular functions for TRPM1 and TRPM2. (PMID: 19887679) Patel S. … Docampo R. (Sci Signal 2009) 3 23

Products for TRPM2 Gene

Sources for TRPM2 Gene

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