Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TRPC7 Gene

protein-coding   GIFtS: 60
GCID: GC05M135549

Transient Receptor Potential Cation Channel, Subfamily C,...

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

TryGeneCards Plus

Aliases
Transient Receptor Potential Cation Channel, Subfamily C, Member 71 2     Likley Ortholog Of Mouse Transient Receptor Potential Cation Channel,
Subfamily C, Member 72
Transient Receptor Protein 72 3     Putative Capacitative Calcium Channel2
TRP-72 3     Short Transient Receptor Potential Channel 72
TRP72 3     TrpC73
hTRP72 3     KNP35
Transient Receptor Potential-Related Channel 7, A Novel Putative Ca2+
Channel Protein11
     TRPM25

External Ids:    HGNC: 207541   Entrez Gene: 571132   Ensembl: ENSG000000690187   OMIM: 6037495   UniProtKB: Q9HCX43   

Export aliases for TRPC7 gene to outside databases

Previous GC identifers: GC05M135424 GC05M136212 GC05M135579 GC05M135625 GC05M135577 GC05M130737


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for TRPC7 Gene:
TRPC7 (transient receptor potential cation channel, subfamily C, member 7) is a protein-coding gene. GO annotations related to this gene include calcium channel activity. An important paralog of this gene is TRPC4.

UniProtKB/Swiss-Prot: TRPC7_HUMAN, Q9HCX4
Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated
by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled
receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium
store depletion

Gene Wiki entry for TRPC7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRPC7 gene promoter:
         LHX3b/Lhx3b   AML1a   NRSF form 1   STAT1beta   MIF-1   Nkx2-5   NRSF form 2   STAT1alpha   RORalpha1   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRPC7 promoter sequence

   Search Chromatin IP Primers for TRPC7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRPC7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q31.2
Nature(405: 311-319) cytogenetic band:   21q22.3
TRPC7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRPC7 gene location
GeneLoc information about chromosome 5         GeneLoc Exon Structure

(about GC identifiers)
GC05M135549:   GeneLoc Nature:405,311-319
Start:
135,548,999 bp from pter       31,282,531 bp from centromere
End:
135,732,730 bp from pter 31,372,356 bp from centromere
Size:
183,732 bases 89,826 bases
Orientation:
minus strand plus strand

Whole chromosome sequencing:
cDNA sequence: AB001535
genomic clones: KUD99F9 to KB68A7


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TRPC7_HUMAN, Q9HCX4 (See protein sequence)
Recommended Name: Short transient receptor potential channel 7  
Size: 862 amino acids; 99562 Da
Subunit: Interacts with MX1 and RNF24. Interacts (via ANK-repeat domains) with PRKG1
Secondary accessions: A1A4Z4 F5H5U9 Q70T26 Q8IWP7
Alternative splicing: 3 isoforms:  Q9HCX4-1   Q9HCX4-2   Q9HCX4-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRPC7: NX_Q9HCX4

Explore proteomics data for TRPC7 at MOPED

Post-translational modifications: 

  • Phosphorylation by PRKG1 at Thr-15 negatively regulates TRPC7 activity1
  • Glycosylation2 at Asn514
  • Modification sites at PhosphoSitePlus

  • See TRPC7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001161048.1  NP_001161049.1  NP_065122.1  

    ENSEMBL proteins: 
     ENSP00000426070   ENSP00000421571   ENSP00000330322   ENSP00000426870   ENSP00000367720  
     ENSP00000424854   ENSP00000347312   ENSP00000441628  
    Reactome Protein details: Q9HCX4

    TRPC7 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TRPC7
    GenScript Custom Purified and Recombinant Proteins Services for TRPC7
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRPC7

     
    Search eBioscience for Proteins for TRPC7 

    TRPC7 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TRPC7
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TRPC7
    OriGene Custom Antibody Services for TRPC7
    Novus Biologicals TRPC7 Antibodies
    Abcam antibodies for TRPC7
    Cloud-Clone Corp. Antibodies for TRPC7
    ThermoFisher Antibodies for TRPC7
    LSBio Antibodies in human, mouse, rat for TRPC7

    TRPC7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TRPC7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRPC7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TRPC7
    Cloud-Clone Corp. CLIAs for TRPC7
    Search eBioscience for ELISAs for TRPC7 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    TRP: Voltage-gated ion channels / Transient receptor potential cation channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: TRPC7
    Transient Receptor Potential channels

    Selected InterPro protein domains (see all 7):
     IPR002153 TRPC_channel
     IPR005821 Ion_trans_dom
     IPR004729 TRP_channel
     IPR002110 Ankyrin_rpt
     IPR005463 TRPC7_channel

    Graphical View of Domain Structure for InterPro Entry Q9HCX4

    ProtoNet protein and cluster: Q9HCX4

    4 Blocks protein domains:
    IPB002110 Ankyrin repeat signature
    IPB002153 Transient receptor potential family signature
    IPB005463 Transient receptor potential channel 7 signature
    IPB013555 Transient receptor ion channel II


    UniProtKB/Swiss-Prot: TRPC7_HUMAN, Q9HCX4
    Similarity: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC7 sub-subfamily
    Similarity: Contains 4 ANK repeats


    Find genes that share domains with TRPC7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRPC7_HUMAN, Q9HCX4
    Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated
    by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled
    receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium
    store depletion

         Genatlas biochemistry entry for TRPC7:
    transient receptor potential non voltage-channel 7,Drosophila store-operated channel (Soc) homolog,expressed in
    brain activated by calcium store depletion,component of the capacitative calcium entry,channels (homo or
    heterotetramer)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005262calcium channel activity IEA--
    GO:0005488binding ----
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with TRPC7           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TRPC7:
     Decreased G3BP1 protein expres 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Trpc7):
     vision/eye 

    Find genes that share phenotypes with TRPC7           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Trpc7tm1.1Kofu for TRPC7

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRPC7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRPC7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRPC7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRPC7

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRPC7:
    hsa-mir-26b-5p (MIRT029163)

    Block miRNA regulation of human, mouse, rat TRPC7 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate TRPC7:
    hsa-miR-3673 hsa-miR-224 hsa-miR-138 hsa-miR-3176 hsa-miR-3922-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRPC7
    Predesigned siRNA for gene silencing in human, mouse, rat TRPC7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRPC7

    Clone
    Products:
         
    OriGene clones in human, mouse for TRPC7 (see all 15)
    OriGene ORF clones in mouse, rat for TRPC7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TRPC7 (NM_020389)
    Sino Biological Human cDNA Clone for TRPC7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRPC7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPC7

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TRPC7
    Browse ESI BIO Cell Lines and PureStem Progenitors for TRPC7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TRPC7_HUMAN, Q9HCX4: Cell membrane; Multi-pass membrane protein. Nucleus envelope
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytoskeleton1
    extracellular1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IEA--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0048471perinuclear region of cytoplasm IEA--

    Find genes that share ontologies with TRPC7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TRPC7 About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Platelet homeostasis
    Platelet homeostasis
    Platelet calcium homeostasis0.00
    Elevation of cytosolic Ca2+ levels0.00
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    5Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58


    Find genes that share SuperPaths with TRPC7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TRPC7
        Intracellular Calcium Signaling


    4 Reactome Pathways for TRPC7
        TRP channels
    Effects of PIP2 hydrolysis
    Role of second messengers in netrin-1 signaling
    Elevation of cytosolic Ca2+ levels


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRPC7
    Interactions:

        GeneGlobe Interaction Network for TRPC7

    4 Interacting proteins for TRPC7 (Q9HCX43) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MX1P205913I2D: score=3 
    ITPR3Q145733I2D: score=1 
    TRPC3Q135073I2D: score=1 
    TRPC6Q9Y2103I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0006816calcium ion transport ----
    GO:0006828manganese ion transport IEA--
    GO:0007411axon guidance TAS--
    GO:0007596blood coagulation TAS--

    Find genes that share ontologies with TRPC7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRPC7

    Selected HMDB Compounds for TRPC7 (see all 844)    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----

    4 IUPHAR Ligands for TRPC7 (TRPC7)    About this table
    LigandTypeActionAffinityPubmed IDs
    SKF96365
    Channel blockerNone--
    amiloride
    Channel blockerNone--
    La3+
    Channel blockerNone--
    2-APB
    Channel blockerNone--

    3 Novoseek inferred chemical compound relationships for TRPC7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thapsigargin 47.8 2 10488066 (1)
    calcium 46.6 15 10541222 (1), 10550622 (1), 12356946 (1), 11126000 (1) (see all 11)
    inositol 1,4,5 trisphosphate 32.6 1 15104179 (1)



    Find genes that share compounds with TRPC7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TRPC7 gene (3 alternative transcripts): 
    NM_001167576.1  NM_001167577.1  NM_020389.2  

    Unigene Cluster for TRPC7:

    Transient receptor potential cation channel, subfamily C, member 7
    Hs.591263  [show with all ESTs]
    Unigene Representative Sequence: NM_020389
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000513104(uc010jef.2 uc010jeg.2 uc003lbn.2) ENST00000509288
    ENST00000503275 ENST00000352189 ENST00000514963 ENST00000378459 ENST00000502753
    ENST00000514282 ENST00000355180(uc010jeh.2) ENST00000426057(uc010jej.2 uc010jei.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TRPC7 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate TRPC7:
    hsa-miR-3673 hsa-miR-224 hsa-miR-138 hsa-miR-3176 hsa-miR-3922-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TRPC7
    Predesigned siRNA for gene silencing in human, mouse, rat TRPC7
    Clone
    Products:
         
    OriGene clones in human, mouse for TRPC7 (see all 15)
    OriGene ORF clones in mouse, rat for TRPC7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TRPC7 (NM_020389)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRPC7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPC7
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TRPC7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRPC7
      QuantiTect SYBR Green Assays in human, mouse, rat TRPC7
      QuantiFast Probe-based Assays in human, mouse, rat TRPC7

    Additional mRNA sequence: 

    AJ272034.1 AJ421783.1 AJ549088.1 AJ549089.1 AJ549090.1 AY167926.1 AY167927.1 BC128185.1 
    BC128186.1 

    4 DOTS entries:

    DT.101981146  DT.92051190  DT.100008625  DT.100008626 

    19 AceView cDNA sequences:

    NM_020389 AJ272034 AJ549089 BX279646 AY167926 AY167927 AJ549090 AJ421783 
    BI826927 AJ549088 BG217935 BI765642 CD630109 CD630119 CD630114 CD630122 
    CD630118 CD630115 CD630111 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TRPC7 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b
    SP1:                                            -                                 
    SP2:              -                             -                                 
    SP3:        -                                   -                                 
    SP4:              -                             -                                 
    SP5:        -     -                             -                                 


    ECgene alternative splicing isoforms for TRPC7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TRPC7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TRPC7 Expression
    About this image


    TRPC7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neurons
             Mature Horizontal Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             Mature Horizontal Cells Inner Nuclear Layer
    TRPC7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRPC7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591263
        Custom PCR Arrays for TRPC7
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TRPC7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRPC7
    QuantiTect SYBR Green Assays in human, mouse, rat TRPC7
    QuantiFast Probe-based Assays in human, mouse, rat TRPC7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for TRPC7 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trpc71 , 5 transient receptor potential cation channel, subfamily more1, 5 90.53(n)1
    98.14(a)1
      13 (30.27 cM)5
    269461  NM_012035.21  NP_036165.11 
     567731135 
    chicken
    (Gallus gallus)
    Aves TRPC71 transient receptor potential cation channel, subfamily more 81.18(n)
    94.6(a)
      427641  XM_004944982.1  XP_004945039.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRPC76
    transient receptor potential cation channel, subfa...
    93(a)
    1 ↔ 1
    GL343223.1(1745057-1913136)
    zebrafish
    (Danio rerio)
    Actinopterygii trpc7a1 transient receptor potential cation channel, subfamily more 74.92(n)
    84.98(a)
      567566  XM_690863.3  XP_695955.3 


    ENSEMBL Gene Tree for TRPC7 (if available)
    TreeFam Gene Tree for TRPC7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TRPC7 gene
    TRPC42  TRPC12  TRPC62  TRPC52  TRPC32  
    5 SIMAP similar genes for TRPC7 using alignment to 9 protein entries:     TRPC7_HUMAN (see all proteins):
    TRP7    TRPC3    TRPC6    TRPC4    TRPC5

    Find genes that share paralogs with TRPC7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TRPC7 (see all 2850)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs768872391,2
    --135549032(+) AGTGGG/TCTGGG 3 -- ut310--------
    rs1152466771,2
    C,F--135549043(+) GACCCC/TTCCCC 3 -- ut311Minor allele frequency- T:0.03WA 118
    rs2014000421,2
    C,F--135549206(+) CAGGTC/TTGCCA 6 N D mis11Minor allele frequency- T:0.00EU 579
    rs1490405871,2
    C--135549339(+) AAGCTC/TGGGGC 3 -- int10--------
    rs1841484661,2
    --135549454(+) CAGAAC/TCACCC 3 -- int10--------
    rs1871177961,2
    --135549581(+) GTCTAC/GCACTT 3 -- int10--------
    rs747551451,2
    C,F--135549679(+) CATTGC/ATTTTG 3 -- int11Minor allele frequency- A:0.06WA 118
    rs1165002041,2
    F--135549711(+) TCATTG/ATTATT 3 -- int11Minor allele frequency- A:0.02WA 118
    rs1911719361,2
    C--135549752(+) AGAGAA/GTGGCT 3 -- int10--------
    rs1825506791,2
    --135549759(+) GGCTCA/GGCACA 3 -- int10--------

    HapMap Linkage Disequilibrium report for TRPC7 (135548999 - 135732730 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TRPC7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667747CNV Deletion23128226
    esv2661991CNV Deletion23128226
    esv271457CNV Insertion20981092
    nsv508381CNV Loss20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRPC7
    DNA2.0 Custom Variant and Variant Library Synthesis for TRPC7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603749    OMIM disorders: --


    Find genes that share disorders with TRPC7           About GenesLikeMe

    Genetic Association Database (GAD): TRPC7
    Human Genome Epidemiology (HuGE) Navigator: TRPC7 (6 documents)

    Export disorders for TRPC7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TRPC7 gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with TRPC7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx. (PubMed id 11805119)1, 3, 9 Riccio A.... Pangalos M.N. (J. Biol. Chem. 2002)
    2. Functional regulation of transient receptor potential canonical 7 by cGMP-dependent protein kinase Ialpha. (PubMed id 21402151)1, 2 Yuasa K.... Tsuji A. (Cell. Signal. 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis. (PubMed id 19240791)1, 4 Graubert T.A....Walter M.J. (PLoS ONE 2009)
    5. MxA, a member of the dynamin superfamily, interacts with the ankyrin- like repeat domain of TRPC. (PubMed id 15757897)1, 2 Lussier M.P.... Boulay G. (J. Biol. Chem. 2005)
    6. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. (PubMed id 16382100)1, 3 Clapham D.E....Schultz G. (Pharmacol. Rev. 2005)
    7. TRPC7. (PubMed id 17217055)1, 9 Numaga T....Mori Y. (Handb Exp Pharmacol 2007)
    8. Endogenous TRPC1, TRPC3, and TRPC7 proteins combine to form native store-operated channels in HEK-293 cells. (PubMed id 15972814)1, 9 Zagranichnaya T.K....Villereal M.L. (J. Biol. Chem. 2005)
    9. Canonical transient receptor potential TRPC7 can function as both a receptor- and store-operated channel in HEK-293 cells. (PubMed id 15342342)1, 9 LiA"vremont J.P....Putney J.W. (Am. J. Physiol., Cell Physiol. 2004)
    10. A pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7. (PubMed id 19812035)1, 9 Miyagi K....Mori Y. (J. Biol. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 57113 HGNC: 20754 AceView: TRPC7 Ensembl:ENSG00000069018 euGenes: HUgn57113
    ECgene: TRPC7 H-InvDB: TRPC7

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TRPC7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TRPC7 gene:
    Search GeneIP for patents involving TRPC7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of TRPC7
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TRPC7   OriGene RNAi products in human, mouse, rat for TRPC7  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TRPC7  
     OriGene qSTAR qPCR primer pairs in human, mouse for TRPC7   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TRPC7   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TRPC7   OriGene Custom Protein Services for TRPC7  

     
     
     Block miRNA regulation of human, mouse, rat TRPC7 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TRPC7
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRPC7 Predesigned siRNA for gene silencing in human, mouse, rat TRPC7
     QuantiFast Probe-based Assays in human, mouse, rat TRPC7 QuantiTect SYBR Green Assays in human, mouse, rat TRPC7
     Custom PCR Arrays for TRPC7 Search Chromatin IP Primers for TRPC7
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRPC7  GeneGlobe Interaction Network for TRPC7
     Regulatory tfbs in TRPC7 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TRPC7 GenScript cDNA clones with any tag delivered in your preferred vector for TRPC7
     GenScript Custom Assay Services for TRPC7 GenScript Custom overexpressing Cell Line Services for TRPC7
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TRPC7
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for TRPC7
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TRPC7 antibodies
     Antibodies for TRPC7
     See all of Abcam's Antibodies, Kits and Proteins for TRPC7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TRPC7
     Antibodies for TRPC7
     ELISAs for TRPC7
     CLIAs for TRPC7



     Browse ESI BIO Cell Lines and PureStem Progenitors for TRPC7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC7
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TRPC7
     SwitchGear Promoter luciferase reporter plasmids for TRPC7
     ThermoFisher Antibodies for TRPC7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPC7
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRPC7
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRPC7
     LSBio Antibodies in human, mouse, rat for TRPC7
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for TRPC7
      Search eBioscience for proteins for TRPC7
      Search eBioscience for elisas for TRPC7
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TRPC7 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4