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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRPC7 Gene

protein-coding   GIFtS: 59
GCID: GC05M135549

Transient Receptor Potential Cation Channel, Subfamily C,...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

Aliases
Transient Receptor Potential Cation Channel, Subfamily C, Member 71 2     Likley Ortholog Of Mouse Transient Receptor Potential Cation Channel,
Subfamily C, Member 72
Transient Receptor Protein 72 3     Putative Capacitative Calcium Channel2
TRP-72 3     Short Transient Receptor Potential Channel 72
TRP72 3     TrpC73
hTRP72 3     KNP35
Transient Receptor Potential-Related Channel 7, A Novel Putative Ca2+
Channel Protein11
     TRPM25

External Ids:    HGNC: 207541   Entrez Gene: 571132   Ensembl: ENSG000000690187   OMIM: 6037495   UniProtKB: Q9HCX43   

Export aliases for TRPC7 gene to outside databases

Previous GC identifers: GC05M135424 GC05M136212 GC05M135579 GC05M135625 GC05M135577 GC05M130737


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TRPC7 Gene: 
TRPC7 (transient receptor potential cation channel, subfamily C, member 7) is a protein-coding gene. Diseases associated with TRPC7 include myelodysplastic syndromes, and gingivitis, and among its related super-pathways are Signaling by GPCR and Gastrin-CREB signalling pathway via PKC and MAPK. GO annotations related to this gene include protein binding and calcium channel activity. An important paralog of this gene is TRPC4.

UniProtKB/Swiss-Prot: TRPC7_HUMAN, Q9HCX4
Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated
by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled
receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium
store depletion

Gene Wiki entry for TRPC7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_034772.6  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRPC7 gene promoter:
         LHX3b/Lhx3b   AML1a   NRSF form 1   STAT1beta   MIF-1   Nkx2-5   NRSF form 2   STAT1alpha   RORalpha1   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRPC7 promoter sequence

   Search SABiosciences Chromatin IP Primers for TRPC7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRPC7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q31.2
Nature(405: 311-319) cytogenetic band:   21q22.3
TRPC7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRPC7 gene location
GeneLoc information about chromosome 5         GeneLoc Exon Structure

(about GC identifiers)
GC05M135549:   GeneLoc Nature:405,311-319
Start:
135,548,999 bp from pter       31,282,531 bp from centromere
End:
135,732,730 bp from pter 31,372,356 bp from centromere
Size:
183,732 bases 89,826 bases
Orientation:
minus strand plus strand

Whole chromosome sequencing:
cDNA sequence: AB001535
genomic clones: KUD99F9 to KB68A7


(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRPC7_HUMAN, Q9HCX4 (See protein sequence)
Recommended Name: Short transient receptor potential channel 7  
Size: 862 amino acids; 99562 Da
Subunit: Interacts with MX1 and RNF24. Interacts (via ANK-repeat domains) with PRKG1
Subcellular location: Cell membrane; Multi-pass membrane protein. Nucleus envelope
Secondary accessions: A1A4Z4 F5H5U9 Q70T26 Q8IWP7
Alternative splicing: 3 isoforms:  Q9HCX4-1   Q9HCX4-2   Q9HCX4-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRPC7: NX_Q9HCX4

Explore proteomics data for TRPC7 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation by PRKG1 at Thr-15 negatively regulates TRPC7 activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HCX4

  • TRPC7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRPC7 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001161048.1  NP_001161049.1  NP_065122.1  

    ENSEMBL proteins: 
     ENSP00000426070   ENSP00000421571   ENSP00000330322   ENSP00000426870   ENSP00000367720  
     ENSP00000424854   ENSP00000347312   ENSP00000441628  
    Reactome Protein details: Q9HCX4
    Human Recombinant Protein Products for TRPC7: 
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    Cloud-Clone Corp. Proteins for TRPC7 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IEA--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    TRPC7 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TRP: Voltage-gated ion channels / Transient receptor potential cation channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: TRPC7 
    Transient Receptor Potential channels

    5/7 InterPro protein domains (see all 7):
     IPR005463 TRPC7_channel
     IPR002153 TRPC_channel
     IPR020683 Ankyrin_rpt-contain_dom
     IPR005821 Ion_trans_dom
     IPR004729 TRP_channel

    Graphical View of Domain Structure for InterPro Entry Q9HCX4

    ProtoNet protein and cluster: Q9HCX4

    4 Blocks protein domains:
    IPB002110 Ankyrin repeat signature
    IPB002153 Transient receptor potential family signature
    IPB005463 Transient receptor potential channel 7 signature
    IPB013555 Transient receptor ion channel II


    UniProtKB/Swiss-Prot: TRPC7_HUMAN, Q9HCX4
    Similarity: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC7 sub-subfamily
    Similarity: Contains 4 ANK repeats


    TRPC7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRPC7_HUMAN, Q9HCX4
    Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated
    by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled
    receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium
    store depletion

         Genatlas biochemistry entry for TRPC7:
    transient receptor potential non voltage-channel 7,Drosophila store-operated channel (Soc) homolog,expressed in
    brain activated by calcium store depletion,component of the capacitative calcium entry,channels (homo or
    heterotetramer)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005262calcium channel activity IEA--
    GO:0005488binding ----
    GO:0005515protein binding IPI--
         
    TRPC7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TRPC7:
     Decreased G3BP1 protein expres 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Trpc7):
     vision/eye 

    TRPC7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Trpc7tm1.1Kofu for TRPC7

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRPC7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRPC7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRPC7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRPC7 

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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TRPC7 About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    2G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    3Axon guidance
    Axon guidance0.69
    Developmental Biology0.69
    4Platelet calcium homeostasis
    Platelet calcium homeostasis0.53
    Elevation of cytosolic Ca2+ levels0.47
    5Platelet activation, signaling and aggregation
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TRPC7
        Calcium channels

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TRPC7
        Intracellular Calcium Signaling


    5/15        Reactome Pathways for TRPC7 (see all 15)
        GPCR downstream signaling
    Hemostasis
    Developmental Biology
    Gastrin-CREB signalling pathway via PKC and MAPK
    Platelet homeostasis



    TRPC7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRPC7

    4 Interacting proteins for TRPC7 (Q9HCX43) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MX1P205913I2D: score=3 
    ITPR3Q145733I2D: score=1 
    TRPC3Q135073I2D: score=1 
    TRPC6Q9Y2103I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0006816calcium ion transport ----
    GO:0006828manganese ion transport IEA--
    GO:0007411axon guidance TAS--
    GO:0007596blood coagulation TAS--

    TRPC7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRPC7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for TRPC7

    10/844 HMDB Compounds for TRPC7 (see all 844)    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----

    4 IUPHAR Ligands for TRPC7 (TRPC7)    About this table 
    LigandTypeActionAffinityPubmed IDs
    SKF96365
    Channel blockerNone--
    amiloride
    Channel blockerNone--
    La3+
    Channel blockerNone--
    2-APB
    Channel blockerNone--

    3 Novoseek inferred chemical compound relationships for TRPC7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thapsigargin 47.8 2 10488066 (1)
    calcium 46.6 15 10541222 (1), 10550622 (1), 12356946 (1), 11126000 (1) (see all 11)
    inositol 1,4,5 trisphosphate 32.6 1 15104179 (1)

    Search CenterWatch for drugs/clinical trials and news about TRPC7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRPC7 gene (3 alternative transcripts): 
    NM_001167576.1  NM_001167577.1  NM_020389.2  

    Unigene Cluster for TRPC7:

    Transient receptor potential cation channel, subfamily C, member 7
    Hs.591263  [show with all ESTs]
    Unigene Representative Sequence: NM_020389
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000513104(uc010jef.2 uc010jeg.2 uc003lbn.2) ENST00000509288
    ENST00000503275 ENST00000352189 ENST00000514963 ENST00000378459 ENST00000502753
    ENST00000514282 ENST00000355180(uc010jeh.2) ENST00000426057(uc010jej.2 uc010jei.2)

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    Additional mRNA sequence: 

    AJ272034.1 AJ421783.1 AJ549088.1 AJ549089.1 AJ549090.1 AY167926.1 AY167927.1 BC128185.1 
    BC128186.1 

    4 DOTS entries:

    DT.101981146  DT.92051190  DT.100008625  DT.100008626 

    19 AceView cDNA sequences:

    AJ549090 AY167926 BX279646 AJ272034 AJ549089 NM_020389 AY167927 AJ421783 
    BI826927 AJ549088 BG217935 BI765642 CD630109 CD630114 CD630119 CD630122 
    CD630115 CD630111 CD630118 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TRPC7 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b
    SP1:                                            -                                 
    SP2:              -                             -                                 
    SP3:        -                                   -                                 
    SP4:              -                             -                                 
    SP5:        -     -                             -                                 


    ECgene alternative splicing isoforms for TRPC7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRPC7 expression in normal human tissues (normalized intensities)      TRPC7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TRPC7 Expression
    About this image


    TRPC7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Eye (Sensory Organs)
             Mature Horizontal Cells Inner Nuclear Layer

    See TRPC7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRPC7

    SOURCE GeneReport for Unigene cluster: Hs.591263
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TRPC7 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trpc71 , 5 transient receptor potential cation channel, subfamily more1, 5 90.53(n)1
    98.14(a)1
      13 (30.27 cM)5
    269461  NM_012035.21  NP_036165.11 
     567731135 
    chicken
    (Gallus gallus)
    Aves TRPC71 transient receptor potential cation channel, subfamily more 81.16(n)
    94.59(a)
      427641  XM_425214.3  XP_425214.3 
    lizard
    (Anolis carolinensis)
    Reptilia TRPC76
    Uncharacterized protein
    93(a)
    1 ↔ 1
    GL343223.1(1745057-1913136)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5675661 short transient receptor potential channel 7-like 74.94(n)
    84.89(a)
      567566  XM_690863.2  XP_695955.2 


    ENSEMBL Gene Tree for TRPC7 (if available)
    TreeFam Gene Tree for TRPC7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRPC7 gene
    TRPC42  TRPC12  TRPC62  TRPC52  TRPC32  
    5 SIMAP similar genes for TRPC7 using alignment to 9 protein entries:     TRPC7_HUMAN (see all proteins):
    TRP7    TRPC3    TRPC6    TRPC4    TRPC5

    TRPC7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2850 SNPs in TRPC7 are shown (see all 2850)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs768872391,2
    --135549032(+) AGTGGG/TCTGGG 3 -- ut310--------
    rs1152466771,2
    C,F--135549043(+) GACCCC/TTCCCC 3 -- ut311Minor allele frequency- T:0.03WA 118
    rs2014000421,2
    C,F--135549206(+) CAGGTC/TTGCCA 6 N D mis11Minor allele frequency- T:0.00EU 579
    rs1490405871,2
    C--135549339(+) AAGCTC/TGGGGC 3 -- int10--------
    rs1841484661,2
    --135549454(+) CAGAAC/TCACCC 3 -- int10--------
    rs1871177961,2
    --135549581(+) GTCTAC/GCACTT 3 -- int10--------
    rs747551451,2
    C,F--135549679(+) CATTGC/ATTTTG 3 -- int11Minor allele frequency- A:0.06WA 118
    rs1165002041,2
    F--135549711(+) TCATTG/ATTATT 3 -- int11Minor allele frequency- A:0.02WA 118
    rs1911719361,2
    C--135549752(+) AGAGAA/GTGGCT 3 -- int10--------
    rs1825506791,2
    --135549759(+) GGCTCA/GGCACA 3 -- int10--------

    HapMap Linkage Disequilibrium report for TRPC7 (135548999 - 135732730 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TRPC7:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2667747CNV Deletion23128226
    esv2661991CNV Deletion23128226
    esv271457CNV Insertion20981092
    nsv508381CNV Loss20534489

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603749    OMIM disorders: --

    3 diseases for TRPC7:    About MalaCards
    myelodysplastic syndromes    gingivitis    neuronitis


    TRPC7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TRPC7
    Human Genome Epidemiology (HuGE) Navigator: TRPC7 (6 documents)

    Export disorders for TRPC7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRPC7 gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with TRPC7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx. (PubMed id 11805119)1, 3, 9 Riccio A.... Pangalos M.N. (2002)
    2. Functional regulation of transient receptor potential canonical 7 by cGMP-dependent protein kinase Ialpha. (PubMed id 21402151)1, 2 Yuasa K.... Tsuji A. (2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis. (PubMed id 19240791)1, 4 Graubert T.A....Walter M.J. (2009)
    5. MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC. (PubMed id 15757897)1, 2 Lussier M.P....Boulay G. (2005)
    6. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. (PubMed id 16382100)1, 3 Clapham D.E....Schultz G. (2005)
    7. TRPC7. (PubMed id 17217055)1, 9 Numaga T....Mori Y. (2007)
    8. Endogenous TRPC1, TRPC3, and TRPC7 proteins combine to form native store-operated channels in HEK-293 cells. (PubMed id 15972814)1, 9 Zagranichnaya T.K....Villereal M.L. (2005)
    9. Canonical transient receptor potential TRPC7 can function as both a receptor- and store-operated channel in HEK-293 cells. (PubMed id 15342342)1, 9 Lievremont J.P....Putney J.W. (2004)
    10. A pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7. (PubMed id 19812035)1, 9 Miyagi K....Mori Y. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57113 HGNC: 20754 AceView: TRPC7 Ensembl:ENSG00000069018 euGenes: HUgn57113
    ECgene: TRPC7 H-InvDB: TRPC7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRPC7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRPC7 gene:
    Search GeneIP for patents involving TRPC7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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