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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TRPC7 Gene

protein-coding GIFtS: 56
GCID: GC05M135549

transient receptor potential cation channel, subfamily C,...

Explore 3 diseases affiliated with
TRPC7 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, and/or ¹¹Nature:405,311-319 and CroW21)
About This Section

Aliases
Transient Receptor Potential Cation Channel, Subfamily C, Member 7¹ ²		Likley Ortholog Of Mouse Transient Receptor Potential Cation Channel, Subfamily C, Member 7²
Transient Receptor Protein 7² ³		Putative Capacitative Calcium Channel²
TRP-7² ³		Short Transient Receptor Potential Channel 7²
TRP7² ³		TrpC7³
HTRP7¹		KNP3⁵
Transient Receptor Potential-Related Channel 7, A Novel Putative Ca2+ Channel Protein11		TRPM2⁵

External Ids:	HGNC: 20754¹	Entrez Gene: 57113²	Ensembl: ENSG00000069018⁷	OMIM: 603749⁵	UniProtKB: Q9HCX4³

Export aliases for TRPC7 gene to outside databases

Previous GC identifers: GC05M135424 GC05M136212 GC05M135579 GC05M135625 GC05M135577 GC05M130737

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TRPC7_HUMAN, Q9HCX4

Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a

phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors.

Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion

Gene Wiki entry for TRPC7

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_034772.6

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TRPC7 gene promoter:
LHX3b/Lhx3b AML1a NRSF form 1 STAT1beta MIF-1 Nkx2-5 NRSF form 2 STAT1alpha RORalpha1 LHX3a/Lhx3a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRPC7 promoter sequence

Search SABiosciences Chromatin IP Primers for TRPC7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRPC7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1 Ensembl cytogenetic band: 5q31.1 HGNC cytogenetic band: 5q31.2
Nature(405: 311-319) cytogenetic band: 21q22.3

TRPC7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRPC7 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

(about GC identifiers)

GC05M135549:	GeneLoc	Nature:405,311-319
Start:	135,548,999 bp from pter	31,282,531 bp from centromere
End:	135,701,225 bp from pter	31,372,356 bp from centromere
Size:	152,227 bases	89,826 bases
Orientation:	minus strand	plus strand

Whole chromosome sequencing:
cDNA sequence:	AB001535
genomic clones:	KUD99F9 to KB68A7

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TRPC7_HUMAN, Q9HCX4 (See protein sequence)

Recommended Name: Short transient receptor potential channel 7

Size: 862 amino acids; 99562 Da

Subunit: Interacts with MX1 and RNF24. Interacts (via ANK-repeat domains) with PRKG1

Subcellular location: Cell membrane; Multi-pass membrane protein. Nucleus envelope

Secondary accessions: A1A4Z4 F5H5U9 Q70T26 Q8IWP7

Alternative splicing: 3 isoforms: Q9HCX4-1 Q9HCX4-2 Q9HCX4-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRPC7: NX_Q9HCX4

Post-translational modifications:

Phosphorylation by PRKG1 at Thr-15 negatively regulates TRPC7 activity¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9HCX4

TRPC7 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001161048.1 NP_001161049.1 NP_065122.1

ENSEMBL proteins:

ENSP00000426070 ENSP00000421571 ENSP00000330322 ENSP00000426870 ENSP00000367720

ENSP00000424854 ENSP00000347312 ENSP00000441628

Reactome Protein details: Q9HCX4
Human Recombinant Protein Products for TRPC7:

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	Uscn Proteins for TRPC7

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005635	nuclear envelope	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

TRPC7 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for TRPC7

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TRPC7 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR005463 TRPC7_channel

IPR002153 TRPC_channel

IPR020683 Ankyrin_rpt-contain_dom

IPR005821 Ion_trans_dom

IPR004729 TRP_channel

Graphical View of Domain Structure for InterPro Entry Q9HCX4

ProtoNet protein and cluster: Q9HCX4

4 Blocks protein families:

IPB002110 Ankyrin repeat signature

IPB002153 Transient receptor potential family signature

IPB005463 Transient receptor potential channel 7 signature

IPB013555 Transient receptor ion channel II

UniProtKB/Swiss-Prot: TRPC7_HUMAN, Q9HCX4

Similarity: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC7 sub-subfamily

Similarity: Contains 4 ANK repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TRPC7_HUMAN, Q9HCX4

Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a

phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors.

Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion

Genatlas biochemistry entry for TRPC7:

transient receptor potential non voltage-channel 7,Drosophila store-operated channel (Soc) homolog,expressed in brain

activated by calcium store depletion,component of the capacitative calcium entry,channels (homo or heterotetramer)

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005262	calcium channel activity	IEA	--
GO:0005515	protein binding	IPI	--

TRPC7 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for TRPC7:

Decreased G3BP1 protein expres

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Trpc7):

vision/eye

TRPC7 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Trpc7^tm1.1Kofu for TRPC7

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TRPC7

miRNA Products:		OriGene 3'-UTR Clone: TRPC7 Browse MicroRNA Expression Plasmids
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		hsa-miR-3673 hsa-miR-224 hsa-miR-138 hsa-miR-3176 hsa-miR-3922-3p
		Browse SwitchGear 3'UTR luciferase reporter plasmids

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC7

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Platelet activation, signaling and aggregation

Platelet activation, signaling and aggregation

1.00

Hemostasis

0.43

Role of second messengers in netrin-1 signaling

Role of second messengers in netrin-1 signaling

1.00

Activation of TRPC channels by Netrin-1

0.60

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Platelet calcium homeostasis

Platelet calcium homeostasis

1.00

Elevation of cytosolic Ca2+ levels

0.47

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for TRPC7

Calcium channels

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TRPC7

Intracellular Calcium Signaling

5/16 Reactome Pathways for TRPC7 (see all 16)

	Developmental Biology
	Platelet homeostasis
	Elevation of cytosolic Ca2+ levels
	Signal Transduction
	G alpha (q) signalling events

TRPC7 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TRPC7

4 Interacting proteins for TRPC7 (Q9HCX4³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MX1	P20591³	I2D: score=3
ITPR3	Q14573³	I2D: score=1
TRPC3	Q13507³	I2D: score=1
TRPC6	Q9Y210³	I2D: score=1

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006816	calcium ion transport	--	--
GO:0006828	manganese ion transport	IEA	--
GO:0007411	axon guidance	TAS	--
GO:0007596	blood coagulation	TAS	--
GO:0030168	platelet activation	TAS	--

TRPC7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TRPC7 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TRPC7

10/844 HMDB Compounds for TRPC7 (see all 844) About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
DG(14:0/14:0/0:0)	DAG(14:0/14:0) (see all 9)	--	--
DG(14:0/14:1(9Z)/0:0)	DAG(14:0/14:1) (see all 15)	--	--
DG(14:0/15:0/0:0)	Diacylglycerol(29:0) (see all 9)	--	--
DG(14:0/16:0/0:0)	DAG(30:0) (see all 9)	--	--
DG(14:0/16:1(9Z)/0:0)	DG(30:1) (see all 15)	--	--
DG(14:0/18:0/0:0)	DG(14:0/18:0) (see all 9)	--	--
DG(14:0/18:1(11Z)/0:0)	Diacylglycerol (see all 15)	--	--
DG(14:0/18:1(9Z)/0:0)	1-myristoyl-2-oleoyl-sn-glycerol (see all 15)	--	--
DG(14:0/18:2(9Z,12Z)/0:0)	DAG(14:0/18:2n6) (see all 15)	--	--

3 Novoseek chemical compound relationships for TRPC7 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
thapsigargin	47.8	2	10488066 (1)
calcium	46.6	15	10541222 (1), 10550622 (1), 12356946 (1), 11126000 (1) (see all 11)
inositol 1,4,5 trisphosphate	32.6	1	15104179 (1)

Search CenterWatch for drugs/clinical trials and news about TRPC7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TRPC7 gene (3 alternative transcripts):

NM_001167576.1 NM_001167577.1 NM_020389.2

Unigene Cluster for TRPC7:

Transient receptor potential cation channel, subfamily C, member 7

Hs.591263 [show with all ESTs]

Unigene Representative Sequence: NM_020389

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000513104(uc010jef.2 uc010jeg.2 uc003lbn.2) ENST00000509288

ENST00000503275 ENST00000352189 ENST00000514963 ENST00000378459 ENST00000502753

ENST00000355180(uc010jeh.2) ENST00000426057(uc010jej.2 uc010jei.2)

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Additional cDNA sequence:

AJ272034.1 AJ421783.1 AJ549088.1 AJ549089.1 AJ549090.1 AY167926.1 AY167927.1 BC128185.1

BC128186.1

4 DOTS entries:

DT.101981146 DT.92051190 DT.100008625 DT.100008626

19 AceView cDNA sequences:

BX279646 AJ549089 AY167926 AJ549090 AY167927 NM_020389 AJ272034 BI826927

BI765642 AJ549088 BG217935 AJ421783 CD630109 CD630114 CD630119 CD630122

CD630115 CD630111 CD630118

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TRPC7 (see all 7) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11a	·	11b
SP1:															-
SP2:					-										-
SP3:			-												-
SP4:					-										-
SP5:			-		-										-

ECgene alternative splicing isoforms for TRPC7

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRPC7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

TRPC7 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Mature Horizontal Cells

Horizontal, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TRPC7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRPC7

SOURCE GeneReport for Unigene cluster: Hs.591263

SABiosciences Custom PCR Arrays for TRPC7

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRPC7 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRPC7

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC7

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TRPC7 gene from 5/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Trpc7^{1 , 5}	transient receptor potential cation channel, subfamily more^{1, 5}	90.53(n)¹ 98.14(a)¹		13 (30.27 cM)⁵ 26946¹ NM_012035.2¹ NP_036165.1¹ 56773113⁵
chicken (Gallus gallus)	Aves	TRPC7¹	transient receptor potential cation channel, subfamily more	81.16(n) 94.59(a)		427641 XM_425214.3 XP_425214.3
lizard (Anolis carolinensis)	Reptilia	TRPC7⁶	--	93(a)	1 ↔ 1	GL343223.1(1745120-1896183)
zebrafish (Danio rerio)	Actinopterygii	LOC567566¹	short transient receptor potential channel 7-like	74.94(n) 84.89(a)		567566 XM_690863.2 XP_695955.2
honey bee (Apis mellifera)	Insecta	--	--	25(a)	1 → many	GroupUn.1268(2616-22451)

ENSEMBL Gene Tree for TRPC7 (if available)
TreeFam Gene Tree for TRPC7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TRPC7 gene

TRPC4² TRPC1² TRPC6² TRPC5² TRPC3²

5 SIMAP similar genes for TRPC7 using alignment to 9 protein entries: TRPC7_HUMAN (see all proteins):

TRP7 TRPC3 TRPC6 TRPC4 TRPC5

TRPC7 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 21 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs140562618^1,2	C	--	135548525(+)	`GGATT-/TTGTTGTT`	4	--	ds500¹		0	--	--	--	--
rs140070705^1,2		--	135548561(+)	`AGTACA/GGTTTT`	4	--	ds500¹		0	--	--	--	--
rs185858568^1,2		--	135548660(+)	`GATCAC/TAGGTC`	4	--	ds500¹		0	--	--	--	--
rs200742512^1,2		--	135548692(+)	`GTGTT-/GGGGGT`	4	--	ds500¹		0	--	--	--	--
rs188663150^1,2		--	135548693(+)	`TGTTGG/TGGGTG`	4	--	ds500¹		0	--	--	--	--
rs145509805^1,2		--	135548694(+)	`GTTGGA/GGGTGG`	4	--	ds500¹		0	--	--	--	--
rs181092955^1,2		--	135548706(+)	`AGGGAA/GGGAGT`	4	--	ds500¹		0	--	--	--	--
rs186130478^1,2		--	135548801(+)	`GTGCAC/TCCAAG`	4	--	ds500¹		0	--	--	--	--
rs147719706^1,2		--	135548873(+)	`CACTCA/GTCAGG`	4	--	ds500¹		0	--	--	--	--
rs139078754^1,2		--	135548918(+)	`CTTACC/TCAACC`	4	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TRPC7 (135548999 - 135701225 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TRPC7: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TRPC7 for disorders           About GeneDecksing

OMIM gene information: 603749    OMIM disorders: --

3 diseases for TRPC7:    About MalaCards

myelodysplastic syndrome gingivitis neuronitis

Human Genome Epidemiology (HuGE) Navigator: TRPC7 (6 documents)

Export disorders for TRPC7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TRPC7 gene, integrated from 9 sources (see all 39):
(articles sorted by number of sources associating them with TRPC7)

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Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx. (PubMed id 11805119)^{1, 3, 9} Riccio A.... Pangalos M.N. (2002)
Functional regulation of transient receptor potential canonical 7 by cGMP-dependent protein kinase Ialpha. (PubMed id 21402151)^{1, 2} Yuasa K.... Tsuji A. (2011)
MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC. (PubMed id 15757897)^{1, 2} Lussier M.P....Boulay G. (2005)
International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. (PubMed id 16382100)^{1, 3} Clapham D.E....Schultz G. (2005)
TRPC7. (PubMed id 17217055)^{1, 9} Numaga T....Mori Y. (2007)
Endogenous TRPC1, TRPC3, and TRPC7 proteins combine to form native store-operated channels in HEK-293 cells. (PubMed id 15972814)^{1, 9} Zagranichnaya T.K....Villereal M.L. (2005)
Canonical transient receptor potential TRPC7 can function as both a receptor- and store-operated channel in HEK-293 cells. (PubMed id 15342342)^{1, 9} Lievremont J.P....Putney J.W. (2004)
A pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7. (PubMed id 19812035)^{1, 9} Miyagi K....Mori Y. (2009)
The role of canonical transient receptor potential 7 in B-cell receptor-activated channels. (PubMed id 16123040)^{1, 9} Lievremont J.P....Putney J.W. (2005)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 57113	HGNC: 20754	AceView: TRPC7	Ensembl:ENSG00000069018	euGenes: HUgn57113
ECgene: TRPC7	H-InvDB: TRPC7

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TRPC7	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TRPC7 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TRPC7 gene:
Search GeneIP for patents involving TRPC7

GeneCards and IP:
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