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Aliases for TRPC7 Gene

Aliases for TRPC7 Gene

  • Transient Receptor Potential Cation Channel, Subfamily C, Member 7 2 3
  • Transient Receptor Protein 7 3 4
  • TRP-7 3 4
  • HTRP7 3 4
  • TRP7 3 4
  • Likley Ortholog Of Mouse Transient Receptor Potential Cation Channel, Subfamily C, Member 7 3
  • Short Transient Receptor Potential Channel 7 3
  • Putative Capacitative Calcium Channel 3
  • TRPC7 4
  • TRPM2 6
  • KNP3 6

External Ids for TRPC7 Gene

Summaries for TRPC7 Gene

GeneCards Summary for TRPC7 Gene

TRPC7 (Transient Receptor Potential Cation Channel, Subfamily C, Member 7) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and L1CAM interactions. GO annotations related to this gene include calcium channel activity. An important paralog of this gene is TRPC6.

UniProtKB/Swiss-Prot for TRPC7 Gene

  • Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion.

Gene Wiki entry for TRPC7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRPC7 Gene

Genomics for TRPC7 Gene

Genomic Location for TRPC7 Gene

Start:
136,212,770 bp from pter
End:
136,365,537 bp from pter
Size:
152,768 bases
Orientation:
Minus strand

Genomic View for TRPC7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRPC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRPC7 Gene

Proteins for TRPC7 Gene

  • Protein details for TRPC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCX4-TRPC7_HUMAN
    Recommended name:
    Short transient receptor potential channel 7
    Protein Accession:
    Q9HCX4
    Secondary Accessions:
    • A1A4Z4
    • F5H5U9
    • Q70T26
    • Q8IWP7

    Protein attributes for TRPC7 Gene

    Size:
    862 amino acids
    Molecular mass:
    99562 Da
    Quaternary structure:
    • Interacts with MX1 and RNF24. Interacts (via ANK-repeat domains) with PRKG1.

    Alternative splice isoforms for TRPC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRPC7 Gene

Proteomics data for TRPC7 Gene at MOPED

Post-translational modifications for TRPC7 Gene

  • Phosphorylation by PRKG1 at Thr-15 negatively regulates TRPC7 activity.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn514

Other Protein References for TRPC7 Gene

No data available for DME Specific Peptides for TRPC7 Gene

Domains for TRPC7 Gene

Gene Families for TRPC7 Gene

HGNC:
  • TRP :Voltage-gated ion channels / Transient receptor potential cation channels
IUPHAR :

UniProtKB/Swiss-Prot:

TRPC7_HUMAN
Family:
  • Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC7 sub-subfamily.:
    • Q9HCX4
Similarity:
  • Contains 4 ANK repeats.:
    • Q9HCX4
genes like me logo Genes that share domains with TRPC7: view

Function for TRPC7 Gene

Molecular function for TRPC7 Gene

GENATLAS Biochemistry: transient receptor potential non voltage-channel 7,Drosophila store-operated channel (Soc) homolog,expressed in brain activated by calcium store depletion,component of the capacitative calcium entry,channels (homo or heterotetramer)
UniProtKB/Swiss-Prot Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion.

Gene Ontology (GO) - Molecular Function for TRPC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005262 calcium channel activity --
GO:0005488 binding --
GO:0005515 protein binding IPI 21402151
GO:0015279 store-operated calcium channel activity IBA --
genes like me logo Genes that share ontologies with TRPC7: view

Phenotypes for TRPC7 Gene

genes like me logo Genes that share phenotypes with TRPC7: view

Animal Models for TRPC7 Gene

MGI Knock Outs for TRPC7:

miRNA for TRPC7 Gene

miRTarBase miRNAs that target TRPC7

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TRPC7 Gene

Localization for TRPC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRPC7 Gene

Cell membrane; Multi-pass membrane protein. Nucleus envelope.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRPC7 Gene COMPARTMENTS Subcellular localization image for TRPC7 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytoskeleton 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TRPC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005635 nuclear envelope IEA --
GO:0005801 cis-Golgi network IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
genes like me logo Genes that share ontologies with TRPC7: view

Pathways for TRPC7 Gene

genes like me logo Genes that share pathways with TRPC7: view

Pathways by source for TRPC7 Gene

1 KEGG pathway for TRPC7 Gene

Gene Ontology (GO) - Biological Process for TRPC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0006816 calcium ion transport --
GO:0006828 manganese ion transport IBA --
GO:0007411 axon guidance TAS --
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with TRPC7: view

Compounds for TRPC7 Gene

(844) HMDB Compounds for TRPC7 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available
DG(14:0/15:0/0:0)
  • Diacylglycerol(29:0)
Not Available
DG(14:0/16:0/0:0)
  • DAG(30:0)
Not Available

(4) IUPHAR Ligand for TRPC7 Gene

Ligand Type Action Affinity Pubmed IDs
SKF96365 Channel blocker None
amiloride Channel blocker None
La3+ Channel blocker None
2-APB Channel blocker None

(3) Novoseek inferred chemical compound relationships for TRPC7 Gene

Compound -log(P) Hits PubMed IDs
thapsigargin 47.8 1
calcium 46.6 11
inositol 1,4,5 trisphosphate 32.6 1
genes like me logo Genes that share compounds with TRPC7: view

Transcripts for TRPC7 Gene

Unigene Clusters for TRPC7 Gene

Transient receptor potential cation channel, subfamily C, member 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRPC7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b
SP1: -
SP2: - -
SP3: - -
SP4: - -
SP5: - - -
SP6: - - - -
SP7:

Relevant External Links for TRPC7 Gene

GeneLoc Exon Structure for
TRPC7
ECgene alternative splicing isoforms for
TRPC7

Expression for TRPC7 Gene

mRNA expression in normal human tissues for TRPC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRPC7 Gene

This gene is overexpressed in Testis (9.6), Pituitary (8.4), Brain - Hypothalamus (6.4), Kidney - Cortex (5.6), and Brain - Putamen (basal ganglia) (4.1).

SOURCE GeneReport for Unigene cluster for TRPC7 Gene Hs.591263

genes like me logo Genes that share expressions with TRPC7: view

Orthologs for TRPC7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRPC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRPC7 36
  • 99.61 (n)
  • 99.88 (a)
TRPC7 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRPC7 36
  • 94.04 (n)
  • 98.96 (a)
TRPC7 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRPC7 36
  • 93.34 (n)
  • 98.49 (a)
TRPC7 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trpc7 36
  • 90.53 (n)
  • 98.14 (a)
Trpc7 16
Trpc7 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRPC7 37
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 95 (a)
OneToMany
-- 37
  • 86 (a)
OneToMany
-- 37
  • 94 (a)
OneToMany
-- 37
  • 93 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Trpc7 36
  • 90.8 (n)
  • 98.49 (a)
chicken
(Gallus gallus)
Aves TRPC7 36
  • 81.18 (n)
  • 94.6 (a)
TRPC7 37
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRPC7 37
  • 93 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii TRPC7 (1 of 3) 37
  • 82 (a)
OneToMany
TRPC7 (2 of 3) 37
  • 84 (a)
OneToMany
TRPC7 (3 of 3) 37
  • 89 (a)
OneToMany
trpc7a 36
  • 74.92 (n)
  • 84.98 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 45 (a)
OneToMany
Species with no ortholog for TRPC7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRPC7 Gene

ENSEMBL:
Gene Tree for TRPC7 (if available)
TreeFam:
Gene Tree for TRPC7 (if available)

Paralogs for TRPC7 Gene

Paralogs for TRPC7 Gene

Selected SIMAP similar genes for TRPC7 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with TRPC7: view

Variants for TRPC7 Gene

Sequence variations from dbSNP and Humsavar for TRPC7 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs171101 -- 136,282,516(-) TGTTA(C/T)ACCTA intron-variant
rs180767 -- 136,283,031(-) CTTGG(C/T)ACACT intron-variant
rs180768 -- 136,280,021(-) CACCA(C/T)GCCCA intron-variant
rs180769 -- 136,279,927(-) GATCC(A/G)CCCAC intron-variant
rs180770 -- 136,304,479(-) gtgga(C/T)aggca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRPC7 Gene

Variant ID Type Subtype PubMed ID
nsv508381 CNV Loss 20534489
esv271457 CNV Insertion 20981092
esv2661991 CNV Deletion 23128226
esv2667747 CNV Deletion 23128226

Relevant External Links for TRPC7 Gene

HapMap Linkage Disequilibrium report
TRPC7

Disorders for TRPC7 Gene

Relevant External Links for TRPC7

Genetic Association Database (GAD)
TRPC7
Human Genome Epidemiology (HuGE) Navigator
TRPC7
genes like me logo Genes that share disorders with TRPC7: view

No data available for UniProtKB/Swiss-Prot for TRPC7 Gene

Publications for TRPC7 Gene

  1. Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx. (PMID: 11805119) Riccio A. … Pangalos M.N. (J. Biol. Chem. 2002) 2 3 23
  2. Canonical transient receptor potential TRPC7 can function as both a receptor- and store-operated channel in HEK-293 cells. (PMID: 15342342) LiA"vremont J.P. … Putney J.W. (Am. J. Physiol., Cell Physiol. 2004) 3 23
  3. Endogenous TRPC1, TRPC3, and TRPC7 proteins combine to form native store-operated channels in HEK-293 cells. (PMID: 15972814) Zagranichnaya T.K. … Villereal M.L. (J. Biol. Chem. 2005) 3 23
  4. TRPC7. (PMID: 17217055) Numaga T. … Mori Y. (Handb Exp Pharmacol 2007) 3 23
  5. A pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7. (PMID: 19812035) Miyagi K. … Mori Y. (J. Biol. Chem. 2009) 3 23

Products for TRPC7 Gene

Sources for TRPC7 Gene

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