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Aliases for TRPC7 Gene

Aliases for TRPC7 Gene

  • Transient Receptor Potential Cation Channel Subfamily C Member 7 2 3
  • Transient Receptor Potential Cation Channel, Subfamily C, Member 7 2 3 5
  • Transient Receptor Protein 7 3 4
  • TRP-7 3 4
  • HTRP7 3 4
  • TRP7 3 4
  • Likley Ortholog Of Mouse Transient Receptor Potential Cation Channel, Subfamily C, Member 7 3
  • Putative Capacitative Calcium Channel 3
  • TrpC7 4

External Ids for TRPC7 Gene

Previous GeneCards Identifiers for TRPC7 Gene

  • GC05M135424
  • GC05M135579
  • GC05M135625
  • GC05M135577
  • GC05M135549
  • GC05M130737

Summaries for TRPC7 Gene

GeneCards Summary for TRPC7 Gene

TRPC7 (Transient Receptor Potential Cation Channel Subfamily C Member 7) is a Protein Coding gene. Among its related pathways are CREB Pathway and Developmental Biology. GO annotations related to this gene include binding and calcium channel activity. An important paralog of this gene is TRPC6.

UniProtKB/Swiss-Prot for TRPC7 Gene

  • Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion.

Gene Wiki entry for TRPC7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRPC7 Gene

Genomics for TRPC7 Gene

Regulatory Elements for TRPC7 Gene

Enhancers for TRPC7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRPC7 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRPC7 Gene

Chromosome:
5
Start:
136,212,765 bp from pter
End:
136,365,537 bp from pter
Size:
152,773 bases
Orientation:
Minus strand

Genomic View for TRPC7 Gene

Genes around TRPC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRPC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRPC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRPC7 Gene

Proteins for TRPC7 Gene

  • Protein details for TRPC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCX4-TRPC7_HUMAN
    Recommended name:
    Short transient receptor potential channel 7
    Protein Accession:
    Q9HCX4
    Secondary Accessions:
    • A1A4Z4
    • F5H5U9
    • Q70T26
    • Q8IWP7

    Protein attributes for TRPC7 Gene

    Size:
    862 amino acids
    Molecular mass:
    99562 Da
    Quaternary structure:
    • Interacts with MX1 and RNF24. Interacts (via ANK-repeat domains) with PRKG1.

    Alternative splice isoforms for TRPC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRPC7 Gene

Proteomics data for TRPC7 Gene at MOPED

Post-translational modifications for TRPC7 Gene

  • Phosphorylation by PRKG1 at Thr-15 negatively regulates TRPC7 activity.
  • Glycosylation at Asn 514
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for TRPC7 Gene

Domains & Families for TRPC7 Gene

Gene Families for TRPC7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HCX4

UniProtKB/Swiss-Prot:

TRPC7_HUMAN :
  • Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC7 sub-subfamily.
  • Contains 4 ANK repeats.
Family:
  • Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC7 sub-subfamily.
Similarity:
  • Contains 4 ANK repeats.
genes like me logo Genes that share domains with TRPC7: view

Function for TRPC7 Gene

Molecular function for TRPC7 Gene

GENATLAS Biochemistry:
transient receptor potential non voltage-channel 7,Drosophila store-operated channel (Soc) homolog,expressed in brain activated by calcium store depletion,component of the capacitative calcium entry,channels (homo or heterotetramer)
UniProtKB/Swiss-Prot Function:
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion.
genes like me logo Genes that share phenotypes with TRPC7: view

Animal Models for TRPC7 Gene

MGI Knock Outs for TRPC7:

miRNA for TRPC7 Gene

miRTarBase miRNAs that target TRPC7

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRPC7 Gene

Localization for TRPC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRPC7 Gene

Cell membrane; Multi-pass membrane protein. Nucleus envelope.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRPC7 Gene COMPARTMENTS Subcellular localization image for TRPC7 gene
Compartment Confidence
plasma membrane 5
cytosol 4
nucleus 4
cytoskeleton 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TRPC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IBA --
GO:0005887 integral component of plasma membrane IBA --
genes like me logo Genes that share ontologies with TRPC7: view

Pathways & Interactions for TRPC7 Gene

genes like me logo Genes that share pathways with TRPC7: view

Pathways by source for TRPC7 Gene

Gene Ontology (GO) - Biological Process for TRPC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006828 manganese ion transport IBA --
GO:0007411 axon guidance TAS --
GO:0007596 blood coagulation TAS --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with TRPC7: view

No data available for SIGNOR curated interactions for TRPC7 Gene

Drugs & Compounds for TRPC7 Gene

(5) Drugs for TRPC7 Gene - From: DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amiloride Approved Pharma Channel blocker, blocker 47
2-APB Pharma Antagonist, Pore Blocker IP3 receptor antagonist. Also TRP channel modulator 0
calcium Nutra 0
La<sup>3+</sup> Pharma Pore Blocker 0
SKF96365 Pharma Pore Blocker 0

(6) Additional Compounds for TRPC7 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with TRPC7: view

Transcripts for TRPC7 Gene

Unigene Clusters for TRPC7 Gene

Transient receptor potential cation channel, subfamily C, member 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRPC7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b
SP1: -
SP2: - -
SP3: - -
SP4: - -
SP5: - - -
SP6: - - - -
SP7:

Relevant External Links for TRPC7 Gene

GeneLoc Exon Structure for
TRPC7
ECgene alternative splicing isoforms for
TRPC7

Expression for TRPC7 Gene

mRNA expression in normal human tissues for TRPC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRPC7 Gene

This gene is overexpressed in Testis (x9.6), Pituitary (x8.4), Brain - Hypothalamus (x6.4), Kidney - Cortex (x5.6), and Brain - Putamen (basal ganglia) (x4.1).

SOURCE GeneReport for Unigene cluster for TRPC7 Gene Hs.591263

genes like me logo Genes that share expression patterns with TRPC7: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TRPC7 Gene

Orthologs for TRPC7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRPC7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRPC7 35
  • 94.04 (n)
  • 98.96 (a)
TRPC7 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRPC7 35
  • 93.34 (n)
  • 98.49 (a)
TRPC7 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trpc7 35
  • 90.53 (n)
  • 98.14 (a)
Trpc7 16
Trpc7 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRPC7 35
  • 99.61 (n)
  • 99.88 (a)
TRPC7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trpc7 35
  • 90.8 (n)
  • 98.49 (a)
oppossum
(Monodelphis domestica)
Mammalia TRPC7 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 95 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
chicken
(Gallus gallus)
Aves TRPC7 35
  • 81.18 (n)
  • 94.6 (a)
TRPC7 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRPC7 36
  • 93 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii trpc7a 35
  • 74.92 (n)
  • 84.98 (a)
TRPC7 (1 of 3) 36
  • 82 (a)
OneToMany
TRPC7 (2 of 3) 36
  • 84 (a)
OneToMany
TRPC7 (3 of 3) 36
  • 89 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for TRPC7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRPC7 Gene

ENSEMBL:
Gene Tree for TRPC7 (if available)
TreeFam:
Gene Tree for TRPC7 (if available)

Paralogs for TRPC7 Gene

Paralogs for TRPC7 Gene

genes like me logo Genes that share paralogs with TRPC7: view

Variants for TRPC7 Gene

Sequence variations from dbSNP and Humsavar for TRPC7 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs871385 -- 136,233,776(-) TAATC(A/G)CTCAC intron-variant
rs885232 -- 136,325,598(-) ATTCA(A/G)TCCTC intron-variant
rs889010 -- 136,237,222(-) TTGTT(G/T)AGGAC intron-variant
rs889011 -- 136,236,957(-) TTGTC(C/T)GCTGA intron-variant
rs889012 -- 136,219,028(-) ACCAT(A/C)TTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRPC7 Gene

Variant ID Type Subtype PubMed ID
nsv508381 CNV Loss 20534489
esv271457 CNV Insertion 20981092
esv2661991 CNV Deletion 23128226
esv2667747 CNV Deletion 23128226

Variation tolerance for TRPC7 Gene

Residual Variation Intolerance Score: 4.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.96; 36.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRPC7 Gene

HapMap Linkage Disequilibrium report
TRPC7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRPC7 Gene

Disorders for TRPC7 Gene

Relevant External Links for TRPC7

Genetic Association Database (GAD)
TRPC7
Human Genome Epidemiology (HuGE) Navigator
TRPC7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRPC7

No disorders were found for TRPC7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRPC7 Gene

Publications for TRPC7 Gene

  1. Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx. (PMID: 11805119) Riccio A. … Pangalos M.N. (J. Biol. Chem. 2002) 2 3 23 67
  2. A pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7. (PMID: 19812035) Miyagi K. … Mori Y. (J. Biol. Chem. 2009) 3 23
  3. TRPC7. (PMID: 17217055) Numaga T. … Mori Y. (Handb Exp Pharmacol 2007) 3 23
  4. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. (PMID: 16382100) Clapham D.E. … Schultz G. (Pharmacol. Rev. 2005) 2 3
  5. Endogenous TRPC1, TRPC3, and TRPC7 proteins combine to form native store-operated channels in HEK-293 cells. (PMID: 15972814) Zagranichnaya T.K. … Villereal M.L. (J. Biol. Chem. 2005) 3 23

Products for TRPC7 Gene

Sources for TRPC7 Gene

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