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TRPC6 Gene

protein-coding   GIFtS: 67
GCID: GC11M101322

Transient Receptor Potential Cation Channel, Subfamily C,...

(Previous name: focal segmental glomerulosclerosis 2)
(Previous symbol: FSGS2)
  See TRPC6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Transient Receptor Potential Cation Channel, Subfamily C, Member 61 2     Transient Receptor Protein 62 3
FSGS21 2 5     TRP-62 3
TRP62 3 5     Short Transient Receptor Potential Channel 62
Focal Segmental Glomerulosclerosis 21 2     TrpC63

External Ids:    HGNC: 123381   Entrez Gene: 72252   Ensembl: ENSG000001376727   OMIM: 6036525   UniProtKB: Q9Y2103   
ORGUL members:         

Export aliases for TRPC6 gene to outside databases

Previous GC identifers: GC11M103516 GC11M102679 GC11M101356 GC11M100860 GC11M100827 GC11M097256


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRPC6 Gene:
The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is
activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger
system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of
intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2).
(provided by RefSeq, Mar 2009)

GeneCards Summary for TRPC6 Gene:
TRPC6 (transient receptor potential cation channel, subfamily C, member 6) is a protein-coding gene. Diseases associated with TRPC6 include diencephalic neoplasm, and focal segmental glomerulosclerosis 2. GO annotations related to this gene include store-operated calcium channel activity and inositol 1,4,5 trisphosphate binding. An important paralog of this gene is TRPC4.

UniProtKB/Swiss-Prot: TRPC6_HUMAN, Q9Y210
Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated
by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled
receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C.
Seems not to be activated by intracellular calcium store depletion

Gene Wiki entry for TRPC6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRPC6 gene promoter:
         AhR   ISGF-3   AML1a   ATF-2   Arnt   CRE-BP1   CREB   deltaCREB   HOXA5   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRPC6 promoter sequence
   Search Chromatin IP Primers for TRPC6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRPC6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.1   Ensembl cytogenetic band:  11q22.1   HGNC cytogenetic band: 11q22.1

TRPC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRPC6 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M101322:  view genomic region     (about GC identifiers)

Start:
101,322,295 bp from pter      End:
101,743,293 bp from pter
Size:
420,999 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRPC6_HUMAN, Q9Y210 (See protein sequence)
Recommended Name: Short transient receptor potential channel 6  
Size: 931 amino acids; 106326 Da
Subunit: Interacts with MX1 and RNF24
Secondary accessions: Q52M59 Q9HCW3 Q9NQA8 Q9NQA9
Alternative splicing: 3 isoforms:  Q9Y210-1   Q9Y210-2   Q9Y210-3   

Explore the universe of human proteins at neXtProt for TRPC6: NX_Q9Y210

Explore proteomics data for TRPC6 at MOPED

Post-translational modifications: 

  • Phosphorylated by FYN, leading to an increase of TRPC6 channel activity (By similarity)1
  • Glycosylation2 at Asn473, Asn561
  • Modification sites at PhosphoSitePlus

  • See TRPC6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004612.2  
    ENSEMBL proteins: 
     ENSP00000340913   ENSP00000435574   ENSP00000343672   ENSP00000353687  
    Reactome Protein details: Q9Y210

    TRPC6 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TRPC6

     
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    Search eBioscience for ELISAs for TRPC6 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TRP: Voltage-gated ion channels / Transient receptor potential cation channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: TRPC6
    Transient Receptor Potential channels

    Selected InterPro protein domains (see all 7):
     IPR002153 TRPC_channel
     IPR005821 Ion_trans_dom
     IPR004729 TRP_channel
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y210

    ProtoNet protein and cluster: Q9Y210

    4 Blocks protein domains:
    IPB002110 Ankyrin repeat signature
    IPB002153 Transient receptor potential family signature
    IPB005462 Transient receptor potential channel 6 signature
    IPB013555 Transient receptor ion channel II


    UniProtKB/Swiss-Prot: TRPC6_HUMAN, Q9Y210
    Similarity: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily
    Similarity: Contains 4 ANK repeats


    Find genes that share domains with TRPC6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRPC6_HUMAN, Q9Y210
    Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated
    by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled
    receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C.
    Seems not to be activated by intracellular calcium store depletion

         Genatlas biochemistry entry for TRPC6:
    transient receptor potential non voltage channel 6,Drosophila store-operated channel (SOC),predominantly expressed
    in the lung,involved in CA2+ entry stimulated by a G protein coupled receptor from extracellular space by a
    process called calcium capacitative entry (CCE)

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005261cation channel activity ----
    GO:0005262calcium channel activity ----
    GO:0005488binding ----
    GO:0005515protein binding IPI15757897
         
    Find genes that share ontologies with TRPC6           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Trpc6):
     behavior/neurological  cardiovascular system  integument  muscle  nervous system 
     vision/eye 

    Find genes that share phenotypes with TRPC6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Trpc6tm1Lbi for TRPC6

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRPC6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRPC6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRPC6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRPC6

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRPC6:
    hsa-mir-124-3p (MIRT022827)

    Block miRNA regulation of human, mouse, rat TRPC6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRPC6 (see all 15):
    hsa-miR-29c hsa-miR-29a hsa-miR-578 hsa-miR-218 hsa-miR-519e* hsa-miR-1297 hsa-miR-33a* hsa-miR-515-5p
    SwitchGear 3'UTR luciferase reporter plasmidTRPC6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRPC6
    Predesigned siRNA for gene silencing in human, mouse, rat TRPC6

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for TRPC6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRPC6 (NM_004621)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRPC6_HUMAN, Q9Y210: Membrane; Multi-pass membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton2
    endoplasmic reticulum2
    extracellular2
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0036057slit diaphragm IEA--

    Find genes that share ontologies with TRPC6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TRPC6 About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Platelet homeostasis
    Platelet homeostasis
    Platelet calcium homeostasis0.00
    Elevation of cytosolic Ca2+ levels0.00
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    5Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58


    Find genes that share SuperPaths with TRPC6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TRPC6
        Intracellular Calcium Signaling

    3 BioSystems Pathways for TRPC6
        Endothelins
    Nephrin/Neph1 signaling in the kidney podocyte
    EPO signaling pathway

    4 Reactome Pathways for TRPC6
        TRP channels
    Effects of PIP2 hydrolysis
    Role of second messengers in netrin-1 signaling
    Elevation of cytosolic Ca2+ levels


        Pathway & Disease-focused RT2 Profiler PCR Array including TRPC6: 
              Neuronal Ion Channels in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TRPC6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRPC6 (Q9Y2101, 3 ENSP000003409134) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MX1P205911, 3, ENSP000003815994EBI-929362,EBI-929476 I2D: score=3 STRING: ENSP00000381599
    FYNP062413, ENSP000003576564I2D: score=2 STRING: ENSP00000357656
    NPHS1O605003, ENSP000003681904I2D: score=1 STRING: ENSP00000368190
    NPHS2Q9NP853, ENSP000003565874I2D: score=1 STRING: ENSP00000356587
    ORAI1Q96D313, ENSP000003282164I2D: score=1 STRING: ENSP00000328216
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0006812cation transport TAS9930701
    GO:0007204positive regulation of cytosolic calcium ion concentration IEA--
    GO:0007411axon guidance TAS--
    GO:0007568aging IEA--

    Find genes that share ontologies with TRPC6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRPC6

    Selected HMDB Compounds for TRPC6 (see all 844)    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----

    Selected IUPHAR Ligands for TRPC6 (TRPC6) (see all 19)    About this table
    LigandTypeActionAffinityPubmed IDs
    La3+
    Channel blockerNone5.22--
    SKF96365
    Channel blockerNone5.22--
    20-HETE
    ActivatorNone5.22--
    ML9
    Channel blockerNone5.22--
    flufenamate
    ActivatorNone5.22--
    ACAA
    Channel blockerNone5.22--
    hyperforin
    ActivatorNone5.2217666455
    GsMTx-4
    Channel blockerNone5.22--
    arachidonic acid
    ActivatorNone5.22--
    KB-R7943
    Channel blockerNone5.22--

    10 Novoseek inferred chemical compound relationships for TRPC6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2-aminoethoxydiphenylborane 90.6 2 20068131 (1), 17351372 (1)
    skf 96365 87 1 15362854 (1)
    1-oleoyl-2-acetyl-sn-glycerol 80.8 7 15601622 (2), 15362854 (1), 17351372 (1)
    flufenamic acid 63.8 9 19232718 (4), 14551041 (1)
    thapsigargin 61.6 4 12736151 (1), 18436303 (1)
    calcium 59.9 31 16204251 (4), 18800249 (4), 17459670 (2), 18506892 (2) (see all 16)
    inositol 1,4,5 trisphosphate 45.3 4 15104177 (1), 15601622 (1), 15104179 (1)
    phosphatidylinositol 29.5 3 15362854 (1), 19129465 (1)
    phenylephrine 9.54 1 14640978 (1)
    lipid 0 2 16270640 (1)



    Find genes that share compounds with TRPC6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRPC6 gene: 
    NM_004621.5  

    Unigene Cluster for TRPC6:

    Transient receptor potential cation channel, subfamily C, member 6
    Hs.159003  [show with all ESTs]
    Unigene Representative Sequence: NM_004621
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344327(uc001pgk.4 uc009ywy.3 uc009ywz.1) ENST00000532133
    ENST00000348423 ENST00000360497 ENST00000532184 ENST00000527240 ENST00000526713

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    Selected qRT-PCR Assays for microRNAs that regulate TRPC6 (see all 15):
    hsa-miR-29c hsa-miR-29a hsa-miR-578 hsa-miR-218 hsa-miR-519e* hsa-miR-1297 hsa-miR-33a* hsa-miR-515-5p
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPC6
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRPC6
      QuantiTect SYBR Green Assays in human, mouse, rat TRPC6
      QuantiFast Probe-based Assays in human, mouse, rat TRPC6

    Additional mRNA sequence: 

    AF080394.2 AF086426.1 AJ006276.1 AJ007018.1 AJ271066.1 AJ271067.1 AJ271068.1 AK001960.1 
    AK027769.1 BC093658.1 BC093660.1 

    2 DOTS entries:

    DT.65286058  DT.91757126 

    Selected AceView cDNA sequences (see all 27):

    AF080394 AI381238 AJ271066 BM724871 BI771648 CA312768 AJ271067 AU136989 
    AJ006276 AA633029 AJ007018 BI771244 AJ271068 BX098806 AF086426 BU741499 
    NM_004621 AK001960 AK027769 AI658667 BF001360 W79774 AU156966 W79110 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TRPC6    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
    SP1:                                                                    -                 -               
    SP2:                    -     -                                         -                 -               
    SP3:                          -                                         -                                 
    SP4:                                                                                                      


    ECgene alternative splicing isoforms for TRPC6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    TRPC6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAGTGGTG
    TRPC6 Expression
    About this image


    TRPC6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Liver Bud
             Liver Lobule
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    TRPC6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRPC6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.159003

    UniProtKB/Swiss-Prot: TRPC6_HUMAN, Q9Y210
    Tissue specificity: Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in
    podocytes and is a component of the glomerular slit diaphragm

        Pathway & Disease-focused RT2 Profiler PCR Array including TRPC6: 
              Neuronal Ion Channels in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TRPC6
    OriGene qSTAR qPCR primer pairs in human, mouse for TRPC6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRPC6
    QuantiTect SYBR Green Assays in human, mouse, rat TRPC6
    QuantiFast Probe-based Assays in human, mouse, rat TRPC6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for TRPC6 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trpc61 , 5 transient receptor potential cation channel, subfamily more1, 5 88.35(n)1
    93.66(a)1
      9 (2.46 cM)5
    220681  NM_013838.21  NP_038866.21 
     85441965 
    chicken
    (Gallus gallus)
    Aves TRPC61 transient receptor potential cation channel, subfamily more 81.1(n)
    88.48(a)
      418989  XM_003640588.2  XP_003640636.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRPC66
    transient receptor potential cation channel, subfa...
    88(a)
    1 ↔ 1
    3(192700155-192785803)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia trpc61 transient receptor potential cation channel, subfamily more 77.17(n)
    85.2(a)
      100493327  XM_002935570.2  XP_002935616.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003330901 transient receptor potential cation channel, subfamily more 70.51(n)
    79.27(a)
      100333090  XM_002665399.2  XP_002665445.2 
    worm
    (Caenorhabditis elegans)
    Secernentea trp-11 , 3 Transient-receptor-potential (trp)
    protein3
    trp-11
    36(a)3
    51.81(n)1
    41.64(a)1
      III(8607645-8614376)3
    1762021  NM_001047424.21  NP_001040889.11 


    ENSEMBL Gene Tree for TRPC6 (if available)
    TreeFam Gene Tree for TRPC6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TRPC6 gene
    TRPC42  TRPC12  TRPC72  TRPC52  TRPC32  
    6 SIMAP similar genes for TRPC6 using alignment to 2 protein entries:     TRPC6_HUMAN (see all proteins):
    TRPC3    TRPC7    TRP7    TRPC5    TRPC4    TRPC1

    Find genes that share paralogs with TRPC6           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for TRPC6 (see all 11)
    PGOHUM00000242910 PGOHUM00000239435 PGOHUM00000245787 PGOHUM00000235165 PGOHUM00000235416


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for TRPC6 (see all 3439)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1214343911,2,,4
    C,FFocal segmental glomerulosclerosis 2 (FSGS2)4 pathogenic1101245345(-) GGCCAA/GTGAGC 2 N S mis11Minor allele frequency- G:0.00NA 4550
    VAR_0267344
    Focal segmental glomerulosclerosis 2 (FSGS2)4--see VAR_0267342 E K mis40--------
    VAR_0267304
    Focal segmental glomerulosclerosis 2 (FSGS2)4--see VAR_0267302 P Q mis40--------
    VAR_0267334
    Focal segmental glomerulosclerosis 2 (FSGS2)4--see VAR_0267332 R C mis40--------
    VAR_0672484
    Focal segmental glomerulosclerosis 2 (FSGS2)4--see VAR_0672482 H L mis40--------
    VAR_0267324
    Focal segmental glomerulosclerosis 2 (FSGS2)4--see VAR_0267322 S T mis40--------
    rs357139491,2
    C--97277762(+) TTATG-/AAAAAA 1 -- int12Minor allele frequency- A:0.00NA CSA 4
    rs755881381,2
    C--97286306(+) ACTTT-/AATCAG 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1995303881,2
    C--97286306(+) ACTTTA/TATCAG 1 -- int10--------
    rs1465473471,2
    C--97289391(+) TGCTA-/TGTGTGT 1 -- int10--------
    rs113250781,2
    C--97290083(+) TTTTG-/TTTTTT 1 -- int1 trp31Minor allele frequency- T:0.00NA 2
    rs341366931,2
    C--97290394(+) TTTTTA/-AATTC 1 -- int11Minor allele frequency- -:0.00NA 2
    rs359381771,2
    C--97294432(+) CAATA-/TTTTTTTT 2 -- int1 cds10--------
    rs1113679061,2
    C--97296628(+) ACATTC/TTTTTT 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs3759532861,2
    C--97296628(+) ACATT-/CTTTTT 1 -- int10--------
    rs3724906991,2
    C--97304558(+) AATGT-/TAATATA 1 -- int10--------
    rs2012411031,2
    C--97304844(+) ATATA-/TACAATAT 1 -- int10--------
    rs358638341,2
    C--97311880(+) CTCTA-/ACACACA 1 -- int10--------
    rs122774941,2
    C,F,H--97325369(+) aaagcA/Gacttt 1 -- int16Minor allele frequency- G:0.06NS EA WA NA 658
    rs105417701,2
    C--97350048(+) ATTTG-/AAAT  
            
    AAATA
    1 -- int10--------
    rs719604361,2
    C--97351776(+) TTTAG-/TTAA  
            
    TTAAT
    1 -- int10--------
    rs113668491,2
    C--97353102(+) CACCA-/GTTCTC 1 -- int10--------
    rs758846661,2
    C--97353102(+) CACCAA/G/TTTCTC 1 -- int10--------
    rs50055031,2
    C--97353514(+) TTCTGG/TTTTTT 1 -- int10--------
    rs106242491,2
    C--97353881(+) CAAAC-/ATATGTG 1 -- int10--------
    rs1393284191,2
    C--97354194(+) TAAAT-/TAAAT 
            
    AATAA
    1 -- int10--------
    rs357189971,2
    C--97357816(+) TTTTTTT/-AATTT 1 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs343284771,2
    C--97358909(+) AAAAA-/A/AA  
            
    TTAAC
    1 -- int10--------
    rs113653061,2
    C--97360830(+) AAAAAA/-TAGAG 1 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs778990381,2
    C--97362131(+) CACAC-/AA    
       
    /C/CA
    AAAAA
    1 -- int10--------
    rs1401047621,2
    C--97362668(+) CACAA-/ACAC  
            
    ACAAA
    1 -- int10--------
    rs792613561,2
    --97362671(+) AAACAA/CACAAA 1 -- int10--------
    rs1475303941,2
    C--97362779(+) CATGT-/ATAC  
            
    ATATA
    1 -- int10--------
    rs113582351,2
    C--97364071(+) TTAAC-/TTTTTT 1 -- int10--------
    rs340256151,2
    C--97370654(+) TATAT-/GGGGTA 1 -- int11Minor allele frequency- G:0.00NA 2
    rs344897921,2
    C--97371901(+) AAAAA-/A/AA  
            
    GCAGC
    1 -- int12NA CSA 4
    rs1928772751,2
    --101191926(+) AAATGA/CGTTTA 1 -- ds50010--------
    rs1852794581,2
    --101192058(+) GAACCA/GTAAGA 1 -- ds50010--------
    rs1902283411,2
    --101192100(+) AACCCA/GCAGTC 1 -- ds50010--------
    rs1820057281,2
    --101192188(+) TTTCTC/TGAGTC 1 -- ds50010--------
    rs729842061,2
    C--101192306(+) GCTGAC/TAGTGC 1 -- ds50010--------
    rs1891496441,2
    --101192368(+) AATATC/TTGAAA 1 -- ut310--------
    rs1809300161,2
    --101192407(+) TTTCCA/GTAAGT 1 -- ut310--------
    rs1178953431,2
    C,F--101192667(+) TCATCA/G/TCTTTT 2 -- ut311EA 120
    rs1166907271,2
    C--101192711(+) AGTAAC/AAACAA 1 -- ut311Minor allele frequency- A:0.01WA 118
    rs1426553351,2
    C--101192718(+) ACAACA/CACCTC 1 -- ut310--------
    rs1460337361,2
    C--101192786(+) ACATAC/TTGAAA 1 -- ut310--------
    rs1385589201,2
    C--101192796(+) AATAAC/GAGATA 1 -- ut310--------
    rs1859484811,2
    --101192923(+) ACCACA/GGTGTT 1 -- ut310--------
    rs757854151,2
    C--101193045(+) ACAAAA/CTAGGG 1 -- ut310--------
    rs2013998051,2
    C--101193052(+) AACTAA/GGGCAA 1 -- ut310--------
    rs1416518281,2
    C--101193086(+) ATTTA-/CAC   
       ACACG
    CACAC
    1 -- ut310--------
    rs616212251,2
    C--101193093(+) CACAC-/GCA   
       CACAC
    ACAAA
    1 -- ut310--------
    rs1913237751,2
    --101193180(+) AGATGA/CATCAG 1 -- ut310--------
    rs1812253771,2
    --101193186(+) ATCAGA/CAAATT 1 -- ut310--------
    rs79313991,2
    C,F,A,H--101193207(+) GTAAGA/C/TCCATT 2 -- ut31 ese322NS EA NA WA CSA 2332
    rs1129161711,2
    C--101193230(+) TATCAA/GTCATG 1 -- ut312Minor allele frequency- G:0.04CSA WA 120
    rs1493031181,2
    C--101193240(+) GTGCAC/TTGAGG 1 -- ut310--------
    rs762895271,2
    C--101193396(+) AAACTG/TCAGAG 1 -- ut310--------
    rs778693431,2
    C--101193397(+) AACTTC/GAGAGG 1 -- ut310--------
    rs1869814021,2
    --101193419(+) GGGGAA/GTAACG 1 -- ut310--------
    rs1447141631,2
    C--101193423(+) AGTAAC/TGTGGG 1 -- ut310--------
    rs1906068201,2
    C--101193542(+) CAACTA/GGGCAT 1 -- ut310--------
    rs1828945391,2
    C--101193687(+) GCACTG/TAAGAA 1 -- ut310--------
    rs2012859071,2
    C--101193720(+) CTTCAA/CGTGGA 1 -- ut310--------
    rs2007910471,2
    C--101193747(+) TCTAAA/GGAAGT 1 -- ut310--------
    rs1879702741,2
    C,F--101193751(+) AGGAAG/ATCTTC 1 -- ut311Minor allele frequency- A:0.00EU 1323
    rs1393300111,2
    C--101193786(+) ATTTGG/ATTCCA 2 /P /S mis11Minor allele frequency- A:0.00NA 4536
    rs2003265641,2
    C--101193791(+) GTTCCA/GTGGAT 2 T M mis10--------
    rs128053981,2
    C,F,H--101193844(+) GTATTC/TTGAGA 2 Q syn1 ese310Minor allele frequency- T:0.09NS EA NA EU 6393
    rs1485299341,2
    C--101193845(+) TATTCT/CGAGAT 2 /Q /R mis11Minor allele frequency- C:0.00NA 4540
    rs1997473601,2
    --101193871(+) TCATAA/GCGGAG 2 R syn10--------
    rs597433461,2
    C--101193931(+) GTGAT-/AAGAAGTC 1 -- int11Minor allele frequency- AAG:0.00NA 2
    rs2004718621,2
    --101193935(+) TAAGA-/AGTCAACT 1 -- int10--------
    rs2021123611,2
    C--101193947(+) TATAAA/GTACGC 1 -- int11Minor allele frequency- G:0.00EU 1311
    rs2011364241,2
    --101193958(+) AATGCA/GGAAAA 1 -- int10--------
    rs1454752741,2
    --101193975(+) GACTGC/TGGGAC 1 -- int10--------
    rs1159905901,2
    C,F--101193980(+) TGGGAC/TAGGAG 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1908837761,2
    --101194043(+) ATAACA/TTCCTA 1 -- int10--------
    rs128043911,2
    C,F,H--101194057(+) GAGCAG/AGTTTT 1 -- int19Minor allele frequency- A:0.06NS EA NA 528
    rs1827008261,2
    C--101194078(+) GCTAAA/GTGTTT 1 -- int10--------
    rs1383714501,2
    C--101194129(+) TCCTA-/AAGT  
            
    AAGTA
    1 -- int10--------
    rs1472439021,2
    --101194276(+) CGCCTC/GTGGAG 1 -- int10--------
    rs1877776581,2
    --101194288(+) CATAGC/TCTGTT 1 -- int10--------
    rs1927954691,2
    --101194367(+) CTGTAC/TGCATC 1 -- int10--------
    rs1407536051,2
    --101194380(+) TGCAGC/TTCTCC 1 -- int10--------
    rs1848489371,2
    C--101194407(+) GCCCCC/TGTCCT 1 -- int10--------
    rs1868581311,2
    C--101194412(+) CGTCCC/TGACTC 1 -- int10--------
    rs2017566951,2
    C--101194443(+) TTCTGC/TGTTCA 1 -- int10--------
    rs1448837461,2
    C--101194516(+) ATGAGC/TCTTTT 2 R syn10--------
    rs2007190741,2
    C--101194571(+) TCAGGG/TTCATG 1 -- int10--------
    rs1921097531,2
    C--101194581(+) GACAAA/GTCTCT 1 -- int10--------
    rs3749380421,2
    C--101194677(+) GATGCA/CGCGAT 1 -- int10--------
    rs1842404101,2
    --101194786(+) AAATCA/CTTTAT 1 -- int10--------
    rs1893907131,2
    --101194875(+) TGCTCA/GTGGAA 1 -- int10--------
    rs104443511,2
    C,F,A,H--101194920(+) CCCACG/ATCTGA 1 -- int121Minor allele frequency- A:0.34NS EA NA WA CSA 2347
    rs1823263311,2
    --101195124(+) TTTACA/GCCTAA 1 -- int10--------
    rs1513323521,2
    --101195228(+) GTTATA/GTAATA 1 -- int10--------
    rs1844731471,2
    --101195271(+) AGGAAA/TTATTT 1 -- int10--------
    rs1894511651,2
    --101195508(+) GCAGAA/CTTTGT 1 -- int10--------
    rs1405341581,2
    --101195519(+) TTCTCA/GCTGGT 1 -- int10--------
    rs1500325451,2
    C--101195530(+) GGAATC/GTGACA 1 -- int10--------
    rs113010081,2
    C--101195637(+) CTTTA-/TTTTTT 1 -- int12Minor allele frequency- T:0.00NA CSA 4
    rs71211241,2
    C,F,A--101195652(+) CTTATA/TTATCT 1 -- int18Minor allele frequency- T:0.48NA CSA WA 248
    rs1996876261,2
    C--101195813(+) AAAATC/TCATGC 1 -- int11Minor allele frequency- T:0.00EU 1285
    rs618908531,2
    C--101195847(+) TTATTA/G/TAAACT 3 L F mis1 syn10--------
    rs729842091,2
    C,F--101195862(+) AGATGG/AAAATC 2 /F syn16Minor allele frequency- A:0.15CSA WA NA EU 6056
    rs2017747751,2
    C--101195922(+) AAAAGA/GTTTAG 1 -- int10--------
    rs1453690541,2
    --101195976(+) ATTAGA/TTATCT 1 -- int10--------
    rs1402876761,2
    --101195997(+) TAGTCC/TTACAT 1 -- int10--------
    rs1814427221,2
    --101196041(+) CTTGCA/C/TTAGTA 1 -- int10--------
    rs71050831,2
    C,F,A--101196044(+) GCTTAG/ATATTC 1 -- int110Minor allele frequency- A:0.35NA WA CSA EA 370
    rs1453889251,2
    --101196050(+) TATTCC/TGTCTT 1 -- int10--------
    rs79280281,2
    C,F,A,H--101196193(+) CAGATG/AAATGC 1 -- int110Minor allele frequency- A:0.34NA WA CSA EA 370
    rs1866075011,2
    --101196354(+) ACTGTC/GGTGGA 1 -- int10--------
    rs44052761,2
    C,F,A,H--101196400(+) TTTGAA/GTTTTA 1 -- int113Minor allele frequency- G:0.32NS EA NA WA CSA 784
    rs413023731,2
    C,F--101196471(+) AGGCAA/GATAAC 1 -- int10--------
    rs1901241471,2
    --101196505(+) AAAGCA/GTACCT 1 -- int10--------
    rs1143288781,2
    C--101196683(+) CAAAAG/TGTAAG 1 -- int10--------
    rs796225901,2
    C,F--101196715(+) ATAAAT/GGAACA 1 -- int12Minor allele frequency- G:0.07WA NA 238
    rs2019544181,2
    C--101196866(+) ACTCA-/CTCTAAA 1 -- int10--------
    rs1413797411,2
    --101196933(+) ATTACA/GTAATT 1 -- int10--------
    rs1450281321,2
    --101196967(+) GTTTA-/GGGTTC 1 -- int10--------
    rs750538191,2
    C,F--101196979(+) CAAAAC/TGAGCA 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1503441231,2
    C--101197098(+) GTGGTC/TTACCT 1 -- int10--------
    rs1380578351,2
    --101197148(+) GAAATA/GCATAA 1 -- int10--------
    rs1816378971,2
    --101197309(+) AACCAA/TCATGT 1 -- int10--------
    rs1860266731,2
    C--101197427(+) CCTGGC/TCTCTA 1 -- int10--------
    rs71101621,2
    C,F,A,H--101197590(+) AAATAT/GAAACT 1 -- int121Minor allele frequency- G:0.34NS EA NA WA CSA 2330
    rs74802721,2
    H--101197701(+) CAGTTT/ACTAAT 1 -- int14Minor allele frequency- A:0.00NS EA 412
    rs1439071991,2
    --101197710(+) ATACAC/TCATAG 1 -- int10--------
    rs1911369151,2
    --101197794(+) ATTATA/TACCAC 1 -- int10--------
    rs44897131,2
    C,F,A--101197876(+) CAACAC/TGTTTG 1 -- int19Minor allele frequency- T:0.33NA WA CSA EA 369
    rs1840327231,2
    --101197932(+) TTAGGG/TATTTG 1 -- int10--------
    rs1877324471,2
    C--101198105(+) CCTTCC/TACCAC 1 -- int10--------
    rs45221351,2
    C,F,A,H--101198131(+) TATTCA/GTTTTC 1 -- int19Minor allele frequency- G:0.33NA WA CSA EA 372
    rs1472746091,2
    --101198236(+) AATTCA/GTTAAA 1 -- int10--------
    rs1910659341,2
    --101198244(+) AAAAAA/GAACAA 1 -- int10--------
    rs1164644001,2
    C,F--101198421(+) GCTGTG/ATTATA 1 -- int11Minor allele frequency- A:0.02WA 118
    rs65908601,2
    C,F,A--101198580(+) TACCTT/CCCAGA 1 -- int110Minor allele frequency- C:0.33NA WA CSA EA 375
    rs71260901,2
    C,F,H--101198725(+) GTTAAC/GTTTAA 1 -- int18Minor allele frequency- G:0.01NS EA NA WA 538
    rs1430190321,2
    --101198765(+) GTTACA/GTCATG 1 -- int10--------
    rs1446982381,2
    --101198849(+) GACCTG/TAACCA 1 -- int10--------
    rs112247681,2
    C,F,A,H--101198986(+) ACATAT/GTGCTT 1 -- int112Minor allele frequency- G:0.19NS EA NA WA CSA 665
    rs1823550811,2
    --101199075(+) AGATAA/TTTTGC 1 -- int10--------
    rs1870918101,2
    --101199154(+) ATTCAC/TGCATT 1 -- int10--------
    rs1485809681,2
    C--101199208(+) AAAAAC/TCTGCC 1 -- int10--------
    rs79500481,2
    C,F,A--101199249(+) AGAAGG/TTGGAA 1 -- int18Minor allele frequency- T:0.46NA WA CSA 249
    rs1915406351,2
    --101199251(+) AAGGTC/GGAACA 1 -- int10--------
    rs1844623461,2
    --101199266(+) AGTTAA/TTCAAG 1 -- int10--------
    rs1872975811,2
    --101199272(+) TCAAGA/CAGTTA 1 -- int10--------
    rs1931516511,2
    --101199477(+) ACCAGG/TCAGTG 1 -- int10--------
    rs1481606821,2
    C--101199479(+) CAGTC-/AGTGA 
     CCTTTAG
    AGTTA
    1 -- int10--------
    rs1856570971,2
    --101199492(+) TTAGAC/GTTAAA 1 -- int10--------
    rs1173102831,2
    F--101199632(+) AAATAC/TTTTAA 1 -- int11Minor allele frequency- T:0.01EA 120
    rs1902361761,2
    --101199637(+) CTTTAA/CAATTC 1 -- int10--------
    rs1510875601,2
    --101199675(+) GAATCA/CGAAAT 1 -- int10--------
    rs65908611,2
    C,F,A,H--101199784(+) GCATAC/TACTAG 1 -- int19Minor allele frequency- T:0.33NA WA CSA EA 369
    rs1401350221,2
    --101199884(+) ATGTCA/C/GTAAAA 1 -- int10--------
    rs122894471,2
    C,F,H--101199951(+) GAAAAG/TAGATA 1 -- int1 trp312Minor allele frequency- T:0.05NS EA WA NA 1886
    rs1440181781,2
    C--101200023(+) ACCCAA/GGATTA 1 -- int10--------
    rs118267621,2
    C,F,A,H--101200058(+) GGAACG/AGGAGA 1 -- int19Minor allele frequency- A:0.18NS EA NA CSA WA 656
    rs1464598271,2
    C--101200068(+) AAGGCA/GGAGAA 1 -- int10--------
    rs1148448281,2
    F--101200154(+) CCCAAC/GAGGGA 1 -- int11Minor allele frequency- G:0.02WA 118
    rs118222371,2
    C,F,A,H--101200164(+) AACGGC/TACATC 1 -- int119Minor allele frequency- T:0.16NS EA NA CSA WA 2310
    rs1407636331,2
    C--101200176(+) CTGTAA/GCTGCC 1 -- int10--------
    rs1120849981,2
    C,F--101200179(+) TAGCTG/ACCAGA 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1171757251,2
    C,F--101200181(+) GCTGCC/TAGAAG 1 -- int11Minor allele frequency- T:0.07EA 120
    rs1500836661,2
    --101200521(+) GTCCAA/GTGACT 1 -- int10--------
    rs1836531131,2
    --101200532(+) TATTAC/TACATC 1 -- int10--------
    rs1887997591,2
    --101200666(+) ATAATA/GTGAGT 1 -- int10--------
    rs360878101,2
    C,F--101200854(+) ATCTTC/TTGAGT 1 -- int14Minor allele frequency- T:0.03NA 126
    rs1811787061,2
    --101200867(+) TTAGTC/TCAATA 1 -- int10--------
    rs1862728781,2
    --101200870(+) GTTCAA/GTACTG 1 -- int10--------
    rs43962561,2
    C,F,A,H--101200881(+) TTACTA/CTATCA 1 -- int131Minor allele frequency- N:0.00NS EA NA WA CSA 3036
    rs112247691,2
    C,F,A,H--101201002(+) GTCAAC/TTGTAT 1 -- int118Minor allele frequency- T:0.30NS EA NA WA CSA 1207
    rs1157098041,2
    F--101201012(+) TATTAT/GATGAA 1 -- int11Minor allele frequency- G:0.03WA 118
    rs1901980531,2
    --101201014(+) TTATAG/TGAAGT 1 -- int10--------
    rs1454755871,2
    --101201025(+) CAGTAC/TATGTA 1 -- int10--------
    rs1815015161,2
    --101201133(+) TTCCAG/TATAAC 1 -- int10--------
    rs1448607281,2
    C--101201137(+) ATATA-/ACTT  
            
    ACTTA
    1 -- int10--------
    rs1874048781,2
    --101201195(+) TGCTCA/GATATA 1 -- int10--------
    rs729842281,2
    C,F--101201206(+) ATTTTA/GTGTAA 1 -- int11Minor allele frequency- G:0.03NA 120
    rs1489015121,2
    --101201534(+) ATGCTC/TCTGAA 1 -- int10--------
    rs769017331,2
    C--101201605(+) AAAATA/TAATAT 1 -- int10--------
    rs1918723141,2
    --101201684(+) GGACAC/TTGTTA 1 -- int10--------
    rs776124691,2
    C,F--101201696(+) TCTTGG/AGACTA 1 -- int11Minor allele frequency- A:0.50WA 2
    rs792916451,2
    C--101201700(+) GAGACC/TAATAA 1 -- int10--------
    rs1380709691,2
    C--101201724(+) ATCCGC/TAAGAA 1 -- int10--------
    rs754957631,2
    C,F--101201786(+) GAAATG/TTCACC 1 -- int11Minor allele frequency- T:0.02WA 118
    rs1436303011,2
    --101201994(+) CACCTG/TACTCC 1 -- int10--------
    rs1850246261,2
    --101202029(+) ATAATG/TTACTT 1 -- int10--------
    rs1472354011,2
    C--101202080(+) TAAAA-/TTGT  
            
    TTGTT
    1 -- int10--------
    rs1902206901,2
    --101202109(+) TGATGC/TCTGTA 1 -- int10--------
    rs1825223471,2
    --101202236(+) GCCAGA/GCGTGG 1 -- int10--------
    rs1464920101,2
    C--101202237(+) CCAGGA/CGTGGT 1 -- int10--------
    rs1875182741,2
    --101202304(+) CCTGGA/GAGGTC 1 -- int10--------
    rs1391257561,2
    --101202324(+) GCAAGC/GCATGA 1 -- int10--------
    rs1414851651,2
    C--101202353(+) GCCTGC/GGTGAT 1 -- int10--------
    rs1508245281,2
    --101202408(+) TTTGAA/GTTGAA 1 -- int10--------
    rs1392749851,2
    --101202630(+) CTTCCC/TGGTCT 1 -- int10--------
    rs574843691,2
    C,F--101202680(+) CAAGGA/GAGAGG 1 -- int11Minor allele frequency- G:0.04WA 118
    rs1496300391,2
    C--101202835(+) TTTCTA/GCGTAT 1 -- int10--------
    rs357619741,2
    C--101203006(+) TGTTTT/-GGTTA 1 -- int11Minor allele frequency- -:0.00NA 2
    rs1931671491,2
    --101203038(+) GTTTGA/GAGTCA 1 -- int10--------
    rs1832459091,2
    --101203110(+) CTTGGC/TTCCCT 1 -- int10--------
    rs108951101,2
    C,F,A--101203171(+) CTTGAC/TGAGGA 1 -- int15Minor allele frequency- T:0.31NA CSA 127
    rs1443935161,2
    --101203186(+) ATTGAA/GTCTGT 1 -- int10--------
    rs1396641651,2
    C--101203265(+) TTCCA-/TTTG  
            
    TTTAA
    1 -- int10--------
    rs1891064151,2
    --101203276(+) TAAGTC/TGTCTC 1 -- int10--------
    rs107914731,2
    C,F,A--101203335(+) CATCCC/TTTGTA 1 -- int12Minor allele frequency- T:0.50NA 4
    rs1930647761,2
    --101203351(+) CATTCC/TTAGGT 1 -- int10--------
    rs1438129651,2
    --101203417(+) TGTCTG/TTTATG 1 -- int10--------
    rs108951121,2
    C,F,A--101203476(+) GACTTC/TGCTGA 1 -- int12Minor allele frequency- T:0.50NA 4
    rs1838881501,2
    C--101203525(+) TGATGA/GGGCTT 1 -- int10--------
    rs108951131,2
    C,A--101203603(+) CCTTTA/CTTTCT 1 -- int1 trp31Minor allele frequency- C:0.00NA 2
    rs1421380121,2
    C--101203629(+) CCCCTG/TGCCAG 1 -- int10--------
    rs1882649931,2
    --101203645(+) CCAATA/TCTACG 1 -- int10--------
    rs112247701,2
    C,F,A--101203669(+) GTGAGG/AGAGGA 1 -- int13Minor allele frequency- A:0.31NA 124
    rs112247711,2
    C,A--101203725(+) TGCCCA/GTTCAG 1 -- int10--------
    rs1919116341,2
    --101203770(+) CTTATG/TATTTT 1 -- int10--------
    rs1842039251,2
    --101203813(+) GAGTTC/TTTAGC 1 -- int10--------
    rs108951141,2
    C,F,A,H--101203834(+) ATTGAG/ATTTTG 1 -- int14Minor allele frequency- A:0.29NS EA 420
    rs1893840901,2
    --101203921(+) TTATCA/GATTTG 1 -- int10--------
    rs1820659471,2
    --101203964(+) GAAGCC/TGGCTT 1 -- int10--------
    rs1866029801,2
    --101203987(+) TAAGCC/TTTTTG 1 -- int10--------
    rs107914741,2
    C,A,H--101204072(+) GAAATG/TTTCTT 1 -- int1 trp31Minor allele frequency- T:0.00NA 2
    rs107914751,2
    C,F,A,H--101204087(+) TGTTGC/TGTCTC 1 -- int15Minor allele frequency- T:0.33NA WA EA 362
    rs1476465711,2
    --101204089(+) TTGCGC/TCTCTG 1 -- int10--------
    rs1423088321,2
    --101204114(+) CAGGAC/TGATGC 1 -- int10--------
    rs1459234851,2
    C--101204145(+) GGGAGC/GATTCC 1 -- int10--------
    rs1907738291,2
    --101204223(+) AATCTA/GGCTAT 1 -- int10--------
    rs1818160361,2
    --101204233(+) TGAATC/TTATCT 1 -- int10--------
    rs71208571,2
    C,F,A,H--101204264(+) tggtaC/Ggctat 1 -- int13Minor allele frequency- G:0.29NA 124
    rs1852612321,2
    --101204270(+) GCTATG/TATTAC 1 -- int10--------
    rs1896871021,2
    --101204347(+) GAGGGC/TGTATG 1 -- int10--------
    rs1820776601,2
    --101204348(+) AGGGTA/GTATGT 1 -- int10--------
    rs71097341,2
    C,F,A,H--101204528(+) gctagC/Tggtct 1 -- int12Minor allele frequency- T:0.50NA 4
    rs1854918171,2
    --101204575(+) TCACTA/GATTTT 1 -- int10--------
    rs1910770211,2
    --101204741(+) TTGTGA/GGCATT 1 -- int10--------
    rs65908621,2
    C,F,A,H--101204786(+) aatgtT/Gtccca 1 -- int111Minor allele frequency- G:0.35NS EA NA WA 786
    rs1837948711,2
    --101204800(+) ATTCTA/GGTACC 1 -- int10--------
    rs1489533461,2
    --101204846(+) TTTATG/TTCTGC 1 -- int10--------
    rs1882794941,2
    --101205003(+) GAGGAA/GTGTTT 1 -- int10--------
    rs79426651,2
    C,F,A--101205056(+) gtgctG/Aagaag 1 -- int12Minor allele frequency- A:0.50NA 4
    rs1480745701,2
    C--101205332(+) TGATCC/TCTTTA 1 -- int10--------
    rs1932981261,2
    --101205345(+) ATTATG/TTAATG 1 -- int10--------
    rs1833302921,2
    --101205416(+) CAACAA/CCTGCT 1 -- int10--------
    rs1418518051,2
    C--101205459(+) TATTCC/TTCCAT 1 -- int10--------
    rs1461431131,2
    --101205472(+) CTTTAC/TTTTGA 1 -- int10--------
    rs1877176141,2
    --101205692(+) AGTGTC/TGATGG 1 -- int10--------
    rs1914392051,2
    --101205728(+) AGCAGC/TTTGTA 1 -- int10--------
    rs1836821221,2
    --101205735(+) TGTACC/TGGTTT 1 -- int10--------
    rs1390067691,2
    --101205792(+) GCCTGC/GTGGTG 1 -- int10--------
    rs1883265521,2
    --101205896(+) TATTTC/TCTTTA 1 -- int10--------
    rs1926578471,2
    --101206035(+) TCCTTC/TATTTC 1 -- int10--------
    rs79367681,2
    C,F,A--101206111(+) gtcttC/Tgtatt 1 -- int12Minor allele frequency- T:0.50NA 4
    rs1998072251,2
    C--101206144(+) GTCTTA/CCTGGG 1 -- int10--------
    rs79476951,2
    C,F,A,H--101206145(+) tcttaC/Ttgggt 1 -- int17Minor allele frequency- T:0.29NS EA NA 508
    rs1854018181,2
    --101206157(+) GGGGAA/GTTTCT 1 -- int10--------
    rs1899786351,2
    --101206181(+) CTGAAA/GAGTGT 1 -- int10--------
    rs1820176281,2
    --101206212(+) TCCCCA/GTCACC 1 -- int10--------
    rs1847474331,2
    --101206230(+) ACACTA/TATCTA 1 -- int10--------
    rs1891560791,2
    --101206334(+) TATTTC/GAGTAA 1 -- int10--------
    rs1140693811,2
    F--101206617(+) TTCTCC/TGTCTG 1 -- int11Minor allele frequency- T:0.07WA 118
    rs127957281,2
    C,F--101206618(+) tctccG/Atctgg 1 -- int15Minor allele frequency- A:0.09NA EA 246
    rs127976901,2
    C,F,A--101206759(+) cctttG/Cgtctt 1 -- int15Minor allele frequency- C:0.25NA CSA 8
    rs79304221,2
    C,F,A,H--101207053(+) agatcC/Tgctgc 1 -- int113Minor allele frequency- T:0.31NS EA NA CSA WA 764
    rs1809330801,2
    --101207174(+) CCCTGA/GCTGGG 1 -- int10--------
    rs1858823281,2
    --101207552(+) CCACTA/GGGGTA 1 -- int10--------
    rs1915232901,2
    --101207664(+) TAGGCA/TCCAGA 1 -- int10--------
    rs347921911,2
    C--101207780(+) AGAAAA/-TTCCC 1 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs1496813451,2
    --101207799(+) CCTTGC/TGATGC 1 -- int10--------
    rs1812579561,2
    --101207823(+) AGCTCA/GCCTTC 1 -- int10--------
    rs571530091,2
    C--101207874(+) AACTGC/GGTACC 1 -- int10--------
    rs128045951,2
    C,F--101207906(+) ACCTGA/C/GCTTCT 1 -- int14NA WA CSA 8
    rs1871273681,2
    --101207946(+) GAGCTC/GTTCCT 1 -- int10--------
    rs1906704951,2
    --101208025(+) TTTTTC/TCTAGA 1 -- int10--------
    rs1828608401,2
    --101208031(+) CTAGAC/TATGCC 1 -- int10--------
    rs1879809691,2
    --101208149(+) AATTAC/TGTAGT 1 -- int10--------
    rs757948911,2
    C,F--101208210(+) TATTAC/TATACC 1 -- int11Minor allele frequency- T:0.05EA 120
    rs1425033791,2
    C--101208336(+) CTTAAC/TGAGAC 1 -- int10--------
    rs1908939171,2
    --101208346(+) CAACAC/TTTTAA 1 -- int10--------
    rs1824215661,2
    --101208385(+) TGGCAA/GAAATT 1 -- int10--------
    rs41312661,2
    H--101208442(-) GTTATC/TATGAA 1 -- int11Minor allele frequency- T:0.00NS 120
    rs112247721,2
    C,F,H--101208647(+) GCTATG/AGCTTG 1 -- int120Minor allele frequency- A:0.08NS EA NA 2340
    rs752268201,2
    C,F--101208682(+) AACCAC/TTGAAC 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1422734501,2
    --101208694(+) ATCCTG/TTCTAG 1 -- int10--------
    rs1930081261,2
    C--101208821(+) CTTGTC/GTGAAC 1 -- int10--------
    rs1847135551,2
    --101208887(+) AGGGAC/TGATTT 1 -- int10--------
    rs1445624541,2
    C--101208927(+) GCCCAC/TGCGGC 1 -- int10--------
    rs1170135291,2
    C,F--101208999(+) CCACTG/ACAGCC 1 -- int11Minor allele frequency- A:0.03NA 120
    rs1881107581,2
    --101209086(+) GGGTTC/GCCCTT 1 -- int10--------
    rs1478135131,2
    C--101209253(+) AAAATA/GGTCTC 1 -- int10--------
    rs1403011301,2
    --101209290(+) ATAGCC/TATATA 1 -- int10--------
    rs1921160811,2
    --101209307(+) TTCTGA/GTCAAT 1 -- int10--------
    rs1842470861,2
    --101209393(+) CTTTGA/CCCTTA 1 -- int10--------
    rs1504219741,2
    --101209406(+) CCTACA/GTGCCT 1 -- int10--------
    rs1893971041,2
    --101209425(+) GGTATA/CATAGC 1 -- int10--------
    rs1818012861,2
    --101209426(+) GTATAA/GTAGCT 1 -- int10--------
    rs79409551,2
    C,F,H--101209617(+) TGCAGG/ATCTTA 1 -- int14Minor allele frequency- A:0.00NS EA 418
    rs170935871,2
    C,F,H--101209846(+) TCCATC/TGCTTC 1 -- int119Minor allele frequency- T:0.04NA NS EA CSA WA 2046
    rs1846600061,2
    --101209932(+) ATACCC/TTCCAT 1 -- int10--------
    rs1891266971,2
    --101209960(+) ATTCCC/TTTCTT 1 -- int10--------
    rs128005301,2
    H--101210031(+) AAATGT/GACATG 1 -- int14Minor allele frequency- G:0.00NS EA 416
    rs1491737151,2
    --101210036(+) TACATA/GCTATT 1 -- int10--------
    rs112247731,2
    C,F,A,H--101210081(+) TCTCAA/GTAACA 1 -- int122Minor allele frequency- G:0.08NS EA NA 2602
    rs1807054961,2
    --101210099(+) TGAGAA/TTTGTT 1 -- int10--------
    rs1863541171,2
    --101210122(+) TTATTA/TAATGG 1 -- int10--------
    rs1998571721,2
    --101210210(+) ACTTCA/GTATTT 1 -- int10--------
    rs617326061,2
    F--101210263(+) AAAGGT/GCTTCA 2 /D /A mis11Minor allele frequency- G:0.29NS 56
    rs1449642011,2
    C--101210326(+) TAGTAA/GAATGA 1 -- int10--------
    rs1901328381,2
    --101210388(+) TCGTCG/TAATTC 1 -- int10--------
    rs790178211,2
    F--101210450(+) CAAGTA/GCTTGC 1 -- int10--------
    rs1422364371,2
    --101210457(+) TTGCTC/TAGACA 1 -- int10--------
    rs1463953831,2
    --101210517(+) TAAACA/CACCCA 1 -- int10--------
    rs1816503911,2
    --101210661(+) TAAAGA/GAAGCT 1 -- int10--------
    rs1860347771,2
    --101210679(+) TCTCAA/GAGTAC 1 -- int10--------
    rs1481270121,2
    --101210725(+) AGATAC/TAATTT 1 -- int10--------
    rs1911496041,2
    --101210775(+) ATGTGC/GTACTT 1 -- int10--------
    rs1838678541,2
    --101211035(+) TAAAAA/GTTTGC 1 -- int10--------
    rs1880343691,2
    --101211049(+) TATATC/TGAATT 1 -- int10--------
    rs796067841,2
    C,F--101211252(+)