Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TRPC6 Gene

protein-coding GIFtS: 64
GCID: GC11M101322

transient receptor potential cation channel, subfamily C,...

Explore 32 diseases affiliated with
TRPC6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transient Receptor Potential Cation Channel, Subfamily C, Member 6¹ ²		FSGS2² ⁵
TRP6¹ ² ³ ⁵		Short Transient Receptor Potential Channel 6²
Transient Receptor Protein 6² ³		TrpC6³
TRP-6² ³

External Ids:	HGNC: 12338¹	Entrez Gene: 7225²	Ensembl: ENSG00000137672⁷	OMIM: 603652⁵	UniProtKB: Q9Y210³

Export aliases for TRPC6 gene to outside databases

Previous GC identifers: GC11M103516 GC11M102679 GC11M101356 GC11M100860 GC11M100827 GC11M097256

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRPC6:

The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is

activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system.

Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of

intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). (provided by

RefSeq, Mar 2009)

UniProtKB/Swiss-Prot: TRPC6_HUMAN, Q9Y210

Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a

phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors.

Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be

activated by intracellular calcium store depletion

Gene Wiki entry for TRPC6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_033899.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TRPC6 gene promoter:
AhR ISGF-3 AML1a ATF-2 Arnt CRE-BP1 CREB deltaCREB HOXA5 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRPC6 promoter sequence

Search SABiosciences Chromatin IP Primers for TRPC6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRPC6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.1 Ensembl cytogenetic band: 11q22.1 HGNC cytogenetic band: 11q22.1

TRPC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRPC6 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M101322: view genomic region (about GC identifiers)

Start:	101,322,295 bp from pter	End:	101,743,293 bp from pter
Size:	420,999 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TRPC6_HUMAN, Q9Y210 (See protein sequence)

Recommended Name: Short transient receptor potential channel 6

Size: 931 amino acids; 106326 Da

Subunit: Interacts with MX1 and RNF24

Subcellular location: Membrane; Multi-pass membrane protein (Probable)

Secondary accessions: Q52M59 Q9HCW3 Q9NQA8 Q9NQA9

Alternative splicing: 3 isoforms: Q9Y210-1 Q9Y210-2 Q9Y210-3

Explore the universe of human proteins at neXtProt for TRPC6: NX_Q9Y210

Post-translational modifications:

Phosphorylated by FYN, leading to an increase of TRPC6 channel activity (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y210

TRPC6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004612.2

ENSEMBL proteins:

ENSP00000340913 ENSP00000435574 ENSP00000343672 ENSP00000353687

Reactome Protein details: Q9Y210
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for TRPC6
	GenScript Custom Purified and Recombinant Proteins Services for TRPC6
	Novus Biologicals TRPC6 Proteins
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TRPC6

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	IEA	--
GO:0036057	slit diaphragm	IEA	--

TRPC6 for ontologies About GeneDecksing

TRPC6 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of TRPC6
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 3): TRPC6 OriGene Custom Antibody Services for TRPC6
	GenScript Custom Superior Antibodies Services for TRPC6
	Novus Biologicals TRPC6 Antibodies
	Abcam antibodies for TRPC6
	Uscn Antibodies for TRPC6
	ThermoFisher Antibodies for TRPC6

Assay Products for TRPC6:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TRPC6
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TRPC6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TRPC6 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR002153 TRPC_channel

IPR020683 Ankyrin_rpt-contain_dom

IPR005821 Ion_trans_dom

IPR004729 TRP_channel

IPR002110 Ankyrin_rpt

Graphical View of Domain Structure for InterPro Entry Q9Y210

ProtoNet protein and cluster: Q9Y210

4 Blocks protein families:

IPB002110 Ankyrin repeat signature

IPB002153 Transient receptor potential family signature

IPB005462 Transient receptor potential channel 6 signature

IPB013555 Transient receptor ion channel II

UniProtKB/Swiss-Prot: TRPC6_HUMAN, Q9Y210

Similarity: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily

Similarity: Contains 4 ANK repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TRPC6_HUMAN, Q9Y210

Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a

phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors.

Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be

activated by intracellular calcium store depletion

Genatlas biochemistry entry for TRPC6:

transient receptor potential non voltage channel 6,Drosophila store-operated channel (SOC),predominantly expressed in

the lung,involved in CA2+ entry stimulated by a G protein coupled receptor from extracellular space by a process

called calcium capacitative entry (CCE)

miRNA Products:		OriGene 3'-UTR Clone: TRPC6 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRPC6
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate TRPC6 (see all 15):
		hsa-miR-29c hsa-miR-29a hsa-miR-578 hsa-miR-218 hsa-miR-519e* hsa-miR-1297 hsa-miR-33a* hsa-miR-515-5p

		SwitchGear 3'UTR luciferase reporter plasmid: TRPC6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRPC6 (see all 6) OriGene siRNA: TRPC6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRPC6

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TRPC6

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRPC6 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRPC6 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TRPC6 (NM_004621)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRPC6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPC6

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TRPC6
		Search LifeMap BioReagents cell lines for TRPC6

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC6

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005216	ion channel activity	--	--
GO:0005261	cation channel activity	--	--
GO:0005262	calcium channel activity	--	--
GO:0005515	protein binding	IPI	15757897
GO:0015279	store-operated calcium channel activity	IEA	--

TRPC6 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Trpc6^tm1Lbi for TRPC6
     6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Trpc6):

behavior/neurological	cardiovascular system	integument	muscle	nervous system
vision/eye

TRPC6 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Platelet activation, signaling and aggregation

Platelet activation, signaling and aggregation

1.00

Hemostasis

0.43

Role of second messengers in netrin-1 signaling

Role of second messengers in netrin-1 signaling

1.00

Activation of TRPC channels by Netrin-1

0.60

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Platelet calcium homeostasis

Platelet calcium homeostasis

1.00

Elevation of cytosolic Ca2+ levels

0.47

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for TRPC6

	Sodium channels and transporters- inward current
	Calcium channels

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TRPC6

Intracellular Calcium Signaling

3 BioSystems Pathways for TRPC6

	Endothelins
	EPO signaling pathway
	Nephrin/Neph1 signaling in the kidney podocyte

5/16 Reactome Pathways for TRPC6 (see all 16)

	Developmental Biology
	Platelet homeostasis
	Elevation of cytosolic Ca2+ levels
	Signal Transduction
	G alpha (q) signalling events

TRPC6 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TRPC6

STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

5/21 Interacting proteins for TRPC6 (Q9Y210^{1, 3} ENSP00000340913⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MX1	P20591¹^,³, ENSP00000381599⁴	EBI-929362,EBI-929476 I2D: score=3 STRING: ENSP00000381599
FYN	P06241³, ENSP00000357656⁴	I2D: score=2 STRING: ENSP00000357656
NPHS1	O60500³, ENSP00000368190⁴	I2D: score=1 STRING: ENSP00000368190
NPHS2	Q9NP85³, ENSP00000356587⁴	I2D: score=1 STRING: ENSP00000356587
ORAI1	Q96D31³, ENSP00000328216⁴	I2D: score=1 STRING: ENSP00000328216

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006812	cation transport	TAS	9930701
GO:0007204	elevation of cytosolic calcium ion concentration	IEA	--
GO:0007411	axon guidance	TAS	--
GO:0007596	blood coagulation	TAS	--
GO:0030168	platelet activation	TAS	--

TRPC6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TRPC6 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TRPC6

10/844 HMDB Compounds for TRPC6 (see all 844) About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
DG(14:0/14:0/0:0)	DAG(14:0/14:0) (see all 9)	--	--
DG(14:0/14:1(9Z)/0:0)	DAG(14:0/14:1) (see all 15)	--	--
DG(14:0/15:0/0:0)	Diacylglycerol(29:0) (see all 9)	--	--
DG(14:0/16:0/0:0)	DAG(30:0) (see all 9)	--	--
DG(14:0/16:1(9Z)/0:0)	DG(30:1) (see all 15)	--	--
DG(14:0/18:0/0:0)	DG(14:0/18:0) (see all 9)	--	--
DG(14:0/18:1(11Z)/0:0)	Diacylglycerol (see all 15)	--	--
DG(14:0/18:1(9Z)/0:0)	1-myristoyl-2-oleoyl-sn-glycerol (see all 15)	--	--
DG(14:0/18:2(9Z,12Z)/0:0)	DAG(14:0/18:2n6) (see all 15)	--	--

10 Novoseek chemical compound relationships for TRPC6 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
2-aminoethoxydiphenylborane	90.6	2	20068131 (1), 17351372 (1)
skf 96365	87	1	15362854 (1)
1-oleoyl-2-acetyl-sn-glycerol	80.8	7	15601622 (2), 15362854 (1), 17351372 (1)
flufenamic acid	63.8	9	19232718 (4), 14551041 (1)
thapsigargin	61.6	4	12736151 (1), 18436303 (1)
calcium	59.9	31	16204251 (4), 18800249 (4), 17459670 (2), 18506892 (2) (see all 16)
inositol 1,4,5 trisphosphate	45.3	4	15104177 (1), 15601622 (1), 15104179 (1)
phosphatidylinositol	29.5	3	15362854 (1), 19129465 (1)
phenylephrine	9.54	1	14640978 (1)
lipid	0	2	16270640 (1)

Search CenterWatch for drugs/clinical trials and news about TRPC6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TRPC6 gene:

NM_004621.5

Unigene Cluster for TRPC6:

Transient receptor potential cation channel, subfamily C, member 6

Hs.159003 [show with all ESTs]

Unigene Representative Sequence: NM_004621

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000344327(uc001pgk.4 uc009ywy.3 uc009ywz.1) ENST00000532133

ENST00000348423 ENST00000360497 ENST00000532184 ENST00000527240 ENST00000526713

miRNA Products:		OriGene 3'-UTR Clone: TRPC6 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRPC6
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate TRPC6 (see all 15):
		hsa-miR-29c hsa-miR-29a hsa-miR-578 hsa-miR-218 hsa-miR-519e* hsa-miR-1297 hsa-miR-33a* hsa-miR-515-5p

		SwitchGear 3'UTR luciferase reporter plasmid: TRPC6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRPC6 (see all 6) OriGene siRNA: TRPC6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRPC6

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRPC6 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRPC6 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TRPC6 (NM_004621)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRPC6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPC6

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRPC6 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TRPC6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRPC6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRPC6

Additional cDNA sequence:

AF080394.2 AF086426.1 AJ006276.1 AJ007018.1 AJ271066.1 AJ271067.1 AJ271068.1 AK001960.1

AK027769.1 BC093658.1 BC093660.1

2 DOTS entries:

DT.65286058 DT.91757126

24/27 AceView cDNA sequences (see all 27):

AF080394 BM724871 BI771648 AI381238 AJ271066 AK001960 AJ006276 AI658667

BU741499 AU136989 AK027769 BI771244 AJ271068 AF086426 AA633029 AJ271067

BX098806 NM_004621 AJ007018 CA312768 BF106229 W79774 AU156966 W79110

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for TRPC6 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12a	·	12b	^	13a	·	13b
SP1:																							-						-
SP2:							-		-														-						-
SP3:									-														-
SP4:

ECgene alternative splicing isoforms for TRPC6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRPC6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAAGTGGTG

About this image

TRPC6 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Visceral White Adipose

Adipose

Liver

Liver Lobule

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TRPC6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRPC6

SOURCE GeneReport for Unigene cluster: Hs.159003

UniProtKB/Swiss-Prot: TRPC6_HUMAN, Q9Y210

Tissue specificity: Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes

and is a component of the glomerular slit diaphragm

SABiosciences Expression via Pathway-Focused PCR Array including TRPC6:

Neuronal Ion Channels in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRPC6 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TRPC6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRPC6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRPC6

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TRPC6 gene from 5/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TRPC6¹	transient receptor potential cation channel, subfamily more	81.14(n) 88.89(a)		418989 XM_003640588.1 XP_003640636.1
lizard (Anolis carolinensis)	Reptilia	TRPC6⁶	--	86(a)	1 ↔ 1	3(192753779-192785237)
zebrafish (Danio rerio)	Actinopterygii	LOC100333090¹	transient receptor potential cation channel, subfamily more	70.88(n) 80.05(a)		100333090 XM_002665399.1 XP_002665445.1
honey bee (Apis mellifera)	Insecta	--	--	28(a)	1 → many	GroupUn.1268(2616-22451)
worm (Caenorhabditis elegans)	Secernentea	trp-1^{1 , 3}	Transient-receptor-potential (trp) protein³ Protein TRP-1¹	36(a)³ 51.52(n)¹ 41.42(a)¹		III(8607645-8614376)³ 176202¹ NM_001047424.1¹ NP_001040889.1¹

ENSEMBL Gene Tree for TRPC6 (if available)
TreeFam Gene Tree for TRPC6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TRPC6 gene

TRPC4² TRPC1² TRPC7² TRPC5² TRPC3²

6 SIMAP similar genes for TRPC6 using alignment to 2 protein entries: TRPC6_HUMAN (see all proteins):

TRPC3 TRPC7 TRP7 TRPC4 TRPC5 TRPC1

TRPC6 for paralogs About GeneDecksing

5/11 Pseudogenes.org Pseudogenes for TRPC6 (see all 11)
PGOHUM00000242910 PGOHUM00000239435 PGOHUM00000245787 PGOHUM00000235165 PGOHUM00000235416

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs121434391^1,2	C,F,	pathogenic	136064605(-)	`GGCCAA/GTGAGC`	2	N S	mis¹		1		NA	4550
rs72984206^1,2	C,	--	97256303(+)	`GCTGAC/TAGTGC`	1	--	ds500¹		0	--	--	--	--
rs117895343^1,2	C,F,	--	97256664(+)	`TCATCA/G/TCTTTT`	2	--	ut3¹		1		EA	120
rs116690727^1,2	C,	--	97256708(+)	`AGTAAC/AAACAA`	1	--	ut3¹		1		WA	118
rs142655335^1,2	C,	--	97256715(+)	`ACAACA/CACCTC`	1	--	ut3¹		0	--	--	--	--
rs146033736^1,2	C,	--	97256783(+)	`ACATAC/TTGAAA`	1	--	ut3¹		0	--	--	--	--
rs138558920^1,2	C,	--	97256793(+)	`AATAAC/GAGATA`	1	--	ut3¹		0	--	--	--	--
rs112916171^1,2	C,	--	97257227(+)	`TATCAA/GTCATG`	1	--	ut3¹		2		CSA WA	120
rs149303118^1,2	C,	--	97257237(+)	`GTGCAC/TTGAGG`	1	--	ut3¹		0	--	--	--	--
rs144714163^1,2	C,	--	97257420(+)	`AGTAAC/TGTGGG`	1	--	ut3¹		0	--	--	--	--
rs190606820^1,2	C,	--	97257539(+)	`CAACTA/GGGCAT`	1	--	ut3¹		0	--	--	--	--
rs182894539^1,2	C,	--	97257684(+)	`GCACTG/TAAGAA`	1	--	ut3¹		0	--	--	--	--
rs201285907^1,2	C,	--	97257717(+)	`CTTCAA/CGTGGA`	1	--	ut3¹		0	--	--	--	--
rs187970274^1,2	C,F,	--	97257748(+)	`AGGAAG/ATCTTC`	1	--	ut3¹		1		EU	1323
rs148529934^1,2	C,	--	97257842(+)	`TATTCT/CGAGAT`	2	/Q /R	mis¹		1		NA	4540
rs202112361^1,2	C	--	97257941(+)	`TATAAA/GTACGC`	1	--	int¹		1		EU	1311
rs200719074^1,2	C,	--	97258565(+)	`TCAGGG/TTCATG`	1	--	int¹		0	--	--	--	--
rs199687626^1,2	C	--	97259806(+)	`AAAATC/TCATGC`	1	--	int¹		1		EU	1285
rs72984209^1,2	C,F,	--	97259855(+)	`AGATGG/AAAATC`	2	/F	syn¹		6		CSA WA NA EU	6056
rs41302373^1,2		--	97260464(+)	`AGGCAA/GATAAC`	1	--	int¹		0	--	--	--	--
rs79622590^1,2	C,F,	--	97260708(+)	`ATAAAT/GGAACA`	1	--	int¹		2		WA NA	238
rs75053819^1,2	F,	--	97260972(+)	`CAAAAC/TGAGCA`	1	--	int¹		1		WA	118
rs7480272^1,2	H	--	97261694(+)	`CAGTTT/ACTAAT`	1	--	int¹		4		NS EA	412
rs7126090^1,2	C,F,H,	--	97262718(+)	`GTTAAC/GTTTAA`	1	--	int¹		8		NS EA NA WA	538
rs12289447^1,2	C,F,H,	--	97263944(+)	`GAAAAG/TAGATA`	1	--	int¹ trp³		12		NS EA WA NA	1886
rs11826762^1,2	C,F,A,H,	--	97264051(+)	`GGAACG/AGGAGA`	1	--	int¹		9		NS EA NA CSA WA	656
rs11822237^1,2	C,F,A,H,	--	97264157(+)	`AACGGC/TACATC`	1	--	int¹		19		NS EA NA CSA WA	2310
rs112084998^1,2	C,	--	97264172(+)	`TAGCTG/ACCAGA`	1	--	int¹		1		NA	2
rs117175725^1,2	C,F,	--	97264174(+)	`GCTGCC/TAGAAG`	1	--	int¹		1		EA	120
rs36087810^1,2	C,F,	--	97264847(+)	`ATCTTC/TTGAGT`	1	--	int¹		4		NA	126
rs72984228^1,2	C,F,	--	97265199(+)	`ATTTTA/GTGTAA`	1	--	int¹		1		NA	120
rs77612469^1,2	C,	--	97265689(+)	`TCTTGG/AGACTA`	1	--	int¹		1		WA	2
rs79291645^1,2		--	97265693(+)	`GAGACC/TAATAA`	1	--	int¹		0	--	--	--	--
rs75495763^1,2	C,F,	--	97265779(+)	`GAAATG/TTCACC`	1	--	int¹		1		WA	118
rs57484369^1,2	C,F,	--	97266673(+)	`CAAGGA/GAGAGG`	1	--	int¹		1		WA	118
rs10895111^1,2	C,F,A,H,	--	97267242(+)	`ATGAGC/TGTGGA`	1	--	int¹		19		NS EA NA WA	2306
rs57153009^1,2		--	97271869(+)	`AACTGC/GGTACC`	1	--	int¹		0	--	--	--	--
rs4131266^1,2	H	--	97272437(-)	`GTTATC/TATGAA`	1	--	int¹		1		NS	120
rs75226820^1,2	C,	--	97272677(+)	`AACCAC/TTGAAC`	1	--	int¹		1		WA	2
rs7940955^1,2	C,H,	--	97273612(+)	`TGCAGG/ATCTTA`	1	--	int¹		4		NS EA	418
rs17093587^1,2	C,F,H,	--	97273841(+)	`TCCATC/TGCTTC`	1	--	int¹		19		NA NS EA CSA WA	2046
rs12800530^1,2	H	--	97274026(+)	`AAATGT/GACATG`	1	--	int¹		4		NS EA	416
rs61732606^1,2	F	--	97274258(+)	`AAAGGT/GCTTCA`	2	/D /A	mis¹		1		NS	56
rs79017821^1,2		--	97274445(+)	`CAAGTA/GCTTGC`	1	--	int¹		0	--	--	--	--
rs79606784^1,2	C,	--	97275247(+)	`CCTCCC/TCCTCT`	1	--	int¹		1		WA	2
rs11224774^1,2	H	--	97275384(+)	`CATATC/TTGAAC`	1	--	int¹		4		NS EA	404
rs11224775^1,2	H	--	97275429(+)	`taaatC/Tttttt`	1	--	int¹		4		NS EA	386
rs11224776^1,2	H	--	97275530(+)	`CTGGTC/TTCCCA`	1	--	int¹		4		NS EA	416
rs11224777^1,2	C,H	--	97275559(+)	`GATTTC/TTGAAC`	1	--	int¹		5		NS EA NA	404
rs11224778^1,2	H	--	97275584(+)	`GCTATC/TTAAGA`	1	--	int¹		4		NS EA	418
rs144927067^1,2	C	--	97276005(+)	`AAACCT/GTTTTT`	2	/K /N	mis¹		1		NA	4546
rs145077205^1,2	C,F,	--	97276992(+)	`ACCATA/C/TGTAAC`	3	T	syn¹		2		NA EU	5805
rs61743044^1,2	C,F,	--	97277019(+)	`AGAACG/ATAACC`	2	/Y	syn¹		5		NS CSA NA EU	5820
rs61739601^1,2	C,F,	--	97277046(+)	`TTGTGG/ATTATA`	2	/N	syn¹		3		NS CSA NA	4325
rs60003016^1,2		--	97277328(+)	`ATGAAG/TTACAT`	1	--	int¹		0	--	--	--	--
rs75591943^1,2	C,	--	97277539(+)	`AGACAT/ATGTTA`	1	--	int¹		1		WA	2
rs35713949^1,2	C,	--	97277763(+)	`TTATG-/AAAAAA`	1	--	int¹		2		NA CSA	4
rs79995435^1,2	C,F,	--	97277784(+)	`CCATGG/ATGAAC`	1	--	int¹		1		EA	120
rs187196477^1,2	C,	--	97278410(+)	`AAGATA/GTCTTT`	2	D	syn¹		0	--	--	--	--
rs200087630^1,2	C,	--	97278418(+)	`TTTGAC/TTGTTC`	2	I V	mis¹		0	--	--	--	--
rs61745699^1,2	F	--	97278421(+)	`GACTGT/GTCTTC`	2	/T /P	mis¹		1		NS	42
rs139187399^1,2	C,F,	--	97278491(+)	`GAGAAA/GCTTAA`	2	S	syn¹		1		NA	4478
rs111550859^1,2		--	97278636(+)	`TTCTGC/TGAAAG`	1	--	int¹		1		CSA	2
rs74451914^1,2		--	97278834(+)	`ATTCAC/TGTATG`	1	--	int¹		0	--	--	--	--
rs78181121^1,2	F,	--	97279037(+)	`AAACTA/GTAATT`	1	--	int¹		1		WA	118
rs75583297^1,2	F,	--	97279279(+)	`TTTGTA/GTTTGC`	1	--	int¹		1		WA	118
rs78688863^1,2	C,F,	--	97279559(+)	`TTTTCC/TCCATC`	1	--	int¹		1		WA	118
rs112150278^1,2		--	97279611(+)	`GACCAG/ATTTCC`	1	--	int¹		1		CSA	2
rs72984259^1,2	C,F,	--	97279976(+)	`TCTAAG/TCCTGG`	1	--	int¹		4		CSA WA NA	242
rs76481744^1,2	C,F,	--	97280290(+)	`CTATAC/TTGTAT`	1	--	int¹		1		EA	120
rs78340860^1,2		--	97280335(+)	`TATTAT/CAAGCT`	1	--	int¹		2		CSA WA	120
rs80111499^1,2	F,	--	97280408(+)	`GGCCAA/GCATCT`	1	--	int¹		1		NA	120
rs7127346^1,2	C,F,H,	--	97280564(+)	`tcttcC/Tgagtt`	1	--	int¹		12		NS EA NA WA CSA	1011
rs201804897^1,2	C	--	97280654(+)	`ACACAC/TANNNN`	1	--	int¹		0	--	--	--	--
rs76277340^1,2	F,	--	97280950(+)	`CATATA/CGATGC`	1	--	int¹		1		NA	120
rs201064728^1,2	C,	--	97281205(+)	`AATCTC/TGCAAT`	2	A	syn¹		0	--	--	--	--
rs150183033^1,2	C,F	--	97281223(+)	`GCTGCG/AAAAAT`	2	/F	syn¹		1		NA	4550
rs200561342^1,2	C,	--	97281317(+)	`CCCATA/GTCATG`	2	T I	mis¹		0	--	--	--	--
rs77502518^1,2	F,	--	97281535(+)	`GTTCAT/CTGAAC`	1	--	int¹		1		WA	118
rs76539016^1,2		--	97281968(+)	`ACTGTG/ATAAAG`	1	--	int¹		2		CSA WA	120
rs57592165^1,2	C,F,	--	97282107(+)	`TTAATA/GAAATT`	1	--	int¹		5		NA WA CSA	243
rs76256509^1,2	F,	--	97282440(+)	`GCTATG/CAAGTC`	1	--	int¹		1		WA	118
rs7927507^1,2	C,F,	--	97282609(+)	`TTATTG/AAGTGC`	1	--	int¹		2		WA NA	238
rs115999712^1,2	C,F,	--	97282975(+)	`GAGCAC/TGTCAT`	1	--	int¹		1		WA	118
rs75380375^1,2		--	97283026(+)	`ACATGG/AATTTA`	1	--	int¹		1		NA	120
rs80016123^1,2	F,	--	97283162(+)	`GTCCCC/TGGGCT`	1	--	int¹		1		NA	120
rs7114045^1,2	C,F,H,	--	97284492(+)	`GGCTAC/TAAAAG`	1	--	int¹		9		NS EA NA WA	1210
rs17740759^1,2	C,F,H,	--	97284588(+)	`GACAAA/GAGTTA`	1	--	int¹		19		NA NS EA	2226
rs7925826^1,2	C,A,	--	97284761(+)	`tcaccG/Tgaggt`	1	--	int¹		0	--	--	--	--
rs7130287^1,2	C,F,H,	--	97285018(+)	`CTAGTA/GTGAGG`	1	--	int¹		5		NS EA WA	536
rs7115010^1,2	C,F,H,	--	97285131(+)	`CCAGGC/AGTGAT`	1	--	int¹		10		NS EA NA WA	1210
rs7103383^1,2	C,H,	--	97285166(+)	`GAGACT/AGCAGT`	1	--	int¹		4		NS EA WA	414
rs78685448^1,2	F,	--	97285506(+)	`AATTGT/CAATTA`	1	--	int¹		1		WA	118
rs75353850^1,2	F,	--	97285534(+)	`ATGTCC/TGTTGT`	1	--	int¹		1		WA	118
rs76053917^1,2	C,	--	97285639(+)	`CAAGTG/CATTGT`	1	--	int¹		2		WA	120
rs56318611^1,2	C,F,	--	97285759(+)	`CAAGAT/GTTATC`	1	--	int¹		1		NA	120
rs79240919^1,2	F,	--	97285927(+)	`ATTTTG/CACTGA`	1	--	int¹		1		WA	118
rs79300862^1,2	C,F,	--	97286144(+)	`CATAAT/CTTTAT`	1	--	int¹		1		NA	120
rs75588138^1,2	C,	--	97286306(+)	`ACTTT-/AATCAG`	1	--	int¹		1		CSA	2
rs79377675^1,2		--	97286529(+)	`CTTCCA/GTTGAG`	1	--	int¹		1		EA	120
rs74674181^1,2	C,	--	97286581(+)	`ACCACT/CGTGAC`	1	--	int¹		2		WA	120
rs77946963^1,2	C,	--	97287035(+)	`ATCCTC/TGTTAC`	1	--	int¹		3		NA WA	240
rs75208058^1,2	C,	--	97287275(+)	`TTATAG/AACTAG`	1	--	int¹		1		WA	2
rs72984281^1,2	C,	--	97287315(+)	`TTGATG/TTATAT`	1	--	int¹		0	--	--	--	--
rs111504486^1,2	C,	--	97287599(+)	`NNNNTG/ATACTT`	1	--	int¹		2		NA	122
rs112258968^1,2	C,F,	--	97287920(+)	`GCTGCG/ATGTGC`	2	/H	syn¹		3		CSA WA NA	4667
rs11826302^1,2	C,F,H,	--	97288100(+)	`NNNNCG/ATGATA`	1	--	int¹		8		NS EA NA CSA WA	658
rs112665005^1,2		--	97288341(+)	`AAACTG/AAGTCT`	1	--	int¹		2		CSA WA	120
rs57046227^1,2	C,	--	97288567(+)	`TCCAAC/TATTTT`	1	--	int¹		1		WA	2
rs7942339^1,2	C,F,A,H,	--	97289194(+)	`ATCTTT/GTAAGA`	1	--	int¹		23		NS EA NA WA CSA	2544
rs74837233^1,2	F,	--	97289365(+)	`AGATAT/CTGTAT`	1	--	int¹		1		WA	118
rs11325078^1,2	C	--	97290084(+)	`TTTTG-/TTTTTT`	1	--	int¹ trp³		1		NA	2
rs73587985^1,2	C,	--	97290138(+)	`AAATTC/AAAACA`	1	--	int¹		1		WA	2
rs79766398^1,2	F,	--	97290141(+)	`TTAAAA/CCAAAT`	1	--	int¹		1		EA	120
rs34136693^1,2	C,	--	97290394(+)	`TTTTT-/AAATTC`	1	--	int¹		0	--	--	--	--
rs12577872^1,2	H	--	97290552(+)	`GTAGAA/CCCAAA`	1	--	int¹		4		NS EA	418
rs75533367^1,2	C,	--	97290581(+)	`NNNNCG/AAGGTT`	1	--	int¹		3		NA WA	240
rs10567537^1,2	C	--	97290890(+)	`TTTTC-/TTGTT TTGTT`	1	--	int¹		0	--	--	--	--
rs78629399^1,2		--	97291859(+)	`AAAGGA/TAATCA`	1	--	int¹		0	--	--	--	--
rs78799867^1,2		--	97292501(+)	`GCACTA/GTTTTC`	1	--	int¹		0	--	--	--	--
rs77392646^1,2	F,	--	97292666(+)	`TTCCAC/GTGTCT`	1	--	int¹		1		WA	118
rs111626998^1,2	C,	--	97292808(+)	`TATTAC/TGAATG`	1	--	int¹		1		NA	2
rs77085349^1,2	F,	--	97292821(+)	`TGAAAA/GTGAAT`	1	--	int¹		1		WA	118
rs7945727^1,2	C,F,H,	--	97293181(+)	`TGTACT/GTAGTC`	1	--	int¹		103		NS EA NA PA EU CA WA CSA	6408
rs78668656^1,2	C,	--	97293501(+)	`ACAGGT/CGAATT`	1	--	int¹		3		NA WA	240
rs138155461^1,2	C,F,	--	97293771(+)	`AGAGCC/TAGGAA`	2	L	syn¹		1		NA	4552
rs144085223^1,2	C,F	--	97293819(+)	`TTGACC/TGCCAT`	2	A	syn¹		1		NA	4552
rs146132521^1,2	C,	--	97293932(+)	`TAAATC/TTGACT`	1	--	int¹		0	--	--	--	--
rs35938177^1,2	C	--	97294433(+)	`CAATA-/TTTTTTTT`	1	--	int¹		0	--	--	--	--
rs80219157^1,2	F,	--	97294603(+)	`GGTTAT/CATAGA`	1	--	int¹		2		WA NA	238
rs7935628^1,2	C,F,A,H,	--	97294869(+)	`TTCCAC/TATGTA`	1	--	int¹		9		EA NS NA WA	874
rs59377709^1,2	C,F,	--	97296125(+)	`GGGAGT/GCTGAG`	1	--	int¹		3		WA CSA	5
rs139477687^1,2	C	--	97296528(+)	`TAGTCA/GTTCTA`	2	N	syn¹		1		NA	4550
rs111367906^1,2	C	--	97296628(+)	`ACATTC/TTTTTT`	1	--	int¹		1		CSA	2
rs74966448^1,2		--	97297273(+)	`TACTCA/CGGAGG`	1	--	int¹		3		CSA WA NA	240
rs77795328^1,2	C,F,	--	97298351(+)	`TATCTC/TTCTTA`	1	--	int¹		1		WA	118
rs12283329^1,2	C,F,H,	--	97298564(+)	`TTTGGA/TAAGTT`	1	--	int¹		21		NA NS EA CSA WA	2184
rs80170900^1,2	F,	--	97299071(+)	`CTTTAA/CTATGT`	1	--	int¹		1		WA	118
rs111628817^1,2		--	97301490(+)	`AGCTTG/AGAGAG`	1	--	int¹		1		CSA	2
rs75947406^1,2	F,	--	97301834(+)	`TTTTGC/GTAACC`	1	--	int¹		1		WA	118
rs111282311^1,2		--	97301840(+)	`TAACCG/AATGTA`	1	--	int¹		1		CSA	2
rs78691788^1,2	C,	--	97303827(+)	`AGACAG/CAAACA`	1	--	int¹		1		WA	2
rs79163741^1,2	C,	--	97303834(+)	`AACAAG/TGGCCA`	1	--	int¹		1		WA	2
rs79866909^1,2	F,	--	97304127(+)	`TTTTAC/TAGGAA`	1	--	int¹		1		NA	120
rs79940733^1,2	F,	--	97306811(+)	`GTTTTC/TAGTTA`	1	--	int¹		1		WA	118
rs111608338^1,2		--	97307206(+)	`GATTAC/TAAACC`	1	--	int¹		1		CSA	2
rs76712371^1,2		--	97307836(+)	`GCATAG/TAGAAA`	1	--	int¹		1		CSA	1
rs117849360^1,2	C,F,	--	97307847(+)	`AAAAAT/CGAAAC`	1	--	int¹		1		EA	120
rs17741616^1,2	C,F,H,	--	97307863(+)	`TTCACT/GTCTGT`	1	--	int¹		10		NA NS EA	686
rs142960327^1,2	C,	--	97308867(+)	`GGAGGA/GTGAAG`	1	--	int¹		0	--	--	--	--
rs144891994^1,2	C,F	--	97308951(+)	`AAAGCC/TGTCAT`	2	T	syn¹		2		NA EU	5873
rs147530677^1,2	C	--	97309002(+)	`GCCAGG/ACCTTT`	2	/G	syn¹		1		NA	4552
rs140242092^1,2	C	--	97309128(+)	`AGGAGG/TGTATG`	2	T	syn¹		1		NA	4550
rs150033580^1,2	C	--	97309172(+)	`AATGAT/CTGGAG`	2	/I /V	mis¹		1		NA	4550
rs149152923^1,2	C,F	--	97309362(+)	`ACTCGA/GGAGAG`	2	S	syn¹		1		NA	4546
rs35857503^1,2	C,F	--	97309369(+)	`AGAGGT/GTTTCT`	2	/N /T	mis¹		2		NA	64
rs146776939^1,2	C,F	--	97309465(+)	`TAACGT/CTGAGT`	2	/N /S	mis¹		1		NA	4550
rs145652328^1,2	C	--	97309571(+)	`GCGATC/TACTAA`	2	N D	mis¹		1		NA	4552
rs202083439^1,2	C	--	97309589(+)	`TGCTGG/TTCCTC`	2	T P	mis¹		1		EU	1323
rs138123801^1,2	C	--	97309626(+)	`CGGAGA/TACTGT`	2	V	syn¹		1		NA	4448
rs141153400^1,2	C	--	97309629(+)	`AGAACT/CGTCTG`	2	/T	syn¹		1		NA	4400
rs117273916^1,2	C,F,	--	97309667(+)	`TCCCCG/AGCTGC`	2	/R /W	mis¹		3		NA EU	4479
rs6590871^1,2	C,F,A,	--	97310615(+)	`tgctaT/Cggctc`	1	--	int¹		4		WA CSA NA	242
rs34875945^1,2	C,F,	--	97311048(+)	`TCACTG/AACTGA`	1	--	int¹		3		NA	6
rs75002973^1,2	F,	--	97311298(+)	`GCAGTG/ATGATG`	1	--	int¹		1		WA	118
rs116577782^1,2	C,F,	--	97311386(+)	`ATACCA/GCCATA`	1	--	int¹		1		WA	118
rs4754763^1,2	H	--	97311625(+)	`TGTCCC/TATAGC`	1	--	int¹		4		NS EA	418
rs77869143^1,2	F,	--	97312293(+)	`TATCAT/CTCCAA`	1	--	int¹		1		EA	120
rs61916028^1,2		--	97312322(+)	`TTTTGT/CATTGG`	1	--	int¹		3		NA WA	240
rs77785590^1,2	F,	--	97313061(+)	`CTCCTG/CAGTTG`	1	--	int¹		1		EA	120
rs201511589^1,2	C	--	97314488(+)	`CTTGGA/CAAGCC`	1	--	int¹		0	--	--	--	--
rs113363905^1,2	C,	--	97314502(+)	`AATCAC/TAATGA`	1	--	int¹		1		NA	2
rs77342481^1,2		--	97314839(+)	`CAGCAG/AGCACA`	1	--	int¹		2		CSA WA	120
rs73571972^1,2	C,	--	97315325(+)	`GCACAC/TTTTTC`	1	--	int¹		1		WA	2
rs115378538^1,2	C,F,	--	97316089(+)	`CATTTT/CACAAC`	1	--	int¹		1		WA	118
rs72972209^1,2	C,F,	--	97316999(+)	`TTCCAG/CATAGT`	1	--	int¹		1		NA	120
rs72972215^1,2	C,F,	--	97317883(+)	`NNNNCA/GTGAAG`	1	--	int¹		1		NA	120
rs73571974^1,2	C,	--	97318355(+)	`CACAAC/ACTGTT`	1	--	int¹		2		WA	120
rs11224810^1,2	F,	--	97319321(+)	`AGGAGG/CGAAGA`	1	--	int¹ trp³		6		NA CSA WA	245
rs113870283^1,2		--	97319701(+)	`AATAAC/TTGTGG`	1	--	int¹		1		CSA	2
rs75243426^1,2	C,	--	97319780(+)	`GCAAAT/ATATTT`	1	--	int¹		1		WA	2
rs12277875^1,2	C,F,H,	--	97319854(+)	`CTGTGT/CCNNNN`	1	--	int¹		9		NS EA NA CSA WA	505
rs111350398^1,2		--	97320354(+)	`CTGAAC/TTTATC`	1	--	int¹		1		CSA	2
rs112231381^1,2	C,	--	97320912(+)	`ACAGGC/TATGGC`	1	--	int¹		1		NA	2
rs111356441^1,2		--	97321764(+)	`CGAGAG/AAGGGC`	1	--	int¹		1		CSA	2
rs77250557^1,2	C,F,	--	97322643(+)	`ACTAAC/TTTGCC`	1	--	int¹		1		WA	118
rs75782833^1,2	F,	--	97322729(+)	`TGTTAT/CTGAAA`	1	--	int¹		1		NA	120
rs10501982^1,2	C,F,H,	--	97322858(+)	`ACTGTG/AGCCAA`	1	--	int¹		93		NS EA PA EU CA WA NA CSA	5212
rs113318605^1,2		--	97322897(+)	`AAAGTT/CGTTTG`	1	--	int¹		2		CSA WA	120
rs78928308^1,2	F,	--	97324046(+)	`TATTTA/TAAAAT`	1	--	int¹		1		WA	118
rs12275715^1,2	F,H,	--	97324592(+)	`ctcaaA/Tatgta`	1	--	int¹		8		NS EA NA WA	662
rs73571982^1,2	C,	--	97324641(+)	`GGCATC/GTAGAT`	1	--	int¹		2		WA	120
rs113276686^1,2	C,	--	97324662(+)	`GATTCG/AATGAC`	1	--	int¹		2		WA	120
rs12277494^1,2	F,H,	--	97325369(+)	`aaagcA/Gacttt`	1	--	int¹		6		NS EA WA NA	658
rs77982636^1,2	F,	--	97325721(+)	`TCAGAG/CTGATG`	1	--	int¹		1		WA	118
rs12279399^1,2	F,H,	--	97326437(+)	`tccctA/Gctgca`	1	--	int¹		4		NS EA	420
rs11820765^1,2	H	--	97326557(+)	`accagC/Gccttg`	1	--	int¹		0	--	--	--	--
rs113464143^1,2		--	97326769(+)	`CTCCCC/TTTTGG`	1	--	int¹		2		CSA WA	120
rs61916050^1,2		--	97326805(+)	`TACCCC/TTGTCG`	1	--	int¹		2		NA	122
rs76672375^1,2	F,	--	97327396(+)	`AGTCAC/ACTTCT`	1	--	int¹		1		WA	118
rs72972234^1,2		--	97328171(+)	`AGGATA/GAGAGA`	1	--	int¹		0	--	--	--	--
rs61916051^1,2		--	97328315(+)	`ATTTCT/AAAGAT`	1	--	int¹		2		NA	122
rs17096854^1,2	C,F,	--	97328550(+)	`CTTATT/CGTTAG`	1	--	int¹		3		NA	140
rs75470260^1,2		--	97329029(+)	`ACAGCC/TTTCCA`	1	--	int¹		1		WA	118
rs4271352^1,2	C,A,	--	97329319(+)	`gagacG/Agggtt`	1	--	int¹		1		NA	2
rs112854637^1,2	C,	--	97329350(+)	`GTCTCG/AATCTC`	1	--	int¹		1		WA	2
rs77835679^1,2	F,	--	97329478(+)	`CTACCG/ATTAAA`	1	--	int¹		1		WA	118
rs80199967^1,2	C,F,	--	97329856(+)	`ATCAAT/CCAAGT`	1	--	int¹		1		WA	118
rs77869002^1,2	F,	--	97330278(+)	`CCGACA/GGCAAA`	1	--	int¹		1		NA	120
rs76721703^1,2	F,	--	97330286(+)	`AAAGAT/GGCTTA`	1	--	int¹		1		NA	120
rs17096867^1,2	C,	--	97330471(+)	`AACTTG/AGGAGT`	1	--	int¹		4		NA WA	258
rs17096869^1,2	C,F,H,	--	97330508(+)	`GAGAAC/TGTAAC`	1	--	int¹		12		NA NS EA CSA WA	1350
rs4754764^1,2	H	--	97330510(+)	`GAACGT/GAACAC`	1	--	int¹		4		NS EA	416
rs55790845^1,2	C,F,	--	97330545(+)	`ATACAC/TTTTGA`	1	--	int¹		1		NA	120
rs200404332^1,2	C	--	97330749(+)	`GGCTAA/CAAGCC`	1	--	int¹		0	--	--	--	--
rs72972239^1,2	C,F,	--	97330768(+)	`GGCCTA/CAAGGA`	1	--	int¹		1		NA	120
rs75796094^1,2		--	97331026(+)	`GAAAGG/AGTATA`	1	--	int¹		1		WA	118
rs76829308^1,2	C,	--	97331265(+)	`CATGCT/CTTGAA`	1	--	int¹		4		NA CSA WA	241
rs73575707^1,2	C,	--	97331355(+)	`TACTGA/TGTGAA`	1	--	int¹		2		WA	120
rs4466798^1,2	C,F,A,H,	--	97332584(+)	`TTTTTC/TCTATA`	1	--	int¹ trp³		15		NS EA NA WA CSA	1194
rs112913643^1,2	C,	--	97333576(+)	`CTGAAA/GAACAT`	1	--	int¹		2		CSA WA	120
rs112493994^1,2		--	97333718(+)	`AAGAAA/GTAATC`	1	--	int¹		2		CSA WA	120
rs113951627^1,2		--	97333756(+)	`ATCTGC/GAATCA`	1	--	int¹		1		CSA	1
rs78845002^1,2	F,	--	97334544(+)	`GTTTTT/CATAAA`	1	--	int¹		1		NA	120
rs76616052^1,2	C,F,	--	97334643(+)	`ACTGAT/CAGAAG`	1	--	int¹		3		WA CSA	122
rs79968676^1,2		--	97334881(+)	`CACCCA/GTGCCT`	1	--	int¹		1		WA	118
rs78333655^1,2	C,F,	--	97335287(+)	`GATACG/ACCCAT`	1	--	int¹		1		WA	118
rs74589053^1,2	C,F,	--	97335586(+)	`AGCTCG/AAGCCC`	1	--	int¹		4		NA CSA WA	242
rs4254048^1,2	C,F,A,H,	--	97336212(+)	`ttgtcT/Ctggta`	1	--	int¹		14		NS EA NA WA	1086
rs79744592^1,2	F,	--	97336988(+)	`GTATCC/TTGAAG`	1	--	int¹		1		WA	118
rs61916052^1,2		--	97337457(+)	`GGAGCG/AGACAA`	1	--	int¹		1		NA	2
rs202185036^1,2	C	--	97337890(-)	`GTTTGG/TGGCTC`	1	--	int¹		0	--	--	--	--
rs78752240^1,2	F,	--	97337900(+)	`CCGAGA/GAGGTC`	1	--	int¹		1		NA	120
rs190005454^1,2	C,	--	97338007(+)	`TGGGAA/GTNNNN`	1	--	int¹		0	--	--	--	--
rs12290423^1,2	F,H,	--	97338122(+)	`gaagcA/Ttagtg`	1	--	int¹		5		NS EA WA	538
rs78693717^1,2	C,F,	--	97338453(+)	`CTGAAG/ATGCCA`	1	--	int¹		3		WA CSA	122
rs7931676^1,2	C,F,A,H,	--	97339351(+)	`GTATCA/GTTTCA`	1	--	int¹		19		NS EA NA	2194
rs12294092^1,2	C	--	97340095(+)	`ggaagG/AaaACA`	1	--	int¹ trp³		1		NA	2
rs73575715^1,2	C,	--	97340115(+)	`TGAGGA/GGACAA`	1	--	int¹		2		WA	120
rs58541860^1,2	C,F,	--	97340314(+)	`GTCTAT/CTTCTC`	1	--	int¹		4		WA CSA NA	242
rs80185301^1,2	C,	--	97340605(+)	`AATACT/CGTGTA`	1	--	int¹		2		WA	120
rs73575719^1,2	C,	--	97340734(+)	`ATCATG/CCTTGA`	1	--	int¹		2		WA	120
rs12421364^1,2	C,F,H,	--	97341154(+)	`ggatcG/Acttga`	1	--	int¹		5		NS EA NA	410
rs112490409^1,2		--	97341269(+)	`AAAAAA/TAGAAA`	1	--	int¹		2		CSA WA	120
rs17096881^1,2	C,F,	--	97341307(+)	`AGAGTG/ATGGTA`	1	--	int¹		4		NA WA	260
rs7932074^1,2	C,F,A,H,	--	97341890(+)	`TAAATG/TTGTTT`	1	--	int¹		8		NS EA NA WA	680
rs7950828^1,2	C,F,A,H,	--	97342090(+)	`TCAACT/CACACC`	1	--	int¹		10		NS EA NA WA	670
rs7933194^1,2	C,F,A,H,	--	97342161(+)	`TTTATC/TCCACA`	1	--	int¹		4		NS EA	418
rs7925662^1,2	C,F,H,	--	97342427(+)	`TTTTCT/CAGAAA`	1	--	int¹		20		NS EA NA	2390
rs78606406^1,2	F,	--	97342694(+)	`ATTATT/CTTCTC`	1	--	int¹		1		EA	120
rs112548654^1,2	C,	--	97343582(+)	`AACATG/AATAAA`	1	--	int¹		2		WA	120
rs4457714^1,2	C,F,A,H,	--	97343907(+)	`tacacG/Ttatgt`	1	--	int¹		26		NS EA NA WA CSA	2770
rs199584174^1,2	C	--	97343946(-)	`TAGTGA/TAAAAC`	1	--	int¹		0	--	--	--	--
rs79548044^1,2		--	97344119(+)	`AACTCT/CGAGGC`	1	--	int¹		1		WA	118
rs56743893^1,2	C,F,	--	97344255(+)	`TGTGCG/AGNNNN`	1	--	int¹		6		WA NA CSA	246
rs7112388^1,2	C,F,H,	--	97345229(+)	`ATTTTT/CCTTAA`	1	--	int¹		12		NS EA NA WA CSA	1014
rs7112255^1,2	C,F,A,H,	--	97345318(+)	`TATGTA/GGTGTT`	1	--	int¹		35		EA NA NS WA CSA	3231
rs6590880^1,2	C,F,A,H,	--	97345452(+)	`TATTTC/TATCAA`	1	--	int¹		21		NA NS EA WA CSA	1239
rs112563237^1,2		--	97345556(+)	`GTTCTG/AAAATA`	1	--	int¹		1		CSA	2
rs6590881^1,2	C,F,A,H,	--	97345579(+)	`GAGTAT/CGAACT`	1	--	int¹		16		NA NS EA WA CSA	815
rs6590882^1,2	C,F,A,H,	--	97345721(+)	`GGAATC/TGTGAG`	1	--	int¹		22		NA NS EA WA	2302
rs78281008^1,2		--	97345722(+)	`GAATCG/ATGAGG`	1	--	int¹		1		WA	118
rs4469859^1,2	C,F,A,H,	--	97345877(+)	`CGTAGG/TCTAAC`	1	--	int¹		12		EA NS NA WA CSA	564
rs7938237^1,2	C,F,H,	--	97345920(+)	`TTTTAT/AGAATT`	1	--	int¹		5		NS EA WA	530
rs4474404^1,2	C,F,A,H,	--	97346242(+)	`ctttcG/Acccag`	1	--	int¹		5		NA CSA WA	245
rs7951375^1,2	C,F,	--	97346272(+)	`atctcG/Agctca`	1	--	int¹		1		WA	118
rs12786923^1,2	H	--	97346851(+)	`TGTTAG/CGTCTA`	1	--	int¹		4		NS EA	420
rs12786924^1,2	H	--	97346852(+)	`GTTAGG/CTCTAA`	1	--	int¹		4		NS EA	420
rs11224830^1,2	C,F,H,	--	97347037(+)	`GACACG/AGNNNN`	1	--	int¹		11		NS EA NA CSA WA	804
rs7131328^1,2	C,F,A,H,	--	97347132(+)	`ATAGGG/ATGCTA`	1	--	int¹		11		NA NS EA WA	802
rs11224831^1,2		--	97347830(+)	`AAATGC/TTAAAA`	1	--	int¹		0	--	--	--	--
rs7125321^1,2	C,A,	--	97348225(+)	`tttcaT/Aatgga`	1	--	int¹		1		NA	2
rs11224836^1,2		--	97348323(+)	`ATAAGA/GCTACA`	1	--	int¹		0	--	--	--	--
rs7935364^1,2	C,	--	97349637(+)	`gatggA/Gtgcag`	1	--	int¹		0	--	--	--	--
rs61916053^1,2	C,	--	97349866(+)	`TGAAGA/GTCACC`	1	--	int¹		4		NA WA	242
rs77542509^1,2	C,	--	97349936(+)	`ATTAGT/CCTTTA`	1	--	int¹		2		NA	122
rs10541770^1,2	C	--	97350049(+)	`ATTTG-/AAAT AAATA`	1	--	int¹		0	--	--	--	--
rs76879966^1,2		--	97350392(+)	`AAATAG/ACTTTC`	1	--	int¹		1		WA	118
rs79817589^1,2	F,	--	97350554(+)	`GTTGCC/TCCCTA`	1	--	int¹		1		WA	118
rs79005670^1,2	C,	--	97350557(+)	`GCCCCC/GTATTT`	1	--	int¹		2		NA	122
rs75693637^1,2	F,	--	97351355(+)	`AAAGGA/CTGGTA`	1	--	int¹		1		NA	120
rs77550382^1,2	F,	--	97351978(+)	`ATCTAT/CTGGCT`	1	--	int¹		1		WA	118
rs73575787^1,2	C,	--	97352066(+)	`ATTACG/ATCAAC`	1	--	int¹		4		WA CSA NA	241
rs76286396^1,2	C,	--	97352143(+)	`TAGAAC/AGCAAT`	1	--	int¹		1		WA	2
rs79725741^1,2	F,	--	97352288(+)	`GGGCAC/AACAGG`	1	--	int¹		1		WA	118
rs7942189^1,2	C,	--	97352719(+)	`TTATCA/GTCTCA`	1	--	int¹		3		CSA WA NA	240
rs10895138^1,2	C,A,H,	--	97353084(+)	`ATTCTA/GTTTTT`	1	--	int¹		3		NA WA	240
rs76715431^1,2	C,	--	97353101(+)	`ACACC-/GWTTCT`	1	--	int¹		0	--	--	--	--
rs75884666^1,2	C	--	97353102(+)	`CACCAA/G/TTTCTC`	1	--	int¹		0	--	--	--	--
rs73575794^1,2	C,F,	--	97353700(+)	`CACTTT/CTGTAA`	1	--	int¹		5

Advanced Search

Export list of displayed genes

TRPC6 Gene

transient receptor potential cation channel, subfamily C,...

Aliases
for TRPC6 gene

Summaries
for TRPC6 gene

Genomic Views
for TRPC6 gene

Proteins
for TRPC6 gene

Protein Domains /
Families
for TRPC6 gene

Function
for TRPC6 gene

Pathways & Interactions
for TRPC6 gene

Drugs & Compounds
for TRPC6 gene

Transcripts
for TRPC6 gene

Expression
for TRPC6 gene

Orthologs
for TRPC6 gene

Paralogs
for TRPC6 gene

Genomic Variants
for TRPC6 gene

Advanced Search

Export list of displayed genes

TRPC6 Gene

transient receptor potential cation channel, subfamily C,...

Aliasesfor TRPC6 gene

Summariesfor TRPC6 gene

Genomic Viewsfor TRPC6 gene

Proteinsfor TRPC6 gene

Protein Domains /Familiesfor TRPC6 gene

Functionfor TRPC6 gene

Pathways & Interactionsfor TRPC6 gene

Drugs & Compoundsfor TRPC6 gene

Transcriptsfor TRPC6 gene

Expression for TRPC6 gene

Orthologsfor TRPC6 gene

Paralogsfor TRPC6 gene

Genomic Variantsfor TRPC6 gene

Aliases
for TRPC6 gene

Summaries
for TRPC6 gene

Genomic Views
for TRPC6 gene

Proteins
for TRPC6 gene

Protein Domains /
Families
for TRPC6 gene

Function
for TRPC6 gene

Pathways & Interactions
for TRPC6 gene

Drugs & Compounds
for TRPC6 gene

Transcripts
for TRPC6 gene

Expression
for TRPC6 gene

Orthologs
for TRPC6 gene

Paralogs
for TRPC6 gene

Genomic Variants
for TRPC6 gene