Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TRPC6 Gene

protein-coding   GIFtS: 67
GCID: GC11M101322

Transient Receptor Potential Cation Channel, Subfamily C,...

(Previous name: focal segmental glomerulosclerosis 2)
(Previous symbol: FSGS2)
  See TRPC6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Transient Receptor Potential Cation Channel, Subfamily C, Member 61 2     Transient Receptor Protein 62 3
FSGS21 2 5     TRP-62 3
TRP62 3 5     Short Transient Receptor Potential Channel 62
Focal Segmental Glomerulosclerosis 21 2     TrpC63

External Ids:    HGNC: 123381   Entrez Gene: 72252   Ensembl: ENSG000001376727   OMIM: 6036525   UniProtKB: Q9Y2103   
ORGUL members:         

Export aliases for TRPC6 gene to outside databases

Previous GC identifers: GC11M103516 GC11M102679 GC11M101356 GC11M100860 GC11M100827 GC11M097256


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TRPC6 Gene:
The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is
activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger
system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of
intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2).
(provided by RefSeq, Mar 2009)

GeneCards Summary for TRPC6 Gene:
TRPC6 (transient receptor potential cation channel, subfamily C, member 6) is a protein-coding gene. Diseases associated with TRPC6 include diencephalic neoplasm, and focal segmental glomerulosclerosis 2. GO annotations related to this gene include store-operated calcium channel activity and inositol 1,4,5 trisphosphate binding. An important paralog of this gene is TRPC4.

UniProtKB/Swiss-Prot: TRPC6_HUMAN, Q9Y210
Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated
by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled
receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C.
Seems not to be activated by intracellular calcium store depletion

Gene Wiki entry for TRPC6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRPC6 gene promoter:
         AhR   ISGF-3   AML1a   ATF-2   Arnt   CRE-BP1   CREB   deltaCREB   HOXA5   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRPC6 promoter sequence
   Search Chromatin IP Primers for TRPC6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRPC6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.1   Ensembl cytogenetic band:  11q22.1   HGNC cytogenetic band: 11q22.1

TRPC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRPC6 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M101322:  view genomic region     (about GC identifiers)

Start:
101,322,295 bp from pter      End:
101,743,293 bp from pter
Size:
420,999 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TRPC6_HUMAN, Q9Y210 (See protein sequence)
Recommended Name: Short transient receptor potential channel 6  
Size: 931 amino acids; 106326 Da
Subunit: Interacts with MX1 and RNF24
Secondary accessions: Q52M59 Q9HCW3 Q9NQA8 Q9NQA9
Alternative splicing: 3 isoforms:  Q9Y210-1   Q9Y210-2   Q9Y210-3   

Explore the universe of human proteins at neXtProt for TRPC6: NX_Q9Y210

Explore proteomics data for TRPC6 at MOPED

Post-translational modifications: 

  • Phosphorylated by FYN, leading to an increase of TRPC6 channel activity (By similarity)1
  • Glycosylation2 at Asn473, Asn561
  • Modification sites at PhosphoSitePlus

  • See TRPC6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004612.2  
    ENSEMBL proteins: 
     ENSP00000340913   ENSP00000435574   ENSP00000343672   ENSP00000353687  
    Reactome Protein details: Q9Y210

    TRPC6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TRPC6
    GenScript Custom Purified and Recombinant Proteins Services for TRPC6
    Novus Biologicals TRPC6 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRPC6

     
    Search eBioscience for Proteins for TRPC6 

    TRPC6 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TRPC6
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TRPC6
    OriGene Custom Antibody Services for TRPC6
    Novus Biologicals TRPC6 Antibodies
    Abcam antibodies for TRPC6
    Cloud-Clone Corp. Antibodies for TRPC6
    ThermoFisher Antibodies for TRPC6
    LSBio Antibodies in human, mouse, rat for TRPC6

    TRPC6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TRPC6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRPC6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TRPC6
    Cloud-Clone Corp. CLIAs for TRPC6
    Search eBioscience for ELISAs for TRPC6 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    TRP: Voltage-gated ion channels / Transient receptor potential cation channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: TRPC6
    Transient Receptor Potential channels

    Selected InterPro protein domains (see all 7):
     IPR002153 TRPC_channel
     IPR005821 Ion_trans_dom
     IPR004729 TRP_channel
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y210

    ProtoNet protein and cluster: Q9Y210

    4 Blocks protein domains:
    IPB002110 Ankyrin repeat signature
    IPB002153 Transient receptor potential family signature
    IPB005462 Transient receptor potential channel 6 signature
    IPB013555 Transient receptor ion channel II


    UniProtKB/Swiss-Prot: TRPC6_HUMAN, Q9Y210
    Similarity: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily
    Similarity: Contains 4 ANK repeats


    Find genes that share domains with TRPC6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRPC6_HUMAN, Q9Y210
    Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated
    by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled
    receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C.
    Seems not to be activated by intracellular calcium store depletion

         Genatlas biochemistry entry for TRPC6:
    transient receptor potential non voltage channel 6,Drosophila store-operated channel (SOC),predominantly expressed
    in the lung,involved in CA2+ entry stimulated by a G protein coupled receptor from extracellular space by a
    process called calcium capacitative entry (CCE)

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005261cation channel activity ----
    GO:0005262calcium channel activity ----
    GO:0005488binding ----
    GO:0005515protein binding IPI15757897
         
    Find genes that share ontologies with TRPC6           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Trpc6):
     behavior/neurological  cardiovascular system  integument  muscle  nervous system 
     vision/eye 

    Find genes that share phenotypes with TRPC6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Trpc6tm1Lbi for TRPC6

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRPC6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRPC6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRPC6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRPC6

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRPC6:
    hsa-mir-124-3p (MIRT022827)

    Block miRNA regulation of human, mouse, rat TRPC6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRPC6 (see all 15):
    hsa-miR-29c hsa-miR-29a hsa-miR-578 hsa-miR-218 hsa-miR-519e* hsa-miR-1297 hsa-miR-33a* hsa-miR-515-5p
    SwitchGear 3'UTR luciferase reporter plasmidTRPC6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRPC6
    Predesigned siRNA for gene silencing in human, mouse, rat TRPC6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRPC6

    Clone
    Products:
         
    OriGene clones in human, mouse for TRPC6 (see all 8)
    OriGene ORF clones in mouse, rat for TRPC6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRPC6 (NM_004621)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRPC6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPC6

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TRPC6
    Browse ESI BIO Cell Lines and PureStem Progenitors for TRPC6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TRPC6_HUMAN, Q9Y210: Membrane; Multi-pass membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton2
    endoplasmic reticulum2
    extracellular2
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0036057slit diaphragm IEA--

    Find genes that share ontologies with TRPC6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TRPC6 About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Platelet homeostasis
    Platelet homeostasis
    Platelet calcium homeostasis0.00
    Elevation of cytosolic Ca2+ levels0.00
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    5Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58


    Find genes that share SuperPaths with TRPC6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TRPC6
        Intracellular Calcium Signaling

    3 BioSystems Pathways for TRPC6
        Endothelins
    Nephrin/Neph1 signaling in the kidney podocyte
    EPO signaling pathway

    4 Reactome Pathways for TRPC6
        TRP channels
    Effects of PIP2 hydrolysis
    Role of second messengers in netrin-1 signaling
    Elevation of cytosolic Ca2+ levels


        Pathway & Disease-focused RT2 Profiler PCR Array including TRPC6: 
              Neuronal Ion Channels in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TRPC6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRPC6 (Q9Y2101, 3 ENSP000003409134) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MX1P205911, 3, ENSP000003815994EBI-929362,EBI-929476 I2D: score=3 STRING: ENSP00000381599
    FYNP062413, ENSP000003576564I2D: score=2 STRING: ENSP00000357656
    NPHS1O605003, ENSP000003681904I2D: score=1 STRING: ENSP00000368190
    NPHS2Q9NP853, ENSP000003565874I2D: score=1 STRING: ENSP00000356587
    ORAI1Q96D313, ENSP000003282164I2D: score=1 STRING: ENSP00000328216
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0006812cation transport TAS9930701
    GO:0007204positive regulation of cytosolic calcium ion concentration IEA--
    GO:0007411axon guidance TAS--
    GO:0007568aging IEA--

    Find genes that share ontologies with TRPC6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRPC6

    Selected HMDB Compounds for TRPC6 (see all 844)    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----

    Selected IUPHAR Ligands for TRPC6 (TRPC6) (see all 19)    About this table
    LigandTypeActionAffinityPubmed IDs
    La3+
    Channel blockerNone5.22--
    SKF96365
    Channel blockerNone5.22--
    20-HETE
    ActivatorNone5.22--
    ML9
    Channel blockerNone5.22--
    flufenamate
    ActivatorNone5.22--
    ACAA
    Channel blockerNone5.22--
    hyperforin
    ActivatorNone5.2217666455
    GsMTx-4
    Channel blockerNone5.22--
    arachidonic acid
    ActivatorNone5.22--
    KB-R7943
    Channel blockerNone5.22--

    10 Novoseek inferred chemical compound relationships for TRPC6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2-aminoethoxydiphenylborane 90.6 2 20068131 (1), 17351372 (1)
    skf 96365 87 1 15362854 (1)
    1-oleoyl-2-acetyl-sn-glycerol 80.8 7 15601622 (2), 15362854 (1), 17351372 (1)
    flufenamic acid 63.8 9 19232718 (4), 14551041 (1)
    thapsigargin 61.6 4 12736151 (1), 18436303 (1)
    calcium 59.9 31 16204251 (4), 18800249 (4), 17459670 (2), 18506892 (2) (see all 16)
    inositol 1,4,5 trisphosphate 45.3 4 15104177 (1), 15601622 (1), 15104179 (1)
    phosphatidylinositol 29.5 3 15362854 (1), 19129465 (1)
    phenylephrine 9.54 1 14640978 (1)
    lipid 0 2 16270640 (1)



    Find genes that share compounds with TRPC6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TRPC6 gene: 
    NM_004621.5  

    Unigene Cluster for TRPC6:

    Transient receptor potential cation channel, subfamily C, member 6
    Hs.159003  [show with all ESTs]
    Unigene Representative Sequence: NM_004621
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344327(uc001pgk.4 uc009ywy.3 uc009ywz.1) ENST00000532133
    ENST00000348423 ENST00000360497 ENST00000532184 ENST00000527240 ENST00000526713

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TRPC6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRPC6 (see all 15):
    hsa-miR-29c hsa-miR-29a hsa-miR-578 hsa-miR-218 hsa-miR-519e* hsa-miR-1297 hsa-miR-33a* hsa-miR-515-5p
    SwitchGear 3'UTR luciferase reporter plasmidTRPC6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TRPC6
    Predesigned siRNA for gene silencing in human, mouse, rat TRPC6
    Clone
    Products:
         
    OriGene clones in human, mouse for TRPC6 (see all 8)
    OriGene ORF clones in mouse, rat for TRPC6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRPC6 (NM_004621)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRPC6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPC6
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TRPC6
    OriGene qSTAR qPCR primer pairs in human, mouse for TRPC6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRPC6
      QuantiTect SYBR Green Assays in human, mouse, rat TRPC6
      QuantiFast Probe-based Assays in human, mouse, rat TRPC6

    Additional mRNA sequence: 

    AF080394.2 AF086426.1 AJ006276.1 AJ007018.1 AJ271066.1 AJ271067.1 AJ271068.1 AK001960.1 
    AK027769.1 BC093658.1 BC093660.1 

    2 DOTS entries:

    DT.65286058  DT.91757126 

    Selected AceView cDNA sequences (see all 27):

    AF080394 AI381238 AJ271066 BM724871 BI771648 CA312768 AJ271067 AU136989 
    AJ006276 AA633029 AJ007018 BI771244 AJ271068 BX098806 AF086426 BU741499 
    NM_004621 AK001960 AK027769 AI658667 BF001360 W79774 AU156966 W79110 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TRPC6    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
    SP1:                                                                    -                 -               
    SP2:                    -     -                                         -                 -               
    SP3:                          -                                         -                                 
    SP4:                                                                                                      


    ECgene alternative splicing isoforms for TRPC6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TRPC6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAGTGGTG
    TRPC6 Expression
    About this image


    TRPC6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Liver Bud
             Liver Lobule
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    TRPC6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRPC6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.159003

    UniProtKB/Swiss-Prot: TRPC6_HUMAN, Q9Y210
    Tissue specificity: Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in
    podocytes and is a component of the glomerular slit diaphragm

        Pathway & Disease-focused RT2 Profiler PCR Array including TRPC6: 
              Neuronal Ion Channels in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TRPC6
    OriGene qSTAR qPCR primer pairs in human, mouse for TRPC6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRPC6
    QuantiTect SYBR Green Assays in human, mouse, rat TRPC6
    QuantiFast Probe-based Assays in human, mouse, rat TRPC6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for TRPC6 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trpc61 , 5 transient receptor potential cation channel, subfamily more1, 5 88.35(n)1
    93.66(a)1
      9 (2.46 cM)5
    220681  NM_013838.21  NP_038866.21 
     85441965 
    chicken
    (Gallus gallus)
    Aves TRPC61 transient receptor potential cation channel, subfamily more 81.1(n)
    88.48(a)
      418989  XM_003640588.2  XP_003640636.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRPC66
    transient receptor potential cation channel, subfa...
    88(a)
    1 ↔ 1
    3(192700155-192785803)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia trpc61 transient receptor potential cation channel, subfamily more 77.17(n)
    85.2(a)
      100493327  XM_002935570.2  XP_002935616.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003330901 transient receptor potential cation channel, subfamily more 70.51(n)
    79.27(a)
      100333090  XM_002665399.2  XP_002665445.2 
    worm
    (Caenorhabditis elegans)
    Secernentea trp-11 , 3 Transient-receptor-potential (trp)
    protein3
    trp-11
    36(a)3
    51.81(n)1
    41.64(a)1
      III(8607645-8614376)3
    1762021  NM_001047424.21  NP_001040889.11 


    ENSEMBL Gene Tree for TRPC6 (if available)
    TreeFam Gene Tree for TRPC6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TRPC6 gene
    TRPC42  TRPC12  TRPC72  TRPC52  TRPC32  
    6 SIMAP similar genes for TRPC6 using alignment to 2 protein entries:     TRPC6_HUMAN (see all proteins):
    TRPC3    TRPC7    TRP7    TRPC5    TRPC4    TRPC1

    Find genes that share paralogs with TRPC6           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for TRPC6 (see all 11)
    PGOHUM00000242910 PGOHUM00000239435 PGOHUM00000245787 PGOHUM00000235165 PGOHUM00000235416


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TRPC6 (see all 3439)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1214343911,2,,4
    C,FFocal segmental glomerulosclerosis 2 (FSGS2)4 pathogenic1101245345(-) GGCCAA/GTGAGC 2 N S mis11Minor allele frequency- G:0.00NA 4550
    VAR_0267344
    Focal segmental glomerulosclerosis 2 (FSGS2)4--see VAR_0267342 E K mis40--------
    VAR_0267304
    Focal segmental glomerulosclerosis 2 (FSGS2)4--see VAR_0267302 P Q mis40--------
    VAR_0267334
    Focal segmental glomerulosclerosis 2 (FSGS2)4--see VAR_0267332 R C mis40--------
    VAR_0672484
    Focal segmental glomerulosclerosis 2 (FSGS2)4--see VAR_0672482 H L mis40--------
    VAR_0267324
    Focal segmental glomerulosclerosis 2 (FSGS2)4--see VAR_0267322 S T mis40--------
    rs357139491,2
    C--97277762(+) TTATG-/AAAAAA 1 -- int12Minor allele frequency- A:0.00NA CSA 4
    rs755881381,2
    C--97286306(+) ACTTT-/AATCAG 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1995303881,2
    C--97286306(+) ACTTTA/TATCAG 1 -- int10--------
    rs1465473471,2
    C--97289391(+) TGCTA-/TGTGTGT 1 -- int10--------

    HapMap Linkage Disequilibrium report for TRPC6 (101322295 - 101572295 bp, first 250kb of TRPC6)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TRPC6 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671069CNV Deletion23128226
    esv3066CNV Deletion18987735
    esv2104024CNV Deletion18987734
    esv1005678CNV Deletion20482838
    esv2744985CNV Deletion23290073
    esv1637667CNV Deletion17803354
    esv2664051CNV Deletion23128226
    esv2037840CNV Deletion18987734
    esv2666466CNV Deletion23128226
    esv2586580CNV Deletion19546169

    Human Gene Mutation Database (HGMD): TRPC6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRPC6
    DNA2.0 Custom Variant and Variant Library Synthesis for TRPC6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603652   
    OMIM disorders: 603965  
    UniProtKB/Swiss-Prot: TRPC6_HUMAN, Q9Y210
  • Focal segmental glomerulosclerosis 2 (FSGS2) [MIM:603965]: A renal pathology defined by the presence of
    segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive
    decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state
    requiring either dialysis therapy or kidney transplantation. Note=The disease is caused by mutations affecting
    the gene represented in this entry

  • 6 diseases for TRPC6:    
    About MalaCards
    diencephalic neoplasm    focal segmental glomerulosclerosis 2    familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis    glomerulosclerosis
    focal segmental glomerulosclerosis    malignant hypertension

    4 diseases from the University of Copenhagen DISEASES database for TRPC6:
    Focal segmental glomerulosclerosis     Diencephalic neoplasm     Nephrotic syndrome     Prostate cancer

    Find genes that share disorders with TRPC6           About GenesLikeMe

    6 Novoseek inferred disease relationships for TRPC6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glomerulosclerosis, focal segmental 77.5 10 19124028 (2), 19458060 (2), 16290061 (2), 19129465 (1) (see all 6)
    glomerulosclerosis 48.8 1 17459670 (1)
    proteinuria 38.2 2 17167110 (1)
    hypertrophy 28.1 1 17099778 (1)
    renal disease 24.6 1 17167110 (1)
    renal failure 11.9 1 17167110 (1)

    Genetic Association Database (GAD): TRPC6
    Human Genome Epidemiology (HuGE) Navigator: TRPC6 (7 documents)

    Export disorders for TRPC6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TRPC6 gene, integrated from 10 sources (see all 190) (see top 10):
    (articles sorted by number of sources associating them with TRPC6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. (PubMed id 15879175)1, 2, 3, 9 Winn M.P....Rosenberg P.B. (Science 2005)
    2. Identification and assignment of the human transient receptor potential channel 6 gene TRPC6 to chromosome 11q21-22. (PubMed id 9925922)1, 2, 3 D'Esposito M.... Ciccodicola A. (Cytogenet. Cell Genet. 1998)
    3. TRPC6 mutational analysis in a large cohort of patients with focal segmental glomerulosclerosis. (PubMed id 19458060)1, 4, 9 SantA-n S....de los RA-os F.J. (Nephrol. Dial. Transplant. 2009)
    4. N-linked protein glycosylation is a major determinant for basal TRPC3 and TRPC6 channel activity. (PubMed id 12970363)1, 2, 9 Dietrich A....Gudermann T. (J. Biol. Chem. 2003)
    5. TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. (PubMed id 15924139)1, 2, 9 Reiser J.... Pollak M.R. (Nat. Genet. 2005)
    6. Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. (PubMed id 9930701)1, 2, 9 Hofmann T....Schultz G. (Nature 1999)
    7. TRPC6 mutations in children with steroid-resistant nephrotic syndrome and atypical phenotype. (PubMed id 21734084)1, 2 Gigante M.... Gesualdo L. (Clin. J. Am. Soc. Nephrol. 2011)
    8. Lack of association between transient receptor potential cation channel 6 polymorphisms and primary membranous glomerulonephritis. (PubMed id 20540633)1, 4 Chen W.C....Chen Y.H. (Ren Fail 2010)
    9. Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. (PubMed id 20346360)1, 4 Roberts K.E....Fallon M.B. (Gastroenterology 2010)
    10. A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension. (PubMed id 19380626)1, 4 Yu Y....Yuan J.X. (Circulation 2009)
    11. Infantile hypertrophic pyloric stenosis: evaluation of three positional candidate genes, TRPC1, TRPC5 and TRPC6, by association analysis and re-sequencing. (PubMed id 19701773)1, 4 Everett K.V....Chung E.M. (Hum. Genet. 2009)
    12. RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC. (PubMed id 17850865)1, 2 Lussier M.P.... Boulay G. (Cell Calcium 2008)
    13. MxA, a member of the dynamin superfamily, interacts with the ankyrin- like repeat domain of TRPC. (PubMed id 15757897)1, 2 Lussier M.P.... Boulay G. (J. Biol. Chem. 2005)
    14. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. (PubMed id 16382100)1, 3 Clapham D.E....Schultz G. (Pharmacol. Rev. 2005)
    15. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    16. TRP4 (CCE1) protein is part of native calcium release-activated Ca2+- like channels in adrenal cells. (PubMed id 10816590)1, 2 Philipp S....Flockerzi V. (J. Biol. Chem. 2000)
    17. Identification and functional analysis of a novel TRPC6 mutation associated with late onset familial focal segmental glomerulosclerosis in Chinese patients. (PubMed id 19124028)1, 9 Zhu B....Wang W.M. (Mutat. Res. 2009)
    18. Downregulation of TRPC6 protein expression by high glucose, a possible mechanism for the impaired Ca2+ signaling in glomerular mesangial cells in diabetes. (PubMed id 17699555)1, 9 Graham S....Ma R. (Am. J. Physiol. Renal Physiol. 2007)
    19. The canonical transient receptor potential 6 channel as a putative phosphatidylinositol 3,4,5-trisphosphate-sensitive calcium entry system. (PubMed id 15362854)1, 9 Tseng P.H....Chen C.S. (Biochemistry 2004)
    20. TRPC6 mutations associated with focal segmental glomerulosclerosis cause constitutive activation of NFAT-dependent transcription. (PubMed id 19129465)1, 9 SchlAPndorff J....Pollak M.R. (Am. J. Physiol., Cell Physiol. 2009)
    21. Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation Novel mechanism of cardiac stress modulation by PDE5 inhibition. (PubMed id 19961855)1, 9 Koitabashi N....Kass D.A. (J. Mol. Cell. Cardiol. 2010)
    22. Canonical transient receptor potential channel (TRPC)3 and TRPC6 associate with large-conductance Ca2+-activated K+ (BKCa) channels: role in BKCa trafficking to the surface of cultured podocytes. (PubMed id 19052171)1, 9 Kim E.Y....Dryer S.E. (Mol. Pharmacol. 2009)
    23. Regulation of TRPC6 channel activity by tyrosine phosphorylation. (PubMed id 14761972)1, 9 Hisatsune C.... Mikoshiba K. (J. Biol. Chem. 2004)
    24. Capacitative calcium entry and transient receptor potential canonical 6 expression control human hepatoma cell proliferation. (PubMed id 18506892)1, 9 El Boustany C....Capiod T. (Hepatology 2008)
    25. VEGF-mediated elevated intracellular calcium and angiogenesis in human microvascular endothelial cells in vitro are inhibited by dominant negative TRPC6. (PubMed id 18800249)1, 9 Hamdollah Zadeh M.A....Bates D.O. (Microcirculation 2008)
    26. Heteromultimeric TRPC6-TRPC7 channels contribute to arginine vasopressin-induced cation current of A7r5 vascular smooth muscle cells. (PubMed id 16690880)1, 9 Maruyama Y....Cole W.C. (Circ. Res. 2006)
    27. Blockade of TRPC6 channels induced G2/M phase arrest and suppressed growth in human gastric cancer cells. (PubMed id 19610066)1, 9 Cai R....Wang Y. (Int. J. Cancer 2009)
    28. Diacylglycerol activates the influx of extracellular cations in T-lymphocytes independently of intracellular calcium-store depletion and possibly involving endogenous TRP6 gene products. (PubMed id 11988098)1, 9 Gamberucci A....Benedetti A. (Biochem. J. 2002)
    29. [Mechanism of cardiac hypertrophy via diacylglycerol-sensitive TRPC channels]. (PubMed id 20190513)1, 9 Nishida M....Kurose H. (Yakugaku Zasshi 2010)
    30. TRPC6 contributes to the Ca(2+) leak of human erythrocytes. (PubMed id 18209485)1, 9 Foller M....Huber S.M. (Cell. Physiol. Biochem. 2008)
    31. Store-operated Ca2+ channels formed by TRPC1, TRPC6 and Orai1 and non-store-operated channels formed by TRPC3 are involved in the regulation of NADPH oxidase in HL-60 granulocytes. (PubMed id 18436303)1, 9 BrAcchard S....Tschirhart E.J. (Cell Calcium 2008)
    32. Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension. (PubMed id 15358862)1, 9 Yu Y....Yuan J.X. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    33. Attenuation of canonical transient receptor potential-like channel 6 expression specifically reduces the diacylglycerol-mediated increase in intracellular calcium in human myometrial cells. (PubMed id 19940041)1, 9 Chung D....Sanborn B.M. (Endocrinology 2010)
    34. High glucose enhances transient receptor potential channel canonical type 6-dependent calcium influx in human platelets via phosphatidylinositol 3-kinase-dependent pathway. (PubMed id 18258814)1, 9 Liu D....Tepel M. (Arterioscler. Thromb. Vasc. Biol. 2008)
    35. Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces the change of calcium mobilization via TRPC ion channels in cultured human corporal smooth muscle cells. (PubMed id 16034470)1, 9 So I....Lee S.W. (Int. J. Impot. Res. 2005)
    36. Store-operated Ca2+ entry in first trimester and term human placenta. (PubMed id 12766233)1, 9 Clarson L.H....Powell T. (J. Physiol. (Lond.) 2003)
    37. mRNA distribution analysis of human TRPC family in CNS and peripheral tissues. (PubMed id 12531519)1, 9 Riccio A....Pangalos M.N. (Brain Res. Mol. Brain Res. 2002)
    38. Molecular identification and localization of Trp homologues, putative calcium channels, in pregnant human uterus. (PubMed id 12356946)1, 9 Dalrymple A....Tribe R.M. (Mol. Hum. Reprod. 2002)
    39. Expression of transient receptor potential C6 and related transient receptor potential family members in human airway smooth muscle and lung tissue. (PubMed id 12871853)1, 9 Corteling R.L....Hall I.P. (Am. J. Respir. Cell Mol. Biol. 2004)
    40. Enhanced capacitative calcium entry and TRPC channel gene expression in human LES smooth muscle. (PubMed id 12736151)1, 9 Wang J....Preiksaitis H.G. (Am. J. Physiol. Gastrointest. Liver Physiol. 2003)
    41. Identification of TRPC6 as a possible candidate target gene within an amplicon at 11q21-q22.2 for migratory capacity in head and neck squamous cell carcinomas. (PubMed id 23497198)1 Bernaldo de QuirA^s S....Chiara M.D. (BMC Cancer 2013)
    42. Gain-of-function mutations in transient receptor potential C6 (TRPC6) activate extracellular signal-regulated kinases 1/2 (ERK1/2). (PubMed id 23645677)1 Chiluiza D....SchlAPndorff J. (J. Biol. Chem. 2013)
    43. Pdx-1 activates islet I+- and I^-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2. (PubMed id 23938296)1 Hayes H.L....Hohmeier H.E. (Mol. Cell. Biol. 2013)
    44. Characterization of the S100A1 protein binding site on TRPC6 C-terminus. (PubMed id 23671622)1 Bily J....Teisinger J. (PLoS ONE 2013)
    45. Nuclear factor I_B mediates suppression of canonical transient receptor potential 6 expression by reactive oxygen species and protein kinase C in kidney cells. (PubMed id 23525112)1 Wang Y....Ma R. (J. Biol. Chem. 2013)
    46. TRPC6 regulates CXCR2-mediated chemotaxis of murine neutrophils. (PubMed id 23636057)1 Lindemann O....Schwab A. (J. Immunol. 2013)
    47. New TRPC6 gain-of-function mutation in a non-consanguineous Dutch family with late-onset focal segmental glomerulosclerosis. (PubMed id 23291369)1 Hofstra J.M....Nijenhuis T. (Nephrol. Dial. Transplant. 2013)
    48. Atrial natriuretic peptide-mediated inhibition of microcirculatory endothelial Ca2+ and permeability response to histamine involves cGMP-dependent protein kinase I and TRPC6 channels. (PubMed id 23814119)1 Chen W....Kuhn M. (Arterioscler. Thromb. Vasc. Biol. 2013)
    49. High glucose-induced apoptosis in cultured podocytes involves TRPC6-dependent calcium entry via the RhoA/ROCK pathway. (PubMed id 23570668)1 Yang H....Jiao J. (Biochem. Biophys. Res. Commun. 2013)
    50. Critical role of TRPC6 channels in the development of human renal cell carcinoma. (PubMed id 23700295)1 Song J....Yue D. (Mol. Biol. Rep. 2013)
    51. Increased expression of the transient receptor potential cation channel 6 gene in patients with primary open-angle glaucoma. (PubMed id 23566105)1 Chen S....Zhang X. (amp 2013)
    52. Screening of ACTN4 and TRPC6 mutations in a Chinese cohort of patients with adult-onset familial focal segmental glomerulosclerosis. (PubMed id 23689571)1 Zhang Q....Chen N. (Contrib Nephrol 2013)
    53. A novel TRPC6 mutation in a family with podocytopathy and clinical variability. (PubMed id 23663351)1 Mottl A.K....Weck K.E. (BMC Nephrol 2013)
    54. TRPC6 gene variants in Czech adult patients with focal segmental glomerulosclerosis and minimal change disease. (PubMed id 22980509)1 ObeidovA! L....TesaA9 V. (Folia Biol. (Praha) 2012)
    55. Pulsatile atheroprone shear stress affects the expression of transient receptor potential channels in human endothelial cells. (PubMed id 22566504)1 Thilo F....Tepel M. (Hypertension 2012)
    56. Diacylglycerol-containing oleic acid induces increases in [Ca(2+)](i) via TRPC3/6 channels in human T-cells. (PubMed id 22306362)1 Carrillo C....Khan N.A. (Biochim. Biophys. Acta 2012)
    57. The upregulation of TRPC6 contributes to CaA^a8_ signaling and actin assembly in human mesangial cells after chronic hypoxia. (PubMed id 22554521)1 Liao C....Jiao J. (Biochem. Biophys. Res. Commun. 2012)
    58. The possible role of TRPC6 in atopic dermatitis. (PubMed id 22000711)1 Sun X.D....Gao X.H. (Med. Hypotheses 2012)
    59. Do cysteine residues regulate transient receptor potential canonical type 6 channel protein expression? (PubMed id 22004559)1 Thilo F....Tepel M. (amp 2012)
    60. TRPC6 gene variants in Turkish children with steroid-resistant nephrotic syndrome. (PubMed id 21511817)1 Mir S....Sozeri B. (Nephrol. Dial. Transplant. 2012)
    61. [Essential role of TRPC6 in the proliferation of gastric cancer and its mechanism]. (PubMed id 23158989)1 Cai R....Jin Y.N. (Zhonghua Zhong Liu Za Zhi 2012)
    62. Involvement of phosphoinositide 3-kinase and PTEN protein in mechanism of activation of TRPC6 protein in vascular smooth muscle cells. (PubMed id 22493444)1 Monet M....Boulay G. (J. Biol. Chem. 2012)
    63. Cilostazol suppresses angiotensin II-induced vasoconstriction via protein kinase A-mediated phosphorylation of the transient receptor potential canonical 6 channel. (PubMed id 21799177)1 Nishioka K....Kurose H. (Arterioscler. Thromb. Vasc. Biol. 2011)
    64. cAMP activates TRPC6 channels via the phosphatidylinositol 3-kinase (PI3K)-protein kinase B (PKB)-mitogen-activated protein kinase kinase (MEK)-ERK1/2 signaling pathway. (PubMed id 21487005)1 Shen B....Yao X. (J. Biol. Chem. 2011)
    65. No association between the SNPs (rs56134796; rs3824934; rs41302375) in the TRPC6 gene promoter and infantile hypertrophic pyloric stenosis in Chinese people. (PubMed id 21822655)1 Ju J.J....Yuan Z.W. (Pediatr. Surg. Int. 2011)
    66. The transient receptor potential (TRP) channel TRPC3 TRP domain and AMP-activated protein kinase binding site are required for TRPC3 activation by erythropoietin. (PubMed id 21757714)1 Hirschler-Laszkiewicz I....Miller B.A. (J. Biol. Chem. 2011)
    67. Abundance of TRPC6 protein in glomerular mesangial cells is decreased by ROS and PKC in diabetes. (PubMed id 21525431)1 Graham S....Ma R. (Am. J. Physiol., Cell Physiol. 2011)
    68. Balancing calcium signals through TRPC5 and TRPC6 in podocytes. (PubMed id 21980113)1 Greka A. and Mundel P. (J. Am. Soc. Nephrol. 2011)
    69. Tyrosine phosphorylation-dependent activation of TRPC6 regulated by PLC-I^1 and nephrin: effect of mutations associated with focal segmental glomerulosclerosis. (PubMed id 21471003)1 Kanda S....Hattori S. (Mol. Biol. Cell 2011)
    70. Transient receptor potential canonical channel 6 links Ca2+ mishandling to cystic fibrosis transmembrane conductance regulator channel dysfunction in cystic fibrosis. (PubMed id 20203293)1 Antigny F....Vandebrouck C. (Am. J. Respir. Cell Mol. Biol. 2011)
    71. Functional role of the calmodulin- and inositol 1,4,5-trisphosphate receptor-binding (CIRB) site of TRPC6 in human platelet activation. (PubMed id 21757000)1 Dionisio N....Rosado J.A. (Cell. Signal. 2011)
    72. The over-expression of TRPC6 channels in HEK-293 cells favours the intracellular accumulation of zinc. (PubMed id 21864503)1 Gibon J....Bouron A. (Biochim. Biophys. Acta 2011)
    73. A three-stage genome-wide association study of general cognitive ability: hunting the small effects. (PubMed id 20306291)1 Davis O.S....Plomin R. (Behav. Genet. 2010)
    74. Expression of transient receptor potential C6 channels in human lung macrophages. (PubMed id 19843708)1 Finney-Hayward T.K....Donnelly L.E. (Am. J. Respir. Cell Mol. Biol. 2010)
    75. A new role for PTEN in regulating transient receptor potential canonical channel 6-mediated Ca2+ entry, endothelial permeability, and angiogenesis. (PubMed id 20705603)1 Kini V....Mehta D. (J. Biol. Chem. 2010)
    76. Protein kinase C-dependent phosphorylation of transient receptor potential canonical 6 (TRPC6) on serine 448 causes channel inhibition. (PubMed id 20961851)1 Bousquet S.M....Boulay G. (J. Biol. Chem. 2010)
    77. A role for receptor-operated Ca2+ entry in human pulmonary artery smooth muscle cells in response to hypoxia. (PubMed id 20533864)1 Tang C....Gu Y. (Physiol Res 2010)
    78. Receptor channel TRPC6 is a key mediator of Notch-driven glioblastoma growth and invasiveness. (PubMed id 20028870)1 Chigurupati S....Chan S.L. (Cancer Res. 2010)
    79. Involvement of Rab9 and Rab11 in the intracellular trafficking of TRPC6. (PubMed id 20346379)1 Cayouette S....Boulay G. (Biochim. Biophys. Acta 2010)
    80. The role of TRPC6 in HGF-induced cell proliferation of human prostate cancer DU145 and PC3 cells. (PubMed id 20835261)1 Wang Y....Wang P. (Asian J. Androl. 2010)
    81. Selective interference with TRPC3/6 channels disrupts OX1 receptor signalling via NCX and reveals a distinct calcium influx pathway. (PubMed id 20728215)1 Louhivuori L.M....Akerman K.E. (Cell Calcium 2010)
    82. Renal TRPathies. (PubMed id 20395377)1 Dietrich A....Gudermann T. (J. Am. Soc. Nephrol. 2010)
    83. Essential role of TRPC6 channels in G2/M phase transition and development of human glioma. (PubMed id 20554944)1 Ding X....Wang Y. (J. Natl. Cancer Inst. 2010)
    84. TRPC3 activation by erythropoietin is modulated by TRPC6. (PubMed id 19074769)1 Hirschler-Laszkiewicz I....Miller B.A. (J. Biol. Chem. 2009)
    85. A novel TRPC6 mutation that causes childhood FSGS. (PubMed id 19936226)1 Heeringa S.F....Hildebrandt F. (PLoS ONE 2009)
    86. Regulation of cardiac hypertrophy by the formation of G protein-coupled receptor--TRPC channel protein complex. (PubMed id 19749484)1 Nishida M....Kurose H. (Nippon Yakurigaku Zasshi 2009)
    87. Dynamic interaction of hTRPC6 with the Orai1-STIM1 complex or hTRPC3 mediates its role in capacitative or non-capacitative Ca(2+) entry pathways. (PubMed id 19260825)1 Jardin I....Rosado J.A. (Biochem. J. 2009)
    88. Evidence for inflammatory signaling in idiopathic pulmonary artery hypertension: TRPC6 and nuclear factor-kappaB. (PubMed id 19414653)1 Hamid R. and Newman J.H. (Circulation 2009)
    89. Sensitizing the Slit Diaphragm with TRPC6 ion channels. (PubMed id 18784209)1 MAPller C.C....Reiser J. (J. Am. Soc. Nephrol. 2009)
    90. Expression of TRPC6 in benign and malignant human prostate tissues. (PubMed id 19701218)1 Yue D....Ren C.S. (Asian J. Androl. 2009)
    91. Critical role of TRPC6 channels in VEGF-mediated angiogenesis. (PubMed id 19394138)1 Ge R....Wang Y. (Cancer Lett. 2009)
    92. Synergistic activation of vascular TRPC6 channel by receptor and mechanical stimulation via phospholipase C/diacylglycerol and phospholipase A2/omega-hydroxylase/20-HETE pathways. (PubMed id 19443836)1 Inoue R....Ito Y. (Circ. Res. 2009)
    93. Revisiting TRPC1 and TRPC6 mechanosensitivity. (PubMed id 17957383)1 Gottlieb P....HonorAc E. (Pflugers Arch. 2008)
    94. Elucidation of a TRPC6-TRPC5 channel cascade that restricts endothelial cell movement. (PubMed id 18495872)1 Chaudhuri P....Graham L.M. (Mol. Biol. Cell 2008)
    95. Phosphoproteome of resting human platelets. (PubMed id 18088087)2 Zahedi R.P.... Sickmann A. (J. Proteome Res. 2008)
    96. Specific TRPC6 channel activation, a novel approach to stimulate keratinocyte differentiation. (PubMed id 18818211)1 MA1ller M....Leuner K. (J. Biol. Chem. 2008)
    97. Phosphatidylinositol 4,5-bisphosphate enhances store-operated calcium entry through hTRPC6 channel in human platelets. (PubMed id 17719101)1 JardA-n I....Rosado J.A. (Biochim. Biophys. Acta 2008)
    98. Nitric oxide-cGMP-protein kinase G pathway negatively regulates vascular transient receptor potential channel TRPC6. (PubMed id 18617565)1 Takahashi S....Inoue R. (J. Physiol. (Lond.) 2008)
    99. Snapin, a new regulator of receptor signaling, augments alpha1A-adrenoceptor-operated calcium influx through TRPC6. (PubMed id 17684020)1 Suzuki F....Muramatsu I. (J. Biol. Chem. 2007)
    100. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (BMC Med. Genet. 2007)
    101. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)4 Yang Q....O'Donnell C.J. (BMC Med. Genet. 2007)
    102. Integration of phosphoinositide- and calmodulin-mediated regulation of TRPC6. (PubMed id 17317623)1 Kwon Y....Montell C. (Mol. Cell 2007)
    103. TRPC6. (PubMed id 17217054)1 Dietrich A. and Gudermann T. (Handb Exp Pharmacol 2007)
    104. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (BMC Med. Genet. 2007)
    105. Galphaq-TRPC6-mediated Ca2+ entry induces RhoA activation and resultant endothelial cell shape change in response to thrombin. (PubMed id 17197445)1 Singh I....Mehta D. (J. Biol. Chem. 2007)
    106. Orai proteins interact with TRPC channels and confer responsiveness to store depletion. (PubMed id 17360584)1 Liao Y....Birnbaumer L. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    107. Transient receptor potential channel 6-mediated, localized cytosolic [Na+] transients drive Na+/Ca2+ exchanger-mediated Ca2+ entry in purinergically stimulated aorta smooth muscle cells. (PubMed id 17872462)1 Poburko D....van Breemen C. (Circ. Res. 2007)
    108. Expression of transient receptor channel proteins in human fundal myometrium in pregnancy. (PubMed id 16527499)1 Ku C.Y....Sanborn B.M. (J. Soc. Gynecol. Investig. 2006)
    109. TRPC6 in glomerular health and disease: what we know and what we believe. (PubMed id 17116414)1 SchlAPndorff J.S. and Pollak M.R. (amp 2006)
    110. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (Cell 2006)
    111. Human TRPC6 expressed in HEK 293 cells forms non-selective cation channels with limited Ca2+ permeability. (PubMed id 16439426)1 Estacion M....Schilling W.P. (J. Physiol. (Lond.) 2006)
    112. Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx. (PubMed id 15623527)1 Bandyopadhyay B.C....Ambudkar I.S. (J. Biol. Chem. 2005)
    113. Slit or pore? A mutation of the ion channel TRPC6 causes FSGS. (PubMed id 15998650)1 Walz G. (Nephrol. Dial. Transplant. 2005)
    114. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    115. Exocytotic insertion of TRPC6 channel into the plasma membrane upon Gq protein-coupled receptor activation. (PubMed id 14662757)1 Cayouette S....Boulay G. (J. Biol. Chem. 2004)
    116. Interaction of TRPC2 and TRPC6 in erythropoietin modulation of calcium influx. (PubMed id 14699131)1 Chu X....Miller B.A. (J. Biol. Chem. 2004)
    117. Activation of human TRPC6 channels by receptor stimulation. (PubMed id 15023993)1 Estacion M....Schilling W.P. (J. Biol. Chem. 2004)
    118. Cytoskeletal reorganization internalizes multiple transient receptor potential channels and blocks calcium entry into human neutrophils. (PubMed id 14688372)1 Itagaki K....Hauser C.J. (J. Immunol. 2004)
    119. Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. (PubMed id 14505576)1 Yuan J.P....Worley P.F. (Cell 2003)
    120. Role and regulation of TRP channels in neutrophil granulocytes. (PubMed id 12765698)1 Heiner I....LA1ckhoff A. (Cell Calcium 2003)
    121. Expression profile of the transient receptor potential (TRP) family in neutrophil granulocytes: evidence for currents through long TRP channel 2 induced by ADP-ribose and NAD. (PubMed id 12564954)1 Heiner I....LA1ckhoff A. (Biochem. J. 2003)
    122. Formation of novel TRPC channels by complex subunit interactions in embryonic brain. (PubMed id 12857742)1 StrA1bing C....Clapham D.E. (J. Biol. Chem. 2003)
    123. Subunit composition of mammalian transient receptor potential channels in living cells. (PubMed id 12032305)1 Hofmann T.... Gudermann T. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    124. Selective association of TRPC channel subunits in rat brain synaptosomes. (PubMed id 12377790)1 Goel M....Schilling W.P. (J. Biol. Chem. 2002)
    125. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    126. Expression and role of TRPC proteins in human platelets: evidence that TRPC6 forms the store-independent calcium entry channel. (PubMed id 12351388)1 Hassock S.R....Authi K.S. (Blood 2002)
    127. Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels. (PubMed id 11290752)1 Tang J....Zhu M.X. (J. Biol. Chem. 2001)
    128. Cloning, expression and subcellular localization of two novel splice variants of mouse transient receptor potential channel 2. (PubMed id 10998353)1 Hofmann T....Gudermann T. (Biochem. J. 2000)
    129. Modulation of Ca(2+) entry by polypeptides of the inositol 1,4, 5- trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca(2+) entry. (PubMed id 10611319)1 Boulay G.... Birnbaumer L. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    130. Linkage of a gene causing familial focal segmental glomerulosclerosis to chromosome 11 and further evidence of genetic heterogeneity. (PubMed id 10368108)1 Winn M.P....Vance J.M. (Genomics 1999)
    131. Effects of siRNA knock-down of TRPC6 and InsP(3)R1 in vasopressin-induced Ca(2+) oscillations of A7r5 vascular smooth muscle cells. (PubMed id 18835357)9 Li M....Wier W.G. (Pharmacol. Res. 2008)
    132. Role of endogenous TRPC6 channels in Ca2+ signal generation in A7r5 smooth muscle cells. (PubMed id 16204251)9 Soboloff J....Gill D.L. (J. Biol. Chem. 2005)
    133. Abnormal expression, localization and interaction of canonical transient receptor potential ion channels in human breast cancer cell lines and tissues: a potential target for breast cancer diagnosis and therapy. (PubMed id 19689790)9 Aydar E....Palmer C. (Cancer Cell Int. 2009)
    134. Induction of TRPC6 channel in acquired forms of proteinuric kidney disease. (PubMed id 17167110)9 MAPller C.C....Reiser J. (J. Am. Soc. Nephrol. 2007)
    135. Role of transient receptor potential canonical 6 (TRPC6) in non-transferrin-bound iron uptake in neuronal phenotype PC12 cells. (PubMed id 14640978)9 Mwanjewe J. and Grover A.K. (Biochem. J. 2004)
    136. PDGF stimulates pulmonary vascular smooth muscle cell proliferation by upregulating TRPC6 expression. (PubMed id 12529250)9 Yu Y....Yuan J.X. (Am. J. Physiol., Cell Physiol. 2003)
    137. TRPC6 and FSGS: the latest TRP channelopathy. (PubMed id 17459670)9 Mukerji N....Winn M.P. (Biochim. Biophys. Acta 2007)
    138. The overexpression of presenilin2 and Alzheimer's-disease-linked presenilin2 variants influences TRPC6-enhanced Ca2+ entry into HEK293 cells. (PubMed id 15601622)9 Lessard C.B....Boulay G. (Cell. Signal. 2005)
    139. TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling. (PubMed id 17099778)9 Kuwahara K....Olson E.N. (J. Clin. Invest. 2006)
    140. Flufenamic acid is a tool for investigating TRPC6-mediated calcium signalling in human conditionally immortalised podocytes and HEK293 cells. (PubMed id 19232718)9 Foster R.R....Saleem M.A. (Cell Calcium 2009)
    141. Expression of TRPC6 channels in human epithelial breast cancer cells. (PubMed id 18452628)9 Guilbert A....Ouadid-Ahidouch H. (BMC Cancer 2008)
    142. Ca(2+)-calmodulin regulates receptor-operated Ca(2+) entry activity of TRPC6 in HEK-293 cells. (PubMed id 12379180)9 Boulay G. (Cell Calcium 2002)
    143. Isoform-selective physical coupling of TRPC3 channels to IP3 receptors in smooth muscle cells regulates arterial contractility. (PubMed id 20378853)9 Adebiyi A....Jaggar J.H. (Circ. Res. 2010)
    144. High glucose-induced oxidative stress increases transient receptor potential channel expression in human monocytes. (PubMed id 20068131)9 Wuensch T....Tepel M. (Diabetes 2010)
    145. Identification of two domains involved in the assembly of transient receptor potential canonical channels. (PubMed id 16916799)9 Lepage P.K....Boulay G. (J. Biol. Chem. 2006)
    146. Transient receptor potential protein subunit assembly and membrane distribution in human platelets. (PubMed id 16270640)9 Brownlow S.L. and Sage S.O. (Thromb. Haemost. 2005)
    147. Bosentan inhibits transient receptor potential channel expression in pulmonary vascular myocytes. (PubMed id 15317671)9 Kunichika N....Yuan J.X. (Am. J. Respir. Crit. Care Med. 2004)
    148. Activation, subunit composition and physiological relevance of DAG-sensitive TRPC proteins. (PubMed id 15104178)9 Gudermann T....Dietrich A. (Novartis Found. Symp. 2004)
    149. Evidence of a role for TRPC channels in VEGF-mediated increased vascular permeability in vivo. (PubMed id 14551041)9 Pocock T.M....Bates D.O. (Am. J. Physiol. Heart Circ. Physiol. 2004)
    150. A diacylglycerol-activated Ca2+ channel in PC12 cells (an adrenal chromaffin cell line) correlates with expression of the TRP-6 (transient receptor potential) protein. (PubMed id 11535132)9 Tesfai Y....Barritt G.J. (Biochem. J. 2001)
    151. Increased store-operated and 1-oleoyl-2-acetyl-sn-glycerol-induced calcium influx in monocytes is mediated by transient receptor potential canonical channels in human essential hypertension. (PubMed id 17351372)9 Liu D.Y....Tepel M. (J. Hypertens. 2007)
    152. Plasticity of TRPC expression in arterial smooth muscle: correlation with store-operated Ca2+ entry. (PubMed id 15561760)9 Bergdahl A....Hellstrand P. (Am. J. Physiol., Cell Physiol. 2005)
    153. TRPC6 - a new podocyte gene involved in focal segmental glomerulosclerosis. (PubMed id 16290061)9 Kriz W. (Trends Mol Med 2005)
    154. Signalling mechanisms for TRPC3 channels. (PubMed id 15104179)9 Putney J.W....Bird G.S. (Novartis Found. Symp. 2004)
    155. Critical role of TRPC6 channels in G2 phase transition and the development of human oesophageal cancer. (PubMed id 19651628)9 Shi Y....Wang Y.Z. (Gut 2009)
    156. TRPC channels function independently of STIM1 and Orai1. (PubMed id 19332491)9 DeHaven W.I....Putney J.W. (J. Physiol. (Lond.) 2009)
    157. Increased TRPC3 expression in vascular endothelium of patients with malignant hypertension. (PubMed id 19136933)9 Thilo F....Tepel M. (Mod. Pathol. 2009)
    158. R168H and V165X mutant podocin might induce different degrees of podocyte injury via different molecular mechanisms. (PubMed id 19674119)9 Fan Q....Guan N. (amp 2009)
    159. (Endo)cannabinoids mediate different Ca2+ entry mechanisms in human bronchial epithelial cells. (PubMed id 19255745)9 Gkoumassi E....Zaagsma J. (Naunyn Schmiedebergs Arch. Pharmacol. 2009)
    160. 2007 Young Investigator Award: TRP'ing into a new era for glomerular disease. (PubMed id 18434567)9 Winn M.P. (J. Am. Soc. Nephrol. 2008)
    161. Differences in STIM1 and TRPC expression in proximal and distal pulmonary arterial smooth muscle are associated with differences in Ca2+ responses to hypoxia. (PubMed id 18424621)9 Lu W....Sylvester J.T. (Am. J. Physiol. Lung Cell Mol. Physiol. 2008)
    162. Bigenic heterozygosity and the development of steroid-resistant focal segmental glomerulosclerosis. (PubMed id 18443213)9 LAPwik M....van den Heuvel L. (Nephrol. Dial. Transplant. 2008)
    163. Expression profiling and electrophysiological studies suggest a major role for Orai1 in the store-operated Ca2+ influx pathway of platelets and megakaryocytes. (PubMed id 18569867)9 Tolhurst G....Mahaut-Smith M.P. (Platelets 2008)
    164. Genetic basis of nephrotic syndrome--review. (PubMed id 16752799)9 ObeidovA! H....Tesar V. (Prague Med Rep 2006)
    165. Differential role of transient receptor potential channels in Ca2+ entry and proliferation of prostate cancer epithelial cells. (PubMed id 16489003)9 Thebault S....Prevarskaya N. (Cancer Res. 2006)
    166. TRPC channel expression during calcium-induced differentiation of human gingival keratinocytes. (PubMed id 16051466)9 Cai S....Izutsu K.T. (J. Dermatol. Sci. 2005)
    167. Endogenous TRPC1, TRPC3, and TRPC7 proteins combine to form native store-operated channels in HEK-293 cells. (PubMed id 15972814)9 Zagranichnaya T.K....Villereal M.L. (J. Biol. Chem. 2005)
    168. TRPC3 mediates pyrimidine receptor-induced depolarization of cerebral arteries. (PubMed id 15604128)9 Reading S.A....Brayden J.E. (Am. J. Physiol. Heart Circ. Physiol. 2005)
    169. Expression and association of TRPC subtypes with Orai1 and STIM1 in human parathyroid. (PubMed id 20194530)9 Lu M....Forsberg L. (J. Mol. Endocrinol. 2010)
    170. Stress-induced switch in Numb isoforms enhances Notch-dependent expression of subtype-specific transient receptor potential channel. (PubMed id 20038578)9 Kyriazis G.A....Chan S.L. (J. Biol. Chem. 2010)
    171. Transcriptome analysis of mammary tissues reveals complex patterns of transporter gene expression during pregnancy and lactation. (PubMed id 19947944)9 Anantamongkol U....Krishnamra N. (Cell Biol. Int. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7225 HGNC: 12338 AceView: TRPC6 Ensembl:ENSG00000137672 euGenes: HUgn7225
    ECgene: TRPC6 H-InvDB: TRPC6

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TRPC6 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=TRPC6[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TRPC6 gene:
    Search GeneIP for patents involving TRPC6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of TRPC6
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TRPC6   OriGene RNAi products in human, mouse, rat for TRPC6  
     OriGene qPCR primer pairs and template standards for TRPC6   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TRPC6  
     OriGene qSTAR qPCR primer pairs in human, mouse for TRPC6   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TRPC6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TRPC6   OriGene Custom Protein Services for TRPC6  

     
     
     Block miRNA regulation of human, mouse, rat TRPC6 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TRPC6
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRPC6 Predesigned siRNA for gene silencing in human, mouse, rat TRPC6
     QuantiFast Probe-based Assays in human, mouse, rat TRPC6 QuantiTect SYBR Green Assays in human, mouse, rat TRPC6
     PCR Arrays including human, mouse, rat TRPC6 Search Chromatin IP Primers for TRPC6
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRPC6  GeneGlobe Interaction Network for TRPC6
     Regulatory tfbs in TRPC6 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TRPC6 GenScript cDNA clones with any tag delivered in your preferred vector for TRPC6
     GenScript Custom Assay Services for TRPC6 GenScript Custom overexpressing Cell Line Services for TRPC6
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TRPC6
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TRPC6 antibodies
     TRPC6 proteins
     Antibodies for TRPC6
     See all of Abcam's Antibodies, Kits and Proteins for TRPC6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TRPC6
     Antibodies for TRPC6
     ELISAs for TRPC6
     CLIAs for TRPC6



     Browse ESI BIO Cell Lines and PureStem Progenitors for TRPC6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC6
     SwitchGear 3'UTR luciferase reporter plasmids for TRPC6
     SwitchGear Promoter luciferase reporter plasmids for TRPC6
     ThermoFisher Antibodies for TRPC6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPC6
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRPC6
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRPC6
     LSBio Antibodies in human, mouse, rat for TRPC6
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for TRPC6
      Search eBioscience for proteins for TRPC6
      Search eBioscience for elisas for TRPC6
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TRPC6 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4