TRPC6 Gene

Aliases
for TRPC6 gene

Previous GC identifers: GC11M103516 GC11M102679 GC11M101356 GC11M100860 GC11M100827 GC11M097256

Summaries
for TRPC6 gene

Genomic Views
for TRPC6 gene

RefSeq DNA sequence:

NC_000011.9  NC_018922.1  NT_033899.8  

SwitchGear Promoter luciferase reporter plasmid: TRPC6 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRPC6

TRPC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M101322:  view genomic region     (about GC identifiers)

Proteins
for TRPC6 gene

Explore the universe of human proteins at neXtProt for TRPC6: NX_Q9Y210

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for TRPC6
	GenScript Custom Purified and Recombinant Proteins Services for TRPC6
	Novus Biologicals TRPC6 Proteins
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TRPC6

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of TRPC6
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 3): TRPC6 OriGene Custom Antibody Services for TRPC6
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	Novus Biologicals TRPC6 Antibodies
	Abcam antibodies for TRPC6
	Uscn Antibodies for TRPC6
	ThermoFisher Antibodies for TRPC6

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TRPC6
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TRPC6

Protein Domains /
Families
for TRPC6 gene

ProtoNet protein and cluster: Q9Y210

Function
for TRPC6 gene

miRNA Products:		OriGene 3'-UTR Clone: TRPC6 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRPC6
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate TRPC6 (see all 15):
		hsa-miR-29c hsa-miR-29a hsa-miR-578 hsa-miR-218 hsa-miR-519e* hsa-miR-1297 hsa-miR-33a* hsa-miR-515-5p
		SwitchGear 3'UTR luciferase reporter plasmid: TRPC6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRPC6 (see all 6) OriGene siRNA: TRPC6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRPC6

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for TRPC6

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRPC6 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRPC6 (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TRPC6 (NM_004621)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRPC6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPC6

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TRPC6
		Search LifeMap BioReagents cell lines for TRPC6

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC6

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

(inferred from 2 alleles) (MGI details for Trpc6)

Pathways & Interactions
for TRPC6 gene

	Super-pathway	contained gene-specific pathways
1	Signaling by GPCR	Signaling by GPCR 1.00 Signal Transduction 0.56 GPCR downstream signaling 0.89
2	Platelet activation, signaling and aggregation	Platelet activation, signaling and aggregation 1.00 Hemostasis 0.43
3	Role of second messengers in netrin-1 signaling	Role of second messengers in netrin-1 signaling 1.00 Activation of TRPC channels by Netrin-1 0.60
4	G alpha (q) signalling events	G alpha (q) signalling events 1.00 Gastrin-CREB signalling pathway via PKC and MAPK 0.90
5	Platelet calcium homeostasis	Platelet calcium homeostasis 1.00 Elevation of cytosolic Ca2+ levels 0.47

2 EMD Millipore Pathways for TRPC6

	Sodium channels and transporters- inward current
	Calcium channels

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TRPC6

Intracellular Calcium Signaling

3 BioSystems Pathways for TRPC6

	Endothelins
	EPO signaling pathway
	Nephrin/Neph1 signaling in the kidney podocyte

5/16        Reactome Pathways for TRPC6

	Developmental Biology
	Platelet homeostasis
	Elevation of cytosolic Ca2+ levels
	Signal Transduction
	G alpha (q) signalling events

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

Drugs & Compounds
for TRPC6 gene

Transcripts
for TRPC6 gene

Expression
for TRPC6 gene

TRPC6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAAGTGGTG

2 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	AdiposeVisceral White Adipose			Adipose
	LiverLiver Lobule			Liver
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRPC6 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRPC6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRPC6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRPC6

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC6

Orthologs
for TRPC6 gene

Paralogs
for TRPC6 gene

Paralogs for TRPC6 gene

TRPC4²  TRPC1²  TRPC7²  TRPC5²  TRPC3²  

6 SIMAP similar genes for TRPC6 using alignment to 2 protein entries:     TRPC6_HUMAN (see all proteins):

TRPC3    TRPC7    TRP7    TRPC4    TRPC5    TRPC1

TRPC6 for paralogs           About GeneDecksing


5/11 Pseudogenes.org Pseudogenes for TRPC6 (see all 11)
PGOHUM00000242910 PGOHUM00000239435 PGOHUM00000245787 PGOHUM00000235165 PGOHUM00000235416

Genomic Variants
for TRPC6 gene

10/3083 NCBI SNPs in TRPC6 are shown (see all 3083)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1214343911,2	C,F,	pathogenic	136064605(-)	GGCCAA/GTGAGC	2	N S	mis1		1		NA	4550
rs729842061,2	C,	--	97256303(+)	GCTGAC/TAGTGC	1	--	ds5001		0	--	--	--	--
rs1178953431,2	C,F,	--	97256664(+)	TCATCA/G/TCTTTT	2	--	ut31		1		EA	120
rs1166907271,2	C,	--	97256708(+)	AGTAAC/AAACAA	1	--	ut31		1		WA	118
rs1426553351,2	C,	--	97256715(+)	ACAACA/CACCTC	1	--	ut31		0	--	--	--	--
rs1460337361,2	C,	--	97256783(+)	ACATAC/TTGAAA	1	--	ut31		0	--	--	--	--
rs1385589201,2	C,	--	97256793(+)	AATAAC/GAGATA	1	--	ut31		0	--	--	--	--
rs1129161711,2	C,	--	97257227(+)	TATCAA/GTCATG	1	--	ut31		2		CSA WA	120
rs1493031181,2	C,	--	97257237(+)	GTGCAC/TTGAGG	1	--	ut31		0	--	--	--	--
rs1447141631,2	C,	--	97257420(+)	AGTAAC/TGTGGG	1	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for TRPC6 (101322295 - 101572295 bp, first 250kb of TRPC6)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for TRPC6
     3 CNVs: 85976 48678 101316
     7 Indels: 24601 75783 42501 44804 44805 85977 75784
Human Gene Mutation Database (HGMD): TRPC6

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRPC6

DNA2.0 Custom Variant and Variant Library Synthesis for TRPC6

Disorders / Diseases
for TRPC6 gene

20/32 diseases for TRPC6

6 Novoseek disease relationships for TRPC6 gene    About this table

Publications
for TRPC6 gene

PubMed articles for TRPC6 gene, integrated from 9 sources (see all 173) (see top 10): (articles sorted by number of sources associating them with TRPC6)

Utopia: connect your pdf to the dynamic world of online information

1. Identification and assignment of the human transient receptor potential channel 6 gene TRPC6 to chromosome 11q21-22. (PubMed id 9925922)^{1, 2, 3} D'Esposito M.... Ciccodicola A. (1998)
2. TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. (PubMed id 15924139)^{1, 2, 9} Reiser J.... Pollak M.R. (2005)
3. A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. (PubMed id 15879175)^{1, 2, 9} Winn M.P....Rosenberg P.B. (2005)
4. Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. (PubMed id 9930701)^{1, 2, 9} Hofmann T....Schultz G. (1999)
5. TRPC6 mutations in children with steroid-resistant ne phrotic syndrome and atypical phenotype. (PubMed id 21734084)^{1, 2} Gigante M....Gesualdo L. (2011)
6. RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC. (PubMed id 17850865)^{1, 2} Lussier M.P.... Boulay G. (2008)
7. MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC. (PubMed id 15757897)^{1, 2} Lussier M.P....Boulay G. (2005)
8. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. (PubMed id 16382100)^{1, 3} Clapham D.E....Schultz G. (2005)
9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
10. TRP4 (CCE1) protein is part of native calcium release-activated Ca2+- like channels in adrenal cells. (PubMed id 10816590)^{1, 2} Philipp S....Flockerzi V. (2000)
11. Identification and functional analysis of a novel TRP C6 mutation associated with late onset familial focal segmental glomerulosclero sis in Chinese patients. (PubMed id 19124028)^{1, 9} Zhu B....Wang W.M. (2009)
12. Downregulation of TRPC6 protein expression by high glucose, a possible mechanism for the impaired Ca2+ signaling in glomerular mesangial cells in diabetes. (PubMed id 17699555)^{1, 9} Graham S....Ma R. (2007)
13. The canonical transient receptor potential 6 channel as a putative phosphatidylinositol 3,4,5-trisphosphate-sensitive calcium entry system. (PubMed id 15362854)^{1, 9} Tseng P.H....Chen C.S. (2004)
14. TRPC6 mutational analysis in a large cohort of patien ts with focal segmental glomerulosclerosis. (PubMed id 19458060)^{1, 9} SantA-n S....Torra R. (2009)
15. TRPC6 mutations associated with focal segmental glomerulosclerosis cause constitutive activation of NFAT-dependent transcription. (PubMed id 19129465)^{1, 9} SchlAPndorff J....Pollak M.R. (2009)
16. N-linked protein glycosylation is a major determinant for basal TRPC3 and TRPC6 channel activity. (PubMed id 12970363)^{1, 9} Dietrich A....Gudermann T. (2003)
17. Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation Nove l mechanism of cardiac stress modulation by PDE5 inhibition. (PubMed id 19961855)^{1, 9} Koitabashi N....Kass D.A. (2010)
18. Canonical transient receptor potential channel (TRPC)3 and TRPC6 associate with large-conductance Ca2+-activated K+ (BKCa) channels: role in BKCa trafficking to the surface of cultured podocytes. (PubMed id 19052171)^{1, 9} Kim E.Y....Dryer S.E. (2009)
19. Regulation of TRPC6 channel activity by tyrosine phosphorylation. (PubMed id 14761972)^{1, 9} Hisatsune C....Mikoshiba K. (2004)
20. Capacitative calcium entry and transient receptor potential canonical 6 expression control human hepatoma cell proliferation. (PubMed id 18506892)^{1, 9} El Boustany C....Capiod T. (2008)
21. VEGF-mediated elevated intracellular calcium and angiogenesis in human microvascular endothelial cells in vitro are inhibited by dominant negative TRPC6. (PubMed id 18800249)^{1, 9} Hamdollah Zadeh M.A....Bates D.O. (2008)
22. Heteromultimeric TRPC6-TRPC7 channels contribute to arginine vasopressin-induced cation current of A7r5 vascular smooth muscle cells. (PubMed id 16690880)^{1, 9} Maruyama Y....Cole W.C. (2006)
23. Blockade of TRPC6 channels induced G2/M phase arrest and suppressed growth in human gastric cancer cells. (PubMed id 19610066)^{1, 9} Cai R....Wang Y. (2009)
24. Diacylglycerol activates the influx of extracellular cations in T-lymphocytes independently of intracellular calcium-store depletion and possibly involving endogenous TRP6 gene products. (PubMed id 11988098)^{1, 9} Gamberucci A....Benedetti A. (2002)
25. [Mechanism of cardiac hypertrophy via diacylglycerol- sensitive TRPC channels] (PubMed id 20190513)^{1, 9} Nishida M....Kurose H. (2010)
26. TRPC6 contributes to the Ca(2+) leak of human erythrocytes. (PubMed id 18209485)^{1, 9} Foller M....Huber S.M. (2008)
27. Store-operated Ca2+ channels formed by TRPC1, TRPC6 and Orai1 and non-store-operated channels formed by TRPC3 are involved in the regulation of NADPH oxidase in HL-60 granulocytes. (PubMed id 18436303)^{1, 9} Brechard S....Tschirhart E.J. (2008)
28. Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension. (PubMed id 15358862)^{1, 9} Yu Y....Yuan J.X. (2004)
29. Attenuation of canonical transient receptor potential -like channel 6 expression specifically reduces the diacylglycerol-mediated inc rease in intracellular calcium in human myometrial cells. (PubMed id 19940041)^{1, 9} Chung D....Sanborn B.M. (2010)
30. High glucose enhances transient receptor potential channel canonical type 6-dependent calcium influx in human platelets via phosphatidylinositol 3-kinase-dependent pathway. (PubMed id 18258814)^{1, 9} Liu D....Tepel M. (2008)
31. Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces the change of calcium mobilization via TRPC ion channels in cultured human corporal smooth muscle cells. (PubMed id 16034470)^{1, 9} So I....Lee S.W. (2005)
32. Store-operated Ca2+ entry in first trimester and term human placenta. (PubMed id 12766233)^{1, 9} Clarson L.H....Powell T. (2003)
33. mRNA distribution analysis of human TRPC family in CNS and peripheral tissues. (PubMed id 12531519)^{1, 9} Riccio A....Pangalos M.N. (2002)
34. Molecular identification and localization of Trp homologues, putative calcium channels, in pregnant human uterus. (PubMed id 12356946)^{1, 9} Dalrymple A....Tribe R.M. (2002)
35. Expression of transient receptor potential C6 and related transient receptor potential family members in human airway smooth muscle and lung tissue. (PubMed id 12871853)^{1, 9} Corteling R.L....Hall I.P. (2004)
36. Enhanced capacitative calcium entry and TRPC channel gene expression in human LES smooth muscle. (PubMed id 12736151)^{1, 9} Wang J....Preiksaitis H.G. (2003)
37. TRPC6 gene variants in Czech adult patients with focal segmental glomerulosclerosis and minimal change disease. (PubMed id 22980509)¹ Obeidova L....Tesar V. (2012)
38. Pulsatile atheroprone shear stress affects the express ion of transient receptor potential channels in human endothelial cells. (PubMed id 22566504)¹ Thilo F....Tepel M. (2012)
39. Diacylglycerol-containing oleic acid induces increases in [Ca(2+)](i) via TRPC3/6 channels in human T-cells. (PubMed id 22306362)¹ Carrillo C....Khan N.A. (2012)
40. The upregulation of TRPC6 contributes to Ca^^+ signali ng and actin assembly in human mesangial cells after chronic hypoxia. (PubMed id 22554521)¹ Liao C....Jiao J. (2012)
41. The possible role of TRPC6 in atopic dermatitis. (PubMed id 22000711)¹ Sun X.D....Gao X.H. (2012)
42. Do cysteine residues regulate transient receptor poten tial canonical type 6 channel protein expression? (PubMed id 22004559)¹ Thilo F....Tepel M. (2012)
43. TRPC6 gene variants in Turkish children with steroid-r esistant nephrotic syndrome. (PubMed id 21511817)¹ Mir S....Sozeri B. (2012)
44. Involvement of phosphoinositide 3-kinase and PTEN prot ein in mechanism of activation of TRPC6 protein in vascular smooth muscle cells. (PubMed id 22493444)¹ Monet M....Boulay G. (2012)
45. Cilostazol suppresses angiotensin II-induced vasocons triction via protein kinase A-mediated phosphorylation of the transient recepto r potential canonical 6 channel. (PubMed id 21799177)¹ Nishioka K....Kurose H. (2011)
46. cAMP activates TRPC6 channels via the phosphatidylino sitol 3-kinase (PI3K)-protein kinase B (PKB)-mitogen-activated protein kinase k inase (MEK)-ERK1/2 signaling pathway. (PubMed id 21487005)¹ Shen B....Yao X. (2011)
47. No association between the SNPs (rs56134796; rs3824934 ; rs41302375) in the TRPC6 gene promoter and infantile hypertrophic pyloric sten osis in Chinese people. (PubMed id 21822655)¹ Ju J.J....Yuan Z.W. (2011)
48. The transient receptor potential (TRP) channel TRPC3 TRP domain and AMP-activated protein kinase binding site are required for TRPC3 activation by erythropoietin. (PubMed id 21757714)¹ Hirschler-Laszkiewicz I....Miller B.A. (2011)
49. Abundance of TRPC6 protein in glomerular mesangial ce lls is decreased by ROS and PKC in diabetes. (PubMed id 21525431)¹ Graham S....Ma R. (2011)
50. Balancing calcium signals through TRPC5 and TRPC6 in podocytes. (PubMed id 21980113)¹ Greka A. and Mundel P. (2011)
51. Tyrosine phosphorylation-dependent activation of TRPC 6 regulated by PLC-I^1 and nephrin: effect of mutations associated with focal se gmental glomerulosclerosis. (PubMed id 21471003)¹ Kanda S....Hattori S. (2011)
52. Transient receptor potential canonical channel 6 link s Ca2+ mishandling to cystic fibrosis transmembrane conductance regulator chann el dysfunction in cystic fibrosis. (PubMed id 20203293)¹ Antigny F....Vandebrouck C. (2011)
53. Functional role of the calmodulin- and inositol 1,4,5 -trisphosphate receptor-binding (CIRB) site of TRPC6 in human platelet activati on. (PubMed id 21757000)¹ Dionisio N....Rosado J.A. (2011)
54. The over-expression of TRPC6 channels in HEK-293 cell s favours the intracellular accumulation of zinc. (PubMed id 21864503)¹ Gibon J....Bouron A. (2011)
55. Lack of association between transient receptor potent ial cation channel 6 polymorphisms and primary membranous glomerulonephritis. (PubMed id 20540633)¹ Chen W.C....Chen Y.H. (2010)
56. Genetic Risk Factors for Hepatopulmonary Syndrome in Patients With Advanced Liver Disease. (PubMed id 20346360)¹ Roberts K.E....Fallon M.B. (2010)
57. A Three-Stage Genome-Wide Association Study of Genera l Cognitive Ability: Hunting the Small Effects. (PubMed id 20306291)¹ Davis O.S....Plomin R. (2010)
58. Expression of transient receptor potential c6 channel s in human lung macrophages. (PubMed id 19843708)¹ Finney-Hayward T.K....Donnelly L.E. (2010)
59. A new role for PTEN in regulating transient receptor potential canonical channel 6-mediated Ca2+ entry, endothelial permeability, an d angiogenesis. (PubMed id 20705603)¹ Kini V....Mehta D. (2010)
60. Protein kinase C-dependent phosphorylation of transie nt receptor potential canonical 6 (TRPC6) on serine 448 causes channel inhibiti on. (PubMed id 20961851)¹ Bousquet S.M....Boulay G. (2010)
61. A role for receptor-operated Ca2+ entry in human pulm onary artery smooth muscle cells in response to hypoxia. (PubMed id 20533864)¹ Tang C....Gu Y. (2010)
62. Receptor channel TRPC6 is a key mediator of Notch-dri ven glioblastoma growth and invasiveness. (PubMed id 20028870)¹ Chigurupati S....Chan S.L. (2010)
63. Involvement of Rab9 and Rab11 in the intracellular tr afficking of TRPC6. (PubMed id 20346379)¹ Cayouette S....Boulay G. (2010)
64. The role of TRPC6 in HGF-induced cell proliferation o f human prostate cancer DU145 and PC3 cells. (PubMed id 20835261)¹ Wang Y....Wang P. (2010)
65. Selective interference with TRPC3/6 channels disrupts OX1 receptor signalling via NCX and reveals a distinct calcium influx pathway. (PubMed id 20728215)¹ Louhivuori L.M....Akerman K.E. (2010)
66. Renal TRPathies. (PubMed id 20395377)¹ Dietrich A....Gudermann T. (2010)
67. Essential role of TRPC6 channels in G2/M phase transi tion and development of human glioma. (PubMed id 20554944)¹ Ding X....Wang Y. (2010)
68. TRPC3 activation by erythropoietin is modulated by TRPC6. (PubMed id 19074769)¹ Hirschler-Laszkiewicz I....Miller B.A. (2009)
69. A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension. (PubMed id 19380626)¹ Yu Y....Yuan J.X. (2009)
70. A novel TRPC6 mutation that causes childhood FSGS. (PubMed id 19936226)¹ Heeringa S.F....Hildebrandt F. (2009)
71. Regulation of cardiac hypertrophy by the formation of G protein-coupled receptor--TRPC channel protein complex. (PubMed id 19749484)¹ Nishida M....Kurose H. (2009)
72. Dynamic interaction of hTRPC6 with the Orai1-STIM1 co mplex or hTRPC3 mediates its role in capacitative or non-capacitative Ca(2+) en try pathways. (PubMed id 19260825)¹ Jardin I....Rosado J.A. (2009)
73. Evidence for inflammatory signaling in idiopathic pul monary artery hypertension: TRPC6 and nuclear factor-kappaB. (PubMed id 19414653)¹ Hamid R. and Newman J.H. (2009)
74. Sensitizing the Slit Diaphragm with TRPC6 ion channels. (PubMed id 18784209)¹ MAPller C.C....Reiser J. (2009)
75. Expression of TRPC6 in benign and malignant human pro state tissues. (PubMed id 19701218)¹ Yue D....Ren C.S. (2009)
76. Critical role of TRPC6 channels in VEGF-mediated angi ogenesis. (PubMed id 19394138)¹ Ge R....Wang Y. (2009)
77. Synergistic activation of vascular TRPC6 channel by r eceptor and mechanical stimulation via phospholipase C/diacylglycerol and phosp holipase A2/omega-hydroxylase/20-HETE pathways. (PubMed id 19443836)¹ Inoue R....Ito Y. (2009)
78. Infantile hypertrophic pyloric stenosis: evaluation o f three positional candidate genes, TRPC1, TRPC5 and TRPC6, by association anal ysis and re-sequencing. (PubMed id 19701773)¹ Everett K.V....Chung E.M. (2009)
79. Revisiting TRPC1 and TRPC6 mechanosensitivity. (PubMed id 17957383)¹ Gottlieb P....Honore E. (2008)
80. Elucidation of a TRPC6-TRPC5 channel cascade that restricts endothelial cell movement. (PubMed id 18495872)¹ Chaudhuri P....Graham L.M. (2008)
81. Phosphoproteome of resting human platelets. (PubMed id 18088087)² Zahedi R.P.... Sickmann A. (2008)
82. Specific TRPC6 channel activation, a novel approach to stimulate keratinocyte differentiation. (PubMed id 18818211)¹ MA1ller M....Leuner K. (2008)
83. Phosphatidylinositol 4,5-bisphosphate enhances store-operated calcium entry through hTRPC6 channel in human platelets. (PubMed id 17719101)¹ Jardin I....Rosado J.A. (2008)
84. Nitric oxide-cGMP-protein kinase G pathway negatively regulates vascular transient receptor potential channel TRPC6. (PubMed id 18617565)¹ Takahashi S....Inoue R. (2008)
85. Snapin, a new regulator of receptor signaling, augments alpha1A-adrenoceptor-operated calcium influx through TRPC6. (PubMed id 17684020)¹ Suzuki F....Muramatsu I. (2007)
86. Integration of phosphoinositide- and calmodulin-mediated regulation of TRPC6. (PubMed id 17317623)¹ Kwon Y....Montell C. (2007)
87. TRPC6. (PubMed id 17217054)¹ Dietrich A. and Gudermann T. (2007)
88. Galphaq-TRPC6-mediated Ca2+ entry induces RhoA activation and resultant endothelial cell shape change in response to thrombin. (PubMed id 17197445)¹ Singh I....Mehta D. (2007)
89. Orai proteins interact with TRPC channels and confer responsiveness to store depletion. (PubMed id 17360584)¹ Liao Y....Birnbaumer L. (2007)
90. Transient receptor potential channel 6-mediated, localized cytosolic [Na+] transients drive Na+/Ca2+ exchanger-mediated Ca2+ entry in purinergically stimulated aorta smooth muscle cells. (PubMed id 17872462)¹ Poburko D....van Breemen C. (2007)
91. Expression of transient receptor channel proteins in human fundal myometrium in pregnancy. (PubMed id 16527499)¹ Ku C.Y....Sanborn B.M. (2006)
92. TRPC6 in glomerular health and disease: what we know and what we believe. (PubMed id 17116414)¹ Schlondorff J.S. and Pollak M.R. (2006)
93. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)¹ Olsen J.V....Mann M. (2006)
94. Human TRPC6 expressed in HEK 293 cells forms non-selective cation channels with limited Ca2+ permeability. (PubMed id 16439426)¹ Estacion M....Schilling W.P. (2006)
95. Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx. (PubMed id 15623527)¹ Bandyopadhyay B.C....Ambudkar I.S. (2005)
96. Slit or pore? A mutation of the ion channel TRPC6 causes FSGS. (PubMed id 15998650)¹ Walz G. (2005)
97. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
98. Exocytotic insertion of TRPC6 channel into the plasma membrane upon Gq protein-coupled receptor activation. (PubMed id 14662757)¹ Cayouette S....Boulay G. (2004)
99. Interaction of TRPC2 and TRPC6 in erythropoietin modulation of calcium influx. (PubMed id 14699131)¹ Chu X....Miller B.A. (2004)
100. Activation of human TRPC6 channels by receptor stimulation. (PubMed id 15023993)¹ Estacion M....Schilling W.P. (2004)
101. Cytoskeletal reorganization internalizes multiple transient receptor potential channels and blocks calcium entry into human neutrophils. (PubMed id 14688372)¹ Itagaki K....Hauser C.J. (2004)
102. Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. (PubMed id 14505576)¹ Yuan J.P....Worley P.F. (2003)
103. Role and regulation of TRP channels in neutrophil granulocytes. (PubMed id 12765698)¹ Heiner I....Luckhoff A. (2003)
104. Expression profile of the transient receptor potential (TRP) family in neutrophil granulocytes: evidence for currents through long TRP channel 2 induced by ADP-ribose and NAD. (PubMed id 12564954)¹ Heiner I....Luckhoff A. (2003)
105. Formation of novel TRPC channels by complex subunit interactions in embryonic brain. (PubMed id 12857742)¹ Strubing C....Clapham D.E. (2003)
106. Subunit composition of mammalian transient receptor potential channels in living cells. (PubMed id 12032305)¹ Hofmann T.... Gudermann T. (2002)
107. Selective association of TRPC channel subunits in rat brain synaptosomes. (PubMed id 12377790)¹ Goel M....Schilling W.P. (2002)
108. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
109. Expression and role of TRPC proteins in human platelets: evidence that TRPC6 forms the store-independent calcium entry channel. (PubMed id 12351388)¹ Hassock S.R....Authi K.S. (2002)
110. Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels. (PubMed id 11290752)¹ Tang J....Zhu M.X. (2001)
111. Cloning, expression and subcellular localization of two novel splice variants of mouse transient receptor potential channel 2. (PubMed id 10998353)¹ Hofmann T....Gudermann T. (2000)
112. Modulation of Ca(2+) entry by polypeptides of the inositol 1,4, 5- trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca(2+) entry. (PubMed id 10611319)¹ Boulay G.... Birnbaumer L. (1999)
113. Linkage of a gene causing familial focal segmental glomerulosclerosis to chromosome 11 and further evidence of genetic heterogeneity. (PubMed id 10368108)¹ Winn M.P....Vance J.M. (1999)
114. Effects of siRNA knock-down of TRPC6 and InsP(3)R1 in vasopressin-induced Ca(2+) oscillations of A7r5 vascular smooth muscle cells. (PubMed id 18835357)⁹ Li M....Wier W.G. (2008)
115. Role of endogenous TRPC6 channels in Ca2+ signal generation in A7r5 smooth muscle cells. (PubMed id 16204251)⁹ Soboloff J....Gill D.L. (2005)
116. Abnormal expression, localization and interaction of canonical transient receptor potential ion channels in human breast cancer cell lines and tissues: a potential target for breast cancer diagnosis and therapy. (PubMed id 19689790)⁹ Aydar E....Palmer C. (2009)
117. Induction of TRPC6 channel in acquired forms of proteinuric kidney disease. (PubMed id 17167110)⁹ Moller C.C....Reiser J. (2007)
118. Role of transient receptor potential canonical 6 (TRPC6) in non-transferrin-bound iron uptake in neuronal phenotype PC12 cells. (PubMed id 14640978)⁹ Mwanjewe J. and Grover A.K. (2004)
119. PDGF stimulates pulmonary vascular smooth muscle cell proliferation by upregulating TRPC6 expression. (PubMed id 12529250)⁹ Yu Y....Yuan J.X. (2003)
120. TRPC6 and FSGS: the latest TRP channelopathy. (PubMed id 17459670)⁹ Mukerji N....Winn M.P. (2007)
121. The overexpression of presenilin2 and Alzheimer's-disease-linked presenilin2 variants influences TRPC6-enhanced Ca2+ entry into HEK293 cells. (PubMed id 15601622)⁹ Lessard C.B....Boulay G. (2005)
122. TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling. (PubMed id 17099778)⁹ Kuwahara K....Olson E.N. (2006)
123. Flufenamic acid is a tool for investigating TRPC6-mediated calcium signalling in human conditionally immortalised podocytes and HEK293 cells. (PubMed id 19232718)⁹ Foster R.R....Saleem M.A. (2009)
124. Expression of TRPC6 channels in human epithelial breast cancer cells. (PubMed id 18452628)⁹ Guilbert A....Ouadid-Ahidouch H. (2008)
125. Ca(2+)-calmodulin regulates receptor-operated Ca(2+) entry activity of TRPC6 in HEK-293 cells. (PubMed id 12379180)⁹ Boulay G. (2002)
126. Isoform-selective physical coupling of TRPC3 channels to IP3 receptors in smooth muscle cells regulates arterial contractility. (PubMed id 20378853)⁹ Adebiyi A....Jaggar J.H. (2010)
127. High glucose-induced oxidative stress increases trans ient receptor potential channel expression in human monocytes. (PubMed id 20068131)⁹ Wuensch T....Tepel M. (2010)
128. Identification of two domains involved in the assembly of transient receptor potential canonical channels. (PubMed id 16916799)⁹ Lepage P.K....Boulay G. (2006)
129. Transient receptor potential protein subunit assembly and membrane distribution in human platelets. (PubMed id 16270640)⁹ Brownlow S.L. and Sage S.O. (2005)
130. Bosentan inhibits transient receptor potential channel expression in pulmonary vascular myocytes. (PubMed id 15317671)⁹ Kunichika N....Yuan J.X. (2004)
131. Activation, subunit composition and physiological relevance of DAG-sensitive TRPC proteins. (PubMed id 15104178)⁹ Gudermann T....Dietrich A. (2004)
132. Evidence of a role for TRPC channels in VEGF-mediated increased vascular permeability in vivo. (PubMed id 14551041)⁹ Pocock T.M....Bates D.O. (2004)
133. A diacylglycerol-activated Ca2+ channel in PC12 cells (an adrenal chromaffin cell line) correlates with expression of the TRP-6 (transient receptor potential) protein. (PubMed id 11535132)⁹ Tesfai Y....Barritt G.J. (2001)
134. Increased store-operated and 1-oleoyl-2-acetyl-sn-glycerol-induced calcium influx in monocytes is mediated by transient receptor potential canonical channels in human essential hypertension. (PubMed id 17351372)⁹ Liu D.Y....Tepel M. (2007)
135. Plasticity of TRPC expression in arterial smooth muscle: correlation with store-operated Ca2+ entry. (PubMed id 15561760)⁹ Bergdahl A....Hellstrand P. (2005)
136. TRPC6 - a new podocyte gene involved in focal segmental glomerulosclerosis. (PubMed id 16290061)⁹ Kriz W. (2005)
137. Signalling mechanisms for TRPC3 channels. (PubMed id 15104179)⁹ Putney J.W....Bird G.S. (2004)
138. Critical role of TRPC6 channels in G2 phase transitio n and the development of human oesophageal cancer. (PubMed id 19651628)⁹ Shi Y....Wang Y.Z. (2009)
139. TRPC channels function independently of STIM1 and Orai1. (PubMed id 19332491)⁹ DeHaven W.I....Putney J.W. (2009)
140. Increased TRPC3 expression in vascular endothelium of patients with malignant hypertension. (PubMed id 19136933)⁹ Thilo F....Tepel M. (2009)
141. R168H and V165X mutant podocin might induce different degrees of podocyte injury via different molecular mechanisms. (PubMed id 19674119)⁹ Fan Q....Guan N. (2009)
142. (Endo)cannabinoids mediate different Ca2+ entry mechanisms in human bronchial epithelial cells. (PubMed id 19255745)⁹ Gkoumassi E....Zaagsma J. (2009)
143. 2007 Young Investigator Award: TRP'ing into a new era for glomerular disease. (PubMed id 18434567)⁹ Winn M.P. (2008)
144. Differences in STIM1 and TRPC expression in proximal and distal pulmonary arterial smooth muscle are associated with differences in Ca2+ responses to hypoxia. (PubMed id 18424621)⁹ Lu W....Sylvester J.T. (2008)
145. Bigenic heterozygosity and the development of steroid-resistant focal segmental glomerulosclerosis. (PubMed id 18443213)⁹ Lowik M....van den Heuvel L. (2008)
146. Expression profiling and electrophysiological studies suggest a major role for Orai1 in the store-operated Ca2+ influx pathway of platelets and megakaryocytes. (PubMed id 18569867)⁹ Tolhurst G....Mahaut-Smith M.P. (2008)
147. Genetic basis of nephrotic syndrome--review. (PubMed id 16752799)⁹ Obeidova H....Tesar V. (2006)
148. Differential role of transient receptor potential channels in Ca2+ entry and proliferation of prostate cancer epithelial cells. (PubMed id 16489003)⁹ Thebault S....Prevarskaya N. (2006)
149. TRPC channel expression during calcium-induced differentiation of human gingival keratinocytes. (PubMed id 16051466)⁹ Cai S....Izutsu K.T. (2005)
150. Endogenous TRPC1, TRPC3, and TRPC7 proteins combine to form native store-operated channels in HEK-293 cells. (PubMed id 15972814)⁹ Zagranichnaya T.K....Villereal M.L. (2005)
151. TRPC3 mediates pyrimidine receptor-induced depolariza tion of cerebral arteries. (PubMed id 15604128)⁹ Reading S.A....Brayden J.E. (2005)
152. Expression and association of TRPC subtypes with Orai 1 and STIM1 in human parathyroid. (PubMed id 20194530)⁹ Lu M....Forsberg L. (2010)
153. Stress-induced switch in Numb isoforms enhances Notch -dependent expression of subtype-specific transient receptor potential channel. (PubMed id 20038578)⁹ Kyriazis G.A....Chan S.L. (2010)
154. Transcriptome analysis of mammary tissues reveals com plex patterns of transporter gene expression during pregnancy and lactation. (PubMed id 19947944)⁹ Anantamongkol U....Krishnamra N. (2010)
155. Nitric oxide lacks direct effect on TRPC5 channels bu t suppresses endogenous TRPC5-containing channels in endothelial cells. (PubMed id 20390293)⁹ Wong C.O....Yao X. (2010)
156. Reduction in TRPC4 expression specifically attenuates G-protein coupled receptor-stimulated increases in intracellular calcium in hu man myometrial cells. (PubMed id 19523685)⁹ Ulloa A....Sanborn B.M. (2009)
157. Expression of ion channels of the TRP family in articular chondrocytes from osteoarthritic patients: changes between native and in vitro propagated chondrocytes. (PubMed id 18836817)⁹ Gavenis K....Schmidt-Rohlfing B. (2009)
158. TRPC Channels Mediate a Muscarinic Receptor-Induced A fterdepolarization in Cerebral Cortex. (PubMed id 19675237)⁹ Yan H.D....Andrade R. (2009)
159. Diabetes modulates capacitative calcium entry and exp ression of transient receptor potential canonical channels in human saphenous v ein. (PubMed id 19393642)⁹ Chung A.W....van Breemen C. (2009)
160. Transient receptor potential (TRP) channels, vascular tone and autoregulation of cerebral blood flow. (PubMed id 18215190)⁹ Brayden J.E....Reading S. (2008)
161. TRPC channels as STIM1-regulated store-operated channels. (PubMed id 17517433)⁹ Worley P.F....Muallem S. (2007)
162. Renin-angiotensin axis blockade reduces proteinuria in presymptomatic patients with familial FSGS. (PubMed id 17530296)⁹ Copelovitch L....Kaplan B.S. (2007)
163. Pathogenesis of nonimmune glomerulopathies. (PubMed id 18039119)⁹ Kwoh C....Shaw A. (2006)
164. Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin. (PubMed id 16628251)⁹ Huber T.B....Shaw A.S. (2006)
165. Role of transient receptor potential C3 in TNF-alpha-enhanced calcium influx in human airway myocytes. (PubMed id 16574942)⁹ White T.A....Wylam M.E. (2006)
166. Arteriolar myogenic signalling mechanisms: Implications for local vascular function. (PubMed id 16543619)⁹ Hill M.A....Murphy T.V. (2006)
167. Phosphatidyl-inositide signalling proteins in a novel class of sensory cells in the mammalian olfactory epithelium. (PubMed id 15926917)⁹ Elsaesser R....Paysan J. (2005)
168. Recent developments in vascular endothelial cell transient receptor potential channels. (PubMed id 16254217)⁹ Yao X. and Garland C.J. (2005)
169. Phospholipase cgamma1 is required for activation of store-operated channels in human keratinocytes. (PubMed id 15654973)⁹ Tu C.L....Bikle D.D. (2005)
170. Mechanism of inhibition of TRPC cation channels by 2-aminoethoxydiphenylborane. (PubMed id 15933213)⁹ Lievremont J.P....Putney J.W. (2005)
171. Expression of capacitative calcium TrpC proteins in rat myometrium during pregnancy. (PubMed id 14627551)⁹ Babich L.G....Sanborn B.M. (2004)

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