Aliases for TRPC6 Gene
External Ids for TRPC6 Gene
Previous Symbols for TRPC6 Gene
The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009]
GeneCards Summary for TRPC6 Gene
TRPC6 (Transient Receptor Potential Cation Channel, Subfamily C, Member 6) is a Protein Coding gene. Diseases associated with TRPC6 include diencephalic neoplasm and familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis. Among its related pathways are Signaling by GPCR and L1CAM interactions. GO annotations related to this gene include store-operated calcium channel activity and inositol 1,4,5 trisphosphate binding. An important paralog of this gene is TRPC5.
UniProtKB/Swiss-Prot for TRPC6 Gene
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion