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TRPC5 Gene

protein-coding   GIFtS: 63
GCID: GC0XM111017

Transient Receptor Potential Cation Channel, Subfamily C,...

  See TRPC5-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transient Receptor Potential Cation Channel, Subfamily C, Member 51 2     Short Transient Receptor Potential Channel 52
TRP52 3 5     Transient Receptor Potential Channel 52
Transient Receptor Protein 52 3     TrpC53
TRP-52 3     hTRP-53
hTRP52 3     

External Ids:    HGNC: 123371   Entrez Gene: 72242   Ensembl: ENSG000000723157   OMIM: 3003345   UniProtKB: Q9UL623   

Export aliases for TRPC5 gene to outside databases

Previous GC identifers: GC0XM106320 GC0XM108164 GC0XM109042 GC0XM109781 GC0XM110823 GC0XM110904 GC0XM100639


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRPC5 Gene:
This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor
potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a
receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a
heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including
calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein
(MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1).
(provided by RefSeq, May 2010)

GeneCards Summary for TRPC5 Gene:
TRPC5 (transient receptor potential cation channel, subfamily C, member 5) is a protein-coding gene. Diseases associated with TRPC5 include pseudohypoaldosteronism type ii. GO annotations related to this gene include calcium channel activity and inositol 1,4,5 trisphosphate binding. An important paralog of this gene is TRPC4.

UniProtKB/Swiss-Prot: TRPC5_HUMAN, Q9UL62
Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated
by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled
receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular
calcium store depletion

Gene Wiki entry for TRPC5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011651.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRPC5 gene promoter:
         Sp1   RREB-1   NF-YA   HNF-3beta   NF-YB   CBF-A   CBF-B   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRPC5 promoter sequence
   Search Chromatin IP Primers for TRPC5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRPC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq23   Ensembl cytogenetic band:  Xq23   HGNC cytogenetic band: Xq23

TRPC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRPC5 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM111017:  view genomic region     (about GC identifiers)

Start:
111,017,542 bp from pter      End:
111,326,004 bp from pter
Size:
308,463 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRPC5_HUMAN, Q9UL62 (See protein sequence)
Recommended Name: Short transient receptor potential channel 5  
Size: 973 amino acids; 111412 Da
Subunit: Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC1 and/or TRPC4.
Interacts with NHERF (By similarity). Interacts with MX1 and RNF24. Interacts (via C-terminus) with CABP1.
Interacts with SESTD1 (via the spectrin 1 repeat)
Secondary accessions: B2RP53 O75233 Q5JXY8 Q9Y514

Explore the universe of human proteins at neXtProt for TRPC5: NX_Q9UL62

Explore proteomics data for TRPC5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn461
  • Modification sites at PhosphoSitePlus

  • See TRPC5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036603.1  
    ENSEMBL proteins: 
     ENSP00000262839  
    Reactome Protein details: Q9UL62

    TRPC5 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TRP: Voltage-gated ion channels / Transient receptor potential cation channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: TRPC5
    Transient Receptor Potential channels

    Selected InterPro protein domains (see all 7):
     IPR002153 TRPC_channel
     IPR005821 Ion_trans_dom
     IPR004729 TRP_channel
     IPR002110 Ankyrin_rpt
     IPR005461 TRPC5_channel

    Graphical View of Domain Structure for InterPro Entry Q9UL62

    ProtoNet protein and cluster: Q9UL62

    3 Blocks protein domains:
    IPB002153 Transient receptor potential family signature
    IPB005461 Transient receptor potential channel 5 signature
    IPB013555 Transient receptor ion channel II


    UniProtKB/Swiss-Prot: TRPC5_HUMAN, Q9UL62
    Similarity: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC5 sub-subfamily
    Similarity: Contains 4 ANK repeats


    Find genes that share domains with TRPC5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRPC5_HUMAN, Q9UL62
    Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated
    by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled
    receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular
    calcium store depletion
    Enzyme regulation: Calcium channel activity is enhanced by MYLK, that promotes its subcellular localization at the
    plasma membrane

         Genatlas biochemistry entry for TRPC5:
    transient receptor potential non voltage-channel 5,Drosophila store-operated calcium channel (Soc)
    homolog,ubiquitous but predominantly expressed in fetal brain,adult heart,brain,testis,ovaries,activated by
    calcium store depletion component of the capacitative calcium entry channels (homo or heterotetramer),involved in
    mental retardation

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005262calcium channel activity IDA--
    GO:0005515protein binding IPI--
    GO:0015279store-operated calcium channel activity TAS10493832
    GO:0070679inositol 1,4,5 trisphosphate binding IEA--
         
    Find genes that share ontologies with TRPC5           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Trpc5):
     behavior/neurological  cellular  homeostasis/metabolism  nervous system  no phenotypic analysis 

    Find genes that share phenotypes with TRPC5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TRPC5: Trpc5tm1.1Clph Trpc5tm1.1Lbi

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRPC5
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRPC5

    miRNA
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    hsa-mir-29b-2-5p (MIRT038711)

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    Selected qRT-PCR Assays for microRNAs that regulate TRPC5 (see all 28):
    hsa-miR-607 hsa-miR-1288 hsa-miR-4251 hsa-miR-216b hsa-miR-3921 hsa-miR-548a-3p hsa-miR-183* hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidTRPC5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TRPC5

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRPC5_HUMAN, Q9UL62: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol2
    endoplasmic reticulum2
    extracellular1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS10493832
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----
    GO:0034704calcium channel complex IDA--

    Find genes that share ontologies with TRPC5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TRPC5 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    2Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58
    3Netrin-1 signaling
    Netrin-1 signaling
    Role of second messengers in netrin-1 signaling0.00
    4GPCR Pathway
    Breast Cancer Regulation by Stathmin10.58
    5CREB Pathway
    Intracellular Calcium Signaling0.50


    Find genes that share SuperPaths with TRPC5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TRPC5
        Breast Cancer Regulation by Stathmin1
    Intracellular Calcium Signaling

    2 Reactome Pathways for TRPC5
        TRP channels
    Role of second messengers in netrin-1 signaling


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRPC5
    Interactions:

        GeneGlobe Interaction Network for TRPC5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRPC5 (Q9UL623 ENSP000002628394) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC9A3R1O147453, ENSP000002626134I2D: score=2 STRING: ENSP00000262613
    HOMER1Q86YM73, ENSP000003343824I2D: score=1 STRING: ENSP00000334382
    STMN1P169493, ENSP000004104524I2D: score=1 STRING: ENSP00000410452
    STMN3Q9NZ723, ENSP000003590704I2D: score=1 STRING: ENSP00000359070
    TERF1P542743, ENSP000002766034I2D: score=1 STRING: ENSP00000276603
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    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0006816calcium ion transport TAS10493832
    GO:0007399nervous system development TAS10493832
    GO:0007411axon guidance TAS--
    GO:0034220ion transmembrane transport TAS--

    Find genes that share ontologies with TRPC5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRPC5

    1 HMDB Compound for TRPC5    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected IUPHAR Ligands for TRPC5 (TRPC5) (see all 17)    About this table
    LigandTypeActionAffinityPubmed IDs
    Ca2+
    ActivatorNone6.2--
    KB-R7943
    Pore BlockerInhibition5.5817658472
    progesterone
    Pore BlockerInhibition5.321108630
    ML204
    Channel blockerNone521795696
    2-APB
    Pore BlockerAntagonist4.715806115
    rosiglitazone
    ActivatorActivation4.5121406603
    SKF96365
    Channel blockerNone4.51--
    genistein
    ActivatorNone4.5120233211
    7,4'-dihydroxyisoflavone
    ActivatorNone4.51--
    GsMTx-4
    Channel blockerNone4.51--

    7 Novoseek inferred chemical compound relationships for TRPC5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2-aminoethoxydiphenylborane 90.9 1 17351372 (1)
    1-oleoyl-2-acetyl-sn-glycerol 79.2 6 17351372 (3), 12721302 (2)
    calcium 54.9 8 17351372 (3), 15987684 (2), 19398778 (1), 15763245 (1) (see all 5)
    thapsigargin 53.9 1 12736151 (1)
    inositol 1,4,5 trisphosphate 44.4 1 20164195 (1)
    phosphoinositide 24.2 1 15987684 (1)
    lipid 16 3 16270640 (1), 16368680 (1)



    Find genes that share compounds with TRPC5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRPC5 gene: 
    NM_012471.2  

    Unigene Cluster for TRPC5:

    Transient receptor potential cation channel, subfamily C, member 5
    Hs.657709  [show with all ESTs]
    Unigene Representative Sequence: NM_012471
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000262839(uc004epl.1 uc004epm.1)
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    hsa-miR-607 hsa-miR-1288 hsa-miR-4251 hsa-miR-216b hsa-miR-3921 hsa-miR-548a-3p hsa-miR-183* hsa-miR-3658
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    Additional mRNA sequence: 

    AB209258.1 AF054568.1 BC137271.1 BC137274.1 

    2 DOTS entries:

    DT.92068222  DT.121284437 

    7 AceView cDNA sequences:

    BF438823 AF054568 BX090656 NM_012471 AI075962 BE169013 R73905 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRPC5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATTATAAA
    TRPC5 Expression
    About this image

    TRPC5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRPC5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.657709

    UniProtKB/Swiss-Prot: TRPC5_HUMAN, Q9UL62
    Tissue specificity: Expressed in brain with higher levels in fetal brain. Found in cerebellum and occipital pole

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TRPC5 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trpc51 , 5 transient receptor potential cation channel, subfamily more1, 5 90.41(n)1
    96.92(a)1
      X (65.49 cM)5
    220671  NM_009428.21  NP_033454.11 
     1443816715 
    chicken
    (Gallus gallus)
    Aves TRPC51 transient receptor potential cation channel, subfamily more 79(n)
    86.13(a)
      422337  XM_420310.4  XP_420310.2 
    lizard
    (Anolis carolinensis)
    Reptilia TRPC56
    transient receptor potential cation channel, subfa...
    84(a)
    1 ↔ 1
    GL343376.1(529029-653555)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia trpc51 transient receptor potential cation channel, subfamily more 75.72(n)
    84.35(a)
      100493720  XM_002938783.2  XP_002938829.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5558971 short transient receptor potential channel 4-like 69.78(n)
    74.55(a)
      555897  XM_678557.3  XP_683649.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta trpgamma3 calcium ion transport calcium channel 49(a)
    (best of 3)
      36A9   --
    worm
    (Caenorhabditis elegans)
    Secernentea trp-13 Transient-receptor-potential (trp)
    protein
    39(a)   III(8607645-8614376)   --


    ENSEMBL Gene Tree for TRPC5 (if available)
    TreeFam Gene Tree for TRPC5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRPC5 gene
    TRPC42  TRPC12  TRPC72  TRPC62  TRPC32  
    6 SIMAP similar genes for TRPC5 using alignment to 1 protein entry:     TRPC5_HUMAN:
    TRPC4    TRPC1    TRP7    TRPC6    TRPC3    TRPC7

    Find genes that share paralogs with TRPC5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRPC5 (see all 4514)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1378710411,2
    Cuntested1111199044(+) TTAGCA/C/TGGGCG 1 -- int10--------
    rs1846443271,2
    --110997139(+) TACTTA/GATCAA 1 -- ds50010--------
    rs30277571,2
    C,F,H--110997268(-) ATTTAG/AGATGG 1 -- ds50018Minor allele frequency- A:0.04NS EA NA 902
    rs1894770131,2
    C--110997278(+) TGAGGC/TTTCAC 1 -- ds50010--------
    rs30277561,2
    C,F,O,H--110997413(-) GTTCTA/GAAGAG 1 -- ds50016Minor allele frequency- G:0.00NS EA NA 520
    rs1454815121,2
    --110997507(+) ACTTAC/TAAGTT 1 -- ds50010--------
    rs1510567961,2
    C--110997655(+) AATTTG/TAAAAG 1 -- ut310--------
    rs1844381371,2
    --110997935(+) AGGCTA/GGAGAC 1 -- ut310--------
    rs1905777381,2
    --110997995(+) GTTTGA/GAGGCA 1 -- ut310--------
    rs1818126341,2
    --110998617(+) TTTCTA/GATAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TRPC5 (111017542 - 111267542 bp, first 250kb of TRPC5)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TRPC5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675427CNV Deletion23128226
    esv268206CNV Insertion20981092
    nsv7039CNV Loss18451855
    nsv7040CNV Loss18451855
    nsv520386CNV Gain19592680
    nsv526892CNV Gain19592680

    Human Gene Mutation Database (HGMD): TRPC5
    Locus Specific Mutation Databases (LSDB): TRPC5

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRPC5
    DNA2.0 Custom Variant and Variant Library Synthesis for TRPC5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300334    OMIM disorders: --

    1 disease for TRPC5:    
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    pseudohypoaldosteronism type ii


    Find genes that share disorders with TRPC5           About GenesLikeMe

    2 Novoseek inferred disease relationships for TRPC5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    essential hypertension 18.1 3 17351372 (3)
    mental retardation 16.2 3 10493832 (3)

    Genetic Association Database (GAD): TRPC5
    Human Genome Epidemiology (HuGE) Navigator: TRPC5 (1 document)

    Export disorders for TRPC5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRPC5 gene, integrated from 10 sources (see all 86):
    (articles sorted by number of sources associating them with TRPC5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of TRPC5 (HTRP5), the human homologue of a mouse brain receptor-activated capacitative Ca(2+) entry channel. (PubMed id 10493832)1, 2, 3, 9 Sossey-Alaoui K.... Srivastava A.K. (Genomics 1999)
    2. The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5. (PubMed id 20164195)1, 2, 9 Miehe S....Strubing C. (J. Biol. Chem. 2010)
    3. Genome-wide and candidate gene association study of cigarette smoking behaviors. (PubMed id 19247474)1, 4 Caporaso N....Bergen A.W. (PLoS ONE 2009)
    4. Infantile hypertrophic pyloric stenosis: evaluation of three positional candidate genes, TRPC1, TRPC5 and TRPC6, by association analysis and re-sequencing. (PubMed id 19701773)1, 4 Everett K.V....Chung E.M. (Hum. Genet. 2009)
    5. Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells. (PubMed id 16284075)1, 2 Shimizu S.... Mori Y. (J. Physiol. (Lond.) 2006)
    6. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    7. MxA, a member of the dynamin superfamily, interacts with the ankyrin- like repeat domain of TRPC. (PubMed id 15757897)1, 2 Lussier M.P.... Boulay G. (J. Biol. Chem. 2005)
    8. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. (PubMed id 16382100)1, 3 Clapham D.E....Schultz G. (Pharmacol. Rev. 2005)
    9. Subunit composition of mammalian transient receptor potential channels in living cells. (PubMed id 12032305)1, 2 Hofmann T.... Gudermann T. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Molecular determinant of sensing extracellular pH in classical transient receptor potential channel 5. (PubMed id 17981154)1, 9 Kim M.J....So I. (Biochem. Biophys. Res. Commun. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7224 HGNC: 12337 AceView: TRPC5 Ensembl:ENSG00000072315 euGenes: HUgn7224
    ECgene: TRPC5 H-InvDB: TRPC5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRPC5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRPC5 gene:
    Search GeneIP for patents involving TRPC5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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