Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRPC5 Gene

protein-coding   GIFtS: 60
GCID: GC0XM111017

transient receptor potential cation channel, subfamily C,...
 Explore 11 diseases affiliated with
TRPC5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TRPC5    

Aliases
for TRPC5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Transient Receptor Potential Cation Channel, Subfamily C, Member 51 2     Short Transient Receptor Potential Channel 52
TRP52 3 5     Transient Receptor Potential Channel 52
Transient Receptor Protein 52 3     TrpC53
TRP-52 3     HTRP-51
HTRP51     

External Ids:    HGNC: 123371   Entrez Gene: 72242   Ensembl: ENSG000000723157   OMIM: 3003345   UniProtKB: Q9UL623   

Export aliases for TRPC5 gene to outside databases

Previous GC identifers: GC0XM106320 GC0XM108164 GC0XM109042 GC0XM109781 GC0XM110823 GC0XM110904 GC0XM100639


Summaries
for TRPC5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TRPC5:
This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor
potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a
receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric
assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin,
Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24
(RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). (provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: TRPC5_HUMAN, Q9UL62
Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a
phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors.
Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store
depletion

Gene Wiki entry for TRPC5


Genomic Views
for TRPC5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011651.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRPC5 gene promoter:
         Sp1   RREB-1   NF-YA   HNF-3beta   NF-YB   CBF-A   CBF-B   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRPC5 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRPC5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRPC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq23   Ensembl cytogenetic band:  Xq23   HGNC cytogenetic band: Xq23

TRPC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRPC5 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM111017:  view genomic region     (about GC identifiers)

Start:
 111,017,542 bp from pter      End:
 111,326,004 bp from pter
Size:
 308,463 bases      Orientation:
 minus strand

Proteins
for TRPC5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TRPC5_HUMAN, Q9UL62 (See protein sequence)
Recommended Name: Short transient receptor potential channel 5  
Size: 973 amino acids; 111412 Da
Subunit: Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC1 and/or TRPC4. Interacts
with NHERF (By similarity). Interacts with MX1 and RNF24. Interacts (via C-terminus) with CABP1. Interacts with SESTD1
(via the spectrin 1 repeat)
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B2RP53 O75233 Q5JXY8 Q9Y514

Explore the universe of human proteins at neXtProt for TRPC5: NX_Q9UL62

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UL62

    • TRPC5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_036603.1  
    ENSEMBL proteins: 
     ENSP00000262839  
    Reactome Protein details: Q9UL62
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: TRPC5
    OriGene Custom Protein Services for TRPC5 
    GenScript Custom Purified and Recombinant Proteins Services for TRPC5
    Novus Biologicals TRPC5 Protein
    Novus Biologicals TRPC5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TRPC5

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS10493832
    GO:0034704calcium channel complex IDA--


    TRPC5 for ontologies           About GeneDecksing



    TRPC5 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TRPC5
    Browse R&D Systems for Antibodies
    OriGene Antibodies: TRPC5
    OriGene Custom Antibody Services for TRPC5 
    GenScript Custom Superior Antibodies Services for TRPC5
    Novus Biologicals TRPC5 Antibodies
    Search for Antibodies for TRPC5 at Abcam  
    Uscn Antibodies for TRPC5
    ThermoFisher Antibodies for TRPC5

    Assay Products for TRPC5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRPC5
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TRPC5

    Protein Domains /
    Families
    for TRPC5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TRPC5 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR002153 TRPC_channel
     IPR020683 Ankyrin_rpt-contain_dom
     IPR005821 Ion_trans_dom
     IPR004729 TRP_channel
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry Q9UL62

    ProtoNet protein and cluster: Q9UL62

    3 Blocks protein families:
    IPB002153 Transient receptor potential family signature
    IPB005461 Transient receptor potential channel 5 signature
    IPB013555 Transient receptor ion channel II


    UniProtKB/Swiss-Prot: TRPC5_HUMAN, Q9UL62
    Similarity: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC5 sub-subfamily
    Similarity: Contains 4 ANK repeats


    Function
    for TRPC5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TRPC5_HUMAN, Q9UL62
    Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a
    phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors.
    Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store
    depletion
    Enzyme regulation: Calcium channel activity is enhanced by MYLK, that promotes its subcellular localization at the
    plasma membrane

         Genatlas biochemistry entry for TRPC5:
    transient receptor potential non voltage-channel 5,Drosophila store-operated calcium channel (Soc) homolog,ubiquitous
    but predominantly expressed in fetal brain,adult heart,brain,testis,ovaries,activated by calcium store depletion
    component of the capacitative calcium entry channels (homo or heterotetramer),involved in mental retardation

    miRNA
    Products:            		 OriGene 3'-UTR Clone: TRPC5
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRPC5
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate TRPC5 (see all 28):
    hsa-miR-607 hsa-miR-1288 hsa-miR-4251 hsa-miR-216b hsa-miR-3921 hsa-miR-548a-3p hsa-miR-183* hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmid: TRPC5 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRPC5 (see all 7)
    OriGene shRNA RFP: TRPC5
    OriGene siRNA: TRPC5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRPC5

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TRPC5

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRPC5 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRPC5
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TRPC5 (NM_012471)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRPC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPC5 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for TRPC5
    Search LifeMap BioReagents cell lines for TRPC5

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC5

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005262calcium channel activity IDA--
    GO:0005515protein binding IPI--
    GO:0015279store-operated calcium channel activity TAS10493832
    GO:0070679inositol 1,4,5 trisphosphate binding IEA--


    TRPC5 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Trpc5tm1.1Clph for TRPC5
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Trpc5):
     behavior/neurological  nervous system 

    TRPC5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TRPC5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Role of second messengers in netrin-1 signaling
    		Role of second messengers in netrin-1 signaling1.00
    		Activation of TRPC channels by Netrin-10.60
    2Axon guidance
    		Axon guidance1.00
    		Developmental Biology0.69
    3Calcium channels
    		Calcium channels1.00
    4Sodium channels and transporters: inward current
    		Sodium channels and transporters: inward current1.00
    5Netrin-1 signaling
    		Netrin-1 signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for TRPC5
        Sodium channels and transporters- inward current
    Calcium channels

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TRPC5
        Breast Cancer Regulation by Stathmin1
    Intracellular Calcium Signaling

    5        Reactome Pathways for TRPC5
        Developmental Biology
    Netrin-1 signaling
    Role of second messengers in netrin-1 signaling
    Activation of TRPC channels by Netrin-1
    Axon guidance



    TRPC5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRPC5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/53 Interacting proteins for TRPC5 (Q9UL623 ENSP000002628394) via UniProtKB, MINT, STRING, and/or I2D (see all 53)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC9A3R1O147453, ENSP000002626134I2D: score=2 STRING: ENSP00000262613
    HOMER1Q86YM73, ENSP000003343824I2D: score=1 STRING: ENSP00000334382
    STMN1P169493, ENSP000004104524I2D: score=1 STRING: ENSP00000410452
    STMN3Q9NZ723, ENSP000003590704I2D: score=1 STRING: ENSP00000359070
    TERF1P542743, ENSP000002766034I2D: score=1 STRING: ENSP00000276603
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006816calcium ion transport TAS10493832
    GO:0007399nervous system development TAS10493832
    GO:0007411axon guidance TAS--
    GO:0070588calcium ion transmembrane transport ----


    TRPC5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TRPC5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRPC5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRPC5

    1 HMDB Compound for TRPC5    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    7 Novoseek chemical compound relationships for TRPC5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2-aminoethoxydiphenylborane 90.9 1 17351372 (1)
    1-oleoyl-2-acetyl-sn-glycerol 79.2 6 17351372 (3), 12721302 (2)
    calcium 54.9 8 17351372 (3), 15987684 (2), 19398778 (1), 15763245 (1) (see all 5)
    thapsigargin 53.9 1 12736151 (1)
    inositol 1,4,5 trisphosphate 44.4 1 20164195 (1)
    phosphoinositide 24.2 1 15987684 (1)
    lipid 16 3 16270640 (1), 16368680 (1)

    Search CenterWatch for drugs/clinical trials and news about TRPC5 

    Transcripts
    for TRPC5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TRPC5 gene: 
    NM_012471.2  

    Unigene Cluster for TRPC5:

    Transient receptor potential cation channel, subfamily C, member 5
    Hs.657709  [show with all ESTs]
    Unigene Representative Sequence: NM_012471
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000262839(uc004epl.1 uc004epm.1)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: TRPC5
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRPC5
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate TRPC5 (see all 28):
    hsa-miR-607 hsa-miR-1288 hsa-miR-4251 hsa-miR-216b hsa-miR-3921 hsa-miR-548a-3p hsa-miR-183* hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmid: TRPC5 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRPC5 (see all 7)
    OriGene shRNA RFP: TRPC5
    OriGene siRNA: TRPC5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRPC5
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRPC5 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRPC5
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TRPC5 (NM_012471)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRPC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPC5 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRPC5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRPC5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRPC5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRPC5

    Additional cDNA sequence: 

    AB209258.1 AF054568.1 BC137271.1 BC137274.1 

    2 DOTS entries:

    DT.92068222  DT.121284437 

    7 AceView cDNA sequences:

    BF438823 NM_012471 BX090656 AF054568 AI075962 BE169013 R73905 

    GeneLoc Exon Structure


    Expression
    for TRPC5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRPC5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAATTATAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TRPC5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Nkx2-1 GFP+ cells (Efficient derivation...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TRPC5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRPC5

    SOURCE GeneReport for Unigene cluster: Hs.657709

    UniProtKB/Swiss-Prot: TRPC5_HUMAN, Q9UL62
    Tissue specificity: Expressed in brain with higher levels in fetal brain. Found in cerebellum and occipital pole

        SABiosciences Custom PCR Arrays for TRPC5
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRPC5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRPC5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRPC5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRPC5
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC5

    Orthologs
    for TRPC5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TRPC5 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TRPC51 transient receptor potential cation channel, subfamily more 78.93(n)
    86.13(a)    		   422337  XM_420310.3  XP_420310.2 
    lizard
    (Anolis carolinensis)    		 Reptilia TRPC56
    		 --
    		 84(a)
    		 1 ↔ 1
    		 GL343376.1(529798-605859)
    zebrafish
    (Danio rerio)    		 Actinopterygii trpc5a6
    trpc5b6
    		 transient receptor potential cation channel, subfa...
    transient receptor potential cation channel, subfa...
    		 68(a)
    52(a)
    		 1 ↔ many
    1 ↔ many
    		 1(9662985-9796562)
    21(33098564-33177475)
    fruit fly
    (Drosophila melanogaster)    		 Insecta trp&ggr;3 calcium ion transport calcium channel 49(a)
    (best of 3)    		   36A9   --
    worm
    (Caenorhabditis elegans)    		 Secernentea trp-13 Transient-receptor-potential (trp) protein 39(a)   III(8607645-8614376)   --


    ENSEMBL Gene Tree for TRPC5 (if available)
    TreeFam Gene Tree for TRPC5 (if available) 

    Paralogs
    for TRPC5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRPC5 gene
    TRPC42  TRPC12  TRPC62  TRPC72  TRPC32  
    6 SIMAP similar genes for TRPC5 using alignment to 1 protein entry:     TRPC5_HUMAN:
    TRPC4    TRPC1    TRP7    TRPC6    TRPC3    TRPC7

    TRPC5 for paralogs           About GeneDecksing



    Genomic Variants
    for TRPC5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3875 NCBI SNPs in TRPC5 are shown (see all 3875)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1378710411,2
    		C,unknown111218988(+) TTAGCA/C/TGGGCG 1 -- int10--------
    rs735501701,2
    		C,--100944594(+) TGTGCC/TATGTC 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1846443271,2
    		--111017093(+) TACTTA/GATCAA 1 -- ds50010--------
    rs30277571,2
    		C,F,H,--111017222(-) ATTTAG/AGATGG 1 -- ds50018Minor allele frequency- A:0.04NS EA NA 902
    rs1894770131,2
    		--111017232(+) TGAGGC/TTTCAC 1 -- ds50010--------
    rs30277561,2
    		C,F,O,H,--111017367(-) GTTCTA/GAAGAG 1 -- ds50016Minor allele frequency- G:0.00NS EA NA 520
    rs1454815121,2
    		--111017461(+) ACTTAC/TAAGTT 1 -- ds50010--------
    rs1510567961,2
    		--111017609(+) AATTTG/TAAAAG 1 -- ut310--------
    rs1844381371,2
    		--111017889(+) AGGCTA/GGAGAC 1 -- ut310--------
    rs1905777381,2
    		--111017949(+) GTTTGA/GAGGCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TRPC5 (111017542 - 111267542 bp, first 250kb of TRPC5)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TRPC5: --
    Human Gene Mutation Database (HGMD): TRPC5

    Locus Specific Mutation Databases (LSDB): TRPC5

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRPC5
    DNA2.0 Custom Variant and Variant Library Synthesis for TRPC5

    Disorders / Diseases
    for TRPC5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TRPC5 for disorders           About GeneDecksing

    OMIM gene information: 300334    OMIM disorders: --

    11 diseases for TRPC5:    About MalaCards
    pyloric stenosis    hypertrophic pyloric stenosis    essential hypertension    pseudohypoaldosteronism
    hypercalciuria    hypertension    gingivitis    cerebritis
    neuronitis    carcinoma    breast cancer

    2 Novoseek disease relationships for TRPC5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    essential hypertension 18.1 3 17351372 (3)
    mental retardation 16.2 3 10493832 (3)

    Human Genome Epidemiology (HuGE) Navigator: TRPC5 (1 document)

    Export disorders for TRPC5 gene to outside databases

    Publications
    for TRPC5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRPC5 gene, integrated from 9 sources (see all 80):
    (articles sorted by number of sources associating them with TRPC5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of TRPC5 (HTRP5), the human homologue of a mouse brain receptor-activated capacitative Ca(2+) entry channel. (PubMed id 10493832)1, 2, 3, 9 Sossey-Alaoui K.... Srivastava A.K. (1999)
    2. The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5. (PubMed id 20164195)1, 2, 9 Miehe S....Strubing C. (2010)
    3. Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells. (PubMed id 16284075)1, 2 Shimizu S....Mori Y. (2006)
    4. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    5. MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC. (PubMed id 15757897)1, 2 Lussier M.P....Boulay G. (2005)
    6. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. (PubMed id 16382100)1, 3 Clapham D.E....Schultz G. (2005)
    7. Subunit composition of mammalian transient receptor potential channels in living cells. (PubMed id 12032305)1, 2 Hofmann T.... Gudermann T. (2002)
    8. Molecular determinant of sensing extracellular pH in classical transient receptor potential channel 5. (PubMed id 17981154)1, 9 Kim M.J....So I. (2008)
    9. Potentiation of TRPC5 by protons. (PubMed id 17884814)1, 9 Semtner M....Plant T.D. (2007)
    10. Sensing of lysophospholipids by TRPC5 calcium channel. (PubMed id 16368680)1, 9 Flemming P.K....Beech D.J. (2006)

    External Searches for TRPC5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TRPC5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7224 HGNC: 12337 AceView: TRPC5 Ensembl:ENSG00000072315 euGenes: HUgn7224
    ECgene: TRPC5 H-InvDB: TRPC5

    Other Databases showing TRPC5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TRPC5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRPC5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TRPC5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TRPC5 gene:
    Search GeneIP for patents involving TRPC5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for TRPC5 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of TRPC5
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for TRPC5   OriGene shRNA RFP for TRPC5  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRPC5   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRPC5  
     OriGene Protein Over-expression Lysate for TRPC5   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for TRPC5   OriGene 3'-UTR Clone for TRPC5  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRPC5   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRPC5  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TRPC5   OriGene Custom Protein Services for TRPC5  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRPC5
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRPC5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRPC5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRPC5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRPC5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRPC5
     GenScript Custom Purified and Recombinant Proteins Services for TRPC5 GenScript cDNA clones with any tag delivered in your preferred vector for TRPC5
     GenScript Custom Assay Services for TRPC5 GenScript Custom Superior Antibodies Services for TRPC5
     GenScript Custom overexpressing Cell Line Services for TRPC5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TRPC5 promoter
     Search Chromatin IP Primers for TRPC5
     RT2 qPCR Primer Assay in human, mouse, rat TRPC5
     GNC Network for TRPC5
     SABiosciences PCR Arrays including human, mouse, rat TRPC5
     Search Tocris compounds for TRPC5
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TRPC5 antibodies
     TRPC5 proteins
     TRPC5 lysates
     Search for Antibodies for TRPC5 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for TRPC5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     TRPC5 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for TRPC5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC5
     SwitchGear 3'UTR luciferase reporter plasmids for TRPC5
     SwitchGear Promoter luciferase reporter plasmids for TRPC5
     ThermoFisher Antibodies for TRPC5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPC5
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      TRPC5 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4