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TRPC4AP Gene

protein-coding   GIFtS: 58
GCID: GC20M033590

Transient Receptor Potential Cation Channel, Subfamily C,...

(Previous name: chromosome 20 open reading frame 188)
(Previous symbol: C20orf188)
  See TRPC4AP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Transient Receptor Potential Cation Channel, Subfamily C, Member 4
Associated Protein1 2
     Chromosome 20 Open Reading Frame 1881
C20orf1881 2 3     Short Transient Receptor Potential Channel 4 Associated Protein2
Trp4-Associated Protein2 3     Short Transient Receptor Potential Channel 4-Associated Protein2
Trpc4-Associated Protein2 3     Tumor Necrosis Factor Receptor-Associated Ubiquitous Scaffolding And
Signaling Protein2
TRRP4AP2 3     Protein TAP13
TNF-Receptor Ubiquitous Scaffolding/Signaling Protein2 3     Protein TRUSS3
TRUSS2 5     

External Ids:    HGNC: 161811   Entrez Gene: 261332   Ensembl: ENSG000001009917   OMIM: 6084305   UniProtKB: Q8TEL63   
ORGUL members:         

Export aliases for TRPC4AP gene to outside databases

Previous GC identifers: GC20M034258 GC20M034305 GC20M033053 GC20M030368


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TRPC4AP Gene:
TRPC4AP (transient receptor potential cation channel, subfamily C, member 4 associated protein) is a protein-coding gene. Diseases associated with TRPC4AP include plantar fasciitis, and epididymo-orchitis. GO annotations related to this gene include phosphatase binding.

UniProtKB/Swiss-Prot: TP4AP_HUMAN, Q8TEL6
Function: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for
cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent
degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by
linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved
in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1

Gene Wiki entry for TRPC4AP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRPC4AP gene promoter:
         PPAR-gamma1   AP-1   RREB-1   ATF-2   PPAR-gamma2   c-Jun   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRPC4AP promoter sequence
   Search Chromatin IP Primers for TRPC4AP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRPC4AP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.22   Ensembl cytogenetic band:  20q11.22   HGNC cytogenetic band: 20q11.23

TRPC4AP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRPC4AP gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M033590:  view genomic region     (about GC identifiers)

Start:
33,590,207 bp from pter      End:
33,680,674 bp from pter
Size:
90,468 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TP4AP_HUMAN, Q8TEL6 (See protein sequence)
Recommended Name: Short transient receptor potential channel 4-associated protein  
Size: 797 amino acids; 90852 Da
Subunit: Constitutively associated with TNFRSF1A. Directly interacts with TRADD, TRAF2, CHUK, IKBKB and IKBKG.
Interacts with TRPC1, TRPC4 and TRPC5 (By similarity). Component of the DCX(TRUSS) E3 ubiquitin ligase complex,
at least composed of CUL4A, DDB1, TRPC4AP/TRUSS and RBX1. Interacts with MYC
Sequence caution: Sequence=BAB84932.1; Type=Frameshift; Positions=43;
Secondary accessions: E1P5Q1 Q96H82 Q9BVB8 Q9H429 Q9UFS6
Alternative splicing: 2 isoforms:  Q8TEL6-1   Q8TEL6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRPC4AP: NX_Q8TEL6

Explore proteomics data for TRPC4AP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys70, Lys275, Lys303, Lys426, Lys472, Lys557, Lys598
  • Modification sites at PhosphoSitePlus

  • See TRPC4AP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_056453.1  NP_955400.1  

    ENSEMBL proteins: 
     ENSP00000400614   ENSP00000252015   ENSP00000400497   ENSP00000446090  
    Reactome Protein details: Q8TEL6

    TRPC4AP Human Recombinant Protein Products:

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    antibodies-online proteins for TRPC4AP (6 products) 

     
    antibodies-online peptides for TRPC4AP

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR022162 DUF3689
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q8TEL6

    ProtoNet protein and cluster: Q8TEL6


    Find genes that share domains with TRPC4AP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TP4AP_HUMAN, Q8TEL6
    Function: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for
    cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent
    degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by
    linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved
    in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI19389623
    GO:0019902phosphatase binding IDA19389623
         
    Find genes that share ontologies with TRPC4AP           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TRPC4AP:
     Increased homologous recombina 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Trpc4ap):
     cardiovascular system  integument  mortality/aging  vision/eye 

    Find genes that share phenotypes with TRPC4AP           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TRPC4AP

    miRNA
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    miRTarBase miRNAs that target TRPC4AP:
    hsa-mir-324-5p (MIRT043134), hsa-mir-320b (MIRT036238), hsa-mir-93-5p (MIRT048897), hsa-mir-106b-5p (MIRT044247)

    Block miRNA regulation of human, mouse, rat TRPC4AP using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate TRPC4AP:
    hsa-miR-142-5p hsa-miR-569 hsa-miR-136 hsa-miR-196a* hsa-miR-561 hsa-miR-486-3p hsa-miR-633 hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidTRPC4AP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TRPC4AP

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion2
    cytoskeleton1
    cytosol1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0031464Cul4A-RING ubiquitin ligase complex IDA--

    Find genes that share ontologies with TRPC4AP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TRPC4AP About    
    See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    3TRP channels
    TRP channels
    4TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway


    Find genes that share SuperPaths with TRPC4AP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for TRPC4AP
        TNF-alpha/NF-kB Signaling Pathway

    1 Reactome Pathway for TRPC4AP
        TRP channels


    UniProtKB/Swiss-Prot: TP4AP_HUMAN, Q8TEL6
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRPC4AP
    Interactions:

        GeneGlobe Interaction Network for TRPC4AP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRPC4AP (Q8TEL61, 2, 3 ENSP000002520154) via UniProtKB, MINT, STRING, and/or I2D (see all 32)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAB1Q157502, 3MINT-8260372 I2D: score=2 
    TRAF2Q129332, 3, ENSP000002476684MINT-2844904 I2D: score=5 STRING: ENSP00000247668
    CHUKO151113, ENSP000003594244I2D: score=4 STRING: ENSP00000359424
    TRADDQ156283, ENSP000003412684I2D: score=4 STRING: ENSP00000341268
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IDA--
    GO:0016567protein ubiquitination IEA--
    GO:0034220ion transmembrane transport TAS--
    GO:0055085transmembrane transport TAS--
    GO:0070588calcium ion transmembrane transport TAS--

    Find genes that share ontologies with TRPC4AP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRPC4AP (TP4AP)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRPC4AP gene (2 alternative transcripts): 
    NM_015638.2  NM_199368.1  

    Unigene Cluster for TRPC4AP:

    Transient receptor potential cation channel, subfamily C, member 4 associated protein
    Hs.168073  [show with all ESTs]
    Unigene Representative Sequence: AL096738
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000451813(uc021wci.1) ENST00000252015(uc002xbj.3 uc010zuq.2 uc002xbk.3 uc002xbl.3 uc010zur.2 uc002xbm.1)
    ENST00000432634 ENST00000539834
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate TRPC4AP:
    hsa-miR-142-5p hsa-miR-569 hsa-miR-136 hsa-miR-196a* hsa-miR-561 hsa-miR-486-3p hsa-miR-633 hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidTRPC4AP 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat TRPC4AP

    Additional mRNA sequence: 

    AF055022.1 AK298958.1 AK301368.1 AK303476.1 AK315582.1 AL096738.1 AL117480.1 BC001323.1 
    BC008836.2 BC013144.1 

    Selected DOTS entries (see all 29):

    DT.95283933  DT.100713594  DT.100799848  DT.100840462  DT.100814183  DT.451916  DT.100814187  DT.120802388 
    DT.91755284  DT.95167416  DT.120802331  DT.120802363  DT.120802435  DT.120802438  DT.86858517  DT.87014885 
    DT.100038345  DT.120802358  DT.40311405  DT.75151217  DT.120802343  DT.120802368  DT.120802378  DT.120802416 

    Selected AceView cDNA sequences (see all 72):

    BX281886 BF926901 BC069406 BC069327 AJ709100 CD244305 AB040945 AU117776 
    BF348318 AI160292 BG189675 BG210297 BM723903 AW206885 BC007808 AK000947 
    BX413650 BG219246 AI638757 BG218249 AW078595 BG189104 AI968301 BE672319 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TRPC4AP (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b
    SP1:                                                                    -     -     -                     
    SP2:                          -           -                                                               
    SP3:                                                                                                      
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for TRPC4AP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRPC4AP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCCCTTCC
    TRPC4AP Expression
    About this image

    TRPC4AP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRPC4AP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.168073
        Custom PCR Arrays for TRPC4AP
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC4AP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TRPC4AP gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trpc4ap1 , 5 transient receptor potential cation channel, subfamily more1, 5 91.55(n)1
    97.62(a)1
      2 (77.26 cM)5
    564071  NM_001163452.11  NP_001156924.11 
     1556342715 
    chicken
    (Gallus gallus)
    Aves TRPC4AP1 transient receptor potential cation channel, subfamily more 77.45(n)
    85.32(a)
      428134  NM_001039317.1  NP_001034406.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRPC4AP6
    transient receptor potential cation channel, subfa...
    79(a)
    1 ↔ 1
    4(135478144-135505838)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.226422 Xenopus laevis transcribed sequence with moderate similarity more 77.25(n)    CA791514.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tap1a2 trp4-associated protein 1a 78.66(n)   58090  AF130459.1 


    ENSEMBL Gene Tree for TRPC4AP (if available)
    TreeFam Gene Tree for TRPC4AP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRPC4AP (see all 2105)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1408480501,2
    --33590826(+) AAGCCC/TGTACC 2 -- ut310--------
    rs1850464451,2
    --33590910(+) CTCACC/TCACAC 2 -- ut310--------
    rs1997253791,2
    --33590915(+) CCACAC/TTGGCC 2 -- ut310--------
    rs1878074961,2
    --33590997(+) TCAATA/GTAGCT 4 Y syn10--------
    rs2013402811,2
    --33591005(+) GCTAAC/TGAGAG 4 I V mis10--------
    rs1180407731,2
    C,F--33591006(+) CTAACG/AAGAGC 4 /L syn13Minor allele frequency- A:0.00EA NA EU 5885
    rs1177291081,2
    C,F--33591013(+) GAGCAG/CAGGGT 4 /S /C mis11Minor allele frequency- C:0.04EA 120
    rs170922081,2
    C,F,H--33591030(+) CGGTCC/TGGGTT 4 P syn1 ese318Minor allele frequency- T:0.07NA NS EA WA CSA 6060
    rs1474995551,2
    C,F--33591034(+) CCGGGT/CTCAAC 4 /N /S mis11Minor allele frequency- C:0.00NA 4552
    rs599095201,2
    C--33591107(+) GGGGG-/GCGCCT 2 -- int10--------

    HapMap Linkage Disequilibrium report for TRPC4AP (33590207 - 33680674 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TRPC4AP (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2618405CNV Deletion19546169
    esv1332184CNV Deletion17803354
    esv993031CNV Deletion20482838
    esv2294766CNV Deletion18987734
    esv2722363CNV Deletion23290073
    esv3757CNV Deletion18987735
    esv2722360CNV Deletion23290073
    esv2722358CNV Deletion23290073
    esv2722359CNV Deletion23290073
    nsv3362CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608430    OMIM disorders: --

    5 diseases for TRPC4AP:    
    About MalaCards
    plantar fasciitis    epididymo-orchitis    elephantiasis    intestinal perforation
    orchitis

    4 diseases from the University of Copenhagen DISEASES database for TRPC4AP:
    epididymo-orchitis     Plantar fasciitis     Elephantiasis     Intestinal perforation

    Find genes that share disorders with TRPC4AP           About GenesLikeMe

    Genetic Association Database (GAD): TRPC4AP
    Human Genome Epidemiology (HuGE) Navigator: TRPC4AP (2 documents)

    Export disorders for TRPC4AP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for TRPC4AP gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with TRPC4AP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells. (PubMed id 20551172)1, 2 Choi S.H.... Cole M.D. (Genes Dev. 2010)
    2. The frequency of the TRPC4AP haplotype in Alzheimer's patients. (PubMed id 19059308)1, 4 Poduslo S.E....Huang J. (Neurosci. Lett. 2009)
    3. Genome screen of late-onset Alzheimer's extended pedigrees identifies TRPC4AP by haplotype analysis. (PubMed id 18449908)1, 4 Poduslo S.E....Smith S. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PubMed id 12693554)1, 2 Jikuya H....Ohara O. (DNA Res. 2003)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    7. TRUSS, a tumor necrosis factor receptor-1-interacting protein, activates c-Jun NH(2)-terminal kinase and transcription factor AP-1. (PubMed id 16876162)1, 9 Soond S.M....Riches D.W. (FEBS Lett. 2006)
    8. Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease. (PubMed id 22703881)1 Tang W....Folsom A.R. (Am. J. Hum. Genet. 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 26133 HGNC: 16181 AceView: MYH7B Ensembl:ENSG00000100991 euGenes: HUgn26133
    ECgene: TRPC4AP H-InvDB: TRPC4AP

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TRPC4AP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TRPC4AP gene:
    Search GeneIP for patents involving TRPC4AP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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