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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRPC4AP Gene

protein-coding   GIFtS: 54
GCID: GC20M033590

transient receptor potential cation channel, subfamily C,...

(Previous name: chromosome 20 open reading frame 188 )
(Previous symbol: C20orf188)
 Explore 9 diseases affiliated with
TRPC4AP via our new
 Human Malady Compendium 
Biological research products
for TRPC4AP
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Transient Receptor Potential Cation Channel, Subfamily C, Member 4
Associated Protein1 2
     DKFZp586C12231
C20orf1881 2 3     Chromosome 20 Open Reading Frame 1881
TRRP4AP1 2 3     DJ756N5.21
Trp4-Associated Protein2 3     Short Transient Receptor Potential Channel 4 Associated Protein2
Trpc4-Associated Protein2 3     Short Transient Receptor Potential Channel 4-Associated Protein2
TNF-Receptor Ubiquitous Scaffolding/Signaling Protein2 3     Tumor Necrosis Factor Receptor-Associated Ubiquitous Scaffolding And Signaling
Protein2
TRUSS2 5     Protein TAP13
DKFZP727M2311     Protein TRUSS3

External Ids:    HGNC: 161811   Entrez Gene: 261332   Ensembl: ENSG000001009917   OMIM: 6084305   UniProtKB: Q8TEL63   

Export aliases for TRPC4AP gene to outside databases

Previous GC identifers: GC20M034258 GC20M034305 GC20M033053 GC20M030368


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TP4AP_HUMAN, Q8TEL6
Function: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell
cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC.
Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the
IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic
reticulum Ca(2+) storage reduction in response to CHRM1

Gene Wiki entry for TRPC4AP


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRPC4AP gene promoter:
         PPAR-gamma1   AP-1   RREB-1   ATF-2   PPAR-gamma2   c-Jun   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRPC4AP promoter sequence
   Search SABiosciences Chromatin IP Primers for TRPC4AP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRPC4AP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.22   Ensembl cytogenetic band:  20q11.22   HGNC cytogenetic band: 20q11.23

TRPC4AP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRPC4AP gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M033590:  view genomic region     (about GC identifiers)

Start:
33,590,207 bp from pter      End:
33,680,674 bp from pter
Size:
90,468 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TP4AP_HUMAN, Q8TEL6 (See protein sequence)
Recommended Name: Short transient receptor potential channel 4-associated protein  
Size: 797 amino acids; 90852 Da
Subunit: Constitutively associated with TNFRSF1A. Directly interacts with TRADD, TRAF2, CHUK, IKBKB and IKBKG.
Interacts with TRPC1, TRPC4 and TRPC5 (By similarity). Component of the DCX(TRUSS) E3 ubiquitin ligase complex, at
least composed of CUL4A, DDB1, TRPC4AP/TRUSS and RBX1. Interacts with MYC
Sequence caution: Sequence=BAB84932.1; Type=Frameshift; Positions=43;
Secondary accessions: E1P5Q1 Q96H82 Q9BVB8 Q9H429 Q9UFS6
Alternative splicing: 2 isoforms:  Q8TEL6-1   Q8TEL6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRPC4AP: NX_Q8TEL6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8TEL6

  • TRPC4AP Protein expression data from MOPED and PaxDb:    About this image 
    TRPC4AP Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_056453.1  NP_955400.1  

    ENSEMBL proteins: 
     ENSP00000252015   ENSP00000400614   ENSP00000400497   ENSP00000446090  

    Human Recombinant Protein Products for TRPC4AP: 
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    Uscn Proteins for TRPC4AP

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031464Cul4A-RING ubiquitin ligase complex IDA--

    TRPC4AP for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TRPC4AP


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TRPC4AP for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR022162 DUF3689

    Graphical View of Domain Structure for InterPro Entry Q8TEL6

    ProtoNet protein and cluster: Q8TEL6


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TP4AP_HUMAN, Q8TEL6
    Function: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell
    cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC.
    Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the
    IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic
    reticulum Ca(2+) storage reduction in response to CHRM1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
    GO:0005515protein binding IPI19389623
    GO:0019902phosphatase binding IDA19389623
         
    TRPC4AP for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TRPC4AP:
     Increased homologous recombina 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Trpc4ap):
     cardiovascular system  integument  mortality/aging  vision/eye 

    TRPC4AP for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TRPC4AP 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidTRPC4AP 3' UTR sequence
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC4AP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway1.00


    1 BioSystems Pathway for TRPC4AP 
        TNF-alpha/NF-kB Signaling Pathway


    UniProtKB/Swiss-Prot: TP4AP_HUMAN, Q8TEL6
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRPC4AP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/32 Interacting proteins for TRPC4AP (Q8TEL61, 2, 3 ENSP000002520154) via UniProtKB, MINT, STRING, and/or I2D (see all 32)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAB1Q157502, 3MINT-8260372 I2D: score=2 
    TRAF2Q129332, 3, ENSP000002476684MINT-2844904 I2D: score=5 STRING: ENSP00000247668
    CHUKO151113, ENSP000003594244I2D: score=4 STRING: ENSP00000359424
    TRADDQ156283, ENSP000003412684I2D: score=4 STRING: ENSP00000341268
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IDA--
    GO:0016567protein ubiquitination IEA--

    TRPC4AP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRPC4AP
    Search CenterWatch for drugs/clinical trials and news about TRPC4AP / TP4AP 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRPC4AP gene (2 alternative transcripts): 
    NM_015638.2  NM_199368.1  

    Unigene Cluster for TRPC4AP:

    Transient receptor potential cation channel, subfamily C, member 4 associated protein
    Hs.168073  [show with all ESTs]
    Unigene Representative Sequence: AL096738
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000252015(uc002xbj.3 uc010zuq.2 uc002xbk.3 uc002xbl.3 uc010zur.2 uc002xbm.1)
    ENST00000451813(uc021wci.1) ENST00000432634 ENST00000539834

    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate TRPC4AP:
    hsa-miR-142-5p hsa-miR-569 hsa-miR-136 hsa-miR-196a* hsa-miR-561 hsa-miR-486-3p hsa-miR-633 hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidTRPC4AP 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: TRPC4AP
    OriGene siRNA: TRPC4AP
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    Sirion Biotech Custom design and validation of potent shRNA sequences against TRPC4AP 
    Clone
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    Additional cDNA sequence: 

    AF055022.1 AK298958.1 AK301368.1 AK303476.1 AK315582.1 AL096738.1 AL117480.1 BC001323.1 
    BC008836.2 BC013144.1 

    24/29 DOTS entries (see all 29):

    DT.95283933  DT.100713594  DT.100799848  DT.100840462  DT.100814183  DT.451916  DT.100814187  DT.120802388 
    DT.91755284  DT.95167416  DT.120802331  DT.120802363  DT.120802435  DT.120802438  DT.86858517  DT.87014885 
    DT.100038345  DT.120802358  DT.40311405  DT.75151217  DT.120802343  DT.120802368  DT.120802378  DT.120802416 

    24/72 AceView cDNA sequences (see all 72):

    BF926901 AJ709100 BC069327 CD244305 AU117776 BX281886 BC069406 AB040945 
    AI968301 AI638757 AW078595 BX413650 BE672319 BG189104 BG218249 BC007808 
    AW206885 BG210297 BG192213 BG219246 BM723903 AK000947 BF348318 BG189675 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TRPC4AP (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b
    SP1:                                                                    -     -     -                     
    SP2:                          -           -                                                               
    SP3:                                                                                                      
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for TRPC4AP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRPC4AP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGCCCTTCC
    TRPC4AP Expression
    About this image
    See TRPC4AP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRPC4AP

    SOURCE GeneReport for Unigene cluster: Hs.168073
        SABiosciences Custom PCR Arrays for TRPC4AP

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRPC4AP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC4AP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TRPC4AP gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trpc4ap1 , 5 transient receptor potential cation channel, subfamily more1, 5 91.55(n)1
    97.62(a)1
      2 (77.26 cM)5
    564071  NM_001163452.11  NP_001156924.11 
     1556342715 
    chicken
    (Gallus gallus)
    Aves TRPC4AP1 transient receptor potential cation channel, subfamily more 77.56(n)
    85.7(a)
      428134  NM_001039317.1  NP_001034406.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRPC4AP6
    --
    79(a)
    1 ↔ 1
    4(135478144-135505838)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.226422 Xenopus laevis transcribed sequence with moderate similarity more 77.25(n)    CA791514.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tap1a2 trp4-associated protein 1a 78.66(n)   58090  AF130459.1 


    ENSEMBL Gene Tree for TRPC4AP (if available)
    TreeFam Gene Tree for TRPC4AP (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1770 NCBI SNPs in TRPC4AP are shown (see all 1770    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs61422691,2
    C,H--30368251(+) GTGCAG/AGGGGA 1 -- int14Minor allele frequency- A:0.00NS EA 416
    rs60886711,2
    C,H--30368382(+) GCCACC/TTGCCC 1 -- ut314Minor allele frequency- T:0.00NS EA 420
    rs779660791,2
    C--30368450(+) TAAACA/CCCACA 1 -- ut310--------
    rs770633831,2
    C--30368453(+) ACACCA/CCAGCC 1 -- ut310--------
    rs1455766321,2
    C--33589722(+) CCAAGC/TGGAAC 3 -- int1 ds50011Minor allele frequency- T:0.00EU 941
    rs617450541,2
    C,F--33589927(+) GGGGGA/GCTGTG 3 -- int1 ds50014Minor allele frequency- G:0.02NS WA EU 1467
    rs1874103761,2
    C--33589992(+) AGTGAC/TGGCCT 3 -- ds5001 ut311Minor allele frequency- T:0.00EU 1323
    rs1427295341,2
    --33590034(+) TGTTGC/TACATC 3 -- ut31 ds50010--------
    rs49111671,2
    C,F,A,H--33590096(+) CCTTCG/AGCCTT 3 -- ds5001 ut3124Minor allele frequency- A:0.41NS EA NA WA CSA 2353
    rs1464194731,2
    --33590314(+) GGAGCA/GGCTGC 3 -- ut31 ds50010--------

    HapMap Linkage Disequilibrium report for TRPC4AP (33590207 - 33680674 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for TRPC4AP
         2 CNVs: 5134 102959
         4 Indels: 46092 26816 61927 43027

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TRPC4AP for disorders           About GeneDecksing

    OMIM gene information: 608430    OMIM disorders: --

    9 diseases for TRPC4AP:    About MalaCards
    epididymo-orchitis    plantar fasciitis    intestinal perforation    orchitis
    urethral obstruction    elephantiasis    hydrocele    fasciitis
    urethritis

    4 diseases from the University of Copenhagen DISEASES database for TRPC4AP:
    epididymo-orchitis     Plantar fasciitis     Elephantiasis     Intestinal perforation
    Human Genome Epidemiology (HuGE) Navigator: TRPC4AP (2 documents)

    Export disorders for TRPC4AP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRPC4AP gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with TRPC4AP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Myc protein is stabilized by suppression of a novel E 3 ligase complex in cancer cells. (PubMed id 20551172)1, 2 Choi S.H....Cole M.D. (2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PubMed id 12693554)1, 2 Jikuya H....Ohara O. (2003)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    5. TRUSS, a tumor necrosis factor receptor-1-interacting protein, activates c-Jun NH(2)-terminal kinase and transcription factor AP-1. (PubMed id 16876162)1, 9 Soond S.M....Riches D.W. (2006)
    6. Genetic associations for activated partial thromboplas tin time and prothrombin time, their gene expression profiles, and risk of coron ary artery disease. (PubMed id 22703881)1 Tang W....Folsom A.R. (2012)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26133 HGNC: 16181 AceView: MYH7B Ensembl:ENSG00000100991 euGenes: HUgn26133
    ECgene: TRPC4AP H-InvDB: TRPC4AP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRPC4AP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRPC4AP gene:
    Search GeneIP for patents involving TRPC4AP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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