Aliases for TRPC4 Gene
Aliases for TRPC4 Gene
External Ids for TRPC4 Gene
- HGNC: 12336
- Entrez Gene: 7223
- Ensembl: ENSG00000133107
- OMIM: 603651
- UniProtKB: Q9UBN4
Previous GeneCards Identifiers for TRPC4 Gene
- GC13M036197
- GC13M032197
- GC13M037147
- GC13M036008
- GC13M037108
- GC13M038210
- GC13M019010
Summaries for TRPC4 Gene
-
This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for TRPC4 Gene
TRPC4 (Transient Receptor Potential Cation Channel Subfamily C Member 4) is a Protein Coding gene. Diseases associated with TRPC4 include Photosensitive Epilepsy. Among its related pathways are Axon guidance and Ion channel transport. GO annotations related to this gene include ion channel activity and calcium channel activity. An important paralog of this gene is TRPC6.
UniProtKB/Swiss-Prot for TRPC4 Gene
-
Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.
-
The classical or canonical transient receptor potential (TRPC) channels are the subfamily most closely related to the founding member of the TRP family, the Drosophila TRP channel. TRPC channels have seven TRPC genes that encode the channel protein (TRPC1-7).
No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRPC4 Gene
Genomics for TRPC4 Gene
Regulatory Elements for TRPC4 Gene
Enhancers for TRPC4 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around TRPC4 on UCSC Golden Path with GeneCards custom track
Promoters for TRPC4 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around TRPC4 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the TRPC4 gene promoter:
Regulatory Element Products
Genomic Location for TRPC4 Gene
- Chromosome:
- 13
- Start:
- 37,633,872 bp from pter
- End:
- 37,870,425 bp from pter
- Size:
- 236,554 bases
- Orientation:
- Minus strand
Genomic View for TRPC4 Gene
Genes around TRPC4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 13q13.3 by Ensembl
- 13q13.3 by Entrez Gene
- 13q13.3 by HGNC
TRPC4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TRPC4 Gene
Proteins for TRPC4 Gene
-
Protein details for TRPC4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UBN4-TRPC4_HUMAN
- Recommended name:
- Short transient receptor potential channel 4
- Protein Accession:
- Q9UBN4
- B1ALE0
- B1ALE1
- B1ALE2
- Q15721
- Q3SWS6
- Q96P03
- Q96P04
- Q96P05
- Q9UIB0
- Q9UIB1
- Q9UIB2
Protein attributes for TRPC4 Gene
- Size:
- 977 amino acids
- Molecular mass:
- 112101 Da
- Quaternary structure:
-
- Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC1 and/or TRPC5. Isoform alpha but not isoform beta associates with inositol 1,4,5-trisphosphate receptor (ITPR). Interacts with (via PDZ-binding domain) with SLC9A3R1/NHERF. Interacts with MX1 and RNF24. Interacts (via CIRB domain) with SESTD1 (via spectrin 1 repeat). Interacts with CDH5 and CTNNB1. Interacts with SPTAN1 (via C-terminal spectrin repeats) and SPTBN5 (via C-terminus). Interacts (via protein 4.1-binding domain) with EPB41L2.
- Miscellaneous:
-
- The cell membrane presentation, the calcium entry function and the interaction with junctional proteins (CTNNB1 and CDH5) are controlled by endothelial cell-cell contacts.
- The interaction with spectrin is important in controlling the translocation of TRPC4 channels to the plasma membrane following EGF stimulation.
Protein Expression for TRPC4 Gene
Post-translational modifications for TRPC4 Gene
- Phosphorylation modulates TRPC channel function by regulating the level of TRPC4 at the cell surface and by increasing the association with SLC9A3R1/NHERF.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for TRPC4 Gene
Antibody Products
- Novus Biologicals Antibodies for TRPC4
- Invitrogen Antibodies for TRPC4
- antibodies-online Antibodies for TRPC4: See all 111
- GeneTex TRPC4 antibody for TRPC4
-
Santa Cruz Biotechnology (SCBT) Antibodies for TRPC4
Protein Products
-
OriGene Purified Proteins for TRPC4
- Search Origene for MassSpec and Protein Over-expression Lysates for TRPC4
- Origene Custom Protein Services for TRPC4
- Novus Biologicals proteins for TRPC4
- Search GeneTex for Proteins for TRPC4
Assay Products
No data available for DME Specific Peptides for TRPC4 Gene
Domains & Families for TRPC4 Gene
Gene Families for TRPC4 Gene
Protein Domains for TRPC4 Gene
Suggested Antigen Peptide Sequences for TRPC4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UBN4UniProtKB/Swiss-Prot:
TRPC4_HUMAN :- The protein 4.1-binding domain (654-685) is required for binding to EPB41L2 and channel activation.
- Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily.
- Contains 4 ANK repeats.
- Domain:
-
- The protein 4.1-binding domain (654-685) is required for binding to EPB41L2 and channel activation.
- The calmodulin- and inositol 1,4,5-trisphosphate receptor-binding (CIRB) domain (695-724) is sufficient for the interaction with SESTD1.
- The spectrin-binding domain (730-758) is required for binding to SPTAN1 and SPTBN5.
- Family:
-
- Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily.
- Similarity:
-
- Contains 4 ANK repeats.
Function for TRPC4 Gene
Molecular function for TRPC4 Gene
- UniProtKB/Swiss-Prot Function:
- Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.
Phenotypes for TRPC4 Gene
- MGI mutant phenotypes for TRPC4:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for TRPC4:
-
- shRNA abundance <= 50%
- Lamellipodia cells
- Decreased viability in esophageal squamous lineage
- Decreased ionizing radiation sensitivity
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased transferrin (TF) endocytosis
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Synthetic lethal with cisplatin
Animal Model Products
-
Taconic Biosciences Mouse Models for TRPC4
- Search ViGene Biosciences for TRPC4
CRISPR Products
-
OriGene CRISPR knockouts for TRPC4
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRPC4
- GenScript: Design CRISPR guide RNA sequences for TRPC4
miRNA for TRPC4 Gene
- miRTarBase miRNAs that target TRPC4
miRNA Products
- Search ViGene Biosciences for TRPC4
Inhibitory RNA Products
Clone Products
- OriGene clones in human for TRPC4
- OriGene ORF clones in human,mouse,rat for TRPC4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TRPC4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRPC4 Gene
Localization for TRPC4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TRPC4 Gene
- Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Enhanced insertion into the cell membrane after activation of the EGF receptor.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| plasma membrane | 5 |
| cytosol | 4 |
| endoplasmic reticulum | 2 |
| extracellular | 1 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | IBA | -- |
| GO:0005887 | integral component of plasma membrane | IBA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for TRPC4 Gene
More details on SuperPathways for TRPC4| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Developmental Biology |
.64
|
|
| 2 | Ion channel transport | ||
| 3 | Netrin-1 signaling | ||
| 4 | Axon guidance | ||
| 5 | CREB Pathway |
Pathways by source for TRPC4 Gene
8 Reactome pathways for TRPC4 Gene
1 KEGG pathway for TRPC4 Gene
1 Qiagen pathway for TRPC4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006828 | manganese ion transport | IBA | -- |
| GO:0007411 | axon guidance | TAS | -- |
| GO:0055085 | transmembrane transport | IEA | -- |
| GO:0070588 | calcium ion transmembrane transport | IEA,TAS | -- |
No data available for SIGNOR curated interactions for TRPC4 Gene
Drugs & Compounds for TRPC4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Niflumic Acid | Approved | Pharma | Channel blocker | Ca2+-activated Cl- channel blocker | 0 | |
| Flufenamic acid | Experimental | Pharma | Channel blocker | Activates TRPC6; NSAID | 0 | |
| 2-APB | Pharma | Antagonist, Pore Blocker | IP3 receptor antagonist. Also TRP channel modulator | 0 | ||
| La<sup>3+</sup> | Pharma | Pore Blocker | 0 | |||
| ML204 | Pharma | Channel blocker | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| GsMTx4 |
|
|
|
|||
| ML 204 |
|
5465-86-1 |
|
|
||
| SKF 96365 hydrochloride |
|
130495-35-1 |
|
|
(5) Tocris Compounds for TRPC4 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Flufenamic acid | Activates TRPC6; NSAID | 530-78-9 |
| GsMTx4 | TRPC1 and TRPC6 blocker; inhibits mechanosensitive ion channels | |
| ML 204 | Selective TRPC4 blocker | 5465-86-1 |
| Pyr3 | Selective TRPC3 blocker | 1160514-60-2 |
| SKF 96365 hydrochloride | TRPC channel blocker; also inhibits store-operated Ca2+ entry | 130495-35-1 |
(3) ApexBio Compounds for TRPC4 Gene
Drug Products
- ApexBio compounds for TRPC4
Transcripts for TRPC4 Gene
mRNA/cDNA for TRPC4 Gene
- (8) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (25) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TRPC4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TRPC4
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRPC4
- GenScript: Design CRISPR guide RNA sequences for TRPC4
miRNA Products
- Search ViGene Biosciences for TRPC4
Inhibitory RNA Products
Clone Products
- OriGene clones in human for TRPC4
- OriGene ORF clones in human,mouse,rat for TRPC4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TRPC4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||||
| SP8: | - | - |
Expression for TRPC4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
- GABAergic Amacrine Cells Inner Nuclear Layer
- Skeletal Muscle (Muscoskeletal System)
- Inner Cell Mass (Early Embryonic Tissues)
- Blood (Hematopoietic System)
- Mesenchymal Stem Cells
- Umbilical Cord (Extraembryonic Tissues)
-
Epithelial Cells
- Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
-
Neurons
- GABAergic Amacrine Cells Inner Nuclear Layer
- Smooth Muscle (Muscoskeletal System)
- Lung (Respiratory System)
mRNA differential expression in normal tissues according to GTEx for TRPC4 Gene
This gene is overexpressed in Uterus (x7.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRPC4 Gene
SOURCE GeneReport for Unigene cluster for TRPC4 Gene Hs.262960
mRNA Expression by UniProt/SwissProt for TRPC4 Gene
Q9UBN4-TRPC4_HUMAN
Tissue specificity:
Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Expressed in endothelial cells. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain.
Primer Products
-
OriGene qPCR primer pairs for TRPC4
No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for TRPC4 Gene
Orthologs for TRPC4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | TRPC4 35 |
|
||
| TRPC4 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | TRPC4 35 |
|
||
| TRPC4 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Trpc4 35 |
|
||
| Trpc4 16 |
|
||||
| Trpc4 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | TRPC4 35 |
|
||
| TRPC4 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Trpc4 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TRPC4 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | TRPC4 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TRPC4 35 |
|
||
| TRPC4 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | TRPC4 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | trpc4 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | Dr.24084 35 |
|
||
| trpc4 35 |
|
||||
| TRPC4 (2 of 2) 36 |
|
OneToMany | |||
| trpc4b 36 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | trp 37 |
|
|
|
| trpgamma 37 |
|
|
|||
| trpl 37 |
|
|
|||
| trpgamma 35 |
|
||||
| trp 36 |
|
ManyToMany | |||
| trpgamma 36 |
|
ManyToMany | |||
| trpl 36 |
|
ManyToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008435 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | trp-1 37 |
|
|
|
| trp-2 35 |
|
||||
| trp-2 36 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
ManyToMany |
- Species with no ortholog for TRPC4:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for TRPC4 Gene
(6) SIMAP similar genes for TRPC4 Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for TRPC4 Gene
Variants for TRPC4 Gene
| SNP ID | Clin | Chr 13 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_036452 | A breast cancer sample | ||||
| rs476995 | -- | 37,849,357(+) | AAGGA(A/T)GACTG | intron-variant | |
| rs601958 | -- | 37,812,627(-) | ttcca(C/T)agctt | intron-variant | |
| rs603955 | -- | 37,848,946(-) | TATAC(C/T)CAAGA | intron-variant | |
| rs604068 | -- | 37,799,256(+) | TAACA(C/T)CAACA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv34109 | CNV | Loss | 18971310 |
| esv259555 | OTHER | Complex | 20981092 |
| nsv64072 | CNV | Insertion | 16902084 |
| esv1262429 | CNV | Insertion | 17803354 |
| nsv64068 | CNV | Insertion | 16902084 |
| nsv826617 | CNV | Loss | 20364138 |
| esv33246 | CNV | Gain | 17666407 |
| esv2668113 | CNV | Deletion | 23128226 |
| nsv899995 | CNV | Loss | 21882294 |
| esv2661529 | CNV | Deletion | 23128226 |
| esv268730 | CNV | Insertion | 20981092 |
Residual Variation Intolerance Score:
6.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.08;
22.08% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for TRPC4 Gene
- Human Gene Mutation Database (HGMD)
- TRPC4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRPC4 Gene
Disorders for TRPC4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| photosensitive epilepsy |
|
|
Search TRPC4 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for TRPC4
No data available for UniProtKB/Swiss-Prot and Genatlas for TRPC4 Gene
Publications for TRPC4 Gene
- trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. (PMID: 8646775) Zhu X. … Birnbaumer L. (Cell 1996) 2 3 4 67
- Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction. (PMID: 19996314) Graziani A. … Groschner K. (J. Biol. Chem. 2010) 3 23
- The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5. (PMID: 20164195) Miehe S. … Strubing C. (J. Biol. Chem. 2010) 3 23
- Interaction between TRPC1/TRPC4 assembly and STIM1 contributes to store-operated Ca2+ entry in mesangial cells. (PMID: 19307462) Sours-Brothers S. … Ma R. (Exp. Biol. Med. (Maywood) 2009) 3 23
- Evidence that TRPC4 supports the calcium selective I(CRAC)-like current in human gingival keratinocytes. (PMID: 17031666) Fatherazi S. … Izutsu K.T. (Pflugers Arch. 2007) 3 23
Products for TRPC4 Gene
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- Custom Antibody Services
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- OriGene Purified Proteins for TRPC4
- Search Origene for MassSpec and Protein Over-expression Lysates for TRPC4
- Origene Custom Protein Services for TRPC4
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for TRPC4
- Browse OriGene Inhibitory RNA Products For TRPC4
- OriGene qPCR primer pairs for TRPC4
- OriGene CRISPR knockouts for TRPC4
- OriGene clones in human for TRPC4
- OriGene ORF clones in human,mouse,rat for TRPC4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for TRPC4
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- GenScript: Design CRISPR guide RNA sequences for TRPC4
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for TRPC4
- Novus Biologicals Antibodies for TRPC4
- Novus Biologicals proteins for TRPC4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Taconic Biosciences Mouse Models for TRPC4
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for TRPC4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for TRPC4
- Search ViGene Biosciences for TRPC4
- Search ViGene Biosciences for TRPC4
- Santa Cruz Biotechnology (SCBT) Antibodies for TRPC4
- Search Santa Cruz Biotechnology (SCBT) for TRPC4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TRPC4
Sources for TRPC4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
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