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Aliases for TRPC4 Gene

Aliases for TRPC4 Gene

  • Transient Receptor Potential Cation Channel, Subfamily C, Member 4 2 3
  • Trp-Related Protein 4 3 4
  • HTRP-4 3 4
  • HTRP4 3 4
  • TRP4 3 6
  • Short Transient Receptor Potential Channel 4 3
  • TrpC4 4

External Ids for TRPC4 Gene

Summaries for TRPC4 Gene

Entrez Gene Summary for TRPC4 Gene

  • This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for TRPC4 Gene

TRPC4 (Transient Receptor Potential Cation Channel, Subfamily C, Member 4) is a Protein Coding gene. Among its related pathways are L1CAM interactions and CREB Pathway. GO annotations related to this gene include beta-catenin binding and store-operated calcium channel activity. An important paralog of this gene is TRPC6.

UniProtKB/Swiss-Prot for TRPC4 Gene

  • Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.

Tocris Summary for TRPC4 Gene

  • The classical or canonical transient receptor potential (TRPC) channels are the subfamily most closely related to the founding member of the TRP family, the Drosophila TRP channel. TRPC channels have seven TRPC genes that encode the channel protein; these are named TRPC1-7 (TRPC2 is a pseudogene in humans). They are non-selective, calcium permeable cation channels; however their permeability ratio of calcium/sodium ions varies between different members of the family. Generally, TRPC channels can be activated by phospholipase C, with some members (TRPC3, -6 and -7) being activated directly by diacylglycerol (DAG).

Gene Wiki entry for TRPC4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRPC4 Gene

Genomics for TRPC4 Gene

Genomic Location for TRPC4 Gene

Start:
37,636,636 bp from pter
End:
37,870,425 bp from pter
Size:
233,790 bases
Orientation:
Minus strand

Genomic View for TRPC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRPC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRPC4 Gene

Regulatory Elements for TRPC4 Gene

Proteins for TRPC4 Gene

  • Protein details for TRPC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBN4-TRPC4_HUMAN
    Recommended name:
    Short transient receptor potential channel 4
    Protein Accession:
    Q9UBN4
    Secondary Accessions:
    • B1ALE0
    • B1ALE1
    • B1ALE2
    • Q15721
    • Q3SWS6
    • Q96P03
    • Q96P04
    • Q96P05
    • Q9UIB0
    • Q9UIB1
    • Q9UIB2

    Protein attributes for TRPC4 Gene

    Size:
    977 amino acids
    Molecular mass:
    112101 Da
    Quaternary structure:
    • Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC1 and/or TRPC5. Isoform alpha but not isoform beta associates with inositol 1,4,5-trisphosphate receptor (ITPR). Interacts with (via PDZ-binding domain) with SLC9A3R1/NHERF. Interacts with MX1 and RNF24. Interacts (via CIRB domain) with SESTD1 (via spectrin 1 repeat). Interacts with CDH5 and CTNNB1. Interacts with SPTAN1 (via C-terminal spectrin repeats) and SPTBN5 (via C-terminus). Interacts (via protein 4.1-binding domain) with EPB41L2.
    Miscellaneous:
    • The cell membrane presentation, the calcium entry function and the interaction with junctional proteins (CTNNB1 and CDH5) are controlled by endothelial cell-cell contacts
    • The interaction with spectrin is important in controlling the translocation of TRPC4 channels to the plasma membrane following EGF stimulation

    Alternative splice isoforms for TRPC4 Gene

neXtProt entry for TRPC4 Gene

Proteomics data for TRPC4 Gene at MOPED

Post-translational modifications for TRPC4 Gene

  • Phosphorylation modulates TRPC channel function by regulating the level of TRPC4 at the cell surface and by increasing the association with SLC9A3R1/NHERF.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRPC4 Gene

Domains for TRPC4 Gene

Gene Families for TRPC4 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing
  • TRP :Voltage-gated ion channels / Transient receptor potential cation channels
IUPHAR :

UniProtKB/Swiss-Prot:

TRPC4_HUMAN
Domain:
  • The protein 4.1-binding domain (654-685) is required for binding to EPB41L2 and channel activation:
    • Q9UBN4
  • The calmodulin- and inositol 1,4,5-trisphosphate receptor-binding (CIRB) domain (695-724) is sufficient for the interaction with SESTD1:
    • Q9UBN4
  • The spectrin-binding domain (730-758) is required for binding to SPTAN1 and SPTBN5:
    • Q9UBN4
Family:
  • Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily.:
    • Q9UBN4
Similarity:
  • Contains 4 ANK repeats.:
    • Q9UBN4
genes like me logo Genes that share domains with TRPC4: view

Function for TRPC4 Gene

Molecular function for TRPC4 Gene

UniProtKB/Swiss-Prot Function: Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.

Gene Ontology (GO) - Molecular Function for TRPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005262 calcium channel activity --
GO:0005515 protein binding IPI 15757897
GO:0008013 beta-catenin binding IPI 19996314
GO:0015279 store-operated calcium channel activity IMP 16254212
genes like me logo Genes that share ontologies with TRPC4: view
genes like me logo Genes that share phenotypes with TRPC4: view

Animal Models for TRPC4 Gene

MGI Knock Outs for TRPC4:

miRNA for TRPC4 Gene

miRTarBase miRNAs that target TRPC4

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TRPC4 Gene

Localization for TRPC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRPC4 Gene

Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Enhanced insertion into the cell membrane after activation of the EGF receptor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRPC4 Gene COMPARTMENTS Subcellular localization image for TRPC4 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
endoplasmic reticulum 2
cytosol 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TRPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0005901 caveola IEA --
GO:0005911 colocalizes_with cell-cell junction IDA 19996314
GO:0009986 cell surface IDA 19996314
genes like me logo Genes that share ontologies with TRPC4: view

Pathways for TRPC4 Gene

genes like me logo Genes that share pathways with TRPC4: view

Pathways by source for TRPC4 Gene

Interacting Proteins for TRPC4 Gene

Gene Ontology (GO) - Biological Process for TRPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0006816 calcium ion transport TAS 8646775
GO:0006828 manganese ion transport IBA --
GO:0007411 axon guidance TAS --
GO:0014051 gamma-aminobutyric acid secretion IEA --
genes like me logo Genes that share ontologies with TRPC4: view

Compounds for TRPC4 Gene

(3) Tocris Compounds for TRPC4 Gene

Compound Action Cas Number
GsMTx4 TRPC1 and TRPC6 blocker; inhibits mechanosensitive ion channels
ML 204 Selective TRPC4 blocker [5465-86-1]
Pyr3 Selective TRPC3 channel blocker [1160514-60-2]

(1) HMDB Compounds for TRPC4 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(5) IUPHAR Ligand for TRPC4 Gene

Ligand Type Action Affinity Pubmed IDs
ML204 Channel blocker None 5.5
SKF96365 Channel blocker None
La3+ Channel blocker None
2-APB Channel blocker None
niflumic acid Channel blocker None

(9) Novoseek inferred chemical compound relationships for TRPC4 Gene

Compound -log(P) Hits PubMed IDs
1-oleoyl-2-acetyl-sn-glycerol 71.8 1
thapsigargin 70.8 3
calcium 58.4 21
inositol 1,4,5 trisphosphate 45 2
carbachol 37.4 4
genes like me logo Genes that share compounds with TRPC4: view

Transcripts for TRPC4 Gene

Unigene Clusters for TRPC4 Gene

Transient receptor potential cation channel, subfamily C, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRPC4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: -
SP2: - - -
SP3: -
SP4: - -
SP5: - -
SP6:
SP7: - -
SP8: - -

Relevant External Links for TRPC4 Gene

GeneLoc Exon Structure for
TRPC4
ECgene alternative splicing isoforms for
TRPC4

Expression for TRPC4 Gene

mRNA expression in normal human tissues for TRPC4 Gene

mRNA differential expression in normal tissues according to GTEx for TRPC4 Gene

This gene is overexpressed in Uterus (7.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TRPC4 Gene

SOURCE GeneReport for Unigene cluster for TRPC4 Gene Hs.262960

mRNA Expression by UniProt/SwissProt for TRPC4 Gene

Q9UBN4-TRPC4_HUMAN
Tissue specificity: Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Expressed in endothelial cells. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain.
genes like me logo Genes that share expressions with TRPC4: view

Orthologs for TRPC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRPC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRPC4 36
  • 99.93 (n)
  • 100 (a)
TRPC4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRPC4 36
  • 90.24 (n)
  • 97.13 (a)
TRPC4 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRPC4 36
  • 92.36 (n)
  • 98.16 (a)
TRPC4 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trpc4 36
  • 88.25 (n)
  • 97.33 (a)
Trpc4 16
Trpc4 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRPC4 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRPC4 37
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trpc4 36
  • 88.01 (n)
  • 97.23 (a)
chicken
(Gallus gallus)
Aves TRPC4 36
  • 79.12 (n)
  • 85.32 (a)
TRPC4 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRPC4 37
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trpc4 36
  • 74.99 (n)
  • 84.31 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.24084 36
trpc4 36
  • 70.8 (n)
  • 80.28 (a)
TRPC4 (2 of 2) 37
  • 71 (a)
OneToMany
trpc4b 37
  • 76 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008435 36
  • 56.49 (n)
  • 56.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta trp 37
  • 30 (a)
ManyToMany
trpgamma 36
  • 55.71 (n)
  • 55.66 (a)
trpgamma 37
  • 39 (a)
ManyToMany
trpl 37
  • 33 (a)
ManyToMany
trpgamma 38
  • 52 (a)
trpl 38
  • 45 (a)
trp 38
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea trp-2 36
  • 52.37 (n)
  • 48.24 (a)
trp-2 37
  • 42 (a)
OneToMany
trp-1 38
  • 41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 25 (a)
ManyToMany
Species with no ortholog for TRPC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRPC4 Gene

ENSEMBL:
Gene Tree for TRPC4 (if available)
TreeFam:
Gene Tree for TRPC4 (if available)

Paralogs for TRPC4 Gene

Paralogs for TRPC4 Gene

Selected SIMAP similar genes for TRPC4 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for TRPC4 Gene

genes like me logo Genes that share paralogs with TRPC4: view

Variants for TRPC4 Gene

Sequence variations from dbSNP and Humsavar for TRPC4 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs476995 -- 37,849,357(+) AAGGA(A/T)GACTG intron-variant
rs510376 -- 37,850,681(+) ATGTA(A/G)TGAAT intron-variant
rs535728 -- 37,851,104(+) TTAAA(A/G)AGTCA intron-variant
rs545636 -- 37,844,257(-) ctgta(A/G)tgtga intron-variant
rs584833 -- 37,814,118(-) gaatt(G/T)ctttg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRPC4 Gene

Variant ID Type Subtype PubMed ID
esv34109 CNV Loss 18971310
esv259555 OTHER Complex 20981092
nsv64072 CNV Insertion 16902084
esv1262429 CNV Insertion 17803354
nsv64068 CNV Insertion 16902084
nsv826617 CNV Loss 20364138
esv33246 CNV Gain 17666407
esv2668113 CNV Deletion 23128226
nsv899995 CNV Loss 21882294
esv2661529 CNV Deletion 23128226
esv268730 CNV Insertion 20981092

Relevant External Links for TRPC4 Gene

HapMap Linkage Disequilibrium report
TRPC4
Human Gene Mutation Database (HGMD)
TRPC4

Disorders for TRPC4 Gene

Relevant External Links for TRPC4

Genetic Association Database (GAD)
TRPC4
Human Genome Epidemiology (HuGE) Navigator
TRPC4
genes like me logo Genes that share disorders with TRPC4: view

No data available for UniProtKB/Swiss-Prot for TRPC4 Gene

Publications for TRPC4 Gene

  1. Cloning and expression of the human transient receptor potential 4 (TRP4) gene: localization and functional expression of human TRP4 and TRP3. (PMID: 11042129) McKay R.R. … Putney J.W. Jr. (Biochem. J. 2000) 3 4 23
  2. The PDZ-interacting domain of TRPC4 controls its localization and surface expression in HEK293 cells. (PMID: 12154080) Mery L. … Hoth M. (J. Cell Sci. 2002) 3 4 23
  3. Activation of the endothelial store-operated ISOC Ca2+ channel requires interaction of protein 4.1 with TRPC4. (PMID: 16254212) Cioffi D.L. … Stevens T. (Circ. Res. 2005) 3 4 23
  4. Functional differences between TRPC4 splice variants. (PMID: 11713258) Schaefer M. … Schultz G. (J. Biol. Chem. 2002) 3 4 23
  5. Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction. (PMID: 19996314) Graziani A. … Groschner K. (J. Biol. Chem. 2010) 3 4 23

Products for TRPC4 Gene

Sources for TRPC4 Gene

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