Aliases for TRPC4 Gene
Aliases for TRPC4 Gene
External Ids for TRPC4 Gene
- HGNC: 12336
- Entrez Gene: 7223
- Ensembl: ENSG00000133107
- OMIM: 603651
- UniProtKB: Q9UBN4
Previous GeneCards Identifiers for TRPC4 Gene
- GC13M036197
- GC13M032197
- GC13M037147
- GC13M036008
- GC13M037108
- GC13M038210
- GC13M019010
Summaries for TRPC4 Gene
-
This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for TRPC4 Gene
TRPC4 (Transient Receptor Potential Cation Channel Subfamily C Member 4) is a Protein Coding gene. Diseases associated with TRPC4 include Photosensitive Epilepsy. Among its related pathways are Developmental Biology and Netrin-1 signaling. Gene Ontology (GO) annotations related to this gene include ion channel activity and calcium channel activity. An important paralog of this gene is TRPC5.
UniProtKB/Swiss-Prot for TRPC4 Gene
-
Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.
-
The classical or canonical transient receptor potential (TRPC) channels are the subfamily most closely related to the founding member of the TRP family, the Drosophila TRP channel. TRPC channels have seven TRPC genes that encode the channel protein (TRPC1-7).
Additional gene information for TRPC4 Gene
- Monarch Initiative
- Search for TRPC4 at DataMed
- Search for TRPC4 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRPC4 Gene
Genomics for TRPC4 Gene
GeneHancer (GH) Regulatory Elements for TRPC4 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH13I037868 | Promoter/Enhancer | 1.8 | EPDnew Ensembl ENCODE | 550.8 | +0.5 | 497 | 2.8 | ZSCAN4 SIN3A RAD21 RFX5 ZNF335 GLIS2 SCRT2 ZNF143 EGR2 ZNF654 | TRPC4 GC13M037855 RNA5SP26 | |
GH13I037594 | Promoter/Enhancer | 1.8 | EPDnew Ensembl ENCODE dbSUPER | 4.9 | +273.4 | 273369 | 6.1 | POLR2A POU5F1 MNT | POSTN TRPC4 LINC00547 | |
GH13I037616 | Enhancer | 1 | FANTOM5 Ensembl ENCODE | 5 | +252.8 | 252836 | 3.1 | JUN CEBPB FEZF1 EP300 ZIC2 OSR2 SP1 JUND MAFF TCF7L2 | TRPC4 POSTN GC13P037655 | |
GH13I037914 | Enhancer | 0.4 | ENCODE | 11.5 | -44.5 | -44531 | 1.6 | SP1 ZNF680 | TRPC4 LINC00571 GC13P037919 | |
GH13I037601 | Enhancer | 0.6 | ENCODE dbSUPER | 5.3 | +268.4 | 268431 | 1.3 | CTCF ATF2 | POSTN TRPC4 GC13P037655 |
Regulatory Element Products
Genomic Locations for TRPC4 Gene
- chr13:37,633,872-37,870,425
- (GRCh38/hg38)
- Size:
- 236,554 bases
- Orientation:
- Minus strand
- chr13:38,210,773-38,444,562
- (GRCh37/hg19)
Genomic View for TRPC4 Gene
- Cytogenetic band:
-
- 13q13.3 by Ensembl
- 13q13.3 by Entrez Gene
- 13q13.3 by HGNC


RefSeq DNA sequence for TRPC4 Gene
Proteins for TRPC4 Gene
-
Protein details for TRPC4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UBN4-TRPC4_HUMAN
- Recommended name:
- Short transient receptor potential channel 4
- Protein Accession:
- Q9UBN4
- B1ALE0
- B1ALE1
- B1ALE2
- Q15721
- Q3SWS6
- Q96P03
- Q96P04
- Q96P05
- Q9UIB0
- Q9UIB1
- Q9UIB2
Protein attributes for TRPC4 Gene
- Size:
- 977 amino acids
- Molecular mass:
- 112101 Da
- Quaternary structure:
-
- Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC1 and/or TRPC5. Isoform alpha but not isoform beta associates with inositol 1,4,5-trisphosphate receptor (ITPR). Interacts with (via PDZ-binding domain) with SLC9A3R1/NHERF. Interacts with MX1 and RNF24. Interacts (via CIRB domain) with SESTD1 (via spectrin 1 repeat). Interacts with CDH5 and CTNNB1. Interacts with SPTAN1 (via C-terminal spectrin repeats) and SPTBN5 (via C-terminus). Interacts (via protein 4.1-binding domain) with EPB41L2.
- Miscellaneous:
-
- The cell membrane presentation, the calcium entry function and the interaction with junctional proteins (CTNNB1 and CDH5) are controlled by endothelial cell-cell contacts.
- The interaction with spectrin is important in controlling the translocation of TRPC4 channels to the plasma membrane following EGF stimulation.
Protein Expression for TRPC4 Gene
Post-translational modifications for TRPC4 Gene
- Phosphorylation modulates TRPC channel function by regulating the level of TRPC4 at the cell surface and by increasing the association with SLC9A3R1/NHERF.
Other Protein References for TRPC4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for TRPC4
- Novus Biologicals Antibodies for TRPC4
-
Abcam antibodies for TRPC4
- Invitrogen Antibodies for TRPC4
- GeneTex TRPC4 antibody for TRPC4
Protein Products
-
OriGene Purified Proteins for TRPC4
- Search Origene for MassSpec and Protein Over-expression Lysates for TRPC4
- Origene Custom Protein Services for TRPC4
- antibodies-online: Search results for 6 available TRPC4 Proteins ranked by validation data
- Compare Top TRPC4 Proteins
-
Quality Products:
- Search GeneTex for Proteins for TRPC4
Assay Products
No data available for DME Specific Peptides for TRPC4 Gene
Domains & Families for TRPC4 Gene
Gene Families for TRPC4 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted membrane proteins
- Transporters
- Voltage-gated ion channels
Protein Domains for TRPC4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for TRPC4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UBN4UniProtKB/Swiss-Prot:
TRPC4_HUMAN :- The protein 4.1-binding domain (654-685) is required for binding to EPB41L2 and channel activation.
- Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily.
- Domain:
-
- The protein 4.1-binding domain (654-685) is required for binding to EPB41L2 and channel activation.
- The calmodulin- and inositol 1,4,5-trisphosphate receptor-binding (CIRB) domain (695-724) is sufficient for the interaction with SESTD1.
- The spectrin-binding domain (730-758) is required for binding to SPTAN1 and SPTBN5.
- Family:
-
- Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily.
Function for TRPC4 Gene
Molecular function for TRPC4 Gene
- UniProtKB/Swiss-Prot Function:
- Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.
Phenotypes From GWAS Catalog for TRPC4 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005262 | calcium channel activity | TAS,IEA | -- |
GO:0005515 | protein binding | IPI | 15757897 |
GO:0008013 | beta-catenin binding | IPI | 19996314 |
GO:0015279 | store-operated calcium channel activity | IMP | 16254212 |
GO:0045296 | cadherin binding | IPI | 19996314 |
Phenotypes for TRPC4 Gene
- MGI mutant phenotypes for TRPC4:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for TRPC4:
-
- shRNA abundance <= 50%
- Lamellipodia cells
- Decreased viability in esophageal squamous lineage
- Decreased ionizing radiation sensitivity
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased transferrin (TF) endocytosis
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Synthetic lethal with cisplatin
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TRPC4
-
- Search ViGene Biosciences for TRPC4
CRISPR Products
-
OriGene CRISPR knockouts for TRPC4
- genomics-online: gRNA clones - Search results for 155 available TRPC4 gene related products
- Overview of 155 available TRPC4 gene related products
-
Recommended
- Applied Biological Materials CRISPR for TRPC4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRPC4
- GenScript: Design CRISPR guide RNA sequences for TRPC4
miRNA for TRPC4 Gene
- miRTarBase miRNAs that target TRPC4
miRNA Products
- Search ViGene Biosciences for TRPC4
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TRPC4
- Browse OriGene Inhibitory RNA Products For TRPC4
- genomics-online: shRNA clones - Search results for 155 available TRPC4 gene related products
- Overview of 155 available TRPC4 gene related products
-
Recommended
Clone Products
-
OriGene ORF clones in human for TRPC4
- RC226709L1V
- RC226709L2V
- RC226715L1V
- RC226715L2V
- RC226722L1V
- RC226722L2V
- RC226733L1V
- RC226733L2V
- RC226703L1V
- RC226703L2V
- RC218941L1V
- RC218941L2V
- RC226709
- RC226709L1
- RC226709L2
- RG226709
- RC226715
- RC226715L1
- RC226715L2
- RG226715
- RC226722
- RC226722L1
- RC226722L2
- RG226722
- RC226733
- RC226733L1
- RC226733L2
- RG226733
- RC226703
- RC226703L1
- RC226703L2
- RG226703
- RC218941
- RC218941L1
- RC218941L2
- RG218941
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TRPC4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TRPC4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TRPC4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 155 available TRPC4 gene related products
- Overview of 155 available TRPC4 gene related products
-
Recommended
- orf clones - Search results for 155 available TRPC4 gene related products
- Overview of 155 available TRPC4 gene related products
-
Recommended
- Applied Biological Materials Clones for TRPC4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TRPC4
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRPC4 Gene
Localization for TRPC4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TRPC4 Gene
- Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Enhanced insertion into the cell membrane after activation of the EGF receptor.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | IBA | -- |
GO:0005901 | caveola | IEA | -- |
GO:0005911 | colocalizes_with cell-cell junction | IDA | 19996314 |
GO:0009986 | cell surface | IDA | 19996314 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for TRPC4 Gene
Pathways & Interactions for TRPC4 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Developmental Biology |
.51
|
|
2 | Ion channel transport | ||
3 | Netrin-1 signaling | ||
4 | Axon guidance | ||
5 | CREB Pathway |
Pathways by source for TRPC4 Gene
8 Reactome pathways for TRPC4 Gene
1 KEGG pathway for TRPC4 Gene
1 Qiagen pathway for TRPC4 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006810 | transport | IEA | -- |
GO:0006811 | ion transport | IEA | -- |
GO:0006816 | calcium ion transport | TAS | 8646775 |
GO:0006828 | manganese ion transport | IBA | -- |
GO:0014051 | gamma-aminobutyric acid secretion | IEA | -- |
No data available for SIGNOR curated interactions for TRPC4 Gene
Drugs & Compounds for TRPC4 Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
calcium | Approved | Nutra | 0 | |||
Niflumic Acid | Approved | Pharma | Channel blocker | Ca2+-activated Cl- channel blocker | 0 | |
SKF 96365 hydrochloride | Pharma | SOCE inhibitor, TRPC channel blocker; also inhibits store-operated Ca2+ entry | 0 | |||
2-APB | Pharma | Antagonist, Pore Blocker | IP3 receptor antagonist. Also TRP channel modulator | 0 | ||
La<sup>3+</sup> | Pharma | Pore Blocker | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
(3) Tocris Compounds for TRPC4 Gene
Compound | Action | Cas Number |
---|---|---|
Clemizole hydrochloride | TRPC5 blocker; also H1 antagonist | 1163-36-6 |
Pyr3 | Selective TRPC3 blocker | 1160514-60-2 |
SKF 96365 hydrochloride | TRPC channel blocker; also inhibits store-operated Ca2+ entry | 130495-35-1 |
(4) ApexBio Compounds for TRPC4 Gene
Compound | Action | Cas Number |
---|---|---|
HC-030031 | TRPA1 channel blocker,potent and selective | 349085-38-7 |
Optovin | 348575-88-2 | |
SKF 96365 hydrochloride | SOCE inhibitor | 130495-35-1 |
WS 3 | 39711-79-0 |
Transcripts for TRPC4 Gene
mRNA/cDNA for TRPC4 Gene
- (11) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (25) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TRPC4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TRPC4
- genomics-online: gRNA clones - Search results for 155 available TRPC4 gene related products
- Overview of 155 available TRPC4 gene related products
-
Recommended
- Applied Biological Materials CRISPR for TRPC4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRPC4
- GenScript: Design CRISPR guide RNA sequences for TRPC4
miRNA Products
- Search ViGene Biosciences for TRPC4
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TRPC4
- Browse OriGene Inhibitory RNA Products For TRPC4
- genomics-online: shRNA clones - Search results for 155 available TRPC4 gene related products
- Overview of 155 available TRPC4 gene related products
-
Recommended
Clone Products
-
OriGene ORF clones in human for TRPC4
- RC226709L1V
- RC226709L2V
- RC226715L1V
- RC226715L2V
- RC226722L1V
- RC226722L2V
- RC226733L1V
- RC226733L2V
- RC226703L1V
- RC226703L2V
- RC218941L1V
- RC218941L2V
- RC226709
- RC226709L1
- RC226709L2
- RG226709
- RC226715
- RC226715L1
- RC226715L2
- RG226715
- RC226722
- RC226722L1
- RC226722L2
- RG226722
- RC226733
- RC226733L1
- RC226733L2
- RG226733
- RC226703
- RC226703L1
- RC226703L2
- RG226703
- RC218941
- RC218941L1
- RC218941L2
- RG218941
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TRPC4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TRPC4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TRPC4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 155 available TRPC4 gene related products
- Overview of 155 available TRPC4 gene related products
-
Recommended
- orf clones - Search results for 155 available TRPC4 gene related products
- Overview of 155 available TRPC4 gene related products
-
Recommended
- Applied Biological Materials Clones for TRPC4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||
SP7: | - | - | |||||||||||||||||||||||||||||||
SP8: | - | - |
Expression for TRPC4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
- GABAergic Amacrine Cells Inner Nuclear Layer
- Skeletal Muscle (Muscoskeletal System)
- Inner Cell Mass (Early Embryonic Tissues)
- Blood (Hematopoietic System)
- Mesenchymal Stem Cells
- Umbilical Cord (Extraembryonic Tissues)
-
Epithelial Cells
- Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
-
Neurons
- GABAergic Amacrine Cells Inner Nuclear Layer
- Smooth Muscle (Muscoskeletal System)
- Lung (Respiratory System)
mRNA differential expression in normal tissues according to GTEx for TRPC4 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRPC4 Gene
NURSA nuclear receptor signaling pathways regulating expression of TRPC4 Gene:
TRPC4SOURCE GeneReport for Unigene cluster for TRPC4 Gene:
Hs.262960mRNA Expression by UniProt/SwissProt for TRPC4 Gene:
Q9UBN4-TRPC4_HUMANEvidence on tissue expression from TISSUES for TRPC4 Gene
- Kidney(4.3)
- Nervous system(2.5)
Primer Products
-
OriGene qPCR primer pairs for TRPC4
- genomics-online: primer clones - Search results for 155 available TRPC4 gene related products
- Overview of 155 available TRPC4 gene related products
-
Recommended
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRPC4 Gene
Orthologs for TRPC4 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | TRPC4 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | TRPC4 33 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | TRPC4 34 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | TRPC4 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Trpc4 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Trpc4 33 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | TRPC4 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | TRPC4 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | TRPC4 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | trpc4 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | trpc4b 34 |
|
OneToMany | |
TRPC4 (2 of 2) 34 |
|
OneToMany | |||
trpc4 33 |
|
||||
Dr.24084 33 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008435 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | trpgamma 35 33 34 |
|
||
trpl 35 34 |
|
||||
trp 35 34 |
|
||||
worm (Caenorhabditis elegans) |
Secernentea | trp-2 33 34 |
|
||
trp-1 35 |
|
|
|||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany |
- Species where no ortholog for TRPC4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for TRPC4 Gene
(6) SIMAP similar genes for TRPC4 Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for TRPC4 Gene
Variants for TRPC4 Gene
SNP ID | Clin | Chr 13 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs193920981 | uncertain-significance, Malignant tumor of prostate | 37,746,311(-) | G/A | 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, intron_variant, missense_variant | |
VAR_036452 | A breast cancer sample | p.Glu138Lys | |||
rs1000015292 | -- | 37,705,023(-) | A/G | genic_upstream_transcript_variant, intron_variant | |
rs1000015902 | -- | 37,723,361(-) | A/G | genic_upstream_transcript_variant, intron_variant | |
rs1000018976 | -- | 37,827,450(-) | G/T | genic_upstream_transcript_variant, intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv983e59 | CNV | insertion | 20981092 |
esv1262429 | CNV | insertion | 17803354 |
esv2661529 | CNV | deletion | 23128226 |
esv2668113 | CNV | deletion | 23128226 |
esv3302581 | CNV | tandem duplication | 20981092 |
esv3304452 | CNV | mobile element insertion | 20981092 |
esv33246 | CNV | gain | 17666407 |
esv34109 | CNV | loss | 18971310 |
esv3419690 | CNV | insertion | 20981092 |
esv3435362 | CNV | insertion | 20981092 |
esv3631804 | CNV | loss | 21293372 |
esv3631805 | CNV | loss | 21293372 |
esv3631806 | CNV | loss | 21293372 |
esv3631808 | CNV | loss | 21293372 |
esv3631809 | CNV | loss | 21293372 |
esv3631810 | CNV | loss | 21293372 |
nsv1113558 | CNV | deletion | 24896259 |
nsv1142828 | CNV | tandem duplication | 24896259 |
nsv471935 | CNV | novel sequence insertion | 20440878 |
nsv64068 | CNV | insertion | 16902084 |
nsv64072 | CNV | insertion | 16902084 |
nsv826617 | CNV | loss | 20364138 |
nsv983740 | CNV | duplication | 23825009 |
Additional Variant Information for TRPC4 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRPC4 Gene
Disorders for TRPC4 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
photosensitive epilepsy |
|
|
Additional Disease Information for TRPC4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for TRPC4 Gene
Publications for TRPC4 Gene
- Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction. (PMID: 19996314) Graziani A … Groschner K (The Journal of biological chemistry 2010) 3 4 22 58
- The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5. (PMID: 20164195) Miehe S … Strübing C (The Journal of biological chemistry 2010) 3 4 22 58
- Activation of the endothelial store-operated ISOC Ca2+ channel requires interaction of protein 4.1 with TRPC4. (PMID: 16254212) Cioffi DL … Stevens T (Circulation research 2005) 3 4 22 58
- Functional differences between TRPC4 splice variants. (PMID: 11713258) Schaefer M … Schultz G (The Journal of biological chemistry 2002) 3 4 22 58
- The PDZ-interacting domain of TRPC4 controls its localization and surface expression in HEK293 cells. (PMID: 12154080) Mery L … Hoth M (Journal of cell science 2002) 3 4 22 58
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Sources for TRPC4 Gene
- (1) GeneCards
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- (36) SGD
- (37) FlyBase
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- (39) Pseudogene
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- (41) dbSNP
- (42) GenAtlas
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- (46) HuGE
- (47) Atlas
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- (49) GenBank
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- (53) IMGT
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- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
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- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
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- (80) miRTarBase
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