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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TRPC4 Gene

protein-coding GIFtS: 66
GCID: GC13M038210

Transient Receptor Potential Cation Channel, Subfamily C,...

11 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Transient Receptor Potential Cation Channel, Subfamily C, Member 4¹ ²		Short Transient Receptor Potential Channel 4²
Trp-Related Protein 4² ³		TrpC4³
TRP4² ⁵		hTrp-4³
HTRP-4²		hTrp4³
HTRP4²

External Ids:	HGNC: 12336¹	Entrez Gene: 7223²	Ensembl: ENSG00000133107⁷	OMIM: 603651⁵	UniProtKB: Q9UBN4³

Export aliases for TRPC4 gene to outside databases

Previous GC identifers: GC13M036197 GC13M032197 GC13M037147 GC13M036008 GC13M037108 GC13M019010

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRPC4 Gene:

This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded

protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and

tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation,

neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated

with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple

isoforms have been observed for this gene. (provided by RefSeq, Aug 2011)

GeneCards Summary for TRPC4 Gene:

TRPC4 (transient receptor potential cation channel, subfamily C, member 4) is a protein-coding gene. Diseases associated with TRPC4 include endotheliitis, and anorexia nervosa, and among its related super-pathways are Axon guidance and CREB Pathway. GO annotations related to this gene include beta-catenin binding and store-operated calcium channel activity. An important paralog of this gene is TRPC1.

UniProtKB/Swiss-Prot: TRPC4_HUMAN, Q9UBN4

Function: Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell

contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger

system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an

enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion

summary for TRPC4 Gene:

The classical or canonical transient receptor potential (TRPC) channels are the subfamily most closely

related to the founding member of the TRP family, the Drosophila TRP channel. TRPC channels have seven TRPC

genes that encode the channel protein; these are named TRPC1-7 (TRPC2 is a pseudogene in humans). They are

non-selective, calcium permeable cation channels; however their permeability ratio of calcium/sodium ions

varies between different members of the family. Generally, TRPC channels can be activated by phospholipase

C, with some members (TRPC3, -6 and -7) being activated directly by diacylglycerol (DAG).

Gene Wiki entry for TRPC4 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000013.10 NC_018924.2 NT_024524.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TRPC4 gene promoter:
HOXA9B HOXA9 Egr-3 Egr-1 FOXD1 HSF1 (long) CREB deltaCREB Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRPC4 promoter sequence

Search SABiosciences Chromatin IP Primers for TRPC4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRPC4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q13.3 Ensembl cytogenetic band: 13q13.3 HGNC cytogenetic band: 13q13.3

TRPC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRPC4 gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13M038210: view genomic region (about GC identifiers)

Start:	38,210,773 bp from pter	End:	38,444,562 bp from pter
Size:	233,790 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRPC4_HUMAN, Q9UBN4 (See protein sequence)

Recommended Name: Short transient receptor potential channel 4

Size: 977 amino acids; 112101 Da

Subunit: Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC1 and/or TRPC5. Isoform

alpha but not isoform beta associates with inositol 1,4,5-trisphosphate receptor (ITPR). Interacts with (via

PDZ-binding domain) with SLC9A3R1/NHERF. Interacts with MX1 and RNF24. Interacts (via CIRB domain) with SESTD1

(via spectrin 1 repeat). Interacts with CDH5 and CTNNB1. Interacts with SPTAN1 (via C-terminal spectrin repeats)

and SPTBN5 (via C-terminus). Interacts (via protein 4.1-binding domain) with EPB41L2

Subcellular location: Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Note=Enhanced insertion into the cell membrane after activation of the EGF receptor

Miscellaneous: The interaction with spectrin is important in controlling the translocation of TRPC4 channels to

the plasma membrane following EGF stimulation

Miscellaneous: The cell membrane presentation, the calcium entry function and the interaction with junctional

proteins (CTNNB1 and CDH5) are controlled by endothelial cell-cell contacts

Secondary accessions: B1ALE0 B1ALE1 B1ALE2 Q15721 Q3SWS6 Q96P03 Q96P05 Q9UIB0 Q9UIB1 Q9UIB2

Alternative splicing: 6 isoforms: Q9UBN4-1 Q9UBN4-2 Q9UBN4-3 Q9UBN4-4 Q9UBN4-5 Q9UBN4-6

Explore the universe of human proteins at neXtProt for TRPC4: NX_Q9UBN4

Explore proteomics data for TRPC4 at MOPED

Post-translational modifications:

UniProtKB: Phosphorylation modulates TRPC channel function by regulating the level of TRPC4 at the cell surface and by

increasing the association with SLC9A3R1/NHERF

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9UBN4

TRPC4 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (6 alternative transcripts):

NP_001129427.1 NP_001129428.1 NP_001129429.1 NP_001129430.1 NP_003297.1 NP_057263.1

ENSEMBL proteins:

ENSP00000369027 ENSP00000369001 ENSP00000435969 ENSP00000348025 ENSP00000351264

ENSP00000368995 ENSP00000369003 ENSP00000342580 ENSP00000414316 ENSP00000410133

Reactome Protein details: Q9UBN4
Human Recombinant Protein Products for TRPC4:

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	Cloud-Clone Corp. Proteins for TRPC4

Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IDA	16254212
GO:0005901	caveola	IEA	--
GO:0005911	colocalizes with cell-cell junction	IDA	19996314
GO:0009986	cell surface	IDA	19996314
GO:0016020	membrane	--	--

TRPC4 for ontologies About GeneDecksing

TRPC4 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of TRPC4
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	Novus Biologicals TRPC4 Antibodies
	Abcam antibodies for TRPC4
	Cloud-Clone Corp. Antibodies for TRPC4
	ThermoFisher Antibodies for TRPC4
	LSBio Antibodies in human, mouse, rat for TRPC4

Assay Products for TRPC4:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for TRPC4
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TRPC4
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for TRPC4 Cloud-Clone Corp. CLIAs for TRPC4

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

TRP: Voltage-gated ion channels / Transient receptor potential cation channels

ANKRD: Ankyrin repeat domain containing

IUPHAR Guide to PHARMACOLOGY protein family classification: TRPC4

Transient Receptor Potential channels

5/7 InterPro protein domains (see all 7):

IPR005460 TRPC4_channel

IPR002153 TRPC_channel

IPR020683 Ankyrin_rpt-contain_dom

IPR005821 Ion_trans_dom

IPR004729 TRP_channel

Graphical View of Domain Structure for InterPro Entry Q9UBN4

ProtoNet protein and cluster: Q9UBN4

4 Blocks protein domains:

IPB002110 Ankyrin repeat signature

IPB002153 Transient receptor potential family signature

IPB005460 Transient receptor potential channel 4 signature

IPB013555 Transient receptor ion channel II

UniProtKB/Swiss-Prot: TRPC4_HUMAN, Q9UBN4

Domain: The protein 4.1-binding domain (654-685) is required for binding to EPB41L2 and channel activation

Domain: The calmodulin- and inositol 1,4,5-trisphosphate receptor-binding (CIRB) domain (695-724) is sufficient

for the interaction with SESTD1

Domain: The spectrin-binding domain (730-758) is required for binding to SPTAN1 and SPTBN5

Similarity: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily

Similarity: Contains 4 ANK repeats

TRPC4 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TRPC4_HUMAN, Q9UBN4

Function: Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell

contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger

system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an

enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005216	ion channel activity	--	--
GO:0005262	calcium channel activity	--	--
GO:0005515	protein binding	IPI	15757897
GO:0008013	beta-catenin binding	IPI	19996314
GO:0015279	store-operated calcium channel activity	IMP	16254212

TRPC4 for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for TRPC4:

Low eccentricity cells

Synthetic lethal with c-Myc af

Synthetic lethal with cisplati

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Trpc4):

cardiovascular system

muscle

nervous system

normal

TRPC4 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Trpc4^tm1Bni for TRPC4

inGenious Targeting Laboratory - Custom generated mouse model solutions for TRPC4

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRPC4

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRPC4

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRPC4

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRPC4
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate TRPC4:
		hsa-miR-187* hsa-miR-300 hsa-miR-1283 hsa-miR-101 hsa-miR-381
		SwitchGear 3'UTR luciferase reporter plasmid: TRPC4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for TRPC4
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 6): TRPC4 (NM_016179)
		Sino Biological Human cDNA Clone for TRPC4
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TRPC4
		Search LifeMap BioReagents cell lines for TRPC4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC4

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for TRPC4 About (see all 6)

See pathways by source

SuperPath

Contained pathways About

Axon guidance

Axon guidance

0.69

Developmental Biology

0.69

CREB Pathway

Intracellular Calcium Signaling

0.50

Netrin-1 signaling

Netrin-1 signaling

0.33

Sodium channels and transporters: inward current

Sodium channels and transporters: inward current

Role of second messengers in netrin-1 signaling

Role of second messengers in netrin-1 signaling

Pathways by source See SuperPaths
Show all pathways

2 EMD Millipore Pathways for TRPC4

	Sodium channels and transporters- inward current
	Calcium channels

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TRPC4

Intracellular Calcium Signaling

4 Reactome Pathways for TRPC4

	Developmental Biology
	Netrin-1 signaling
	Role of second messengers in netrin-1 signaling
	Axon guidance

TRPC4 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TRPC4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/49 Interacting proteins for TRPC4 (Q9UBN4^{1, 2, 3} ENSP00000369003⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 49)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ITPR2	Q14571²^,³, ENSP00000370744⁴	MINT-14530 MINT-14529 I2D: score=3 STRING: ENSP00000370744
MX1	P20591¹^,³, ENSP00000381599⁴	EBI-929504,EBI-929476 I2D: score=3 STRING: ENSP00000381599
ITPR3	Q14573³, ENSP00000363435⁴	I2D: score=2 STRING: ENSP00000363435
SLC9A3R1	O14745³, ENSP00000262613⁴	I2D: score=2 STRING: ENSP00000262613
TRPC5	Q9UL62³, ENSP00000262839⁴	I2D: score=2 STRING: ENSP00000262839

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	--	--
GO:0006816	calcium ion transport	TAS	8646775
GO:0007411	axon guidance	TAS	--
GO:0014051	gamma-aminobutyric acid secretion	IEA	--
GO:0055085	transmembrane transport	--	--

TRPC4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TRPC4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for TRPC4 available from Tocris Bioscience About this table

Compound	Action	CAS #
Pyr3	Selective TRPC3 channel blocker	[1160514-60-2]
GsMTx4	TRPC1 and TRPC6 blocker; inhibits mechanosensitive ion channels	--
ML 204	Selective TRPC4 blocker	[5465-86-1]

1 HMDB Compound for TRPC4 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

5 IUPHAR Ligands for TRPC4 (TRPC4) About this table

Ligand	Type	Action	Affinity	Pubmed IDs
ML204	Channel blocker	None	5.5	21795696
SKF96365	Channel blocker	None	5.5	--
La³⁺	Channel blocker	None	5.5	--
2-APB	Channel blocker	None	5.5	--
niflumic acid	Channel blocker	None	5.5	--

9 Novoseek inferred chemical compound relationships for TRPC4 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
1-oleoyl-2-acetyl-sn-glycerol	71.8	1	12721302 (1)
thapsigargin	70.8	3	12736151 (1), 11830588 (1), 19523685 (1)
calcium	58.4	31	16254212 (2), 15229105 (2), 15546997 (2), 19523685 (2) (see all 17)
inositol 1,4,5 trisphosphate	45	2	15654973 (1), 20164195 (1)
carbachol	37.4	5	11830588 (4)
atp	0	11	15229105 (3)
nitric oxide	0	2	16998480 (1)
lipid	0	3	16270640 (1), 20164195 (1)
tyrosine	0	1	15902430 (1)

Search CenterWatch for drugs/clinical trials and news about TRPC4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TRPC4 gene (6 alternative transcripts):

NM_001135955.1 NM_001135956.1 NM_001135957.1 NM_001135958.1 NM_003306.1 NM_016179.2

Unigene Cluster for TRPC4:

Transient receptor potential cation channel, subfamily C, member 4

Hs.262960 [show with all ESTs]

Unigene Representative Sequence: BX648312

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000379705(uc010abv.3 uc001uwt.3 uc001uws.3 uc010tey.2 uc010abw.3 uc010aby.3)

ENST00000379679 ENST00000488717 ENST00000355779 ENST00000358477 ENST00000379673

ENST00000494529 ENST00000379681(uc010abx.3) ENST00000338947 ENST00000447043

ENST00000426868

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Additional mRNA sequence:

AF063822.1 AF063823.1 AF063824.1 AF063825.1 AF175406.1 AF421358.1 AF421359.1 AF421360.1

AF421362.1 AK312524.1 BC104725.1 BC105641.1 BC105917.1 BX648312.1 U40983.1

4 DOTS entries:

DT.40260695 DT.92419684 DT.92419686 DT.40303044

24/25 AceView cDNA sequences (see all 25):

AF421359 NM_016179 AF175406 AF421362 AF421358 U40983 AF421361 BP378220

BX092795 AF421360 BX648312 AI383963 BP376494 BP376399 AF063824 AF063823

BP378906 AF063822 AF063825 AI082121 AA629948 C02173 BG189786 BG205685

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TRPC4 (see all 8) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10a	·	10b	^	11	^	12a	·	12b
SP1:																					-
SP2:																					-						-		-
SP3:																					-
SP4:																			-		-
SP5:															-						-

ECgene alternative splicing isoforms for TRPC4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRPC4 expression in normal human tissues (normalized intensities) TRPC4 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTTAAATAAG

About this image

TRPC4 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/7 selected tissues (see all 7) fully expand


Blood (Hematopoietic System) fully expand to see all 2 entries
Umbilical cord blood-derived mesenchymal stem cells
cd49a+ cells

Skeletal Muscle (Muscoskeletal System) fully expand to see all 2 entries
Myoblasts Mandibular Arch Muscles

Eye (Sensory Organs) fully expand to see all 2 entries
Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium

Umbilical Cord (Extraembryonic Tissues)
Umbilical cord blood-derived mesenchymal stem cells

Inner Cell Mass (Early Embryonic Tissues)
Line H7 (WA07)

See TRPC4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRPC4

SOURCE GeneReport for Unigene cluster: Hs.262960

UniProtKB/Swiss-Prot: TRPC4_HUMAN, Q9UBN4

Tissue specificity: Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and

brain. Expressed in endothelial cells. Isoform alpha was found to be the predominant isoform. Isoform beta was

not found in pancreas and brain

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TRPC4 gene from 6/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Trpc4^{1 , 5}	transient receptor potential cation channel, subfamily more^{1, 5}	88.25(n)¹ 97.33(a)¹		3 (25.43 cM)⁵ 22066¹ NM_016984.3¹ NP_058680.1¹ 54156057⁵
chicken (Gallus gallus)	Aves	TRPC4¹	transient receptor potential cation channel, subfamily more	79.12(n) 85.32(a)		418895 XM_417089.3 XP_417089.2
lizard (Anolis carolinensis)	Reptilia	TRPC4⁶	Uncharacterized protein	83(a)	1 ↔ 1	2(82170608-82275900)
zebrafish (Danio rerio)	Actinopterygii	Dr.24084²	Danio rerio cDNA clone IMAGE2643303	74.53(n)		BC058321.1
fruit fly (Drosophila melanogaster)	Insecta	trp&ggr;³ trpgamma¹	calcium ion transport calcium channel³ CG5996-PA¹	52(a) (best of 3)³ 56.12(n)¹ 55.8(a)¹		36A9³ 34991¹ NM_135958.3¹ NP_609802.1¹
worm (Caenorhabditis elegans)	Secernentea	trp-1³ trp-2¹	Transient-receptor-potential (trp) protein³ Protein TRP-2¹	41(a)³ 52.59(n)¹ 48.5(a)¹		III(8607645-8614376)³ 192056¹ NM_001027532.2¹ NP_001022703.1¹

ENSEMBL Gene Tree for TRPC4 (if available)
TreeFam Gene Tree for TRPC4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for TRPC4 gene

TRPC1² TRPC7² TRPC6² TRPC5² TRPC3²

6 SIMAP similar genes for TRPC4 using alignment to 5 protein entries: TRPC4_HUMAN (see all proteins):

TRPC5 TRPC1 TRP7 TRPC7 TRPC6 TRPC3

TRPC4 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for TRPC4
PGOHUM00000250394

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_036452⁴		A breast cancer sample⁴	--	see VAR_036452	2	E K	mis⁴		0	--	--	--	--
rs116527482^1,2	C	untested¹	19157983(+)	`TCTTCG/AGTCAG`	11	/T	syn¹ int¹		2		EA NA	4754
rs150319236^1,2	C	--	19016356(+)	`CTTTC-/TTTTTT`	6	--	int¹		0	--	--	--	--
rs11345629^1,2	C	--	19022633(+)	`AGGTAT/-TTTTT`	6	--	int¹ trp³		1		CSA	2
rs143560719^1,2	C	--	19039634(+)	`CCAGG-/AAAAAA`	6	--	int¹		0	--	--	--	--
rs11389220^1,2	C	--	19064491(+)	`TTTTT-/TCTGCC`	6	--	int¹ trp³		0	--	--	--	--
rs367605701^1,2	C	--	19066758(+)	`GTTAA-/AGGGGTTA`	6	--	cds¹		0	--	--	--	--
rs74217427^1,2	F	--	19069808(-)	`GTCTGC/TCACCA`	6	--	int¹		3		NA	6
rs77006960^1,2	C	--	19069831(-)	`CCCTGG/AAAATG`	6	--	int¹		1		NA	2
rs76358820^1,2	C	--	19069849(+)	`CTTTAC/TAAAAC`	6	--	int¹		1		NA	2

HapMap Linkage Disequilibrium report for TRPC4 (38210773 - 38444562 bp)

Structural Variations
Database of Genomic Variants (DGV) 10/11 variations for TRPC4 (see all 11): About this table

Variant ID	Type	Subtype	PubMed ID
esv2668113	CNV	Deletion	23128226
esv2661529	CNV	Deletion	23128226
nsv64068	CNV	Insertion	16902084
esv1262429	CNV	Insertion	17803354
nsv64072	CNV	Insertion	16902084
esv268730	CNV	Insertion	20981092
esv34109	CNV	Loss	18971310
nsv899995	CNV	Loss	21882294
nsv826617	CNV	Loss	20364138
esv33246	CNV	Gain	17666407

Human Gene Mutation Database (HGMD): TRPC4

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 603651 OMIM disorders: --

11 diseases for TRPC4: About MalaCards

endotheliitis anorexia nervosa basal cell carcinoma gingivitis

hypertension myocardial infarction renal cell carcinoma hypoxia

prostate cancer prostatitis neuronitis

TRPC4 for disorders About GeneDecksing

Genetic Association Database (GAD): TRPC4
Human Genome Epidemiology (HuGE) Navigator: TRPC4 (3 documents)

Export disorders for TRPC4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TRPC4 gene, integrated from 9 sources (see all 102):
(articles sorted by number of sources associating them with TRPC4)

Utopia: connect your pdf to the dynamic
world of online information

trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. (PubMed id 8646775)^{1, 2, 3} Zhu X....Birnbaumer L. (1996)
Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction. (PubMed id 19996314)^{1, 2, 9} Graziani A.... Groschner K. (2010)
Cloning and expression of the human transient receptor potential 4 (TRP4) gene: localization and functional expression of human TRP4 and TRP3. (PubMed id 11042129)^{1, 2, 9} McKay R.R.... Putney J.W. Jr. (2000)
The PDZ-interacting domain of TRPC4 controls its localization and surface expression in HEK293 cells. (PubMed id 12154080)^{1, 2, 9} Mery L....Hoth M. (2002)
Activation of the endothelial store-operated ISOC Ca2+ channel requires interaction of protein 4.1 with TRPC4. (PubMed id 16254212)^{1, 2, 9} Cioffi D.L.... Stevens T. (2005)
The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5. (PubMed id 20164195)^{1, 2, 9} Miehe S....Strubing C. (2010)
Functional differences between TRPC4 splice variants. (PubMed id 11713258)^{1, 2, 9} Schaefer M.... Schultz G. (2002)
Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)^{1, 4} Pinheiro A.P....Woodside D.B. (2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (2010)
Association study of TRPC4 as a candidate gene for ge neralized epilepsy with photosensitivity. (PubMed id 20574736)^{1, 4} von Spiczak S....Stephani U. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7223	HGNC: 12336	AceView: TRPC4	Ensembl:ENSG00000133107	euGenes: HUgn7223
ECgene: TRPC4	H-InvDB: TRPC4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TRPC4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TRPC4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TRPC4 gene:
Search GeneIP for patents involving TRPC4

GeneCards and IP:
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