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Set Analyses:

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TRPC4 Gene

protein-coding GIFtS: 66
GCID: GC13M038210

Transient Receptor Potential Cation Channel, Subfamily C,...

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Transient Receptor Potential Cation Channel, Subfamily C, Member 4¹ ²		Short Transient Receptor Potential Channel 4²
Trp-Related Protein 4² ³		TrpC4³
TRP4² ⁵		hTrp-4³
HTRP-4²		hTrp4³
HTRP4²

External Ids:	HGNC: 12336¹	Entrez Gene: 7223²	Ensembl: ENSG00000133107⁷	OMIM: 603651⁵	UniProtKB: Q9UBN4³

Export aliases for TRPC4 gene to outside databases

Previous GC identifers: GC13M036197 GC13M032197 GC13M037147 GC13M036008 GC13M037108 GC13M019010

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRPC4 Gene:

This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded

protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and

tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation,

neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated

with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple

isoforms have been observed for this gene. (provided by RefSeq, Aug 2011)

GeneCards Summary for TRPC4 Gene:

TRPC4 (transient receptor potential cation channel, subfamily C, member 4) is a protein-coding gene. Diseases associated with TRPC4 include endotheliitis, and anorexia nervosa. GO annotations related to this gene include beta-catenin binding and store-operated calcium channel activity. An important paralog of this gene is TRPC1.

UniProtKB/Swiss-Prot: TRPC4_HUMAN, Q9UBN4

Function: Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell

contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger

system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an

enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion

summary for TRPC4 Gene:

The classical or canonical transient receptor potential (TRPC) channels are the subfamily most closely

related to the founding member of the TRP family, the Drosophila TRP channel. TRPC channels have seven TRPC

genes that encode the channel protein; these are named TRPC1-7 (TRPC2 is a pseudogene in humans). They are

non-selective, calcium permeable cation channels; however their permeability ratio of calcium/sodium ions

varies between different members of the family. Generally, TRPC channels can be activated by phospholipase

C, with some members (TRPC3, -6 and -7) being activated directly by diacylglycerol (DAG).

Gene Wiki entry for TRPC4 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000013.11 NC_018924.2 NT_024524.15

Regulatory elements:

Regulatory transcription factor binding sites in the TRPC4 gene promoter:
HOXA9B HOXA9 Egr-3 Egr-1 FOXD1 HSF1 (long) CREB deltaCREB Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRPC4 promoter sequence

Search Chromatin IP Primers for TRPC4

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRPC4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q13.3 Ensembl cytogenetic band: 13q13.3 HGNC cytogenetic band: 13q13.3

TRPC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRPC4 gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13M038210: view genomic region (about GC identifiers)

Start:	38,210,773 bp from pter	End:	38,444,562 bp from pter
Size:	233,790 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TRPC4_HUMAN, Q9UBN4 (See protein sequence)

Recommended Name: Short transient receptor potential channel 4

Size: 977 amino acids; 112101 Da

Subunit: Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC1 and/or TRPC5. Isoform

alpha but not isoform beta associates with inositol 1,4,5-trisphosphate receptor (ITPR). Interacts with (via

PDZ-binding domain) with SLC9A3R1/NHERF. Interacts with MX1 and RNF24. Interacts (via CIRB domain) with SESTD1

(via spectrin 1 repeat). Interacts with CDH5 and CTNNB1. Interacts with SPTAN1 (via C-terminal spectrin repeats)

and SPTBN5 (via C-terminus). Interacts (via protein 4.1-binding domain) with EPB41L2

Miscellaneous: The interaction with spectrin is important in controlling the translocation of TRPC4 channels to

the plasma membrane following EGF stimulation

Miscellaneous: The cell membrane presentation, the calcium entry function and the interaction with junctional

proteins (CTNNB1 and CDH5) are controlled by endothelial cell-cell contacts

Secondary accessions: B1ALE0 B1ALE1 B1ALE2 Q15721 Q3SWS6 Q96P03 Q96P04 Q96P05 Q9UIB0 Q9UIB1

Q9UIB2

Alternative splicing: 7 isoforms: Q9UBN4-1 Q9UBN4-2 Q9UBN4-3 Q9UBN4-4 Q9UBN4-5 Q9UBN4-6 Q9UBN4-7

Explore the universe of human proteins at neXtProt for TRPC4: NX_Q9UBN4

Explore proteomics data for TRPC4 at MOPED

Post-translational modifications:

Phosphorylation modulates TRPC channel function by regulating the level of TRPC4 at the cell surface and by

increasing the association with SLC9A3R1/NHERF¹

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See TRPC4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (6 alternative transcripts):

NP_001129427.1 NP_001129428.1 NP_001129429.1 NP_001129430.1 NP_003297.1 NP_057263.1

ENSEMBL proteins:

ENSP00000369027 ENSP00000369001 ENSP00000435969 ENSP00000348025 ENSP00000351264

ENSP00000368995 ENSP00000369003 ENSP00000342580 ENSP00000414316 ENSP00000410133

Reactome Protein details: Q9UBN4

TRPC4 Human Recombinant Protein Products:

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TRPC4 Assay Products:

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	Cloud-Clone Corp. ELISAs for TRPC4 Cloud-Clone Corp. CLIAs for TRPC4

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

TRP: Voltage-gated ion channels / Transient receptor potential cation channels

ANKRD: Ankyrin repeat domain containing

IUPHAR Guide to PHARMACOLOGY protein family classification: TRPC4

Transient Receptor Potential channels

Selected InterPro protein domains (see all 7):

IPR005460 TRPC4_channel

IPR002153 TRPC_channel

IPR005821 Ion_trans_dom

IPR004729 TRP_channel

IPR002110 Ankyrin_rpt

Graphical View of Domain Structure for InterPro Entry Q9UBN4

ProtoNet protein and cluster: Q9UBN4

4 Blocks protein domains:

IPB002110 Ankyrin repeat signature

IPB002153 Transient receptor potential family signature

IPB005460 Transient receptor potential channel 4 signature

IPB013555 Transient receptor ion channel II

UniProtKB/Swiss-Prot: TRPC4_HUMAN, Q9UBN4

Domain: The protein 4.1-binding domain (654-685) is required for binding to EPB41L2 and channel activation

Domain: The calmodulin- and inositol 1,4,5-trisphosphate receptor-binding (CIRB) domain (695-724) is sufficient

for the interaction with SESTD1

Domain: The spectrin-binding domain (730-758) is required for binding to SPTAN1 and SPTBN5

Similarity: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily

Similarity: Contains 4 ANK repeats

TRPC4 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: TRPC4_HUMAN, Q9UBN4

Function: Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell

contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger

system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an

enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion

Gene Ontology (GO): Selected molecular function terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005216	ion channel activity	--	--
GO:0005262	calcium channel activity	--	--
GO:0005515	protein binding	IPI	15757897
GO:0008013	beta-catenin binding	IPI	19996314
GO:0015279	store-operated calcium channel activity	IMP	16254212

TRPC4 for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for TRPC4:

Low eccentricity cells

Synthetic lethal with c-Myc af

Synthetic lethal with cisplati

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Trpc4):

cardiovascular system

muscle

nervous system

normal

TRPC4 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Trpc4^tm1Bni for TRPC4

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRPC4

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRPC4

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRPC4

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		hsa-miR-187* hsa-miR-300 hsa-miR-1283 hsa-miR-101 hsa-miR-381
		SwitchGear 3'UTR luciferase reporter plasmid: TRPC4 3' UTR sequence

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		Predesigned siRNA for gene silencing in human, mouse, rat TRPC4

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		GenScript: all cDNA clones in your preferred vector (see all 6): TRPC4 (NM_016179)
		Sino Biological Human cDNA Clone for TRPC4
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRPC4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPC4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TRPC4
		Browse ESI BIO Cell Lines and PureStem Progenitors for TRPC4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC4

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

TRPC4_HUMAN, Q9UBN4: Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Note=Enhanced insertion into the cell membrane after activation of the EGF receptor

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytoskeleton	5
plasma membrane	5
endoplasmic reticulum	2
cytosol	1
extracellular	1
peroxisome	1

About this image

Gene Ontology (GO): Selected cellular component terms (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005901	caveola	IEA	--
GO:0005911	colocalizes with cell-cell junction	IDA	19996314
GO:0009986	cell surface	IDA	19996314
GO:0016020	membrane	--	--

TRPC4 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for TRPC4 About (see all 8)

See pathways by source

SuperPath

Contained pathways About

L1CAM interactions

Axon guidance

0.63

Developmental Biology

0.63

Ion channel transport

Ion channel transport

0.58

Stimuli-sensing channels

0.58

Netrin-1 signaling

Netrin-1 signaling

Role of second messengers in netrin-1 signaling

0.00

CREB Pathway

Intracellular Calcium Signaling

0.50

Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds

Transmembrane transport of small molecules

0.47

Pathways by source See SuperPaths
Show all pathways

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TRPC4

Intracellular Calcium Signaling

2 Reactome Pathways for TRPC4

	TRP channels
	Role of second messengers in netrin-1 signaling

TRPC4 for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for TRPC4
Interactions:

GeneGlobe Interaction Network for TRPC4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for TRPC4 (Q9UBN4^{1, 2, 3} ENSP00000369003⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 57)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ITPR2	Q14571²^,³, ENSP00000370744⁴	MINT-14530 MINT-14529 I2D: score=3 STRING: ENSP00000370744
MX1	P20591¹^,³, ENSP00000381599⁴	EBI-929504,EBI-929476 I2D: score=3 STRING: ENSP00000381599
ITPR3	Q14573³, ENSP00000363435⁴	I2D: score=2 STRING: ENSP00000363435
SLC9A3R1	O14745³, ENSP00000262613⁴	I2D: score=2 STRING: ENSP00000262613
TRPC5	Q9UL62³, ENSP00000262839⁴	I2D: score=2 STRING: ENSP00000262839

About this table

Gene Ontology (GO): Selected biological process terms (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	--	--
GO:0006816	calcium ion transport	TAS	8646775
GO:0007411	axon guidance	TAS	--
GO:0014051	gamma-aminobutyric acid secretion	IEA	--
GO:0034220	ion transmembrane transport	TAS	--

TRPC4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Compounds for TRPC4 available from Tocris Bioscience About this table

Compound	Action	CAS #
Pyr3	Selective TRPC3 channel blocker	[1160514-60-2]
GsMTx4	TRPC1 and TRPC6 blocker; inhibits mechanosensitive ion channels	--
ML 204	Selective TRPC4 blocker	[5465-86-1]

1 HMDB Compound for TRPC4 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

5 IUPHAR Ligands for TRPC4 (TRPC4) About this table

Ligand	Type	Action	Affinity	Pubmed IDs
ML204	Channel blocker	None	5.5	21795696
SKF96365	Channel blocker	None	5.5	--
La³⁺	Channel blocker	None	5.5	--
2-APB	Channel blocker	None	5.5	--
niflumic acid	Channel blocker	None	5.5	--

9 Novoseek inferred chemical compound relationships for TRPC4 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
1-oleoyl-2-acetyl-sn-glycerol	71.8	1	12721302 (1)
thapsigargin	70.8	3	12736151 (1), 11830588 (1), 19523685 (1)
calcium	58.4	31	16254212 (2), 15229105 (2), 15546997 (2), 19523685 (2) (see all 17)
inositol 1,4,5 trisphosphate	45	2	15654973 (1), 20164195 (1)
carbachol	37.4	5	11830588 (4)
atp	0	11	15229105 (3)
nitric oxide	0	2	16998480 (1)
lipid	0	3	16270640 (1), 20164195 (1)
tyrosine	0	1	15902430 (1)

TRPC4 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for TRPC4 gene (6 alternative transcripts):

NM_001135955.1 NM_001135956.1 NM_001135957.1 NM_001135958.1 NM_003306.1 NM_016179.2

Unigene Cluster for TRPC4:

Transient receptor potential cation channel, subfamily C, member 4

Hs.262960 [show with all ESTs]

Unigene Representative Sequence: BX648312

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000379705(uc010abv.3 uc001uwt.3 uc001uws.3 uc010tey.2 uc010abw.3 uc010aby.3)

ENST00000379679 ENST00000488717 ENST00000355779 ENST00000358477 ENST00000379673

ENST00000494529 ENST00000379681(uc010abx.3) ENST00000338947 ENST00000447043

ENST00000426868

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		hsa-miR-187* hsa-miR-300 hsa-miR-1283 hsa-miR-101 hsa-miR-381
		SwitchGear 3'UTR luciferase reporter plasmid: TRPC4 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector (see all 6): TRPC4 (NM_016179)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRPC4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPC4

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for TRPC4
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat TRPC4
		QuantiTect SYBR Green Assays in human, mouse, rat TRPC4
		QuantiFast Probe-based Assays in human, mouse, rat TRPC4

Additional mRNA sequence:

AF063822.1 AF063823.1 AF063824.1 AF063825.1 AF175406.1 AF421358.1 AF421359.1 AF421360.1

AF421362.1 AK312524.1 BC104725.1 BC105641.1 BC105917.1 BX648312.1 U40983.1

4 DOTS entries:

DT.40260695 DT.92419684 DT.92419686 DT.40303044

Selected AceView cDNA sequences (see all 25):

AF421362 AF421358 BP378220 BX092795 NM_016179 AF175406 AF421359 AF421361

U40983 AF421360 BX648312 AI383963 BP376494 BP376399 AF063825 AF063822

BP378906 AF063824 AF063823 C02173 AA629948 AI082121 BG189786 BG205685

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for TRPC4 (see all 8) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10a	·	10b	^	11	^	12a	·	12b
SP1:																					-
SP2:																					-						-		-
SP3:																					-
SP4:																			-		-
SP5:															-						-

ECgene alternative splicing isoforms for TRPC4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TRPC4 expression in normal human tissues (normalized intensities) TRPC4 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTTAAATAAG

About this image

TRPC4 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 7) fully expand


Umbilical Cord (Extraembryonic Tissues) fully expand to see all 2 entries
Umbilical cord-derived mesenchymal stem cells (family)

Mesenchymal Stem Cells (Uncategorized) fully expand to see all 2 entries
Umbilical cord-derived mesenchymal stem cells (family)

Eye (Sensory Organs) fully expand to see all 2 entries
Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium

Skeletal Muscle (Muscoskeletal System) fully expand to see all 2 entries
Myoblasts Mandibular Arch Muscles

Epithelial Cells
Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium

TRPC4 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

TRPC4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.262960

UniProtKB/Swiss-Prot: TRPC4_HUMAN, Q9UBN4

Tissue specificity: Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and

brain. Expressed in endothelial cells. Isoform alpha was found to be the predominant isoform. Isoform beta was

not found in pancreas and brain

Custom PCR Arrays for TRPC4

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		QuantiFast Probe-based Assays in human, mouse, rat TRPC4

In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for TRPC4 gene from Selected species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Trpc4^{1 , 5}	transient receptor potential cation channel, subfamily more^{1, 5}	88.25(n)¹ 97.33(a)¹		3 (25.43 cM)⁵ 22066¹ NM_016984.3¹ NP_058680.1¹ 54156057⁵
chicken (Gallus gallus)	Aves	TRPC4¹	transient receptor potential cation channel, subfamily more	79.12(n) 85.32(a)		418895 XM_417089.4 XP_417089.2
lizard (Anolis carolinensis)	Reptilia	TRPC4⁶	transient receptor potential cation channel, subfa...	83(a)	1 ↔ 1	2(82170608-82275900)
tropical clawed frog (Xenopus tropicalis)	Amphibia	trpc4¹	transient receptor potential cation channel, subfamily more	74.99(n) 84.31(a)		100485338 XM_002939583.2 XP_002939629.2
zebrafish (Danio rerio)	Actinopterygii	Dr.24084²	Danio rerio cDNA clone IMAGE2643303	74.53(n)		BC058321.1
fruit fly (Drosophila melanogaster)	Insecta	trpgamma^{1 , 3}	calcium ion transport calcium channel³ trpgamma¹	52(a) (best of 3)³ 55.71(n)¹ 55.66(a)¹		36A9³ 34991¹ NM_135958.4¹ NP_609802.1¹
worm (Caenorhabditis elegans)	Secernentea	trp-1³ trp-2¹	Transient-receptor-potential (trp) protein³ trp-2¹	41(a)³ 52.37(n)¹ 48.24(a)¹		III(8607645-8614376)³ 192056¹ NM_001027532.3¹ NP_001022703.1¹

ENSEMBL Gene Tree for TRPC4 (if available)
TreeFam Gene Tree for TRPC4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for TRPC4 gene

TRPC1² TRPC7² TRPC6² TRPC5² TRPC3²

6 SIMAP similar genes for TRPC4 using alignment to 4 protein entries: TRPC4_HUMAN (see all proteins):

TRPC5 TRPC1 TRP7 TRPC6 TRPC7 TRPC3

TRPC4 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for TRPC4
PGOHUM00000250394

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_036452⁴		A breast cancer sample⁴	--	see VAR_036452	2	E K	mis⁴		0	--	--	--	--
rs116527482^1,2	C	untested¹	19157983(+)	`TCTTCG/AGTCAG`	11	/T	syn¹ int¹		2		EA NA	4754
rs150319236^1,2	C	--	19016356(+)	`CTTTC-/TTTTTT`	6	--	int¹		0	--	--	--	--
rs11345629^1,2	C	--	19022633(+)	`AGGTAT/-TTTTT`	6	--	int¹ trp³		1		CSA	2
rs143560719^1,2	C	--	19039634(+)	`CCAGG-/AAAAAA`	6	--	int¹		0	--	--	--	--
rs11389220^1,2	C	--	19064491(+)	`TTTTT-/TCTGCC`	6	--	int¹ trp³		0	--	--	--	--
rs367605701^1,2	C	--	19066758(+)	`GTTAA-/AGGGGTTA`	6	--	cds¹		0	--	--	--	--
rs74217427^1,2	F	--	19069808(-)	`GTCTGC/TCACCA`	6	--	int¹		3		NA	6
rs77006960^1,2	C	--	19069831(-)	`CCCTGG/AAAATG`	6	--	int¹		1		NA	2
rs76358820^1,2	C	--	19069849(+)	`CTTTAC/TAAAAC`	6	--	int¹		1		NA	2

HapMap Linkage Disequilibrium report for TRPC4 (38210773 - 38444562 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for TRPC4 (see all 11): About this table

Variant ID	Type	Subtype	PubMed ID
esv2668113	CNV	Deletion	23128226
esv2661529	CNV	Deletion	23128226
nsv64068	CNV	Insertion	16902084
esv1262429	CNV	Insertion	17803354
nsv64072	CNV	Insertion	16902084
esv268730	CNV	Insertion	20981092
esv34109	CNV	Loss	18971310
nsv899995	CNV	Loss	21882294
nsv826617	CNV	Loss	20364138
esv33246	CNV	Gain	17666407

Human Gene Mutation Database (HGMD): TRPC4

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 603651 OMIM disorders: --

17 diseases for TRPC4: About MalaCards

endotheliitis anorexia nervosa basal cell carcinoma age related macular degeneration

gingivitis myocardial infarction breast and colorectal cancer renal cell carcinoma

hypertension hypoxia obesity retinitis

prostate cancer prostatitis colorectal cancer neuronitis

malaria

TRPC4 for disorders About GeneDecksing

Genetic Association Database (GAD): TRPC4
Human Genome Epidemiology (HuGE) Navigator: TRPC4 (3 documents)

Export disorders for TRPC4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TRPC4 gene, integrated from 10 sources (see all 104):
(articles sorted by number of sources associating them with TRPC4)

Utopia: connect your pdf to the dynamic
world of online information

trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. (PubMed id 8646775)^{1, 2, 3} Zhu X....Birnbaumer L. (Cell 1996)
Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction. (PubMed id 19996314)^{1, 2, 9} Graziani A.... Groschner K. (J. Biol. Chem. 2010)
Cloning and expression of the human transient receptor potential 4 (TRP4) gene: localization and functional expression of human TRP4 and TRP3. (PubMed id 11042129)^{1, 2, 9} McKay R.R.... Putney J.W. Jr. (Biochem. J. 2000)
The PDZ-interacting domain of TRPC4 controls its localization and surface expression in HEK293 cells. (PubMed id 12154080)^{1, 2, 9} Mery L.... Hoth M. (J. Cell Sci. 2002)
Activation of the endothelial store-operated ISOC Ca2+ channel requires interaction of protein 4.1 with TRPC4. (PubMed id 16254212)^{1, 2, 9} Cioffi D.L.... Stevens T. (Circ. Res. 2005)
The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5. (PubMed id 20164195)^{1, 2, 9} Miehe S....Strubing C. (J. Biol. Chem. 2010)
Functional differences between TRPC4 splice variants. (PubMed id 11713258)^{1, 2, 9} Schaefer M.... Schultz G. (J. Biol. Chem. 2002)
Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)^{1, 4} Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
Association study of TRPC4 as a candidate gene for generalized epilepsy with photosensitivity. (PubMed id 20574736)^{1, 4} von Spiczak S....Stephani U. (Neuromolecular Med. 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7223	HGNC: 12336	AceView: TRPC4	Ensembl:ENSG00000133107	euGenes: HUgn7223
ECgene: TRPC4	H-InvDB: TRPC4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TRPC4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TRPC4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TRPC4 gene:
Search GeneIP for patents involving TRPC4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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