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TRPC4 Gene

protein-coding   GIFtS: 66
GCID: GC13M038210

Transient Receptor Potential Cation Channel, Subfamily C,...

  Search for TRPC4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transient Receptor Potential Cation Channel, Subfamily C, Member 41 2     Short Transient Receptor Potential Channel 42
Trp-Related Protein 42 3     TrpC43
TRP42 5     hTrp-43
HTRP-42     hTrp43
HTRP42     

External Ids:    HGNC: 123361   Entrez Gene: 72232   Ensembl: ENSG000001331077   OMIM: 6036515   UniProtKB: Q9UBN43   

Export aliases for TRPC4 gene to outside databases

Previous GC identifers: GC13M036197 GC13M032197 GC13M037147 GC13M036008 GC13M037108 GC13M019010


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRPC4 Gene:
This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded
protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and
tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation,
neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated
with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple
isoforms have been observed for this gene. (provided by RefSeq, Aug 2011)

GeneCards Summary for TRPC4 Gene:
TRPC4 (transient receptor potential cation channel, subfamily C, member 4) is a protein-coding gene. GO annotations related to this gene include beta-catenin binding and store-operated calcium channel activity. An important paralog of this gene is TRPC1.

UniProtKB/Swiss-Prot: TRPC4_HUMAN, Q9UBN4
Function: Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell
contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger
system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an
enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion

summary for TRPC4 Gene:
The classical or canonical transient receptor potential (TRPC) channels are the subfamily most closely
related to the founding member of the TRP family, the Drosophila TRP channel. TRPC channels have seven TRPC
genes that encode the channel protein; these are named TRPC1-7 (TRPC2 is a pseudogene in humans). They are
non-selective, calcium permeable cation channels; however their permeability ratio of calcium/sodium ions
varies between different members of the family. Generally, TRPC channels can be activated by phospholipase
C, with some members (TRPC3, -6 and -7) being activated directly by diacylglycerol (DAG).

Gene Wiki entry for TRPC4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NC_018924.2  NT_024524.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRPC4 gene promoter:
         HOXA9B   HOXA9   Egr-3   Egr-1   FOXD1   HSF1 (long)   CREB   deltaCREB   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRPC4 promoter sequence
   Search Chromatin IP Primers for TRPC4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRPC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q13.3   Ensembl cytogenetic band:  13q13.3   HGNC cytogenetic band: 13q13.3

TRPC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRPC4 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M038210:  view genomic region     (about GC identifiers)

Start:
38,210,773 bp from pter      End:
38,444,562 bp from pter
Size:
233,790 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRPC4_HUMAN, Q9UBN4 (See protein sequence)
Recommended Name: Short transient receptor potential channel 4  
Size: 977 amino acids; 112101 Da
Subunit: Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC1 and/or TRPC5. Isoform
alpha but not isoform beta associates with inositol 1,4,5-trisphosphate receptor (ITPR). Interacts with (via
PDZ-binding domain) with SLC9A3R1/NHERF. Interacts with MX1 and RNF24. Interacts (via CIRB domain) with SESTD1
(via spectrin 1 repeat). Interacts with CDH5 and CTNNB1. Interacts with SPTAN1 (via C-terminal spectrin repeats)
and SPTBN5 (via C-terminus). Interacts (via protein 4.1-binding domain) with EPB41L2
Miscellaneous: The interaction with spectrin is important in controlling the translocation of TRPC4 channels to
the plasma membrane following EGF stimulation
Miscellaneous: The cell membrane presentation, the calcium entry function and the interaction with junctional
proteins (CTNNB1 and CDH5) are controlled by endothelial cell-cell contacts
Secondary accessions: B1ALE0 B1ALE1 B1ALE2 Q15721 Q3SWS6 Q96P03 Q96P04 Q96P05 Q9UIB0 Q9UIB1
Q9UIB2
Alternative splicing: 7 isoforms:  Q9UBN4-1   Q9UBN4-2   Q9UBN4-3   Q9UBN4-4   Q9UBN4-5   Q9UBN4-6   Q9UBN4-7   

Explore the universe of human proteins at neXtProt for TRPC4: NX_Q9UBN4

Explore proteomics data for TRPC4 at MOPED

Post-translational modifications: 

  • Phosphorylation modulates TRPC channel function by regulating the level of TRPC4 at the cell surface and by
    increasing the association with SLC9A3R1/NHERF1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TRPC4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001129427.1  NP_001129428.1  NP_001129429.1  NP_001129430.1  NP_003297.1  NP_057263.1  

    ENSEMBL proteins: 
     ENSP00000369027   ENSP00000369001   ENSP00000435969   ENSP00000348025   ENSP00000351264  
     ENSP00000368995   ENSP00000369003   ENSP00000342580   ENSP00000414316   ENSP00000410133  
    Reactome Protein details: Q9UBN4

    TRPC4 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for TRPC4
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    Novus Biologicals TRPC4 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRPC4

     
    Search eBioscience for Proteins for TRPC4 

    TRPC4 Antibody Products:

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    Search eBioscience for ELISAs for TRPC4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TRP: Voltage-gated ion channels / Transient receptor potential cation channels
    ANKRD: Ankyrin repeat domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: TRPC4
    Transient Receptor Potential channels

    Selected InterPro protein domains (see all 7):
     IPR005460 TRPC4_channel
     IPR002153 TRPC_channel
     IPR005821 Ion_trans_dom
     IPR004729 TRP_channel
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry Q9UBN4

    ProtoNet protein and cluster: Q9UBN4

    4 Blocks protein domains:
    IPB002110 Ankyrin repeat signature
    IPB002153 Transient receptor potential family signature
    IPB005460 Transient receptor potential channel 4 signature
    IPB013555 Transient receptor ion channel II


    UniProtKB/Swiss-Prot: TRPC4_HUMAN, Q9UBN4
    Domain: The protein 4.1-binding domain (654-685) is required for binding to EPB41L2 and channel activation
    Domain: The calmodulin- and inositol 1,4,5-trisphosphate receptor-binding (CIRB) domain (695-724) is sufficient
    for the interaction with SESTD1
    Domain: The spectrin-binding domain (730-758) is required for binding to SPTAN1 and SPTBN5
    Similarity: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily
    Similarity: Contains 4 ANK repeats


    Find genes that share domains with TRPC4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRPC4_HUMAN, Q9UBN4
    Function: Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell
    contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger
    system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an
    enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005262calcium channel activity ----
    GO:0005515protein binding IPI15757897
    GO:0008013beta-catenin binding IPI19996314
    GO:0015279store-operated calcium channel activity IMP16254212
         
    Find genes that share ontologies with TRPC4           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for TRPC4:
     Low eccentricity cells  Synthetic lethal with c-Myc af  Synthetic lethal with cisplati 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Trpc4):
     cardiovascular system  muscle  nervous system  normal 

    Find genes that share phenotypes with TRPC4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Trpc4tm1Bni for TRPC4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRPC4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRPC4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRPC4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRPC4

    miRNA
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    miRTarBase miRNAs that target TRPC4:
    hsa-mir-26b-5p (MIRT029916)

    Block miRNA regulation of human, mouse, rat TRPC4 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate TRPC4:
    hsa-miR-187* hsa-miR-300 hsa-miR-1283 hsa-miR-101 hsa-miR-381
    SwitchGear 3'UTR luciferase reporter plasmidTRPC4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRPC4
    Predesigned siRNA for gene silencing in human, mouse, rat TRPC4

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): TRPC4 (NM_016179)
    Sino Biological Human cDNA Clone for TRPC4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRPC4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPC4

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRPC4_HUMAN, Q9UBN4: Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
    Note=Enhanced insertion into the cell membrane after activation of the EGF receptor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    endoplasmic reticulum2
    cytosol1
    extracellular1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005901caveola IEA--
    GO:0005911colocalizes with cell-cell junction IDA19996314
    GO:0009986cell surface IDA19996314
    GO:0016020membrane ----

    Find genes that share ontologies with TRPC4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TRPC4 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    2Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58
    3Netrin-1 signaling
    Netrin-1 signaling
    Role of second messengers in netrin-1 signaling0.00
    4CREB Pathway
    Intracellular Calcium Signaling0.50
    5Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47


    Find genes that share SuperPaths with TRPC4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TRPC4
        Intracellular Calcium Signaling


    2 Reactome Pathways for TRPC4
        TRP channels
    Role of second messengers in netrin-1 signaling


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRPC4
    Interactions:

        GeneGlobe Interaction Network for TRPC4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRPC4 (Q9UBN41, 2, 3 ENSP000003690034) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITPR2Q145712, 3, ENSP000003707444MINT-14530 MINT-14529 I2D: score=3 STRING: ENSP00000370744
    MX1P205911, 3, ENSP000003815994EBI-929504,EBI-929476 I2D: score=3 STRING: ENSP00000381599
    ITPR3Q145733, ENSP000003634354I2D: score=2 STRING: ENSP00000363435
    SLC9A3R1O147453, ENSP000002626134I2D: score=2 STRING: ENSP00000262613
    TRPC5Q9UL623, ENSP000002628394I2D: score=2 STRING: ENSP00000262839
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0006816calcium ion transport TAS8646775
    GO:0007411axon guidance TAS--
    GO:0014051gamma-aminobutyric acid secretion IEA--
    GO:0034220ion transmembrane transport TAS--

    Find genes that share ontologies with TRPC4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for TRPC4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Pyr3Selective TRPC3 channel blocker[1160514-60-2]
    GsMTx4TRPC1 and TRPC6 blocker; inhibits mechanosensitive ion channels--
    ML 204Selective TRPC4 blocker[5465-86-1]

    1 HMDB Compound for TRPC4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    5 IUPHAR Ligands for TRPC4 (TRPC4)    About this table
    LigandTypeActionAffinityPubmed IDs
    ML204
    Channel blockerNone5.521795696
    SKF96365
    Channel blockerNone5.5--
    La3+
    Channel blockerNone5.5--
    2-APB
    Channel blockerNone5.5--
    niflumic acid
    Channel blockerNone5.5--

    9 Novoseek inferred chemical compound relationships for TRPC4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    1-oleoyl-2-acetyl-sn-glycerol 71.8 1 12721302 (1)
    thapsigargin 70.8 3 12736151 (1), 11830588 (1), 19523685 (1)
    calcium 58.4 31 16254212 (2), 15229105 (2), 15546997 (2), 19523685 (2) (see all 17)
    inositol 1,4,5 trisphosphate 45 2 15654973 (1), 20164195 (1)
    carbachol 37.4 5 11830588 (4)
    atp 0 11 15229105 (3)
    nitric oxide 0 2 16998480 (1)
    lipid 0 3 16270640 (1), 20164195 (1)
    tyrosine 0 1 15902430 (1)



    Find genes that share compounds with TRPC4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRPC4 gene (6 alternative transcripts): 
    NM_001135955.1  NM_001135956.1  NM_001135957.1  NM_001135958.1  NM_003306.1  NM_016179.2  

    Unigene Cluster for TRPC4:

    Transient receptor potential cation channel, subfamily C, member 4
    Hs.262960  [show with all ESTs]
    Unigene Representative Sequence: BX648312
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379705(uc010abv.3 uc001uwt.3 uc001uws.3 uc010tey.2 uc010abw.3 uc010aby.3)
    ENST00000379679 ENST00000488717 ENST00000355779 ENST00000358477 ENST00000379673
    ENST00000494529 ENST00000379681(uc010abx.3) ENST00000338947 ENST00000447043
    ENST00000426868
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    SwitchGear 3'UTR luciferase reporter plasmidTRPC4 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 6): TRPC4 (NM_016179)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPC4
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      QuantiFast Probe-based Assays in human, mouse, rat TRPC4

    Additional mRNA sequence: 

    AF063822.1 AF063823.1 AF063824.1 AF063825.1 AF175406.1 AF421358.1 AF421359.1 AF421360.1 
    AF421362.1 AK312524.1 BC104725.1 BC105641.1 BC105917.1 BX648312.1 U40983.1 

    4 DOTS entries:

    DT.40260695  DT.92419684  DT.92419686  DT.40303044 

    Selected AceView cDNA sequences (see all 25):

    AF421362 AF421358 BP378220 BX092795 NM_016179 AF175406 AF421359 AF421361 
    U40983 AF421360 BX648312 AI383963 BP376494 BP376399 AF063825 AF063822 
    BP378906 AF063824 AF063823 C02173 AA629948 AI082121 BG189786 BG205685 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TRPC4 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b
    SP1:                                                              -                                       
    SP2:                                                              -                 -     -               
    SP3:                                                              -                                       
    SP4:                                                        -     -                                       
    SP5:                                            -                 -                                       


    ECgene alternative splicing isoforms for TRPC4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRPC4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTAAATAAG
    TRPC4 Expression
    About this image


    TRPC4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Epithelial Cells
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
    TRPC4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRPC4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.262960

    UniProtKB/Swiss-Prot: TRPC4_HUMAN, Q9UBN4
    Tissue specificity: Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and
    brain. Expressed in endothelial cells. Isoform alpha was found to be the predominant isoform. Isoform beta was
    not found in pancreas and brain

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TRPC4 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trpc41 , 5 transient receptor potential cation channel, subfamily more1, 5 88.25(n)1
    97.33(a)1
      3 (25.43 cM)5
    220661  NM_016984.31  NP_058680.11 
     541560575 
    chicken
    (Gallus gallus)
    Aves TRPC41 transient receptor potential cation channel, subfamily more 79.12(n)
    85.32(a)
      418895  XM_417089.4  XP_417089.2 
    lizard
    (Anolis carolinensis)
    Reptilia TRPC46
    transient receptor potential cation channel, subfa...
    83(a)
    1 ↔ 1
    2(82170608-82275900)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia trpc41 transient receptor potential cation channel, subfamily more 74.99(n)
    84.31(a)
      100485338  XM_002939583.2  XP_002939629.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.240842 Danio rerio cDNA clone IMAGE2643303 74.53(n)    BC058321.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta trpgamma1 , 3 calcium ion transport calcium channel3
    trpgamma1
    52(a)
    (best of 3)3
    55.71(n)1
    55.66(a)1
      36A93
    349911  NM_135958.41  NP_609802.11 
    worm
    (Caenorhabditis elegans)
    Secernentea trp-13
    trp-21
    Transient-receptor-potential (trp)
    protein3
    trp-21
    41(a)3
    52.37(n)1
    48.24(a)1
      III(8607645-8614376)3
    1920561  NM_001027532.31  NP_001022703.11 


    ENSEMBL Gene Tree for TRPC4 (if available)
    TreeFam Gene Tree for TRPC4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRPC4 gene
    TRPC12  TRPC72  TRPC62  TRPC52  TRPC32  
    6 SIMAP similar genes for TRPC4 using alignment to 4 protein entries:     TRPC4_HUMAN (see all proteins):
    TRPC5    TRPC1    TRP7    TRPC6    TRPC7    TRPC3

    Find genes that share paralogs with TRPC4           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TRPC4
    PGOHUM00000250394


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRPC4 (see all 5050)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364524
    A breast cancer sample4--see VAR_0364522 E K mis40--------
    rs1165274821,2
    Cuntested119157983(+) TCTTCG/AGTCAG 11 /T syn1 int12Minor allele frequency- A:0.00EA NA 4754
    rs1503192361,2
    C--19016356(+) CTTTC-/TTTTTT 6 -- int10--------
    rs113456291,2
    C--19022633(+) AGGTAT/-TTTTT 6 -- int1 trp31Minor allele frequency- -:0.50CSA 2
    rs1435607191,2
    C--19039634(+) CCAGG-/AAAAAA 6 -- int10--------
    rs113892201,2
    C--19064491(+) TTTTT-/TCTGCC 6 -- int1 trp30--------
    rs3676057011,2
    C--19066758(+) GTTAA-/AGGGGTTA 6 -- cds10--------
    rs742174271,2
    F--19069808(-) GTCTGC/TCACCA 6 -- int13Minor allele frequency- T:0.50NA 6
    rs770069601,2
    C--19069831(-) CCCTGG/AAAATG 6 -- int11Minor allele frequency- A:0.50NA 2
    rs763588201,2
    C--19069849(+) CTTTAC/TAAAAC 6 -- int11Minor allele frequency- T:0.00NA 2

    HapMap Linkage Disequilibrium report for TRPC4 (38210773 - 38444562 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TRPC4 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2668113CNV Deletion23128226
    esv2661529CNV Deletion23128226
    nsv64068CNV Insertion16902084
    esv1262429CNV Insertion17803354
    nsv64072CNV Insertion16902084
    esv268730CNV Insertion20981092
    esv34109CNV Loss18971310
    nsv899995CNV Loss21882294
    nsv826617CNV Loss20364138
    esv33246CNV Gain17666407

    Human Gene Mutation Database (HGMD): TRPC4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRPC4
    DNA2.0 Custom Variant and Variant Library Synthesis for TRPC4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603651    OMIM disorders: --


    Find genes that share disorders with TRPC4           About GenesLikeMe

    Genetic Association Database (GAD): TRPC4
    Human Genome Epidemiology (HuGE) Navigator: TRPC4 (3 documents)

    Export disorders for TRPC4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRPC4 gene, integrated from 10 sources (see all 104):
    (articles sorted by number of sources associating them with TRPC4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. (PubMed id 8646775)1, 2, 3 Zhu X....Birnbaumer L. (Cell 1996)
    2. Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction. (PubMed id 19996314)1, 2, 9 Graziani A.... Groschner K. (J. Biol. Chem. 2010)
    3. Cloning and expression of the human transient receptor potential 4 (TRP4) gene: localization and functional expression of human TRP4 and TRP3. (PubMed id 11042129)1, 2, 9 McKay R.R.... Putney J.W. Jr. (Biochem. J. 2000)
    4. The PDZ-interacting domain of TRPC4 controls its localization and surface expression in HEK293 cells. (PubMed id 12154080)1, 2, 9 Mery L.... Hoth M. (J. Cell Sci. 2002)
    5. Activation of the endothelial store-operated ISOC Ca2+ channel requires interaction of protein 4.1 with TRPC4. (PubMed id 16254212)1, 2, 9 Cioffi D.L.... Stevens T. (Circ. Res. 2005)
    6. The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5. (PubMed id 20164195)1, 2, 9 Miehe S....Strubing C. (J. Biol. Chem. 2010)
    7. Functional differences between TRPC4 splice variants. (PubMed id 11713258)1, 2, 9 Schaefer M.... Schultz G. (J. Biol. Chem. 2002)
    8. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    10. Association study of TRPC4 as a candidate gene for generalized epilepsy with photosensitivity. (PubMed id 20574736)1, 4 von Spiczak S....Stephani U. (Neuromolecular Med. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7223 HGNC: 12336 AceView: TRPC4 Ensembl:ENSG00000133107 euGenes: HUgn7223
    ECgene: TRPC4 H-InvDB: TRPC4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRPC4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRPC4 gene:
    Search GeneIP for patents involving TRPC4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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