Aliases for TRPC3 Gene
External Ids for TRPC3 Gene
Previous GeneCards Identifiers for TRPC3 Gene
The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for TRPC3 Gene
TRPC3 (Transient Receptor Potential Cation Channel Subfamily C Member 3) is a Protein Coding gene. Diseases associated with TRPC3 include Spinocerebellar Ataxia 41 and Spinocerebellar Ataxia 14. Among its related pathways are Axon guidance and Trk receptor signaling mediated by PI3K and PLC-gamma. GO annotations related to this gene include binding and calcium channel activity. An important paralog of this gene is TRPC6.
UniProtKB/Swiss-Prot for TRPC3 Gene
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.