Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TRPC3 Gene

protein-coding   GIFtS: 64
GCID: GC04M122800

Transient Receptor Potential Cation Channel, Subfamily C,...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Transient Receptor Potential Cation Channel, Subfamily C, Member 31 2     Transient Receptor Potential Cation Channel Subfamily C Member 3 Variant C2
Transient Receptor Protein 32 3     TRP-33
TRP32 3     TrpC33
hTrp-32 3     hTrp33
Short Transient Receptor Potential Channel 32     

External Ids:    HGNC: 123351   Entrez Gene: 72222   Ensembl: ENSG000001387417   OMIM: 6023455   UniProtKB: Q135073   

Export aliases for TRPC3 gene to outside databases

Previous GC identifers: GC04M123725 GC04M123079 GC04M123193 GC04M123259 GC04M123158 GC04M118526


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TRPC3 Gene:
The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium
and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine
kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium
stores. Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq,
Oct 2011)

GeneCards Summary for TRPC3 Gene:
TRPC3 (transient receptor potential cation channel, subfamily C, member 3) is a protein-coding gene. Diseases associated with TRPC3 include scheuermann's disease, and malignant hypertension. GO annotations related to this gene include calcium channel activity and inositol 1,4,5 trisphosphate binding. An important paralog of this gene is TRPC4.

UniProtKB/Swiss-Prot: TRPC3_HUMAN, Q13507
Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated
by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled
receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C,
and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium
store depletion

Gene Wiki entry for TRPC3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRPC3 gene promoter:
         CREB   AML1a   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRPC3 promoter sequence
   Search Chromatin IP Primers for TRPC3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRPC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q27   Ensembl cytogenetic band:  4q27   HGNC cytogenetic band: 4q27

TRPC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRPC3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M122800:  view genomic region     (about GC identifiers)

Start:
122,800,182 bp from pter      End:
122,872,909 bp from pter
Size:
72,728 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TRPC3_HUMAN, Q13507 (See protein sequence)
Recommended Name: Short transient receptor potential channel 3  
Size: 836 amino acids; 96009 Da
Subunit: Interacts with TRPC1, ITPR1, ITPR3, MX1 and RNF24. Interacts with JPH2; the interaction is involved in
maintaining Ca(2+) homeostasis in skeletal muscle and is mediated by JPH2 'Ser-165' phosphorylation
Secondary accessions: A7VJS1 E9PCJ9 O00593 Q15660 Q52M35 Q5G1L5
Alternative splicing: 3 isoforms:  Q13507-1   Q13507-2   Q13507-3   

Explore the universe of human proteins at neXtProt for TRPC3: NX_Q13507

Explore proteomics data for TRPC3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn404
  • Modification sites at PhosphoSitePlus

  • See TRPC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001124170.1  NP_003296.1  

    ENSEMBL proteins: 
     ENSP00000264811   ENSP00000368966   ENSP00000423866   ENSP00000426899   ENSP00000422214  
    Reactome Protein details: Q13507

    TRPC3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TRPC3
    OriGene Protein Over-expression Lysate for TRPC3
    OriGene MassSpec for TRPC3
    OriGene Custom Protein Services for TRPC3
    GenScript Custom Purified and Recombinant Proteins Services for TRPC3
    Novus Biologicals TRPC3 Proteins
    Novus Biologicals TRPC3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRPC3

    TRPC3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TRPC3
    OriGene Custom Antibody Services for TRPC3
    Novus Biologicals TRPC3 Antibodies
    Abcam antibodies for TRPC3
    Cloud-Clone Corp. Antibodies for TRPC3
    ThermoFisher Antibodies for TRPC3
    LSBio Antibodies in human, mouse, rat for TRPC3

    TRPC3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TRPC3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRPC3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TRPC3
    Cloud-Clone Corp. CLIAs for TRPC3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    TRP: Voltage-gated ion channels / Transient receptor potential cation channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: TRPC3
    Transient Receptor Potential channels

    Selected InterPro protein domains (see all 7):
     IPR002153 TRPC_channel
     IPR005821 Ion_trans_dom
     IPR004729 TRP_channel
     IPR002110 Ankyrin_rpt
     IPR005459 TRPC3_channel

    Graphical View of Domain Structure for InterPro Entry Q13507

    ProtoNet protein and cluster: Q13507

    4 Blocks protein domains:
    IPB002110 Ankyrin repeat signature
    IPB002153 Transient receptor potential family signature
    IPB005459 Transient receptor potential channel 3 signature
    IPB013555 Transient receptor ion channel II


    UniProtKB/Swiss-Prot: TRPC3_HUMAN, Q13507
    Similarity: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC3 sub-subfamily
    Similarity: Contains 4 ANK repeats


    TRPC3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRPC3_HUMAN, Q13507
    Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated
    by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled
    receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C,
    and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium
    store depletion

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005262calcium channel activity TAS9930701
    GO:0005488binding ----
    GO:0005515protein binding IPI10611319
    GO:0015279store-operated calcium channel activity TAS9215637
         
    TRPC3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TRPC3:
     Decreased DCP1a protein expres 

         13 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Trpc3):
     adipose tissue  behavior/neurological  cardiovascular system  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  limbs/digits/tail  mortality/aging  nervous system 
     other  skeleton  vision/eye 

    TRPC3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TRPC3: Trpc3tm1.1Bmil Trpc3tm1.1Akon

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRPC3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRPC3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRPC3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRPC3

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRPC3:
    hsa-mir-196a-5p (MIRT026076), hsa-mir-221-3p (MIRT024166), hsa-mir-19b-3p (MIRT031132), hsa-mir-130b-3p (MIRT020161)

    Block miRNA regulation of human, mouse, rat TRPC3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRPC3 (see all 36):
    hsa-miR-301a hsa-miR-650 hsa-miR-218 hsa-miR-548m hsa-miR-23a hsa-miR-3612 hsa-miR-130b hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmidTRPC3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRPC3
    Predesigned siRNA for gene silencing in human, mouse, rat TRPC3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRPC3

    Clone
    Products:
         
    OriGene clones in human, mouse for TRPC3 (see all 11)
    OriGene ORF clones in mouse, rat for TRPC3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TRPC3 (NM_003305)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRPC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPC3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TRPC3
    Browse ESI BIO Cell Lines and PureStem Progenitors for TRPC3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TRPC3_HUMAN, Q13507: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum2
    extracellular2
    cytoskeleton1
    cytosol1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA9368034
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    TRPC3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TRPC3 About   (see all 16)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Platelet homeostasis
    Platelet homeostasis
    Platelet calcium homeostasis0.00
    Elevation of cytosolic Ca2+ levels0.00
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    5Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TRPC3
        Intracellular Calcium Signaling

    1 GeneGo (Thomson Reuters) Pathway for TRPC3
        Transcription Role of VDR in regulation of genes involved in osteoporosis

    1 BioSystems Pathway for TRPC3
        Trk receptor signaling mediated by PI3K and PLC-gamma

    4 Reactome Pathways for TRPC3
        TRP channels
    Effects of PIP2 hydrolysis
    Role of second messengers in netrin-1 signaling
    Elevation of cytosolic Ca2+ levels



    TRPC3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including TRPC3: 
              Neuronal Ion Channels in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TRPC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRPC3 (Q135071, 3 ENSP000003689664) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITPR3Q145731, 3, ENSP000003634354EBI-520807,EBI-351055 I2D: score=4 STRING: ENSP00000363435
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    MX1P205911, 3, ENSP000003815994EBI-520807,EBI-929476 I2D: score=3 STRING: ENSP00000381599
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0006816calcium ion transport TAS9215637
    GO:0007411axon guidance TAS--
    GO:0007596blood coagulation TAS--
    GO:0007602phototransduction TAS9215637

    TRPC3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRPC3

    Selected HMDB Compounds for TRPC3 (see all 844)    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----

    10 IUPHAR Ligands for TRPC3 (TRPC3)    About this table
    LigandTypeActionAffinityPubmed IDs
    Gd3+
    Pore BlockerAntagonist710970899
    BTP2
    Pore BlockerAntagonist6.715647288
    La3+
    Pore BlockerAntagonist5.410970899
    2-APB
    Pore BlockerAntagonist515933213
    SKF96365
    Channel blockerNone5--
    Pyr3
    Channel blockerNone519289841
    ACAA
    Channel blockerNone5--
    KB-R7943
    Channel blockerNone5--
    OAG
    ActivatorAgonist59930701
    Ni2+
    Channel blockerNone5--

    Selected Novoseek inferred chemical compound relationships for TRPC3 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2-aminoethoxydiphenylborane 87.7 2 20068131 (1), 17351372 (1)
    1-oleoyl-2-acetyl-sn-glycerol 83.5 12 17351372 (3), 10882720 (2), 15533987 (2), 16522635 (2) (see all 5)
    skf 96365 83.3 1 15972814 (1)
    inositol 1,4,5 trisphosphate 77.3 15 12606542 (4), 11553786 (2), 12730194 (2), 11248050 (2) (see all 8)
    thapsigargin 74.1 9 11042129 (1), 9417057 (1), 11600493 (1), 12736151 (1) (see all 8)
    calcium 65.5 68 9298988 (7), 18431718 (5), 17569672 (3), 12736256 (3) (see all 28)
    2-amino-4-phosphonobutyric acid 64.8 1 15933213 (1)
    kt 5823 52.5 2 14983059 (1), 16331690 (1)
    calmidazolium 48.2 4 11248050 (1)
    carbachol 44.5 12 18755685 (3), 11830588 (2), 19332491 (1), 14736881 (1) (see all 5)



    TRPC3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TRPC3 gene (2 alternative transcripts): 
    NM_001130698.1  NM_003305.2  

    Unigene Cluster for TRPC3:

    Transient receptor potential cation channel, subfamily C, member 3
    Hs.150981  [show with all ESTs]
    Unigene Representative Sequence: AY865574
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264811(uc003ief.2 uc011cgl.1) ENST00000379645(uc010inr.2 uc003ieg.2)
    ENST00000506449 ENST00000513531 ENST00000502968
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TRPC3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRPC3 (see all 36):
    hsa-miR-301a hsa-miR-650 hsa-miR-218 hsa-miR-548m hsa-miR-23a hsa-miR-3612 hsa-miR-130b hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmidTRPC3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TRPC3
    Predesigned siRNA for gene silencing in human, mouse, rat TRPC3
    Clone
    Products:
         
    OriGene clones in human, mouse for TRPC3 (see all 11)
    OriGene ORF clones in mouse, rat for TRPC3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TRPC3 (NM_003305)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRPC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPC3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TRPC3
    OriGene qSTAR qPCR primer pairs in human, mouse for TRPC3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRPC3
      QuantiTect SYBR Green Assays in human, mouse, rat TRPC3
      QuantiFast Probe-based Assays in human, mouse, rat TRPC3

    Additional mRNA sequence: 

    AB255423.1 AB255424.1 AY865574.1 BC093682.1 BC093684.1 BC143239.1 KC207570.1 X89068.1 
    Y13758.1 

    3 DOTS entries:

    DT.409154  DT.100744119  DT.121225219 

    17 AceView cDNA sequences:

    AW296897 AW207876 AW014163 R34716 BX281448 AI655379 BF516575 BF438538 
    Y13758 X89068 NM_003305 BF512869 AI088264 U47050 AA248593 D61017 
    R49588 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TRPC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAATGCATT
    TRPC3 Expression
    About this image

    TRPC3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRPC3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.150981

    UniProtKB/Swiss-Prot: TRPC3_HUMAN, Q13507
    Tissue specificity: Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine,
    lung, prostate, placenta and testis

        Pathway & Disease-focused RT2 Profiler PCR Array including TRPC3: 
              Neuronal Ion Channels in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TRPC3
    OriGene qSTAR qPCR primer pairs in human, mouse for TRPC3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRPC3
    QuantiTect SYBR Green Assays in human, mouse, rat TRPC3
    QuantiFast Probe-based Assays in human, mouse, rat TRPC3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for TRPC3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trpc31 , 5 transient receptor potential cation channel, subfamily more1, 5 87.14(n)1
    94.4(a)1
      3 (17.93 cM)5
    220651  NM_019510.21  NP_062383.21 
     366204825 
    chicken
    (Gallus gallus)
    Aves TRPC31 transient receptor potential cation channel, subfamily more 81.84(n)
    93.03(a)
      374153  NM_001257279.1  NP_001244208.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRPC36
    transient receptor potential cation channel, subfa...
    89(a)
    1 ↔ 1
    5(138927257-139009169)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia trpc31 transient receptor potential cation channel, subfamily more 76.78(n)
    90.22(a)
      100490905  XM_002941893.2  XP_002941939.2 
    zebrafish
    (Danio rerio)
    Actinopterygii TRPC36
    transient receptor potential cation channel, subfa...
    83(a)
    1 ↔ 1
    4(29588189-29590656) ENSDARG00000087463


    ENSEMBL Gene Tree for TRPC3 (if available)
    TreeFam Gene Tree for TRPC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TRPC3 gene
    TRPC42  TRPC12  TRPC72  TRPC62  TRPC52  
    5 SIMAP similar genes for TRPC3 using alignment to 7 protein entries:     TRPC3_HUMAN (see all proteins):
    TRPC7    TRP7    TRPC6    TRPC5    TRPC4

    TRPC3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TRPC3
    PGOHUM00000250393


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TRPC3 (see all 1567)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs106248871,2
    C--118570944(+) gacac-/AGAG  
            
    agaga
    2 -- int1 trp30--------
    rs1914585251,2
    --118570956(+) AGAGAC/GAGAGA 2 -- int10--------
    rs715991611,2
    C--118574256(+) TTTTC-/TTTTTT 2 -- int12Minor allele frequency- T:0.25NA CSA 4
    rs342527701,2
    C--118583264(+) GTGGG-/GTGTGTG 1 -- int10--------
    rs719787451,2
    C--118583264(+) GTGGG-/GTGT  
            
    GTGTG
    1 -- int10--------
    rs780385371,2
    --118583265(+) TGGGGG/TGTGTG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs340606751,2
    C--118591031(+) CCCCCC/-TAGAT 1 -- int11Minor allele frequency- -:0.50NA 2
    rs715991631,2
    C--118591759(+) TAGTAT/-TTTTA 1 -- int11Minor allele frequency- -:0.50NA 2
    rs2002365651,2
    C--118596219(+) TTTTT-/CTCCCT 1 -- int10--------
    rs770554871,2
    --118596220(+) TTTTTC/TCCCTC 1 -- int10--------

    HapMap Linkage Disequilibrium report for TRPC3 (122800182 - 122872909 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TRPC3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv24000CNV Loss19812545

    Human Gene Mutation Database (HGMD): TRPC3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRPC3
    DNA2.0 Custom Variant and Variant Library Synthesis for TRPC3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602345    OMIM disorders: --

    Selected diseases for TRPC3 (see all 25):    About MalaCards
    scheuermann's disease    malignant hypertension    lambert-eaton myasthenic syndrome    essential hypertension
    hypercalcemia    williams-beuren syndrome    myasthenia gravis    hypertension
    narcolepsy    cerebellar ataxia    osteoporosis    bipolar disorder
    kidney disease    astrocytoma    diabetes mellitus    cerebritis
    endotheliitis    ataxia    hypoxia    ovarian cancer


    TRPC3 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for TRPC3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    airways disease 21.3 1 16574942 (1)
    essential hypertension 14.7 5 17351372 (3), 18177730 (2)

    Genetic Association Database (GAD): TRPC3
    Human Genome Epidemiology (HuGE) Navigator: TRPC3 (1 document)

    Export disorders for TRPC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TRPC3 gene, integrated from 10 sources (see all 175):
    (articles sorted by number of sources associating them with TRPC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. (PubMed id 8646775)1, 2, 3 Zhu X....Birnbaumer L. (Cell 1996)
    2. Receptor-activated Ca2+ influx via human Trp3 stably expressed in human embryonic kidney (HEK)293 cells. Evidence for a non-capacitative Ca2+ entry. (PubMed id 9417057)1, 2, 9 Zhu X.... Birnbaumer L. (J. Biol. Chem. 1998)
    3. The TRPC3 channel has a large internal chamber surrounded by signal sensing antennas. (PubMed id 17258231)1, 2, 9 Mio K.... Sato C. (J. Mol. Biol. 2007)
    4. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    5. Molecular cloning of TRPC3a, an N-terminally extended, store-operated variant of the human C3 transient receptor potential channel. (PubMed id 15728370)1, 2 Yildirim E.... Birnbaumer L. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    6. MxA, a member of the dynamin superfamily, interacts with the ankyrin- like repeat domain of TRPC. (PubMed id 15757897)1, 2 Lussier M.P.... Boulay G. (J. Biol. Chem. 2005)
    7. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. (PubMed id 16382100)1, 3 Clapham D.E....Schultz G. (Pharmacol. Rev. 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Modulation of Ca(2+) entry by polypeptides of the inositol 1,4, 5- trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca(2+) entry. (PubMed id 10611319)1, 2 Boulay G.... Birnbaumer L. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    10. Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. (PubMed id 9930701)1, 2 Hofmann T....Schultz G. (Nature 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7222 HGNC: 12335 AceView: TRPC3 Ensembl:ENSG00000138741 euGenes: HUgn7222
    ECgene: TRPC3 H-InvDB: TRPC3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TRPC3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TRPC3 gene:
    Search GeneIP for patents involving TRPC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TRPC3   OriGene RNAi products in human, mouse, rat for TRPC3  
     OriGene qPCR primer pairs and template standards for TRPC3   OriGene Protein Over-expression Lysate for TRPC3  
     OriGene MassSpec something-or-other for TRPC3   OriGene clones in human, mouse for TRPC3  
     OriGene qSTAR qPCR primer pairs in human, mouse for TRPC3   OriGene Purified Protein for TRPC3  
     OriGene ORF clones in mouse, rat for TRPC3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TRPC3   OriGene Custom Protein Services for TRPC3  

     
     
     Block miRNA regulation of human, mouse, rat TRPC3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TRPC3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRPC3 Predesigned siRNA for gene silencing in human, mouse, rat TRPC3
     QuantiFast Probe-based Assays in human, mouse, rat TRPC3 QuantiTect SYBR Green Assays in human, mouse, rat TRPC3
     PCR Arrays including human, mouse, rat TRPC3 Search Chromatin IP Primers for TRPC3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRPC3  GeneGlobe Interaction Network for TRPC3
     Regulatory tfbs in TRPC3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TRPC3 GenScript cDNA clones with any tag delivered in your preferred vector for TRPC3
     GenScript Custom Assay Services for TRPC3 GenScript Custom overexpressing Cell Line Services for TRPC3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TRPC3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TRPC3 antibodies
     TRPC3 proteins
     TRPC3 lysates
     Antibodies for TRPC3
     See all of Abcam's Antibodies, Kits and Proteins for TRPC3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TRPC3
     Antibodies for TRPC3
     ELISAs for TRPC3
     CLIAs for TRPC3



     Browse ESI BIO Cell Lines and PureStem Progenitors for TRPC3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC3
     SwitchGear 3'UTR luciferase reporter plasmids for TRPC3
     SwitchGear Promoter luciferase reporter plasmids for TRPC3
     ThermoFisher Antibodies for TRPC3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPC3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRPC3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRPC3
     LSBio Antibodies in human, mouse, rat for TRPC3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TRPC3 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4