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Aliases for TRPC3 Gene

Aliases for TRPC3 Gene

  • Transient Receptor Potential Cation Channel, Subfamily C, Member 3 2 3
  • Transient Receptor Protein 3 3 4
  • HTrp-3 3 4
  • TRP3 3 4
  • Transient Receptor Potential Cation Channel Subfamily C Member 3 Variant C 3
  • Short Transient Receptor Potential Channel 3 3
  • TRP-3 4
  • TrpC3 4
  • HTrp3 4

External Ids for TRPC3 Gene

Summaries for TRPC3 Gene

Entrez Gene Summary for TRPC3 Gene

  • The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for TRPC3 Gene

TRPC3 (Transient Receptor Potential Cation Channel, Subfamily C, Member 3) is a Protein Coding gene. Diseases associated with TRPC3 include malignant hypertension. Among its related pathways are Signaling by GPCR and L1CAM interactions. GO annotations related to this gene include calcium channel activity and inositol 1,4,5 trisphosphate binding. An important paralog of this gene is TRPC6.

UniProtKB/Swiss-Prot for TRPC3 Gene

  • Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.

Gene Wiki entry for TRPC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRPC3 Gene

Genomics for TRPC3 Gene

Genomic Location for TRPC3 Gene

Start:
121,879,027 bp from pter
End:
121,951,754 bp from pter
Size:
72,728 bases
Orientation:
Minus strand

Genomic View for TRPC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRPC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRPC3 Gene

Regulatory Elements for TRPC3 Gene

Proteins for TRPC3 Gene

  • Protein details for TRPC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13507-TRPC3_HUMAN
    Recommended name:
    Short transient receptor potential channel 3
    Protein Accession:
    Q13507
    Secondary Accessions:
    • A7VJS1
    • E9PCJ9
    • O00593
    • Q15660
    • Q52M35
    • Q5G1L5

    Protein attributes for TRPC3 Gene

    Size:
    836 amino acids
    Molecular mass:
    96009 Da
    Quaternary structure:
    • Interacts with TRPC1, ITPR1, ITPR3, MX1 and RNF24. Interacts with JPH2; the interaction is involved in maintaining Ca(2+) homeostasis in skeletal muscle and is mediated by JPH2 Ser-165 phosphorylation.

    Alternative splice isoforms for TRPC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRPC3 Gene

Proteomics data for TRPC3 Gene at MOPED

Post-translational modifications for TRPC3 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn404

Other Protein References for TRPC3 Gene

No data available for DME Specific Peptides for TRPC3 Gene

Domains for TRPC3 Gene

Gene Families for TRPC3 Gene

HGNC:
  • TRP :Voltage-gated ion channels / Transient receptor potential cation channels
IUPHAR :

UniProtKB/Swiss-Prot:

TRPC3_HUMAN
Family:
  • Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC3 sub-subfamily.:
    • Q13507
Similarity:
  • Contains 4 ANK repeats.:
    • Q13507
genes like me logo Genes that share domains with TRPC3: view

Function for TRPC3 Gene

Molecular function for TRPC3 Gene

UniProtKB/Swiss-Prot Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.

Gene Ontology (GO) - Molecular Function for TRPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005262 calcium channel activity TAS 9930701
GO:0005488 binding --
GO:0005515 protein binding IPI 10611319
GO:0015279 store-operated calcium channel activity TAS 9215637
genes like me logo Genes that share ontologies with TRPC3: view
genes like me logo Genes that share phenotypes with TRPC3: view

Animal Models for TRPC3 Gene

MGI Knock Outs for TRPC3:

miRNA for TRPC3 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TRPC3 Gene

Localization for TRPC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRPC3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRPC3 Gene COMPARTMENTS Subcellular localization image for TRPC3 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
extracellular 2
cytoskeleton 1
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TRPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 9368034
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with TRPC3: view

Pathways for TRPC3 Gene

genes like me logo Genes that share pathways with TRPC3: view

Pathways by source for TRPC3 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for TRPC3 Gene
1 Qiagen pathway for TRPC3 Gene

Gene Ontology (GO) - Biological Process for TRPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0006816 calcium ion transport TAS 9215637
GO:0006828 manganese ion transport IBA --
GO:0007411 axon guidance TAS --
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with TRPC3: view

Compounds for TRPC3 Gene

(844) HMDB Compounds for TRPC3 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available
DG(14:0/15:0/0:0)
  • Diacylglycerol(29:0)
Not Available
DG(14:0/16:0/0:0)
  • DAG(30:0)
Not Available

(10) IUPHAR Ligand for TRPC3 Gene

Ligand Type Action Affinity Pubmed IDs
BTP2 Pore Blocker Antagonist 6.7
Gd3+ Channel blocker None
La3+ Channel blocker None
2-APB Channel blocker None
SKF96365 Channel blocker None
Pyr3 Channel blocker None
ACAA Channel blocker None
KB-R7943 Channel blocker None
OAG Activator Agonist
Ni2+ Channel blocker None

(19) Novoseek inferred chemical compound relationships for TRPC3 Gene

Compound -log(P) Hits PubMed IDs
2-aminoethoxydiphenylborane 87.7 2
1-oleoyl-2-acetyl-sn-glycerol 83.5 10
skf 96365 83.3 1
inositol 1,4,5 trisphosphate 77.3 14
thapsigargin 74.1 8
genes like me logo Genes that share compounds with TRPC3: view

Transcripts for TRPC3 Gene

Unigene Clusters for TRPC3 Gene

Transient receptor potential cation channel, subfamily C, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRPC3 Gene

No ASD Table

Relevant External Links for TRPC3 Gene

GeneLoc Exon Structure for
TRPC3
ECgene alternative splicing isoforms for
TRPC3

Expression for TRPC3 Gene

mRNA expression in normal human tissues for TRPC3 Gene

mRNA differential expression in normal tissues according to GTEx for TRPC3 Gene

This gene is overexpressed in Pituitary (8.5), Brain - Putamen (basal ganglia) (6.0), Brain - Caudate (basal ganglia) (4.4), and Brain - Cerebellum (4.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TRPC3 Gene

SOURCE GeneReport for Unigene cluster for TRPC3 Gene Hs.150981

mRNA Expression by UniProt/SwissProt for TRPC3 Gene

Q13507-TRPC3_HUMAN
Tissue specificity: Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis
genes like me logo Genes that share expressions with TRPC3: view

Orthologs for TRPC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRPC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRPC3 36
  • 99.64 (n)
  • 99.78 (a)
TRPC3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRPC3 36
  • 92.72 (n)
  • 98.1 (a)
TRPC3 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRPC3 36
  • 93.52 (n)
  • 97.83 (a)
TRPC3 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trpc3 36
  • 87.14 (n)
  • 94.4 (a)
Trpc3 16
Trpc3 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRPC3 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRPC3 37
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trpc3 36
  • 87.86 (n)
  • 96.51 (a)
chicken
(Gallus gallus)
Aves TRPC3 36
  • 81.84 (n)
  • 93.03 (a)
TRPC3 37
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRPC3 37
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trpc3 36
  • 76.78 (n)
  • 90.22 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5785 36
zebrafish
(Danio rerio)
Actinopterygii TRPC3 37
  • 83 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea trp-1 38
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 45 (a)
OneToMany
Species with no ortholog for TRPC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRPC3 Gene

ENSEMBL:
Gene Tree for TRPC3 (if available)
TreeFam:
Gene Tree for TRPC3 (if available)

Paralogs for TRPC3 Gene

Paralogs for TRPC3 Gene

Selected SIMAP similar genes for TRPC3 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for TRPC3 Gene

genes like me logo Genes that share paralogs with TRPC3: view

Variants for TRPC3 Gene

Sequence variations from dbSNP and Humsavar for TRPC3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs884701 -- 121,909,251(-) ACTTC(C/T)GCTCC intron-variant
rs906493 -- 121,884,466(+) CATTA(C/T)ACATA intron-variant
rs906494 -- 121,912,246(-) CTAAA(A/G)AAGAA intron-variant
rs906495 -- 121,912,224(-) ATATA(A/G)AGCTT intron-variant
rs906496 -- 121,912,159(-) CCTAT(A/G)TTGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRPC3 Gene

Variant ID Type Subtype PubMed ID
esv24000 CNV Loss 19812545

Relevant External Links for TRPC3 Gene

HapMap Linkage Disequilibrium report
TRPC3
Human Gene Mutation Database (HGMD)
TRPC3

Disorders for TRPC3 Gene

(1) MalaCards Diseases for TRPC3 Gene

Search for TRPC3 Gene in MalaCards »

(2) Novoseek inferred disease relationships for TRPC3 Gene

Disease -log(P) Hits PubMed IDs
airways disease 21.3 1
essential hypertension 14.7 5

Relevant External Links for TRPC3

Genetic Association Database (GAD)
TRPC3
Human Genome Epidemiology (HuGE) Navigator
TRPC3
genes like me logo Genes that share disorders with TRPC3: view

No data available for UniProtKB/Swiss-Prot for TRPC3 Gene

Publications for TRPC3 Gene

  1. Receptor-activated Ca2+ influx via human Trp3 stably expressed in human embryonic kidney (HEK)293 cells. Evidence for a non-capacitative Ca2+ entry. (PMID: 9417057) Zhu X. … Birnbaumer L. (J. Biol. Chem. 1998) 3 4 23
  2. The TRPC3 channel has a large internal chamber surrounded by signal sensing antennas. (PMID: 17258231) Mio K. … Sato C. (J. Mol. Biol. 2007) 3 4 23
  3. trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. (PMID: 8646775) Zhu X. … Birnbaumer L. (Cell 1996) 2 3 4
  4. Coassembly of TRP and TRPL produces a distinct store-operated conductance. (PMID: 9215637) Xu X.-Z.S. … Montell C. (Cell 1997) 3 4
  5. The membrane topology of human transient receptor potential 3 as inferred from glycosylation-scanning mutagenesis and epitope immunocytochemistry. (PMID: 9535843) Vannier B. … Birnbaumer L. (J. Biol. Chem. 1998) 3 4

Products for TRPC3 Gene

  • Addgene plasmids for TRPC3

Sources for TRPC3 Gene

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