TRPC3 Gene
protein-coding GIFtS: 64
GCID: GC04M122800
|
|
transient receptor potential cation channel, subfamily C,...
| |
Aliases
for TRPC3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transient Receptor Potential Cation Channel, Subfamily C, Member 31 2 | | Short Transient Receptor Potential Channel 32 | | Transient Receptor Protein 32 3 | | TRP-33 | | TRP32 3 | | TrpC33 | | HTrp-31 | | HTrp31 |
Export aliases for TRPC3 gene to outside databasesPrevious GC identifers: GC04M123725 GC04M123079 GC04M123193 GC04M123259 GC04M123158 GC04M118526 |
Summaries
for TRPC3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TRPC3:
The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium andother cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activatedphosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcriptvariants encoding different isoforms have been found for this gene. (provided by RefSeq, Oct 2011)
UniProtKB/Swiss-Prot: TRPC3_HUMAN, Q13507Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by aphosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors.Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion
Gene Wiki entry for TRPC3
|
Genomic Views
for TRPC3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TRPC3 gene promoter:
CREB AML1a deltaCREB
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRPC3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRPC3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q27 Ensembl cytogenetic band: 4q27 HGNC cytogenetic band: 4q27TRPC3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M122800: view genomic region
(about GC identifiers)
Start:
|
122,800,182 bp from pter |
End:
|
122,872,909 bp from pter |
Size:
|
72,728 bases |
Orientation:
|
minus strand |
|
Proteins
for TRPC3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TRPC3_HUMAN, Q13507 (See
protein sequence)Recommended Name: Short transient receptor potential channel 3 Size: 836 amino acids; 96009 Da
Subunit: Interacts with TRPC1, ITPR1, ITPR3, MX1 and RNF24. Interacts with JPH2; the interaction is involved inmaintaining Ca(2+) homeostasis in skeletal muscle and is mediated by JPH2 'Ser-165' phosphorylation
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: A7VJS1 E9PCJ9 O00593 Q15660 Q52M35 Q5G1L5Alternative splicing: 3 isoforms: Q13507-1 Q13507-2 Q13507-3 Explore the universe of human proteins at neXtProt for TRPC3: NX_Q13507
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13507
TRPC3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001124170.1 NP_003296.1
ENSEMBL proteins: ENSP00000264811 ENSP00000368966 ENSP00000423866 ENSP00000426899 ENSP00000422214 Reactome Protein details: Q13507
Human Recombinant Protein Products for TRPC3:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TRPC3 for ontologies About GeneDecksing
TRPC3 Antibody Products:
Assay Products for TRPC3: |
Protein
Domains /
Families
for TRPC3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRPC3 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q13507ProtoNet protein and cluster: Q13507 4 Blocks protein families: IPB002110 Ankyrin repeat signature IPB002153 Transient receptor potential family signature IPB005459 Transient receptor potential channel 3 signature IPB013555 Transient receptor ion channel II
UniProtKB/Swiss-Prot: TRPC3_HUMAN, Q13507Similarity: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC3 sub-subfamilySimilarity: Contains 4 ANK repeats |
Function
for TRPC3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: TRPC3_HUMAN, Q13507Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by aphosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors.Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
TRPC3 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for TRPC3:
13 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Trpc3):
TRPC3 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for TRPC3: Trpc3tm1.1Bmil Trpc3tm1.1Akon
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRPC3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRPC3 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TRPC3 (NM_003305) | |  | Sino Biological Human cDNA Clone for TRPC3 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRPC3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPC3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC3 |
|
Pathways & Interactions
for TRPC3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by GPCR | | | 2 | Transcription_Role of VDR in regulation of genes involved in osteoporosis | | | 3 | Platelet activation, signaling and aggregation | | | 4 | Role of second messengers in netrin-1 signaling | | | 5 | G alpha (q) signalling events | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 EMD Millipore Pathways for TRPC3
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TRPC3
1  GeneGo (Thomson Reuters) Pathway for TRPC3
1  BioSystems Pathway for TRPC3
5/16 
Reactome Pathways for TRPC3 (see all 16)
TRPC3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRPC3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 23)
5/28 Interacting proteins for TRPC3 (Q135071, 3 ENSP000003689664) via UniProtKB, MINT, STRING, and/or I2D (see all 28)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
TRPC3 for ontologies About GeneDecksing
|
Drugs & Compounds
for TRPC3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TRPC3 for compounds About GeneDecksing
 Browse Tocris compounds for TRPC3
10/844 HMDB Compounds for TRPC3 (see all 844) About this table
10/19 Novoseek chemical compound relationships for TRPC3 gene (see all 19) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| 2-aminoethoxydiphenylborane |
87.7 |
2 |
20068131 (1), 17351372 (1) |
| 1-oleoyl-2-acetyl-sn-glycerol |
83.5 |
12 |
17351372 (3), 10882720 (2), 15533987 (2), 16522635 (2) (see all 5) |
| skf 96365 |
83.3 |
1 |
15972814 (1) |
| inositol 1,4,5 trisphosphate |
77.3 |
15 |
12606542 (4), 11553786 (2), 12730194 (2), 11248050 (2) (see all 8) |
| thapsigargin |
74.1 |
9 |
11042129 (1), 9417057 (1), 11600493 (1), 12736151 (1) (see all 8) |
| calcium |
65.5 |
68 |
9298988 (7), 18431718 (5), 17569672 (3), 12736256 (3) (see all 28) |
| 2-amino-4-phosphonobutyric acid |
64.8 |
1 |
15933213 (1) |
| kt 5823 |
52.5 |
2 |
14983059 (1), 16331690 (1) |
| calmidazolium |
48.2 |
4 |
11248050 (1) |
| carbachol |
44.5 |
12 |
18755685 (3), 11830588 (2), 19332491 (1), 14736881 (1) (see all 5) |
Search CenterWatch for drugs/clinical trials and news about TRPC3
|
Transcripts
for TRPC3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TRPC3 gene (2 alternative transcripts): NM_001130698.1 NM_003305.2 Unigene Cluster for TRPC3: Transient receptor potential cation channel, subfamily C, member 3 Hs.150981 [show with all ESTs]Unigene Representative Sequence: AY8655745 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000264811(uc003ief.2 uc011cgl.1) ENST00000379645(uc010inr.2 uc003ieg.2)
ENST00000506449 ENST00000513531 ENST00000502968
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRPC3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRPC3 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TRPC3 (NM_003305) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRPC3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPC3 |
Additional cDNA sequence: AB255423.1 AB255424.1 AY865574.1 BC093682.1 BC093684.1 BC143239.1 X89068.1 Y13758.1 3 DOTS entries: DT.409154 DT.100744119 DT.121225219 17 AceView cDNA sequences: AW207876 AW296897 AW014163 BX281448 NM_003305 AI655379 R34716 X89068 BF438538 Y13758 BF516575 U47050 AI088264 BF512869 AA248593 D61017 R49588
GeneLoc Exon Structure
|
Expression
for TRPC3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRPC3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAATGCATT
About this image
See TRPC3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRPC3
SOURCE GeneReport for Unigene cluster: Hs.150981
UniProtKB/Swiss-Prot: TRPC3_HUMAN, Q13507Tissue specificity: Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung,prostate, placenta and testis
SABiosciences Expression via Pathway-Focused PCR Array including TRPC3:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRPC3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRPC3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRPC3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRPC3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC3 |
Orthologs
for TRPC3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TRPC3 gene from 4/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TRPC31 |
transient receptor potential cation channel, subfamily more |
82.14(n)
93.68(a) |
|
374153 XM_003641203.1 XP_003641251.1 |
lizard
(Anolis carolinensis) |
Reptilia |
TRPC36 |
-- |
93(a) |
1 ↔ 1 |
5(138950276-139006843) |
rainbow trout
(Oncorhynchus mykiss) |
Actinopterygii |
Omy.57852 |
Oncorhynchus mykiss transcribed sequence with moderate more |
83.23(n) |
|
BX317063.1 |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
28(a) |
1 → many |
GroupUn.1268(2616-22451) |
ENSEMBL Gene Tree for TRPC3 (if available)
TreeFam Gene Tree for TRPC3 (if available) |
Paralogs
for TRPC3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TRPC3 gene
- TRPC42 TRPC12 TRPC62 TRPC72 TRPC52
6 SIMAP similar genes for TRPC3 using alignment to 6 protein entries: TRPC3_HUMAN (see all proteins):TRPC7 TRP7 TRPC6 TRPC4 TRPC5 TRPC1
TRPC3 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TRPC3
PGOHUM00000250393
|
Genomic Variants
for TRPC3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 4 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TRPC3 (122800182 - 122872909 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TRPC3
1 Indel: 68791
Human Gene Mutation Database (HGMD): TRPC3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRPC3 |
|
Disorders
/ Diseases
for TRPC3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TRPC3 for disorders About GeneDecksing
OMIM gene information: 602345
OMIM disorders: --
20/22  diseases for TRPC3 (see all 22): About MalaCardslambert-eaton myasthenic syndrome type 2 diabetes mellitus myasthenia gravis essential hypertension
diabetes mellitus myasthenic syndrome myasthenia malignant hypertension
bipolar disorder hypertension kidney disease osteoporosis
ovarian cancer astrocytoma prostate cancer breast cancer
cerebritis cholesterol hypoxia prostatitis
1 disease from the University of Copenhagen DISEASES database for TRPC3:Scheuermann's disease 2 Novoseek disease relationships for TRPC3 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| airways disease |
21.3 |
1 |
16574942 (1) |
| essential hypertension |
14.7 |
5 |
17351372 (3), 18177730 (2) |
Human Genome Epidemiology (HuGE) Navigator: TRPC3 (1 document)
Export disorders for TRPC3 gene to outside databases
|
Publications
for TRPC3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRPC3 gene, integrated from 9 sources (see all 169):
(articles sorted by number of sources associating them with TRPC3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. (PubMed id 8646775)1, 2, 3 Zhu X....Birnbaumer L. (1996)
- Receptor-activated Ca2+ influx via human Trp3 stably expressed in human embryonic kidney (HEK)293 cells. Evidence for a non-capacitative Ca2+ entry. (PubMed id 9417057)1, 2, 9 Zhu X.... Birnbaumer L. (1998)
- Molecular cloning of TRPC3a, an N-terminally extended, store-operated variant of the human C3 transient receptor potential channel. (PubMed id 15728370)1, 2 Yildirim E.... Birnbaumer L. (2005)
- MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC. (PubMed id 15757897)1, 2 Lussier M.P....Boulay G. (2005)
- International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. (PubMed id 16382100)1, 3 Clapham D.E....Schultz G. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Modulation of Ca(2+) entry by polypeptides of the inositol 1,4, 5- trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca(2+) entry. (PubMed id 10611319)1, 2 Boulay G.... Birnbaumer L. (1999)
- Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. (PubMed id 9930701)1, 2 Hofmann T....Schultz G. (1999)
- The membrane topology of human transient receptor potential 3 as inferred from glycosylation-scanning mutagenesis and epitope immunocytochemistry. (PubMed id 9535843)1, 2 Vannier B.... Birnbaumer L. (1998)
- Functional interaction between InsP3 receptors and store-operated Htrp3 channels. (PubMed id 9853757)1, 2 Kiselyov K.... Muallem S. (1998)
|
External Searches for TRPC3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TRPC3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRPC3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TRPC3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TRPC3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TRPC3 gene:
Search GeneIP for patents involving TRPC3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TRPC3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
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| | |  | OriGene Antibodies for TRPC3 | | OriGene shRNA RFP for TRPC3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRPC3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRPC3 | | | OriGene Protein Over-expression Lysate for TRPC3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TRPC3 | | OriGene 3'-UTR Clone for TRPC3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRPC3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRPC3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TRPC3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TRPC3 | | OriGene Custom Protein Services for TRPC3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRPC3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRPC3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRPC3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRPC3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRPC3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRPC3 |
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| | | | Search Tocris compounds for TRPC3 |
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 | | | TRPC3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC3 |
|  |  |  |  | | | | ThermoFisher Antibodies for TRPC3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPC3 |
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