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Aliases for TRPC2 Gene

Aliases for TRPC2 Gene

  • Transient Receptor Potential Cation Channel, Subfamily C, Member 2, Pseudogene 2 3
  • Transient Receptor Potential Cation Channel, Subfamily C, Member 2 2

External Ids for TRPC2 Gene

Previous GeneCards Identifiers for TRPC2 Gene

  • GC11P004223
  • GC11U900038
  • GC11P003607
  • GC11P003601
  • GC11P003611
  • GC11P003385

Summaries for TRPC2 Gene

GeneCards Summary for TRPC2 Gene

TRPC2 (Transient Receptor Potential Cation Channel, Subfamily C, Member 2, Pseudogene) is a Pseudogene. Among its related pathways are CREB Pathway.

Gene Wiki entry for TRPC2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRPC2 Gene

Genomics for TRPC2 Gene

Regulatory Elements for TRPC2 Gene

Genomic Location for TRPC2 Gene

Start:
3,609,901 bp from pter
End:
3,637,559 bp from pter
Size:
27,659 bases
Orientation:
Plus strand

Genomic View for TRPC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRPC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRPC2 Gene

Proteins for TRPC2 Gene

Post-translational modifications for TRPC2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TRPC2 Gene

Domains for TRPC2 Gene

Gene Families for TRPC2 Gene

HGNC:
  • TRP :Voltage-gated ion channels / Transient receptor potential cation channels
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRPC2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TRPC2 Gene

Function for TRPC2 Gene

Molecular function for TRPC2 Gene

GENATLAS Biochemistry: transient receptor potential non voltage-channel 2,Drosophila store-operated channel (Soc) homolog,ubiquitous predominantly expressed in fetal brain,adult heart,brain,testis,ovaries,activated by calcium store depletion, component of the capacitative calcium entry,channels (homo or heterotetramer),may be a pseudogene
genes like me logo Genes that share phenotypes with TRPC2: view

Animal Models for TRPC2 Gene

MGI Knock Outs for TRPC2:

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targeting and HOMER Transcription for TRPC2 Gene

Localization for TRPC2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TRPC2 Gene

Pathways for TRPC2 Gene

SuperPathways for TRPC2 Gene

Superpath Contained pathways
1 CREB Pathway
genes like me logo Genes that share pathways with TRPC2: view

Pathways by source for TRPC2 Gene

1 Qiagen pathway for TRPC2 Gene

Interacting Proteins for TRPC2 Gene

Gene Ontology (GO) - Biological Process for TRPC2 Gene

None

Transcripts for TRPC2 Gene

mRNA/cDNA for TRPC2 Gene

(8) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TRPC2 Gene

No ASD Table

Relevant External Links for TRPC2 Gene

GeneLoc Exon Structure for
TRPC2
ECgene alternative splicing isoforms for
TRPC2

Expression for TRPC2 Gene

mRNA expression in normal human tissues for TRPC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRPC2 Gene

This gene is overexpressed in Spleen (4.1) and Whole Blood (4.1).

SOURCE GeneReport for Unigene cluster for TRPC2 Gene Hs.131910

genes like me logo Genes that share expressions with TRPC2: view

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for TRPC2 Gene

Orthologs for TRPC2 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for TRPC2 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Trpc2 16
Species with no ortholog for TRPC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRPC2 Gene

ENSEMBL:
Gene Tree for TRPC2 (if available)
TreeFam:
Gene Tree for TRPC2 (if available)

Paralogs for TRPC2 Gene

No data available for Paralogs for TRPC2 Gene

Variants for TRPC2 Gene

Sequence variations from dbSNP and Humsavar for TRPC2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs925698 -- 3,636,195(+) CTACA(C/T)AGAGA nc-transcript-variant
rs1055470 -- 3,637,373(+) GGATT(C/G)TGAGG nc-transcript-variant
rs1473937 -- 3,627,015(-) AGAAA(A/C)ATATA intron-variant
rs1473938 -- 3,634,516(+) CAGGG(A/C)CAAGA intron-variant
rs1514689 -- 3,635,736(+) TGACA(A/G)TGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRPC2 Gene

Variant ID Type Subtype PubMed ID
dgv336e1 CNV Complex 17122850
esv28322 CNV Gain+Loss 19812545
nsv832051 CNV Gain 17160897
essv2992 CNV CNV 17122850
nsv467660 CNV Gain 19166990
dgv337e1 CNV Complex 17122850
nsv428247 CNV Loss 18775914
nsv832052 CNV Loss 17160897
nsv526441 CNV Gain 19592680
nsv896892 CNV Gain 21882294
esv2662660 CNV Deletion 23128226
dgv186e199 CNV Deletion 23128226
esv2675176 CNV Deletion 23128226
esv2744037 CNV Deletion 23290073
nsv825717 CNV Loss 20364138
esv2678063 CNV Deletion 23128226
esv2658889 CNV Deletion 23128226
nsv509385 CNV Insertion 20534489

Relevant External Links for TRPC2 Gene

HapMap Linkage Disequilibrium report
TRPC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRPC2 Gene

Disorders for TRPC2 Gene

No disorders were found for TRPC2 Gene.

No data available for UniProtKB/Swiss-Prot for TRPC2 Gene

Publications for TRPC2 Gene

  1. TRPC1, a human homolog of a Drosophila store-operated channel. (PMID: 7568191) Wes P.D. … Montell C. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3
  2. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. (PMID: 16382100) Clapham D.E. … Schultz G. (Pharmacol. Rev. 2005) 2 3
  3. TRPC2: molecular biology and functional importance. (PMID: 17217050) Yildirim E. … Birnbaumer L. (Handb Exp Pharmacol 2007) 2 3
  4. Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates. (PMID: 20210993) Zhang Z.D. … Gerstein M. (Genome Biol. 2010) 3
  5. TRPC2. (PMID: 24756702) Miller B.A. (Handb Exp Pharmacol 2014) 3

Products for TRPC2 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate TRPC2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TRPC2
    • Block miRNA regulation of TRPC2 using miScript Target Protectors

    Sources for TRPC2 Gene

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