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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TRPC2 Gene

pseudogene GIFtS: 33
GCID: GC11P003604

transient receptor potential cation channel, subfamily C,...

(Previous names: transient receptor potential cation channel, subfamily...)

Search for TRPC2
in

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our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 5

Aliases
Transient Receptor Potential Cation Channel, Subfamily C, Member 2, Pseudogene¹ ²
Transient Receptor Potential Cation Channel, Subfamily C, Member 2¹

External Ids:	HGNC: 12334¹	Entrez Gene: 7221²	Ensembl: ENSG00000182048⁷

ORGUL members:	fRNAdb¹⁰:FR368334
	NCBI:XR_000147
	NONCODE:n381598 n381599
	RNAdb:LIT2049

Export aliases for TRPC2 gene to outside databases

Previous GC identifers: GC11P004223 GC11U900038 GC11P003607 GC11P003601 GC11P003611 GC11P003385

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for TRPC2

fRNAdb sequence ontology for TRPC2:
mature_transcript - A transcript which has undergone the necessary modifications, if any, for its function. In eukaryotes this includes, for example, processing of introns, cleavage, base modification, and modifications to the 5' and/or the 3' ends, other than addition of bases. In bacteria functional mRNAs are usually not modified.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TRPC2 gene promoter:
c-Fos AhR ER-alpha ISGF-3 AP-1 JunB Fra-1 FosB JunD c-Jun
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for TRPC2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRPC2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4-p15.3 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.4-p15.3

TRPC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRPC2 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P003604: view genomic region (about GC identifiers)

Start:	3,631,131 bp from pter	End:	3,658,789 bp from pter
Size:	27,659 bases	Orientation:	plus strand

ORGUL member locations:
Legend (see complete legend)

FR0368334
n381598
n381599

lncRNA
Full Legend

3637038 3647914 3658789 chr11

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB: --

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

Genatlas biochemistry entry for TRPC2:

transient receptor potential non voltage-channel 2,Drosophila store-operated channel (Soc) homolog,ubiquitous

predominantly expressed in fetal brain,adult heart,brain,testis,ovaries,activated by calcium store depletion,

component of the capacitative calcium entry,channels (homo or heterotetramer),may be a pseudogene

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Animal Models:
Mouse knock-outs for TRPC2: Trpc2^tm1Dlc Trpc2^tm1Rax
6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Trpc2):

behavior/neurological	craniofacial	hematopoietic system	homeostasis/metabolism	nervous system
respiratory system

TRPC2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Calcium channels

Calcium channels

1.00

CREB Pathway

Intracellular Calcium Signaling

0.50

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for TRPC2

Calcium channels

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TRPC2

Intracellular Calcium Signaling

TRPC2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TRPC2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

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Search CenterWatch for drugs/clinical trials and news about TRPC2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

Unigene Clusters for TRPC2:

Transient receptor potential cation channel, subfamily C, member 2, pseudogene

Hs.131910 [show with all ESTs], Hs.690732

Unigene Representative Sequences: NR_002720, AB231779

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000451043 ENST00000526541(uc001lya.1) ENST00000399582(uc001lxz.1)

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Additional cDNA sequence: AB231779.1

3 DOTS entries:

DT.208208 DT.92047203 DT.120678536

8 AceView cDNA sequences:

X89067 BX097810 AI769824 AI016598 AA423920 H61599 AA423856 AI313316

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRPC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTTGTGTCA

About this image
Genevestigator expression for TRPC2

SOURCE GeneReport for Unigene clusters: Hs.131910 Hs.690732

SABiosciences Custom PCR Arrays for TRPC2

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for TRPC2 gene from 1 species (see representative species ) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Trpc2⁵	transient receptor potential cation channel, subfamily more	--		7 (54.71 cM) 102065511

ENSEMBL Gene Tree for TRPC2 (if available)
TreeFam Gene Tree for TRPC2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111550408^1,2		--	3645738(+)	`TACCCG/ATGGGA`	1	--	us2k¹		1		CSA	2
rs117139335^1,2	F,	--	3645791(+)	`CATGTA/GATAAA`	1	--	us2k¹		1		EA	120
rs60847407^1,2	C,F,	--	3645895(+)	`CACCCT/CACCCT`	1	--	us2k¹		5		WA CSA NA EA	362
rs148061759^1,2		--	3645941(+)	`TTCCCA/GACCAC`	1	--	us2k¹		0	--	--	--	--
rs58014283^1,2	C,F,	--	3646003(+)	`TTGCCT/CCTTCC`	1	--	us2k¹		5		WA CSA NA EA	362
rs111451629^1,2		--	3646044(+)	`CTCCTC/TCTTCA`	1	--	us2k¹		1		CSA	2
rs7115278^1,2	C,F,H,	--	3646116(+)	`TCCATC/TCCTAA`	1	--	us2k¹		12		NS EA NA WA CSA	784
rs7115284^1,2	C,F,H,	--	3646127(+)	`ACACCC/TATAAC`	1	--	us2k¹		12		NS EA NA WA CSA	784
rs7103680^1,2	C,F,H,	--	3646181(+)	`TTGTGT/GGAGAC`	1	--	us2k¹		11		NS EA NA WA CSA	666
rs150587248^1,2		--	3646201(+)	`TTACCC/TACTAT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TRPC2 (3631131 - 3658789 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TRPC2
2 CNVs: 3833 71243

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TRPC2 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with TRPC2)

Utopia: connect your pdf to the dynamic
world of online information

TRPC2: molecular biology and functional importance. (PubMed id 17217050)^{1, 3} Yildirim E. and Birnbaumer L. (2007)
International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. (PubMed id 16382100)^{1, 3} Clapham D.E....Schultz G. (2005)
TRPC1, a human homolog of a Drosophila store-operated channel. (PubMed id 7568191)^{1, 3} Wes P.D....Montell C. (1995)
Identification and analysis of unitary pseudogenes: h istoric and contemporary gene losses in humans and other primates. (PubMed id 20210993)¹ Zhang Z.D....Gerstein M. (2010)
Interaction of TRPC2 and TRPC6 in erythropoietin modulation of calcium influx. (PubMed id 14699131)¹ Chu X....Miller B.A. (2004)
Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. (PubMed id 14505576)¹ Yuan J.P....Worley P.F. (2003)
The mouse C-type transient receptor potential 2 (TRPC2) channel: alternative splicing and calmodulin binding to its N terminus. (PubMed id 12601176)¹ Yildirim E....Birnbaumer L. (2003)
Relaxed selective pressure on an essential component of pheromone transduction in primate evolution. (PubMed id 12631698)¹ Liman E.R. and Innan H. (2003)
Subunit composition of mammalian transient receptor potential channels in living cells. (PubMed id 12032305)¹ Hofmann T.... Gudermann T. (2002)
Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels. (PubMed id 11290752)¹ Tang J....Zhu M.X. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7221	HGNC: 12334	AceView: TRPC2	Ensembl:ENSG00000182048	euGenes: HUgn7221
ECgene: TRPC2	H-InvDB: TRPC2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TRPC2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TRPC2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TRPC2 gene:
Search GeneIP for patents involving TRPC2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Aliases
for TRPC2 gene

Summaries
for TRPC2 gene

Genomic Views
for TRPC2 gene

Proteins
for TRPC2 gene

Protein Domains /
Families
for TRPC2 gene

Function
for TRPC2 gene

Pathways & Interactions
for TRPC2 gene

Drugs & Compounds
for TRPC2 gene

Transcripts
for TRPC2 gene

Expression
for TRPC2 gene

Orthologs
for TRPC2 gene

Paralogs
for TRPC2 gene

Genomic Variants
for TRPC2 gene

Disorders / Diseases
for TRPC2 gene

Publications
for TRPC2 gene

Intellectual Property
for TRPC2 gene

Products
for TRPC2 gene