Aliases for TRPC1 Gene
External Ids for TRPC1 Gene
Previous GeneCards Identifiers for TRPC1 Gene
The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for TRPC1 Gene
TRPC1 (Transient Receptor Potential Cation Channel, Subfamily C, Member 1) is a Protein Coding gene. Among its related pathways are Downstream Signaling Events Of B Cell Receptor (BCR) and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ion channel binding and store-operated calcium channel activity. An important paralog of this gene is TRPC6.
UniProtKB/Swiss-Prot for TRPC1 Gene
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.