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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRPC1 Gene

protein-coding   GIFtS: 61
GCID: GC03P142440

Transient Receptor Potential Cation Channel, Subfamily C,...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transient Receptor Potential Cation Channel, Subfamily C, Member 11 2     HTRP-12
TRP12 3 5     Short Transient Receptor Potential Channel 12
Transient Receptor Protein 12 3     Transient Receptor Potential Canonical 12
TRP-12 3     TrpC13

External Ids:    HGNC: 123331   Entrez Gene: 72202   Ensembl: ENSG000001449357   OMIM: 6023435   UniProtKB: P489953   

Export aliases for TRPC1 gene to outside databases

Previous GC identifers: GC03P139404 GC03P143271 GC03P143724 GC03P143764 GC03P143925 GC03P139815


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRPC1 Gene:
The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium
and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine
kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium
stores. Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq,
Oct 2011)

GeneCards Summary for TRPC1 Gene: 
TRPC1 (transient receptor potential cation channel, subfamily C, member 1) is a protein-coding gene. Diseases associated with TRPC1 include hypertrophic pyloric stenosis, and pyloric stenosis, and among its related super-pathways are Axon guidance and Immune System. GO annotations related to this gene include store-operated calcium channel activity and ion channel binding. An important paralog of this gene is TRPC4.

UniProtKB/Swiss-Prot: TRPC1_HUMAN, P48995
Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated
by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled
receptors. Seems to be also activated by intracellular calcium store depletion

Gene Wiki entry for TRPC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRPC1 gene promoter:
         AP-2rep   HOXA9   HOXA9B   CUTL1   Meis-1b   Evi-1   C/EBPalpha   CHOP-10   FOXO4   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRPC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRPC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRPC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q23   Ensembl cytogenetic band:  3q23   HGNC cytogenetic band: 3q23

TRPC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRPC1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P142440:  view genomic region     (about GC identifiers)

Start:
142,442,916 bp from pter      End:
142,526,730 bp from pter
Size:
83,815 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRPC1_HUMAN, P48995 (See protein sequence)
Recommended Name: Short transient receptor potential channel 1  
Size: 793 amino acids; 91212 Da
Subunit: Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC4 and/or TRPC5.
Interacts with TRPC3, TRPC4 and TRPC5. Interacts with ITPR3. Interacts with MX1 and RNF24. Interacts with FKBP4
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q14CE4
Alternative splicing: 2 isoforms:  P48995-1   P48995-2   

Explore the universe of human proteins at neXtProt for TRPC1: NX_P48995

Explore proteomics data for TRPC1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P48995

  • TRPC1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRPC1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001238774.1  NP_003295.1  

    ENSEMBL proteins: 
     ENSP00000419313   ENSP00000273482   ENSP00000418708  
    Reactome Protein details: P48995
    Human Recombinant Protein Products for TRPC1: 
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    Cloud-Clone Corp. Proteins for TRPC1 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS7568191
    GO:0016020membrane ----
    GO:0016021integral to membrane ----

    TRPC1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TRP: Voltage-gated ion channels / Transient receptor potential cation channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: TRPC1 
    Transient Receptor Potential channels

    5/7 InterPro protein domains (see all 7):
     IPR002153 TRPC_channel
     IPR005457 TRPC1_channel
     IPR020683 Ankyrin_rpt-contain_dom
     IPR005821 Ion_trans_dom
     IPR004729 TRP_channel

    Graphical View of Domain Structure for InterPro Entry P48995

    ProtoNet protein and cluster: P48995

    3 Blocks protein domains:
    IPB002153 Transient receptor potential family signature
    IPB005457 Transient receptor potential channel 1 signature
    IPB013555 Transient receptor ion channel II


    UniProtKB/Swiss-Prot: TRPC1_HUMAN, P48995
    Similarity: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily
    Similarity: Contains 4 ANK repeats


    TRPC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRPC1_HUMAN, P48995
    Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated
    by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled
    receptors. Seems to be also activated by intracellular calcium store depletion

         Genatlas biochemistry entry for TRPC1:
    transient receptor potential non voltage-channel 1,Drosophila store-operated channel (Soc) homolog,ubiquitous but
    predominantly expressed in fetal brain,adult heart,brain,testis,ovaries,activated by calcium store depletion
    component of the capacitative calcium entry channels (homo or heterotetramer)

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005261cation channel activity EXP--
    GO:0005262calcium channel activity TAS8646775
    GO:0005515protein binding IPI14505576
    GO:0015279store-operated calcium channel activity IEA--
         
    TRPC1 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Trpc1):
     behavior/neurological  cardiovascular system  digestive/alimentary  endocrine/exocrine gland  growth/size 
     nervous system 

    TRPC1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Trpc1tm1Lbi for TRPC1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRPC1 
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    SwitchGear 3'UTR luciferase reporter plasmidTRPC1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TRPC1 About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Axon guidance
    Axon guidance0.69
    Developmental Biology0.69
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56
    3Circadian entrainment
    Glutamatergic synapse0.39
    Serotonergic synapse0.33
    4Development Ligand-independent activation of ESR1 and ESR2
    Transcription CREB pathway0.93
    5Signaling by the B Cell Receptor (BCR)
    Signaling by the B Cell Receptor (BCR)0.81

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for TRPC1
        Transcription CREB pathway
    Calcium channels

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TRPC1
        Intracellular Calcium Signaling

    5/8        Reactome Pathways for TRPC1 (see all 8)
        Developmental Biology
    Adaptive Immune System
    Signaling by the B Cell Receptor (BCR)
    Netrin-1 signaling
    Antigen Activates B Cell Receptor Leading to Generation of Second Messengers


    3         Kegg Pathways  (Kegg details for TRPC1):
        Glutamatergic synapse
    Serotonergic synapse
    Pancreatic secretion


    TRPC1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRPC1

    5/18 Interacting proteins for TRPC1 (P489953) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MX1P205913I2D: score=3 
    BMPR2Q138733I2D: score=2 
    CAV1Q031353I2D: score=2 
    HOMER1Q86YM73I2D: score=2 
    ITPR3Q145733I2D: score=2 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0006816calcium ion transport TAS8646775
    GO:0007411axon guidance TAS--
    GO:0046541saliva secretion IEA--
    GO:0051281positive regulation of release of sequestered calcium ion into cytosol IDA19052258

    TRPC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRPC1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for TRPC1

    1 HMDB Compound for TRPC1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    5 IUPHAR Ligands for TRPC1 (TRPC1)    About this table 
    LigandTypeActionAffinityPubmed IDs
    SKF96365
    Channel blockerNone--
    GsMTx-4
    Channel blockerNone--
    La3+
    Pore BlockerAntagonist11301024
    Gd3+
    Pore BlockerAntagonist8663995
    2-APB
    Pore BlockerAntagonist11301024

    10/14 Novoseek inferred chemical compound relationships for TRPC1 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    skf 96365 84.9 3 20003325 (1), 15972814 (1), 17217049 (1)
    thapsigargin 77.3 16 16899508 (2), 12536150 (1), 12736151 (1), 17224452 (1) (see all 11)
    calcium 68 135 12766172 (6), 16551274 (5), 16283206 (4), 15920022 (4) (see all 50)
    inositol 1,4,5 trisphosphate 65.9 11 12766172 (2), 12161078 (1), 19052258 (1), 10970773 (1) (see all 9)
    capsazepine 50.1 1 16731017 (1)
    jasplakinolide 49.9 1 12196544 (1)
    lanthanum 32.4 3 15728185 (1)
    carbachol 29.9 2 19332491 (1), 15542611 (1)
    inositol 27.9 3 10970773 (1), 18289524 (1)
    ryanodine 27.8 1 11399258 (1)

    Search CenterWatch for drugs/clinical trials and news about TRPC1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRPC1 gene (2 alternative transcripts): 
    NM_001251845.1  NM_003304.4  

    Unigene Cluster for TRPC1:

    Transient receptor potential cation channel, subfamily C, member 1
    Hs.250687  [show with all ESTs]
    Unigene Representative Sequence: NM_001251845
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000476941(uc011bni.1) ENST00000273482(uc003evc.3 uc003evb.3)
    ENST00000460401 ENST00000480101

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    Additional mRNA sequence: 

    AB255425.1 BC112338.1 BC113953.1 EF522961.1 GQ293239.1 X89066.1 

    7 DOTS entries:

    DT.443697  DT.99955737  DT.99989787  DT.100831489  DT.92022360  DT.102824421  DT.95259962 

    24/60 AceView cDNA sequences (see all 60):

    BE218965 AA258316 AA242949 AW949452 Z41868 H84832 AI682471 T07204 
    AI301172 W30728 BQ003340 AI560821 AI683848 AU123453 AA242814 AI765417 
    AW274590 BX389360 NM_003304 H09740 AA258337 BI752497 BF476749 X89066 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRPC1 expression in normal human tissues (normalized intensities)      TRPC1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTGAGTTG
    TRPC1 Expression
    About this image


    TRPC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/37 selected tissues (see all 37) fully expand
     
     Uterus
             uterus, post-menopause ; glandular cells   
             endometrial endothelial cell   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   

    See TRPC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRPC1

    SOURCE GeneReport for Unigene cluster: Hs.250687

    UniProtKB/Swiss-Prot: TRPC1_HUMAN, P48995
    Tissue specificity: Seems to be ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Array including TRPC1: 
              Neuronal Ion Channels in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TRPC1 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trpc11 , 5 transient receptor potential cation channel, subfamily more1, 5 90.87(n)1
    99.74(a)1
      9 (50.20 cM)5
    220631  NM_011643.21  NP_035773.11 
     957066275 
    chicken
    (Gallus gallus)
    Aves TRPC11 transient receptor potential cation channel, subfamily more 83.53(n)
    93.57(a)
      424776  NM_001004409.1  NP_001004409.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRPC16
    Uncharacterized protein
    86(a)
    1 ↔ 1
    3(21735262-21760289)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.4702 Xenopus laevis cation channel TRP-1 (trp1) mRNA, complete more 78.54(n)    AF113508.1 
    zebrafish
    (Danio rerio)
    Actinopterygii trpc11 transient receptor potential cation channel, subfamily more 73.13(n)
    84.93(a)
      570841  NM_001198661.1  NP_001185590.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta trpgamma6
    trpl6
    (see all 3)
    trp-like
    (see all 3)
    28(a)
    24(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    2L(16664767-16676666)
    2R(5641202-5653023)
    worm
    (Caenorhabditis elegans)
    Secernentea trp-13 Transient-receptor-potential (trp)
    protein
    35(a)   III(8607645-8614376)   --


    ENSEMBL Gene Tree for TRPC1 (if available)
    TreeFam Gene Tree for TRPC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRPC1 gene
    TRPC42  TRPC72  TRPC62  TRPC52  TRPC32  
    4 SIMAP similar genes for TRPC1 using alignment to 3 protein entries:     TRPC1_HUMAN (see all proteins):
    TRPC5    TRPC4    TRP7    TRPC6

    TRPC1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1564 SNPs in TRPC1 are shown (see all 1564)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs616680401,2
    C--142418756(+) AACCTA/GGGAGG 2 -- us2k10--------
    rs1416012381,2
    C--142418940(+) TCCAAC/GTCAAA 2 -- us2k10--------
    rs1417023591,2
    C--142419300(+) CTGTG-/ATATAT
            
    ATATA
    2 -- us2k10--------
    rs1500820181,2
    --142419329(+) GTGGTA/GTATAT 2 -- us2k10--------
    rs1822217411,2
    --142419345(+) TGATAC/TATATA 2 -- us2k10--------
    rs1385434411,2
    --142419375(+) AGCCAC/TAAAAA 2 -- us2k10--------
    rs2005448331,2
    C--142419427(+) GAGAC-/TATTATTC 2 -- us2k10--------
    rs1415465861,2
    --142419539(+) ACACAA/GTGGAC 2 -- us2k10--------
    rs1854622471,2
    --142419632(+) GGGTAC/TATCAA 2 -- us2k10--------
    rs1462043611,2
    --142419819(+) ATGAGC/TACAAC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TRPC1 (142442916 - 142526730 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TRPC1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv274601CNV Insertion20981092
    esv268258CNV Insertion20981092
    nsv820119CNV Loss19587683
    dgv300n21CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602343    OMIM disorders: --

    20/21 diseases for TRPC1 (see all 21):    About MalaCards
    hypertrophic pyloric stenosis    pyloric stenosis    duchenne muscular dystrophy    polycystic kidney disease
    kidney disease    basal cell carcinoma    malignant glioma    muscular dystrophy
    gingivitis    bipolar disorder    ischemia    endotheliitis
    cerebritis    hypoxia    neuroblastoma    retinitis
    prostate cancer    prostatitis    pancreatitis    neuronitis


    TRPC1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    5 Novoseek inferred disease relationships for TRPC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 0 3 16551274 (1), 15347566 (1), 17085428 (1)
    inflammation 0 2 16709572 (1), 17023906 (1)
    tumors 0 2 15347566 (1), 17085428 (1)
    neurodegeneration 0 2 15678080 (1), 15542611 (1)
    cerebral ischemia 0 1 16444289 (1)

    Genetic Association Database (GAD): TRPC1
    Human Genome Epidemiology (HuGE) Navigator: TRPC1 (5 documents)

    Export disorders for TRPC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRPC1 gene, integrated from 9 sources (see all 214):
    (articles sorted by number of sources associating them with TRPC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TRPC1, a human homolog of a Drosophila store-operated channel. (PubMed id 7568191)1, 2, 3, 9 Wes P.D....Montell C. (1995)
    2. TrpC1 is a membrane-spanning subunit of store-operated Ca(2+) channels in native vascular smooth muscle cells. (PubMed id 11139478)1, 2, 9 Xu S.-Z. and Beech D.J. (2001)
    3. Assembly of Trp1 in a signaling complex associated with caveolin- scaffolding lipid raft domains. (PubMed id 10766822)1, 2, 9 Lockwich T.P....Ambudkar I.S. (2000)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. Infantile hypertrophic pyloric stenosis: evaluation o f three positional candidate genes, TRPC1, TRPC5 and TRPC6, by association anal ysis and re-sequencing. (PubMed id 19701773)1, 4 Everett K.V....Chung E.M. (2009)
    6. Peptidyl-prolyl isomerase FKBP52 controls chemotropic guidance of neuronal growth cones via regulation of TRPC1 channel opening. (PubMed id 19945390)1, 2 Shim S....Worley P.F. (2009)
    7. Evaluation of Genetic Association and Expression Reduction of TRPC1 in the Development of Diabetic Nephropathy. (PubMed id 18802326)1, 4 Zhang D....Gu H.F. (2008)
    8. MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC. (PubMed id 15757897)1, 2 Lussier M.P....Boulay G. (2005)
    9. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. (PubMed id 16382100)1, 3 Clapham D.E....Schultz G. (2005)
    10. Subunit composition of mammalian transient receptor potential channels in living cells. (PubMed id 12032305)1, 2 Hofmann T.... Gudermann T. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7220 HGNC: 12333 AceView: TRPC1 Ensembl:ENSG00000144935 euGenes: HUgn7220
    ECgene: TRPC1 Kegg: 7220 H-InvDB: TRPC1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRPC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRPC1 gene:
    Search GeneIP for patents involving TRPC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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