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Aliases for TRPC1 Gene

Aliases for TRPC1 Gene

  • Transient Receptor Potential Cation Channel Subfamily C Member 1 2 3 5
  • Transient Receptor Protein 1 3 4
  • TRP-1 3 4
  • TRP1 3 4
  • Transient Receptor Potential Cation Channel, Subfamily C, Member 1 2
  • Short Transient Receptor Potential Channel 1 3
  • Capacitative Calcium Channel Protein Trp1 3
  • Transient Receptor Potential Canonical 1 3
  • HTRP-1 3
  • TrpC1 4

External Ids for TRPC1 Gene

Previous GeneCards Identifiers for TRPC1 Gene

  • GC03P139404
  • GC03P143271
  • GC03P143724
  • GC03P143764
  • GC03P143925
  • GC03P142440
  • GC03P139815

Summaries for TRPC1 Gene

Entrez Gene Summary for TRPC1 Gene

  • The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for TRPC1 Gene

TRPC1 (Transient Receptor Potential Cation Channel Subfamily C Member 1) is a Protein Coding gene. Among its related pathways are Serotonergic synapse and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include ion channel activity and calcium channel activity. An important paralog of this gene is TRPC5.

UniProtKB/Swiss-Prot for TRPC1 Gene

  • Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

Gene Wiki entry for TRPC1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRPC1 Gene

Genomics for TRPC1 Gene

Regulatory Elements for TRPC1 Gene

Enhancers for TRPC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G142723 1 ENCODE 6.2 +0.5 477 2.2 PKNOX1 ATF1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 GLI4 ZNF2 TRPC1 RNF7 GC03M142746
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRPC1 on UCSC Golden Path with GeneCards custom track

Promoters for TRPC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000159448 569 2000 PKNOX1 ATF1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 GLI4 ZNF2

Genomic Location for TRPC1 Gene

Chromosome:
3
Start:
142,724,032 bp from pter
End:
142,807,888 bp from pter
Size:
83,857 bases
Orientation:
Plus strand

Genomic View for TRPC1 Gene

Genes around TRPC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRPC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRPC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRPC1 Gene

Proteins for TRPC1 Gene

  • Protein details for TRPC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48995-TRPC1_HUMAN
    Recommended name:
    Short transient receptor potential channel 1
    Protein Accession:
    P48995
    Secondary Accessions:
    • Q14CE4

    Protein attributes for TRPC1 Gene

    Size:
    793 amino acids
    Molecular mass:
    91212 Da
    Quaternary structure:
    • Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC4 and/or TRPC5. Interacts with TRPC3, TRPC4 and TRPC5. Interacts with ITPR3. Interacts with MX1 and RNF24. Interacts with FKBP4.

    Alternative splice isoforms for TRPC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRPC1 Gene

Post-translational modifications for TRPC1 Gene

  • Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRPC1 Gene

Domains & Families for TRPC1 Gene

Gene Families for TRPC1 Gene

Suggested Antigen Peptide Sequences for TRPC1 Gene

Graphical View of Domain Structure for InterPro Entry

P48995

UniProtKB/Swiss-Prot:

TRPC1_HUMAN :
  • Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.
Family:
  • Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.
genes like me logo Genes that share domains with TRPC1: view

Function for TRPC1 Gene

Molecular function for TRPC1 Gene

GENATLAS Biochemistry:
transient receptor potential non voltage-channel 1,Drosophila store-operated channel (Soc) homolog,ubiquitous but predominantly expressed in fetal brain,adult heart,brain,testis,ovaries,activated by calcium store depletion component of the capacitative calcium entry channels (homo or heterotetramer)
UniProtKB/Swiss-Prot Function:
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

Gene Ontology (GO) - Molecular Function for TRPC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005261 cation channel activity EXP 18995841
GO:0005262 calcium channel activity TAS --
GO:0005515 protein binding IPI 10097141
GO:0015279 store-operated calcium channel activity TAS 8663995
GO:0070679 inositol 1,4,5 trisphosphate binding IDA 14505576
genes like me logo Genes that share ontologies with TRPC1: view
genes like me logo Genes that share phenotypes with TRPC1: view

Animal Models for TRPC1 Gene

MGI Knock Outs for TRPC1:

Animal Model Products

  • Taconic Biosciences Mouse Models for TRPC1

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TRPC1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRPC1 Gene

Localization for TRPC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRPC1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRPC1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
endoplasmic reticulum 2
cytosol 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TRPC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7568191
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with TRPC1: view

Pathways & Interactions for TRPC1 Gene

genes like me logo Genes that share pathways with TRPC1: view

Gene Ontology (GO) - Biological Process for TRPC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006816 calcium ion transport TAS 8646775
GO:0006828 manganese ion transport IBA --
GO:0042438 melanin biosynthetic process IDA 8126111
genes like me logo Genes that share ontologies with TRPC1: view

No data available for SIGNOR curated interactions for TRPC1 Gene

Drugs & Compounds for TRPC1 Gene

(18) Drugs for TRPC1 Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2-APB Pharma Antagonist, Pore Blocker IP3 receptor antagonist. Also TRP channel modulator 0
Gd<sup>3+</sup> Pharma Channel blocker 0
GsMTx-4 Pharma Channel blocker 0
La<sup>3+</sup> Pharma Pore Blocker 0
SKF96365 Pharma Pore Blocker 0

(4) Additional Compounds for TRPC1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) ApexBio Compounds for TRPC1 Gene

Compound Action Cas Number
Optovin 348575-88-2
SKF 96365 hydrochloride SOCE inhibitor 130495-35-1
WS 3 39711-79-0
genes like me logo Genes that share compounds with TRPC1: view

Drug Products

Transcripts for TRPC1 Gene

Unigene Clusters for TRPC1 Gene

Transient receptor potential cation channel, subfamily C, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TRPC1

Alternative Splicing Database (ASD) splice patterns (SP) for TRPC1 Gene

No ASD Table

Relevant External Links for TRPC1 Gene

GeneLoc Exon Structure for
TRPC1
ECgene alternative splicing isoforms for
TRPC1

Expression for TRPC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRPC1 Gene

Protein differential expression in normal tissues from HIPED for TRPC1 Gene

This gene is overexpressed in Lung (43.3) and Testis (24.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRPC1 Gene



Protein tissue co-expression partners for TRPC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRPC1 Gene:

TRPC1

SOURCE GeneReport for Unigene cluster for TRPC1 Gene:

Hs.250687

mRNA Expression by UniProt/SwissProt for TRPC1 Gene:

P48995-TRPC1_HUMAN
Tissue specificity: Seems to be ubiquitous.

Evidence on tissue expression from TISSUES for TRPC1 Gene

  • Nervous system(4.6)
  • Muscle(2.8)
  • Heart(2.4)
  • Intestine(2.3)
  • Bone marrow(2.2)
  • Lung(2.2)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with TRPC1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRPC1 Gene

Orthologs for TRPC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRPC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRPC1 34 35
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia TRPC1 34 35
  • 95.42 (n)
oppossum
(Monodelphis domestica)
Mammalia TRPC1 35
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRPC1 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRPC1 34 35
  • 94.12 (n)
mouse
(Mus musculus)
Mammalia Trpc1 34 16 35
  • 91.09 (n)
rat
(Rattus norvegicus)
Mammalia Trpc1 34
  • 90.21 (n)
chicken
(Gallus gallus)
Aves TRPC1 34 35
  • 83.4 (n)
lizard
(Anolis carolinensis)
Reptilia TRPC1 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trpc1 34
  • 77.92 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.470 34
zebrafish
(Danio rerio)
Actinopterygii trpc1 34 35
  • 72.63 (n)
fruit fly
(Drosophila melanogaster)
Insecta trpgamma 35
  • 28 (a)
ManyToMany
trpl 35
  • 25 (a)
ManyToMany
trp 35
  • 21 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea trp-1 36
  • 35 (a)
trp-2 35
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
ManyToMany
Species where no ortholog for TRPC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRPC1 Gene

ENSEMBL:
Gene Tree for TRPC1 (if available)
TreeFam:
Gene Tree for TRPC1 (if available)

Paralogs for TRPC1 Gene

Paralogs for TRPC1 Gene

(4) SIMAP similar genes for TRPC1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRPC1: view

Variants for TRPC1 Gene

Sequence variations from dbSNP and Humsavar for TRPC1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs193920786 Uncertain significance 142,784,713(+) TCTCC(C/T)AGTCT nc-transcript-variant, reference, stop-gained
rs1000237413 -- 142,726,032(+) GAAAC(-/AG)AATAT intron-variant
rs1000272023 -- 142,752,507(+) GTACA(A/G)TCGGG intron-variant
rs1000447443 -- 142,759,967(+) CTCCT(G/T)CCCCA intron-variant
rs1000474532 -- 142,775,447(+) AACCC(C/T)GTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRPC1 Gene

Variant ID Type Subtype PubMed ID
dgv300n21 CNV gain 19592680
esv3303979 CNV mobile element insertion 20981092
esv3310329 CNV mobile element insertion 20981092
esv3337166 CNV insertion 20981092
esv3411265 CNV insertion 20981092
esv3569029 CNV loss 25503493
esv3598008 CNV loss 21293372
nsv1000631 CNV gain 25217958
nsv591920 CNV loss 21841781
nsv820119 CNV loss 19587683

Variation tolerance for TRPC1 Gene

Residual Variation Intolerance Score: 9.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.29; 62.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRPC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRPC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRPC1 Gene

Disorders for TRPC1 Gene

Relevant External Links for TRPC1

Genetic Association Database (GAD)
TRPC1
Human Genome Epidemiology (HuGE) Navigator
TRPC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRPC1

No disorders were found for TRPC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRPC1 Gene

Publications for TRPC1 Gene

  1. TRPC1, a human homolog of a Drosophila store-operated channel. (PMID: 7568191) Wes P.D. … Montell C. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 22 64
  2. Protein kinase Calpha phosphorylates the TRPC1 channel and regulates store-operated Ca2+ entry in endothelial cells. (PMID: 15016832) Ahmmed G.U. … Malik A.B. (J. Biol. Chem. 2004) 3 4 22 64
  3. TrpC1 is a membrane-spanning subunit of store-operated Ca(2+) channels in native vascular smooth muscle cells. (PMID: 11139478) Xu S.-Z. … Beech D.J. (Circ. Res. 2001) 3 4 22 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Ca2+ influx via TRPC channels induces NF-kappaB-dependent A20 expression to prevent thrombin-induced apoptosis in endothelial cells. (PMID: 20032510) Thippegowda P.B. … Tiruppathi C. (Am. J. Physiol., Cell Physiol. 2010) 3 22 64

Products for TRPC1 Gene

  • Addgene plasmids for TRPC1

Sources for TRPC1 Gene

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