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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRPC1 Gene

protein-coding   GIFtS: 59
GCID: GC03P142440

transient receptor potential cation channel, subfamily C,...
 Explore 23 diseases affiliated with
TRPC1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TRPC1    

Aliases
for TRPC1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Transient Receptor Potential Cation Channel, Subfamily C, Member 11 2     TRP-12 3
TRP12 3 5     Short Transient Receptor Potential Channel 12
HTRP-11 2     Transient Receptor Potential Canonical 12
Transient Receptor Protein 12 3     TrpC13

External Ids:    HGNC: 123331   Entrez Gene: 72202   Ensembl: ENSG000001449357   OMIM: 6023435   UniProtKB: P489953   

Export aliases for TRPC1 gene to outside databases

Previous GC identifers: GC03P139404 GC03P143271 GC03P143724 GC03P143764 GC03P143925 GC03P139815


Summaries
for TRPC1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TRPC1:
The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and
other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated
phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: TRPC1_HUMAN, P48995
Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a
phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors.
Seems to be also activated by intracellular calcium store depletion

Gene Wiki entry for TRPC1


Genomic Views
for TRPC1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRPC1 gene promoter:
         AP-2rep   HOXA9   HOXA9B   CUTL1   Meis-1b   Evi-1   C/EBPalpha   CHOP-10   FOXO4   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRPC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRPC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRPC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q23   Ensembl cytogenetic band:  3q23   HGNC cytogenetic band: 3q23

TRPC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRPC1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P142440:  view genomic region     (about GC identifiers)

Start:
 142,442,916 bp from pter      End:
 142,526,730 bp from pter
Size:
 83,815 bases      Orientation:
 plus strand

Proteins
for TRPC1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TRPC1_HUMAN, P48995 (See protein sequence)
Recommended Name: Short transient receptor potential channel 1  
Size: 793 amino acids; 91212 Da
Subunit: Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC4 and/or TRPC5. Interacts
with TRPC3, TRPC4 and TRPC5. Interacts with ITPR3. Interacts with MX1 and RNF24. Interacts with FKBP4
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q14CE4
Alternative splicing: 2 isoforms:  P48995-1   P48995-2   

Explore the universe of human proteins at neXtProt for TRPC1: NX_P48995

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P48995

    • TRPC1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001238774.1  NP_003295.1  

    ENSEMBL proteins: 
     ENSP00000419313   ENSP00000273482   ENSP00000418708  
    Reactome Protein details: P48995
    Human Recombinant Protein Products: 
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    Novus Biologicals TRPC1 Protein
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    Uscn Proteins for TRPC1

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS7568191
    GO:0016323basolateral plasma membrane IEA--
    GO:0030017sarcomere IEA--


    TRPC1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TRPC1

    Protein Domains /
    Families
    for TRPC1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TRPC1 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR002153 TRPC_channel
     IPR005457 TRPC1_channel
     IPR020683 Ankyrin_rpt-contain_dom
     IPR005821 Ion_trans_dom
     IPR004729 TRP_channel

    Graphical View of Domain Structure for InterPro Entry P48995

    ProtoNet protein and cluster: P48995

    3 Blocks protein families:
    IPB002153 Transient receptor potential family signature
    IPB005457 Transient receptor potential channel 1 signature
    IPB013555 Transient receptor ion channel II


    UniProtKB/Swiss-Prot: TRPC1_HUMAN, P48995
    Similarity: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily
    Similarity: Contains 4 ANK repeats


    Function
    for TRPC1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TRPC1_HUMAN, P48995
    Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a
    phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors.
    Seems to be also activated by intracellular calcium store depletion

         Genatlas biochemistry entry for TRPC1:
    transient receptor potential non voltage-channel 1,Drosophila store-operated channel (Soc) homolog,ubiquitous but
    predominantly expressed in fetal brain,adult heart,brain,testis,ovaries,activated by calcium store depletion component
    of the capacitative calcium entry channels (homo or heterotetramer)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRPC1
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate TRPC1 (see all 39):
    hsa-miR-142-5p hsa-miR-548j hsa-miR-607 hsa-miR-3616-5p hsa-miR-605 hsa-miR-3653 hsa-miR-186 hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmid: TRPC1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005261cation channel activity EXP--
    GO:0005262calcium channel activity TAS8646775
    GO:0005515protein binding IPI14505576
    GO:0015279store-operated calcium channel activity IEA--
    GO:0044325ion channel binding IPI10097141


    TRPC1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Trpc1tm1Lbi for TRPC1
         5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Trpc1):
     cardiovascular system  digestive/alimentary  endocrine/exocrine gland  growth/size  nervous system 

    TRPC1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TRPC1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    2Role of second messengers in netrin-1 signaling
    		Role of second messengers in netrin-1 signaling1.00
    		Activation of TRPC channels by Netrin-10.60
    3Axon guidance
    		Axon guidance1.00
    		Developmental Biology0.69
    4Signaling by the B Cell Receptor (BCR)
    		Signaling by the B Cell Receptor (BCR)1.00
    5Transcription CREB pathway
    		Transcription CREB pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for TRPC1
        Transcription CREB pathway
    Calcium channels

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TRPC1
        Intracellular Calcium Signaling

    5/9        Reactome Pathways for TRPC1 (see all 9)
        Developmental Biology
    Adaptive Immune System
    Activation of TRPC channels by Netrin-1
    Signaling by the B Cell Receptor (BCR)
    Netrin-1 signaling


    3         Kegg Pathways  (Kegg details for TRPC1):
        Calcium signaling pathway
    Glutamatergic synapse
    Pancreatic secretion


    TRPC1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRPC1

    5/18 Interacting proteins for TRPC1 (P489953) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MX1P205913I2D: score=3 
    BMPR2Q138733I2D: score=2 
    CAV1Q031353I2D: score=2 
    HOMER1Q86YM73I2D: score=2 
    ITPR3Q145733I2D: score=2 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006816calcium ion transport TAS8646775
    GO:0007411axon guidance TAS--
    GO:0046541saliva secretion IEA--
    GO:0051281positive regulation of release of sequestered calcium ion into cytosol IDA19052258
    GO:0051480cytosolic calcium ion homeostasis IDA19052258


    TRPC1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TRPC1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRPC1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for TRPC1

    1 HMDB Compound for TRPC1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    10/14 Novoseek chemical compound relationships for TRPC1 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    skf 96365 84.9 3 20003325 (1), 15972814 (1), 17217049 (1)
    thapsigargin 77.3 16 16899508 (2), 12536150 (1), 12736151 (1), 17224452 (1) (see all 11)
    calcium 68 135 12766172 (6), 16551274 (5), 16283206 (4), 15920022 (4) (see all 50)
    inositol 1,4,5 trisphosphate 65.9 11 12766172 (2), 12161078 (1), 19052258 (1), 10970773 (1) (see all 9)
    capsazepine 50.1 1 16731017 (1)
    jasplakinolide 49.9 1 12196544 (1)
    lanthanum 32.4 3 15728185 (1)
    carbachol 29.9 2 19332491 (1), 15542611 (1)
    inositol 27.9 3 10970773 (1), 18289524 (1)
    ryanodine 27.8 1 11399258 (1)

    Search CenterWatch for drugs/clinical trials and news about TRPC1 

    Transcripts
    for TRPC1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TRPC1 gene (2 alternative transcripts): 
    NM_001251845.1  NM_003304.4  

    Unigene Cluster for TRPC1:

    Transient receptor potential cation channel, subfamily C, member 1
    Hs.250687  [show with all ESTs]
    Unigene Representative Sequence: NM_001251845
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000476941(uc011bni.1) ENST00000273482(uc003evc.3 uc003evb.3)
    ENST00000460401 ENST00000480101

    miRNA
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    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate TRPC1 (see all 39):
    hsa-miR-142-5p hsa-miR-548j hsa-miR-607 hsa-miR-3616-5p hsa-miR-605 hsa-miR-3653 hsa-miR-186 hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmid: TRPC1 3' UTR sequence
    Inhib. RNA
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    Primer
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    Additional cDNA sequence: 

    AB255425.1 BC112338.1 BC113953.1 EF522961.1 GQ293239.1 X89066.1 

    7 DOTS entries:

    DT.443697  DT.99955737  DT.99989787  DT.100831489  DT.92022360  DT.102824421  DT.95259962 

    24/60 AceView cDNA sequences (see all 60):

    AI301172 AI682471 T07204 Z41868 H84832 AA242949 AW949452 BE218965 
    AA258316 W30728 AU123453 AA242814 AI683848 BQ003340 AI560821 BI752497 
    AI765417 AW274590 BQ003330 H85296 AI280444 X89066 BU621066 H09740 

    GeneLoc Exon Structure


    Expression
    for TRPC1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRPC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGTTGAGTTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See TRPC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRPC1

    SOURCE GeneReport for Unigene cluster: Hs.250687

    UniProtKB/Swiss-Prot: TRPC1_HUMAN, P48995
    Tissue specificity: Seems to be ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Array including TRPC1: 
              Neuronal Ion Channels in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for TRPC1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TRPC1 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TRPC11 transient receptor potential cation channel, subfamily more 83.53(n)
    93.57(a)    		   424776  NM_001004409.1  NP_001004409.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TRPC16
    		 --
    		 86(a)
    		 1 ↔ 1
    		 3(21735262-21759923)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.4702 Xenopus laevis cation channel TRP-1 (trp1) mRNA, complete more 78.54(n)    AF113508.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii trpc11 transient receptor potential cation channel, subfamily more 73.13(n)
    84.93(a)    		   570841  NM_001198661.1  NP_001185590.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta trpgamma6
    trpl6
    (see all 3)    		 trp-like
    (see all 3)    		 26(a)
    23(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 2L(16664767-16676666)
    2R(5641202-5653023)
    worm
    (Caenorhabditis elegans)    		 Secernentea trp-13 Transient-receptor-potential (trp) protein 35(a)   III(8607645-8614376)   --


    ENSEMBL Gene Tree for TRPC1 (if available)
    TreeFam Gene Tree for TRPC1 (if available) 

    Paralogs
    for TRPC1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRPC1 gene
    TRPC42  TRPC62  TRPC72  TRPC52  TRPC32  
    5 SIMAP similar genes for TRPC1 using alignment to 3 protein entries:     TRPC1_HUMAN (see all proteins):
    TRPC5    TRPC4    TRP7    TRPC6    TRPC3

    TRPC1 for paralogs           About GeneDecksing



    Genomic Variants
    for TRPC1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1323 NCBI SNPs in TRPC1 are shown (see all 1323)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs616680401,2
    		--139814169(+) AACCTA/GGGAGG 2 -- us2k10--------
    rs738644131,2
    		C,--139815342(+) TAAGTC/AGTCAG 2 -- us2k12Minor allele frequency- A:0.21WA 120
    rs622784921,2
    		C,F,--139815375(+) CATATT/CTGCTT 2 -- us2k14Minor allele frequency- C:0.18WA NA 242
    rs622784931,2
    		C,F,--139815658(+) GCTGGG/CCCAGC 2 -- us2k14Minor allele frequency- C:0.19NA WA 242
    rs763487541,2
    		--139816778(+) CTATTA/CTTTAG 2 -- int11Minor allele frequency- C:0.01EA 120
    rs98771741,2
    		C,F,H,--139816929(+) CCTTTG/TATTGT 2 -- int16Minor allele frequency- T:0.04NS EA WA 518
    rs98776701,2
    		C,F,H,--139817229(+) ATATGG/ACTGTA 2 -- int18Minor allele frequency- A:0.06NS EA NA WA 540
    rs109354671,2
    		C,F,H,--139818825(+) CTAGAG/ATGTCT 2 -- int110Minor allele frequency- A:0.07EA NS NA WA 540
    rs622784951,2
    		C,F,--139819963(+) CTCCCG/AGGTTC 2 -- int14Minor allele frequency- A:0.22NA 126
    rs1179568271,2
    		C,F,--139820195(+) TTCTCC/TATAAG 2 -- int11Minor allele frequency- T:0.02EA 120

    HapMap Linkage Disequilibrium report for TRPC1 (142442916 - 142526730 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for TRPC1
         2 CNVs: 59095 91604

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    Disorders / Diseases
    for TRPC1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TRPC1 for disorders           About GeneDecksing

    OMIM gene information: 602343    OMIM disorders: --

    20/23 diseases for TRPC1 (see all 23):    About MalaCards
    pyloric stenosis    hypertrophic pyloric stenosis    duchenne muscular dystrophy    muscular dystrophy
    polycystic kidney disease    basal cell carcinoma    malignant glioma    bipolar disorder
    neurodegeneration    nephropathy    kidney disease    ischemia
    gingivitis    cerebritis    prostate cancer    breast cancer
    hypoxia    neuroblastoma    retinitis    prostatitis

    5 Novoseek disease relationships for TRPC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 0 3 16551274 (1), 15347566 (1), 17085428 (1)
    inflammation 0 2 16709572 (1), 17023906 (1)
    tumors 0 2 15347566 (1), 17085428 (1)
    neurodegeneration 0 2 15678080 (1), 15542611 (1)
    cerebral ischemia 0 1 16444289 (1)

    Human Genome Epidemiology (HuGE) Navigator: TRPC1 (5 documents)

    Export disorders for TRPC1 gene to outside databases

    Publications
    for TRPC1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRPC1 gene, integrated from 9 sources (see all 210):
    (articles sorted by number of sources associating them with TRPC1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. TRPC1, a human homolog of a Drosophila store-operated channel. (PubMed id 7568191)1, 2, 3, 9 Wes P.D....Montell C. (1995)
    2. TrpC1 is a membrane-spanning subunit of store-operated Ca(2+) channels in native vascular smooth muscle cells. (PubMed id 11139478)1, 2, 9 Xu S.-Z. and Beech D.J. (2001)
    3. Assembly of Trp1 in a signaling complex associated with caveolin- scaffolding lipid raft domains. (PubMed id 10766822)1, 2, 9 Lockwich T.P....Ambudkar I.S. (2000)
    4. Peptidyl-prolyl isomerase FKBP52 controls chemotropic guidance of neuronal growth cones via regulation of TRPC1 channel opening. (PubMed id 19945390)1, 2 Shim S....Worley P.F. (2009)
    5. MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC. (PubMed id 15757897)1, 2 Lussier M.P....Boulay G. (2005)
    6. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. (PubMed id 16382100)1, 3 Clapham D.E....Schultz G. (2005)
    7. Subunit composition of mammalian transient receptor potential channels in living cells. (PubMed id 12032305)1, 2 Hofmann T.... Gudermann T. (2002)
    8. Cloning and functional expression of a human Ca2+-permeable cation channel activated by calcium store depletion. (PubMed id 8663995)1, 2 Zitt C.... Schultz G. (1996)
    9. Molecular cloning of a widely expressed human homologue for the Drosophila trp gene. (PubMed id 7589464)1, 2 Zhu X.... Birnbaumer L. (1995)
    10. TRPC1 Ca(2+)-permeable channels in animal cells. (PubMed id 17217049)1, 9 Rychkov G. and Barritt G.J. (2007)

    External Searches for TRPC1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TRPC1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7220 HGNC: 12333 AceView: TRPC1 Ensembl:ENSG00000144935 euGenes: HUgn7220
    ECgene: TRPC1 Kegg: 7220 H-InvDB: TRPC1

    Other Databases showing TRPC1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TRPC1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRPC1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TRPC1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TRPC1 gene:
    Search GeneIP for patents involving TRPC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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