Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TRPC1 Gene

protein-coding   GIFtS: 61
GCID: GC03P142440

Transient Receptor Potential Cation Channel, Subfamily C,...

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Transient Receptor Potential Cation Channel, Subfamily C, Member 11 2     Capacitative Calcium Channel Protein Trp12
TRP12 3 5     Short Transient Receptor Potential Channel 12
Transient Receptor Protein 12 3     Transient Receptor Potential Canonical 12
TRP-12 3     TrpC13
HTRP-12     

External Ids:    HGNC: 123331   Entrez Gene: 72202   Ensembl: ENSG000001449357   OMIM: 6023435   UniProtKB: P489953   

Export aliases for TRPC1 gene to outside databases

Previous GC identifers: GC03P139404 GC03P143271 GC03P143724 GC03P143764 GC03P143925 GC03P139815


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TRPC1 Gene:
The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium
and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine
kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium
stores. Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq,
Oct 2011)

GeneCards Summary for TRPC1 Gene:
TRPC1 (transient receptor potential cation channel, subfamily C, member 1) is a protein-coding gene. Diseases associated with TRPC1 include hypertrophic pyloric stenosis, and pyloric stenosis. GO annotations related to this gene include store-operated calcium channel activity and ion channel binding. An important paralog of this gene is TRPC4.

UniProtKB/Swiss-Prot: TRPC1_HUMAN, P48995
Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated
by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled
receptors. Seems to be also activated by intracellular calcium store depletion

Gene Wiki entry for TRPC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRPC1 gene promoter:
         AP-2rep   HOXA9   HOXA9B   CUTL1   Meis-1b   Evi-1   C/EBPalpha   CHOP-10   FOXO4   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRPC1 promoter sequence
   Search Chromatin IP Primers for TRPC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRPC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q23   Ensembl cytogenetic band:  3q23   HGNC cytogenetic band: 3q23

TRPC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRPC1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P142440:  view genomic region     (about GC identifiers)

Start:
142,442,916 bp from pter      End:
142,526,730 bp from pter
Size:
83,815 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TRPC1_HUMAN, P48995 (See protein sequence)
Recommended Name: Short transient receptor potential channel 1  
Size: 793 amino acids; 91212 Da
Subunit: Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC4 and/or TRPC5.
Interacts with TRPC3, TRPC4 and TRPC5. Interacts with ITPR3. Interacts with MX1 and RNF24. Interacts with FKBP4
Secondary accessions: Q14CE4
Alternative splicing: 2 isoforms:  P48995-1   P48995-2   

Explore the universe of human proteins at neXtProt for TRPC1: NX_P48995

Explore proteomics data for TRPC1 at MOPED

Post-translational modifications: 

  • Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TRPC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001238774.1  NP_003295.1  

    ENSEMBL proteins: 
     ENSP00000419313   ENSP00000273482   ENSP00000418708  
    Reactome Protein details: P48995

    TRPC1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TRPC1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TRPC1
    GenScript Custom Purified and Recombinant Proteins Services for TRPC1
    Novus Biologicals TRPC1 Protein
    Novus Biologicals TRPC1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRPC1

    TRPC1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TRPC1
    OriGene Custom Antibody Services for TRPC1
    Novus Biologicals TRPC1 Antibodies
    Abcam antibodies for TRPC1
    Cloud-Clone Corp. Antibodies for TRPC1
    ThermoFisher Antibodies for TRPC1
    LSBio Antibodies in human, mouse, rat for TRPC1

    TRPC1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TRPC1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRPC1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TRPC1
    Cloud-Clone Corp. CLIAs for TRPC1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    TRP: Voltage-gated ion channels / Transient receptor potential cation channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: TRPC1
    Transient Receptor Potential channels

    Selected InterPro protein domains (see all 7):
     IPR002153 TRPC_channel
     IPR005457 TRPC1_channel
     IPR005821 Ion_trans_dom
     IPR004729 TRP_channel
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry P48995

    ProtoNet protein and cluster: P48995

    3 Blocks protein domains:
    IPB002153 Transient receptor potential family signature
    IPB005457 Transient receptor potential channel 1 signature
    IPB013555 Transient receptor ion channel II


    UniProtKB/Swiss-Prot: TRPC1_HUMAN, P48995
    Similarity: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily
    Similarity: Contains 4 ANK repeats


    TRPC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRPC1_HUMAN, P48995
    Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated
    by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled
    receptors. Seems to be also activated by intracellular calcium store depletion

         Genatlas biochemistry entry for TRPC1:
    transient receptor potential non voltage-channel 1,Drosophila store-operated channel (Soc) homolog,ubiquitous but
    predominantly expressed in fetal brain,adult heart,brain,testis,ovaries,activated by calcium store depletion
    component of the capacitative calcium entry channels (homo or heterotetramer)

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005261cation channel activity EXP--
    GO:0005262calcium channel activity TAS8646775
    GO:0005515protein binding IPI14505576
    GO:0015279store-operated calcium channel activity IEA--
         
    TRPC1 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Trpc1):
     behavior/neurological  cardiovascular system  digestive/alimentary  endocrine/exocrine gland  growth/size/body 
     nervous system 

    TRPC1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Trpc1tm1Lbi for TRPC1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRPC1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRPC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRPC1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRPC1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRPC1:
    hsa-mir-124-3p (MIRT023057), hsa-mir-215-5p (MIRT024528), hsa-mir-335-5p (MIRT018877), hsa-mir-615-3p (MIRT039618), hsa-mir-192-5p (MIRT026862)

    Block miRNA regulation of human, mouse, rat TRPC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRPC1 (see all 39):
    hsa-miR-142-5p hsa-miR-548j hsa-miR-607 hsa-miR-3616-5p hsa-miR-605 hsa-miR-3653 hsa-miR-186 hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidTRPC1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRPC1
    Predesigned siRNA for gene silencing in human, mouse, rat TRPC1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRPC1

    Clone
    Products:
         
    OriGene clones in human, mouse for TRPC1 (see all 6)
    OriGene ORF clones in mouse, rat for TRPC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRPC1 (NM_003304)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRPC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPC1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TRPC1
    Browse ESI BIO Cell Lines and PureStem Progenitors for TRPC1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TRPC1_HUMAN, P48995: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytoskeleton2
    endoplasmic reticulum2
    extracellular2
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7568191
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    TRPC1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TRPC1 About   (see all 13)                                                                                              See pathways by source

    SuperPathContained pathways About
    1L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    2Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58
    3Circadian entrainment
    Glutamatergic synapse0.39
    Serotonergic synapse0.33
    4Netrin-1 signaling
    Netrin-1 signaling
    Role of second messengers in netrin-1 signaling0.00
    5Downstream Signaling Events Of B Cell Receptor (BCR)
    Signaling by the B Cell Receptor (BCR)0.79

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TRPC1
        Intracellular Calcium Signaling

    3 Reactome Pathways for TRPC1
        TRP channels
    Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
    Role of second messengers in netrin-1 signaling


    3 Kegg Pathways  (Kegg details for TRPC1):
        Glutamatergic synapse
    Serotonergic synapse
    Pancreatic secretion


    TRPC1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including TRPC1: 
              Neuronal Ion Channels in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TRPC1

    Selected Interacting proteins for TRPC1 (P489953) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MX1P205913I2D: score=3 
    BMPR2Q138733I2D: score=2 
    CAV1Q031353I2D: score=2 
    HOMER1Q86YM73I2D: score=2 
    ITPR3Q145733I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0006816calcium ion transport TAS8646775
    GO:0007411axon guidance TAS--
    GO:0034220ion transmembrane transport TAS--
    GO:0046541saliva secretion IEA--

    TRPC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRPC1

    1 HMDB Compound for TRPC1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    5 IUPHAR Ligands for TRPC1 (TRPC1)    About this table
    LigandTypeActionAffinityPubmed IDs
    SKF96365
    Channel blockerNone--
    GsMTx-4
    Channel blockerNone--
    La3+
    Pore BlockerAntagonist11301024
    Gd3+
    Pore BlockerAntagonist8663995
    2-APB
    Pore BlockerAntagonist11301024

    Selected Novoseek inferred chemical compound relationships for TRPC1 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    skf 96365 84.9 3 20003325 (1), 15972814 (1), 17217049 (1)
    thapsigargin 77.3 16 16899508 (2), 12536150 (1), 12736151 (1), 17224452 (1) (see all 11)
    calcium 68 135 12766172 (6), 16551274 (5), 16283206 (4), 15920022 (4) (see all 50)
    inositol 1,4,5 trisphosphate 65.9 11 12766172 (2), 12161078 (1), 19052258 (1), 10970773 (1) (see all 9)
    capsazepine 50.1 1 16731017 (1)
    jasplakinolide 49.9 1 12196544 (1)
    lanthanum 32.4 3 15728185 (1)
    carbachol 29.9 2 19332491 (1), 15542611 (1)
    inositol 27.9 3 10970773 (1), 18289524 (1)
    ryanodine 27.8 1 11399258 (1)



    TRPC1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TRPC1 gene (2 alternative transcripts): 
    NM_001251845.1  NM_003304.4  

    Unigene Cluster for TRPC1:

    Transient receptor potential cation channel, subfamily C, member 1
    Hs.250687  [show with all ESTs]
    Unigene Representative Sequence: NM_001251845
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000476941(uc011bni.1) ENST00000273482(uc003evc.3 uc003evb.3)
    ENST00000460401 ENST00000480101

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TRPC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRPC1 (see all 39):
    hsa-miR-142-5p hsa-miR-548j hsa-miR-607 hsa-miR-3616-5p hsa-miR-605 hsa-miR-3653 hsa-miR-186 hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidTRPC1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TRPC1
    Predesigned siRNA for gene silencing in human, mouse, rat TRPC1
    Clone
    Products:
         
    OriGene clones in human, mouse for TRPC1 (see all 6)
    OriGene ORF clones in mouse, rat for TRPC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRPC1 (NM_003304)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRPC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPC1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TRPC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRPC1
      QuantiTect SYBR Green Assays in human, mouse, rat TRPC1
      QuantiFast Probe-based Assays in human, mouse, rat TRPC1

    Additional mRNA sequence: 

    AB255425.1 BC112338.1 BC113953.1 EF522961.1 GQ293239.1 X89066.1 

    7 DOTS entries:

    DT.443697  DT.99955737  DT.99989787  DT.100831489  DT.92022360  DT.102824421  DT.95259962 

    Selected AceView cDNA sequences (see all 60):

    AA242949 AW949452 Z41868 H84832 AI682471 T07204 BE218965 AI301172 
    W30728 BQ003340 AI560821 AI683848 AU123453 AA242814 AA258316 AI765417 
    NM_003304 BI752497 BU621066 BF476749 X89066 AI280444 AW274590 BQ003330 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TRPC1 expression in normal human tissues (normalized intensities)      TRPC1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTGAGTTG
    TRPC1 Expression
    About this image


    TRPC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Gonad
             XX Germ Cells Ovigerous Cord
    TRPC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRPC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.250687

    UniProtKB/Swiss-Prot: TRPC1_HUMAN, P48995
    Tissue specificity: Seems to be ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Array including TRPC1: 
              Neuronal Ion Channels in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TRPC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRPC1
    QuantiTect SYBR Green Assays in human, mouse, rat TRPC1
    QuantiFast Probe-based Assays in human, mouse, rat TRPC1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for TRPC1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trpc11 , 5 transient receptor potential cation channel, subfamily more1, 5 91.09(n)1
    99.75(a)1
      9 (50.20 cM)5
    220631  NM_011643.21  NP_035773.11 
     957066275 
    chicken
    (Gallus gallus)
    Aves TRPC11 transient receptor potential cation channel, subfamily more 83.4(n)
    93.47(a)
      424776  NM_001004409.2  NP_001004409.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRPC16
    transient receptor potential cation channel, subfa...
    86(a)
    1 ↔ 1
    3(21735262-21760289)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.4702 Xenopus laevis cation channel TRP-1 (trp1) mRNA, complete more 78.54(n)    AF113508.1 
    zebrafish
    (Danio rerio)
    Actinopterygii trpc11 transient receptor potential cation channel, subfamily more 72.63(n)
    84.43(a)
      570841  NM_001198661.2  NP_001185590.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta trpgamma6
    trpl6
    (see all 3)
    trp-like
    (see all 3)
    28(a)
    25(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    2L(16664767-16676666)
    2R(5641202-5653023)
    worm
    (Caenorhabditis elegans)
    Secernentea trp-13 Transient-receptor-potential (trp)
    protein
    35(a)   III(8607645-8614376)   --


    ENSEMBL Gene Tree for TRPC1 (if available)
    TreeFam Gene Tree for TRPC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TRPC1 gene
    TRPC42  TRPC72  TRPC62  TRPC52  TRPC32  
    4 SIMAP similar genes for TRPC1 using alignment to 3 protein entries:     TRPC1_HUMAN (see all proteins):
    TRPC5    TRPC4    TRP7    TRPC6

    TRPC1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TRPC1 (see all 1564)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs616680401,2
    C--142418756(+) AACCTA/GGGAGG 2 -- us2k10--------
    rs1416012381,2
    C--142418940(+) TCCAAC/GTCAAA 2 -- us2k10--------
    rs1417023591,2
    C--142419300(+) CTGTG-/ATATAT
            
    ATATA
    2 -- us2k10--------
    rs1500820181,2
    --142419329(+) GTGGTA/GTATAT 2 -- us2k10--------
    rs1822217411,2
    --142419345(+) TGATAC/TATATA 2 -- us2k10--------
    rs1385434411,2
    --142419375(+) AGCCAC/TAAAAA 2 -- us2k10--------
    rs2005448331,2
    C--142419427(+) GAGAC-/TATTATTC 2 -- us2k10--------
    rs1415465861,2
    --142419539(+) ACACAA/GTGGAC 2 -- us2k10--------
    rs1854622471,2
    --142419632(+) GGGTAC/TATCAA 2 -- us2k10--------
    rs1462043611,2
    --142419819(+) ATGAGC/TACAAC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TRPC1 (142442916 - 142526730 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TRPC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv274601CNV Insertion20981092
    esv268258CNV Insertion20981092
    nsv820119CNV Loss19587683
    dgv300n21CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRPC1
    DNA2.0 Custom Variant and Variant Library Synthesis for TRPC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602343    OMIM disorders: --

    Selected diseases for TRPC1 (see all 27):    About MalaCards
    hypertrophic pyloric stenosis    pyloric stenosis    duchenne muscular dystrophy    burns
    polycystic kidney disease    kidney disease    diabetic nephropathy    basal cell carcinoma
    malignant glioma    muscular dystrophy    gingivitis    ischemia
    bipolar disorder    endotheliitis    cerebritis    nasopharyngitis
    hypoxia    tonsillitis    neuroblastoma    retinitis


    TRPC1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    5 Novoseek inferred disease relationships for TRPC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 0 3 16551274 (1), 15347566 (1), 17085428 (1)
    inflammation 0 2 16709572 (1), 17023906 (1)
    tumors 0 2 15347566 (1), 17085428 (1)
    neurodegeneration 0 2 15678080 (1), 15542611 (1)
    cerebral ischemia 0 1 16444289 (1)

    Genetic Association Database (GAD): TRPC1
    Human Genome Epidemiology (HuGE) Navigator: TRPC1 (5 documents)

    Export disorders for TRPC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TRPC1 gene, integrated from 10 sources (see all 218):
    (articles sorted by number of sources associating them with TRPC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TRPC1, a human homolog of a Drosophila store-operated channel. (PubMed id 7568191)1, 2, 3, 9 Wes P.D....Montell C. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    2. Protein kinase Calpha phosphorylates the TRPC1 channel and regulates store-operated Ca2+ entry in endothelial cells. (PubMed id 15016832)1, 2, 9 Ahmmed G.U.... Malik A.B. (J. Biol. Chem. 2004)
    3. TrpC1 is a membrane-spanning subunit of store-operated Ca(2+) channels in native vascular smooth muscle cells. (PubMed id 11139478)1, 2, 9 Xu S.-Z. and Beech D.J. (Circ. Res. 2001)
    4. Assembly of Trp1 in a signaling complex associated with caveolin- scaffolding lipid raft domains. (PubMed id 10766822)1, 2, 9 Lockwich T.P....Ambudkar I.S. (J. Biol. Chem. 2000)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Evaluation of genetic association and expression reduction of TRPC1 in the development of diabetic nephropathy. (PubMed id 18802326)1, 4 Zhang D....Gu H.F. (Am. J. Nephrol. 2009)
    7. Infantile hypertrophic pyloric stenosis: evaluation of three positional candidate genes, TRPC1, TRPC5 and TRPC6, by association analysis and re-sequencing. (PubMed id 19701773)1, 4 Everett K.V....Chung E.M. (Hum. Genet. 2009)
    8. Peptidyl-prolyl isomerase FKBP52 controls chemotropic guidance of neuronal growth cones via regulation of TRPC1 channel opening. (PubMed id 19945390)1, 2 Shim S.... Worley P.F. (Neuron 2009)
    9. MxA, a member of the dynamin superfamily, interacts with the ankyrin- like repeat domain of TRPC. (PubMed id 15757897)1, 2 Lussier M.P.... Boulay G. (J. Biol. Chem. 2005)
    10. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. (PubMed id 16382100)1, 3 Clapham D.E....Schultz G. (Pharmacol. Rev. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7220 HGNC: 12333 AceView: TRPC1 Ensembl:ENSG00000144935 euGenes: HUgn7220
    ECgene: TRPC1 Kegg: 7220 H-InvDB: TRPC1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TRPC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TRPC1 gene:
    Search GeneIP for patents involving TRPC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TRPC1   OriGene RNAi products in human, mouse, rat for TRPC1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for TRPC1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TRPC1  
     OriGene qSTAR qPCR primer pairs in human, mouse for TRPC1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TRPC1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TRPC1   OriGene Custom Protein Services for TRPC1  

     
     
     Block miRNA regulation of human, mouse, rat TRPC1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TRPC1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRPC1 Predesigned siRNA for gene silencing in human, mouse, rat TRPC1
     QuantiFast Probe-based Assays in human, mouse, rat TRPC1 QuantiTect SYBR Green Assays in human, mouse, rat TRPC1
     PCR Arrays including human, mouse, rat TRPC1 Search Chromatin IP Primers for TRPC1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRPC1  GeneGlobe Interaction Network for TRPC1
     Regulatory tfbs in TRPC1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TRPC1 GenScript cDNA clones with any tag delivered in your preferred vector for TRPC1
     GenScript Custom Assay Services for TRPC1 GenScript Custom overexpressing Cell Line Services for TRPC1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TRPC1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TRPC1 antibodies
     TRPC1 proteins
     TRPC1 lysates
     Antibodies for TRPC1
     See all of Abcam's Antibodies, Kits and Proteins for TRPC1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TRPC1
     Antibodies for TRPC1
     ELISAs for TRPC1
     CLIAs for TRPC1



     Browse ESI BIO Cell Lines and PureStem Progenitors for TRPC1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPC1
     SwitchGear 3'UTR luciferase reporter plasmids for TRPC1
     SwitchGear Promoter luciferase reporter plasmids for TRPC1
     ThermoFisher Antibodies for TRPC1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPC1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRPC1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRPC1
     LSBio Antibodies in human, mouse, rat for TRPC1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TRPC1 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4