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TRPA1 Gene

protein-coding   GIFtS: 63
GCID: GC08M072932

Transient Receptor Potential Cation Channel, Subfamily A,...

(Previous name: ankyrin-like with transmembrane domains 1)
(Previous symbol: ANKTM1)
  See TRPA1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transient Receptor Potential Cation Channel, Subfamily A, Member 11 2     FEPS2 5
ANKTM11 2 3 5     Transient Receptor Potential Cation Channel Subfamily A Member 12
Ankyrin-Like With Transmembrane Domains 11 2     Ankyrin-Like With Transmembrane Domains Protein 13
Transformation-Sensitive Protein P1202 3     

External Ids:    HGNC: 4971   Entrez Gene: 89892   Ensembl: ENSG000001043217   OMIM: 6047755   UniProtKB: O757623   

Export aliases for TRPA1 gene to outside databases

Previous GC identifers: GC08M072983 GC08M073096 GC08M068428


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRPA1 Gene:
The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane
proteins. The specific function of this protein has not yet been determined; however, studies indicate the
function may involve a role in signal transduction and growth control. (provided by RefSeq, Jul 2008)

GeneCards Summary for TRPA1 Gene:
TRPA1 (transient receptor potential cation channel, subfamily A, member 1) is a protein-coding gene. Diseases associated with TRPA1 include episodic pain syndrome, familial, and somatoform disorder. GO annotations related to this gene include calcium channel activity and channel activity. An important paralog of this gene is ANKRD16.

UniProtKB/Swiss-Prot: TRPA1_HUMAN, O75762
Function: Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold
perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators
and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears
gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by
delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation.
May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby
participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system
(By similarity)

summary for TRPA1 Gene:
TRPA1 is a member of the transient receptor potential (TRP) superfamily of ion channels. TRPA1 is classed as
a thermoTRP: a TRP channel which is gated by temperature and functions as a temperature transducer. This
channel is thought to be indirectly activated by cold; it is often expressed in the same neurons as TRPV1,
another thermoTRP, which senses heat.

Gene Wiki entry for TRPA1 (Transient receptor potential cation channel, member A1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TRPA1 gene promoter:
         ER-alpha   HFH-3   Tal-1beta   NF-AT   FOXI1   NF-AT4   NF-AT2   NF-AT3   ITF-2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRPA1 promoter sequence
   Search Chromatin IP Primers for TRPA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRPA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q13   Ensembl cytogenetic band:  8q13.3   HGNC cytogenetic band: 8q13

TRPA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRPA1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M072932:  view genomic region     (about GC identifiers)

Start:
72,932,152 bp from pter      End:
72,987,852 bp from pter
Size:
55,701 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TRPA1_HUMAN, O75762 (See protein sequence)
Recommended Name: Transient receptor potential cation channel subfamily A member 1  
Size: 1119 amino acids; 127501 Da
Subunit: Homotetramer (By similarity)
Secondary accessions: A6NIN6

Explore the universe of human proteins at neXtProt for TRPA1: NX_O75762

Explore proteomics data for TRPA1 at MOPED

Post-translational modifications: 

  • TRPA1 activation by electrophiles occurs though covalent modification of specific cysteine residues in the
    N-terminal cytoplasmic domain (By similarity)1
  • Glycosylation2 at Asn747, Asn753
  • Modification sites at PhosphoSitePlus

  • See TRPA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_015628.2  
    ENSEMBL proteins: 
     ENSP00000428151   ENSP00000262209  
    Reactome Protein details: O75762

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TRP: Voltage-gated ion channels / Transient receptor potential cation channels
    ANKRD: Ankyrin repeat domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: TRPA1
    Transient Receptor Potential channels

    3 InterPro protein domains:
     IPR005821 Ion_trans_dom
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry O75762

    ProtoNet protein and cluster: O75762

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: TRPA1_HUMAN, O75762
    Similarity: Belongs to the transient receptor (TC 1.A.4) family
    Similarity: Contains 15 ANK repeats


    Find genes that share domains with TRPA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRPA1_HUMAN, O75762
    Function: Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold
    perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators
    and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears
    gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by
    delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation.
    May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby
    participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system
    (By similarity)
    Enzyme regulation: Inhibited by ruthenium red, a potent blocker of TRPV channels (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005262calcium channel activity IEA--
    GO:0005515protein binding ----
    GO:0015267channel activity TAS10066796
         
    Find genes that share ontologies with TRPA1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for TRPA1:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         10 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Trpa1):
     behavior/neurological  hearing/vestibular/ear  homeostasis/metabolism  immune system  integument 
     nervous system  no phenotypic analysis  normal  respiratory system  taste/olfaction 

    Find genes that share phenotypes with TRPA1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TRPA1: Trpa1tm1.1Kykw Trpa1tm2.1Kykw Trpa1tm1Kykw Trpa1tm1Jul

       genOway: Develop your customized and physiologically relevant rodent model for TRPA1

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    SwitchGear 3'UTR luciferase reporter plasmidTRPA1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRPA1_HUMAN, O75762: Membrane; Multi-pass membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS10066796
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----
    GO:0032421stereocilium bundle IEA--

    Find genes that share ontologies with TRPA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TRPA1 About    
    See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    3Development Endothelin 1 EDNRA signaling
    Inflammatory mediator regulation of TRP channels0.37
    4TRP channels
    TRP channels
    5Calcium channels
    Calcium channels


    Find genes that share SuperPaths with TRPA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for TRPA1
        TRP channels


    1 Kegg Pathway  (Kegg details for TRPA1):
        Inflammatory mediator regulation of TRP channels

        Pathway & Disease-focused RT2 Profiler PCR Array including TRPA1: 
              Neuronal Ion Channels in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TRPA1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for TRPA1 (O757623 ENSP000002622094) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYLDQ9NQC73, ENSP000003089284I2D: score=2 STRING: ENSP00000308928
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS10066796
    GO:0006816calcium ion transport ----
    GO:0009409response to cold IEA--
    GO:0034220ion transmembrane transport TAS--
    GO:0042493response to drug IEA--

    Find genes that share ontologies with TRPA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for TRPA1
      Browse compounds at ApexBio 

    Compounds for TRPA1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TCS 5861528TRPA1 blocker[332117-28-9]
    AP 18Reversible TRPA1 channel blocker[55224-94-7]
    IcilinActivates a novel cold receptor. Cooling agent[36945-98-9]
    A 967079Selective TRPA1 channel blocker[1170613-55-4]
    HC 030031Selective TRPA1 blocker[349085-38-7]

    1 HMDB Compound for TRPA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Menthol(-)-(1R,3R,4S)-Menthol (see all 21)2216-51-5--

    1 DrugBank Compound for TRPA1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Menthol(-)-menthol (see all 5)2216-51-5targetinducer12654248 11752352 15931068 16829128

    Selected IUPHAR Ligands for TRPA1 (TRPA1) (see all 39)    About this table
    LigandTypeActionAffinityPubmed IDs
    PF-4840154
    ActivatorActivation7.621741838
    SC-51089
    ActivatorActivation7.218501939
    A-967079
    Gating inhibitorInhibition7.221402443
    1'-acetoxychavicol acetate
    ActivatorActivation6.820699565
    chloropicrin
    ActivatorActivation6.719036859
    omega-chloroacetophenone
    ActivatorActivation6.618501939
    NPPB
    ActivatorActivation6.4920226176
    benzoquinone
    ActivatorActivation6.422109525
    isovelleral
    ActivatorActivation6.318550530
    bromoacetone
    ActivatorActivation619036859

    2 Novoseek inferred chemical compound relationships for TRPA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    allyl isothiocyanate 87 3 19171673 (1), 19220220 (1), 19888597 (1)
    capsaicin 76.9 4 19171673 (2), 19074743 (1), 19939193 (1)



    Find genes that share compounds with TRPA1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRPA1 gene: 
    NM_007332.2  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000523582 ENST00000262209(uc003xza.3) ENST00000520596 ENST00000519720
    ENST00000522271 ENST00000520788
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    17 AceView cDNA sequences:

    AA972567 BF438124 AA502609 AI340031 BE348330 BX479572 AI879472 NM_007332 
    Y10601 BX482652 BX504580 BG185430 BX472444 BF570694 BE153109 BE153179 
    BE153213 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRPA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGAAATATTT
    TRPA1 Expression
    About this image


    TRPA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     NULL (Uncategorized)    fully expand to see all 3 entries
             Definitive endoderm-like cells
    TRPA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRPA1 Protein Expression

    UniProtKB/Swiss-Prot: TRPA1_HUMAN, O75762
    Tissue specificity: Expressed at very low level. Expressed at very low level in human fibroblasts and at a
    moderate level in liposarcoma cells

        Pathway & Disease-focused RT2 Profiler PCR Array including TRPA1: 
              Neuronal Ion Channels in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TRPA1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trpa11 , 5 transient receptor potential cation channel, subfamily more1, 5 81.06(n)1
    80.43(a)1
      1 (4.50 cM)5
    2773281  NM_177781.41  NP_808449.11 
     148726485 
    chicken
    (Gallus gallus)
    Aves TRPA11 transient receptor potential cation channel, subfamily more 67.99(n)
    63.06(a)
      420180  XM_418294.4  XP_418294.4 
    lizard
    (Anolis carolinensis)
    Reptilia TRPA16
    transient receptor potential cation channel, subfa...
    57(a)
    1 ↔ 1
    4(33024280-33063118)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia trpa11 transient receptor potential cation channel, subfamily more 60.98(n)
    55.23(a)
      100158526  NM_001127962.1  NP_001121434.1 
    zebrafish
    (Danio rerio)
    Actinopterygii trpa1a1 transient receptor potential cation channel, subfamily more 55.3(n)
    50.05(a)
      474351  NM_001007065.1  NP_001007066.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta TrpA11 Transient receptor potential A1 47.01(n)
    38.57(a)
      39015  NM_140006.5  NP_648263.5 
    worm
    (Caenorhabditis elegans)
    Secernentea trpa-11 trpa-1 43.78(n)
    30.12(a)
      178118  NM_069848.4  NP_502249.3 


    ENSEMBL Gene Tree for TRPA1 (if available)
    TreeFam Gene Tree for TRPA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRPA1 gene
    ANKRD162  
    6 SIMAP similar genes for TRPA1 using alignment to 2 protein entries:     TRPA1_HUMAN (see all proteins):
    NRARP    ANKRD42    GABPB1    RAI14    IkBa    PSMD10

    Find genes that share paralogs with TRPA1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TRPA1
    PGOHUM00000257192


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRPA1 (see all 525)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0697374
    Episodic pain syndrome, familial, 1 (FEPS1)4--see VAR_0697372 N S mis40--------
    rs1997051861,2
    C--72969144(+) AGATAC/TACATT 1 -- int10--------
    rs617363131,2
    C,F--72969228(+) CAAAAT/ATATCT 2 /N /I mis12Minor allele frequency- A:0.03NS NA 4260
    rs37797521,2
    C,F,A,H--72969263(+) AAAAAA/CCACTA 1 -- int114Minor allele frequency- C:0.14NS EA NA 1932
    rs1437893541,2
    --72969370(+) GTTTAC/TAGGAA 1 -- int10--------
    rs1922389111,2
    --72969430(+) ACTCTC/GTGTGT 1 -- int10--------
    rs1508896481,2
    --72969431(+) CTCTC-/TGTGTGT 1 -- int10--------
    rs1384025751,2
    C--72969517(+) AAGCAC/TAAAAT 1 -- int10--------
    rs1842573711,2
    --72969564(+) GATAGA/CAGAGA 1 -- int10--------
    rs1429221661,2
    --72969573(+) GAAGGA/TCACCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for TRPA1 (72932152 - 72987852 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TRPA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2737154CNV Deletion23290073
    esv2737155CNV Deletion23290073
    esv2737156CNV Deletion23290073
    esv1942504CNV Deletion18987734
    nsv831353CNV Loss17160897
    esv6851CNV Gain19470904

    Human Gene Mutation Database (HGMD): TRPA1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRPA1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604775   
    OMIM disorders: 615040  
    UniProtKB/Swiss-Prot: TRPA1_HUMAN, O75762
  • Episodic pain syndrome, familial, 1 (FEPS1) [MIM:615040]: An autosomal dominant neurologic disorder
    characterized by onset in infancy of episodic debilitating upper body pain triggered by fasting, cold, and
    physical stress. The period of intense pain is accompanied by breathing difficulties, tachycardia, sweating,
    generalized pallor, peribuccal cyanosis, and stiffness of the abdominal wall. Affected individuals do not
    manifest altered pain sensitivity outside the episodes. Note=The disease is caused by mutations affecting the
    gene represented in this entry

  • 5 diseases for TRPA1:    
    About MalaCards
    episodic pain syndrome, familial    somatoform disorder    dentin sensitivity    pain agnosia
    agnosia

    2 diseases from the University of Copenhagen DISEASES database for TRPA1:
    Dentin sensitivity     Pain agnosia

    Find genes that share disorders with TRPA1           About GenesLikeMe

    1 Novoseek inferred disease relationship for TRPA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperalgesia 57.8 7 19939193 (2), 18086308 (1)

    Genetic Association Database (GAD): TRPA1
    Human Genome Epidemiology (HuGE) Navigator: TRPA1 (2 documents)

    Export disorders for TRPA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRPA1 gene, integrated from 10 sources (see all 94):
    (articles sorted by number of sources associating them with TRPA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome. (PubMed id 20547126)1, 2 Kremeyer B....Ruiz-Linares A. (Neuron 2010)
    2. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. (PubMed id 16382100)1, 3 Clapham D.E....Schultz G. (Pharmacol. Rev. 2005)
    3. An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts. (PubMed id 10066796)1, 2 Jaquemar D.... Trueb B. (J. Biol. Chem. 1999)
    4. QGP-1 cells release 5-HT via TRPA1 activation; a model of human enterochromaffin cells. (PubMed id 19507004)1, 9 Doihara H....Ito H. (Mol. Cell. Biochem. 2009)
    5. TRPA1 is a substrate for de-ubiquitination by the tumor suppressor CYLD. (PubMed id 16500080)1, 9 Stokes A....Turner H. (Cell. Signal. 2006)
    6. Differentiation dependent expression of TRPA1 and TRPM8 channels in IMR-32 human neuroblastoma cells. (PubMed id 19507192)1, 9 Louhivuori L.M....Akerman K.E. (J. Cell. Physiol. 2009)
    7. Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. (PubMed id 19074743)1, 9 Bessac B.F. and Jordt S.E. (Physiology (Bethesda) 2008)
    8. TRPA1 and TRPM8 activation in humans: effects of cinnamaldehyde and menthol. (PubMed id 15931068)7, 9 Namer B....MaihAPfner C. (Neuroreport 2005)
    9. Modulation of transient receptor vanilloid 1 activity by transient receptor potential ankyrin 1. (PubMed id 24275229)1 Spahn V....ZAPllner C. (Mol. Pharmacol. 2014)
    10. Rhinovirus upregulates transient receptor potential channels in a human neuronal cell line: implications for respiratory virus-induced cough reflex sensitivity. (PubMed id 24002057)1 Abdullah H....McGarvey L.P. (Thorax 2014)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8989 HGNC: 497 AceView: TRPA1 Ensembl:ENSG00000104321 euGenes: HUgn8989
    ECgene: TRPA1 Kegg: 8989 H-InvDB: TRPA1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRPA1 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/082

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRPA1 gene:
    Search GeneIP for patents involving TRPA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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