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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRPA1 Gene

protein-coding   GIFtS: 63
GCID: GC08M072983

Transient Receptor Potential Cation Channel, Subfamily A,...

(Previous name: ankyrin-like with transmembrane domains 1)
(Previous symbol: ANKTM1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transient Receptor Potential Cation Channel, Subfamily A, Member 11 2     Transformation-Sensitive Protein P1202 3
ANKTM11 2 3 5     FEPS2
Ankyrin-Like With Transmembrane Domains 11 2     Transient Receptor Potential Cation Channel Subfamily A Member 12
Ankyrin-Like With Transmembrane Domains Protein 12 3     

External Ids:    HGNC: 4971   Entrez Gene: 89892   Ensembl: ENSG000001043217   OMIM: 6047755   UniProtKB: O757623   

Export aliases for TRPA1 gene to outside databases

Previous GC identifers: GC08M073096 GC08M068428


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRPA1 Gene:
The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane
proteins. The specific function of this protein has not yet been determined; however, studies indicate the
function may involve a role in signal transduction and growth control. (provided by RefSeq, Jul 2008)

GeneCards Summary for TRPA1 Gene: 
TRPA1 (transient receptor potential cation channel, subfamily A, member 1) is a protein-coding gene. Diseases associated with TRPA1 include dentin sensitivity, and somatoform disorder. GO annotations related to this gene include calcium channel activity and channel activity. An important paralog of this gene is TNKS2.

UniProtKB/Swiss-Prot: TRPA1_HUMAN, O75762
Function: Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold
perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators
and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears
gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by
delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation.
May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby
participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system
(By similarity)

summary for TRPA1 Gene:
TRPA1 is a member of the transient receptor potential (TRP) superfamily of ion channels. TRPA1 is classed as
a thermoTRP: a TRP channel which is gated by temperature and functions as a temperature transducer. This
channel is thought to be indirectly activated by cold; it is often expressed in the same neurons as TRPV1,
another thermoTRP, which senses heat.

Gene Wiki entry for TRPA1 (Transient receptor potential cation channel, member A1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_008183.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRPA1 gene promoter:
         ER-alpha   HFH-3   Tal-1beta   NF-AT   FOXI1   NF-AT4   NF-AT2   NF-AT3   ITF-2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRPA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRPA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRPA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q13   Ensembl cytogenetic band:  8q13.3   HGNC cytogenetic band: 8q13

TRPA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRPA1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M072983:  view genomic region     (about GC identifiers)

Start:
72,932,152 bp from pter      End:
72,987,852 bp from pter
Size:
55,701 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRPA1_HUMAN, O75762 (See protein sequence)
Recommended Name: Transient receptor potential cation channel subfamily A member 1  
Size: 1119 amino acids; 127501 Da
Subunit: Homotetramer (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein (Probable)
Secondary accessions: A6NIN6

Explore the universe of human proteins at neXtProt for TRPA1: NX_O75762

Explore proteomics data for TRPA1 at MOPED 

Post-translational modifications:

  • UniProtKB: TRPA1 activation by electrophiles occurs though covalent modification of specific cysteine residues in the
    N-terminal cytoplasmic domain (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75762

  • TRPA1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRPA1 Protein Expression
    REFSEQ proteins: NP_015628.2  
    ENSEMBL proteins: 
     ENSP00000428151   ENSP00000262209  

    Human Recombinant Protein Products for TRPA1: 
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    Cloud-Clone Corp. Proteins for TRPA1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS10066796
    GO:0016020membrane ----
    GO:0016021integral to membrane ----
    GO:0032421stereocilium bundle IEA--

    TRPA1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TRP: Voltage-gated ion channels / Transient receptor potential cation channels
    ANKRD: Ankyrin repeat domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: TRPA1 
    Transient Receptor Potential channels

    3 InterPro protein domains:
     IPR020683 Ankyrin_rpt-contain_dom
     IPR005821 Ion_trans_dom
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry O75762

    ProtoNet protein and cluster: O75762

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: TRPA1_HUMAN, O75762
    Similarity: Belongs to the transient receptor (TC 1.A.4) family
    Similarity: Contains 15 ANK repeats


    TRPA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRPA1_HUMAN, O75762
    Function: Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold
    perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators
    and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears
    gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by
    delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation.
    May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby
    participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system
    (By similarity)
    Enzyme regulation: Inhibited by ruthenium red, a potent blocker of TRPV channels (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005262calcium channel activity IEA--
    GO:0005515protein binding ----
    GO:0015267channel activity TAS10066796
         
    TRPA1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for TRPA1:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         9 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Trpa1):
     behavior/neurological  hearing/vestibular/ear  homeostasis/metabolism  immune system  integument 
     nervous system  normal  respiratory system  taste/olfaction 

    TRPA1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TRPA1: Trpa1tm2.1Kykw Trpa1tm1Kykw Trpa1tm1Jul

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRPA1 
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    SwitchGear 3'UTR luciferase reporter plasmidTRPA1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TRPA1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Calcium channels
    Calcium channels

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TRPA1
        Calcium channels




    TRPA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRPA1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for TRPA1 (O757623 ENSP000002622094) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYLDQ9NQC73, ENSP000003089284I2D: score=2 STRING: ENSP00000308928
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS10066796
    GO:0006816calcium ion transport ----
    GO:0009409response to cold IEA--
    GO:0042493response to drug IEA--
    GO:0042542response to hydrogen peroxide IEA--

    TRPA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRPA1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for TRPA1

    Compounds for TRPA1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TCS 5861528TRPA1 blocker[332117-28-9]
    AP 18Reversible TRPA1 channel blocker[55224-94-7]
    IcilinActivates a novel cold receptor. Cooling agent[36945-98-9]
    A 967079Selective TRPA1 channel blocker[1170613-55-4]
    HC 030031Selective TRPA1 blocker[349085-38-7]

    1 HMDB Compound for TRPA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Menthol(-)-(1R,3R,4S)-Menthol (see all 21)2216-51-5--

    1 DrugBank Compound for TRPA1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Menthol(-)-menthol (see all 5)2216-51-5targetinducer12654248 11752352 15931068 16829128

    10/39 IUPHAR Ligands for TRPA1 (TRPA1) (see all 39)    About this table 
    LigandTypeActionAffinityPubmed IDs
    PF-4840154
    ActivatorActivation7.621741838
    SC-51089
    ActivatorActivation7.218501939
    A-967079
    Gating inhibitorInhibition7.221402443
    1'-acetoxychavicol acetate
    ActivatorActivation6.820699565
    chloropicrin
    ActivatorActivation6.719036859
    omega-chloroacetophenone
    ActivatorActivation6.618501939
    NPPB
    ActivatorActivation6.4920226176
    benzoquinone
    ActivatorActivation6.422109525
    isovelleral
    ActivatorActivation6.318550530
    bromoacetone
    ActivatorActivation619036859

    2 Novoseek inferred chemical compound relationships for TRPA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    allyl isothiocyanate 87 3 19171673 (1), 19220220 (1), 19888597 (1)
    capsaicin 76.9 4 19171673 (2), 19074743 (1), 19939193 (1)

    Search CenterWatch for drugs/clinical trials and news about TRPA1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRPA1 gene: 
    NM_007332.2  

    Unigene Cluster for TRPA1:

    Transient receptor potential cation channel, subfamily A, member 1
    Hs.716816  [show with all ESTs]
    Unigene Representative Sequence: Y10601
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000523582 ENST00000262209(uc003xza.3) ENST00000520596 ENST00000519720
    ENST00000522271 ENST00000520788
    miRNA
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    Additional mRNA sequence: 

    AK307942.1 Y10601.1 

    4 DOTS entries:

    DT.75133838  DT.120629561  DT.75149037  DT.99994718 

    17 AceView cDNA sequences:

    AA972567 AI340031 Y10601 AI879472 BX479572 BE348330 AA502609 NM_007332 
    BF438124 BX482652 BG185430 BX504580 BX472444 BE153179 BE153109 BF570694 
    BE153213 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRPA1 expression in normal human tissues (normalized intensities)      TRPA1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGAAATATTT
    TRPA1 Expression
    About this image


    TRPA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Endoderm progenitor-like cells ( Generation and expansion of endodermal progenitor...
     
     Primitive Streak (Early Embryonic Tissues)
             Definitive endoderm-like cells ( Generation and expansion of endodermal progenitor...
     
     Endothelium (Cardiovascular System)
             CD31, CD144 positive cells ( Two-step protocol for endothelial differentiation by...
     
     Inner Cell Mass (Early Embryonic Tissues)
             Line H9 (WA09)
     
     Brain (Nervous System)
             ganglion/cranial/glossopharyngeal IX   

    See TRPA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRPA1

    SOURCE GeneReport for Unigene cluster: Hs.716816

    UniProtKB/Swiss-Prot: TRPA1_HUMAN, O75762
    Tissue specificity: Expressed at very low level. Expressed at very low level in human fibroblasts and at a
    moderate level in liposarcoma cells

        SABiosciences Expression via Pathway-Focused PCR Array including TRPA1: 
              Neuronal Ion Channels in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TRPA1 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trpa11 , 5 transient receptor potential cation channel, subfamily more1, 5 81.06(n)1
    80.43(a)1
      1 (4.50 cM)5
    2773281  NM_177781.41  NP_808449.11 
     148726485 
    chicken
    (Gallus gallus)
    Aves TRPA11 transient receptor potential cation channel, subfamily more 68.08(n)
    63.08(a)
      420180  XM_418294.3  XP_418294.3 
    lizard
    (Anolis carolinensis)
    Reptilia TRPA16
    transient receptor potential cation channel, subfa...
    57(a)
    1 ↔ 1
    4(33024280-33063118)
    zebrafish
    (Danio rerio)
    Actinopterygii trpa1a1 transient receptor potential cation channel, subfamily more 55.32(n)
    50.05(a)
      474351  NM_001007065.1  NP_001007066.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta TrpA11 Transient receptor potential A1 47.14(n)
    38.69(a)
      39015  NM_140006.4  NP_648263.4 
    worm
    (Caenorhabditis elegans)
    Secernentea trpa-11 Protein TRPA-1 43.22(n)
    29.57(a)
      178118  NM_069848.3  NP_502249.3 


    ENSEMBL Gene Tree for TRPA1 (if available)
    TreeFam Gene Tree for TRPA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRPA1 gene
    TNKS22  ANK32  ANK12  ANKRD522  TNKS2  ANKRD652  ANKRD502  ANKFY12  
    INVS2  ANK22  ANKRD282  
    6 SIMAP similar genes for TRPA1 using alignment to 2 protein entries:     TRPA1_HUMAN (see all proteins):
    NRARP    ANKRD42    GABPB1    RAI14    IkBa    PSMD10

    TRPA1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TRPA1
    PGOHUM00000257192


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/524 SNPs in TRPA1 are shown (see all 524)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0206634
    ----see VAR_0206632 H R mis40--------
    rs1997051861,2
    C--72969144(+) AGATAC/TACATT 1 -- int10--------
    rs617363131,2
    C,F--72969228(+) CAAAAT/ATATCT 2 /N /I mis12Minor allele frequency- A:0.03NS NA 4260
    rs37797521,2
    C,F,A,H--72969263(+) AAAAAA/CCACTA 1 -- int114Minor allele frequency- C:0.14NS EA NA 1932
    rs1437893541,2
    --72969370(+) GTTTAC/TAGGAA 1 -- int10--------
    rs1922389111,2
    --72969430(+) ACTCTC/GTGTGT 1 -- int10--------
    rs1508896481,2
    --72969431(+) CTCTC-/TGTGTGT 1 -- int10--------
    rs1384025751,2
    C--72969517(+) AAGCAC/TAAAAT 1 -- int10--------
    rs1842573711,2
    --72969564(+) GATAGA/CAGAGA 1 -- int10--------
    rs1429221661,2
    --72969573(+) GAAGGA/TCACCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for TRPA1 (72932152 - 72987852 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TRPA1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2737154CNV Deletion23290073
    esv2737155CNV Deletion23290073
    esv2737156CNV Deletion23290073
    esv1942504CNV Deletion18987734
    nsv831353CNV Loss17160897
    esv6851CNV Gain19470904


    Human Gene Mutation Database (HGMD): TRPA1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TRPA1
    DNA2.0 Custom Variant and Variant Library Synthesis for TRPA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604775    OMIM disorders: --

    14 diseases for TRPA1:    About MalaCards
    dentin sensitivity    somatoform disorder    nephronophthisis    neuroma
    paine syndrome    liposarcoma    allergic rhinitis    rhinitis
    neuropathy    neuroblastoma    neuronitis    alcoholism
    hypoxia    melanoma

    2 diseases from the University of Copenhagen DISEASES database for TRPA1:
    Dentin sensitivity     Pain agnosia

    TRPA1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for TRPA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperalgesia 57.8 7 19939193 (2), 18086308 (1)

    Genetic Association Database (GAD): TRPA1
    Human Genome Epidemiology (HuGE) Navigator: TRPA1 (2 documents)

    Export disorders for TRPA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRPA1 gene, integrated from 9 sources (see all 86):
    (articles sorted by number of sources associating them with TRPA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. (PubMed id 16382100)1, 3 Clapham D.E....Schultz G. (2005)
    2. An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts. (PubMed id 10066796)1, 2 Jaquemar D.... Trueb B. (1999)
    3. QGP-1 cells release 5-HT via TRPA1 activation; a mode l of human enterochromaffin cells. (PubMed id 19507004)1, 9 Doihara H....Ito H. (2009)
    4. TRPA1 is a substrate for de-ubiquitination by the tumor suppressor CYLD. (PubMed id 16500080)1, 9 Stokes A....Turner H. (2006)
    5. Differentiation dependent expression of TRPA1 and TRP M8 channels in IMR-32 human neuroblastoma cells. (PubMed id 19507192)1, 9 Louhivuori L.M....Akerman K.E. (2009)
    6. Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. (PubMed id 19074743)1, 9 Bessac B.F. and Jordt S.E. (2008)
    7. TRPA1 and TRPM8 activation in humans: effects of cinnamaldehyde and menthol. (PubMed id 15931068)7, 9 Namer B....Maihofner C. (2005)
    8. Benzoquinone reveals a cysteine-dependent desensitizat ion mechanism of TRPA1. (PubMed id 23478802)1 Ibarra Y. and Blair N.T. (2013)
    9. UV light phototransduction activates transient recepto r potential A1 ion channels in human melanocytes. (PubMed id 23345429)1 Bellono N.W....Oancea E. (2013)
    10. The molecular basis for species-specific activation of human TRPA1 protein by protons involves poorly conserved residues within transm embrane domains 5 and 6. (PubMed id 23709225)1 de la Roche J....Leffler A. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8989 HGNC: 497 AceView: TRPA1 Ensembl:ENSG00000104321 euGenes: HUgn8989
    ECgene: TRPA1 H-InvDB: TRPA1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRPA1 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt082.shtml

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRPA1 gene:
    Search GeneIP for patents involving TRPA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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