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Aliases for TRPA1 Gene

Aliases for TRPA1 Gene

  • Transient Receptor Potential Cation Channel, Subfamily A, Member 1 2 3
  • ANKTM1 3 4 6
  • Ankyrin-Like With Transmembrane Domains 1 2 3
  • Transformation-Sensitive Protein P120 3 4
  • FEPS 3 6
  • Transient Receptor Potential Cation Channel Subfamily A Member 1 3
  • Ankyrin-Like With Transmembrane Domains Protein 1 4

External Ids for TRPA1 Gene

Previous HGNC Symbols for TRPA1 Gene

  • ANKTM1

Previous GeneCards Identifiers for TRPA1 Gene

  • GC08M072983
  • GC08M073096
  • GC08M068428
  • GC08M072932

Summaries for TRPA1 Gene

Entrez Gene Summary for TRPA1 Gene

  • The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRPA1 Gene

TRPA1 (Transient Receptor Potential Cation Channel, Subfamily A, Member 1) is a Protein Coding gene. Diseases associated with TRPA1 include episodic pain syndrome, familial and familial episodic pain syndrome with predominantly upper body involvement. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include calcium channel activity and channel activity. An important paralog of this gene is ANKRD16.

UniProtKB/Swiss-Prot for TRPA1 Gene

  • Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity).

Tocris Summary for TRPA1 Gene

  • TRPA1 is a member of the transient receptor potential (TRP) superfamily of ion channels. TRPA1 is classed as a thermoTRP: a TRP channel which is gated by temperature and functions as a temperature transducer. This channel is thought to be indirectly activated by cold; it is often expressed in the same neurons as TRPV1, another thermoTRP, which senses heat

Gene Wiki entry for TRPA1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRPA1 Gene

Genomics for TRPA1 Gene

Regulatory Elements for TRPA1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRPA1 Gene

Start:
72,019,917 bp from pter
End:
72,075,617 bp from pter
Size:
55,701 bases
Orientation:
Minus strand

Genomic View for TRPA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRPA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRPA1 Gene

Proteins for TRPA1 Gene

  • Protein details for TRPA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75762-TRPA1_HUMAN
    Recommended name:
    Transient receptor potential cation channel subfamily A member 1
    Protein Accession:
    O75762
    Secondary Accessions:
    • A6NIN6

    Protein attributes for TRPA1 Gene

    Size:
    1119 amino acids
    Molecular mass:
    127501 Da
    Quaternary structure:
    • Homotetramer (By similarity). Interacts with TMEM100 (By similarity).

neXtProt entry for TRPA1 Gene

Proteomics data for TRPA1 Gene at MOPED

Post-translational modifications for TRPA1 Gene

  • TRPA1 activation by electrophiles occurs though covalent modification of specific cysteine residues in the N-terminal cytoplasmic domain.
  • Glycosylation at Asn747 and Asn753
  • Modification sites at PhosphoSitePlus

Other Protein References for TRPA1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TRPA1 Gene

Domains for TRPA1 Gene

Gene Families for TRPA1 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing
  • TRP :Voltage-gated ion channels / Transient receptor potential cation channels
IUPHAR :

Protein Domains for TRPA1 Gene

Suggested Antigen Peptide Sequences for TRPA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75762

UniProtKB/Swiss-Prot:

TRPA1_HUMAN :
  • O75762
Family:
  • Belongs to the transient receptor (TC 1.A.4) family.
Similarity:
  • Contains 15 ANK repeats.
genes like me logo Genes that share domains with TRPA1: view

Function for TRPA1 Gene

Molecular function for TRPA1 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by ruthenium red, a potent blocker of TRPV channels.
UniProtKB/Swiss-Prot Function:
Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity).

Gene Ontology (GO) - Molecular Function for TRPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005262 calcium channel activity IEA --
GO:0005515 protein binding --
GO:0015267 channel activity TAS 10066796
genes like me logo Genes that share ontologies with TRPA1: view
genes like me logo Genes that share phenotypes with TRPA1: view

Animal Models for TRPA1 Gene

MGI Knock Outs for TRPA1:

Animal Model Products

miRNA for TRPA1 Gene

miRTarBase miRNAs that target TRPA1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TRPA1 Gene

Localization for TRPA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRPA1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRPA1 Gene COMPARTMENTS Subcellular localization image for TRPA1 gene
Compartment Confidence
plasma membrane 4
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TRPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10066796
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0032421 stereocilium bundle IEA --
genes like me logo Genes that share ontologies with TRPA1: view

Pathways for TRPA1 Gene

genes like me logo Genes that share pathways with TRPA1: view

Pathways by source for TRPA1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TRPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS 10066796
GO:0006816 calcium ion transport --
GO:0009409 response to cold IEA --
GO:0034220 ion transmembrane transport TAS --
GO:0042493 response to drug IEA --
genes like me logo Genes that share ontologies with TRPA1: view

Compounds for TRPA1 Gene

(5) Tocris Compounds for TRPA1 Gene

Compound Action Cas Number
A 967079 Selective TRPA1 channel blocker [1170613-55-4]
AP 18 Reversible TRPA1 channel blocker [55224-94-7]
HC 030031 Selective TRPA1 blocker [349085-38-7]
Icilin Activates a novel cold receptor. Cooling agent [36945-98-9]
Polygodial TRPA1 channel activator; analgesic and antifungal [6754-20-7]

(1) HMDB Compounds for TRPA1 Gene

Compound Synonyms Cas Number PubMed IDs
Menthol
  • (-)-(1R,3R,4S)-Menthol
2216-51-5

(1) Drugbank Compounds for TRPA1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Menthol
  • (-)-menthol
2216-51-5 target inducer

(39) IUPHAR Ligand for TRPA1 Gene

Ligand Type Action Affinity Pubmed IDs
PF-4840154 Activator Activation 7.6
SC-51089 Activator Activation 7.2
A-967079 Gating inhibitor Inhibition 7.2
1-acetoxychavicol acetate Activator Activation 6.8
chloropicrin Activator Activation 6.7
omega-chloroacetophenone Activator Activation 6.6
NPPB Activator Activation 6.49
benzoquinone Activator Activation 6.4
isovelleral Activator Activation 6.3
bromoacetone Activator Activation 6
auranofin Activator Activation 6
methylglyoxal Activator Activation 6
artepillin C Activator Activation 5.74
nitrooleic acid Activator Activation 5.7
oleocanthal Activator Activation 5.6
1,6-hexamethylene diisocyanate Activator Activation 5.6
O3 Activator Activation 5.5
AP18 Channel blocker Inhibition 5.5
acrolein Activator Agonist 5.3
farnesylthiosalicylic acid Activator Activation 5.3
HC030031 Channel blocker Inhibition 5.2
apomorphine Activator Activation 5.1
2-pentenal Activator Agonist 4.9
benzyl bromide Activator Activation 4.9
chembridge-5861528 Gating inhibitor Inhibition 4.8
nicotine Activator Activation 4.7
methyl isocyanate Activator Activation 4.6
dibutyl phthalate Activator Activation 4.6
URB597 Activator Agonist 4.6
menthol Activator None 4.6
acetaldehyde Activator Activation 4.1
formalin Activator Activation 3.7
ruthenium red Channel blocker None
allicin Channel blocker None
Delta9-tetrahydrocannabinol Channel blocker None
thymol Activator Activation
cinnamaldehyde Activator Activation
icilin Activator None
chlorobenzylidene malononitrile Activator Activation

(2) Novoseek inferred chemical compound relationships for TRPA1 Gene

Compound -log(P) Hits PubMed IDs
allyl isothiocyanate 87 3
capsaicin 76.9 4
genes like me logo Genes that share compounds with TRPA1: view

Transcripts for TRPA1 Gene

mRNA/cDNA for TRPA1 Gene

(2) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(3) REFSEQ mRNAs :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRPA1 Gene

Transient receptor potential cation channel, subfamily A, member 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRPA1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRPA1 Gene

No ASD Table

Relevant External Links for TRPA1 Gene

GeneLoc Exon Structure for
TRPA1
ECgene alternative splicing isoforms for
TRPA1

Expression for TRPA1 Gene

mRNA expression in normal human tissues for TRPA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRPA1 Gene

This gene is overexpressed in Bladder (15.7), Colon - Transverse (8.8), Small Intestine - Terminal Ileum (7.4), and Stomach (5.3).

Protein differential expression in normal tissues for TRPA1 Gene

This gene is overexpressed in Urine (50.9) and Platelet (17.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TRPA1 Gene

SOURCE GeneReport for Unigene cluster for TRPA1 Gene Hs.716816

mRNA Expression by UniProt/SwissProt for TRPA1 Gene

O75762-TRPA1_HUMAN
Tissue specificity: Expressed at very low level. Expressed at very low level in human fibroblasts and at a moderate level in liposarcoma cells.
genes like me logo Genes that share expressions with TRPA1: view

Expression partners for TRPA1 Gene

In Situ Assay Products

Orthologs for TRPA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRPA1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRPA1 35
  • 84.04 (n)
  • 81.28 (a)
TRPA1 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRPA1 35
  • 85.94 (n)
  • 83.3 (a)
TRPA1 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trpa1 35
  • 81.06 (n)
  • 80.43 (a)
Trpa1 16
Trpa1 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRPA1 35
  • 99.49 (n)
  • 99.64 (a)
TRPA1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trpa1 35
  • 80.28 (n)
  • 80.34 (a)
oppossum
(Monodelphis domestica)
Mammalia TRPA1 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRPA1 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRPA1 35
  • 67.99 (n)
  • 63.06 (a)
TRPA1 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRPA1 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trpa1 35
  • 60.98 (n)
  • 55.23 (a)
zebrafish
(Danio rerio)
Actinopterygii trpa1a 35
  • 55.3 (n)
  • 50.05 (a)
trpa1a 36
  • 48 (a)
OneToMany
trpa1b 36
  • 46 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004863 35
  • 47.85 (n)
  • 39.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta TrpA1 35
  • 47.01 (n)
  • 38.57 (a)
TrpA1 36
  • 30 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea trpa-1 35
  • 43.78 (n)
  • 30.12 (a)
trpa-1 36
  • 19 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
-- 36
  • 21 (a)
OneToMany
Species with no ortholog for TRPA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRPA1 Gene

ENSEMBL:
Gene Tree for TRPA1 (if available)
TreeFam:
Gene Tree for TRPA1 (if available)

Paralogs for TRPA1 Gene

Paralogs for TRPA1 Gene

Selected SIMAP similar genes for TRPA1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TRPA1 Gene

genes like me logo Genes that share paralogs with TRPA1: view

Variants for TRPA1 Gene

Sequence variations from dbSNP and Humsavar for TRPA1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs920828 -- 72,066,711(-) GTGAA(A/T)CTAGA intron-variant
rs920829 - 72,065,468(-) ATAGC(A/G)AAGCA missense, reference
rs920830 -- 72,065,284(-) CTCCC(C/T)GCTTA intron-variant
rs959424 -- 72,077,318(-) TTCCC(C/T)GCACT upstream-variant-2KB
rs1373296 -- 72,077,555(-) AATCT(A/C)TTTGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRPA1 Gene

Variant ID Type Subtype PubMed ID
esv2737154 CNV Deletion 23290073
nsv831353 CNV Loss 17160897
esv1942504 CNV Deletion 18987734
esv2737155 CNV Deletion 23290073
esv6851 CNV Gain 19470904
esv2737156 CNV Deletion 23290073

Relevant External Links for TRPA1 Gene

HapMap Linkage Disequilibrium report
TRPA1
Human Gene Mutation Database (HGMD)
TRPA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRPA1 Gene

Disorders for TRPA1 Gene

(1) OMIM Diseases for TRPA1 Gene (604775)

UniProtKB/Swiss-Prot

TRPA1_HUMAN
  • Episodic pain syndrome, familial, 1 (FEPS1) [MIM:615040]: An autosomal dominant neurologic disorder characterized by onset in infancy of episodic debilitating upper body pain triggered by fasting, cold, and physical stress. The period of intense pain is accompanied by breathing difficulties, tachycardia, sweating, generalized pallor, peribuccal cyanosis, and stiffness of the abdominal wall. Affected individuals do not manifest altered pain sensitivity outside the episodes. {ECO:0000269 PubMed:20547126}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for TRPA1 Gene

(1) Novoseek inferred disease relationships for TRPA1 Gene

Disease -log(P) Hits PubMed IDs
hyperalgesia 57.8 3

Relevant External Links for TRPA1

Genetic Association Database (GAD)
TRPA1
Human Genome Epidemiology (HuGE) Navigator
TRPA1
genes like me logo Genes that share disorders with TRPA1: view

No data available for Genatlas for TRPA1 Gene

Publications for TRPA1 Gene

  1. TRPA1 is a substrate for de-ubiquitination by the tumor suppressor CYLD. (PMID: 16500080) Stokes A. … Turner H. (Cell. Signal. 2006) 3 23
  2. QGP-1 cells release 5-HT via TRPA1 activation; a model of human enterochromaffin cells. (PMID: 19507004) Doihara H. … Ito H. (Mol. Cell. Biochem. 2009) 3 23
  3. Differentiation dependent expression of TRPA1 and TRPM8 channels in IMR-32 human neuroblastoma cells. (PMID: 19507192) Louhivuori L.M. … Akerman K.E. (J. Cell. Physiol. 2009) 3 23
  4. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. (PMID: 16382100) Clapham D.E. … Schultz G. (Pharmacol. Rev. 2005) 2 3
  5. A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome. (PMID: 20547126) Kremeyer B. … Ruiz-Linares A. (Neuron 2010) 3 4

Products for TRPA1 Gene

Sources for TRPA1 Gene

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