Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRPA1 Gene

protein-coding   GIFtS: 61
GCID: GC08M072983

transient receptor potential cation channel, subfamily A,...

(Previous name: ankyrin-like with transmembrane domains 1 )
(Previous symbol: ANKTM1)
 Explore 12 diseases affiliated with
TRPA1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TRPA1    

Aliases
for TRPA1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Transient Receptor Potential Cation Channel, Subfamily A, Member 11 2     Transformation-Sensitive Protein P1202 3
ANKTM11 2 3 5     FEPS2
Ankyrin-Like With Transmembrane Domains 11 2     Transient Receptor Potential Cation Channel Subfamily A Member 12
Ankyrin-Like With Transmembrane Domains Protein 12 3     

External Ids:    HGNC: 4971   Entrez Gene: 89892   Ensembl: ENSG000001043217   OMIM: 6047755   UniProtKB: O757623   

Export aliases for TRPA1 gene to outside databases

Previous GC identifers: GC08M073096 GC08M068428


Summaries
for TRPA1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TRPA1:
The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane
proteins. The specific function of this protein has not yet been determined; however, studies indicate the function
may involve a role in signal transduction and growth control. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TRPA1_HUMAN, O75762
Function: Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold
perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to
a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and
vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by
delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May
be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the
perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity)

summary for TRPA1:
TRPA1 is a member of the transient receptor potential (TRP) superfamily of ion channels. TRPA1 is classed as
a thermoTRP: a TRP channel which is gated by temperature and functions as a temperature transducer. This
channel is thought to be indirectly activated by cold; it is often expressed in the same neurons as TRPV1,
another thermoTRP, which senses heat. TRPA1 is sensitive to numerous chemical irritants including
cinnamaldehyde, allicin and eugenol. The receptor has been linked to nociceptive transduction and neurogenic
inflammation.

Gene Wiki entry for TRPA1 (Transient receptor potential cation channel, member A1)


Genomic Views
for TRPA1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008183.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRPA1 gene promoter:
         ER-alpha   HFH-3   Tal-1beta   NF-AT   FOXI1   NF-AT4   NF-AT2   NF-AT3   ITF-2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRPA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRPA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRPA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q13   Ensembl cytogenetic band:  8q13.3   HGNC cytogenetic band: 8q13

TRPA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRPA1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M072983:  view genomic region     (about GC identifiers)

Start:
 72,932,152 bp from pter      End:
 72,987,852 bp from pter
Size:
 55,701 bases      Orientation:
 minus strand

Proteins
for TRPA1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TRPA1_HUMAN, O75762 (See protein sequence)
Recommended Name: Transient receptor potential cation channel subfamily A member 1  
Size: 1119 amino acids; 127501 Da
Subunit: Homotetramer (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein (Probable)
Secondary accessions: A6NIN6

Explore the universe of human proteins at neXtProt for TRPA1: NX_O75762

Post-translational modifications:

  • TRPA1 activation by electrophiles occurs though covalent modification of specific cysteine residues in the N-terminal
    • cytoplasmic domain (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75762

    • TRPA1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_015628.2  
    ENSEMBL proteins: 
     ENSP00000428151   ENSP00000262209  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for TRPA1 
    GenScript Custom Purified and Recombinant Proteins Services for TRPA1
    Novus Biologicals TRPA1 Proteins
    Novus Biologicals TRPA1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TRPA1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS10066796
    GO:0016021integral to membrane ----
    GO:0032421stereocilium bundle IEA--


    TRPA1 for ontologies           About GeneDecksing



    TRPA1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: TRPA1
    OriGene Custom Antibody Services for TRPA1 
    GenScript Custom Superior Antibodies Services for TRPA1
    Novus Biologicals TRPA1 Antibodies
    Search for Antibodies for TRPA1 at Abcam  
    Uscn Antibodies for TRPA1
    ThermoFisher Antibody for TRPA1

    Assay Products for TRPA1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRPA1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TRPA1

    Protein Domains /
    Families
    for TRPA1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TRPA1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR020683 Ankyrin_rpt-contain_dom
     IPR005821 Ion_trans_dom
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry O75762

    ProtoNet protein and cluster: O75762

    1 Blocks protein family: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: TRPA1_HUMAN, O75762
    Similarity: Belongs to the transient receptor (TC 1.A.4) family
    Similarity: Contains 15 ANK repeats


    Function
    for TRPA1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TRPA1_HUMAN, O75762
    Function: Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold
    perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to
    a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and
    vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by
    delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May
    be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the
    perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity)
    Enzyme regulation: Inhibited by ruthenium red, a potent blocker of TRPV channels (By similarity)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: TRPA1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRPA1
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate TRPA1 (see all 12):
    hsa-miR-30c hsa-miR-3671 hsa-miR-30d hsa-miR-3133 hsa-miR-30a hsa-miR-873 hsa-miR-633 hsa-miR-489
    SwitchGear 3'UTR luciferase reporter plasmid: TRPA1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRPA1 (see all 7)
    OriGene shRNA RFP: TRPA1
    OriGene siRNA: TRPA1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRPA1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TRPA1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRPA1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRPA1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TRPA1 (NM_007332)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRPA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPA1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for TRPA1
    Search LifeMap BioReagents cell lines for TRPA1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPA1

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005262calcium channel activity IEA--
    GO:0015267channel activity TAS10066796


    TRPA1 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for TRPA1:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

    Animal Models:
         Mouse knock-outs for TRPA1: Trpa1tm2.1Kykw Trpa1tm1Kykw Trpa1tm1Jul
         9 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Trpa1):
     behavior/neurological  hearing/vestibular/ear  homeostasis/metabolism  immune system  integument 
     nervous system  normal  respiratory system  taste/olfaction 

    TRPA1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TRPA1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Calcium channels
    		Calcium channels1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for TRPA1
        Calcium channels




    TRPA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRPA1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for TRPA1 (O757623 ENSP000002622094) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYLDQ9NQC73, ENSP000003089284I2D: score=2 STRING: ENSP00000308928
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS10066796
    GO:0006816calcium ion transport ----
    GO:0009409response to cold IEA--
    GO:0042493response to drug IEA--
    GO:0042542response to hydrogen peroxide IEA--


    TRPA1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TRPA1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRPA1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for TRPA1

    Compounds for TRPA1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AP 18Reversible TRPA1 channel blocker[55224-94-7]
    IcilinActivates a novel cold receptor. Cooling agent[36945-98-9]
    2-APBIP3 receptor antagonist. Also TRP channel modulator[524-95-8]
    PolygodialTRPA1 channel activator; analgesic and antifungal[6754-20-7]
    HC 030031Selective TRPA1 blocker[349085-38-7]

    1 HMDB Compound for TRPA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Menthol(-)-(1R,3R,4S)-Menthol (see all 21)2216-51-5--

    1 DrugBank Compound for TRPA1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Menthol(-)-menthol (see all 5)2216-51-5targetinducer12654248 11752352 15931068 16829128

    2 Novoseek chemical compound relationships for TRPA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    allyl isothiocyanate 87 3 19171673 (1), 19220220 (1), 19888597 (1)
    capsaicin 76.9 4 19171673 (2), 19074743 (1), 19939193 (1)

    Search CenterWatch for drugs/clinical trials and news about TRPA1 

    Transcripts
    for TRPA1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TRPA1 gene: 
    NM_007332.2  

    Unigene Cluster for TRPA1:

    Transient receptor potential cation channel, subfamily A, member 1
    Hs.716816  [show with all ESTs]
    Unigene Representative Sequence: Y10601
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000523582 ENST00000262209(uc003xza.3) ENST00000520596 ENST00000519720
    ENST00000522271 ENST00000520788

    miRNA
    Products:             		 OriGene 3'-UTR Clone: TRPA1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRPA1
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate TRPA1 (see all 12):
    hsa-miR-30c hsa-miR-3671 hsa-miR-30d hsa-miR-3133 hsa-miR-30a hsa-miR-873 hsa-miR-633 hsa-miR-489
    SwitchGear 3'UTR luciferase reporter plasmid: TRPA1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRPA1 (see all 7)
    OriGene shRNA RFP: TRPA1
    OriGene siRNA: TRPA1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRPA1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRPA1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRPA1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TRPA1 (NM_007332)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRPA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPA1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRPA1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRPA1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRPA1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRPA1

    Additional cDNA sequence: 

    AK307942.1 Y10601.1 

    4 DOTS entries:

    DT.75133838  DT.120629561  DT.75149037  DT.99994718 

    17 AceView cDNA sequences:

    AA972567 BF438124 AA502609 BE348330 AI340031 Y10601 AI879472 BX479572 
    NM_007332 BX482652 BX504580 BG185430 BX472444 BE153179 BF570694 BE153109 
    BE153213 

    GeneLoc Exon Structure


    Expression
    for TRPA1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRPA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CGAAATATTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TRPA1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    Endoderm progenitor-like cells (Generation and expan...)
    Definitive endoderm-like cells (Generation and expan...)
    Definitive endoderm-like cells (A scalable, suspensi...)
    Definitive Endoderm (Generation of beta c...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TRPA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRPA1

    SOURCE GeneReport for Unigene cluster: Hs.716816

    UniProtKB/Swiss-Prot: TRPA1_HUMAN, O75762
    Tissue specificity: Expressed at very low level. Expressed at very low level in human fibroblasts and at a moderate
    level in liposarcoma cells

        SABiosciences Expression via Pathway-Focused PCR Array including TRPA1: 
              Neuronal Ion Channels in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRPA1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRPA1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRPA1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRPA1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPA1

    Orthologs
    for TRPA1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TRPA1 gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Trpa11 , 5 transient receptor potential cation channel, subfamily more1, 5 81.06(n)1
    80.43(a)1    		   1 (4.50 cM)5
    2773281  NM_177781.41  NP_808449.11 
     148726485 
    chicken
    (Gallus gallus)    		 Aves TRPA11 transient receptor potential cation channel, subfamily more 68.08(n)
    63.08(a)    		   420180  XM_418294.3  XP_418294.3 
    lizard
    (Anolis carolinensis)    		 Reptilia TRPA16
    		 --
    		 62(a)
    		 1 ↔ 1
    		 4(33024928-33062695)
    zebrafish
    (Danio rerio)    		 Actinopterygii trpa1a1 transient receptor potential cation channel, subfamily more 55.32(n)
    50.05(a)    		   474351  NM_001007065.1  NP_001007066.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta TrpA11 Transient receptor potential A1 47.14(n)
    38.69(a)    		   39015  NM_140006.4  NP_648263.4 
    worm
    (Caenorhabditis elegans)    		 Secernentea trpa-11 Protein TRPA-1 43.22(n)
    29.57(a)    		   178118  NM_069848.3  NP_502249.3 


    ENSEMBL Gene Tree for TRPA1 (if available)
    TreeFam Gene Tree for TRPA1 (if available) 

    Paralogs
    for TRPA1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRPA1 gene
    ANKFY12  
    7 SIMAP similar genes for TRPA1 using alignment to 2 protein entries:     TRPA1_HUMAN (see all proteins):
    NRARP    ANKRD42    GABPB1    RAI14    IkBa    PSMD10
    HACE1

    TRPA1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TRPA1
    PGOHUM00000257192


    Genomic Variants
    for TRPA1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1098 NCBI SNPs in TRPA1 are shown (see all 1098)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs351857801,2
    		F--72932996(+) GTTAAG/CAGGAT 3 -- ds5001 int12Minor allele frequency- C:0.50NA 4
    rs1839412411,2
    		--72933044(+) TTTAGA/GTGGGT 3 -- ds5001 int10--------
    rs1427702471,2
    		--72933177(+) GGTTTG/TTTTCT 3 -- int1 ds50010--------
    rs1876536931,2
    		--72933397(+) GTTCTA/GTGTTT 3 -- ds5001 int10--------
    rs1473822561,2
    		--72933515(+) TATTTC/TGCATG 3 -- ut31 int10--------
    rs69964131,2
    		C,F,A,H,--72933521(+) GCATGA/GCAGGC 3 -- ut31 int120Minor allele frequency- G:0.21NS EA NA WA CSA 2123
    rs1395291351,2
    		--72933526(+) ACAGGC/TATGGT 3 -- int1 ut310--------
    rs1169838001,2
    		C,F,--72933546(+) CTCACA/GTTCTT 3 -- ut31 int11Minor allele frequency- G:0.02EA 120
    rs69967231,2
    		C,F,A,H,--72933632(+) GACCCC/TTTGTC 3 -- int1 ut31 ese323Minor allele frequency- T:0.28NS EA NA WA CSA 2266
    rs1436405221,2
    		--72933654(+) GAGATC/GTTTGG 3 -- ut31 int10--------

    HapMap Linkage Disequilibrium report for TRPA1 (72932152 - 72987852 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for TRPA1
         1 Indel: 60712
    Human Gene Mutation Database (HGMD): TRPA1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRPA1
    DNA2.0 Custom Variant and Variant Library Synthesis for TRPA1

    Disorders / Diseases
    for TRPA1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TRPA1 for disorders           About GeneDecksing

    OMIM gene information: 604775    OMIM disorders: --

    12 diseases for TRPA1:    About MalaCards
    dentin sensitivity    somatoform disorder    allergic rhinitis    nephronophthisis
    neuronitis    paine syndrome    rhinitis    neuroma
    liposarcoma    neuropathy    neuroblastoma    malaria

    1 disease from the University of Copenhagen DISEASES database for TRPA1:
    Dentin sensitivity

    1 Novoseek disease relationship for TRPA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperalgesia 57.8 7 19939193 (2), 18086308 (1)

    Human Genome Epidemiology (HuGE) Navigator: TRPA1 (2 documents)

    Export disorders for TRPA1 gene to outside databases

    Publications
    for TRPA1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRPA1 gene, integrated from 9 sources (see all 74):
    (articles sorted by number of sources associating them with TRPA1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. (PubMed id 16382100)1, 3 Clapham D.E....Schultz G. (2005)
    2. An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts. (PubMed id 10066796)1, 2 Jaquemar D.... Trueb B. (1999)
    3. QGP-1 cells release 5-HT via TRPA1 activation; a mode l of human enterochromaffin cells. (PubMed id 19507004)1, 9 Doihara H....Ito H. (2009)
    4. TRPA1 is a substrate for de-ubiquitination by the tumor suppressor CYLD. (PubMed id 16500080)1, 9 Stokes A....Turner H. (2006)
    5. Differentiation dependent expression of TRPA1 and TRP M8 channels in IMR-32 human neuroblastoma cells. (PubMed id 19507192)1, 9 Louhivuori L.M....Akerman K.E. (2009)
    6. Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. (PubMed id 19074743)1, 9 Bessac B.F. and Jordt S.E. (2008)
    7. TRPA1 and TRPM8 activation in humans: effects of cinnamaldehyde and menthol. (PubMed id 15931068)7, 9 Namer B....Maihofner C. (2005)
    8. Transient receptor potential ankyrin 1 channel localiz ed to non-neuronal airway cells promotes non-neurogenic inflammation. (PubMed id 22905134)1 Nassini R....Materazzi S. (2012)
    9. Primary alcohols activate human TRPA1 channel in a car bon chain length-dependent manner. (PubMed id 22222967)1 Komatsu T....Tominaga M. (2012)
    10. Methylglyoxal activates the human transient receptor p otential ankyrin 1 channel. (PubMed id 22863862)1 Ohkawara S....Jinno H. (2012)

    External Searches for TRPA1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TRPA1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8989 HGNC: 497 AceView: TRPA1 Ensembl:ENSG00000104321 euGenes: HUgn8989
    ECgene: TRPA1 H-InvDB: TRPA1

    Other Databases showing TRPA1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TRPA1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRPA1 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt082.shtml

    Intellectual Property
    for TRPA1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TRPA1 gene:
    Search GeneIP for patents involving TRPA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for TRPA1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for TRPA1   OriGene shRNA RFP for TRPA1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRPA1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRPA1  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for TRPA1   OriGene 3'-UTR Clone for TRPA1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRPA1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRPA1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TRPA1   OriGene Custom Protein Services for TRPA1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRPA1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRPA1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRPA1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRPA1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRPA1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRPA1
     GenScript Custom Purified and Recombinant Proteins Services for TRPA1 GenScript cDNA clones with any tag delivered in your preferred vector for TRPA1
     GenScript Custom Assay Services for TRPA1 GenScript Custom Superior Antibodies Services for TRPA1
     GenScript Custom overexpressing Cell Line Services for TRPA1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TRPA1 promoter
     Search Chromatin IP Primers for TRPA1
     RT2 qPCR Primer Assay in human, mouse, rat TRPA1
     GNC Network for TRPA1
     SABiosciences PCR Arrays including human, mouse, rat TRPA1
     Tocris compounds for TRPA1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Drugs for TRPA1
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TRPA1 antibodies
     TRPA1 proteins
     TRPA1 lysates
     Search for Antibodies for TRPA1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for TRPA1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     TRPA1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for TRPA1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRPA1
     SwitchGear 3'UTR luciferase reporter plasmids for TRPA1
     SwitchGear Promoter luciferase reporter plasmids for TRPA1
     ThermoFisher Antibody for TRPA1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRPA1
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      TRPA1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4