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Aliases for TROVE2 Gene

Aliases for TROVE2 Gene

  • TROVE Domain Family, Member 2 2 3
  • Sjoegren Syndrome Type A Antigen 3 4
  • 60 KDa Ribonucleoprotein Ro 3 4
  • RORNP 3 4
  • SSA2 3 4
  • RO60 3 4
  • Sjogren Syndrome Antigen A2 (60kDa, Ribonucleoprotein Autoantigen SS-A/Ro) 2
  • Sjogren Syndrome Antigen A2 (60kD, Ribonucleoprotein Autoantigen SS-A/Ro) 3
  • Gastric Cancer Multi-Drug Resistance Protein 3
  • Sjoegren Syndrome Antigen A2 4
  • TROVE Domain Family Member 2 4
  • Ro 60 KDa Autoantigen 4
  • 60 KDa Ro Protein 4
  • SS-A 4

External Ids for TROVE2 Gene

Previous HGNC Symbols for TROVE2 Gene

  • SSA2

Previous GeneCards Identifiers for TROVE2 Gene

  • GC01P189761
  • GC01P191295
  • GC01P164264

Summaries for TROVE2 Gene

GeneCards Summary for TROVE2 Gene

TROVE2 (TROVE Domain Family, Member 2) is a Protein Coding gene. Diseases associated with TROVE2 include congenital heart block and sjogren's syndrome. Among its related pathways are RNA Polymerase I Promoter Opening. GO annotations related to this gene include RNA binding and U2 snRNA binding.

UniProtKB/Swiss-Prot for TROVE2 Gene

  • RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation.

  • May play roles in cilia formation and/or maintenance.

Gene Wiki entry for TROVE2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TROVE2 Gene

Genomics for TROVE2 Gene

Regulatory Elements for TROVE2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TROVE2 Gene

Chromosome:
1
Start:
193,059,422 bp from pter
End:
193,091,777 bp from pter
Size:
32,356 bases
Orientation:
Plus strand

Genomic View for TROVE2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TROVE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TROVE2 Gene

Proteins for TROVE2 Gene

  • Protein details for TROVE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10155-RO60_HUMAN
    Recommended name:
    60 kDa SS-A/Ro ribonucleoprotein
    Protein Accession:
    P10155
    Secondary Accessions:
    • B2RBB9
    • Q5LJ98
    • Q5LJ99
    • Q5LJA0
    • Q86WL3
    • Q86WL4
    • Q92787
    • Q9H1W6

    Protein attributes for TROVE2 Gene

    Size:
    538 amino acids
    Molecular mass:
    60671 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Found in a complex with PUF60 and Y5 RNA. Interacts with RIP11.
    Miscellaneous:
    • Antibodies against normal cellular SSA2 protein are found in sera from patients with systemic lupus erythematosus (SLE)

    Alternative splice isoforms for TROVE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TROVE2 Gene

Proteomics data for TROVE2 Gene at MOPED

Post-translational modifications for TROVE2 Gene

  • Ubiquitination at Lys 224, Lys 227, Lys 342, and Lys 359
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for TROVE2 Gene

Domains & Families for TROVE2 Gene

Protein Domains for TROVE2 Gene

Suggested Antigen Peptide Sequences for TROVE2 Gene

Graphical View of Domain Structure for InterPro Entry

P10155

UniProtKB/Swiss-Prot:

RO60_HUMAN :
  • The horseshoe-shaped TROVE domain is built with 7 helical HEAT-like repeats, and is closed by the VWFA-like domain giving rise to a ring-shaped monomer. Single-stranded RNA is bound in the positively charged central cavity (By similarity).
  • Belongs to the Ro 60 kDa family.
Domain:
  • The horseshoe-shaped TROVE domain is built with 7 helical HEAT-like repeats, and is closed by the VWFA-like domain giving rise to a ring-shaped monomer. Single-stranded RNA is bound in the positively charged central cavity (By similarity).
  • The MIDAS-like motif in the VWFA-like domain binds divalent metal cations.
  • Contains 1 TROVE domain.
Family:
  • Belongs to the Ro 60 kDa family.
genes like me logo Genes that share domains with TROVE2: view

No data available for Gene Families for TROVE2 Gene

Function for TROVE2 Gene

Molecular function for TROVE2 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation.
UniProtKB/Swiss-Prot Function:
May play roles in cilia formation and/or maintenance.

Gene Ontology (GO) - Molecular Function for TROVE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 3200833
GO:0030620 U2 snRNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TROVE2: view
genes like me logo Genes that share phenotypes with TROVE2: view

Animal Models for TROVE2 Gene

MGI Knock Outs for TROVE2:

miRNA for TROVE2 Gene

miRTarBase miRNAs that target TROVE2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TROVE2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TROVE2 Gene

Localization for TROVE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TROVE2 Gene

Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TROVE2 Gene COMPARTMENTS Subcellular localization image for TROVE2 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for TROVE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0030529 ribonucleoprotein complex IDA 17289661
genes like me logo Genes that share ontologies with TROVE2: view

Pathways & Interactions for TROVE2 Gene

SuperPathways for TROVE2 Gene

genes like me logo Genes that share pathways with TROVE2: view

Pathways by source for TROVE2 Gene

1 KEGG pathway for TROVE2 Gene

Gene Ontology (GO) - Biological Process for TROVE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002520 immune system development IEA --
GO:0006383 transcription from RNA polymerase III promoter TAS 3200833
GO:0007224 smoothened signaling pathway IEA --
GO:0009411 response to UV IEA --
GO:0060271 cilium morphogenesis IEA --
genes like me logo Genes that share ontologies with TROVE2: view

No data available for SIGNOR curated interactions for TROVE2 Gene

Drugs & Compounds for TROVE2 Gene

(1) Drugs for TROVE2 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1404

(1) Additional Compounds for TROVE2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
rRNA
genes like me logo Genes that share compounds with TROVE2: view

Transcripts for TROVE2 Gene

Unigene Clusters for TROVE2 Gene

TROVE domain family, member 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TROVE2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TROVE2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12
SP1: - - - - -
SP2: - - - -
SP3: -
SP4: - - - - - - -
SP5:
SP6: - - - - - - -
SP7: - - -

Relevant External Links for TROVE2 Gene

GeneLoc Exon Structure for
TROVE2
ECgene alternative splicing isoforms for
TROVE2

Expression for TROVE2 Gene

mRNA expression in normal human tissues for TROVE2 Gene

Protein differential expression in normal tissues from HIPED for TROVE2 Gene

This gene is overexpressed in Lymph node (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TROVE2 Gene



SOURCE GeneReport for Unigene cluster for TROVE2 Gene Hs.288178

genes like me logo Genes that share expression patterns with TROVE2: view

Protein tissue co-expression partners for TROVE2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TROVE2 Gene

Orthologs for TROVE2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TROVE2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TROVE2 35
  • 92.13 (n)
  • 95.72 (a)
TROVE2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TROVE2 35
  • 94.8 (n)
  • 97.4 (a)
TROVE2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trove2 35
  • 85.19 (n)
  • 89.78 (a)
Trove2 16
Trove2 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TROVE2 35
  • 99.68 (n)
  • 99.81 (a)
TROVE2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trove2 35
  • 84.57 (n)
  • 89.59 (a)
oppossum
(Monodelphis domestica)
Mammalia TROVE2 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TROVE2 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves TROVE2 35
  • 78.31 (n)
  • 80.86 (a)
TROVE2 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TROVE2 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trove2 35
  • 72 (n)
  • 78.07 (a)
African clawed frog
(Xenopus laevis)
Amphibia ssa2-A 35
zebrafish
(Danio rerio)
Actinopterygii trove2 35
  • 59.49 (n)
  • 55.24 (a)
trove2 36
  • 54 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rop-1 35
  • 49.9 (n)
  • 40.76 (a)
rop-1 36
  • 33 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
OneToMany
-- 36
  • 34 (a)
OneToMany
Species with no ortholog for TROVE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TROVE2 Gene

ENSEMBL:
Gene Tree for TROVE2 (if available)
TreeFam:
Gene Tree for TROVE2 (if available)

Paralogs for TROVE2 Gene

No data available for Paralogs for TROVE2 Gene

Variants for TROVE2 Gene

Sequence variations from dbSNP and Humsavar for TROVE2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs12531 -- 193,084,632(+) GGTTT(C/T)ACCAT reference, synonymous-codon, nc-transcript-variant
rs1042235 -- 193,084,879(+) AAAAA(A/G)AAGGA intron-variant, utr-variant-3-prime, nc-transcript-variant
rs1042243 -- 193,085,262(+) TTTTA(A/C)AAATT intron-variant, utr-variant-3-prime, nc-transcript-variant
rs1238155 -- 193,088,163(-) aaaaa(A/G)gcagg intron-variant, utr-variant-3-prime
rs1890660 -- 193,067,822(-) GTTTA(C/T)GGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TROVE2 Gene

Variant ID Type Subtype PubMed ID
nsv466994 CNV Loss 19166990
esv2550406 CNV Deletion 19546169

Variation tolerance for TROVE2 Gene

Residual Variation Intolerance Score: 16.72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 23.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TROVE2 Gene

HapMap Linkage Disequilibrium report
TROVE2
Human Gene Mutation Database (HGMD)
TROVE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TROVE2 Gene

Disorders for TROVE2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for TROVE2 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
congenital heart block
  • heart block congenital
sjogren's syndrome
  • xerodermosteosis
cutaneous lupus erythematosus
  • lupus erythematosus, cutaneous
third-degree atrioventricular block
  • complete av block
systemic lupus erythematosus
  • lupus nephritis
- elite association

Relevant External Links for TROVE2

Human Genome Epidemiology (HuGE) Navigator
TROVE2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TROVE2
genes like me logo Genes that share disorders with TROVE2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TROVE2 Gene

Publications for TROVE2 Gene

  1. Extraordinary antigenicity of the human Ro52 autoantigen. (PMID: 20407604) Burbelo P.D. … Iadarola M.J. (Am. J. Transl. Res. 2010) 23 67
  2. Anti-idiotype-mediated epitope spreading and diminished phagocytosis by a human monoclonal antibody recognizing late-stage apoptotic cells. (PMID: 16470225) Gandhi R. … Pal R. (Cell Death Differ. 2006) 23 67
  3. Pathophysiology of SjAPgren's syndrome. (PMID: 17045106) GarcA-a-Carrasco M. … Cervera R. (Arch. Med. Res. 2006) 23 67
  4. 52-kDa Ro/SSA epitopes preferentially recognized by antibodies from mothers of children with neonatal lupus and congenital heart block. (PMID: 16356190) Fritsch C. … Muller S. (Arthritis Res. Ther. 2006) 23 67
  5. Retropseudogenes derived from the human Ro/SS-A autoantigen-associated hY RNAs. (PMID: 15817567) Perreault J. … Boire G. (Nucleic Acids Res. 2005) 23 67

Products for TROVE2 Gene

Sources for TROVE2 Gene

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