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TROVE2 Gene

protein-coding   GIFtS: 59
GCID: GC01P193028

TROVE Domain Family, Member 2

(Previous names: Sjogren syndrome antigen A2 (60kDa, ribonucleoprotein autoantigen...)
(Previous symbol: SSA2)
  See TROVE2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TROVE Domain Family, Member 21 2     Gastric Cancer Multi-Drug Resistance Protein2
SSA21 2 3 5     Sjogren Syndrome Antigen A2 (60kD, Ribonucleoprotein Autoantigen SS-A/Ro)2
RO602 3 5     60 KDa Ro Protein3
Sjoegren Syndrome Type A Antigen2 3     RoRNP3
60 KDa Ribonucleoprotein Ro2 3     SS-A3
Sjogren Syndrome Antigen A2 (60kDa, Ribonucleoprotein Autoantigen SS-A/Ro)1     Ro 60 KDa Autoantigen3
60 KDa SS-A/Ro Ribonucleoprotein2     Sjoegren Syndrome Antigen A23
RORNP2     TROVE Domain Family Member 23

External Ids:    HGNC: 113131   Entrez Gene: 67382   Ensembl: ENSG000001167477   OMIM: 6000635   UniProtKB: P101553   

Export aliases for TROVE2 gene to outside databases

Previous GC identifers: GC01P189761 GC01P191295 GC01P164264


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TROVE2 Gene:
TROVE2 (TROVE domain family, member 2) is a protein-coding gene. Diseases associated with TROVE2 include sjogren's syndrome, and congenital heart block. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot: RO60_HUMAN, P10155
Function: RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic
RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation
Function: May play roles in cilia formation and/or maintenance (By similarity)

Gene Wiki entry for TROVE2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TROVE2 gene promoter:
         AP-2beta   IRF-1   AP-2gamma   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTROVE2 promoter sequence
   Search Chromatin IP Primers for TROVE2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TROVE2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31   Ensembl cytogenetic band:  1q31.2   HGNC cytogenetic band: 1q31

TROVE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TROVE2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P193028:  view genomic region     (about GC identifiers)

Start:
193,028,552 bp from pter      End:
193,060,907 bp from pter
Size:
32,356 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RO60_HUMAN, P10155 (See protein sequence)
Recommended Name: 60 kDa SS-A/Ro ribonucleoprotein  
Size: 538 amino acids; 60671 Da
Subunit: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Found in a complex
with PUF60 and Y5 RNA. Interacts with RIP11
Miscellaneous: Antibodies against normal cellular SSA2 protein are found in sera from patients with systemic lupus
erythematosus (SLE)
Secondary accessions: B2RBB9 Q5LJ98 Q5LJ99 Q86WL3 Q86WL4 Q92787 Q9H1W6
Alternative splicing: 4 isoforms:  P10155-1   P10155-2   P10155-3   P10155-4   

Explore the universe of human proteins at neXtProt for TROVE2: NX_P10155

Explore proteomics data for TROVE2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys224, Lys227, Lys342, Lys359
  • Modification sites at PhosphoSitePlus

  • See TROVE2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001035828.1  NP_001035829.2  NP_001166995.1  NP_001166996.1  NP_004591.2  

    ENSEMBL proteins: 
     ENSP00000383752   ENSP00000472298   ENSP00000401176   ENSP00000425296   ENSP00000356416  
     ENSP00000356413   ENSP00000356415   ENSP00000356414   ENSP00000356411   ENSP00000424612  
     ENSP00000411421  

    TROVE2 Human Recombinant Protein Products:

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    Novus Biologicals TROVE2 Proteins
    Novus Biologicals TROVE2 Lysates
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    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TROVE2
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for TROVE2 

     
    antibodies-online proteins for TROVE2 (27 products) 

     
    antibodies-online peptides for TROVE2

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    antibodies-online antibodies for TROVE2 (72 products) 

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
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    antibodies-online kits for TROVE2 (5 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR008858 TROVE
     IPR018698 VWA-like_dom

    Graphical View of Domain Structure for InterPro Entry P10155

    ProtoNet protein and cluster: P10155

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB008858 TROVE


    UniProtKB/Swiss-Prot: RO60_HUMAN, P10155
    Domain: The horseshoe-shaped TROVE domain is built with 7 helical HEAT-like repeats, and is closed by the
    VWFA-like domain giving rise to a ring-shaped monomer. Single-stranded RNA is bound in the positively charged
    central cavity (By similarity)
    Domain: The MIDAS-like motif in the VWFA-like domain binds divalent metal cations (By similarity)
    Similarity: Belongs to the Ro 60 kDa family
    Similarity: Contains 1 TROVE domain


    Find genes that share domains with TROVE2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RO60_HUMAN, P10155
    Function: RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic
    RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation
    Function: May play roles in cilia formation and/or maintenance (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with TROVE2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TROVE2:
     Synthetic lethal with imatinib 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Trove2):
     cellular  hematopoietic system  immune system  integument  mortality/aging 
     renal/urinary system 

    Find genes that share phenotypes with TROVE2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Trove2tm1Woln for TROVE2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TROVE2
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TROVE2

    miRNA
    Products:
        
    miRTarBase miRNAs that target TROVE2:
    hsa-let-7b-5p (MIRT032451), hsa-mir-1 (MIRT024075), hsa-mir-155-5p (MIRT021028), hsa-mir-128-3p (MIRT022066)

    Block miRNA regulation of human, mouse, rat TROVE2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TROVE2 (see all 17):
    hsa-miR-128 hsa-miR-301a hsa-miR-144 hsa-miR-3658 hsa-miR-205* hsa-miR-130b hsa-miR-301b hsa-miR-601
    SwitchGear 3'UTR luciferase reporter plasmidTROVE2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TROVE2

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    GenScript: all cDNA clones in your preferred vector (see all 5): TROVE2 (NM_001042369)
    Sino Biological Human cDNA Clone for TROVE2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TROVE2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TROVE2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TROVE2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TROVE2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RO60_HUMAN, P10155: Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0030529ribonucleoprotein complex IDA17289661

    Find genes that share ontologies with TROVE2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TROVE2 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    Systemic lupus erythematosus0.40


    Find genes that share SuperPaths with TROVE2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for TROVE2):
        Systemic lupus erythematosus

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TROVE2
    Interactions:

        Search GeneGlobe Interaction Network for TROVE2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for TROVE2 (P101551, 3 ENSP000003564114) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PUF60Q9UHX11, 3, ENSP000003220164EBI-1049168,EBI-1053259 I2D: score=2 STRING: ENSP00000322016
    RAB11FIP5Q9BXF63, ENSP000002580984I2D: score=2 STRING: ENSP00000258098
    TRIM21P194743, ENSP000002544364I2D: score=2 STRING: ENSP00000254436
    CIAO1O760713, ENSP000004182874I2D: score=1 STRING: ENSP00000418287
    GABARAPO951663I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006383transcription from RNA polymerase III promoter TAS3200833
    GO:0060271cilium morphogenesis IEA--

    Find genes that share ontologies with TROVE2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TROVE2 (RO60)

    2 Novoseek inferred chemical compound relationships for TROVE2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rrna 28.9 10 11069285 (2), 10546898 (1)
    zinc 0 1 9588745 (1)



    Find genes that share compounds with TROVE2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TROVE2 gene (5 alternative transcripts): 
    NM_001042369.2  NM_001042370.2  NM_001173524.1  NM_001173525.1  NM_004600.5  

    Unigene Cluster for TROVE2:

    TROVE domain family, member 2
    Hs.288178  [show with all ESTs]
    Unigene Representative Sequence: CR936683
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000400968 ENST00000432079(uc001gsu.2) ENST00000469214 ENST00000415442
    ENST00000460715 ENST00000506303 ENST00000367446(uc001gss.3 uc001gsv.2 uc001gsx.2)
    ENST00000367443 ENST00000367445 ENST00000367444 ENST00000367441 ENST00000512587
    ENST00000416058(uc009wyp.3 uc001gsw.3 uc009wyq.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TROVE2 (see all 17):
    hsa-miR-128 hsa-miR-301a hsa-miR-144 hsa-miR-3658 hsa-miR-205* hsa-miR-130b hsa-miR-301b hsa-miR-601
    SwitchGear 3'UTR luciferase reporter plasmidTROVE2 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat TROVE2
      QuantiFast Probe-based Assays in human, mouse, rat TROVE2

    Additional mRNA sequence: 

    AK022030.1 AK130037.1 AK314594.1 AY205314.1 AY205315.1 BC036658.2 CR936683.1 J04137.1 
    M25077.1 NR_033393.1 

    23 DOTS entries:

    DT.75141700  DT.100642014  DT.95240325  DT.92031871  DT.418079  DT.100802792  DT.418078  DT.121333271 
    DT.95144809  DT.121333285  DT.100645365  DT.121333225  DT.121333328  DT.40109812  DT.40244537  DT.40282683 
    DT.91855081  DT.92066219  DT.92425879  DT.95297297  DT.97858161  DT.75187522  DT.95318454 

    Selected AceView cDNA sequences (see all 279):

    AA075182 AA076142 AI925056 BF055104 BE463646 CR607999 AK130037 AI187332 
    CR616562 BG617310 AL538601 AW472859 BM007595 BQ879470 AW162240 AA598811 
    AW117442 AA421921 AI298174 AW511828 BF589718 BI913658 BF431726 AU139166 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TROVE2 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12
    SP1:                                -     -     -     -                                                                       -         
    SP2:                                -     -     -     -                                                                                 
    SP3:                                                  -                                                                                 
    SP4:              -     -     -     -     -     -     -                                                                                 
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for TROVE2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TROVE2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTGCAGGT
    TROVE2 Expression
    About this image

    TROVE2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TROVE2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.288178
        Custom PCR Arrays for TROVE2
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TROVE2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TROVE2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trove21 , 5 TROVE domain family, member 21, 5 85.19(n)1
    89.78(a)1
      1 (62.54 cM)5
    208221  NM_013835.21  NP_038863.11 
     1437507905 
    chicken
    (Gallus gallus)
    Aves TROVE21 TROVE domain family, member 2 78.31(n)
    80.86(a)
      424358  XM_422201.2  XP_422201.1 
    lizard
    (Anolis carolinensis)
    Reptilia TROVE26
    TROVE domain family, member 2
    80(a)
    1 ↔ 1
    GL343267.1(1230078-1240012)
    African clawed frog
    (Xenopus laevis)
    Amphibia ssa2-A2 Sjogren syndrome antigen A2 (60kDa, ribonucleoprotein more 75(n)    L15430.1 
    zebrafish
    (Danio rerio)
    Actinopterygii trove21 TROVE domain family, member 2 59.49(n)
    55.24(a)
      568429  NM_001037397.1  NP_001032474.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rop-11 rop-1 49.9(n)
    40.76(a)
      179425  NM_073237.6  NP_505638.1 


    ENSEMBL Gene Tree for TROVE2 (if available)
    TreeFam Gene Tree for TROVE2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TROVE2 (see all 523)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1821283931,2
    --193031311(+) TGATTA/TTCCAG 6 -- int10--------
    rs786261751,2
    C--193031314(+) TTATCC/GAGGAA 6 -- int11Minor allele frequency- G:0.01NA 120
    rs1499704451,2
    --193031570(+) GCAGAA/GTTAAG 6 -- int10--------
    rs1876613951,2
    --193031598(+) AACTTG/TCCAAA 6 -- int10--------
    rs1915390671,2
    --193031764(+) TTTTCA/GTCACC 6 -- int10--------
    rs1821179491,2
    --193031843(+) CCTTAA/GACTAA 6 -- int10--------
    rs1442439821,2
    --193031853(+) ATGTAC/TTTTTT 6 -- int10--------
    rs1484783721,2
    --193032014(+) TGTCTA/GATAAT 6 -- int10--------
    rs793747141,2
    C,F--193032015(+) GTCTAA/GTAATA 6 -- int11Minor allele frequency- G:0.07WA 118
    rs1453131011,2
    --193032171(+) CTTAGA/GTGTGT 6 -- int10--------

    HapMap Linkage Disequilibrium report for TROVE2 (193028552 - 193060907 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TROVE2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2550406CNV Deletion19546169
    nsv466994CNV Loss19166990

    Human Gene Mutation Database (HGMD): TROVE2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TROVE2
    DNA2.0 Custom Variant and Variant Library Synthesis for TROVE2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600063    OMIM disorders: --

    2 diseases for TROVE2:    
    About MalaCards
    sjogren's syndrome    congenital heart block

    5 diseases from the University of Copenhagen DISEASES database for TROVE2:
    Lupus erythematosus     Congenital heart block     Connective tissue disease     Sjogren's syndrome
    Dermatomyositis

    Find genes that share disorders with TROVE2           About GenesLikeMe

    6 Novoseek inferred disease relationships for TROVE2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sjogrens syndrome 75 7 12410795 (2), 2332496 (1), 8635291 (1), 8871672 (1) (see all 6)
    sjogrens syndrome primary 74 2 8714273 (1), 15314488 (1)
    autoimmune response 69.5 2 8635291 (1), 8871672 (1)
    lupus erythematosus systemic 63.7 4 16356190 (1), 8714273 (1), 12410795 (1), 12410797 (1)
    autoimmune diseases 51.8 6 11903229 (2), 2332496 (1), 15314488 (1), 17045106 (1)
    autoimmunity 28 2 9493142 (1)

    Human Genome Epidemiology (HuGE) Navigator: TROVE2 (1 document)

    Export disorders for TROVE2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TROVE2 gene, integrated from 10 sources (see all 91):
    (articles sorted by number of sources associating them with TROVE2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (Mol. Cell. Proteomics 2007)
    2. Human Y5 RNA specializes a Ro ribonucleoprotein for 5S ribosomal RNA quality control. (PubMed id 18056422)1, 2 Hogg J.R. and Collins K. (Genes Dev. 2007)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Defining a novel 75-kDa phosphoprotein associated with SS-A/Ro and identification of distinct human autoantibodies. (PubMed id 10545525)1, 2 Wang D.... Chan E.K.L. (J. Clin. Invest. 1999)
    6. Mapping of the human 60,000 M(r) Ro/SSA locus: the genes for three Ro/SSA autoantigens are located on separate chromosomes. (PubMed id 8188321)1, 3 Frank M.B. and Mattei M.G. (Immunogenetics 1994)
    7. Isolation and characterization of a cDNA clone encoding the 60-kD component of the human SS-A/Ro ribonucleoprotein autoantigen. (PubMed id 2649513)1, 2 Ben-Chetrit E.... Sulivan K.F. (J. Clin. Invest. 1989)
    8. Molecular analysis of the 60-kDa human Ro ribonucleoprotein. (PubMed id 3200833)1, 2 Deutscher S.L.... Keene J.D. (Proc. Natl. Acad. Sci. U.S.A. 1988)
    9. Analysis of the molecular composition of Ro ribonucleoprotein complexes. Identification of novel Y RNA-binding proteins. (PubMed id 10785401)1, 9 Fabini G....Steiner G. (Eur. J. Biochem. 2000)
    10. Human 60-kDa SS-A/Ro ribonucleoprotein autoantigen gene (SSA2) localized to 1q31 by fluorescence in situ hybridization. (PubMed id 7829096)1, 9 Chan E.K....Matera A.G. (Genomics 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6738 HGNC: 11313 AceView: SSA2 Ensembl:ENSG00000116747 euGenes: HUgn6738
    ECgene: TROVE2 Kegg: 6738 H-InvDB: TROVE2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TROVE2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TROVE2 gene:
    Search GeneIP for patents involving TROVE2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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