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Aliases for TROVE2 Gene

Aliases for TROVE2 Gene

  • TROVE Domain Family Member 2 2 3 4 5
  • Sjoegren Syndrome Type A Antigen 3 4
  • 60 KDa Ribonucleoprotein Ro 3 4
  • RORNP 3 4
  • SSA2 3 4
  • RO60 3 4
  • Sjogren Syndrome Antigen A2 (60kDa, Ribonucleoprotein Autoantigen SS-A/Ro) 2
  • Sjogren Syndrome Antigen A2 (60kD, Ribonucleoprotein Autoantigen SS-A/Ro) 3
  • Gastric Cancer Multi-Drug Resistance Protein 3
  • 60 KDa SS-A/Ro Ribonucleoprotein 3
  • TROVE Domain Family, Member 2 2
  • Sjoegren Syndrome Antigen A2 4
  • Ro 60 KDa Autoantigen 4
  • 60 KDa Ro Protein 4
  • SS-A 4

External Ids for TROVE2 Gene

Previous HGNC Symbols for TROVE2 Gene

  • SSA2

Previous GeneCards Identifiers for TROVE2 Gene

  • GC01P189761
  • GC01P191295
  • GC01P164264

Summaries for TROVE2 Gene

GeneCards Summary for TROVE2 Gene

TROVE2 (TROVE Domain Family Member 2) is a Protein Coding gene. Diseases associated with TROVE2 include Sjogren's Syndrome and Heart Block, Congenital. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include RNA binding and U2 snRNA binding.

UniProtKB/Swiss-Prot for TROVE2 Gene

  • RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation.

  • May play roles in cilia formation and/or maintenance.

Gene Wiki entry for TROVE2 Gene

Additional gene information for TROVE2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TROVE2 Gene

Genomics for TROVE2 Gene

Regulatory Elements for TROVE2 Gene

Enhancers for TROVE2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H192580 1.4 FANTOM5 ENCODE dbSUPER 11.2 -478.8 -478798 0.3 TBL1XR1 RB1 BMI1 RAD21 ZNF207 ATF7 IKZF2 ZNF654 CEBPZ SMAD5 RGS1 LOC647150 TROVE2 CDC73 RGS2 GC01P192596
GH01H192169 1.2 FANTOM5 Ensembl ENCODE 10.5 -889.2 -889221 2.9 PKNOX1 ARNT JUN MAX CHAMP1 ZNF316 NFE2 MAFK DPF2 ZNF354B ENSG00000231767 TROVE2 ZNF101P2 RGS18 LOC105371662
GH01H193007 0.9 ENCODE 10.6 -51.3 -51307 0.3 FOXA2 ATF1 THRB RARA SCRT2 ATF7 CREM THAP11 KAT8 NFIL3 UCHL5 ENSG00000231767 ZNF101P2 SCARNA18B TROVE2
GH01H192967 0.7 ENCODE 11.6 -91.3 -91292 1.7 PKNOX1 TAL1 JUN CEBPG ZNF644 ZNF507 FOXK2 IKZF1 CEBPA HNF4G LOC647150 TROVE2 GC01P192950 ZNF101P2
GH01H192608 1.8 FANTOM5 Ensembl ENCODE dbSUPER 2.2 -450.0 -450029 1.3 PKNOX1 TBL1XR1 RB1 BMI1 BATF RAD21 RFX5 ZNF143 ZNF207 ATF7 RGS1 RGS13 TROVE2 RGS2 GC01P192596 LOC105371664
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TROVE2 on UCSC Golden Path with GeneCards custom track

Promoters for TROVE2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000017490 78 3001 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D ZNF610

Genomic Locations for TROVE2 Gene

Genomic Locations for TROVE2 Gene
chr1:193,059,422-193,091,777
(GRCh38/hg38)
Size:
32,356 bases
Orientation:
Plus strand
chr1:193,028,552-193,060,907
(GRCh37/hg19)

Genomic View for TROVE2 Gene

Genes around TROVE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TROVE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TROVE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TROVE2 Gene

Proteins for TROVE2 Gene

  • Protein details for TROVE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10155-RO60_HUMAN
    Recommended name:
    60 kDa SS-A/Ro ribonucleoprotein
    Protein Accession:
    P10155
    Secondary Accessions:
    • B2RBB9
    • Q5LJ98
    • Q5LJ99
    • Q5LJA0
    • Q86WL3
    • Q86WL4
    • Q92787
    • Q9H1W6

    Protein attributes for TROVE2 Gene

    Size:
    538 amino acids
    Molecular mass:
    60671 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Found in a complex with PUF60 and Y5 RNA. Interacts with RIP11.
    Miscellaneous:
    • Antibodies against normal cellular SSA2 protein are found in sera from patients with systemic lupus erythematosus (SLE).

    Alternative splice isoforms for TROVE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TROVE2 Gene

Post-translational modifications for TROVE2 Gene

  • Ubiquitination at Lys224, posLast=227227, posLast=342342, and Lys359
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TROVE2 Gene

Domains & Families for TROVE2 Gene

Gene Families for TROVE2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TROVE2 Gene

Suggested Antigen Peptide Sequences for TROVE2 Gene

Graphical View of Domain Structure for InterPro Entry

P10155

UniProtKB/Swiss-Prot:

RO60_HUMAN :
  • The horseshoe-shaped TROVE domain is built with 7 helical HEAT-like repeats, and is closed by the VWFA-like domain giving rise to a ring-shaped monomer. Single-stranded RNA is bound in the positively charged central cavity (By similarity).
  • Belongs to the Ro 60 kDa family.
Domain:
  • The horseshoe-shaped TROVE domain is built with 7 helical HEAT-like repeats, and is closed by the VWFA-like domain giving rise to a ring-shaped monomer. Single-stranded RNA is bound in the positively charged central cavity (By similarity).
  • The MIDAS-like motif in the VWFA-like domain binds divalent metal cations.
Family:
  • Belongs to the Ro 60 kDa family.
genes like me logo Genes that share domains with TROVE2: view

Function for TROVE2 Gene

Molecular function for TROVE2 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation.
UniProtKB/Swiss-Prot Function:
May play roles in cilia formation and/or maintenance.

Gene Ontology (GO) - Molecular Function for TROVE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS,IEA 3200833
GO:0030620 U2 snRNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TROVE2: view
genes like me logo Genes that share phenotypes with TROVE2: view

Animal Models for TROVE2 Gene

MGI Knock Outs for TROVE2:

miRNA for TROVE2 Gene

miRTarBase miRNAs that target TROVE2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TROVE2 Gene

Localization for TROVE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TROVE2 Gene

Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TROVE2 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TROVE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0030529 intracellular ribonucleoprotein complex IDA,TAS 17289661
genes like me logo Genes that share ontologies with TROVE2: view

Pathways & Interactions for TROVE2 Gene

genes like me logo Genes that share pathways with TROVE2: view

Pathways by source for TROVE2 Gene

1 KEGG pathway for TROVE2 Gene

Gene Ontology (GO) - Biological Process for TROVE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002520 immune system development IEA --
GO:0006383 transcription from RNA polymerase III promoter TAS 3200833
GO:0007224 smoothened signaling pathway IEA --
GO:0009411 response to UV IEA --
GO:0030030 cell projection organization IEA --
genes like me logo Genes that share ontologies with TROVE2: view

No data available for SIGNOR curated interactions for TROVE2 Gene

Drugs & Compounds for TROVE2 Gene

(1) Drugs for TROVE2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for TROVE2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TROVE2: view

Transcripts for TROVE2 Gene

Unigene Clusters for TROVE2 Gene

TROVE domain family, member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TROVE2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12
SP1: - - - - -
SP2: - - - -
SP3: -
SP4: - - - - - - -
SP5:
SP6: - - - - - - -
SP7: - - -

Relevant External Links for TROVE2 Gene

GeneLoc Exon Structure for
TROVE2
ECgene alternative splicing isoforms for
TROVE2

Expression for TROVE2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TROVE2 Gene

Protein differential expression in normal tissues from HIPED for TROVE2 Gene

This gene is overexpressed in Lymph node (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TROVE2 Gene



Protein tissue co-expression partners for TROVE2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TROVE2 Gene:

TROVE2

SOURCE GeneReport for Unigene cluster for TROVE2 Gene:

Hs.288178

Evidence on tissue expression from TISSUES for TROVE2 Gene

  • Blood(4.5)
  • Nervous system(4.5)
  • Skin(4.3)
  • Spleen(2.5)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with TROVE2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TROVE2 Gene

Orthologs for TROVE2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TROVE2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TROVE2 33 34
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia TROVE2 33 34
  • 94.8 (n)
cow
(Bos Taurus)
Mammalia TROVE2 33 34
  • 92.13 (n)
oppossum
(Monodelphis domestica)
Mammalia TROVE2 34
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TROVE2 34
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trove2 33 16 34
  • 85.19 (n)
rat
(Rattus norvegicus)
Mammalia Trove2 33
  • 84.57 (n)
chicken
(Gallus gallus)
Aves TROVE2 34 33
  • 78.31 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TROVE2 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trove2 33
  • 72 (n)
African clawed frog
(Xenopus laevis)
Amphibia ssa2-A 33
zebrafish
(Danio rerio)
Actinopterygii trove2 33 34
  • 59.49 (n)
worm
(Caenorhabditis elegans)
Secernentea rop-1 33 34
  • 49.9 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
OneToMany
-- 34
  • 26 (a)
OneToMany
Species where no ortholog for TROVE2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TROVE2 Gene

ENSEMBL:
Gene Tree for TROVE2 (if available)
TreeFam:
Gene Tree for TROVE2 (if available)

Paralogs for TROVE2 Gene

No data available for Paralogs for TROVE2 Gene

Variants for TROVE2 Gene

Sequence variations from dbSNP and Humsavar for TROVE2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000020906 -- 193,072,247(+) GATCC(A/G)CCTGC intron-variant
rs1000031152 -- 193,069,901(+) AATGC(C/T)CACCC intron-variant
rs1000245454 -- 193,089,989(+) TTAGT(A/G)GAGAC intron-variant, utr-variant-3-prime
rs1000794759 -- 193,082,411(+) TTTGT(C/T)TTAAT intron-variant
rs1000834910 -- 193,063,202(+) GTTTT(C/G)ATTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TROVE2 Gene

Variant ID Type Subtype PubMed ID
nsv548658 CNV loss 21841781
nsv466994 CNV loss 19166990
esv2550406 CNV deletion 19546169
dgv498n100 CNV loss 25217958

Variation tolerance for TROVE2 Gene

Residual Variation Intolerance Score: 16.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 23.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TROVE2 Gene

Human Gene Mutation Database (HGMD)
TROVE2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TROVE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TROVE2 Gene

Disorders for TROVE2 Gene

MalaCards: The human disease database

(9) MalaCards diseases for TROVE2 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
sjogren's syndrome
  • sicca syndrome
heart block, congenital
  • congenital heart block
lupus erythematosus
  • systemic lupus erythematosus
cutaneous lupus erythematosus
  • lupus erythematosus, cutaneous
systemic lupus erythematosus
  • lupus nephritis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TROVE2

Human Genome Epidemiology (HuGE) Navigator
TROVE2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TROVE2
genes like me logo Genes that share disorders with TROVE2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TROVE2 Gene

Publications for TROVE2 Gene

  1. Molecular composition of IMP1 ribonucleoprotein granules. (PMID: 17289661) Jønson L … Nielsen FC (Molecular & cellular proteomics : MCP 2007) 3 4 60
  2. Human Y5 RNA specializes a Ro ribonucleoprotein for 5S ribosomal RNA quality control. (PMID: 18056422) Hogg JR … Collins K (Genes & development 2007) 3 4 60
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  4. RNA chaperone activity of protein components of human Ro RNPs. (PMID: 15928345) Belisova A … Steiner G (RNA (New York, N.Y.) 2005) 3 22 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for TROVE2 Gene

Sources for TROVE2 Gene

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