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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TROVE2 Gene

protein-coding GIFtS: 59
GCID: GC01P193028

TROVE domain family, member 2

(Previous names: Sjogren syndrome antigen A2 (60kDa, ribonucleoprotein autoantigen...)
(Previous symbol: SSA2)

Explore 12 diseases affiliated with
TROVE2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
TROVE Domain Family, Member 2¹ ²		Gastric Cancer Multi-Drug Resistance Protein²
SSA2¹ ² ³ ⁵		Sjogren Syndrome Antigen A2 (60kD, Ribonucleoprotein Autoantigen SS-A/Ro)²
RO60² ³ ⁵		60 KDa Ro Protein³
Sjoegren Syndrome Type A Antigen² ³		RoRNP³
60 KDa Ribonucleoprotein Ro² ³		SS-A³
Sjogren Syndrome Antigen A2 (60kDa, Ribonucleoprotein Autoantigen SS-A/Ro)¹		Ro 60 KDa Autoantigen³
60 KDa SS-A/Ro Ribonucleoprotein²		Sjoegren Syndrome Antigen A2³
RORNP²		TROVE Domain Family Member 2³

External Ids:	HGNC: 11313¹	Entrez Gene: 6738²	Ensembl: ENSG00000116747⁷	OMIM: 600063⁵	UniProtKB: P10155³

ORGUL members:
	NONCODE:n409232

Export aliases for TROVE2 gene to outside databases

Previous GC identifers: GC01P189761 GC01P191295 GC01P164264

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RO60_HUMAN, P10155

Function: RNA-binding protein that binds to several small cytoplasmic RNA molecules known as Y RNAs. May stabilize

these RNAs from degradation

Function: May play roles in cilia formation and/or maintenance (By similarity)

Gene Wiki entry for TROVE2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TROVE2 gene promoter:
AP-2beta IRF-1 AP-2gamma AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TROVE2 promoter sequence

Search SABiosciences Chromatin IP Primers for TROVE2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TROVE2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31 Ensembl cytogenetic band: 1q31.2 HGNC cytogenetic band: 1q31

TROVE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TROVE2 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P193028: view genomic region (about GC identifiers)

Start:	193,028,552 bp from pter	End:	193,060,907 bp from pter
Size:	32,356 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RO60_HUMAN, P10155 (See protein sequence)

Recommended Name: 60 kDa SS-A/Ro ribonucleoprotein

Size: 538 amino acids; 60671 Da

Subunit: Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1,

HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0,

RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Found in a complex with PUF60 and Y5

RNA. Interacts with RIP11

Subcellular location: Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs

Miscellaneous: Antibodies against normal cellular SSA2 protein are found in sera from patients with systemic lupus

erythematosus (SLE)

Secondary accessions: B2RBB9 Q5LJ98 Q5LJ99 Q86WL3 Q86WL4 Q92787 Q9H1W6

Alternative splicing: 4 isoforms: P10155-1 P10155-2 P10155-3 P10155-4

Explore the universe of human proteins at neXtProt for TROVE2: NX_P10155

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P10155

TROVE2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_001035828.1 NP_001035829.2 NP_001166995.1 NP_001166996.1 NP_004591.2

ENSEMBL proteins:

ENSP00000383752 ENSP00000401176 ENSP00000425296 ENSP00000356416 ENSP00000356413

ENSP00000356415 ENSP00000356414 ENSP00000356411 ENSP00000424612 ENSP00000411421

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals TROVE2 Proteins Novus Biologicals TROVE2 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for TROVE2
	Uscn Proteins for TROVE2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0030529	ribonucleoprotein complex	IDA	17289661

TROVE2 for ontologies About GeneDecksing

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	ThermoFisher Antibody for TROVE2

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	Uscn ELISAs and CLIAs for TROVE2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TROVE2 for domains About GeneDecksing

2 InterPro domains/families:

IPR008858 TROVE

IPR018698 VWA-like_dom

Graphical View of Domain Structure for InterPro Entry P10155

ProtoNet protein and cluster: P10155

2 Blocks protein families:

IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

IPB008858 TROVE

UniProtKB/Swiss-Prot: RO60_HUMAN, P10155

Similarity: Belongs to the Ro 60 kDa family

Similarity: Contains 1 TROVE domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RO60_HUMAN, P10155

Function: RNA-binding protein that binds to several small cytoplasmic RNA molecules known as Y RNAs. May stabilize

these RNAs from degradation

Function: May play roles in cilia formation and/or maintenance (By similarity)

miRNA Products:		OriGene 3'-UTR Clone (see all 3): TROVE2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TROVE2
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate TROVE2 (see all 17):
		hsa-miR-128 hsa-miR-301a hsa-miR-144 hsa-miR-3658 hsa-miR-205* hsa-miR-130b hsa-miR-301b hsa-miR-601

		SwitchGear 3'UTR luciferase reporter plasmid: TROVE2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TROVE2 (see all 7) OriGene shRNA RFP: TROVE2 OriGene siRNA: TROVE2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TROVE2

Gene Editing
Products:

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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TROVE2 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TROVE2 (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): TROVE2 (NM_001042369)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TROVE2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TROVE2
		Search LifeMap BioReagents cell lines for TROVE2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TROVE2

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	IEA	--

TROVE2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for TROVE2:

Synthetic lethal with imatinib

Animal Models:
Mouse knock-out Trove2^tm1Woln for TROVE2
5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Trove2):

cellular

immune system

integument

mortality/aging

renal/urinary system

TROVE2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Systemic lupus erythematosus

Systemic lupus erythematosus

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Kegg Pathway (Kegg details for TROVE2):

Systemic lupus erythematosus

TROVE2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TROVE2

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/19 Interacting proteins for TROVE2 (P10155^{1, 3} ENSP00000356411⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 19)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PUF60	Q9UHX1¹^,³, ENSP00000322016⁴	EBI-1049168,EBI-1053259 I2D: score=2 STRING: ENSP00000322016
RAB11FIP5	Q9BXF6³, ENSP00000258098⁴	I2D: score=2 STRING: ENSP00000258098
TRIM21	P19474³, ENSP00000254436⁴	I2D: score=2 STRING: ENSP00000254436
CIAO1	O76071³, ENSP00000418287⁴	I2D: score=1 STRING: ENSP00000418287
GABARAP	O95166³	I2D: score=2

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006383	transcription from RNA polymerase III promoter	TAS	3200833
GO:0060271	cilium morphogenesis	IEA	--

TROVE2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TROVE2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TROVE2
2 Novoseek chemical compound relationships for TROVE2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rrna	28.9	10	11069285 (2), 10546898 (1)
zinc	0	1	9588745 (1)

Search CenterWatch for drugs/clinical trials and news about TROVE2 / RO60

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TROVE2 gene (5 alternative transcripts):

NM_001042369.2 NM_001042370.2 NM_001173524.1 NM_001173525.1 NM_004600.5

Unigene Cluster for TROVE2:

TROVE domain family, member 2

Hs.288178 [show with all ESTs]

Unigene Representative Sequence: CR936683

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000400968 ENST00000432079(uc001gsu.2) ENST00000469214 ENST00000415442

ENST00000460715 ENST00000506303 ENST00000367446(uc001gss.3 uc001gsv.2 uc001gsx.2)

ENST00000367443 ENST00000367445 ENST00000367444 ENST00000367441 ENST00000512587

ENST00000416058(uc009wyp.3 uc001gsw.3 uc009wyq.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 3): TROVE2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TROVE2
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate TROVE2 (see all 17):
		hsa-miR-128 hsa-miR-301a hsa-miR-144 hsa-miR-3658 hsa-miR-205* hsa-miR-130b hsa-miR-301b hsa-miR-601

		SwitchGear 3'UTR luciferase reporter plasmid: TROVE2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TROVE2 (see all 7) OriGene shRNA RFP: TROVE2 OriGene siRNA: TROVE2
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TROVE2

Additional cDNA sequence:

AK022030.1 AK130037.1 AK314594.1 AY205314.1 AY205315.1 BC036658.2 CR936683.1 J04137.1

M25077.1 NR_033393.1

22 DOTS entries:

DT.75141700 DT.100642014 DT.95240325 DT.92031871 DT.418079 DT.100802792 DT.418078 DT.121333271

DT.95144809 DT.121333285 DT.100645365 DT.121333225 DT.121333328 DT.40109812 DT.40244537 DT.40282683

DT.92066219 DT.92425879 DT.95297297 DT.97858161 DT.75187522 DT.95318454

24/279 AceView cDNA sequences (see all 279):

BF055104 CB267320 AA421921 AA010352 AI985925 AK130037 AI925056 AI968290

CR607999 R24049 BU734973 AA076142 H88460 CF454715 N31697 CB129021

AA970240 AI671460 AL538601 AI089204 BF055556 AA598811 AI652374 BM955936

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TROVE2 (see all 7) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	^	6	^	7a	·	7b	^	8a	·	8b	·	8c	^	9	^	10	^	11a	·	11b	^	12
SP1:											-		-		-		-																								-
SP2:											-		-		-		-
SP3:																	-
SP4:					-		-		-		-		-		-		-
SP5:

ECgene alternative splicing isoforms for TROVE2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TROVE2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGTGCAGGT

About this image
See TROVE2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TROVE2

SOURCE GeneReport for Unigene cluster: Hs.288178

SABiosciences Custom PCR Arrays for TROVE2

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TROVE2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TROVE2 gene from 7/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Trove2^{1 , 5}	TROVE domain family, member 2^{1, 5}	85.19(n)¹ 89.78(a)¹		1 (62.54 cM)⁵ 20822¹ NM_013835.2¹ NP_038863.1¹ 143750790⁵
chicken (Gallus gallus)	Aves	TROVE2¹	TROVE domain family, member 2	78.31(n) 80.86(a)		424358 XM_422201.1 XP_422201.1
lizard (Anolis carolinensis)	Reptilia	TROVE2⁶	--	80(a)	1 ↔ 1	GL343267.1(1230078-1239990)
African clawed frog (Xenopus laevis)	Amphibia	ssa2-A²	Sjogren syndrome antigen A2 (60kDa, ribonucleoprotein more	75(n)		L15430.1
zebrafish (Danio rerio)	Actinopterygii	trove2¹	TROVE domain family, member 2	59.48(n) 55.34(a)		568429 NM_001037397.1 NP_001032474.1
honey bee (Apis mellifera)	Insecta	--	--	28(a)	1 ↔ 1	Group3.25(405073-407157)
worm (Caenorhabditis elegans)	Secernentea	rop-1¹	Protein ROP-1	49.56(n) 40.57(a)		179425 NM_073237.5 NP_505638.1

ENSEMBL Gene Tree for TROVE2 (if available)
TreeFam Gene Tree for TROVE2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs187639929^1,2		--	193026605(+)	`CTAGTC/TTAGCC`	7	--	us2k¹ int¹		0	--	--	--	--
rs146295014^1,2		--	193026804(+)	`ATCTGC/TCCTCA`	7	--	us2k¹ int¹		0	--	--	--	--
rs140612018^1,2		--	193026906(+)	`TACTTG/TAACAT`	7	--	us2k¹ int¹		0	--	--	--	--
rs142214336^1,2		--	193026951(+)	`CCTCCA/GTGACC`	7	--	us2k¹ int¹		0	--	--	--	--
rs140406463^1,2		--	193027078(+)	`ATCCTC/TGGGTG`	11	--	int¹ us2k¹		0	--	--	--	--
rs145202414^1,2		--	193027371(+)	`AAAGAA/TAATTT`	11	--	us2k¹ int¹		0	--	--	--	--
rs147624703^1,2		--	193027476(+)	`ATCTAC/TATCAA`	11	--	us2k¹ int¹		0	--	--	--	--
rs192570806^1,2		--	193027519(+)	`ACATCA/GTAGAG`	11	--	us2k¹ int¹		0	--	--	--	--
rs77701939^1,2	C,F,	--	193027697(+)	`CACTAG/TCTCAA`	11	--	us2k¹ int¹		1		WA	118
rs142042505^1,2		--	193027698(+)	`ACTAGC/GTCAAG`	11	--	us2k¹ int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TROVE2 (193028552 - 193060907 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TROVE2
1 CNV: 97598
Human Gene Mutation Database (HGMD): TROVE2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TROVE2

DNA2.0 Custom Variant and Variant Library Synthesis for TROVE2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TROVE2 for disorders           About GeneDecksing

OMIM gene information: 600063    OMIM disorders: --

12 diseases for TROVE2:    About MalaCards

sjogren's syndrome gastric cancer heart block congenital heart block

lupus erythematosus cutaneous lupus erythematosus systemic lupus erythematosus sialadenitis

dermatomyositis hepatitis b hepatitis fibrosis

5 diseases from the University of Copenhagen DISEASES database for TROVE2:

Systemic lupus erythematosus Congenital heart block Sjogren's syndrome Cutaneous lupus erythematosus

Dermatomyositis

6 Novoseek disease relationships for TROVE2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sjogrens syndrome	75	7	12410795 (2), 2332496 (1), 8635291 (1), 8871672 (1) (see all 6)
sjogrens syndrome primary	74	2	8714273 (1), 15314488 (1)
autoimmune response	69.5	2	8635291 (1), 8871672 (1)
lupus erythematosus systemic	63.7	4	16356190 (1), 8714273 (1), 12410795 (1), 12410797 (1)
autoimmune diseases	51.8	6	11903229 (2), 2332496 (1), 15314488 (1), 17045106 (1)
autoimmunity	28	2	9493142 (1)

Human Genome Epidemiology (HuGE) Navigator: TROVE2 (1 document)

Export disorders for TROVE2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TROVE2 gene, integrated from 9 sources (see all 84):
(articles sorted by number of sources associating them with TROVE2)

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Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)^{1, 2} Joeson L.... Nielsen F.C. (2007)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Defining a novel 75-kDa phosphoprotein associated with SS-A/Ro and identification of distinct human autoantibodies. (PubMed id 10545525)^{1, 2} Wang D.... Chan E.K.L. (1999)
Mapping of the human 60,000 M(r) Ro/SSA locus: the genes for three Ro/SSA autoantigens are located on separate chromosomes. (PubMed id 8188321)^{1, 3} Frank M.B. and Mattei M.G. (1994)
Isolation and characterization of a cDNA clone encoding the 60-kD component of the human SS-A/Ro ribonucleoprotein autoantigen. (PubMed id 2649513)^{1, 2} Ben-Chetrit E.... Sulivan K.F. (1989)
Molecular analysis of the 60-kDa human Ro ribonucleoprotein. (PubMed id 3200833)^{1, 2} Deutscher S.L.... Keene J.D. (1988)
Analysis of the molecular composition of Ro ribonucleoprotein complexes. Identification of novel Y RNA-binding proteins. (PubMed id 10785401)^{1, 9} Fabini G....Steiner G. (2000)
Human 60-kDa SS-A/Ro ribonucleoprotein autoantigen gene (SSA2) localized to 1q31 by fluorescence in situ hybridization. (PubMed id 7829096)^{1, 9} Chan E.K....Matera A.G. (1994)
Interaction cloning and characterization of RoBPI, a novel protein binding to human Ro ribonucleoproteins. (PubMed id 10668799)^{2, 9} Bouffard P.... Boire G. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6738	HGNC: 11313	AceView: SSA2	Ensembl:ENSG00000116747	euGenes: HUgn6738
ECgene: TROVE2	Kegg: 6738	H-InvDB: TROVE2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TROVE2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TROVE2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TROVE2 gene:
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TROVE domain family, member 2

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TROVE domain family, member 2

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