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Aliases for TROAP Gene

Aliases for TROAP Gene

  • Trophinin Associated Protein 2 3 5
  • Tastin 2 3
  • Trophinin-Assisting Protein (Tastin) 3
  • Trophinin-Associated Protein 4
  • Trophinin Assisting Protein 3
  • Trophinin-Assisting Protein 4

External Ids for TROAP Gene

Previous GeneCards Identifiers for TROAP Gene

  • GC12P049599
  • GC12P049748
  • GC12P049434
  • GC12P048003
  • GC12P047964
  • GC12P049716
  • GC12P046747

Summaries for TROAP Gene

GeneCards Summary for TROAP Gene

TROAP (Trophinin Associated Protein) is a Protein Coding gene. Diseases associated with TROAP include Ectopic Pregnancy.

UniProtKB/Swiss-Prot for TROAP Gene

  • Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation.

Gene Wiki entry for TROAP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TROAP Gene

Genomics for TROAP Gene

Regulatory Elements for TROAP Gene

Enhancers for TROAP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F049271 0.8 ENCODE 11.1 -50.5 -50485 0.7 HDGF ZNF211 PKNOX1 ZNF133 CHD7 ZNF316 POLR2A ZBTB48 EED CREM LOC390314 TROAP C1QL4 KANSL2 DDX23 ENSG00000258232 ENSG00000258101
GH12F049293 0.9 ENCODE 4.7 -27.4 -27420 1.4 KLF17 FEZF1 ZNF48 ZNF2 ZNF121 GLIS2 SCRT2 ZNF202 REST ZEB2 DDX23 KANSL2 CCNT1 BCDIN3D LOC390314 LOC101927267 ENSG00000257964 C1QL4 LIMA1 ENSG00000257298
GH12F049321 1.1 ENCODE 0.8 +0.9 922 2.4 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 C1QL4 RPL35AP28 LALBA OR5BS1P OR11M1P ENSG00000258273 H1FNT ENSG00000257253 LOC283332 DNAJC22
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TROAP on UCSC Golden Path with GeneCards custom track

Promoters for TROAP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000243914 862 2001 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for TROAP Gene

Chromosome:
12
Start:
49,322,138 bp from pter
End:
49,331,733 bp from pter
Size:
9,596 bases
Orientation:
Plus strand

Genomic View for TROAP Gene

Genes around TROAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TROAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TROAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TROAP Gene

Proteins for TROAP Gene

  • Protein details for TROAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12815-TROAP_HUMAN
    Recommended name:
    Tastin
    Protein Accession:
    Q12815
    Secondary Accessions:
    • F8VSF9
    • Q6PJU7
    • Q8N5B2

    Protein attributes for TROAP Gene

    Size:
    778 amino acids
    Molecular mass:
    83857 Da
    Quaternary structure:
    • Directly binds bystin, and indirectly trophinin.

    Alternative splice isoforms for TROAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TROAP Gene

Post-translational modifications for TROAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TROAP Gene

Domains & Families for TROAP Gene

Protein Domains for TROAP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TROAP Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TROAP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TROAP Gene

Function for TROAP Gene

Molecular function for TROAP Gene

UniProtKB/Swiss-Prot Function:
Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation.

Gene Ontology (GO) - Molecular Function for TROAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9560222
genes like me logo Genes that share ontologies with TROAP: view
genes like me logo Genes that share phenotypes with TROAP: view

Animal Model Products

miRNA for TROAP Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TROAP Gene

Localization for TROAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for TROAP Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TROAP gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TROAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,TAS --
genes like me logo Genes that share ontologies with TROAP: view

Pathways & Interactions for TROAP Gene

SuperPathways for TROAP Gene

No Data Available

Gene Ontology (GO) - Biological Process for TROAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA,TAS --
genes like me logo Genes that share ontologies with TROAP: view

No data available for Pathways by source and SIGNOR curated interactions for TROAP Gene

Transcripts for TROAP Gene

Unigene Clusters for TROAP Gene

Trophinin associated protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TROAP Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a ·
SP1: - - - - -
SP2: - - - - -
SP3:
SP4: - -
SP5: -
SP6:
SP7:
SP8:
SP9:

ExUns: 17b ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for TROAP Gene

GeneLoc Exon Structure for
TROAP
ECgene alternative splicing isoforms for
TROAP

Expression for TROAP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TROAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TROAP Gene

This gene is overexpressed in Testis (x9.4) and Esophagus - Mucosa (x4.5).

Protein differential expression in normal tissues from HIPED for TROAP Gene

This gene is overexpressed in Heart (61.1) and Ovary (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TROAP Gene



Protein tissue co-expression partners for TROAP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TROAP Gene:

TROAP

SOURCE GeneReport for Unigene cluster for TROAP Gene:

Hs.524399

mRNA Expression by UniProt/SwissProt for TROAP Gene:

Q12815-TROAP_HUMAN
Tissue specificity: Strong expression at implantation sites. Was exclusively localized to the apical side of the syncytiotrophoblast. Also found in macrophages.
genes like me logo Genes that share expression patterns with TROAP: view

Primer Products

Orthologs for TROAP Gene

This gene was present in the common ancestor of mammals.

Orthologs for TROAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TROAP 34 35
  • 99.66 (n)
cow
(Bos Taurus)
Mammalia TROAP 34 35
  • 84.5 (n)
dog
(Canis familiaris)
Mammalia TROAP 34 35
  • 82.41 (n)
mouse
(Mus musculus)
Mammalia Troap 34 16 35
  • 75.17 (n)
rat
(Rattus norvegicus)
Mammalia Troap 34
  • 74.44 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TROAP 35
  • 35 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TROAP 35
  • 34 (a)
OneToOne
Species where no ortholog for TROAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TROAP Gene

ENSEMBL:
Gene Tree for TROAP (if available)
TreeFam:
Gene Tree for TROAP (if available)

Paralogs for TROAP Gene

No data available for Paralogs for TROAP Gene

Variants for TROAP Gene

Sequence variations from dbSNP and Humsavar for TROAP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10400538 -- 49,330,119(+) TGTCA(C/G)ACTGG intron-variant
rs10400567 -- 49,331,937(+) AGCCT(C/T)CCACT downstream-variant-500B
rs111429105 -- 49,322,070(+) TAAGA(A/G)TAACT intron-variant, upstream-variant-2KB
rs111582557 -- 49,324,746(+) TTTTT(-/G)TGGAG intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs11168974 -- 49,320,840(+) ACTCT(A/G)TCTCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TROAP Gene

Variant ID Type Subtype PubMed ID
nsv952175 CNV deletion 24416366
nsv832405 CNV gain 17160897
dgv1497n100 CNV gain 25217958

Variation tolerance for TROAP Gene

Residual Variation Intolerance Score: 80.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.22; 69.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TROAP Gene

Human Gene Mutation Database (HGMD)
TROAP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TROAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TROAP Gene

Disorders for TROAP Gene

MalaCards: The human disease database

(1) MalaCards diseases for TROAP Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ectopic pregnancy
  • eccyesis
- elite association - COSMIC cancer census association via MalaCards
Search TROAP in MalaCards View complete list of genes associated with diseases

Relevant External Links for TROAP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TROAP
genes like me logo Genes that share disorders with TROAP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TROAP Gene

Publications for TROAP Gene

  1. Trophinin and tastin, a novel cell adhesion molecule complex with potential involvement in embryo implantation. (PMID: 7758945) Fukuda M.N. … Nozawa S. (Genes Dev. 1995) 2 3 4 22 64
  2. Tastin is required for bipolar spindle assembly and centrosome integrity during mitosis. (PMID: 18218922) Yang S. … Zhou J. (FASEB J. 2008) 3 22 64
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64
  4. Expression of trophinin, tastin, and bystin by trophoblast and endometrial cells in human placenta. (PMID: 10026108) Suzuki N. … Fukuda M.N. (Biol. Reprod. 1999) 3 22 64
  5. A cytoplasmic protein, bystin, interacts with trophinin, tastin, and cytokeratin and may be involved in trophinin-mediated cell adhesion between trophoblast and endometrial epithelial cells. (PMID: 9560222) Suzuki N. … Fukuda M.N. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 22 64

Products for TROAP Gene

Sources for TROAP Gene

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