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Aliases for TROAP Gene

Aliases for TROAP Gene

  • Trophinin Associated Protein 2 3
  • Trophinin-Associated Protein 3 4
  • Trophinin-Assisting Protein (Tastin) 3
  • Trophinin Assisting Protein 3
  • Trophinin-Assisting Protein 4
  • Tastin 2
  • TASTIN 3

External Ids for TROAP Gene

Previous GeneCards Identifiers for TROAP Gene

  • GC12P049599
  • GC12P049748
  • GC12P049434
  • GC12P048003
  • GC12P047964
  • GC12P049716
  • GC12P046747

Summaries for TROAP Gene

GeneCards Summary for TROAP Gene

TROAP (Trophinin Associated Protein) is a Protein Coding gene. Diseases associated with TROAP include teratocarcinoma and ectopic pregnancy.

UniProtKB/Swiss-Prot for TROAP Gene

  • Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation

Gene Wiki entry for TROAP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TROAP Gene

Genomics for TROAP Gene

Regulatory Elements for TROAP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TROAP Gene

Start:
49,323,188 bp from pter
End:
49,331,731 bp from pter
Size:
8,544 bases
Orientation:
Plus strand

Genomic View for TROAP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TROAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TROAP Gene

Proteins for TROAP Gene

  • Protein details for TROAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12815-TROAP_HUMAN
    Recommended name:
    Tastin
    Protein Accession:
    Q12815
    Secondary Accessions:
    • F8VSF9
    • Q6PJU7
    • Q8N5B2

    Protein attributes for TROAP Gene

    Size:
    778 amino acids
    Molecular mass:
    83857 Da
    Quaternary structure:
    • Directly binds bystin, and indirectly trophinin

    Alternative splice isoforms for TROAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TROAP Gene

Proteomics data for TROAP Gene at MOPED

Post-translational modifications for TROAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TROAP Gene

Domains for TROAP Gene

Protein Domains for TROAP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TROAP Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TROAP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TROAP Gene

Function for TROAP Gene

Molecular function for TROAP Gene

UniProtKB/Swiss-Prot Function:
Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation

Gene Ontology (GO) - Molecular Function for TROAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19060904
genes like me logo Genes that share ontologies with TROAP: view

Phenotypes for TROAP Gene

GenomeRNAi human phenotypes for TROAP:
genes like me logo Genes that share phenotypes with TROAP: view

Animal Model Products

miRNA for TROAP Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TROAP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TROAP Gene

Localization for TROAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for TROAP Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TROAP Gene COMPARTMENTS Subcellular localization image for TROAP gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 2
cytoskeleton 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TROAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TROAP: view

Pathways for TROAP Gene

SuperPathways for TROAP Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Nitric Oxide Signaling Pathway in human,mouse,rat

Gene Ontology (GO) - Biological Process for TROAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with TROAP: view

No data available for Pathways by source for TROAP Gene

Transcripts for TROAP Gene

Unigene Clusters for TROAP Gene

Trophinin associated protein:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TROAP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TROAP Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a ·
SP1: - - - - -
SP2: - - - - -
SP3:
SP4: - -
SP5: -
SP6:
SP7:
SP8:
SP9:

ExUns: 17b ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for TROAP Gene

GeneLoc Exon Structure for
TROAP
ECgene alternative splicing isoforms for
TROAP

Expression for TROAP Gene

mRNA expression in normal human tissues for TROAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TROAP Gene

This gene is overexpressed in Testis (9.4) and Esophagus - Mucosa (4.5).

Protein differential expression in normal tissues for TROAP Gene

This gene is overexpressed in Heart (61.1) and Ovary (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TROAP Gene

SOURCE GeneReport for Unigene cluster for TROAP Gene Hs.524399

mRNA Expression by UniProt/SwissProt for TROAP Gene

Q12815-TROAP_HUMAN
Tissue specificity: Strong expression at implantation sites. Was exclusively localized to the apical side of the syncytiotrophoblast. Also found in macrophages
genes like me logo Genes that share expressions with TROAP: view

Expression partners for TROAP Gene

In Situ Assay Products

Orthologs for TROAP Gene

This gene was present in the common ancestor of mammals.

Orthologs for TROAP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TROAP 35
  • 84.5 (n)
  • 78.34 (a)
TROAP 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TROAP 35
  • 82.41 (n)
  • 75.89 (a)
TROAP 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Troap 35
  • 75.17 (n)
  • 63.36 (a)
Troap 16
Troap 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TROAP 35
  • 99.66 (n)
  • 99.49 (a)
TROAP 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Troap 35
  • 74.44 (n)
  • 63.18 (a)
oppossum
(Monodelphis domestica)
Mammalia TROAP 36
  • 34 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TROAP 36
  • 35 (a)
OneToOne
Species with no ortholog for TROAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TROAP Gene

ENSEMBL:
Gene Tree for TROAP (if available)
TreeFam:
Gene Tree for TROAP (if available)

Paralogs for TROAP Gene

No data available for Paralogs for TROAP Gene

Variants for TROAP Gene

Sequence variations from dbSNP and Humsavar for TROAP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2230549 -- 49,331,642(+) CTGCC(A/G)TACTT utr-variant-3-prime
rs2230550 -- 49,329,010(+) TCACC(C/T)TTTGG reference, synonymous-codon
rs2230551 -- 49,329,217(+) ACACC(C/T)ATGCC reference, synonymous-codon
rs2303614 -- 49,329,102(+) CTGGC(C/G)GGAGA intron-variant
rs3088008 -- 49,331,172(+) GAAGT(A/C)TAGGA intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TROAP Gene

Variant ID Type Subtype PubMed ID
dgv1423n71 CNV Loss 21882294
nsv832405 CNV Gain 17160897

Relevant External Links for TROAP Gene

HapMap Linkage Disequilibrium report
TROAP
Human Gene Mutation Database (HGMD)
TROAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TROAP Gene

Disorders for TROAP Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for TROAP Gene in MalaCards »

(2) Diseases for TROAP Gene including...

(1) Novoseek inferred disease relationships for TROAP Gene

Disease -log(P) Hits PubMed IDs
teratocarcinoma 66.3 1
genes like me logo Genes that share disorders with TROAP: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Genatlas and External Links for TROAP Gene

Publications for TROAP Gene

  1. Trophinin and tastin, a novel cell adhesion molecule complex with potential involvement in embryo implantation. (PMID: 7758945) Fukuda M.N. … Nozawa S. (Genes Dev. 1995) 2 3 4 23
  2. A cytoplasmic protein, bystin, interacts with trophinin, tastin, and cytokeratin and may be involved in trophinin-mediated cell adhesion between trophoblast and endometrial epithelial cells. (PMID: 9560222) Suzuki N. … Fukuda M.N. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 23
  3. Expression of trophinin, tastin, and bystin by trophoblast and endometrial cells in human placenta. (PMID: 10026108) Suzuki N. … Fukuda M.N. (Biol. Reprod. 1999) 3 23
  4. Tastin is required for bipolar spindle assembly and centrosome integrity during mitosis. (PMID: 18218922) Yang S. … Zhou J. (FASEB J. 2008) 3 23
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4

Products for TROAP Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Nitric Oxide Signaling Pathway in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TROAP
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TROAP
    • Block miRNA regulation of TROAP using miScript Target Protectors

    Sources for TROAP Gene

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