Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRNT1 Gene

protein-coding   GIFtS: 57
GCID: GC03P003168

TRNA Nucleotidyl Transferase, CCA-Adding, 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TRNA Nucleotidyl Transferase, CCA-Adding, 11 2     CCA12
Mitochondrial TRNA Nucleotidyl Transferase, CCA-Adding2 3     MtCCA2
Mt CCA-Adding Enzyme2 3     CCA TRNA Nucleotidyltransferase 1, Mitochondrial2
Mt TRNA Adenylyltransferase2 3     Mitochondrial CCA-Adding TRNA-Nucleotidyltransferase2
Mt TRNA CCA-Diphosphorylase2 3     TRNA-Nucleotidyltransferase 1, Mitochondrial2
Mt TRNA CCA-Pyrophosphorylase2 3     EC 2.7.7.723

External Ids:    HGNC: 173411   Entrez Gene: 510952   Ensembl: ENSG000000727567   OMIM: 6129075   UniProtKB: Q96Q113   

Export aliases for TRNT1 gene to outside databases

Previous GC identifers: GC03P003097 GC03P003143 GC03P003102


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRNT1 Gene:
The CCA-adding enzyme TRNT1 (EC 2.7.7.25) is an essential enzyme that catalyzes the addition of the CCA terminus
to the 3-prime end of tRNA precursors. This reaction is a fundamental prerequisite for mature tRNAs to become
aminoacylated and to participate in protein biosynthesis (Lizano et al., 2007 (PubMed 17204286)).(supplied by
OMIM, Aug 2009)

GeneCards Summary for TRNT1 Gene: 
TRNT1 (tRNA nucleotidyl transferase, CCA-adding, 1) is a protein-coding gene. Diseases associated with TRNT1 include pneumonia, and tuberculosis. GO annotations related to this gene include tRNA nucleotidyltransferase activity and tRNA binding.

UniProtKB/Swiss-Prot: TRNT1_HUMAN, Q96Q11
Function: Isoform 1: Adds and repairs the conserved 3'-CCA sequence necessary for the attachment of amino acids to
the 3' terminus of tRNA molecules, using CTP and ATP as substrates
Function: Isoform 2: Adds 2 C residues (CC-) to the 3' terminus of tRNA molecules instead of a complete CCA end as
isoform 1 does (in vitro)

Gene Wiki entry for TRNT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRNT1 gene promoter:
         HFH-3   ISGF-3   Sox5   CUTL1   RelA   FOXL1   AREB6   FOXI1   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRNT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRNT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRNT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.1   Ensembl cytogenetic band:  3p26.2   HGNC cytogenetic band: 3p25.1

TRNT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRNT1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P003168:  view genomic region     (about GC identifiers)

Start:
3,168,600 bp from pter      End:
3,192,563 bp from pter
Size:
23,964 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRNT1_HUMAN, Q96Q11 (See protein sequence)
Recommended Name: CCA tRNA nucleotidyltransferase 1, mitochondrial precursor  
Size: 434 amino acids; 50128 Da
Cofactor: Magnesium (Probable)
Subunit: Monomer, and homodimer; disulfide-linked
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAD34042.1; Type=Frameshift; Positions=16; Sequence=AAH12537.1; Type=Erroneous
initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for TRNT1:
1OU5 (3D)    
Secondary accessions: A8K2Z6 B7WP13 C9JKA2 Q8ND57 Q9BS97 Q9Y362
Alternative splicing: 3 isoforms:  Q96Q11-1   Q96Q11-2   Q96Q11-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRNT1: NX_Q96Q11

Explore proteomics data for TRNT1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96Q11

  • TRNT1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRNT1 Protein Expression
    REFSEQ proteins: NP_886552.2  
    ENSEMBL proteins: 
     ENSP00000251607   ENSP00000342985   ENSP00000280591   ENSP00000415100   ENSP00000400394  
     ENSP00000385745   ENSP00000388615   ENSP00000380881  

    Human Recombinant Protein Products for TRNT1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TRNT1
    OriGene Protein Over-expression Lysate for TRNT1
    OriGene MassSpec for TRNT1 
    OriGene Custom Protein Services for TRNT1
    GenScript Custom Purified and Recombinant Proteins Services for TRNT1
    Novus Biologicals TRNT1 Protein
    Novus Biologicals TRNT1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRNT1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005739mitochondrion IDA--
    GO:0005813centrosome IDA--

    TRNT1 for ontologies           About GeneDecksing



    TRNT1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TRNT1
    GenScript Custom Superior Antibodies Services for TRNT1
    Novus Biologicals TRNT1 Antibodies
    Abcam antibodies for TRNT1
    Cloud-Clone Corp. Antibodies for TRNT1 
    Search ThermoFisher Antibodies for TRNT1
    LSBio Antibodies in human, mouse, rat for TRNT1 

    Assay Products for TRNT1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TRNT1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRNT1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TRNT1 
    Cloud-Clone Corp. CLIAs for TRNT1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR002646 PolA_pol_head_dom
     IPR026973 Trnt1

    Graphical View of Domain Structure for InterPro Entry Q96Q11

    ProtoNet protein and cluster: Q96Q11

    1 Blocks protein domain: IPB002646 Polynucleotide adenylyltransferase

    UniProtKB/Swiss-Prot: TRNT1_HUMAN, Q96Q11
    Similarity: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family


    TRNT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRNT1_HUMAN, Q96Q11
    Function: Isoform 1: Adds and repairs the conserved 3'-CCA sequence necessary for the attachment of amino acids to
    the 3' terminus of tRNA molecules, using CTP and ATP as substrates
    Function: Isoform 2: Adds 2 C residues (CC-) to the 3' terminus of tRNA molecules instead of a complete CCA end as
    isoform 1 does (in vitro)
    Catalytic activity: A tRNA precursor + 2 CTP + ATP = a tRNA with a 3' CCA end + 3 diphosphate

         Enzyme Number (IUBMB): EC 2.7.7.721

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000049tRNA binding IDA11504732
    GO:0003723RNA binding ----
    GO:0004810tRNA adenylyltransferase activity IDA11504732
    GO:0005524ATP binding TAS11504732
    GO:0009022tRNA nucleotidyltransferase activity IEA--
         
    TRNT1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for TRNT1:
     G0/1 arrest  Increased G1 DNA content  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRNT1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRNT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRNT1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRNT1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRNT1
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate TRNT1:
    hsa-miR-3673 hsa-miR-200c* hsa-miR-491-3p hsa-miR-4276 hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmidTRNT1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TRNT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRNT1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRNT1
    Sirion Biotech Customized adenovirus for overexpression of TRNT1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TRNT1 (see all 10)
    OriGene ORF clones in mouse, rat for TRNT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRNT1 (NM_182916)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRNT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRNT1
    Sirion Biotech Customized lentivirus for stable overexpression of TRNT1 
                         Customized lentivirus expression plasmids for stable overexpression of TRNT1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TRNT1
    Search LifeMap BioReagents cell lines for TRNT1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRNT1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TRNT1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1RNA transport
    RNA transport

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for TRNT1):
        RNA transport


    TRNT1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRNT1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TRNT1 (ENSP000002516074) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PNPT1ENSP000003939534STRING: ENSP00000393953
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001680tRNA 3'-terminal CCA addition IEA--
    GO:0006396RNA processing ----
    GO:0006626protein targeting to mitochondrion TAS11504732
    GO:0042780tRNA 3'-end processing IDA11504732

    TRNT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRNT1

    4 HMDB Compounds for TRNT1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    Search CenterWatch for drugs/clinical trials and news about TRNT1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRNT1 gene (2 alternative transcripts): 
    NM_016000.3  NM_182916.2  

    Unigene Cluster for TRNT1:

    TRNA nucleotidyl transferase, CCA-adding, 1
    Hs.732725  [show with all ESTs]
    Unigene Representative Sequence: NM_182916
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000251607(uc003bpp.4 uc010hbv.3) ENST00000339437(uc003bpk.2)
    ENST00000280591 ENST00000465998 ENST00000434583(uc003bpm.2) ENST00000420393
    ENST00000402675(uc003bpn.1) ENST00000413000 ENST00000469632 ENST00000397779
    ENST00000482311
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRNT1
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate TRNT1:
    hsa-miR-3673 hsa-miR-200c* hsa-miR-491-3p hsa-miR-4276 hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmidTRNT1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TRNT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRNT1
    Clone
    Products:
         
    OriGene clones in human, mouse for TRNT1 (see all 10)
    OriGene ORF clones in mouse, rat for TRNT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRNT1 (NM_182916)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRNT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRNT1
    Sirion Biotech Customized lentivirus for stable overexpression of TRNT1 
                         Customized lentivirus expression plasmids for stable overexpression of TRNT1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TRNT1
    OriGene qSTAR qPCR primer pairs in human, mouse for TRNT1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRNT1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRNT1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRNT1

    Additional mRNA sequence: 

    AB063105.1 AF151805.1 AK124137.1 AK290411.1 AL834397.1 BC005184.1 

    13 DOTS entries:

    DT.95359149  DT.318120  DT.91752483  DT.99975413  DT.75101607  DT.100675181  DT.100823727  DT.100823724 
    DT.100768338  DT.91747870  DT.40268485  DT.95359138  DT.99969898 

    24/132 AceView cDNA sequences (see all 132):

    CR622655 AW584026 BI062461 AU102581 AA312954 N44129 BQ722111 BU187981 
    AI095700 BU165624 AI095914 CN480956 CA950036 BE552215 AL530384 NM_182916 
    BM919416 BM975635 AI926508 AV703724 BQ879199 BF223413 CA865559 CA865815 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TRNT1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11
    SP1:                          -     -           -     -     -                                                         
    SP2:                                                                                                                  
    SP3:                                            -     -     -                                                         
    SP4:                                                                                                                  
    SP5:                          -     -                                                                                 


    ECgene alternative splicing isoforms for TRNT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRNT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATTAACTT
    TRNT1 Expression
    About this image


    See TRNT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRNT1

    SOURCE GeneReport for Unigene cluster: Hs.732725
        SABiosciences Custom PCR Arrays for TRNT1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TRNT1
    OriGene qSTAR qPCR primer pairs in human, mouse for TRNT1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRNT1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRNT1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRNT1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRNT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TRNT1 gene from 8/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trnt11 , 5 tRNA nucleotidyl transferase, CCA-adding, 11, 5 87.94(n)1
    92.86(a)1
      6 (49.24 cM)5
    700471  NM_001242358.11  NP_001229287.11 
     1067691205 
    chicken
    (Gallus gallus)
    Aves TRNT11 tRNA nucleotidyl transferase, CCA-adding, 1 75.04(n)
    75.13(a)
      416103  XM_003642020.1  XP_003642068.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRNT16
    Uncharacterized protein
    74(a)
    1 ↔ 1
    2(174443340-174458573)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3984212 ATP(CTP)tRNA nucleotidyltransferase precursor 72.47(n)    AF466151.3 
    zebrafish
    (Danio rerio)
    Actinopterygii trnt11 tRNA nucleotidyl transferase, CCA-adding, 1 65.1(n)
    70.86(a)
      415249  NM_001002159.1  NP_001002159.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG21001 , 3 polynucleotide adenylyltransferase3
    CG21001
    49(a)3
    51.98(n)1
    50.89(a)1
      83C13
    407071  NM_141321.31  NP_649578.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F55B12.43
    hpo-311
    poly(A) polymerase like3
    Protein HPO-311
    43(a)3
    53.16(n)1
    46.58(a)1
      V(13825758-13827755)3
    35657861  NM_001028805.41  NP_001023976.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CCA1(YER168C)4 ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; more   --   5(522669-521029) 856915  NP_011095.1 


    ENSEMBL Gene Tree for TRNT1 (if available)
    TreeFam Gene Tree for TRNT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRNT1 gene

    TRNT1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TRNT1
    PGOHUM00000245052 PGOHUM00000246351


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/746 SNPs in TRNT1 are shown (see all 746)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0486984
    ----see VAR_0486982 P L mis40--------
    rs1513214391,2
    --3166705(+) CGGGCA/GTGGAG 1 -- us2k10--------
    rs40547591,2
    C,F,A,H--3166812(-) GGCTGG/CAGTGC 1 -- us2k16Minor allele frequency- C:0.00NS EA NA 416
    rs611207001,2
    C--3166844(+) ATCTC-/AAAAAA 1 -- us2k10--------
    rs17057801,2
    C,A--3166854(-) tttttC/Tttttt 1 -- us2k1 tfbs3 trp30--------
    rs1469297901,2
    --3167010(+) GTAAAG/TAACTT 1 -- us2k10--------
    rs592862161,2
    C,F--3167084(+) TACACC/ATGCAT 1 -- us2k14Minor allele frequency- A:0.34WA NA 242
    rs585220181,2
    C,F--3167085(+) ACACCC/TGCATA 1 -- us2k12Minor allele frequency- T:0.50WA NA 4
    rs1120993491,2
    C--3167134(+) GTGCCA/CAGCAC 1 -- us2k10--------
    rs731265371,2
    C,F--3167299(+) AAGGAT/CGATTT 1 -- us2k13Minor allele frequency- C:0.15WA 122

    HapMap Linkage Disequilibrium report for TRNT1 (3168600 - 3192563 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TRNT1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422274CNV Duplication17116639
    nsv521796CNV Loss19592680
    dgv787n67CNV Loss20364138
    nsv876405CNV Gain21882294
    nsv834604CNV Gain17160897
    esv2751994CNV Gain17911159

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TRNT1
    DNA2.0 Custom Variant and Variant Library Synthesis for TRNT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612907    OMIM disorders: --

    2 diseases for TRNT1:    About MalaCards
    pneumonia    tuberculosis


    TRNT1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TRNT1
    Human Genome Epidemiology (HuGE) Navigator: TRNT1 (3 documents)

    Export disorders for TRNT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRNT1 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with TRNT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of mammalian mitochondrial tRNA nucleotidyltransferases. (PubMed id 11504732)1, 2, 3, 9 Nagaike T.... Ueda T. (2001)
    2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. A splice variant of the human CCA-adding enzyme with modified activity. (PubMed id 17204286)1, 2 Lizano E....Morl M. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Crystal structure of the human CCA-adding enzyme: insights into template-independent polymerization. (PubMed id 12729736)1, 2 Augustin M.A....Steegborn C. (2003)
    7. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1, 2 Simpson J.C.... Wiemann S. (2000)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    10. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51095 HGNC: 17341 AceView: TRNT1 Ensembl:ENSG00000072756 euGenes: HUgn51095
    ECgene: TRNT1 Kegg: 51095 H-InvDB: TRNT1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRNT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRNT1 gene:
    Search GeneIP for patents involving TRNT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TRNT1  
     OriGene qPCR primer pairs and template standards for TRNT1   OriGene Protein Over-expression Lysate for TRNT1  
     OriGene MassSpec something-or-other for TRNT1   OriGene clones in human, mouse for TRNT1  
     OriGene qSTAR qPCR primer pairs in human, mouse for TRNT1   OriGene Purified Protein for TRNT1  
     OriGene ORF clones in mouse, rat for TRNT1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TRNT1   OriGene Custom Protein Services for TRNT1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRNT1
     QIAGEN SeqTarget long-range PCR primers for resequencing TRNT1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRNT1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRNT1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRNT1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRNT1
     GenScript Custom Purified and Recombinant Proteins Services for TRNT1 GenScript cDNA clones with any tag delivered in your preferred vector for TRNT1
     GenScript Custom Assay Services for TRNT1 GenScript Custom Superior Antibodies Services for TRNT1
     GenScript Custom overexpressing Cell Line Services for TRNT1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TRNT1 promoter
     Search Chromatin IP Primers for TRNT1
     RT2 qPCR Primer Assay in human, mouse, rat TRNT1
     Search GNC Networks for TRNT1
     SABiosciences Custom PCR Arrays for TRNT1
     Search Tocris compounds for TRNT1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TRNT1 antibodies
     TRNT1 proteins
     TRNT1 lysates
     Antibodies for TRNT1
     See all of Abcam's Antibodies, Kits and Proteins for TRNT1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for TRNT1
     Antibodies for TRNT1
     ELISAs for TRNT1
     CLIAs for TRNT1
     Search LifeMap BioReagents cell lines for TRNT1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRNT1
     SwitchGear 3'UTR luciferase reporter plasmids for TRNT1
     SwitchGear Promoter luciferase reporter plasmids for TRNT1
     Search ThermoFisher Antibodies for TRNT1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRNT1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TRNT1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRNT1
    Customized:
     lentivirus for stable overexpression of TRNT1
     lentivirus expression plasmids for stable overexpression of TRNT1
     adenovirus for overexpression of TRNT1
     LSBio Antibodies in human, mouse, rat for TRNT1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TRNT1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4