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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TRNT1 Gene

protein-coding GIFtS: 54
GCID: GC03P003168

tRNA nucleotidyl transferase, CCA-adding, 1

Explore 3 diseases affiliated with
TRNT1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
TRNA Nucleotidyl Transferase, CCA-Adding, 1¹ ²		Mt TRNA CCA-Pyrophosphorylase² ³
CCA1¹ ²		CGI-47¹
MtCCA¹ ²		CCA TRNA Nucleotidyltransferase 1, Mitochondrial²
Mitochondrial TRNA Nucleotidyl Transferase, CCA-Adding² ³		Mitochondrial CCA-Adding TRNA-Nucleotidyltransferase²
Mt CCA-Adding Enzyme² ³		TRNA-Nucleotidyltransferase 1, Mitochondrial²
Mt TRNA Adenylyltransferase² ³		EC 2.7.7.72³
Mt TRNA CCA-Diphosphorylase² ³

External Ids:	HGNC: 17341¹	Entrez Gene: 51095²	Ensembl: ENSG00000072756⁷	OMIM: 612907⁵	UniProtKB: Q96Q11³

Export aliases for TRNT1 gene to outside databases

Previous GC identifers: GC03P003097 GC03P003143 GC03P003102

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRNT1:

The CCA-adding enzyme TRNT1 (EC 2.7.7.25) is an essential enzyme that catalyzes the addition of the CCA terminus to the

3-prime end of tRNA precursors. This reaction is a fundamental prerequisite for mature tRNAs to become aminoacylated

and to participate in protein biosynthesis (Lizano et al., 2007 (PubMed 17204286)).(supplied by OMIM, Aug 2009)

UniProtKB/Swiss-Prot: TRNT1_HUMAN, Q96Q11

Function: Isoform 1: Adds and repairs the conserved 3'-CCA sequence necessary for the attachment of amino acids to the

3' terminus of tRNA molecules, using CTP and ATP as substrates

Function: Isoform 2: Adds 2 C residues (CC-) to the 3' terminus of tRNA molecules instead of a complete CCA end as

isoform 1 does (in vitro)

Gene Wiki entry for TRNT1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TRNT1 gene promoter:
HFH-3 ISGF-3 Sox5 CUTL1 RelA FOXL1 AREB6 FOXI1 FOXO4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRNT1 promoter sequence

Search SABiosciences Chromatin IP Primers for TRNT1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRNT1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.1 Ensembl cytogenetic band: 3p26.2 HGNC cytogenetic band: 3p25.1

TRNT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRNT1 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P003168: view genomic region (about GC identifiers)

Start:	3,168,600 bp from pter	End:	3,192,563 bp from pter
Size:	23,964 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TRNT1_HUMAN, Q96Q11 (See protein sequence)

Recommended Name: CCA tRNA nucleotidyltransferase 1, mitochondrial precursor

Size: 434 amino acids; 50128 Da

Cofactor: Magnesium (Probable)

Subunit: Monomer, and homodimer; disulfide-linked

Subcellular location: Mitochondrion

Sequence caution: Sequence=AAD34042.1; Type=Frameshift; Positions=16; Sequence=AAH12537.1; Type=Erroneous initiation;

Note=Translation N-terminally extended;

1 PDB 3D structure from and Proteopedia for TRNT1:

1OU5 (3D)

Secondary accessions: A8K2Z6 B7WP13 C9JKA2 Q8ND57 Q9BS97 Q9Y362

Alternative splicing: 3 isoforms: Q96Q11-1 Q96Q11-2 Q96Q11-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRNT1: NX_Q96Q11

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96Q11

TRNT1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_886552.2

ENSEMBL proteins:

ENSP00000251607 ENSP00000342985 ENSP00000280591 ENSP00000415100 ENSP00000400394

ENSP00000385745 ENSP00000388615 ENSP00000380881

Human Recombinant Protein Products for TRNT1:

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	Novus Biologicals TRNT1 Protein Novus Biologicals TRNT1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TRNT1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IDA	--
GO:0005739	mitochondrion	IDA	--
GO:0005813	centrosome	IDA	--

TRNT1 for ontologies About GeneDecksing

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Assay Products for TRNT1:

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	Uscn ELISAs and CLIAs for TRNT1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TRNT1 for domains About GeneDecksing

2 InterPro domains/families:

IPR002646 PolA_pol_head_dom

IPR026973 Trnt1

Graphical View of Domain Structure for InterPro Entry Q96Q11

ProtoNet protein and cluster: Q96Q11

1 Blocks protein family: IPB002646 Polynucleotide adenylyltransferase

UniProtKB/Swiss-Prot: TRNT1_HUMAN, Q96Q11

Similarity: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TRNT1_HUMAN, Q96Q11

Function: Isoform 1: Adds and repairs the conserved 3'-CCA sequence necessary for the attachment of amino acids to the

3' terminus of tRNA molecules, using CTP and ATP as substrates

Function: Isoform 2: Adds 2 C residues (CC-) to the 3' terminus of tRNA molecules instead of a complete CCA end as

isoform 1 does (in vitro)

Catalytic activity: A tRNA precursor + 2 CTP + ATP = a tRNA with a 3' CCA end + 3 diphosphate

Enzyme Number (IUBMB): EC 2.7.7.72¹

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000049	tRNA binding	IDA	11504732
GO:0004810	tRNA adenylyltransferase activity	IDA	11504732
GO:0005524	ATP binding	TAS	11504732
GO:0009022	tRNA nucleotidyltransferase activity	IEA	--
GO:0052927	CTP:tRNA cytidylyltransferase activity	IEA	--

TRNT1 for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for TRNT1:

G0/1 arrest

Increased G1 DNA content

Synthetic lethal with Ras

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TRNT1

miRNA Products:		OriGene 3'-UTR Clone: TRNT1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRNT1
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate TRNT1:
		hsa-miR-3673 hsa-miR-200c* hsa-miR-491-3p hsa-miR-4276 hsa-miR-550a*
		SwitchGear 3'UTR luciferase reporter plasmid: TRNT1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against TRNT1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for TRNT1
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRNT1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRNT1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRNT1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

RNA transport

RNA transport

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Kegg Pathway (Kegg details for TRNT1):

RNA transport

TRNT1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TRNT1

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for TRNT1 (ENSP00000251607⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PNPT1	ENSP00000393953⁴	STRING: ENSP00000393953

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001680	tRNA 3'-terminal CCA addition	IEA	--
GO:0006626	protein targeting to mitochondrion	TAS	11504732
GO:0042780	tRNA 3'-end processing	IDA	11504732

TRNT1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TRNT1

4 HMDB Compounds for TRNT1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Magnesium	Magnesium (see all 2)	7439-95-4	--
Phosphoric acid	acide phosphorique (FRENCH) (see all 20)	7664-38-2	--
Pyrophosphate	(4-)Diphosphoric acid ion (see all 10)	14000-31-8	--

Search CenterWatch for drugs/clinical trials and news about TRNT1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TRNT1 gene (2 alternative transcripts):

NM_016000.3 NM_182916.2

Unigene Cluster for TRNT1:

TRNA nucleotidyl transferase, CCA-adding, 1

Hs.732725 [show with all ESTs]

Unigene Representative Sequence: NM_182916

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000251607(uc003bpp.4 uc010hbv.3) ENST00000339437(uc003bpk.2)

ENST00000280591 ENST00000465998 ENST00000434583(uc003bpm.2) ENST00000420393

ENST00000402675(uc003bpn.1) ENST00000413000 ENST00000469632 ENST00000397779

ENST00000482311

miRNA Products:		OriGene 3'-UTR Clone: TRNT1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRNT1
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate TRNT1:
		hsa-miR-3673 hsa-miR-200c* hsa-miR-491-3p hsa-miR-4276 hsa-miR-550a*
		SwitchGear 3'UTR luciferase reporter plasmid: TRNT1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRNT1 (see all 7) OriGene shRNA RFP: TRNT1 OriGene siRNA: TRNT1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRNT1
		Sirion Biotech Custom design and validation of potent shRNA sequences against TRNT1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRNT1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRNT1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TRNT1 (NM_182916)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRNT1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRNT1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRNT1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRNT1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRNT1

Additional cDNA sequence:

AB063105.1 AF151805.1 AK124137.1 AK290411.1 AL834397.1 BC005184.1

13 DOTS entries:

DT.95359149 DT.318120 DT.91752483 DT.99975413 DT.75101607 DT.100675181 DT.100823727 DT.100823724

DT.100768338 DT.91747870 DT.40268485 DT.95359138 DT.99969898

24/132 AceView cDNA sequences (see all 132):

AA312954 BQ722111 CR622655 BU165624 AW584026 AI095700 BU187981 AI095914

BI062461 AU102581 N44129 BQ772254 BU677666 AV703724 AW965992 BG772731

CB956630 CB119929 BF059440 CN480956 AI863438 BQ435447 AI400233 AA258000

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TRNT1 (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	^	10	^	11
SP1:									-		-				-		-		-
SP2:
SP3:															-		-		-
SP4:
SP5:									-		-

ECgene alternative splicing isoforms for TRNT1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRNT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGATTAACTT

About this image
See TRNT1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRNT1

SOURCE GeneReport for Unigene cluster: Hs.732725
SABiosciences Custom PCR Arrays for TRNT1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRNT1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRNT1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRNT1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for TRNT1 gene from 10/35 species (see all 35) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Trnt1^{1 , 5}	tRNA nucleotidyl transferase, CCA-adding, 1^{1, 5}	87.94(n)¹ 92.86(a)¹		6 (49.24 cM)⁵ 70047¹ NM_001242358.1¹ NP_001229287.1¹ 106769120⁵
chicken (Gallus gallus)	Aves	TRNT1¹	tRNA nucleotidyl transferase, CCA-adding, 1	75.04(n) 75.13(a)		416103 XM_003642020.1 XP_003642068.1
lizard (Anolis carolinensis)	Reptilia	TRNT1⁶	--	74(a)	1 ↔ 1	2(174445493-174458573)
African clawed frog (Xenopus laevis)	Amphibia	LOC398421²	ATP(CTP)tRNA nucleotidyltransferase precursor	72.47(n)		AF466151.3
zebrafish (Danio rerio)	Actinopterygii	trnt1¹	tRNA nucleotidyl transferase, CCA-adding, 1	65.1(n) 70.86(a)		415249 NM_001002159.1 NP_001002159.1
fruit fly (Drosophila melanogaster)	Insecta	CG2100^{1 , 3}	polynucleotide adenylyltransferase³ CG2100¹	49(a)³ 51.98(n)¹ 50.89(a)¹		83C1³ 40707¹ NM_141321.3¹ NP_649578.1¹
worm (Caenorhabditis elegans)	Secernentea	F55B12.4³ hpo-31¹	poly(A) polymerase like³ Protein HPO-31¹	43(a)³ 53.16(n)¹ 46.58(a)¹		V(13825758-13827755)³ 3565786¹ NM_001028805.4¹ NP_001023976.1¹
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G17580⁶ AT3G48830⁶ (see all 5)	polynucleotide adenylyltransferase-like protein polynucleotide adenylyltransferase domain and RNA ... (see all 5)	9(a) 7(a) (see all 5)	many → 1 many → 1 (see all 5)	2(7646463-7650320) 3(18103152-18110216)
rice (Oryza sativa)	Liliopsida	-- -- (see all 3)	tRNA nucleotidyltransferase/polyA polymerase famil... tRNA nucleotidyltransferase/polyA polymerase famil... (see all 3)	18(a) 13(a) (see all 3)	many → 1 many → 1 (see all 3)	4(19326301-19332840) 3(1797692-1803322)
E. coli (Escherichia coli)	Gamma proteobacteria	pcnB⁶ cca⁶	poly(A) polymerase I fused tRNA nucleotidyl transferase/2'3'-cyclic pho...	15(a) 15(a)	possible ortholog possible ortholog	Chromosome(157729-159126) Chromosome(3199913-3201151)

ENSEMBL Gene Tree for TRNT1 (if available)
TreeFam Gene Tree for TRNT1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TRNT1 gene

TRNT1 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for TRNT1
PGOHUM00000245052 PGOHUM00000246351

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs151321439^1,2		--	3166705(+)	`CGGGCA/GTGGAG`	1	--	us2k¹		0	--	--	--	--
rs4054759^1,2	C,A,H	--	3166812(-)	`GGCTGG/CAGTGC`	1	--	us2k¹		6		NS EA NA	416
rs61120700^1,2	C	--	3166844(+)	`ATCTC-/AAAAAA`	1	--	us2k¹		0	--	--	--	--
rs58003526^1,2	C	--	3166853(+)	`AAAAAGAAA/- AAAAA`	1	--	us2k¹		1		NA	2
rs1705780^1,2	C,A	--	3166854(-)	`tttttC/Tttttt`	1	--	us2k¹ tfbs³ trp³		0	--	--	--	--
rs146929790^1,2		--	3167010(+)	`GTAAAG/TAACTT`	1	--	us2k¹		0	--	--	--	--
rs59286216^1,2	C,F	--	3167084(+)	`TACACC/ATGCAT`	1	--	us2k¹		4		WA NA	242
rs58522018^1,2	C,F	--	3167085(+)	`ACACCC/TGCATA`	1	--	us2k¹		2		WA NA	4
rs112099349^1,2	C	--	3167134(+)	`GTGCCA/CAGCAC`	1	--	us2k¹		0	--	--	--	--
rs73126537^1,2	C,F	--	3167299(+)	`AAGGAT/CGATTT`	1	--	us2k¹		3		WA	122

HapMap Linkage Disequilibrium report for TRNT1 (3168600 - 3192563 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TRNT1
2 CNVs: 8407 5211

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TRNT1 for disorders           About GeneDecksing

OMIM gene information: 612907    OMIM disorders: --

3 diseases for TRNT1:    About MalaCards

pneumonia tuberculosis mycobacterium tuberculosis

Human Genome Epidemiology (HuGE) Navigator: TRNT1 (3 documents)

Export disorders for TRNT1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TRNT1 gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with TRNT1)

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world of online information

Identification and characterization of mammalian mitochondrial tRNA nucleotidyltransferases. (PubMed id 11504732)^{1, 2, 3, 9} Nagaike T.... Ueda T. (2001)
Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)^{1, 2, 3} Lai C.H....Lin W. (2000)
A splice variant of the human CCA-adding enzyme with modified activity. (PubMed id 17204286)^{1, 2} Lizano E....Morl M. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Crystal structure of the human CCA-adding enzyme: insights into template-independent polymerization. (PubMed id 12729736)^{1, 2} Augustin M.A....Steegborn C. (2003)
Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)^{1, 2} Simpson J.C.... Wiemann S. (2000)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 51095	HGNC: 17341	AceView: TRNT1	Ensembl:ENSG00000072756	euGenes: HUgn51095
ECgene: TRNT1	Kegg: 51095	H-InvDB: TRNT1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TRNT1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TRNT1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TRNT1 gene:
Search GeneIP for patents involving TRNT1

GeneCards and IP:
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tRNA nucleotidyl transferase, CCA-adding, 1

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tRNA nucleotidyl transferase, CCA-adding, 1

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