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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TRNP1 Gene

protein-coding GIFtS: 36
GCID: GC01P027320

TMF1-regulated nuclear protein 1

(Previous name: chromosome 1 open reading frame 225 )
(Previous symbol: C1orf225)

Search for TRNP1
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
TMF1-Regulated Nuclear Protein 1¹ ²		TNRP²
C1orf225¹ ² ³		TMF Regulated Nuclear Protein²
LOC388610¹		TMF-Regulated Nuclear Protein 1²
Chromosome 1 Open Reading Frame 225¹		TRNP³

External Ids:	HGNC: 34348¹	Entrez Gene: 388610²	Ensembl: ENSG00000253368⁷	UniProtKB: Q6NT89³

Export aliases for TRNP1 gene to outside databases

Previous GC identifers: GC01P027195 GC01P025575

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TRNP1_HUMAN, Q6NT89

Function: When overexpressed, accelerates the proliferation rate of cells by enhancing their progression through key

cell-cycle transition points (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004610.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TRNP1 gene promoter:
RP58 HOXA3 Bach2 Olf-1 Lmo2 HNF-4alpha1 GATA-1 CREB HEN1 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRNP1 promoter sequence

Search SABiosciences Chromatin IP Primers for TRNP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRNP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11 Ensembl cytogenetic band: 1p36.11 HGNC cytogenetic band: 1p36.11

TRNP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRNP1 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P027320: view genomic region (about GC identifiers)

Start:	27,320,195 bp from pter	End:	27,327,389 bp from pter
Size:	7,195 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TRNP1_HUMAN, Q6NT89 (See protein sequence)

Recommended Name: TMF-regulated nuclear protein 1

Size: 227 amino acids; 23482 Da

Subunit: Interacts with TMF1 (By similarity)

Subcellular location: Nucleus (By similarity)

Explore the universe of human proteins at neXtProt for TRNP1: NX_Q6NT89

Post-translational modifications:

Ubiquitinated, leading to its degradation by the proteasome (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6NT89

TRNP1 Protein expression data from MOPED and PaxDb: --

REFSEQ proteins: NP_001013664.1

ENSEMBL proteins:

ENSP00000429216 ENSP00000436467

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

TRNP1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q6NT89

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TRNP1_HUMAN, Q6NT89

Function: When overexpressed, accelerates the proliferation rate of cells by enhancing their progression through key

cell-cycle transition points (By similarity)

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TRNP1

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007049	cell cycle	IEA	--

TRNP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TRNP1 gene:

NM_001013642.2

Unigene Cluster for TRNP1:

TMF1-regulated nuclear protein 1

Hs.355747 [show with all ESTs]

Unigene Representative Sequence: NM_001013642

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000522111(uc001bnj.4) ENST00000531285

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Additional cDNA sequence: BC069216.1

3 DOTS entries:

DT.92420466 DT.95363667 DT.92420465

24/72 AceView cDNA sequences (see all 72):

AA532548 BM820130 AI377954 BG036482 CK904126 AW151636 BM310453 AA379296

AI093549 BQ189050 AI066629 BM310758 AW663347 AW051390 BE671797 AI366714

BM718216 BE219163 AI631660 BF907724 AI745252 AI768656 CB119700 AI370989

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRNP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGTTCTGAG

About this image

TRNP1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Mature Rod Bipolar Cells

Bipolar, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Genevestigator expression for TRNP1

SOURCE GeneReport for Unigene cluster: Hs.355747

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for TRNP1 gene from 1/5 species (see all 5) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Trnp1^{1 , 5}	TMF1-regulated nuclear protein 1^{1, 5}	85.74(n)¹ 89.19(a)¹		4 (66.25 cM)⁵ 69539¹ NM_001081156.2¹ NP_001074625.1¹ 133491100⁵

ENSEMBL Gene Tree for TRNP1 (if available)
TreeFam Gene Tree for TRNP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs182006457^1,2	--	27318251(+)	`ATGGGA/GGGAGG`	1	--	us2k¹		0	--	--	--	--
rs113188479^1,2	--	27318512(+)	`AGTGTT/GTGGTA`	1	--	us2k¹		2		CSA WA	119
rs148297728^1,2	--	27318609(+)	`TCCCAC/GATAAA`	1	--	us2k¹		0	--	--	--	--
rs186219596^1,2	--	27318621(+)	`AACGTA/CCCTCC`	1	--	us2k¹		0	--	--	--	--
rs113756306^1,2	--	27318929(+)	`GCTGGA/GACTAC`	1	--	us2k¹		2		CSA WA	119
rs141489187^1,2	--	27319430(+)	`GCCACC/TGCGCC`	1	--	us2k¹		0	--	--	--	--
rs78345898^1,2	--	27319570(+)	`GGCTCA/GGCGGC`	1	--	us2k¹		1		NA	120
rs189805490^1,2	--	27319695(+)	`CCCTAC/GTGAGG`	1	--	us2k¹		0	--	--	--	--
rs145668835^1,2	--	27319791(+)	`GAGCAC/TGGCAC`	1	--	us2k¹		0	--	--	--	--
rs181422723^1,2	--	27319822(+)	`TTCTAC/GCCCAG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TRNP1 (27320195 - 27327389 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TRNP1
1 CNV: 4218

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TRNP1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TRNP1)

Utopia: connect your pdf to the dynamic
world of online information

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
trnp: A conserved mammalian gene encoding a nuclear protein that accelerates cell-cycle progression. (PubMed id 16792503)¹ Volpe M....Nir U. (2006)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 388610	HGNC: 34348	AceView: LOC388610	Ensembl:ENSG00000253368	euGenes: HUgn388610
ECgene: TRNP1	H-InvDB: TRNP1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TRNP1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TRNP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TRNP1 gene:
Search GeneIP for patents involving TRNP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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TRNP1 Gene

TMF1-regulated nuclear protein 1

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TRNP1 Gene

TMF1-regulated nuclear protein 1

Aliasesfor TRNP1 gene

Summariesfor TRNP1 gene

Genomic Viewsfor TRNP1 gene

Proteinsfor TRNP1 gene

Protein Domains /Familiesfor TRNP1 gene

Functionfor TRNP1 gene

Pathways & Interactionsfor TRNP1 gene

Drugs & Compoundsfor TRNP1 gene

Transcriptsfor TRNP1 gene

Expression for TRNP1 gene

Orthologsfor TRNP1 gene

Paralogsfor TRNP1 gene

Genomic Variantsfor TRNP1 gene

Disorders / Diseasesfor TRNP1 gene

Publicationsfor TRNP1 gene

External Searches for TRNP1 gene

Genome Databases showing TRNP1 gene

Other Databases showing TRNP1 gene

Specialized Databases showing TRNP1 gene

Intellectual Propertyfor TRNP1 gene

Productsfor TRNP1 gene

View Random Gene

Aliases
for TRNP1 gene

Summaries
for TRNP1 gene

Genomic Views
for TRNP1 gene

Proteins
for TRNP1 gene

Protein Domains /
Families
for TRNP1 gene

Function
for TRNP1 gene

Pathways & Interactions
for TRNP1 gene

Drugs & Compounds
for TRNP1 gene

Transcripts
for TRNP1 gene

Expression
for TRNP1 gene

Orthologs
for TRNP1 gene

Paralogs
for TRNP1 gene

Genomic Variants
for TRNP1 gene

Disorders / Diseases
for TRNP1 gene

Publications
for TRNP1 gene

Intellectual Property
for TRNP1 gene

Products
for TRNP1 gene