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Aliases for TRNP1 Gene

Aliases for TRNP1 Gene

  • TMF1-Regulated Nuclear Protein 1 2 3 5
  • C1orf225 3 4
  • Chromosome 1 Open Reading Frame 225 2
  • TMF-Regulated Nuclear Protein 1 3
  • TRNP 4
  • TNRP 3

External Ids for TRNP1 Gene

Previous HGNC Symbols for TRNP1 Gene

  • C1orf225

Previous GeneCards Identifiers for TRNP1 Gene

  • GC01P027195
  • GC01P027320
  • GC01P025575

Summaries for TRNP1 Gene

GeneCards Summary for TRNP1 Gene

TRNP1 (TMF1-Regulated Nuclear Protein 1) is a Protein Coding gene. Diseases associated with TRNP1 include Autoimmune Disease Of Gastrointestinal Tract.

UniProtKB/Swiss-Prot for TRNP1 Gene

  • DNA-binding factor that regulates the expression of a subset of genes and plays a key role in tangential, radial, and lateral expansion of the brain neocortex. Regulates neural stem cells proliferation and the production of intermediate neural progenitors and basal radial glial cells affecting the process of cerebral cortex gyrification. May control the proliferation rate of cells by regulating their progression through key cell-cycle transition points (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRNP1 Gene

Genomics for TRNP1 Gene

Regulatory Elements for TRNP1 Gene

Enhancers for TRNP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TRNP1 on UCSC Golden Path with GeneCards custom track

Promoters for TRNP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TRNP1 Gene

Chromosome:
1
Start:
26,993,667 bp from pter
End:
27,000,898 bp from pter
Size:
7,232 bases
Orientation:
Plus strand

Genomic View for TRNP1 Gene

Genes around TRNP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRNP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRNP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRNP1 Gene

Proteins for TRNP1 Gene

  • Protein details for TRNP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NT89-TRNP1_HUMAN
    Recommended name:
    TMF-regulated nuclear protein 1
    Protein Accession:
    Q6NT89

    Protein attributes for TRNP1 Gene

    Size:
    227 amino acids
    Molecular mass:
    23482 Da
    Quaternary structure:
    • Interacts with TMF1; may regulate TRNP1 proteasomal degradation.

neXtProt entry for TRNP1 Gene

Post-translational modifications for TRNP1 Gene

  • Ubiquitinated, leading to its degradation by the proteasome.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRNP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRNP1 Gene

Domains & Families for TRNP1 Gene

Protein Domains for TRNP1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TRNP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRNP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TRNP1 Gene

Function for TRNP1 Gene

Molecular function for TRNP1 Gene

UniProtKB/Swiss-Prot Function:
DNA-binding factor that regulates the expression of a subset of genes and plays a key role in tangential, radial, and lateral expansion of the brain neocortex. Regulates neural stem cells proliferation and the production of intermediate neural progenitors and basal radial glial cells affecting the process of cerebral cortex gyrification. May control the proliferation rate of cells by regulating their progression through key cell-cycle transition points (By similarity).

Gene Ontology (GO) - Molecular Function for TRNP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding ISS --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with TRNP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRNP1 Gene

Localization for TRNP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRNP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRNP1 Gene COMPARTMENTS Subcellular localization image for TRNP1 gene
Compartment Confidence
nucleus 4
chloroplast 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for TRNP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,ISS --
GO:0005719 colocalizes_with nuclear euchromatin IEA,ISS --
genes like me logo Genes that share ontologies with TRNP1: view

Pathways & Interactions for TRNP1 Gene

SuperPathways for TRNP1 Gene

No Data Available

Interacting Proteins for TRNP1 Gene

Selected Interacting proteins: Q6NT89-TRNP1_HUMAN for TRNP1 Gene via IID

Symbol External ID(s) Details
TMF1

Gene Ontology (GO) - Biological Process for TRNP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007049 cell cycle IEA --
GO:0021696 cerebellar cortex morphogenesis IEA,ISS --
GO:0042127 regulation of cell proliferation IEA,ISS --
genes like me logo Genes that share ontologies with TRNP1: view

No data available for Pathways by source and SIGNOR curated interactions for TRNP1 Gene

Drugs & Compounds for TRNP1 Gene

No Compound Related Data Available

Transcripts for TRNP1 Gene

mRNA/cDNA for TRNP1 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(72) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRNP1 Gene

TMF1-regulated nuclear protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRNP1 Gene

No ASD Table

Relevant External Links for TRNP1 Gene

GeneLoc Exon Structure for
TRNP1
ECgene alternative splicing isoforms for
TRNP1

Expression for TRNP1 Gene

mRNA expression in normal human tissues for TRNP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRNP1 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.2).

Protein differential expression in normal tissues from HIPED for TRNP1 Gene

This gene is overexpressed in Lung (24.4), Liver (17.8), Pancreas (11.8), and Heart (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRNP1 Gene



Protein tissue co-expression partners for TRNP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRNP1 Gene:

TRNP1

SOURCE GeneReport for Unigene cluster for TRNP1 Gene:

Hs.355747
genes like me logo Genes that share expression patterns with TRNP1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TRNP1 Gene

Orthologs for TRNP1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRNP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRNP1 34
  • 91.75 (n)
  • 92.78 (a)
mouse
(Mus musculus)
Mammalia Trnp1 34
  • 81.61 (n)
  • 83.41 (a)
Trnp1 16
Trnp1 35
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRNP1 34
  • 97.57 (n)
  • 95.83 (a)
rat
(Rattus norvegicus)
Mammalia Trnp1 34
  • 78.52 (n)
  • 78.87 (a)
oppossum
(Monodelphis domestica)
Mammalia TRNP1 35
  • 69 (a)
OneToOne
Species where no ortholog for TRNP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRNP1 Gene

ENSEMBL:
Gene Tree for TRNP1 (if available)
TreeFam:
Gene Tree for TRNP1 (if available)

Paralogs for TRNP1 Gene

No data available for Paralogs for TRNP1 Gene

Variants for TRNP1 Gene

Sequence variations from dbSNP and Humsavar for TRNP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs6689941 - 26,993,865(+) CGCCC(C/T)GGGAT reference, missense
rs1890052 -- 26,995,661(+) GTTTC(A/G)CTCTT intron-variant
rs2311230 -- 26,999,653(-) GATCC(A/C)CTAGC intron-variant
rs3028529 -- 26,997,319(-) TTTTT(-/T)CTTGA intron-variant
rs3028532 -- 26,996,791(-) CACAC(-/AC/ACAC)TAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRNP1 Gene

Variant ID Type Subtype PubMed ID
nsv1000012 CNV gain 25217958
nsv834524 CNV gain+loss 17160897

Variation tolerance for TRNP1 Gene

Gene Damage Index Score: 0.27; 6.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRNP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRNP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRNP1 Gene

Disorders for TRNP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRNP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
autoimmune disease of gastrointestinal tract
- elite association - COSMIC cancer census association via MalaCards
Search TRNP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TRNP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRNP1
genes like me logo Genes that share disorders with TRNP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRNP1 Gene

Publications for TRNP1 Gene

  1. Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate. (PMID: 23622239) Stahl R. … Goetz M. (Cell 2013) 3 4 65
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  3. trnp: A conserved mammalian gene encoding a nuclear protein that accelerates cell-cycle progression. (PMID: 16792503) Volpe M. … Nir U. (DNA Cell Biol. 2006) 3 65
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 65

Products for TRNP1 Gene

Sources for TRNP1 Gene

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