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Aliases for TRNAU1AP Gene

Aliases for TRNAU1AP Gene

  • TRNA Selenocysteine 1 Associated Protein 1 2 3 5
  • TRNA Selenocysteine Associated Protein 1 2 3
  • TRNA Selenocysteine-Associated Protein 1 3 4
  • TRSPAP1 3 4
  • SECP43 3 4
  • TRNA Selenocysteine Associated Protein (SECP43) 3
  • PRO1902 3

External Ids for TRNAU1AP Gene

Previous HGNC Symbols for TRNAU1AP Gene

  • TRSPAP1

Previous GeneCards Identifiers for TRNAU1AP Gene

  • GC01P028753
  • GC01P028879
  • GC01P027133

Summaries for TRNAU1AP Gene

GeneCards Summary for TRNAU1AP Gene

TRNAU1AP (TRNA Selenocysteine 1 Associated Protein 1) is a Protein Coding gene. Among its related pathways are Selenium Metabolism and Selenoproteins. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is C6orf52.

UniProtKB/Swiss-Prot for TRNAU1AP Gene

  • Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRNAU1AP Gene

Genomics for TRNAU1AP Gene

Regulatory Elements for TRNAU1AP Gene

Enhancers for TRNAU1AP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRNAU1AP on UCSC Golden Path with GeneCards custom track

Promoters for TRNAU1AP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRNAU1AP on UCSC Golden Path with GeneCards custom track

Genomic Location for TRNAU1AP Gene

Chromosome:
1
Start:
28,553,017 bp from pter
End:
28,578,545 bp from pter
Size:
25,529 bases
Orientation:
Plus strand

Genomic View for TRNAU1AP Gene

Genes around TRNAU1AP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRNAU1AP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRNAU1AP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRNAU1AP Gene

Proteins for TRNAU1AP Gene

  • Protein details for TRNAU1AP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX07-TSAP1_HUMAN
    Recommended name:
    tRNA selenocysteine 1-associated protein 1
    Protein Accession:
    Q9NX07
    Secondary Accessions:
    • Q86SU7

    Protein attributes for TRNAU1AP Gene

    Size:
    287 amino acids
    Molecular mass:
    32499 Da
    Quaternary structure:
    • Component of the tRNA(Sec) complex composed at least of EEFSEC, SECISBP2, SEPHS1, SEPSECS, TRNAU1AP and tRNA(Sec). Found in a complex with tRNA(Sec). Interacts with SEPSECS. Associates with mRNP and/or polysomes (By similarity). Found in a complex with EEFSEC, SECISBP2, TRNAU1AP and tRNA(Sec).

    Three dimensional structures from OCA and Proteopedia for TRNAU1AP Gene

    Alternative splice isoforms for TRNAU1AP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRNAU1AP Gene

Proteomics data for TRNAU1AP Gene at MOPED

Post-translational modifications for TRNAU1AP Gene

  • Ubiquitination at Lys 127, Lys 137, Lys 151, and Lys 166
  • Modification sites at PhosphoSitePlus

Other Protein References for TRNAU1AP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRNAU1AP Gene

Domains & Families for TRNAU1AP Gene

Gene Families for TRNAU1AP Gene

Protein Domains for TRNAU1AP Gene

Suggested Antigen Peptide Sequences for TRNAU1AP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NX07

UniProtKB/Swiss-Prot:

TSAP1_HUMAN :
  • Contains 2 RRM (RNA recognition motif) domains.
  • Belongs to the RRM TRSPAP family.
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the RRM TRSPAP family.
genes like me logo Genes that share domains with TRNAU1AP: view

Function for TRNAU1AP Gene

Molecular function for TRNAU1AP Gene

UniProtKB/Swiss-Prot Function:
Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis (By similarity).

Gene Ontology (GO) - Molecular Function for TRNAU1AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with TRNAU1AP: view

Phenotypes for TRNAU1AP Gene

GenomeRNAi human phenotypes for TRNAU1AP:
genes like me logo Genes that share phenotypes with TRNAU1AP: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRNAU1AP Gene

Localization for TRNAU1AP Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRNAU1AP Gene

Nucleus. Cytoplasm. Note=Abundant in the nucleus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRNAU1AP Gene COMPARTMENTS Subcellular localization image for TRNAU1AP gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for TRNAU1AP Gene

Pathways & Interactions for TRNAU1AP Gene

genes like me logo Genes that share pathways with TRNAU1AP: view

Pathways by source for TRNAU1AP Gene

1 BioSystems pathway for TRNAU1AP Gene

Interacting Proteins for TRNAU1AP Gene

Gene Ontology (GO) - Biological Process for TRNAU1AP Gene

None

No data available for SIGNOR curated interactions for TRNAU1AP Gene

Drugs & Compounds for TRNAU1AP Gene

No Compound Related Data Available

Transcripts for TRNAU1AP Gene

Unigene Clusters for TRNAU1AP Gene

TRNA selenocysteine 1 associated protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRNAU1AP Gene

No ASD Table

Relevant External Links for TRNAU1AP Gene

GeneLoc Exon Structure for
TRNAU1AP
ECgene alternative splicing isoforms for
TRNAU1AP

Expression for TRNAU1AP Gene

mRNA expression in normal human tissues for TRNAU1AP Gene

Protein differential expression in normal tissues from HIPED for TRNAU1AP Gene

This gene is overexpressed in Lymph node (25.5), Fetal ovary (11.3), Retina (9.2), and CD8 Tcells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRNAU1AP Gene



SOURCE GeneReport for Unigene cluster for TRNAU1AP Gene Hs.533626

genes like me logo Genes that share expression patterns with TRNAU1AP: view

Protein tissue co-expression partners for TRNAU1AP Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRNAU1AP Gene

Orthologs for TRNAU1AP Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRNAU1AP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRNAU1AP 35
  • 94.08 (n)
  • 99.65 (a)
TRNAU1AP 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRNAU1AP 35
  • 93.61 (n)
  • 99.65 (a)
TRNAU1AP 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trnau1ap 35
  • 92.57 (n)
  • 98.95 (a)
Trnau1ap 16
Trnau1ap 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRNAU1AP 35
  • 99.74 (n)
  • 100 (a)
TRNAU1AP 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trnau1ap 35
  • 93.38 (n)
  • 99.3 (a)
oppossum
(Monodelphis domestica)
Mammalia TRNAU1AP 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRNAU1AP 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRNAU1AP 35
  • 80.26 (n)
  • 93.38 (a)
TRNAU1AP 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 40 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11585 35
African clawed frog
(Xenopus laevis)
Amphibia secp43-prov 35
zebrafish
(Danio rerio)
Actinopterygii trnau1apb 35
  • 62.06 (n)
  • 56.03 (a)
wufa56b07 35
C19H6orf52 36
  • 47 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3491 35
fruit fly
(Drosophila melanogaster)
Insecta CG15440 35
  • 54.65 (n)
  • 52.33 (a)
CG15440 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T07F10.3 36
  • 15 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAM8 36
  • 12 (a)
ManyToMany
NGR1 36
  • 11 (a)
ManyToMany
NAM8 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 16 (a)
OneToMany
Species with no ortholog for TRNAU1AP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRNAU1AP Gene

ENSEMBL:
Gene Tree for TRNAU1AP (if available)
TreeFam:
Gene Tree for TRNAU1AP (if available)

Paralogs for TRNAU1AP Gene

Paralogs for TRNAU1AP Gene

genes like me logo Genes that share paralogs with TRNAU1AP: view

Variants for TRNAU1AP Gene

Sequence variations from dbSNP and Humsavar for TRNAU1AP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs4633256 -- 28,566,207(-) ctccc(A/G)agcag intron-variant
rs4654330 -- 28,575,626(+) cccag(A/C)taatt intron-variant
rs4654389 -- 28,561,855(+) atcac(A/G)aggtc intron-variant
rs6686029 -- 28,572,310(+) tgcct(C/T)agcct intron-variant
rs6662008 -- 28,572,762(+) acccc(A/G)tctct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRNAU1AP Gene

Variant ID Type Subtype PubMed ID
dgv34e199 CNV Deletion 23128226

Variation tolerance for TRNAU1AP Gene

Residual Variation Intolerance Score: 25.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRNAU1AP Gene

HapMap Linkage Disequilibrium report
TRNAU1AP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRNAU1AP Gene

Disorders for TRNAU1AP Gene

Relevant External Links for TRNAU1AP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRNAU1AP

No disorders were found for TRNAU1AP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRNAU1AP Gene

Publications for TRNAU1AP Gene

  1. Supramolecular complexes mediate selenocysteine incorporation in vivo. (PMID: 16508009) Small-Howard A. … Berry M.J. (Mol. Cell. Biol. 2006) 3 4 67
  2. Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery. (PMID: 16230358) Xu X.M. … Hatfield D.L. (J. Biol. Chem. 2005) 2 3
  3. Identification of a protein component of a mammalian tRNA(Sec) complex implicated in the decoding of UGA as selenocysteine. (PMID: 10606267) Ding F. … Grabowski P.J. (RNA 1999) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for TRNAU1AP Gene

Sources for TRNAU1AP Gene

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