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Aliases for TRNAU1AP Gene

Aliases for TRNAU1AP Gene

  • TRNA Selenocysteine 1 Associated Protein 1 2 3 5
  • TRNA Selenocysteine-Associated Protein 1 3 4
  • TRSPAP1 3 4
  • SECP43 3 4
  • TRNA Selenocysteine Associated Protein (SECP43) 3
  • TRNA Selenocysteine 1-Associated Protein 1 3
  • TRNA Selenocysteine Associated Protein 1 2
  • PRO1902 3

External Ids for TRNAU1AP Gene

Previous HGNC Symbols for TRNAU1AP Gene

  • TRSPAP1

Previous GeneCards Identifiers for TRNAU1AP Gene

  • GC01P028753
  • GC01P028879
  • GC01P027133

Summaries for TRNAU1AP Gene

GeneCards Summary for TRNAU1AP Gene

TRNAU1AP (TRNA Selenocysteine 1 Associated Protein 1) is a Protein Coding gene. Among its related pathways are Selenium Metabolism and Selenoproteins. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is C6orf52.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRNAU1AP Gene

Genomics for TRNAU1AP Gene

Regulatory Elements for TRNAU1AP Gene

Enhancers for TRNAU1AP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G028881 2 FANTOM5 Ensembl ENCODE dbSUPER 77.3 +332.2 332226 6.8 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 TRNAU1AP SNHG12 GMEB1 PHACTR4 TMEM200B ENSG00000237934 SNORA73B SNHG3 RAB42 DNAJC8
GH01G029236 1.4 FANTOM5 ENCODE 34.5 +685.7 685698 5.1 HDGF FOXA2 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 CBX5 ZNF207 TRNAU1AP SNHG12 TMEM200B PHACTR4 GMEB1 SNORA73B RAB42 SNHG3 ENSG00000237934 PTPRU
GH01G028647 1.2 ENCODE 34.2 +95.4 95429 2.7 CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 GMEB1 SNHG12 TRNAU1AP PHACTR4 SNORA73B SNHG3 ENSG00000237934 ENSG00000231344 RAB42 ENSG00000271398
GH01G028345 1.3 Ensembl ENCODE 29.3 -206.7 -206703 1.5 FOXA2 ATF1 ARNT ARID4B ZNF2 TCF12 GTF3C2 ZNF766 FOS KLF13 TRNAU1AP GMEB1 PHACTR4 SNHG3 SNORA73B SNHG12 ENSG00000237934 SESN2 RCC1 PRDX3P2
GH01G028258 1.4 ENCODE dbSUPER 24.8 -293.0 -293049 3.7 HDGF PKNOX1 CREB3L1 ARNT MLX SIN3A ARID4B YY1 ZNF766 ZNF416 SNHG12 TRNAU1AP ENSG00000270605 PHACTR4 DNAJC8 AHDC1 GMEB1 SNORA73B ACTG1P20 SNHG3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRNAU1AP on UCSC Golden Path with GeneCards custom track

Promoters for TRNAU1AP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000003883 183 1601 HDGF HNRNPUL1 PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZBTB7B

Genomic Location for TRNAU1AP Gene

Chromosome:
1
Start:
28,553,017 bp from pter
End:
28,578,545 bp from pter
Size:
25,529 bases
Orientation:
Plus strand

Genomic View for TRNAU1AP Gene

Genes around TRNAU1AP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRNAU1AP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRNAU1AP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRNAU1AP Gene

Proteins for TRNAU1AP Gene

  • Protein details for TRNAU1AP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX07-TSAP1_HUMAN
    Recommended name:
    tRNA selenocysteine 1-associated protein 1
    Protein Accession:
    Q9NX07
    Secondary Accessions:
    • Q86SU7

    Protein attributes for TRNAU1AP Gene

    Size:
    287 amino acids
    Molecular mass:
    D Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRNAU1AP Gene

Post-translational modifications for TRNAU1AP Gene

  • Ubiquitination at Lys127, isoforms=2137, Lys151, and Lys166
  • Modification sites at PhosphoSitePlus

Other Protein References for TRNAU1AP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for TRNAU1AP

No data available for DME Specific Peptides for TRNAU1AP Gene

Domains & Families for TRNAU1AP Gene

Gene Families for TRNAU1AP Gene

Protein Domains for TRNAU1AP Gene

Suggested Antigen Peptide Sequences for TRNAU1AP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRNAU1AP: view

No data available for UniProtKB/Swiss-Prot for TRNAU1AP Gene

Function for TRNAU1AP Gene

Gene Ontology (GO) - Molecular Function for TRNAU1AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA,IEA 22658674
genes like me logo Genes that share ontologies with TRNAU1AP: view
genes like me logo Genes that share phenotypes with TRNAU1AP: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRNAU1AP Gene

Localization for TRNAU1AP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRNAU1AP gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 3

Gene Ontology (GO) - Cellular Components for TRNAU1AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS,IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TRNAU1AP: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRNAU1AP Gene

Pathways & Interactions for TRNAU1AP Gene

genes like me logo Genes that share pathways with TRNAU1AP: view

Pathways by source for TRNAU1AP Gene

1 BioSystems pathway for TRNAU1AP Gene

Gene Ontology (GO) - Biological Process for TRNAU1AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001514 selenocysteine incorporation ISS,IEA --
GO:0006412 translation IEA --
genes like me logo Genes that share ontologies with TRNAU1AP: view

No data available for SIGNOR curated interactions for TRNAU1AP Gene

Transcripts for TRNAU1AP Gene

Unigene Clusters for TRNAU1AP Gene

TRNA selenocysteine 1 associated protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRNAU1AP Gene

No ASD Table

Relevant External Links for TRNAU1AP Gene

GeneLoc Exon Structure for
TRNAU1AP
ECgene alternative splicing isoforms for
TRNAU1AP

Expression for TRNAU1AP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRNAU1AP Gene

Protein differential expression in normal tissues from HIPED for TRNAU1AP Gene

This gene is overexpressed in Lymph node (25.5), Fetal ovary (11.3), Retina (9.2), and CD8 Tcells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRNAU1AP Gene



Protein tissue co-expression partners for TRNAU1AP Gene

NURSA nuclear receptor signaling pathways regulating expression of TRNAU1AP Gene:

TRNAU1AP

SOURCE GeneReport for Unigene cluster for TRNAU1AP Gene:

Hs.533626

Evidence on tissue expression from TISSUES for TRNAU1AP Gene

  • Nervous system(4.6)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with TRNAU1AP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRNAU1AP Gene

Orthologs for TRNAU1AP Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRNAU1AP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRNAU1AP 34 35
  • 99.74 (n)
oppossum
(Monodelphis domestica)
Mammalia TRNAU1AP 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRNAU1AP 34 35
  • 94.08 (n)
dog
(Canis familiaris)
Mammalia TRNAU1AP 34 35
  • 93.61 (n)
rat
(Rattus norvegicus)
Mammalia Trnau1ap 34
  • 93.38 (n)
mouse
(Mus musculus)
Mammalia Trnau1ap 34 16 35
  • 92.57 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TRNAU1AP 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRNAU1AP 34 35
  • 80.26 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 40 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11585 34
African clawed frog
(Xenopus laevis)
Amphibia secp43-prov 34
zebrafish
(Danio rerio)
Actinopterygii trnau1apb 34
  • 62.06 (n)
C19H6orf52 35
  • 47 (a)
OneToMany
wufa56b07 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3491 34
fruit fly
(Drosophila melanogaster)
Insecta CG15440 34 35
  • 54.65 (n)
worm
(Caenorhabditis elegans)
Secernentea T07F10.3 35
  • 15 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAM8 35 37
  • 12 (a)
ManyToMany
NGR1 35
  • 11 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 16 (a)
OneToMany
Species where no ortholog for TRNAU1AP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRNAU1AP Gene

ENSEMBL:
Gene Tree for TRNAU1AP (if available)
TreeFam:
Gene Tree for TRNAU1AP (if available)

Paralogs for TRNAU1AP Gene

Paralogs for TRNAU1AP Gene

genes like me logo Genes that share paralogs with TRNAU1AP: view

Variants for TRNAU1AP Gene

Sequence variations from dbSNP and Humsavar for TRNAU1AP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000011644 -- 28,563,041(+) CAGGC(A/C)CCTGC intron-variant
rs1000106582 -- 28,574,299(+) GCCAG(C/G)CTGGT intron-variant
rs1000177798 -- 28,555,160(+) GGGAG(A/G)CAGAG intron-variant
rs1000295474 -- 28,571,397(+) ACAGG(G/T)CATTC intron-variant
rs1000337433 -- 28,561,430(+) ACATA(A/G)GATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRNAU1AP Gene

Variant ID Type Subtype PubMed ID
dgv34e199 CNV deletion 23128226
esv3585588 CNV loss 21293372
nsv478111 CNV novel sequence insertion 20440878
nsv545916 CNV gain 21841781

Variation tolerance for TRNAU1AP Gene

Residual Variation Intolerance Score: 25.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRNAU1AP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRNAU1AP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRNAU1AP Gene

Disorders for TRNAU1AP Gene

Relevant External Links for TRNAU1AP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRNAU1AP

No disorders were found for TRNAU1AP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRNAU1AP Gene

Publications for TRNAU1AP Gene

  1. Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery. (PMID: 16230358) Xu X.M. … Hatfield D.L. (J. Biol. Chem. 2005) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Identification of a protein component of a mammalian tRNA(Sec) complex implicated in the decoding of UGA as selenocysteine. (PMID: 10606267) Ding F. … Grabowski P.J. (RNA 1999) 2 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64

Products for TRNAU1AP Gene

Sources for TRNAU1AP Gene

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