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Aliases for TRNAU1AP Gene

Aliases for TRNAU1AP Gene

  • TRNA Selenocysteine 1 Associated Protein 1 2 3
  • TRNA Selenocysteine Associated Protein 1 2 3
  • TRNA Selenocysteine-Associated Protein 1 3 4
  • TRSPAP1 3 4
  • SECP43 3 4
  • TRNA Selenocysteine Associated Protein (SECP43) 3
  • TRNA Selenocysteine 1-Associated Protein 1 3
  • PRO1902 3

External Ids for TRNAU1AP Gene

Previous HGNC Symbols for TRNAU1AP Gene

  • TRSPAP1

Previous GeneCards Identifiers for TRNAU1AP Gene

  • GC01P028753
  • GC01P028879
  • GC01P027133

Summaries for TRNAU1AP Gene

GeneCards Summary for TRNAU1AP Gene

TRNAU1AP (TRNA Selenocysteine 1 Associated Protein 1) is a Protein Coding gene. Among its related pathways are Selenium Metabolism and Selenoproteins. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is C6orf52.

UniProtKB/Swiss-Prot for TRNAU1AP Gene

  • Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRNAU1AP Gene

Genomics for TRNAU1AP Gene

Regulatory Elements for TRNAU1AP Gene

Genomic Location for TRNAU1AP Gene

Start:
28,553,017 bp from pter
End:
28,578,545 bp from pter
Size:
25,529 bases
Orientation:
Plus strand

Genomic View for TRNAU1AP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRNAU1AP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRNAU1AP Gene

Proteins for TRNAU1AP Gene

  • Protein details for TRNAU1AP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX07-TSAP1_HUMAN
    Recommended name:
    tRNA selenocysteine 1-associated protein 1
    Protein Accession:
    Q9NX07
    Secondary Accessions:
    • Q86SU7

    Protein attributes for TRNAU1AP Gene

    Size:
    287 amino acids
    Molecular mass:
    32499 Da
    Quaternary structure:
    • Component of the tRNA(Sec) complex composed at least of EEFSEC, SECISBP2, SEPHS1, SEPSECS, TRNAU1AP and tRNA(Sec). Found in a complex with tRNA(Sec). Interacts with SEPSECS. Associates with mRNP and/or polysomes (By similarity). Found in a complex with EEFSEC, SECISBP2, TRNAU1AP and tRNA(Sec).

    Three dimensional structures from OCA and Proteopedia for TRNAU1AP Gene

    Alternative splice isoforms for TRNAU1AP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRNAU1AP Gene

Proteomics data for TRNAU1AP Gene at MOPED

Post-translational modifications for TRNAU1AP Gene

  • Ubiquitination at Lys127, Lys137, Lys151, and Lys166
  • Modification sites at PhosphoSitePlus

Other Protein References for TRNAU1AP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRNAU1AP Gene

Domains for TRNAU1AP Gene

Gene Families for TRNAU1AP Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for TRNAU1AP Gene

Suggested Antigen Peptide Sequences for TRNAU1AP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NX07

UniProtKB/Swiss-Prot:

TSAP1_HUMAN :
  • Q9NX07
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the RRM TRSPAP family.
genes like me logo Genes that share domains with TRNAU1AP: view

Function for TRNAU1AP Gene

Molecular function for TRNAU1AP Gene

UniProtKB/Swiss-Prot Function: Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis (By similarity).

Gene Ontology (GO) - Molecular Function for TRNAU1AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0005515 protein binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with TRNAU1AP: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRNAU1AP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TRNAU1AP Gene

Localization for TRNAU1AP Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRNAU1AP Gene

Nucleus. Cytoplasm. Note=Abundant in the nucleus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRNAU1AP Gene COMPARTMENTS Subcellular localization image for TRNAU1AP gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TRNAU1AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TRNAU1AP: view

Pathways for TRNAU1AP Gene

genes like me logo Genes that share pathways with TRNAU1AP: view

Pathways by source for TRNAU1AP Gene

1 BioSystems pathway for TRNAU1AP Gene

Interacting Proteins for TRNAU1AP Gene

Gene Ontology (GO) - Biological Process for TRNAU1AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001514 selenocysteine incorporation ISS --
genes like me logo Genes that share ontologies with TRNAU1AP: view

Transcripts for TRNAU1AP Gene

Unigene Clusters for TRNAU1AP Gene

TRNA selenocysteine 1 associated protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRNAU1AP

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRNAU1AP Gene

No ASD Table

Relevant External Links for TRNAU1AP Gene

GeneLoc Exon Structure for
TRNAU1AP
ECgene alternative splicing isoforms for
TRNAU1AP

Expression for TRNAU1AP Gene

mRNA expression in normal human tissues for TRNAU1AP Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRNAU1AP Gene

SOURCE GeneReport for Unigene cluster for TRNAU1AP Gene Hs.533626

genes like me logo Genes that share expressions with TRNAU1AP: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRNAU1AP Gene

Orthologs for TRNAU1AP Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRNAU1AP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRNAU1AP 35
  • 99.74 (n)
  • 100 (a)
TRNAU1AP 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRNAU1AP 35
  • 94.08 (n)
  • 99.65 (a)
TRNAU1AP 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRNAU1AP 35
  • 93.61 (n)
  • 99.65 (a)
TRNAU1AP 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trnau1ap 35
  • 92.57 (n)
  • 98.95 (a)
Trnau1ap 16
Trnau1ap 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRNAU1AP 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRNAU1AP 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trnau1ap 35
  • 93.38 (n)
  • 99.3 (a)
chicken
(Gallus gallus)
Aves TRNAU1AP 35
  • 80.26 (n)
  • 93.38 (a)
TRNAU1AP 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 40 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia secp43-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11585 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3491 35
zebrafish
(Danio rerio)
Actinopterygii C19H6orf52 36
  • 47 (a)
OneToMany
trnau1apb 35
  • 62.06 (n)
  • 56.03 (a)
wufa56b07 35
fruit fly
(Drosophila melanogaster)
Insecta CG15440 35
  • 54.65 (n)
  • 52.33 (a)
CG15440 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T07F10.3 36
  • 15 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAM8 36
  • 12 (a)
ManyToMany
NAM8 38
NGR1 36
  • 11 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 16 (a)
OneToMany
Species with no ortholog for TRNAU1AP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRNAU1AP Gene

ENSEMBL:
Gene Tree for TRNAU1AP (if available)
TreeFam:
Gene Tree for TRNAU1AP (if available)

Paralogs for TRNAU1AP Gene

Paralogs for TRNAU1AP Gene

genes like me logo Genes that share paralogs with TRNAU1AP: view

Variants for TRNAU1AP Gene

Sequence variations from dbSNP and Humsavar for TRNAU1AP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4633256 -- 28,566,207(-) ctccc(A/G)agcag intron-variant
rs4654330 -- 28,575,626(+) cccag(A/C)taatt intron-variant
rs4654389 -- 28,561,855(+) atcac(A/G)aggtc intron-variant
rs4654394 -- 28,573,037(+) ttttc(C/T)ttttt intron-variant
rs6662008 -- 28,572,762(+) acccc(A/G)tctct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRNAU1AP Gene

Variant ID Type Subtype PubMed ID
dgv34e199 CNV Deletion 23128226

Relevant External Links for TRNAU1AP Gene

HapMap Linkage Disequilibrium report
TRNAU1AP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRNAU1AP Gene

Disorders for TRNAU1AP Gene

No disorders were found for TRNAU1AP Gene.

No data available for UniProtKB/Swiss-Prot for TRNAU1AP Gene

Publications for TRNAU1AP Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery. (PMID: 16230358) Xu X.M. … Hatfield D.L. (J. Biol. Chem. 2005) 2 3
  3. Supramolecular complexes mediate selenocysteine incorporation in vivo. (PMID: 16508009) Small-Howard A. … Berry M.J. (Mol. Cell. Biol. 2006) 3 4
  4. Identification of a protein component of a mammalian tRNA(Sec) complex implicated in the decoding of UGA as selenocysteine. (PMID: 10606267) Ding F. … Grabowski P.J. (RNA 1999) 2 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TRNAU1AP Gene

Sources for TRNAU1AP Gene

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