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TRNAU1AP Gene

protein-coding   GIFtS: 44
GCID: GC01P028879

TRNA Selenocysteine 1 Associated Protein 1

(Previous name: tRNA selenocysteine associated protein 1)
(Previous symbol: TRSPAP1)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TRNA Selenocysteine 1 Associated Protein 11 2     PRO19022
TRSPAP11 2 3     TRNA Selenocysteine 1-Associated Protein 12
TRNA Selenocysteine Associated Protein 11 2     TRNA Selenocysteine Associated Protein (SECP43)2
SECP432 3     SECp433
TRNA Selenocysteine-Associated Protein 12 3     

External Ids:    HGNC: 308131   Entrez Gene: 549522   Ensembl: ENSG000001800987   UniProtKB: Q9NX073   

Export aliases for TRNAU1AP gene to outside databases

Previous GC identifers: GC01P028753 GC01P027133


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TRNAU1AP Gene:
TRNAU1AP (tRNA selenocysteine 1 associated protein 1) is a protein-coding gene. Diseases associated with TRNAU1AP include diverticulitis. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is C6orf52.

UniProtKB/Swiss-Prot: TSAP1_HUMAN, Q9NX07
Function: Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps
resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2,
EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of
selenoproteins synthesis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRNAU1AP gene promoter:
         Max1   SRF   SRF (504 AA)   C/EBPalpha   CHOP-10   FOXJ2 (long isoform)   FOXJ2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRNAU1AP promoter sequence
   Search Chromatin IP Primers for TRNAU1AP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRNAU1AP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.3   Ensembl cytogenetic band:  1p35.3   HGNC cytogenetic band: 1p35.3

TRNAU1AP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRNAU1AP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P028879:  view genomic region     (about GC identifiers)

Start:
28,879,529 bp from pter      End:
28,905,057 bp from pter
Size:
25,529 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TSAP1_HUMAN, Q9NX07 (See protein sequence)
Recommended Name: tRNA selenocysteine 1-associated protein 1  
Size: 287 amino acids; 32499 Da
Subunit: Component of the tRNA(Sec) complex composed at least of EEFSEC, SECISBP2, SEPHS1, SEPSECS, TRNAU1AP and
tRNA(Sec). Found in a complex with tRNA(Sec). Interacts with SEPSECS. Associates with mRNP and/or polysomes (By
similarity). Found in a complex with EEFSEC, SECISBP2, TRNAU1AP and tRNA(Sec)
2 PDB 3D structures from and Proteopedia for TRNAU1AP:
2DHG (3D)        2DIV (3D)    
Secondary accessions: Q86SU7
Alternative splicing: 2 isoforms:  Q9NX07-1   Q9NX07-2   

Explore the universe of human proteins at neXtProt for TRNAU1AP: NX_Q9NX07

Explore proteomics data for TRNAU1AP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys127, Lys137, Lys151, Lys166
  • Modification sites at PhosphoSitePlus

  • See TRNAU1AP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060316.1  
    ENSEMBL proteins: 
     ENSP00000362936  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q9NX07

    ProtoNet protein and cluster: Q9NX07

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: TSAP1_HUMAN, Q9NX07
    Similarity: Belongs to the RRM TRSPAP family
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    TRNAU1AP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSAP1_HUMAN, Q9NX07
    Function: Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps
    resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2,
    EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of
    selenoproteins synthesis (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0005515protein binding ----
    GO:0044822poly(A) RNA binding IDA--
         
    TRNAU1AP for ontologies           About GeneDecksing


    Animal Models:
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TSAP1_HUMAN, Q9NX07: Nucleus (By similarity). Cytoplasm (By similarity). Note=Abundant in the nucleus (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm IEA--

    TRNAU1AP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TRNAU1AP About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Selenium Metabolism and Selenoproteins
    Selenium Metabolism and Selenoproteins


    1 BioSystems Pathway for TRNAU1AP
        Selenium Metabolism and Selenoproteins


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRNAU1AP
    Interactions:

        Search GeneGlobe Interaction Network for TRNAU1AP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRNAU1AP (ENSP000003629364) via UniProtKB, MINT, STRING, and/or I2D (see all 108)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CELA3BENSP000003383694STRING: ENSP00000338369
    ENSG00000228163ENSP000004062504STRING: ENSP00000406250
    SAMD13ENSP000003597074STRING: ENSP00000359707
    SRSF4ENSP000003629004STRING: ENSP00000362900
    SNRNP70ENSP000002214484STRING: ENSP00000221448
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001514selenocysteine incorporation ISS--

    TRNAU1AP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRNAU1AP (TSAP1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TRNAU1AP gene: 
    NM_017846.4  

    Unigene Cluster for TRNAU1AP:

    TRNA selenocysteine 1 associated protein 1
    Hs.533626  [show with all ESTs]
    Unigene Representative Sequence: NR_003109
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373830(uc001bqh.3 uc001bqi.3 uc010ofw.2) ENST00000495995
    ENST00000411406 ENST00000480930 ENST00000491577 ENST00000464880 ENST00000497790
    ENST00000495215 ENST00000464093 ENST00000484775
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate TRNAU1AP:
    hsa-miR-2355-3p
    SwitchGear 3'UTR luciferase reporter plasmidTRNAU1AP 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: TRNAU1AP (NM_017846)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRNAU1AP
      QuantiTect SYBR Green Assays in human, mouse, rat TRNAU1AP
      QuantiFast Probe-based Assays in human, mouse, rat TRNAU1AP

    Additional mRNA sequence: 

    AF118082.2 AK000510.1 AK300162.1 AK309481.1 BC000680.2 BC035855.1 BC039879.1 NR_003109.1 

    14 DOTS entries:

    DT.414053  DT.95110782  DT.95356565  DT.91679343  DT.70102738  DT.91913057  DT.121464485  DT.97857420 
    DT.100777906  DT.102821916  DT.121464493  DT.91742134  DT.121464486  DT.75190795 

    Selected AceView cDNA sequences (see all 123):

    BE896119 AK000510 AK023555 AI040387 BC035855 BE672225 CB149361 AF118082 
    AW593402 CR606491 AW167579 BQ014227 AW196757 BG250499 BC000680 T24005 
    AI890704 CB243904 T60861 CA309576 BM927394 CB321652 BQ014404 CD674303 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRNAU1AP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGCTCACT
    TRNAU1AP Expression
    About this image

    TRNAU1AP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRNAU1AP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.533626
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TRNAU1AP gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trnau1ap1 , 5 tRNA selenocysteine 1 associated protein 11, 5 92.57(n)1
    98.95(a)1
      4 (65.16 cM)5
    717871  NM_027925.31  NP_082201.21 
     1323117635 
    chicken
    (Gallus gallus)
    Aves TRNAU1AP1 tRNA selenocysteine 1 associated protein 1 80.26(n)
    93.38(a)
      419597  XM_004947726.1  XP_004947783.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    40(a)
    many ↔ many
    4(59170535-59182112)
    African clawed frog
    (Xenopus laevis)
    Amphibia secp43-prov2 tRNA selenocysteine associated protein 79.12(n)    BC056124.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa56b072 Danio rerio cDNA clone MGC77884 IMAGE6996630, complete more 73.42(n)    BC063993.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG154401 CG15440 54.65(n)
    52.33(a)
      33652  NM_134993.2  NP_608837.2 
    worm
    (Caenorhabditis elegans)
    Secernentea T07F10.36
    Protein T07F10.3 (T07F10.3) mRNA, complete cds
    15(a)
    1 → many
    V(12868026-12870035) WBGene00011589
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NAM8(YHR086W)4 RNA binding protein, component of the U1 snRNP protein; more   --   8(278153-279724) 856486  NP_011954.1 


    ENSEMBL Gene Tree for TRNAU1AP (if available)
    TreeFam Gene Tree for TRNAU1AP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRNAU1AP gene
    C6orf522  

    TRNAU1AP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRNAU1AP (see all 490)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1920258721,2
    --28877724(+) CTGGGC/TGCGAT 2 -- us2k10--------
    rs1850110981,2
    --28877804(+) TCGAGA/TCCAGC 2 -- us2k10--------
    rs1878195021,2
    --28877933(+) GGAGGC/TTAGAT 2 -- us2k10--------
    rs1915528791,2
    --28877972(+) ATTGCA/GCTCCA 2 -- us2k10--------
    rs1844240711,2
    --28878071(+) CATGAC/GCTTTG 2 -- us2k10--------
    rs1488307841,2
    --28878217(+) CTCCAA/CTGAAG 2 -- us2k10--------
    rs1897746461,2
    --28878297(+) AACAAC/TAGGGA 2 -- us2k10--------
    rs1434427321,2
    --28878308(+) GGTAGC/TGGAAC 2 -- us2k10--------
    rs1379769061,2
    C--28878411(+) GTGTT-/TGTGTGT 2 -- us2k10--------
    rs1929151091,2
    --28878625(+) ATTTTA/TAGTAG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TRNAU1AP (28879529 - 28905057 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TRNAU1AP:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv34e199CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRNAU1AP
    DNA2.0 Custom Variant and Variant Library Synthesis for TRNAU1AP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for TRNAU1AP:    About MalaCards
    diverticulitis


    TRNAU1AP for disorders           About GeneDecksing


    Export disorders for TRNAU1AP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRNAU1AP gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with TRNAU1AP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Supramolecular complexes mediate selenocysteine incorporation in vivo. (PubMed id 16508009)1, 2 Small-Howard A.... Berry M.J. (Mol. Cell. Biol. 2006)
    2. Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery. (PubMed id 16230358)1, 3 Xu X.M....Hatfield D.L. (J. Biol. Chem. 2005)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Identification of a protein component of a mammalian tRNA(Sec) complex implicated in the decoding of UGA as selenocysteine. (PubMed id 10606267)1, 3 Ding F. and Grabowski P.J. (RNA 1999)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    9. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    10. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54952 HGNC: 30813 AceView: SECP43 Ensembl:ENSG00000180098 euGenes: HUgn54952
    ECgene: TRNAU1AP H-InvDB: TRNAU1AP

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRNAU1AP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRNAU1AP gene:
    Search GeneIP for patents involving TRNAU1AP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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