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transfer RNA methionine 2 (anticodon CAU)(Previous name: transfer RNA methionine initiator 1 (anticodon CAU) )
(Previous symbols: TRM1, TRMI1, TRNAMI1)
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Aliases
for TRNAM2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Subcategory (RNA class): tRNA
Quality score for this RNA gene is 2
| Aliases |
|---|
| Transfer RNA Methionine 2 (Anticodon CAU)1 2 | | RNTMI22 5 | | TRM11 2 | | TRNAMI22 5 | | TRMI11 2 | | Transfer RNA Methionine Initiator 1 (Anticodon CAU)1 | | TRNAMI11 2 | | RNTMI2 |
| External Ids: | HGNC: 123221 | Entrez Gene: 72122 | OMIM: 1806205 |
Export aliases for TRNAM2 gene to outside databasesPrevious GC identifer: GC06U901442
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Summaries
for TRNAM2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TRNAM2:
Santos and Zasloff (1981) (PubMed 6261953) identified 12 initiator methionine tRNA genes, symbolized tRNA-i(met), inthe haploid human genome. Zasloff et al. (1982) (PubMed 6923137) found a variant tRNA-i(met) with a G-to-Ttransversion in the highly conserved TCGA sequence in loop 4, a sequence position occupied exclusively by a purine(usually G) in almost 200 prokaryotic and eukaryotic tRNAs. One functional consequence of this base substitution isreduction in the rate of processing of the primary transcript of the gene. A second, demonstrated by microinjectioninto the germinal vesicle of the intact Xenopus laevis oocyte, is blockage of egress from the nucleus. It has beenestimated that the human haploid genome contains 1,000 to 2,000 tRNA genes and that there are 50 to 60chromatographically distinct tRNA species. These observations suggest redundancy of some tRNA genes. The studies ofinitiator methionine tRNA genes bear out this suspicion.(supplied by OMIM, Sep 2009)
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Genomic Views
for TRNAM2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TRNAM2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRNAM2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRNAM2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p22.1 HGNC cytogenetic band: 6p22.1TRNAM2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P027745: view genomic region
(about GC identifiers)
Start:
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27,745,664 bp from pter |
End:
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27,745,735 bp from pter |
Size:
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72 bases |
Orientation:
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plus strand |
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Proteins
for TRNAM2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB: --
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Protein
Domains /
Families
for TRNAM2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| -- |
Function
for TRNAM2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Pathways & Interactions
for TRNAM2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRNAM2
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Drugs & Compounds
for TRNAM2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TRNAM2
Search CenterWatch for drugs/clinical trials and news about TRNAM2 
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Transcripts
for TRNAM2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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GeneLoc Exon Structure
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Expression
for TRNAM2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for TRNAM2:none
See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
SABiosciences Custom PCR Arrays for TRNAM2
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat TRNAM2 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRNAM2 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRNAM2 |
Orthologs
for TRNAM2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
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Paralogs
for TRNAM2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TRNAM2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for TRNAM2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TRNAM2 for disorders About MalaCards
TRNAM2 for disorders About GeneDecksing
OMIM gene information: 180620
OMIM disorders: --
Export disorders for TRNAM2 gene to outside databases
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Publications
for TRNAM2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for TRNAM2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TRNAM2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Comparative analysis of human chromosomal segments bearing nonallelic dispersed tRNAimet genes. (PubMed id 6261953)1, 3 Santos T. and Zasloff M. (1981)
- Two nonallelic tRNAiMet genes are located in the p23 leads to q12 region of human chromosome 6. (PubMed id 6308668)1 Naylor S.L....Zasloff M. (1983)
- Impaired nuclear transport of a human variant tRNAiMe t. (PubMed id 6923137)1 Zasloff M....Santos T. (1982)
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External Searches for TRNAM2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TRNAM2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing TRNAM2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TRNAM2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for TRNAM2 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for TRNAM2 gene:
Search GeneIP for patents involving TRNAM2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TRNAM2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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 |
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRNAM2 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRNAM2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRNAM2 | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRNAM2 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRNAM2 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRNAM2 |
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 |  |  |  | |
| | | | Search Tocris compounds for TRNAM2 |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for TRNAM2 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRNAM2 |
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