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Aliases for TRMT9B Gene

Aliases for TRMT9B Gene

  • TRNA Methyltransferase 9B (Putative) 2 3
  • KIAA1456 2 3 4 5
  • C8orf79 3 4
  • TRM9L 3 4
  • Probable TRNA Methyltransferase 9-Like Protein 3
  • Chromosome 8 Open Reading Frame 79 2
  • EC 2.1.1.- 4
  • HTRM9L 3

External Ids for TRMT9B Gene

Previous HGNC Symbols for TRMT9B Gene

  • C8orf79
  • KIAA1456

Summaries for TRMT9B Gene

GeneCards Summary for TRMT9B Gene

TRMT9B (TRNA Methyltransferase 9B (Putative)) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. An important paralog of this gene is ALKBH8.

UniProtKB/Swiss-Prot for TRMT9B Gene

  • May modifie wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9.

Additional gene information for TRMT9B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT9B Gene

Genomics for TRMT9B Gene

GeneHancer (GH) Regulatory Elements for TRMT9B Gene

Promoters and enhancers for TRMT9B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I012945 Promoter/Enhancer 1 EPDnew ENCODE 550.8 0.0 -32 0.2 CTBP1 RFX1 MNT ZIC2 TRMT9B GC08M012923 GC08M012922
GH08I012966 Promoter/Enhancer 0.7 EPDnew FANTOM5 566.7 +20.5 20535 0.2 TRMT9B LONRF1 LOC100422204 PIR63002
GH08I012972 Enhancer 0.8 Ensembl ENCODE 17.5 +26.8 26759 0.8 ZFHX2 POLR2A ZBTB11 KLF17 ZNF398 ZBTB20 ZNF423 EGR2 TRMT9B LOC100422204 PIR63002
GH08I013120 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.8 +182.2 182172 14.7 PKNOX1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF213 SP3 MXD4 REST DLC1 RNU6-842P RPS3AP34 ENSG00000255122 ALG1L12P LONRF1 TRMT9B LOC100421094 GC08P013101 GC08P013155
GH08I012977 Enhancer 0.8 FANTOM5 ENCODE 13.9 +31.3 31251 1 SOX5 SOX13 TFAP4 HLF SIN3A NR2F2 ZNF664 HNF1A POLR2A CTBP2 TRMT9B LOC100422204 PIR63002
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRMT9B on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRMT9B Gene

Genomic Locations for TRMT9B Gene
chr8:12,945,642-13,031,503
(GRCh38/hg38)
Size:
85,862 bases
Orientation:
Plus strand
chr8:12,803,151-12,889,012
(GRCh37/hg19)

Genomic View for TRMT9B Gene

Genes around TRMT9B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRMT9B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRMT9B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT9B Gene

Proteins for TRMT9B Gene

  • Protein details for TRMT9B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P272-K1456_HUMAN
    Recommended name:
    Probable tRNA methyltransferase 9-like protein
    Protein Accession:
    Q9P272
    Secondary Accessions:
    • Q96AW6

    Protein attributes for TRMT9B Gene

    Size:
    454 amino acids
    Molecular mass:
    51299 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA95980.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA95980.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRMT9B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRMT9B Gene

Post-translational modifications for TRMT9B Gene

No Post-translational modifications

No data available for DME Specific Peptides for TRMT9B Gene

Domains & Families for TRMT9B Gene

Gene Families for TRMT9B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TRMT9B Gene

Suggested Antigen Peptide Sequences for TRMT9B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P272

UniProtKB/Swiss-Prot:

K1456_HUMAN :
  • Belongs to the methyltransferase superfamily.
Family:
  • Belongs to the methyltransferase superfamily.
genes like me logo Genes that share domains with TRMT9B: view

Function for TRMT9B Gene

Molecular function for TRMT9B Gene

UniProtKB/Swiss-Prot Function:
May modifie wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9.

Enzyme Numbers (IUBMB) for TRMT9B Gene

Phenotypes From GWAS Catalog for TRMT9B Gene

Gene Ontology (GO) - Molecular Function for TRMT9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IBA --
GO:0008168 methyltransferase activity IEA --
GO:0008175 tRNA methyltransferase activity EXP 23381944
GO:0008198 ferrous iron binding IBA --
GO:0016300 tRNA (uracil) methyltransferase activity IBA --
genes like me logo Genes that share ontologies with TRMT9B: view
genes like me logo Genes that share phenotypes with TRMT9B: view

Animal Model Products

miRNA for TRMT9B Gene

miRTarBase miRNAs that target TRMT9B

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRMT9B Gene

Localization for TRMT9B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRMT9B gene
Compartment Confidence
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRMT9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm TAS --
genes like me logo Genes that share ontologies with TRMT9B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRMT9B Gene

Pathways & Interactions for TRMT9B Gene

genes like me logo Genes that share pathways with TRMT9B: view

Pathways by source for TRMT9B Gene

Gene Ontology (GO) - Biological Process for TRMT9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002098 tRNA wobble uridine modification IBA --
GO:0006400 tRNA modification TAS --
GO:0008033 tRNA processing IEA --
GO:0008152 metabolic process IEA --
GO:0030488 tRNA methylation IEA --
genes like me logo Genes that share ontologies with TRMT9B: view

No data available for SIGNOR curated interactions for TRMT9B Gene

Drugs & Compounds for TRMT9B Gene

No Compound Related Data Available

Transcripts for TRMT9B Gene

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT9B Gene

No ASD Table

Relevant External Links for TRMT9B Gene

GeneLoc Exon Structure for
TRMT9B
ECgene alternative splicing isoforms for
TRMT9B

Expression for TRMT9B Gene

NURSA nuclear receptor signaling pathways regulating expression of TRMT9B Gene:

TRMT9B

mRNA Expression by UniProt/SwissProt for TRMT9B Gene:

Q9P272-K1456_HUMAN
Tissue specificity: Down-regulated in breast, bladder, colorectal, cervix and testicular carcinomas.

Evidence on tissue expression from TISSUES for TRMT9B Gene

  • Eye(4)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with TRMT9B: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRMT9B Gene

Orthologs for TRMT9B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRMT9B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1456 34 33
  • 98.53 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA1456 34 33
  • 86.39 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA1456 34 33
  • 82.63 (n)
OneToOne
mouse
(Mus musculus)
Mammalia 6430573F11Rik 33 16 34
  • 79.34 (n)
rat
(Rattus norvegicus)
Mammalia RGD1304810 33
  • 78.85 (n)
oppossum
(Monodelphis domestica)
Mammalia KIAA1456 34
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1456 34
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA1456 34 33
  • 66.44 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA1456 34
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488302 33
  • 62.36 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:73340 34
  • 40 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG42261 34
  • 9 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C35D10.12 34
  • 27 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM9 34
  • 32 (a)
OneToMany
Species where no ortholog for TRMT9B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRMT9B Gene

ENSEMBL:
Gene Tree for TRMT9B (if available)
TreeFam:
Gene Tree for TRMT9B (if available)

Paralogs for TRMT9B Gene

Paralogs for TRMT9B Gene

genes like me logo Genes that share paralogs with TRMT9B: view

Variants for TRMT9B Gene

Sequence variations from dbSNP and Humsavar for TRMT9B Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000039370 -- 12,986,967(+) T/G genic_upstream_transcript_variant, intron_variant
rs1000041825 -- 13,010,522(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000057903 -- 12,986,150(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000108633 -- 12,983,455(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000151298 -- 12,957,793(+) C/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRMT9B Gene

Variant ID Type Subtype PubMed ID
dgv7083n100 CNV loss 25217958
dgv7084n100 CNV gain 25217958
esv2759594 CNV loss 17122850
esv3576525 CNV gain 25503493
esv3616295 CNV gain 21293372
nsv1017762 CNV loss 25217958
nsv1026381 CNV loss 25217958
nsv1030002 CNV loss 25217958
nsv1033244 CNV loss 25217958
nsv465469 CNV loss 19166990
nsv610406 CNV gain 21841781
nsv610409 CNV loss 21841781

Variation tolerance for TRMT9B Gene

Residual Variation Intolerance Score: 92.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.86; 58.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRMT9B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRMT9B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRMT9B Gene

Disorders for TRMT9B Gene

Additional Disease Information for TRMT9B

No disorders were found for TRMT9B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRMT9B Gene

Publications for TRMT9B Gene

  1. A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α. (PMID: 23381944) Begley U … Begley T (EMBO molecular medicine 2013) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. [Overexpression of KIAA1456 inhibits the proliferation of HO8910PM cells]. (PMID: 27609572) Chen H … Gao Y (Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 2016) 3 58

Products for TRMT9B Gene

Sources for TRMT9B Gene

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