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Aliases for TRMT61B Gene

Aliases for TRMT61B Gene

  • TRNA Methyltransferase 61B 2 3
  • TRNA Methyltransferase 61 Homolog B (S. Cerevisiae) 2
  • EC 2.1.1.220 4

External Ids for TRMT61B Gene

Previous GeneCards Identifiers for TRMT61B Gene

  • GC02M028926
  • GC02M029072

Summaries for TRMT61B Gene

GeneCards Summary for TRMT61B Gene

TRMT61B (TRNA Methyltransferase 61B) is a Protein Coding gene. GO annotations related to this gene include tRNA (adenine-N1-)-methyltransferase activity.

UniProtKB/Swiss-Prot for TRMT61B Gene

  • Methyltransferase that catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (decephering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (decephering codons UCA, UCU, UCG or UCC).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT61B Gene

Genomics for TRMT61B Gene

Regulatory Elements for TRMT61B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRMT61B Gene

Start:
28,849,821 bp from pter
End:
28,870,309 bp from pter
Size:
20,489 bases
Orientation:
Minus strand

Genomic View for TRMT61B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRMT61B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT61B Gene

Proteins for TRMT61B Gene

  • Protein details for TRMT61B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVS5-TR61B_HUMAN
    Recommended name:
    tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial
    Protein Accession:
    Q9BVS5
    Secondary Accessions:
    • Q9H0Q9
    • Q9NWS7

    Protein attributes for TRMT61B Gene

    Size:
    477 amino acids
    Molecular mass:
    52965 Da
    Quaternary structure:
    • Homooligomer; in contrast to TRMT61A, does not for a heterotetramer.

    Three dimensional structures from OCA and Proteopedia for TRMT61B Gene

neXtProt entry for TRMT61B Gene

Proteomics data for TRMT61B Gene at MOPED

Post-translational modifications for TRMT61B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRMT61B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRMT61B Gene

Domains for TRMT61B Gene

Protein Domains for TRMT61B Gene

Suggested Antigen Peptide Sequences for TRMT61B Gene

Graphical View of Domain Structure for InterPro Entry

Q9BVS5

UniProtKB/Swiss-Prot:

TR61B_HUMAN :
  • Q9BVS5
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
genes like me logo Genes that share domains with TRMT61B: view

No data available for Gene Families for TRMT61B Gene

Function for TRMT61B Gene

Molecular function for TRMT61B Gene

UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl-L-methionine + adenine(58) in tRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine(58) in tRNA.
UniProtKB/Swiss-Prot Function: Methyltransferase that catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (decephering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (decephering codons UCA, UCU, UCG or UCC).

Enzyme Numbers (IUBMB) for TRMT61B Gene

Gene Ontology (GO) - Molecular Function for TRMT61B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity --
GO:0005515 protein binding IPI 21903422
GO:0016429 tRNA (adenine-N1-)-methyltransferase activity IDA 23097428
genes like me logo Genes that share ontologies with TRMT61B: view

Animal Model Products

CRISPR Products

miRNA for TRMT61B Gene

miRTarBase miRNAs that target TRMT61B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRMT61B

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TRMT61B Gene

Localization for TRMT61B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRMT61B Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRMT61B Gene COMPARTMENTS Subcellular localization image for TRMT61B gene
Compartment Confidence
mitochondrion 5
cytosol 1
endoplasmic reticulum 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TRMT61B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 23097428
GO:0031515 tRNA (m1A) methyltransferase complex IBA --
genes like me logo Genes that share ontologies with TRMT61B: view

Pathways for TRMT61B Gene

SuperPathways for TRMT61B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRMT61B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process --
GO:0030488 tRNA methylation --
GO:0051260 protein homooligomerization IDA 23097428
GO:0070901 mitochondrial tRNA methylation IDA 23097428
genes like me logo Genes that share ontologies with TRMT61B: view

No data available for Pathways by source for TRMT61B Gene

Compounds for TRMT61B Gene

(1) HMDB Compounds for TRMT61B Gene

Compound Synonyms Cas Number PubMed IDs
S-Adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
29908-03-0
genes like me logo Genes that share compounds with TRMT61B: view

Transcripts for TRMT61B Gene

Unigene Clusters for TRMT61B Gene

TRNA methyltransferase 61 homolog B (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRMT61B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT61B Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5
SP1: -
SP2:
SP3: -
SP4: - -

Relevant External Links for TRMT61B Gene

GeneLoc Exon Structure for
TRMT61B
ECgene alternative splicing isoforms for
TRMT61B

Expression for TRMT61B Gene

mRNA expression in normal human tissues for TRMT61B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TRMT61B Gene

SOURCE GeneReport for Unigene cluster for TRMT61B Gene Hs.468026

genes like me logo Genes that share expressions with TRMT61B: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRMT61B Gene

Orthologs for TRMT61B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRMT61B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRMT61B 35
  • 99.72 (n)
  • 99.58 (a)
TRMT61B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRMT61B 35
  • 84.96 (n)
  • 76.14 (a)
dog
(Canis familiaris)
Mammalia TRMT61B 35
  • 81.48 (n)
  • 72.11 (a)
TRMT61B 36
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRMT61B 36
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRMT61B 36
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRMT61B 35
  • 63.32 (n)
  • 57.45 (a)
TRMT61B 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRMT61B 36
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.14744 35
trmt61b 35
  • 60.15 (n)
  • 55.84 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100003205 35
  • 54.71 (n)
  • 46.98 (a)
TRMT61B 36
  • 37 (a)
OneToOne
Species with no ortholog for TRMT61B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRMT61B Gene

ENSEMBL:
Gene Tree for TRMT61B (if available)
TreeFam:
Gene Tree for TRMT61B (if available)

Paralogs for TRMT61B Gene

No data available for Paralogs for TRMT61B Gene

Variants for TRMT61B Gene

Sequence variations from dbSNP and Humsavar for TRMT61B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs4233729 -- 28,869,813(+) ATCAG(C/T)TCCCC reference, synonymous-codon, nc-transcript-variant
rs4563180 -- 28,870,829(+) CGGTC(C/G)CCTCA upstream-variant-2KB
rs4632298 -- 28,853,416(+) AGCGA(C/T)CTGCC intron-variant
rs4638745 -- 28,870,937(+) CTCCC(A/G)AAACG upstream-variant-2KB
rs4665436 -- 28,867,361(+) AAATA(C/T)TGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRMT61B Gene

Variant ID Type Subtype PubMed ID
nsv819532 CNV Loss 19587683
nsv518751 CNV Gain 19592680
nsv817695 CNV Gain 17921354
esv29033 CNV Loss 19812545
esv2674264 CNV Deletion 23128226

Relevant External Links for TRMT61B Gene

HapMap Linkage Disequilibrium report
TRMT61B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRMT61B Gene

Disorders for TRMT61B Gene

No disorders were found for TRMT61B Gene.

No data available for UniProtKB/Swiss-Prot for TRMT61B Gene

Publications for TRMT61B Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  2. Trmt61B is a methyltransferase responsible for 1-methyladenosine at position 58 of human mitochondrial tRNAs. (PMID: 23097428) Chujo T. … Suzuki T. (RNA 2012) 2 3 4
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for TRMT61B Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TRMT61B
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TRMT61B
    • Block miRNA regulation of TRMT61B using miScript Target Protectors

    Sources for TRMT61B Gene

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