TRMT61B Gene
protein-coding GIFtS: 43
GCID: GC02M029072
|
|
tRNA methyltransferase 61 homolog B (S. cerevisiae)
| |
Aliases
for TRMT61B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TRNA Methyltransferase 61 Homolog B (S. Cerevisiae)1 2 | | FLJ206281 | | Potential TRNA (Adenine(58)-N(1))-Methyltransferase Catalytic Subunit TRMT61B2 | | Potential TRNA (Adenine-N(1)-)-Methyltransferase Catalytic Subunit TRMT61B2 | | TRNA (Adenine(58)-N(1))-Methyltransferase, Mitochondrial2 | | EC 2.1.1.2203 |
Export aliases for TRMT61B gene to outside databasesPrevious GC identifers: GC02M028926 GC02M028814 |
Summaries
for TRMT61B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TR61B_HUMAN, Q9BVS5Function: Methyltransferase that catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in various tRNAsin mitochondrion, including tRNA(Leu) (decephering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (decephering codonsUCA, UCU, UCG or UCC)
|
Genomic Views
for TRMT61B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TRMT61B gene promoter:
ATF-2 CUTL1 HNF-1A CREB POU2F1 POU2F1b POU2F1a deltaCREB HNF-1 POU2F1c
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRMT61B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRMT61B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p23.2 Ensembl cytogenetic band: 2p23.2 HGNC cytogenetic band: 2p23.2TRMT61B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M029072: view genomic region
(about GC identifiers)
Start:
|
29,072,687 bp from pter |
End:
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29,093,175 bp from pter |
Size:
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20,489 bases |
Orientation:
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minus strand |
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Proteins
for TRMT61B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TR61B_HUMAN, Q9BVS5 (See
protein sequence)Recommended Name: tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial precursor Size: 477 amino acids; 52965 Da
Subunit: Homooligomer; in contrast to TRMT61A, does not for a heterotetramer
Subcellular location: Mitochondrion
1 PDB 3D structure from  and Proteopedia  for TRMT61B:2B25 (3D)
Secondary accessions: Q9H0Q9 Q9NWS7Explore the universe of human proteins at neXtProt for TRMT61B: NX_Q9BVS5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BVS5
TRMT61B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060380.3
ENSEMBL proteins: ENSP00000405467 ENSP00000302801 ENSP00000389617
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IDA | -- | | GO:0031515 | tRNA (m1A) methyltransferase complex |
IEA | -- |
TRMT61B for ontologies About GeneDecksing
TRMT61B Antibody Products:
Assay Products for TRMT61B: |
Protein
Domains /
Families
for TRMT61B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRMT61B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BVS5ProtoNet protein and cluster: Q9BVS5 UniProtKB/Swiss-Prot: TR61B_HUMAN, Q9BVS5Similarity: Belongs to the methyltransferase superfamily. TRM61 family |
Function
for TRMT61B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TR61B_HUMAN, Q9BVS5Function: Methyltransferase that catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in various tRNAsin mitochondrion, including tRNA(Leu) (decephering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (decephering codonsUCA, UCU, UCG or UCC)Catalytic activity: S-adenosyl-L-methionine + adenine(58) in tRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine(58)in tRNAEnzyme Number (IUBMB): EC 2.1.1.2201
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT61B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT61B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for TRMT61B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRMT61B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT61B |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- | | GO:0016429 | tRNA (adenine-N1-)-methyltransferase activity |
IDA | -- |
TRMT61B for ontologies About GeneDecksing
|
Pathways & Interactions
for TRMT61B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRMT61B
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for TRMT61B (Q9BVS51, 3 ENSP000003028014) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0051260 | protein homooligomerization |
IDA | -- | | GO:0070901 | mitochondrial tRNA methylation |
IDA | -- |
TRMT61B for ontologies About GeneDecksing
|
Drugs & Compounds
for TRMT61B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TRMT61B
1 HMDB Compound for TRMT61B About this table
Search CenterWatch for drugs/clinical trials and news about TRMT61B / TR61B
|
Transcripts
for TRMT61B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TRMT61B gene: NM_017910.3 Unigene Cluster for TRMT61B: TRNA methyltransferase 61 homolog B (S. cerevisiae) Hs.468026 [show with all ESTs]Unigene Representative Sequence: AK2255515 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000419999 ENST00000306108(uc002rmm.3) ENST00000439947 ENST00000490390
ENST00000484060
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT61B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT61B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TRMT61B (NM_017910) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRMT61B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRMT61B |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRMT61B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TRMT61B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRMT61B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRMT61B |
Additional cDNA sequence: AK225551.1 AK308821.1 AL136689.1 BC000952.1 BC010365.1 15 DOTS entries: DT.100788641 DT.313043 DT.100712294 DT.97777029 DT.100788640 DT.40111965 DT.445619 DT.92437456 DT.100788644 DT.100806312 DT.92437458 DT.100788646 DT.120950900 DT.92062292 DT.95268879 24/141 AceView cDNA sequences (see all 141): BE463482 AA772380 AI950840 CR610767 AA778665 AA897336 AI624073 CR624779 BE645126 AA236489 AA581709 AA232694 AI285533 AI168370 AI333289 AW058577 CR620335 BF594793 CR612345 CD722020 N49604 BM720387 AI866119 AI016771
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for TRMT61B About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | |
| SP4: | | | | | | | - | | - | | | | | | | | | |
ECgene alternative splicing isoforms for TRMT61B
|
Expression
for TRMT61B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRMT61B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGAATCGCA
About this image
See TRMT61B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRMT61B
SOURCE GeneReport for Unigene cluster: Hs.468026
SABiosciences Custom PCR Arrays for TRMT61B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRMT61B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TRMT61B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRMT61B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRMT61B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT61B |
Orthologs
for TRMT61B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TRMT61B gene from 8/28 species (see all 28) About this table
ENSEMBL Gene Tree for TRMT61B (if available)
TreeFam Gene Tree for TRMT61B (if available) |
Paralogs
for TRMT61B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TRMT61B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TRMT61B (29072687 - 29093175 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for TRMT61B
2 CNVs: 9401 67308
1 Indel: 58979 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRMT61B |
|
Disorders
/ Diseases
for TRMT61B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TRMT61B for disorders About GeneDecksing
3  diseases for TRMT61B: About MalaCardshomocysteine tuberculosis mycobacterium tuberculosis
Export disorders for TRMT61B gene to outside databases
|
Publications
for TRMT61B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRMT61B gene integrated from 9 sources:
(articles sorted by number of sources associating them with TRMT61B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
- Trmt61B is a methyltransferase responsible for 1-methyladenosine at position 58 of human mitochondrial tRNAs. (PubMed id 23097428)1, 2 Chujo T. and Suzuki T. (2012)
- Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)
- Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
|
External Searches for TRMT61B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TRMT61B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRMT61B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TRMT61B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TRMT61B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TRMT61B gene:
Search GeneIP for patents involving TRMT61B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TRMT61B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for TRMT61B | | OriGene Custom Protein Services for TRMT61B | | | OriGene Custom Immunoassay Development | | |
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| |  |  |  |  | | | | |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT61B |
|  |  |  | | | | Search ThermoFisher Antibodies for TRMT61B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRMT61B |
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