Aliases for TRMT61A Gene
Aliases for TRMT61A Gene
- TRNA Methyltransferase 61A 2 3 5
- TRNA(M1A58)-Methyltransferase Subunit TRMT61A 3 4
- TRNA(M1A58)MTase Subunit TRMT61A 3 4
- C14orf172 3 4
- TRM61 3 4
- TRNA (Adenine-N(1)-)-Methyltransferase Catalytic Subunit TRMT61A 3
- TRNA (Adenine-N(1)-)-Methyltransferase Catalytic Subunit TRM61 3
- TRNA Methyltransferase 61 Homolog A (S. Cerevisiae) 2
- TRNA(M1A58)-Methyltransferase Subunit TRM61 3
External Ids for TRMT61A Gene
- HGNC: 23790
- Entrez Gene: 115708
- Ensembl: ENSG00000166166
- UniProtKB: Q96FX7
Previous HGNC Symbols for TRMT61A Gene
- C14orf172
Previous GeneCards Identifiers for TRMT61A Gene
- GC14P103067
- GC14P103995
- GC14P084173
Summaries for TRMT61A Gene
GeneCards Summary for TRMT61A Gene
TRMT61A (TRNA Methyltransferase 61A) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. GO annotations related to this gene include tRNA (adenine-N1-)-methyltransferase activity.
UniProtKB/Swiss-Prot for TRMT61A Gene
-
Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT61A Gene
Genomics for TRMT61A Gene
Regulatory Elements for TRMT61A Gene
Enhancers for TRMT61A Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around TRMT61A on UCSC Golden Path with GeneCards custom track
Promoters for TRMT61A Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around TRMT61A on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the TRMT61A gene promoter:
Regulatory Element Products
Genomic Location for TRMT61A Gene
- Chromosome:
- 14
- Start:
- 103,529,172 bp from pter
- End:
- 103,537,073 bp from pter
- Size:
- 7,902 bases
- Orientation:
- Plus strand
Genomic View for TRMT61A Gene
Genes around TRMT61A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q32.33 by Ensembl
- 14q32 by Entrez Gene
- 14q32 by HGNC
TRMT61A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TRMT61A Gene
Proteins for TRMT61A Gene
-
Protein details for TRMT61A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96FX7-TRM61_HUMAN
- Recommended name:
- tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A
- Protein Accession:
- Q96FX7
- A6NN78
- Q8N7Q9
Protein attributes for TRMT61A Gene
- Size:
- 289 amino acids
- Molecular mass:
- 31382 Da
- Quaternary structure:
-
- tRNA (adenine-N(1)-)-methyltransferase is a heterodimer of TRM6 and TRM61.
- SequenceCaution:
-
- Sequence=BAC05168.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
Protein Expression for TRMT61A Gene
Post-translational modifications for TRMT61A Gene
Other Protein References for TRMT61A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for TRMT61A
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- antibodies-online Antibodies for TRMT61A: See all 12
- GeneTex TRMT61A antibody for TRMT61A
-
Santa Cruz Biotechnology (SCBT) Antibodies for TRMT61A
Protein Products
-
OriGene Purified Proteins for TRMT61A
- Search Origene for MassSpec and Protein Over-expression Lysates for TRMT61A
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- antibodies-online Proteins for TRMT61A: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for TRMT61A
Assay Products
Domains & Families for TRMT61A Gene
Protein Domains for TRMT61A Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TRMT61A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96FX7UniProtKB/Swiss-Prot:
TRM61_HUMAN :- Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
- Family:
-
- Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
No data available for Gene Families for TRMT61A Gene
Function for TRMT61A Gene
Molecular function for TRMT61A Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- S-adenosyl-L-methionine + adenine(58) in tRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine(58) in tRNA.
- UniProtKB/Swiss-Prot Function:
- Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
Enzyme Numbers (IUBMB) for TRMT61A Gene
Phenotypes for TRMT61A Gene
- GenomeRNAi human phenotypes for TRMT61A:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability after Maraba virus infection
- Decreased influenza A/WSN/33 replication
- Decreased viability of wild-type and TP53 knockout cells
- Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers
- Decreased influenza A H1N1 (A/WSN/33) virus numbers
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for TRMT61A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TRMT61A gene
- Search ViGene Biosciences for TRMT61A
CRISPR Products
-
OriGene CRISPR knockouts for TRMT61A
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRMT61A
- GenScript: Design CRISPR guide RNA sequences for TRMT61A
miRNA for TRMT61A Gene
- miRTarBase miRNAs that target TRMT61A
miRNA Products
- Search ViGene Biosciences for TRMT61A
Clone Products
- OriGene clones in human for TRMT61A
- OriGene ORF clones in human,mouse,rat for TRMT61A
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for TRMT61A gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TRMT61A gene
-
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Flow Cytometry Products
No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRMT61A Gene
Localization for TRMT61A Gene
Subcellular locations from UniProtKB/Swiss-Prot for TRMT61A Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | TAS | -- |
Pathways & Interactions for TRMT61A Gene
More details on SuperPathways for TRMT61A| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | tRNA processing |
.55
|
|
| 2 | Gene Expression |
.49
|
Pathways by source for TRMT61A Gene
3 Reactome pathways for TRMT61A Gene
Interacting Proteins for TRMT61A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0030488 | tRNA methylation | IEA | -- |
No data available for SIGNOR curated interactions for TRMT61A Gene
Transcripts for TRMT61A Gene
mRNA/cDNA for TRMT61A Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (142) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TRMT61A Gene
CRISPR Products
-
OriGene CRISPR knockouts for TRMT61A
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRMT61A
- GenScript: Design CRISPR guide RNA sequences for TRMT61A
miRNA Products
- Search ViGene Biosciences for TRMT61A
Clone Products
- OriGene clones in human for TRMT61A
- OriGene ORF clones in human,mouse,rat for TRMT61A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | - |
Expression for TRMT61A Gene
This gene is overexpressed in Lung (30.3) and Breast (8.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRMT61A Gene
SOURCE GeneReport for Unigene cluster for TRMT61A Gene Hs.525610
Primer Products
-
OriGene qPCR primer pairs for TRMT61A
-
OriGene qPCR primer pairs and template standards for TRMT61A
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRMT61A Gene
Orthologs for TRMT61A Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | TRMT61A 35 |
|
||
| TRMT61A 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | TRMT61A 35 |
|
||
| TRMT61A 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Trmt61a 35 |
|
||
| Trmt61a 16 |
|
||||
| Trmt61a 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | TRMT61A 35 |
|
||
| TRMT61A 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Trmt61a 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TRMT61A 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | TRMT61A 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TRMT61A 35 |
|
||
| TRMT61A 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | TRMT61A 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.17346 35 |
|
||
| trmt61a 35 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC53312 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | trmt61a 35 |
|
||
| trmt61a 36 |
|
OneToOne | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003966 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG14544 35 |
|
||
| CG14544 36 |
|
OneToOne | |||
| worm (Caenorhabditis elegans) |
Secernentea | CELE_W02A11.1 35 |
|
||
| W02A11.1 36 |
|
OneToOne | |||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AFL214C 35 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E15225g 35 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | GCD14 35 |
|
||
| GCD14 36 |
|
OneToOne | |||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT5G14600 35 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os04g0326300 35 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.8067 35 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | cpd1 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
OneToOne |
- Species with no ortholog for TRMT61A:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for TRMT61A Gene
No data available for Paralogs for TRMT61A Gene
Variants for TRMT61A Gene
| SNP ID | Clin | Chr 14 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_026053 | - | ||||
| rs13967 | -- | 103,535,752(-) | CTTTA(A/G)GAGGT | utr-variant-3-prime | |
| rs1467561 | -- | 103,528,624(-) | CCCTG(A/G)CTGGG | upstream-variant-2KB | |
| rs2756119 | -- | 103,535,180(-) | TGCCC(C/T)CCTCC | utr-variant-3-prime | |
| rs2756126 | -- | 103,533,914(-) | TGAGG(C/T)TTGGT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv832883 | CNV | Loss | 17160897 |
| dgv1992n71 | CNV | Loss | 21882294 |
| nsv902300 | CNV | Loss | 21882294 |
| dgv1993n71 | CNV | Loss | 21882294 |
| dgv1994n71 | CNV | Loss | 21882294 |
| nsv827068 | CNV | Loss | 20364138 |
| nsv9170 | CNV | Gain | 18304495 |
Residual Variation Intolerance Score:
26.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.55;
11.80% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TRMT61A Gene
Disorders for TRMT61A Gene
Relevant External Links for TRMT61A
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- TRMT61A
No disorders were found for TRMT61A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRMT61A Gene
Publications for TRMT61A Gene
- The bipartite structure of the tRNA m1A58 methyltransferase from S. cerevisiae is conserved in humans. (PMID: 16043508) Ozanick S. … Anderson J.T. (RNA 2005) 2 3 4 67
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
- Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
- Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA(3)(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target. (PMID: 26470919) Finer-Moore J. … Stroud R.M. (J. Mol. Biol. 2015) 3
- Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
Products for TRMT61A Gene
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- OriGene qPCR primer pairs for TRMT61A
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- antibodies-online Antibodies for TRMT61A: See all 12
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- antibodies-online Proteins for TRMT61A: See all 5
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- GeneTex TRMT61A antibody for TRMT61A
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- ViGene Biosciences adenoviral particle packaged cDNA for TRMT61A gene
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Sources for TRMT61A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
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- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
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- (64) Nature
- (65) NCBI
- (66) OriGene
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- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
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- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
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- (107) COMPARTMENTS
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- (111) Addgene
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- (113) antibodies-online
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- (115) NONCODE
- (116) SwitchGear Genomics
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- (149) ENCODE
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