Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRMT61A Gene

protein-coding   GIFtS: 49
GCID: GC14P103995

TRNA Methyltransferase 61 Homolog A (S. Cerevisiae)

(Previous name: chromosome 14 open reading frame 172)
(Previous symbol: C14orf172)
  Search for TRMT61A
at
MalaCards
 

Aliases
for TRMT61A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
TRNA Methyltransferase 61 Homolog A (S. Cerevisiae)1 2     hTRM612
C14orf1721 2 3     TRNA (Adenine(58)-N(1))-Methyltransferase Catalytic Subunit TRMT61A2
TRM612 3     TRNA (Adenine-N(1)-)-Methyltransferase Catalytic Subunit TRM612
TRNA(M1A58)-Methyltransferase Subunit TRMT61A2 3     TRNA (Adenine-N(1)-)-Methyltransferase Catalytic Subunit TRMT61A2
TRNA(M1A58)MTase Subunit TRMT61A2 3     TRNA(M1A58)-Methyltransferase Subunit TRM612
Chromosome 14 Open Reading Frame 1721     TRNA(M1A58)MTase Subunit TRM612
GCD142     EC 2.1.1.2203
Gcd14p2     EC 2.1.1.368

External Ids:    HGNC: 237901   Entrez Gene: 1157082   Ensembl: ENSG000001661667   UniProtKB: Q96FX73   
ORGUL members:         
NONCODE14:n338528      

Export aliases for TRMT61A gene to outside databases

Previous GC identifers: GC14P103067 GC14P084173


Summaries
for TRMT61A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
GeneCards Summary for TRMT61A Gene: 
TRMT61A (tRNA methyltransferase 61 homolog A (S. cerevisiae)) is a protein-coding gene, and is affiliated with the lncRNA class. GO annotations related to this gene include tRNA (adenine-N1-)-methyltransferase activity.

UniProtKB/Swiss-Prot: TRM61_HUMAN, Q96FX7
Function: Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of
N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA




Genomic Views
for TRMT61A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRMT61A gene promoter:
         Max1   USF1   AP-2alpha isoform 3   USF-1:USF-2   AP-2alpha isoform 2   SRY   USF-1   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRMT61A promoter sequence
   Search SABiosciences Chromatin IP Primers for TRMT61A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRMT61A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32   Ensembl cytogenetic band:  14q32.32   HGNC cytogenetic band: 14q32

TRMT61A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRMT61A gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P103995:  view genomic region     (about GC identifiers)

Start:
 103,995,509 bp from pter      End:
 104,003,410 bp from pter
Size:
 7,902 bases      Orientation:
 plus strand

Proteins
for TRMT61A gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: TRM61_HUMAN, Q96FX7 (See protein sequence)
Recommended Name: tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A  
Size: 289 amino acids; 31382 Da
Subunit: tRNA (adenine-N(1)-)-methyltransferase is a heterodimer of TRM6 and TRM61
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=BAC05168.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Secondary accessions: A6NN78 Q8N7Q9

Explore the universe of human proteins at neXtProt for TRMT61A: NX_Q96FX7

Explore proteomics data for TRMT61A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96FX7

    • 3 DME Specific Peptides for TRMT61A (Q96FX7)
     LPHRTQI  PTPELWT  GHTGYLTFA 

    TRMT61A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRMT61A Protein Expression
    REFSEQ proteins: NP_689520.2  
    ENSEMBL proteins: 
     ENSP00000374399   ENSP00000299202  

    Human Recombinant Protein Products for TRMT61A: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TRMT61A
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TRMT61A
    GenScript Custom Purified and Recombinant Proteins Services for TRMT61A
    Novus Biologicals TRMT61A Protein
    Novus Biologicals TRMT61A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRMT61A 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0031515tRNA (m1A) methyltransferase complex IEA--

    TRMT61A for ontologies           About GeneDecksing



    TRMT61A Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TRMT61A
    GenScript Custom Superior Antibodies Services for TRMT61A
    Novus Biologicals TRMT61A Antibodies
    Abcam antibodies for TRMT61A
    Cloud-Clone Corp. Antibodies for TRMT61A 
    ThermoFisher Antibodies for TRMT61A
    LSBio Antibodies in human, mouse, rat for TRMT61A 

    Assay Products for TRMT61A: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TRMT61A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRMT61A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TRMT61A 
    Cloud-Clone Corp. CLIAs for TRMT61A

    Protein Domains /
    Families
    for TRMT61A gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 2 InterPro protein domains:
     IPR025809 tRNA_MeTrfase_GCD14_euk
     IPR014816 tRNA_MeTrfase_GCD14

    Graphical View of Domain Structure for InterPro Entry Q96FX7

    ProtoNet protein and cluster: Q96FX7

    UniProtKB/Swiss-Prot: TRM61_HUMAN, Q96FX7
    Similarity: Belongs to the methyltransferase superfamily. TRM61 family


    TRMT61A for domains           About GeneDecksing


    Function
    for TRMT61A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRM61_HUMAN, Q96FX7
    Function: Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of
    N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA
    Catalytic activity: S-adenosyl-L-methionine + adenine(58) in tRNA = S-adenosyl-L-homocysteine +
    N(1)-methyladenine(58) in tRNA

         Enzyme Numbers (IUBMB): EC 2.1.1.362 EC 2.1.1.2201

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016429tRNA (adenine-N1-)-methyltransferase activity IEA--
         
    TRMT61A for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for TRMT61A:
     Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Decreased viability of wild-ty 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRMT61A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRMT61A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRMT61A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRMT61A 

    miRNA
    Products:            		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRMT61A
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate TRMT61A:
    hsa-miR-1184 hsa-miR-4254 hsa-miR-544 hsa-miR-196a* hsa-miR-2355-3p hsa-miR-591 hsa-miR-608
    SwitchGear 3'UTR luciferase reporter plasmid: TRMT61A 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TRMT61A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRMT61A

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TRMT61A
    Sirion Biotech Customized adenovirus for overexpression of TRMT61A

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TRMT61A (see all 7)
    OriGene ORF clones in mouse, rat for TRMT61A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRMT61A (NM_152307)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRMT61A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRMT61A
    Sirion Biotech Customized lentivirus for stable overexpression of TRMT61A 
                         Customized lentivirus expression plasmids for stable overexpression of TRMT61A 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for TRMT61A
    Search LifeMap BioReagents cell lines for TRMT61A
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT61A


    Pathways & Interactions
    for TRMT61A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRMT61A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/48 Interacting proteins for TRMT61A (Q96FX73 ENSP000003743994) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DBR1Q9UK593, ENSP000002608034I2D: score=1 STRING: ENSP00000260803
    EIF2AK4Q9P2K83, ENSP000002637914I2D: score=1 STRING: ENSP00000263791
    FARS2O953633, ENSP000002746804I2D: score=1 STRING: ENSP00000274680
    MRTO4Q9UKD23, ENSP000003643204I2D: score=1 STRING: ENSP00000364320
    MTIF2P461993, ENSP000002636294I2D: score=1 STRING: ENSP00000263629
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030488tRNA methylation ----

    TRMT61A for ontologies           About GeneDecksing



    Drugs & Compounds
    for TRMT61A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRMT61A (TRM61)

    2 HMDB Compounds for TRMT61A    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--

    Search CenterWatch for drugs/clinical trials and news about TRMT61A / TRM61

    Transcripts
    for TRMT61A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TRMT61A gene: 
    NM_152307.2  

    Unigene Cluster for TRMT61A:

    TRNA methyltransferase 61 homolog A (S. cerevisiae)
    Hs.525610  [show with all ESTs]
    Unigene Representative Sequence: NM_152307
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000389749(uc001yng.3 uc010aws.3) ENST00000299202
    miRNA
    Products:             		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRMT61A
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate TRMT61A:
    hsa-miR-1184 hsa-miR-4254 hsa-miR-544 hsa-miR-196a* hsa-miR-2355-3p hsa-miR-591 hsa-miR-608
    SwitchGear 3'UTR luciferase reporter plasmid: TRMT61A 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TRMT61A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRMT61A
    Clone
    Products:             		 OriGene clones in human, mouse for TRMT61A (see all 7)
    OriGene ORF clones in mouse, rat for TRMT61A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRMT61A (NM_152307)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRMT61A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRMT61A
    Sirion Biotech Customized lentivirus for stable overexpression of TRMT61A 
                         Customized lentivirus expression plasmids for stable overexpression of TRMT61A 
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for TRMT61A
    OriGene qSTAR qPCR primer pairs in human, mouse for TRMT61A
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRMT61A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRMT61A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRMT61A

    Additional mRNA sequence: 

    BC007241.1 BC010167.2 BC016033.2 

    9 DOTS entries:

    DT.306574  DT.97840423  DT.100762946  DT.100772513  DT.100796595  DT.100833855  DT.75141547  DT.91761682 
    DT.120788522 

    24/142 AceView cDNA sequences (see all 142):

    AI573079 AI885413 CR625555 AA319355 CR616463 AI168476 BM698902 CR599923 
    BQ648018 CR624022 BQ950130 CR597205 BM669685 CR605570 BC010167 BE276214 
    CR620786 BE048174 AW196578 AA338075 AI668655 BX364005 BP357056 CF132455 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for TRMT61A    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
    SP1:                                    
    SP2:              -                     


    ECgene alternative splicing isoforms for TRMT61A

    Expression
    for TRMT61A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRMT61A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGAGGCCG
    TRMT61A Expression
    About this image


    See TRMT61A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRMT61A

    SOURCE GeneReport for Unigene cluster: Hs.525610
        SABiosciences Custom PCR Arrays for TRMT61A
    Primer
    Products:    		OriGene qPCR primer pairs and template standards for TRMT61A
    OriGene qSTAR qPCR primer pairs in human, mouse for TRMT61A
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRMT61A
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRMT61A
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRMT61A
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT61A

    Orthologs
    for TRMT61A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TRMT61A gene from 10/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Trmt61a1 , 5 tRNA methyltransferase 61 homolog A (S. cerevisiae)5
    tRNA methyltransferase 61A1    		 85.93(n)1
    91.35(a)1    		   12 (61.09 cM)5
    3281621  NM_001099792.11  NP_001093262.11 
     1116781055 
    chicken
    (Gallus gallus)    		 Aves TRMT61A1 tRNA methyltransferase 61 homolog A (S. cerevisiae) 66.67(n)
    70.76(a)    		   423481  XM_421386.3  XP_421386.3 
    lizard
    (Anolis carolinensis)    		 Reptilia TRMT61A6
    		 Uncharacterized protein
    		 68(a)
    		 1 ↔ 1
    		 GL343232.1(32338-90502)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC533122 hypothetical protein MGC53312 73.18(n)    BC042219.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii trmt61a1 tRNA methyltransferase 61 homolog A (S. cerevisiae) 65.73(n)
    70.63(a)    		   436593  NM_001002321.1  NP_001002321.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG145441 CG14544 55.36(n)
    51.05(a)    		   43170  NM_143204.3  NP_651461.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea CELE_W02A11.11 Protein W02A11.1 52.04(n)
    47.48(a)    		   173142  NM_060828.3  NP_493229.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes GCD141 Gcd14p 47.23(n)
    45.11(a)    		   853317   NP_012410.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G146001 tRNA (adenine-N1-)-methyltransferase 49.82(n)
    48.74(a)    		   831312  NM_121464.1  NP_568302.1 
    rice
    (Oryza sativa)    		 Liliopsida Os04g03263001 hypothetical protein 55.02(n)
    49.63(a)    		   4335490  NM_001059009.2  NP_001052474.2 


    ENSEMBL Gene Tree for TRMT61A (if available)
    TreeFam Gene Tree for TRMT61A (if available)

    Paralogs
    for TRMT61A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for TRMT61A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/226 SNPs in TRMT61A are shown (see all 226)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    VAR_0260534
    		----see VAR_0260532 V A mis40--------
    rs1830099301,2
    		--103993577(+) TCAATA/GAGATG 1 -- us2k10--------
    rs1446102281,2
    		C--103993826(+) GGAAA-/CCCACC 1 -- us2k10--------
    rs1421177781,2
    		--103993864(+) CCTTAA/TAGGCA 1 -- us2k10--------
    rs563248431,2
    		C,F--103993875(+) CCCGGC/ACCTGA 1 -- us2k13Minor allele frequency- A:0.22WA 122
    rs1851538971,2
    		--103993898(+) CACAGC/TTGAGA 1 -- us2k10--------
    rs1457113711,2
    		--103993938(+) GAAAGC/TCAGAA 1 -- us2k10--------
    rs1481033051,2
    		--103994074(+) GAGGCC/TGTAAG 1 -- us2k10--------
    rs1434402871,2
    		--103994112(+) GTGGT-/GGGCCC 1 -- us2k10--------
    rs1118350851,2
    		C--103994273(+) CAAGGG/ACCACA 1 -- us2k11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for TRMT61A (103995509 - 104003410 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for TRMT61A:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1992n71CNV Loss21882294
    nsv832883CNV Loss17160897
    dgv1993n71CNV Loss21882294
    nsv827068CNV Loss20364138
    nsv902300CNV Loss21882294
    dgv1994n71CNV Loss21882294
    nsv9170CNV Gain18304495

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TRMT61A
    DNA2.0 Custom Variant and Variant Library Synthesis for TRMT61A

    Disorders / Diseases
    for TRMT61A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for TRMT61A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRMT61A gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with TRMT61A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The bipartite structure of the tRNA m1A58 methyltransferase from S. cerevisiae is conserved in humans. (PubMed id 16043508)1, 2, 3 Ozanick S.... Anderson J.T. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The functional interactome landscape of the human hist one deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (2013)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    10. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)

    External Searches for TRMT61A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TRMT61A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 115708 HGNC: 23790 AceView: FLJ40452 Ensembl:ENSG00000166166 euGenes: HUgn115708
    ECgene: TRMT61A H-InvDB: TRMT61A

    Other Databases showing TRMT61A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TRMT61A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRMT61A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TRMT61A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TRMT61A gene:
    Search GeneIP for patents involving TRMT61A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for TRMT61A gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TRMT61A  
     OriGene qPCR primer pairs and template standards for TRMT61A   OriGene Protein Over-expression Lysate for TRMT61A  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TRMT61A  
     OriGene qSTAR qPCR primer pairs in human, mouse for TRMT61A   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TRMT61A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TRMT61A   OriGene Custom Protein Services for TRMT61A  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRMT61A
     QIAGEN SeqTarget long-range PCR primers for resequencing TRMT61A
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRMT61A
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRMT61A
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRMT61A
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRMT61A
     GenScript Custom Purified and Recombinant Proteins Services for TRMT61A GenScript cDNA clones with any tag delivered in your preferred vector for TRMT61A
     GenScript Custom Assay Services for TRMT61A GenScript Custom Superior Antibodies Services for TRMT61A
     GenScript Custom overexpressing Cell Line Services for TRMT61A CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TRMT61A promoter
     Search Chromatin IP Primers for TRMT61A
     RT2 qPCR Primer Assay in human, mouse, rat TRMT61A
     Search GNC Networks for TRMT61A
     SABiosciences Custom PCR Arrays for TRMT61A
     Search Tocris compounds for TRMT61A (TRM61)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TRMT61A antibodies
     TRMT61A proteins
     TRMT61A lysates
     Antibodies for TRMT61A
     See all of Abcam's Antibodies, Kits and Proteins for TRMT61A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for TRMT61A
     Antibodies for TRMT61A
     ELISAs for TRMT61A
     CLIAs for TRMT61A
     Search LifeMap BioReagents cell lines for TRMT61A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT61A
     SwitchGear 3'UTR luciferase reporter plasmids for TRMT61A
     SwitchGear Promoter luciferase reporter plasmids for TRMT61A
     ThermoFisher Antibodies for TRMT61A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRMT61A
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TRMT61A
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRMT61A
    Customized:
     lentivirus for stable overexpression of TRMT61A
     lentivirus expression plasmids for stable overexpression of TRMT61A
     adenovirus for overexpression of TRMT61A
     LSBio Antibodies in human, mouse, rat for TRMT61A
    		Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2014 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      TRMT61A gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4