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Aliases for TRMT61A Gene

Aliases for TRMT61A Gene

  • TRNA Methyltransferase 61A 2 3
  • TRNA(M1A58)-Methyltransferase Subunit TRMT61A 3 4
  • TRNA(M1A58)MTase Subunit TRMT61A 3 4
  • C14orf172 3 4
  • TRM61 3 4
  • TRNA (Adenine-N(1)-)-Methyltransferase Catalytic Subunit TRMT61A 3
  • TRNA (Adenine-N(1)-)-Methyltransferase Catalytic Subunit TRM61 3
  • TRNA Methyltransferase 61 Homolog A (S. Cerevisiae) 2
  • TRNA(M1A58)-Methyltransferase Subunit TRM61 3
  • Chromosome 14 Open Reading Frame 172 2
  • TRNA Methyltransferase 61 Homolog A 3
  • TRNA(M1A58)MTase Subunit TRM61 3
  • EC 2.1.1.220 4
  • EC 2.1.1.36 63
  • Gcd14p 3
  • HTRM61 3
  • GCD14 3

External Ids for TRMT61A Gene

Previous HGNC Symbols for TRMT61A Gene

  • C14orf172

Previous GeneCards Identifiers for TRMT61A Gene

  • GC14P103067
  • GC14P103995
  • GC14P084173

Summaries for TRMT61A Gene

GeneCards Summary for TRMT61A Gene

TRMT61A (TRNA Methyltransferase 61A) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA modification in the nucleus and cytosol. GO annotations related to this gene include tRNA (adenine-N1-)-methyltransferase activity.

UniProtKB/Swiss-Prot for TRMT61A Gene

  • Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT61A Gene

Genomics for TRMT61A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRMT61A Gene

Chromosome:
14
Start:
103,529,172 bp from pter
End:
103,537,073 bp from pter
Size:
7,902 bases
Orientation:
Plus strand

Genomic View for TRMT61A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRMT61A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT61A Gene

Proteins for TRMT61A Gene

  • Protein details for TRMT61A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FX7-TRM61_HUMAN
    Recommended name:
    tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A
    Protein Accession:
    Q96FX7
    Secondary Accessions:
    • A6NN78
    • Q8N7Q9

    Protein attributes for TRMT61A Gene

    Size:
    289 amino acids
    Molecular mass:
    31382 Da
    Quaternary structure:
    • tRNA (adenine-N(1)-)-methyltransferase is a heterodimer of TRM6 and TRM61.
    SequenceCaution:
    • Sequence=BAC05168.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

neXtProt entry for TRMT61A Gene

Proteomics data for TRMT61A Gene at MOPED

Selected DME Specific Peptides for TRMT61A Gene

Post-translational modifications for TRMT61A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRMT61A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for TRMT61A Gene

Protein Domains for TRMT61A Gene

Suggested Antigen Peptide Sequences for TRMT61A Gene

Graphical View of Domain Structure for InterPro Entry

Q96FX7

UniProtKB/Swiss-Prot:

TRM61_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
genes like me logo Genes that share domains with TRMT61A: view

No data available for Gene Families for TRMT61A Gene

Function for TRMT61A Gene

Molecular function for TRMT61A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + adenine(58) in tRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine(58) in tRNA.
UniProtKB/Swiss-Prot Function:
Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

Enzyme Numbers (IUBMB) for TRMT61A Gene

Gene Ontology (GO) - Molecular Function for TRMT61A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016429 contributes_to tRNA (adenine-N1-)-methyltransferase activity IBA --
genes like me logo Genes that share ontologies with TRMT61A: view
genes like me logo Genes that share phenotypes with TRMT61A: view

Animal Model Products

CRISPR Products

miRNA for TRMT61A Gene

miRTarBase miRNAs that target TRMT61A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRMT61A

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for TRMT61A Gene

Localization for TRMT61A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRMT61A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRMT61A Gene COMPARTMENTS Subcellular localization image for TRMT61A gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for TRMT61A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
GO:0031515 tRNA (m1A) methyltransferase complex IBA --
genes like me logo Genes that share ontologies with TRMT61A: view

Pathways & Interactions for TRMT61A Gene

genes like me logo Genes that share pathways with TRMT61A: view

Pathways by source for TRMT61A Gene

Gene Ontology (GO) - Biological Process for TRMT61A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006400 tRNA modification TAS --
GO:0008033 tRNA processing TAS --
GO:0010467 gene expression TAS --
GO:0030488 tRNA methylation IBA --
genes like me logo Genes that share ontologies with TRMT61A: view

No data available for SIGNOR curated interactions for TRMT61A Gene

Drugs & Compounds for TRMT61A Gene

(2) Drugs for TRMT61A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0
genes like me logo Genes that share compounds with TRMT61A: view

Transcripts for TRMT61A Gene

mRNA/cDNA for TRMT61A Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(142) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRMT61A Gene

TRNA methyltransferase 61 homolog A (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRMT61A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT61A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for TRMT61A Gene

GeneLoc Exon Structure for
TRMT61A
ECgene alternative splicing isoforms for
TRMT61A

Expression for TRMT61A Gene

mRNA expression in normal human tissues for TRMT61A Gene

Protein differential expression in normal tissues from HIPED for TRMT61A Gene

This gene is overexpressed in Lung (30.3) and Breast (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRMT61A Gene



SOURCE GeneReport for Unigene cluster for TRMT61A Gene Hs.525610

genes like me logo Genes that share expression patterns with TRMT61A: view

Protein tissue co-expression partners for TRMT61A Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRMT61A Gene

Orthologs for TRMT61A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRMT61A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRMT61A 35
  • 90.76 (n)
  • 95.44 (a)
TRMT61A 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRMT61A 35
  • 89.04 (n)
  • 94.81 (a)
TRMT61A 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trmt61a 35
  • 85.93 (n)
  • 91.35 (a)
Trmt61a 16
Trmt61a 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRMT61A 35
  • 99.08 (n)
  • 99.27 (a)
TRMT61A 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trmt61a 35
  • 86.85 (n)
  • 92.39 (a)
oppossum
(Monodelphis domestica)
Mammalia TRMT61A 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRMT61A 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRMT61A 35
  • 67.83 (n)
  • 72.13 (a)
TRMT61A 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRMT61A 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17346 35
trmt61a 35
  • 65.16 (n)
  • 69.69 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC53312 35
zebrafish
(Danio rerio)
Actinopterygii trmt61a 35
  • 65.73 (n)
  • 70.63 (a)
trmt61a 36
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003966 35
  • 54.78 (n)
  • 52.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14544 35
  • 55.17 (n)
  • 50.87 (a)
CG14544 36
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_W02A11.1 35
  • 53.93 (n)
  • 50.21 (a)
W02A11.1 36
  • 42 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL214C 35
  • 52.71 (n)
  • 48.29 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E15225g 35
  • 48.72 (n)
  • 44.44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GCD14 35
  • 46.95 (n)
  • 44.68 (a)
GCD14 36
  • 31 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G14600 35
  • 49.82 (n)
  • 48.74 (a)
rice
(Oryza sativa)
Liliopsida Os04g0326300 35
  • 55.02 (n)
  • 49.63 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8067 35
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cpd1 35
  • 45.69 (n)
  • 42.24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
OneToOne
Species with no ortholog for TRMT61A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRMT61A Gene

ENSEMBL:
Gene Tree for TRMT61A (if available)
TreeFam:
Gene Tree for TRMT61A (if available)

Paralogs for TRMT61A Gene

No data available for Paralogs for TRMT61A Gene

Variants for TRMT61A Gene

Sequence variations from dbSNP and Humsavar for TRMT61A Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs13967 -- 103,535,752(-) CTTTA(A/G)GAGGT utr-variant-3-prime
rs754287 -- 103,531,188(+) TGAAC(A/T)AGAGA intron-variant
rs754288 -- 103,531,078(+) TGTGG(C/T)GGGTG intron-variant
rs911552 -- 103,533,171(-) AGAGG(C/T)TTTGG intron-variant
rs911553 -- 103,533,139(-) CAGAC(C/T)CCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRMT61A Gene

Variant ID Type Subtype PubMed ID
nsv832883 CNV Loss 17160897
dgv1992n71 CNV Loss 21882294
nsv902300 CNV Loss 21882294
dgv1993n71 CNV Loss 21882294
dgv1994n71 CNV Loss 21882294
nsv827068 CNV Loss 20364138
nsv9170 CNV Gain 18304495

Variation tolerance for TRMT61A Gene

Residual Variation Intolerance Score: 26.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRMT61A Gene

HapMap Linkage Disequilibrium report
TRMT61A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRMT61A Gene

Disorders for TRMT61A Gene

Relevant External Links for TRMT61A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRMT61A
genes like me logo Genes that share disorders with TRMT61A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRMT61A Gene

Publications for TRMT61A Gene

  1. The bipartite structure of the tRNA m1A58 methyltransferase from S. cerevisiae is conserved in humans. (PMID: 16043508) Ozanick S. … Anderson J.T. (RNA 2005) 2 67
  2. GCD14p, a repressor of GCN4 translation, cooperates with Gcd10p and Lhp1p in the maturation of initiator methionyl-tRNA in Saccharomyces cerevisiae. (PMID: 10330157) Calvo O. … Tamame M. (Mol. Cell. Biol. 1999) 23 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  5. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 67

Products for TRMT61A Gene

Sources for TRMT61A Gene

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