TRMT61A Gene
protein-coding GIFtS: 48
GCID: GC14P103995
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tRNA methyltransferase 61 homolog A (S. cerevisiae)(Previous name: chromosome 14 open reading frame 172 ) (Previous symbol: C14orf172)
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Aliases for TRMT61A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
| This gene clusters with an RNA gene Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| TRNA Methyltransferase 61 Homolog A (S. Cerevisiae)1 2 | | Chromosome 14 Open Reading Frame 1721 | | C14orf1721 2 3 | | TRNA (Adenine(58)-N(1))-Methyltransferase Catalytic Subunit TRMT61A2 | | GCD141 2 | | TRNA (Adenine-N(1)-)-Methyltransferase Catalytic Subunit TRM612 | | Gcd14p1 2 | | TRNA (Adenine-N(1)-)-Methyltransferase Catalytic Subunit TRMT61A2 | | HTRM611 | | TRNA(M1A58)-Methyltransferase Subunit TRM612 | | TRM612 3 | | TRNA(M1A58)MTase Subunit TRM612 | | TRNA(M1A58)-Methyltransferase Subunit TRMT61A2 3 | | EC 2.1.1.2203 | | TRNA(M1A58)MTase Subunit TRMT61A2 3 | | EC 2.1.1.368 | | FLJ404521 | | |
| External Ids: | HGNC: 237901 | Entrez Gene: 1157082 | Ensembl: ENSG000001661667 | UniProtKB: Q96FX73 | | ORGUL members: | |
|---|
| NONCODE:n338528 | |
Export aliases for TRMT61A gene to outside databasesPrevious GC identifers: GC14P103067 GC14P084173
Summaries for TRMT61A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: TRM61_HUMAN, Q96FX7Function: Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation ofN(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA
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Genomic Views for TRMT61A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TRMT61A gene promoter: Max1 USF1 AP-2alpha isoform 3 USF-1:USF-2 AP-2alpha isoform 2 SRY USF-1 AP-2alpha isoform 4 AP-2alpha AP-2alphaA Other transcription factors
Search SABiosciences Chromatin IP Primers for TRMT61A
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRMT61A |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q32 Ensembl cytogenetic band: 14q32.32 HGNC cytogenetic band: 14q32TRMT61A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P103995: view genomic region
(about GC identifiers)
Start:
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103,995,509 bp from pter |
End:
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104,003,410 bp from pter |
Size:
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7,902 bases |
Orientation:
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plus strand |
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Proteins for TRMT61A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: TRM61_HUMAN, Q96FX7 (See
protein sequence)Recommended Name: tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A Size: 289 amino acids; 31382 Da
Subunit: tRNA (adenine-N(1)-)-methyltransferase is a heterodimer of TRM6 and TRM61
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=BAC05168.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Secondary accessions: A6NN78 Q8N7Q9Explore the universe of human proteins at neXtProt for TRMT61A: NX_Q96FX7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96FX7 3 DME Specific Peptides for TRMT61A (Q96FX7)
TRMT61A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689520.2 ENSEMBL proteins: ENSP00000374399 ENSP00000299202 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | | GO:0031515 | tRNA (m1A) methyltransferase complex |
IEA | -- |
TRMT61A for ontologies About GeneDecksing
TRMT61A Antibody Products: Assay Products for TRMT61A: |
Protein
Domains / Families for TRMT61A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRMT61A for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96FX7ProtoNet protein and cluster: Q96FX7 UniProtKB/Swiss-Prot: TRM61_HUMAN, Q96FX7Similarity: Belongs to the methyltransferase superfamily. TRM61 family |
Function for TRMT61A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: TRM61_HUMAN, Q96FX7Function: Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation ofN(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNACatalytic activity: S-adenosyl-L-methionine + adenine(58) in tRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine(58)in tRNAEnzyme Numbers (IUBMB): EC 2.1.1.362 EC 2.1.1.2201
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT61A (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT61A (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TRMT61A (NM_152307) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRMT61A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRMT61A  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT61A |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016429 | tRNA (adenine-N1-)-methyltransferase activity |
IEA | -- |
TRMT61A for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for TRMT61A:
|
Pathways & Interactions for TRMT61A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRMT61A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 23)
 5/47 Interacting proteins for TRMT61A (Q96FX73 ENSP000003743994) via UniProtKB, MINT, STRING, and/or I2D (see all 47)About this table
|
Drugs & Compounds for TRMT61A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for TRMT61A
2 HMDB Compounds for TRMT61A About this table Search CenterWatch for drugs/clinical trials and news about TRMT61A / TRM61 
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Transcripts for TRMT61A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for TRMT61A gene: NM_152307.2 Unigene Cluster for TRMT61A: TRNA methyltransferase 61 homolog A (S. cerevisiae) Hs.525610 [show with all ESTs]Unigene Representative Sequence: NM_1523072 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000389749(uc001yng.3 uc010aws.3) ENST00000299202
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT61A (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT61A (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TRMT61A (NM_152307) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRMT61A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRMT61A  |
Additional cDNA sequence: BC007241.1 BC010167.2 BC016033.2 9 DOTS entries: DT.306574 DT.97840423 DT.100762946 DT.100772513 DT.100796595 DT.100833855 DT.75141547 DT.91761682 DT.120788522 24/142 AceView cDNA sequences (see all 142): CR599923 BM669685 CR625555 AW196578 BE276214 BQ648018 BQ950130 CR597205 AI885413 BE048174 BC010167 BM698902 CR605570 AA319355 CR620786 AI168476 CR616463 CR624022 AA338075 AI668655 AI573079 BX350653 BM926457 BM805254 GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for TRMT61A About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | |
| SP1: | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | |   | |   | |   |
ECgene alternative splicing isoforms for TRMT61A
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Expression for TRMT61A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRMT61A expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: AAGGAGGCCG
About this image See TRMT61A Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TRMT61A
SOURCE GeneReport for Unigene cluster: Hs.525610 SABiosciences Custom PCR Arrays for TRMT61A
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRMT61A Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRMT61A | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRMT61A | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRMT61A | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT61A |
Orthologs for TRMT61A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TRMT61A gene from 10/36 species (see all 36) About this table
ENSEMBL Gene Tree for TRMT61A (if available) TreeFam Gene Tree for TRMT61A (if available)  |
Paralogs for TRMT61A gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for TRMT61A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 14 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for TRMT61A (103995509 - 104003410 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for TRMT61A 1 CNV: 30663  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRMT61A |
|
Disorders
/ Diseases for TRMT61A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TRMT61A for disorders About GeneDecksing
3 diseases for TRMT61A: About MalaCardshomocysteine tuberculosis malaria Export disorders for TRMT61A gene to outside databases
|
Publications for TRMT61A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRMT61A gene, integrated from 9 sources (see all 13): (articles sorted by number of sources associating them with TRMT61A) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The bipartite structure of the tRNA m1A58 methyltransferase from S. cerevisiae is conserved in humans. (PubMed id 16043508)1, 2, 3 Ozanick S.... Anderson J.T. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
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External Searches for TRMT61A gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing TRMT61A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRMT61A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TRMT61A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for TRMT61A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TRMT61A gene: Search GeneIP for patents involving TRMT61A
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for TRMT61A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
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 |  |  |  | |
| | | Search Tocris compounds for TRMT61A |
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 | | TRMT61A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT61A |
|  |  |  | | | Search ThermoFisher Antibodies for TRMT61A |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRMT61A |
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