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TRMT61A Gene

protein-coding GIFtS: 50
GCID: GC14P103995

TRNA Methyltransferase 61 Homolog A (S. Cerevisiae)

(Previous name: chromosome 14 open reading frame 172)
(Previous symbol: C14orf172)

See related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
TRNA Methyltransferase 61 Homolog A (S. Cerevisiae)¹ ²		hTRM61²
C14orf172¹ ² ³		TRNA (Adenine(58)-N(1))-Methyltransferase Catalytic Subunit TRMT61A²
TRM61² ³		TRNA (Adenine-N(1)-)-Methyltransferase Catalytic Subunit TRM61²
TRNA(M1A58)-Methyltransferase Subunit TRMT61A² ³		TRNA (Adenine-N(1)-)-Methyltransferase Catalytic Subunit TRMT61A²
TRNA(M1A58)MTase Subunit TRMT61A² ³		TRNA(M1A58)-Methyltransferase Subunit TRM61²
Chromosome 14 Open Reading Frame 172¹		TRNA(M1A58)MTase Subunit TRM61²
GCD14²		EC 2.1.1.220³
Gcd14p²		EC 2.1.1.36⁸

External Ids:	HGNC: 23790¹	Entrez Gene: 115708²	Ensembl: ENSG00000166166⁷	UniProtKB: Q96FX7³

Export aliases for TRMT61A gene to outside databases

Previous GC identifers: GC14P103067 GC14P084173

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TRMT61A Gene:

TRMT61A (tRNA methyltransferase 61 homolog A (S. cerevisiae)) is a protein-coding gene. Diseases associated with TRMT61A include malaria. GO annotations related to this gene include tRNA (adenine-N1-)-methyltransferase activity.

UniProtKB/Swiss-Prot: TRM61_HUMAN, Q96FX7

Function: Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of

N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000014.9 NC_018925.2 NT_026437.13

Regulatory elements:

Regulatory transcription factor binding sites in the TRMT61A gene promoter:
Max1 USF1 AP-2alpha isoform 3 USF-1:USF-2 AP-2alpha isoform 2 SRY USF-1 AP-2alpha isoform 4 AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRMT61A promoter sequence

Search Chromatin IP Primers for TRMT61A

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRMT61A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32 Ensembl cytogenetic band: 14q32.32 HGNC cytogenetic band: 14q32

TRMT61A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRMT61A gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P103995: view genomic region (about GC identifiers)

Start:	103,995,509 bp from pter	End:	104,003,410 bp from pter
Size:	7,902 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TRM61_HUMAN, Q96FX7 (See protein sequence)

Recommended Name: tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A

Size: 289 amino acids; 31382 Da

Subunit: tRNA (adenine-N(1)-)-methyltransferase is a heterodimer of TRM6 and TRM61

Sequence caution: Sequence=BAC05168.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;

Secondary accessions: A6NN78 Q8N7Q9

Explore the universe of human proteins at neXtProt for TRMT61A: NX_Q96FX7

Explore proteomics data for TRMT61A at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

3 DME Specific Peptides for TRMT61A (Q96FX7)

LPHRTQI

PTPELWT

GHTGYLTFA

See TRMT61A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_689520.2

ENSEMBL proteins:

ENSP00000374399 ENSP00000299202

TRMT61A Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:

IPR014816 tRNA_MeTrfase_Gcd14

Graphical View of Domain Structure for InterPro Entry Q96FX7

ProtoNet protein and cluster: Q96FX7

UniProtKB/Swiss-Prot: TRM61_HUMAN, Q96FX7

Similarity: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family

TRMT61A for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: TRM61_HUMAN, Q96FX7

Function: Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of

N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA

Catalytic activity: S-adenosyl-L-methionine + adenine(58) in tRNA = S-adenosyl-L-homocysteine +

N(1)-methyladenine(58) in tRNA

Enzyme Numbers (IUBMB): EC 2.1.1.36² EC 2.1.1.220¹

Gene Ontology (GO): 1 molecular function term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016429	tRNA (adenine-N1-)-methyltransferase activity	IEA	--

TRMT61A for ontologies About GeneDecksing

Phenotypes:
4 GenomeRNAi human phenotypes for TRMT61A:

Decreased influenza A H1N1 (A/

Decreased influenza A/WSN/33 r

Decreased viability of wild-ty

Animal Models:

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genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRMT61A

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRMT61A

miRNA Products:		miRTarBase miRNAs that target TRMT61A: hsa-mir-92a-3p (MIRT049081), hsa-mir-342-3p (MIRT043665), hsa-mir-769-5p (MIRT039179)

		Block miRNA regulation of human, mouse, rat TRMT61A using miScript Target Protectors
		7 qRT-PCR Assays for microRNAs that regulate TRMT61A:
		hsa-miR-1184 hsa-miR-4254 hsa-miR-544 hsa-miR-196a* hsa-miR-2355-3p hsa-miR-591 hsa-miR-608
		SwitchGear 3'UTR luciferase reporter plasmid: TRMT61A 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TRMT61A
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT61A

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

TRM61_HUMAN, Q96FX7: Nucleus (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	2
cytosol	1
extracellular	1
mitochondrion	1
peroxisome	1

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Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0031515	tRNA (m1A) methyltransferase complex	IEA	--

TRMT61A for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for TRMT61A
Interactions:

Search GeneGlobe Interaction Network for TRMT61A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for TRMT61A (Q96FX7³ ENSP00000374399⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 76)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DDX55	Q8NHQ9³, ENSP00000238146⁴	I2D: score=1 STRING: ENSP00000238146
EIF2AK4	Q9P2K8³, ENSP00000263791⁴	I2D: score=1 STRING: ENSP00000263791
FARS2	O95363³, ENSP00000274680⁴	I2D: score=1 STRING: ENSP00000274680
FKBP1A	P62942³, ENSP00000371138⁴	I2D: score=1 STRING: ENSP00000371138
MRTO4	Q9UKD2³, ENSP00000364320⁴	I2D: score=1 STRING: ENSP00000364320

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Gene Ontology (GO): 1 biological process term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030488	tRNA methylation	--	--

TRMT61A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for TRMT61A (TRM61)

2 HMDB Compounds for TRMT61A About this table

Compound	Synonyms	CAS #	PubMed Ids
S-Adenosylhomocysteine	(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)	979-92-0	--
S-Adenosylmethionine	(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)	29908-03-0	--

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for TRMT61A gene:

NM_152307.2

Unigene Cluster for TRMT61A:

TRNA methyltransferase 61 homolog A (S. cerevisiae)

Hs.525610 [show with all ESTs]

Unigene Representative Sequence: NM_152307

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000389749(uc001yng.3 uc010aws.3) ENST00000299202

miRNA Products:		Block miRNA regulation of human, mouse, rat TRMT61A using miScript Target Protectors
		7 qRT-PCR Assays for microRNAs that regulate TRMT61A:
		hsa-miR-1184 hsa-miR-4254 hsa-miR-544 hsa-miR-196a* hsa-miR-2355-3p hsa-miR-591 hsa-miR-608
		SwitchGear 3'UTR luciferase reporter plasmid: TRMT61A 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TRMT61A
		Predesigned siRNA for gene silencing in human, mouse, rat TRMT61A

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		GenScript: all cDNA clones in your preferred vector: TRMT61A (NM_152307)
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Primer Products:		OriGene qPCR primer pairs and template standards for TRMT61A OriGene qSTAR qPCR primer pairs in human, mouse for TRMT61A
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		QuantiTect SYBR Green Assays in human, mouse, rat TRMT61A
		QuantiFast Probe-based Assays in human, mouse, rat TRMT61A

Additional mRNA sequence:

BC007241.1 BC010167.2 BC016033.2

9 DOTS entries:

DT.306574 DT.97840423 DT.100762946 DT.100772513 DT.100796595 DT.100833855 DT.75141547 DT.91761682

DT.120788522

Selected AceView cDNA sequences (see all 142):

BQ648018 BE276214 AW196578 AA338075 BC010167 BM669685 CR620786 BE048174

CR624022 CR605570 CR599923 BM698902 AA319355 CR625555 AI168476 BQ950130

AI573079 AI885413 CR597205 AI668655 CR616463 BX361326 BG478727 AI734254

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for TRMT61A About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b
SP1:
SP2:					-

ECgene alternative splicing isoforms for TRMT61A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TRMT61A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AAGGAGGCCG

About this image

TRMT61A Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

TRMT61A Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.525610

Custom PCR Arrays for TRMT61A

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT61A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for TRMT61A gene from Selected species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Trmt61a^{1 , 5}	tRNA methyltransferase 61 homolog A (S. cerevisiae)⁵ tRNA methyltransferase 61A¹	85.93(n)¹ 91.35(a)¹		12 (61.09 cM)⁵ 328162¹ NM_001099792.1¹ NP_001093262.1¹ 111678105⁵
chicken (Gallus gallus)	Aves	TRMT61A¹	tRNA methyltransferase 61 homolog A (S. cerevisiae)	67.83(n) 72.13(a)		423481 XM_421386.4 XP_421386.4
lizard (Anolis carolinensis)	Reptilia	TRMT61A⁶	tRNA methyltransferase 61 homolog A (S. cerevisiae...	67(a)	1 ↔ 1	GL343232.1(32338-90502)
African clawed frog (Xenopus laevis)	Amphibia	MGC53312²	hypothetical protein MGC53312	73.18(n)		BC042219.1
zebrafish (Danio rerio)	Actinopterygii	trmt61a¹	tRNA methyltransferase 61 homolog A (S. cerevisiae)	65.73(n) 70.63(a)		436593 NM_001002321.1 NP_001002321.1
fruit fly (Drosophila melanogaster)	Insecta	CG14544¹	CG14544	55.17(n) 50.87(a)		43170 NM_143204.3 NP_651461.1
worm (Caenorhabditis elegans)	Secernentea	CELE_W02A11.1¹	CELE_W02A11.1	53.93(n) 50.21(a)		173142 NM_060828.4 NP_493229.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	GCD14¹	GCD14	46.95(n) 44.68(a)		853317 NP_012410.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G14600¹	AT5G14600	49.82(n) 48.74(a)		831312 NM_121464.1 NP_568302.1
rice (Oryza sativa)	Liliopsida	Os04g0326300¹	Os04g0326300	55.02(n) 49.63(a)		4335490 NM_001059009.2 NP_001052474.2

ENSEMBL Gene Tree for TRMT61A (if available)
TreeFam Gene Tree for TRMT61A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183009930^1,2		--	103993577(+)	`TCAATA/GAGATG`	1	--	us2k¹		0	--	--	--	--
rs144610228^1,2	C	--	103993826(+)	`GGAAA-/CCCACC`	1	--	us2k¹		0	--	--	--	--
rs142117778^1,2		--	103993864(+)	`CCTTAA/TAGGCA`	1	--	us2k¹		0	--	--	--	--
rs56324843^1,2	C,F	--	103993875(+)	`CCCGGC/ACCTGA`	1	--	us2k¹		3		WA	122
rs185153897^1,2		--	103993898(+)	`CACAGC/TTGAGA`	1	--	us2k¹		0	--	--	--	--
rs145711371^1,2		--	103993938(+)	`GAAAGC/TCAGAA`	1	--	us2k¹		0	--	--	--	--
rs148103305^1,2		--	103994074(+)	`GAGGCC/TGTAAG`	1	--	us2k¹		0	--	--	--	--
rs143440287^1,2		--	103994112(+)	`GTGGT-/GGGCCC`	1	--	us2k¹		0	--	--	--	--
rs111835085^1,2	C	--	103994273(+)	`CAAGGG/ACCACA`	1	--	us2k¹		1		CSA	2
rs141842684^1,2		--	103994358(+)	`AGCTCA/GCTCTG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TRMT61A (103995509 - 104003410 bp)

Structural Variations
Database of Genomic Variants (DGV) 7 variations for TRMT61A: About this table

Variant ID	Type	Subtype	PubMed ID
dgv1992n71	CNV	Loss	21882294
nsv832883	CNV	Loss	17160897
dgv1993n71	CNV	Loss	21882294
nsv827068	CNV	Loss	20364138
nsv902300	CNV	Loss	21882294
dgv1994n71	CNV	Loss	21882294
nsv9170	CNV	Gain	18304495

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing TRMT61A

DNA2.0 Custom Variant and Variant Library Synthesis for TRMT61A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for TRMT61A: About MalaCards

malaria

TRMT61A for disorders About GeneDecksing

Export disorders for TRMT61A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TRMT61A gene, integrated from 10 sources (see all 16):
(articles sorted by number of sources associating them with TRMT61A)

Utopia: connect your pdf to the dynamic
world of online information

The bipartite structure of the tRNA m1A58 methyltransferase from S. cerevisiae is conserved in humans. (PubMed id 16043508)^{1, 2, 3} Ozanick S.... Anderson J.T. (RNA 2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)¹ Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (Cell 2012)
Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)² Bienvenut W.V....Giglione C. (amp 2012)
A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (Nat. Methods 2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (amp 2011)
Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)¹ Emanuele M.J....Elledge S.J. (Cell 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 115708	HGNC: 23790	AceView: FLJ40452	Ensembl:ENSG00000166166	euGenes: HUgn115708
ECgene: TRMT61A	H-InvDB: TRMT61A

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TRMT61A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TRMT61A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TRMT61A gene:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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TRMT61A Gene

TRNA Methyltransferase 61 Homolog A (S. Cerevisiae)

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TRMT61A Gene

TRNA Methyltransferase 61 Homolog A (S. Cerevisiae)

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