Aliases for TRMT61A Gene
Aliases for TRMT61A Gene
- TRNA Methyltransferase 61A 2 3 5
- TRNA(M1A58)-Methyltransferase Subunit TRMT61A 3 4
- TRNA(M1A58)MTase Subunit TRMT61A 3 4
- C14orf172 3 4
- TRM61 3 4
- TRNA (Adenine(58)-N(1))-Methyltransferase Catalytic Subunit TRMT61A 3
- TRNA (Adenine-N(1)-)-Methyltransferase Catalytic Subunit TRMT61A 3
- TRNA (Adenine-N(1)-)-Methyltransferase Catalytic Subunit TRM61 3
- TRNA Methyltransferase 61 Homolog A (S. Cerevisiae) 2
- TRNA(M1A58)-Methyltransferase Subunit TRM61 3
External Ids for TRMT61A Gene
- HGNC: 23790
- Entrez Gene: 115708
- Ensembl: ENSG00000166166
- UniProtKB: Q96FX7
Previous HGNC Symbols for TRMT61A Gene
- C14orf172
Previous GeneCards Identifiers for TRMT61A Gene
- GC14P103067
- GC14P103995
- GC14P084173
Summaries for TRMT61A Gene
GeneCards Summary for TRMT61A Gene
TRMT61A (TRNA Methyltransferase 61A) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. GO annotations related to this gene include tRNA (adenine-N1-)-methyltransferase activity.
UniProtKB/Swiss-Prot for TRMT61A Gene
-
Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT61A Gene
Genomics for TRMT61A Gene
Regulatory Elements for TRMT61A Gene
Enhancers for TRMT61A Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around TRMT61A on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the TRMT61A gene promoter:
Regulatory Element Products
Genomic Location for TRMT61A Gene
- Chromosome:
- 14
- Start:
- 103,529,172 bp from pter
- End:
- 103,537,073 bp from pter
- Size:
- 7,902 bases
- Orientation:
- Plus strand
Genomic View for TRMT61A Gene
Genes around TRMT61A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q32.33 by Ensembl
- 14q32.33 by Entrez Gene
- 14q32 by HGNC
TRMT61A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TRMT61A Gene
Proteins for TRMT61A Gene
-
Protein details for TRMT61A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96FX7-TRM61_HUMAN
- Recommended name:
- tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A
- Protein Accession:
- Q96FX7
- A6NN78
- Q8N7Q9
Protein attributes for TRMT61A Gene
- Size:
- 289 amino acids
- Molecular mass:
- 31382 Da
- Quaternary structure:
-
- Heterotetramer; composed of two copies of TRMT6 and two copies of TRMT61A.
- SequenceCaution:
-
- Sequence=BAC05168.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
Protein Expression for TRMT61A Gene
Selected DME Specific Peptides for TRMT61A Gene
- Q96FX7:
-
- GHTGYLTFA
- PTPELWT
- LPHRTQI
Post-translational modifications for TRMT61A Gene
Other Protein References for TRMT61A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for TRMT61A
- Novus Biologicals Antibodies for TRMT61A
- Invitrogen Antibodies for TRMT61A
- antibodies-online Antibodies for TRMT61A: See all 12
- GeneTex TRMT61A antibody for TRMT61A
-
Santa Cruz Biotechnology (SCBT) Antibodies for TRMT61A
Protein Products
-
OriGene Purified Proteins for TRMT61A
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- antibodies-online Proteins for TRMT61A: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for TRMT61A
Domains & Families for TRMT61A Gene
Gene Families for TRMT61A Gene
Protein Domains for TRMT61A Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TRMT61A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96FX7UniProtKB/Swiss-Prot:
TRM61_HUMAN :- Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
- Family:
-
- Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
Function for TRMT61A Gene
Molecular function for TRMT61A Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- S-adenosyl-L-methionine + adenine(58) in tRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine(58) in tRNA.
- UniProtKB/Swiss-Prot Function:
- Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
Enzyme Numbers (IUBMB) for TRMT61A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008168 | methyltransferase activity | IEA | -- |
| GO:0016429 | contributes_to tRNA (adenine-N1-)-methyltransferase activity | IBA,IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
Phenotypes for TRMT61A Gene
- GenomeRNAi human phenotypes for TRMT61A:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability after Maraba virus infection
- Decreased influenza A/WSN/33 replication
- Decreased viability of wild-type and TP53 knockout cells
- Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers
- Decreased influenza A H1N1 (A/WSN/33) virus numbers
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TRMT61A
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TRMT61A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TRMT61A gene
- Search ViGene Biosciences for TRMT61A
CRISPR Products
-
OriGene CRISPR knockouts for TRMT61A
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRMT61A
- GenScript: Design CRISPR guide RNA sequences for TRMT61A
miRNA for TRMT61A Gene
- miRTarBase miRNAs that target TRMT61A
miRNA Products
- Search ViGene Biosciences for TRMT61A
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for TRMT61A
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ViGene Biosciences ready-to-package AAV shRNAs for TRMT61A gene
Clone Products
-
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- VectorBuilder custom plasmid, inducible vectors for TRMT61A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TRMT61A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for TRMT61A gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TRMT61A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TRMT61A gene
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRMT61A Gene
Localization for TRMT61A Gene
Subcellular locations from UniProtKB/Swiss-Prot for TRMT61A Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0031515 | tRNA (m1A) methyltransferase complex | IBA,IEA | -- |
Pathways & Interactions for TRMT61A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | tRNA processing |
.55
|
|
| 2 | Gene Expression |
.48
|
|
Pathways by source for TRMT61A Gene
3 Reactome pathways for TRMT61A Gene
Interacting Proteins for TRMT61A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006400 | tRNA modification | TAS | -- |
| GO:0008033 | tRNA processing | IEA | -- |
| GO:0030488 | tRNA methylation | IEA | -- |
| GO:0032259 | methylation | IEA | -- |
No data available for SIGNOR curated interactions for TRMT61A Gene
Transcripts for TRMT61A Gene
mRNA/cDNA for TRMT61A Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (142) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TRMT61A Gene
CRISPR Products
-
OriGene CRISPR knockouts for TRMT61A
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRMT61A
- GenScript: Design CRISPR guide RNA sequences for TRMT61A
miRNA Products
- Search ViGene Biosciences for TRMT61A
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for TRMT61A
- Browse OriGene Inhibitory RNA Products For TRMT61A
-
ViGene Biosciences ready-to-package AAV shRNAs for TRMT61A gene
Clone Products
-
OriGene ORF clones in human for TRMT61A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TRMT61A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TRMT61A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | - |
Expression for TRMT61A Gene
This gene is overexpressed in Lung (30.3) and Breast (8.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRMT61A Gene
NURSA nuclear receptor signaling pathways regulating expression of TRMT61A Gene:
TRMT61ASOURCE GeneReport for Unigene cluster for TRMT61A Gene:
Hs.525610Primer Products
-
OriGene qPCR primer pairs for TRMT61A
-
OriGene qPCR primer pairs and template standards for TRMT61A
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRMT61A Gene
Orthologs for TRMT61A Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TRMT61A 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | TRMT61A 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | TRMT61A 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Trmt61a 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Trmt61a 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | TRMT61A 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | TRMT61A 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TRMT61A 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | TRMT61A 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | trmt61a 34 |
|
||
| Str.17346 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC53312 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | trmt61a 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG14544 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003966 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | CELE_W02A11.1 34 |
|
||
| W02A11.1 35 |
|
OneToOne | |||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AFL214C 34 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E15225g 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | GCD14 34 35 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT5G14600 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os04g0326300 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne | |
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | cpd1 34 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.8067 34 |
|
- Species where no ortholog for TRMT61A was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for TRMT61A Gene
No data available for Paralogs for TRMT61A Gene
Variants for TRMT61A Gene
| SNP ID | Clin | Chr 14 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000264732 | -- | 103,533,529(+) | TAGCT(A/G)TGGGG | intron-variant | |
| rs1000833590 | -- | 103,529,706(+) | TCAGT(C/T)TTTTC | intron-variant | |
| rs1000946114 | -- | 103,529,392(+) | TTGCC(A/T)CTGCA | intron-variant | |
| rs1000963646 | -- | 103,529,376(+) | CCGGC(C/T)TGGCC | intron-variant | |
| rs1001257891 | -- | 103,537,129(+) | CCAGG(C/T)GGGAG | downstream-variant-500B |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3635599 | CNV | gain | 21293372 |
| nsv1044967 | CNV | gain | 25217958 |
| nsv1054574 | CNV | loss | 25217958 |
| nsv478428 | CNV | novel sequence insertion | 20440878 |
| nsv566020 | CNV | loss | 21841781 |
| nsv566021 | CNV | loss | 21841781 |
| nsv827068 | CNV | loss | 20364138 |
| nsv832883 | CNV | loss | 17160897 |
| nsv9170 | CNV | gain | 18304495 |
| nsv952259 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
26.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.55;
11.80% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for TRMT61A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TRMT61A
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRMT61A Gene
Disorders for TRMT61A Gene
Relevant External Links for TRMT61A
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- TRMT61A
No disorders were found for TRMT61A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRMT61A Gene
Publications for TRMT61A Gene
- The bipartite structure of the tRNA m1A58 methyltransferase from S. cerevisiae is conserved in humans. (PMID: 16043508) Ozanick S. … Anderson J.T. (RNA 2005) 2 3 4 64
- Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA(3)(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target. (PMID: 26470919) Finer-Moore J. … Stroud R.M. (J. Mol. Biol. 2015) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- TRM6/61 connects PKCI+ with translational control through tRNAi(Met) stabilization: impact on tumorigenesis. (PMID: 26234676) Macari F. … Joubert D. (Oncogene 2016) 3 64
Products for TRMT61A Gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for TRMT61A
- VectorBuilder custom plasmid, inducible vectors for TRMT61A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TRMT61A
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for TRMT61A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
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- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
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- (122) diseasecard
- (123) NIH Rare Diseases
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