Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRMT61A Gene

protein-coding   GIFtS: 48
GCID: GC14P103995

tRNA methyltransferase 61 homolog A (S. cerevisiae)

(Previous name: chromosome 14 open reading frame 172 )
(Previous symbol: C14orf172)
 Explore 3 diseases affiliated with
TRMT61A via our new
 Human Malady Compendium 
Biological research products
for TRMT61A
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
TRNA Methyltransferase 61 Homolog A (S. Cerevisiae)1 2     Chromosome 14 Open Reading Frame 1721
C14orf1721 2 3     TRNA (Adenine(58)-N(1))-Methyltransferase Catalytic Subunit TRMT61A2
GCD141 2     TRNA (Adenine-N(1)-)-Methyltransferase Catalytic Subunit TRM612
Gcd14p1 2     TRNA (Adenine-N(1)-)-Methyltransferase Catalytic Subunit TRMT61A2
HTRM611     TRNA(M1A58)-Methyltransferase Subunit TRM612
TRM612 3     TRNA(M1A58)MTase Subunit TRM612
TRNA(M1A58)-Methyltransferase Subunit TRMT61A2 3     EC 2.1.1.2203
TRNA(M1A58)MTase Subunit TRMT61A2 3     EC 2.1.1.368
FLJ404521     

External Ids:    HGNC: 237901   Entrez Gene: 1157082   Ensembl: ENSG000001661667   UniProtKB: Q96FX73   
ORGUL members:         
NONCODE:n338528    

Export aliases for TRMT61A gene to outside databases

Previous GC identifers: GC14P103067 GC14P084173


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TRM61_HUMAN, Q96FX7
Function: Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of
N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRMT61A gene promoter:
         Max1   USF1   AP-2alpha isoform 3   USF-1:USF-2   AP-2alpha isoform 2   SRY   USF-1   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRMT61A promoter sequence
   Search SABiosciences Chromatin IP Primers for TRMT61A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRMT61A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32   Ensembl cytogenetic band:  14q32.32   HGNC cytogenetic band: 14q32

TRMT61A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRMT61A gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P103995:  view genomic region     (about GC identifiers)

Start:
103,995,509 bp from pter      End:
104,003,410 bp from pter
Size:
7,902 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TRM61_HUMAN, Q96FX7 (See protein sequence)
Recommended Name: tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A  
Size: 289 amino acids; 31382 Da
Subunit: tRNA (adenine-N(1)-)-methyltransferase is a heterodimer of TRM6 and TRM61
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=BAC05168.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Secondary accessions: A6NN78 Q8N7Q9

Explore the universe of human proteins at neXtProt for TRMT61A: NX_Q96FX7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96FX7

  • 3 DME Specific Peptides for TRMT61A (Q96FX7)
     LPHRTQI  PTPELWT  GHTGYLTFA 

    TRMT61A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_689520.2  
    ENSEMBL proteins: 
     ENSP00000374399   ENSP00000299202  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: TRMT61A
    OriGene Custom Protein Services for TRMT61A 
    GenScript Custom Purified and Recombinant Proteins Services for TRMT61A
    Novus Biologicals TRMT61A Protein
    Novus Biologicals TRMT61A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TRMT61A

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0031515tRNA (m1A) methyltransferase complex IEA--


    TRMT61A for ontologies           About GeneDecksing



    TRMT61A Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TRMT61A 
    GenScript Custom Superior Antibodies Services for TRMT61A
    Novus Biologicals TRMT61A Antibodies
    Search for Antibodies for TRMT61A at Abcam  
    Uscn Antibodies for TRMT61A
    Search ThermoFisher Antibodies for TRMT61A

    Assay Products for TRMT61A: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRMT61A
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TRMT61A


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TRMT61A for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR025809 tRNA_MeTrfase_GCD14_euk
     IPR014816 tRNA_MeTrfase_GCD14

    Graphical View of Domain Structure for InterPro Entry Q96FX7

    ProtoNet protein and cluster: Q96FX7

    UniProtKB/Swiss-Prot: TRM61_HUMAN, Q96FX7
    Similarity: Belongs to the methyltransferase superfamily. TRM61 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TRM61_HUMAN, Q96FX7
    Function: Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of
    N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA
    Catalytic activity: S-adenosyl-L-methionine + adenine(58) in tRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine(58)
    in tRNA

    Enzyme Numbers (IUBMB): EC 2.1.1.362 EC 2.1.1.2201

    miRNA
    Products:
        
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRMT61A
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate TRMT61A:
    hsa-miR-1184 hsa-miR-4254 hsa-miR-544 hsa-miR-196a* hsa-miR-2355-3p hsa-miR-591 hsa-miR-608
    SwitchGear 3'UTR luciferase reporter plasmidTRMT61A 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRMT61A (see all 4)
    OriGene shRNA RFP: TRMT61A
    OriGene siRNA: TRMT61A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRMT61A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRMT61A

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT61A (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT61A (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TRMT61A (NM_152307)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRMT61A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRMT61A 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TRMT61A
    Search LifeMap BioReagents cell lines for TRMT61A

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT61A

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016429tRNA (adenine-N1-)-methyltransferase activity IEA--


    TRMT61A for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for TRMT61A:
     Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Decreased viability of wild-ty 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRMT61A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/47 Interacting proteins for TRMT61A (Q96FX73 ENSP000003743994) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DBR1Q9UK593, ENSP000002608034I2D: score=1 STRING: ENSP00000260803
    EIF2AK4Q9P2K83, ENSP000002637914I2D: score=1 STRING: ENSP00000263791
    FARS2O953633, ENSP000002746804I2D: score=1 STRING: ENSP00000274680
    MRTO4Q9UKD23, ENSP000003643204I2D: score=1 STRING: ENSP00000364320
    MTIF2P461993, ENSP000002636294I2D: score=1 STRING: ENSP00000263629
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRMT61A

    2 HMDB Compounds for TRMT61A    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--
    Search CenterWatch for drugs/clinical trials and news about TRMT61A / TRM61 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRMT61A gene: 
    NM_152307.2  

    Unigene Cluster for TRMT61A:

    TRNA methyltransferase 61 homolog A (S. cerevisiae)
    Hs.525610  [show with all ESTs]
    Unigene Representative Sequence: NM_152307
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000389749(uc001yng.3 uc010aws.3) ENST00000299202

    miRNA
    Products:
         
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRMT61A
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate TRMT61A:
    hsa-miR-1184 hsa-miR-4254 hsa-miR-544 hsa-miR-196a* hsa-miR-2355-3p hsa-miR-591 hsa-miR-608
    SwitchGear 3'UTR luciferase reporter plasmidTRMT61A 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRMT61A (see all 4)
    OriGene shRNA RFP: TRMT61A
    OriGene siRNA: TRMT61A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRMT61A
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT61A (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT61A (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TRMT61A (NM_152307)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRMT61A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRMT61A 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRMT61A
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRMT61A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRMT61A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRMT61A

    Additional cDNA sequence: 

    BC007241.1 BC010167.2 BC016033.2 

    9 DOTS entries:

    DT.306574  DT.97840423  DT.100762946  DT.100772513  DT.100796595  DT.100833855  DT.75141547  DT.91761682 
    DT.120788522 

    24/142 AceView cDNA sequences (see all 142):

    CR599923 BM669685 CR625555 AW196578 BE276214 BQ648018 BQ950130 CR597205 
    AI885413 BE048174 BC010167 BM698902 CR605570 AA319355 CR620786 AI168476 
    CR616463 CR624022 AA338075 AI668655 AI573079 BX350653 BM926457 BM805254 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for TRMT61A    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
    SP1:                                    
    SP2:              -                     


    ECgene alternative splicing isoforms for TRMT61A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRMT61A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGGAGGCCG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See TRMT61A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRMT61A

    SOURCE GeneReport for Unigene cluster: Hs.525610
        SABiosciences Custom PCR Arrays for TRMT61A
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRMT61A
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRMT61A
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRMT61A
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRMT61A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT61A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TRMT61A gene from 10/36 species (see all 36)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trmt61a1 , 5 tRNA methyltransferase 61 homolog A (S. cerevisiae)5
    tRNA methyltransferase 61A1
    85.93(n)1
    91.35(a)1
      12 (61.09 cM)5
    3281621  NM_001099792.11  NP_001093262.11 
     1116781055 
    chicken
    (Gallus gallus)
    Aves TRMT61A1 tRNA methyltransferase 61 homolog A (S. cerevisiae) 66.67(n)
    70.76(a)
      423481  XM_421386.3  XP_421386.3 
    lizard
    (Anolis carolinensis)
    Reptilia TRMT61A6
    TRMT61B6
    --
    71(a)
    18(a)
    1 ↔ 1
    possible ortholog
    GL343232.1(36658-90468)
    1(248303365-248308737)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC533122 hypothetical protein MGC53312 73.18(n)    BC042219.1 
    zebrafish
    (Danio rerio)
    Actinopterygii trmt61a1 tRNA methyltransferase 61 homolog A (S. cerevisiae) 65.73(n)
    70.63(a)
      436593  NM_001002321.1  NP_001002321.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG145441 CG14544 55.36(n)
    51.05(a)
      43170  NM_143204.3  NP_651461.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_W02A11.11 Protein W02A11.1 52.04(n)
    47.48(a)
      173142  NM_060828.3  NP_493229.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GCD141 Gcd14p 47.23(n)
    45.11(a)
      853317   NP_012410.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G146001 tRNA (adenine-N1-)-methyltransferase 49.82(n)
    48.74(a)
      831312  NM_121464.1  NP_568302.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g03263001 hypothetical protein 55.02(n)
    49.63(a)
      4335490  NM_001059009.2  NP_001052474.2 


    ENSEMBL Gene Tree for TRMT61A (if available)
    TreeFam Gene Tree for TRMT61A (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/163 NCBI SNPs in TRMT61A are shown (see all 163    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1830099301,2
    --103993577(+) TCAATA/GAGATG 1 -- us2k10--------
    rs1446102281,2
    C,--103993826(+) GGAAA-/CCCACC 1 -- us2k10--------
    rs1421177781,2
    --103993864(+) CCTTAA/TAGGCA 1 -- us2k10--------
    rs563248431,2
    C,F,--103993875(+) CCCGGC/ACCTGA 1 -- us2k13Minor allele frequency- A:0.22WA 122
    rs1851538971,2
    --103993898(+) CACAGC/TTGAGA 1 -- us2k10--------
    rs1457113711,2
    --103993938(+) GAAAGC/TCAGAA 1 -- us2k10--------
    rs1481033051,2
    --103994074(+) GAGGCC/TGTAAG 1 -- us2k10--------
    rs1434402871,2
    --103994110(+) GTGGT-/GGGCCC 1 -- us2k10--------
    rs1418426841,2
    --103994358(+) AGCTCA/GCTCTG 1 -- us2k10--------
    rs1902618891,2
    --103994404(+) TGGCTC/GAGTGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TRMT61A (103995509 - 104003410 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for TRMT61A
         1 CNV: 30663

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRMT61A
    DNA2.0 Custom Variant and Variant Library Synthesis for TRMT61A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TRMT61A for disorders           About GeneDecksing

    3 diseases for TRMT61A:    About MalaCards
    homocysteine    tuberculosis    malaria


    Export disorders for TRMT61A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRMT61A gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with TRMT61A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The bipartite structure of the tRNA m1A58 methyltransferase from S. cerevisiae is conserved in humans. (PubMed id 16043508)1, 2, 3 Ozanick S.... Anderson J.T. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    10. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 115708 HGNC: 23790 AceView: FLJ40452 Ensembl:ENSG00000166166 euGenes: HUgn115708
    ECgene: TRMT61A H-InvDB: TRMT61A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRMT61A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRMT61A gene:
    Search GeneIP for patents involving TRMT61A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for TRMT61A  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRMT61A   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRMT61A  
     OriGene Protein Over-expression Lysate for TRMT61A   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for TRMT61A   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT61A   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT61A  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TRMT61A   OriGene Custom Protein Services for TRMT61A  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRMT61A
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRMT61A
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRMT61A
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRMT61A
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRMT61A
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRMT61A
     GenScript Custom Purified and Recombinant Proteins Services for TRMT61A GenScript cDNA clones with any tag delivered in your preferred vector for TRMT61A
     GenScript Custom Assay Services for TRMT61A GenScript Custom Superior Antibodies Services for TRMT61A
     GenScript Custom overexpressing Cell Line Services for TRMT61A CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TRMT61A promoter
     Search Chromatin IP Primers for TRMT61A
     RT2 qPCR Primer Assay in human, mouse, rat TRMT61A
     Search GNC Networks for TRMT61A
     SABiosciences Custom PCR Arrays for TRMT61A
     Search Tocris compounds for TRMT61A
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TRMT61A antibodies
     TRMT61A proteins
     TRMT61A lysates
     Search for Antibodies for TRMT61A at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for TRMT61A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     TRMT61A Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for TRMT61A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT61A
     SwitchGear 3'UTR luciferase reporter plasmids for TRMT61A
     SwitchGear Promoter luciferase reporter plasmids for TRMT61A
     Search ThermoFisher Antibodies for TRMT61A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRMT61A
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TRMT61A gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4