Aliases for TRMT61A Gene
Aliases for TRMT61A Gene
- TRNA Methyltransferase 61A 2 3 5
- MRNA Methyladenosine-N(1)-Methyltransferase Catalytic Subunit TRMT61A 3 4
- TRNA(M1A58)-Methyltransferase Subunit TRMT61A 3 4
- TRNA(M1A58)MTase Subunit TRMT61A 3 4
- C14orf172 3 4
- TRM61 3 4
- TRNA (Adenine(58)-N(1))-Methyltransferase Catalytic Subunit TRMT61A 3
- TRNA (Adenine-N(1)-)-Methyltransferase Catalytic Subunit TRMT61A 3
- TRNA (Adenine-N(1)-)-Methyltransferase Catalytic Subunit TRM61 3
- TRNA Methyltransferase 61 Homolog A (S. Cerevisiae) 2
- TRNA(M1A58)-Methyltransferase Subunit TRM61 3
External Ids for TRMT61A Gene
- HGNC: 23790
- Entrez Gene: 115708
- Ensembl: ENSG00000166166
- UniProtKB: Q96FX7
Previous HGNC Symbols for TRMT61A Gene
- C14orf172
Previous GeneCards Identifiers for TRMT61A Gene
- GC14P103067
- GC14P103995
- GC14P084173
Summaries for TRMT61A Gene
GeneCards Summary for TRMT61A Gene
TRMT61A (TRNA Methyltransferase 61A) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. Gene Ontology (GO) annotations related to this gene include tRNA (adenine-N1-)-methyltransferase activity.
UniProtKB/Swiss-Prot for TRMT61A Gene
-
Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Catalytic subunit of mRNA N(1)-methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29107537, PubMed:29072297).
Additional gene information for TRMT61A Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT61A Gene
Genomics for TRMT61A Gene
GeneHancer (GH) Regulatory Elements for TRMT61A Gene
Promoters and enhancers for TRMT61A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TRMT61A on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the TRMT61A gene promoter:
Regulatory Element Products
Genomic Locations for TRMT61A Gene
Genomic Locations for TRMT61A Gene
- chr14:103,529,172-103,537,073
- (GRCh38/hg38)
- Size:
- 7,902 bases
- Orientation:
- Plus strand
- chr14:103,995,509-104,003,410
- (GRCh37/hg19)
Genomic View for TRMT61A Gene
Genes around TRMT61A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q32.33 by Ensembl
- 14q32.33 by Entrez Gene
- 14q32 by HGNC
TRMT61A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TRMT61A Gene
Proteins for TRMT61A Gene
-
Protein details for TRMT61A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96FX7-TRM61_HUMAN
- Recommended name:
- tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A
- Protein Accession:
- Q96FX7
- A6NN78
- Q8N7Q9
Protein attributes for TRMT61A Gene
- Size:
- 289 amino acids
- Molecular mass:
- 31382 Da
- Quaternary structure:
-
- Heterotetramer; composed of two copies of TRMT6 and two copies of TRMT61A.
- SequenceCaution:
-
- Sequence=BAC05168.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
Protein Expression for TRMT61A Gene
Selected DME Specific Peptides for TRMT61A Gene
- Q96FX7:
-
- GHTGYLTFA
- PTPELWT
- LPHRTQI
Post-translational modifications for TRMT61A Gene
No Post-translational modifications
Other Protein References for TRMT61A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
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Assay Products
Domains & Families for TRMT61A Gene
Gene Families for TRMT61A Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for TRMT61A Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TRMT61A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96FX7UniProtKB/Swiss-Prot:
TRM61_HUMAN :- Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
- Family:
-
- Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
Function for TRMT61A Gene
Molecular function for TRMT61A Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- S-adenosyl-L-methionine + adenine(58) in tRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine(58) in tRNA.
- UniProtKB/Swiss-Prot CatalyticActivity:
- S-adenosyl-L-methionine + adenine in mRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine in mRNA.
- UniProtKB/Swiss-Prot Function:
- Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Catalytic subunit of mRNA N(1)-methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29107537, PubMed:29072297).
Enzyme Numbers (IUBMB) for TRMT61A Gene
Phenotypes From GWAS Catalog for TRMT61A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008168 | methyltransferase activity | IEA | -- |
| GO:0016429 | contributes_to tRNA (adenine-N1-)-methyltransferase activity | IBA,IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0061953 | mRNA (adenine-N1-)-methyltransferase activity | IDA | 29072297 |
Phenotypes for TRMT61A Gene
- GenomeRNAi human phenotypes for TRMT61A:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability after Maraba virus infection
- Decreased influenza A/WSN/33 replication
- Decreased viability of wild-type and TP53 knockout cells
- Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers
- Decreased influenza A H1N1 (A/WSN/33) virus numbers
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-
-
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miRNA for TRMT61A Gene
- miRTarBase miRNAs that target TRMT61A
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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-
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No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRMT61A Gene
Localization for TRMT61A Gene
Subcellular locations from UniProtKB/Swiss-Prot for TRMT61A Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0031515 | tRNA (m1A) methyltransferase complex | IEA,IBA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for TRMT61A Gene
Pathways & Interactions for TRMT61A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | tRNA processing |
.55
|
|
| 2 | Gene Expression |
.48
|
|
Pathways by source for TRMT61A Gene
3 Reactome pathways for TRMT61A Gene
Interacting Proteins for TRMT61A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006400 | tRNA modification | TAS | -- |
| GO:0008033 | tRNA processing | IEA | -- |
| GO:0030488 | tRNA methylation | IEA | -- |
| GO:0032259 | methylation | IEA | -- |
| GO:0080009 | mRNA methylation | IDA | 29072297 |
No data available for SIGNOR curated interactions for TRMT61A Gene
Drugs & Compounds for TRMT61A Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| s-adenosylhomocysteine | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| s-adenosylmethionine |
|
29908-03-0 |
|
Transcripts for TRMT61A Gene
mRNA/cDNA for TRMT61A Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (142) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TRMT61A Gene
CRISPR Products
-
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Vectors and viruses for KO, Activation, Repression, and more
-
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TRMT61A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | - |
Expression for TRMT61A Gene
This gene is overexpressed in Lung (30.3) and Breast (8.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRMT61A Gene
NURSA nuclear receptor signaling pathways regulating expression of TRMT61A Gene:
TRMT61ASOURCE GeneReport for Unigene cluster for TRMT61A Gene:
Hs.525610Primer Products
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No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRMT61A Gene
Orthologs for TRMT61A Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TRMT61A 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | TRMT61A 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | TRMT61A 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Trmt61a 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Trmt61a 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | TRMT61A 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | TRMT61A 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TRMT61A 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | TRMT61A 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | trmt61a 33 |
|
||
| Str.17346 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC53312 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | trmt61a 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG14544 33 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003966 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | CELE_W02A11.1 33 |
|
||
| W02A11.1 34 |
|
OneToOne | |||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AFL214C 33 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E15225g 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | GCD14 33 34 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT5G14600 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os04g0326300 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne | |
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | cpd1 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.8067 33 |
|
- Species where no ortholog for TRMT61A was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for TRMT61A Gene
No data available for Paralogs for TRMT61A Gene
Variants for TRMT61A Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000264732 | -- | 103,533,529(+) | G/A | intron_variant | |
| rs1000833590 | -- | 103,529,706(+) | C/T | intron_variant | |
| rs1000946114 | -- | 103,529,392(+) | T/A | intron_variant | |
| rs1000963646 | -- | 103,529,376(+) | C/T | intron_variant | |
| rs1001257891 | -- | 103,537,129(+) | C/T | downstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3635599 | CNV | gain | 21293372 |
| nsv1044967 | CNV | gain | 25217958 |
| nsv1054574 | CNV | loss | 25217958 |
| nsv478428 | CNV | novel sequence insertion | 20440878 |
| nsv566020 | CNV | loss | 21841781 |
| nsv566021 | CNV | loss | 21841781 |
| nsv827068 | CNV | loss | 20364138 |
| nsv832883 | CNV | loss | 17160897 |
| nsv9170 | CNV | gain | 18304495 |
| nsv952259 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
26.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.55;
11.80% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TRMT61A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TRMT61A
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRMT61A Gene
Disorders for TRMT61A Gene
Additional Disease Information for TRMT61A
No disorders were found for TRMT61A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRMT61A Gene
Publications for TRMT61A Gene
- The bipartite structure of the tRNA m1A58 methyltransferase from S. cerevisiae is conserved in humans. (PMID: 16043508) Ozanick S … Anderson JT (RNA (New York, N.Y.) 2005) 2 3 4 58
- The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution. (PMID: 29072297) Safra M … Schwartz S (Nature 2017) 3 4 58
- Base-Resolution Mapping Reveals Distinct m1A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts. (PMID: 29107537) Li X … Yi C (Molecular cell 2017) 3 4 58
- Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA(3)(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target. (PMID: 26470919) Finer-Moore J … Stroud RM (Journal of molecular biology 2015) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 14 available TRMT61A Antibodies ranked by validation data
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- Overview of 109 available TRMT61A gene related products
- orf clones - Search results for 109 available TRMT61A gene related products
- Overview of 109 available TRMT61A gene related products
- genomics-online: gRNA clones - Search results for 109 available TRMT61A gene related products
- Overview of 109 available TRMT61A gene related products
- genomics-online: primer clones - Search results for 109 available TRMT61A gene related products
- Overview of 109 available TRMT61A gene related products
- genomics-online: shRNA clones - Search results for 109 available TRMT61A gene related products
- Overview of 109 available TRMT61A gene related products
Sources for TRMT61A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew