Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRMT61A Gene

Aliases for TRMT61A Gene

  • TRNA Methyltransferase 61A 2 3
  • TRNA(M1A58)-Methyltransferase Subunit TRMT61A 3 4
  • TRNA(M1A58)MTase Subunit TRMT61A 3 4
  • C14orf172 3 4
  • TRM61 3 4
  • TRNA (Adenine(58)-N(1))-Methyltransferase Catalytic Subunit TRMT61A 3
  • TRNA (Adenine-N(1)-)-Methyltransferase Catalytic Subunit TRMT61A 3
  • TRNA (Adenine-N(1)-)-Methyltransferase Catalytic Subunit TRM61 3
  • TRNA Methyltransferase 61 Homolog A (S. Cerevisiae) 2
  • TRNA(M1A58)-Methyltransferase Subunit TRM61 3
  • Chromosome 14 Open Reading Frame 172 2
  • TRNA Methyltransferase 61 Homolog A 3
  • TRNA(M1A58)MTase Subunit TRM61 3
  • EC 4
  • EC 63
  • Gcd14p 3
  • HTRM61 3
  • GCD14 3

External Ids for TRMT61A Gene

Previous HGNC Symbols for TRMT61A Gene

  • C14orf172

Previous GeneCards Identifiers for TRMT61A Gene

  • GC14P103067
  • GC14P103995
  • GC14P084173

Summaries for TRMT61A Gene

GeneCards Summary for TRMT61A Gene

TRMT61A (TRNA Methyltransferase 61A) is a Protein Coding gene. GO annotations related to this gene include tRNA (adenine-N1-)-methyltransferase activity.

UniProtKB/Swiss-Prot for TRMT61A Gene

  • Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT61A Gene

Genomics for TRMT61A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRMT61A Gene

103,529,172 bp from pter
103,537,073 bp from pter
7,902 bases
Plus strand

Genomic View for TRMT61A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRMT61A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT61A Gene

Proteins for TRMT61A Gene

  • Protein details for TRMT61A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A
    Protein Accession:
    Secondary Accessions:
    • A6NN78
    • Q8N7Q9

    Protein attributes for TRMT61A Gene

    289 amino acids
    Molecular mass:
    31382 Da
    Quaternary structure:
    • tRNA (adenine-N(1)-)-methyltransferase is a heterodimer of TRM6 and TRM61.
    • Sequence=BAC05168.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

neXtProt entry for TRMT61A Gene

Proteomics data for TRMT61A Gene at MOPED

Selected DME Specific Peptides for TRMT61A Gene

Post-translational modifications for TRMT61A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRMT61A Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for TRMT61A Gene

Protein Domains for TRMT61A Gene

Suggested Antigen Peptide Sequences for TRMT61A Gene

Graphical View of Domain Structure for InterPro Entry



  • Q96FX7
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
genes like me logo Genes that share domains with TRMT61A: view

No data available for Gene Families for TRMT61A Gene

Function for TRMT61A Gene

Molecular function for TRMT61A Gene

UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl-L-methionine + adenine(58) in tRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine(58) in tRNA.
UniProtKB/Swiss-Prot Function: Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

Enzyme Numbers (IUBMB) for TRMT61A Gene

Gene Ontology (GO) - Molecular Function for TRMT61A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016429 contributes_to tRNA (adenine-N1-)-methyltransferase activity IBA --
genes like me logo Genes that share ontologies with TRMT61A: view
genes like me logo Genes that share phenotypes with TRMT61A: view

Animal Model Products

CRISPR Products

miRNA for TRMT61A Gene

miRTarBase miRNAs that target TRMT61A

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TRMT61A Gene

Localization for TRMT61A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRMT61A Gene

Subcellular locations from

Jensen Localization Image for TRMT61A Gene COMPARTMENTS Subcellular localization image for TRMT61A gene
Compartment Confidence
nucleus 2
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TRMT61A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0031515 tRNA (m1A) methyltransferase complex IBA --
genes like me logo Genes that share ontologies with TRMT61A: view

Pathways for TRMT61A Gene

SuperPathways for TRMT61A Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRMT61A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030488 tRNA methylation IBA --
genes like me logo Genes that share ontologies with TRMT61A: view

No data available for Pathways by source for TRMT61A Gene

Compounds for TRMT61A Gene

(2) HMDB Compounds for TRMT61A Gene

Compound Synonyms Cas Number PubMed IDs
  • (S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
genes like me logo Genes that share compounds with TRMT61A: view

Transcripts for TRMT61A Gene

mRNA/cDNA for TRMT61A Gene

(142) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRMT61A Gene

TRNA methyltransferase 61 homolog A (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRMT61A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT61A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP2: -

Relevant External Links for TRMT61A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRMT61A Gene

mRNA expression in normal human tissues for TRMT61A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRMT61A Gene

SOURCE GeneReport for Unigene cluster for TRMT61A Gene Hs.525610

genes like me logo Genes that share expressions with TRMT61A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRMT61A Gene

Orthologs for TRMT61A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRMT61A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRMT61A 35
  • 99.08 (n)
  • 99.27 (a)
TRMT61A 36
  • 88 (a)
(Bos Taurus)
Mammalia TRMT61A 35
  • 90.76 (n)
  • 95.44 (a)
TRMT61A 36
  • 95 (a)
(Canis familiaris)
Mammalia TRMT61A 35
  • 89.04 (n)
  • 94.81 (a)
TRMT61A 36
  • 95 (a)
(Mus musculus)
Mammalia Trmt61a 35
  • 85.93 (n)
  • 91.35 (a)
Trmt61a 16
Trmt61a 36
  • 90 (a)
(Monodelphis domestica)
Mammalia TRMT61A 36
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia TRMT61A 36
  • 67 (a)
(Rattus norvegicus)
Mammalia Trmt61a 35
  • 86.85 (n)
  • 92.39 (a)
(Gallus gallus)
Aves TRMT61A 35
  • 67.83 (n)
  • 72.13 (a)
TRMT61A 36
  • 66 (a)
(Anolis carolinensis)
Reptilia TRMT61A 36
  • 67 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC53312 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17346 35
trmt61a 35
  • 65.16 (n)
  • 69.69 (a)
(Danio rerio)
Actinopterygii trmt61a 35
  • 65.73 (n)
  • 70.63 (a)
trmt61a 36
  • 63 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003966 35
  • 54.78 (n)
  • 52.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14544 35
  • 55.17 (n)
  • 50.87 (a)
CG14544 36
  • 45 (a)
(Caenorhabditis elegans)
Secernentea CELE_W02A11.1 35
  • 53.93 (n)
  • 50.21 (a)
W02A11.1 36
  • 42 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL214C 35
  • 52.71 (n)
  • 48.29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GCD14 35
  • 46.95 (n)
  • 44.68 (a)
GCD14 36
  • 31 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E15225g 35
  • 48.72 (n)
  • 44.44 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G14600 35
  • 49.82 (n)
  • 48.74 (a)
(Oryza sativa)
Liliopsida Os04g0326300 35
  • 55.02 (n)
  • 49.63 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cpd1 35
  • 45.69 (n)
  • 42.24 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8067 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
Species with no ortholog for TRMT61A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRMT61A Gene

Gene Tree for TRMT61A (if available)
Gene Tree for TRMT61A (if available)

Paralogs for TRMT61A Gene

No data available for Paralogs for TRMT61A Gene

Variants for TRMT61A Gene

Sequence variations from dbSNP and Humsavar for TRMT61A Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs13967 -- 103,535,752(-) CTTTA(A/G)GAGGT utr-variant-3-prime
rs754287 -- 103,531,188(+) TGAAC(A/T)AGAGA intron-variant
rs754288 -- 103,531,078(+) TGTGG(C/T)GGGTG intron-variant
rs911552 -- 103,533,171(-) AGAGG(C/T)TTTGG intron-variant
rs911553 -- 103,533,139(-) CAGAC(C/T)CCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRMT61A Gene

Variant ID Type Subtype PubMed ID
nsv832883 CNV Loss 17160897
dgv1992n71 CNV Loss 21882294
nsv902300 CNV Loss 21882294
dgv1993n71 CNV Loss 21882294
dgv1994n71 CNV Loss 21882294
nsv827068 CNV Loss 20364138
nsv9170 CNV Gain 18304495

Relevant External Links for TRMT61A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRMT61A Gene

Disorders for TRMT61A Gene

No disorders were found for TRMT61A Gene.

No data available for UniProtKB/Swiss-Prot for TRMT61A Gene

Publications for TRMT61A Gene

  1. The bipartite structure of the tRNA m1A58 methyltransferase from S. cerevisiae is conserved in humans. (PMID: 16043508) Ozanick S. … Anderson J.T. (RNA 2005) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. GCD14p, a repressor of GCN4 translation, cooperates with Gcd10p and Lhp1p in the maturation of initiator methionyl-tRNA in Saccharomyces cerevisiae. (PMID: 10330157) Calvo O. … Tamame M. (Mol. Cell. Biol. 1999) 23
  5. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3

Products for TRMT61A Gene

Sources for TRMT61A Gene

Back to Top