TRMT61A Gene

Aliases
for TRMT61A gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC14P103067 GC14P084173

Summaries
for TRMT61A gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for TRMT61A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000014.8  NC_018925.2  NT_026437.13  

SwitchGear Promoter luciferase reporter plasmid: TRMT61A promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRMT61A

TRMT61A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P103995:  view genomic region     (about GC identifiers)

Proteins
for TRMT61A gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for TRMT61A: NX_Q96FX7

Explore proteomics data for TRMT61A at MOPED

Post-translational modifications: 

TRMT61A Human Recombinant Protein Products:

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	antibodies-online peptides for TRMT61A

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	antibodies-online kits for TRMT61A (8 products)

Domains /
Families
for TRMT61A gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q96FX7

Find genes that share domains with TRMT61A           About GenesLikeMe

Function
for TRMT61A gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Enzyme Numbers (IUBMB): EC 2.1.1.36² EC 2.1.1.220¹

     Gene Ontology (GO): 1 molecular function term:    About this table

genOway: Develop your customized and physiologically relevant rodent model for TRMT61A

miRNA Products:		miRTarBase miRNAs that target TRMT61A: hsa-mir-92a-3p (MIRT049081), hsa-mir-342-3p (MIRT043665), hsa-mir-769-5p (MIRT039179)
		Block miRNA regulation of human, mouse, rat TRMT61A using miScript Target Protectors
		7 qRT-PCR Assays for microRNAs that regulate TRMT61A:
		hsa-miR-1184 hsa-miR-4254 hsa-miR-544 hsa-miR-196a* hsa-miR-2355-3p hsa-miR-591 hsa-miR-608
		SwitchGear 3'UTR luciferase reporter plasmid: TRMT61A 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TRMT61A
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Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for TRMT61A

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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRMT61A

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT61A

Localization
for TRMT61A gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	2
cytosol	1
extracellular	1
mitochondrion	1
peroxisome	1

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Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for TRMT61A gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 1 biological process term:    About this table

Drugs & Compounds
for TRMT61A gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for TRMT61A gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for TRMT61A gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TRMT61A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AAGGAGGCCG

About this image

Primer Products:		OriGene qPCR primer pairs and template standards for TRMT61A OriGene qSTAR qPCR primer pairs in human, mouse for TRMT61A
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRMT61A
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		QuantiFast Probe-based Assays in human, mouse, rat TRMT61A

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT61A

Orthologs
for TRMT61A gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for TRMT61A gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Genomic Variants
for TRMT61A gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TRMT61A (see all 226)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1830099301,2		--	103993577(+)	TCAATA/GAGATG	1	--	us2k1		0	--	--	--	--
rs1446102281,2	C	--	103993826(+)	GGAAA-/CCCACC	1	--	us2k1		0	--	--	--	--
rs1421177781,2		--	103993864(+)	CCTTAA/TAGGCA	1	--	us2k1		0	--	--	--	--
rs563248431,2	C,F	--	103993875(+)	CCCGGC/ACCTGA	1	--	us2k1		3		WA	122
rs1851538971,2		--	103993898(+)	CACAGC/TTGAGA	1	--	us2k1		0	--	--	--	--
rs1457113711,2		--	103993938(+)	GAAAGC/TCAGAA	1	--	us2k1		0	--	--	--	--
rs1481033051,2		--	103994074(+)	GAGGCC/TGTAAG	1	--	us2k1		0	--	--	--	--
rs1434402871,2		--	103994112(+)	GTGGT-/GGGCCC	1	--	us2k1		0	--	--	--	--
rs1118350851,2	C	--	103994273(+)	CAAGGG/ACCACA	1	--	us2k1		1		CSA	2
rs1418426841,2		--	103994358(+)	AGCTCA/GCTCTG	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for TRMT61A (103995509 - 104003410 bp)

Structural Variations
     Database of Genomic Variants (DGV) 7 variations for TRMT61A:    About this table    

Variant ID	Type	Subtype	PubMed ID
dgv1992n71	CNV	Loss	21882294
nsv832883	CNV	Loss	17160897
dgv1993n71	CNV	Loss	21882294
nsv827068	CNV	Loss	20364138
nsv902300	CNV	Loss	21882294
dgv1994n71	CNV	Loss	21882294
nsv9170	CNV	Gain	18304495

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing TRMT61A

DNA2.0 Custom Variant and Variant Library Synthesis for TRMT61A

Disorders / Diseases
for TRMT61A gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for TRMT61A gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. The bipartite structure of the tRNA m1A58 methyltransferase from S. cerevisiae is conserved in humans. (PubMed id 16043508)^{1, 2, 3} Ozanick S.... Anderson J.T. (RNA 2005)
2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
4. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)¹ Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
5. A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (Cell 2012)
6. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)² Bienvenut W.V....Giglione C. (amp 2012)
7. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (Nat. Methods 2012)
8. Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (amp 2011)
10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)¹ Emanuele M.J....Elledge S.J. (Cell 2011)

External Searches for TRMT61A gene

Genome Databases showing TRMT61A gene

Other Databases showing TRMT61A gene

Specialized Databases showing TRMT61A gene

Products
for TRMT61A gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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