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Aliases for TRMT61A Gene

Aliases for TRMT61A Gene

  • TRNA Methyltransferase 61A 2 3 5
  • TRNA(M1A58)-Methyltransferase Subunit TRMT61A 3 4
  • TRNA(M1A58)MTase Subunit TRMT61A 3 4
  • C14orf172 3 4
  • TRM61 3 4
  • TRNA (Adenine(58)-N(1))-Methyltransferase Catalytic Subunit TRMT61A 3
  • TRNA (Adenine-N(1)-)-Methyltransferase Catalytic Subunit TRMT61A 3
  • TRNA (Adenine-N(1)-)-Methyltransferase Catalytic Subunit TRM61 3
  • TRNA Methyltransferase 61 Homolog A (S. Cerevisiae) 2
  • TRNA(M1A58)-Methyltransferase Subunit TRM61 3
  • Chromosome 14 Open Reading Frame 172 2
  • TRNA Methyltransferase 61 Homolog A 3
  • TRNA(M1A58)MTase Subunit TRM61 3
  • EC 2.1.1.220 4
  • EC 2.1.1.36 61
  • Gcd14p 3
  • HTRM61 3
  • GCD14 3

External Ids for TRMT61A Gene

Previous HGNC Symbols for TRMT61A Gene

  • C14orf172

Previous GeneCards Identifiers for TRMT61A Gene

  • GC14P103067
  • GC14P103995
  • GC14P084173

Summaries for TRMT61A Gene

GeneCards Summary for TRMT61A Gene

TRMT61A (TRNA Methyltransferase 61A) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. GO annotations related to this gene include tRNA (adenine-N1-)-methyltransferase activity.

UniProtKB/Swiss-Prot for TRMT61A Gene

  • Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT61A Gene

Genomics for TRMT61A Gene

Regulatory Elements for TRMT61A Gene

Enhancers for TRMT61A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G104391 1.4 FANTOM5 Ensembl ENCODE 11.5 +863.9 863867 3.5 KLF1 SUZ12 SALL2 YBX1 PLRG1 BCL11B ZBTB7B CTBP1 ZFHX2 ZNF366 XRCC3 ZFYVE21 TRMT61A PACS2 LINC00638 CKB RNU6-684P GC14M104401 ENSG00000258598
GH14G103508 0.7 dbSUPER 17.5 -20.2 -20166 1.1 BCOR SOX13 GATAD2A SP5 NR2F1 CEBPB CEBPG ZNF121 CEBPA NR2F6 MARK3 TRMT61A RNU7-160P GC14M103376 GC14P103445
GH14G103679 1 ENCODE dbSUPER 10.4 +150.4 150417 0.2 CTCF USF1 ARID4B SIN3A MAX ZNF2 RAD21 POLR2A ZNF143 SMC3 XRCC3 ZFYVE21 RNU7-160P TRMT61A CKB PPP1R13B ENSG00000246451 PIR59138
GH14G103505 0.7 ENCODE dbSUPER 12.7 -23.8 -23834 0.2 CTCF ZNF394 TRMT61A RNU7-160P MARK3 GC14M103376 GC14P103445
GH14G103655 0.7 ENCODE 10.9 +127.8 127808 2.7 ZNF362 ZNF280D ZNF491 ZNF507 ZNF664 ZNF366 ZNF512 ZNF580 RCOR1 MAFK ZFYVE21 ENSG00000246451 XRCC3 TRMT61A CKB ENSG00000202275 PIR59138 LOC105370688
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRMT61A on UCSC Golden Path with GeneCards custom track

Promoters for TRMT61A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000073573 28 1201 FOXA2 ATF1 AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 GLIS2

Genomic Location for TRMT61A Gene

Chromosome:
14
Start:
103,529,172 bp from pter
End:
103,537,073 bp from pter
Size:
7,902 bases
Orientation:
Plus strand

Genomic View for TRMT61A Gene

Genes around TRMT61A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRMT61A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRMT61A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT61A Gene

Proteins for TRMT61A Gene

  • Protein details for TRMT61A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FX7-TRM61_HUMAN
    Recommended name:
    tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A
    Protein Accession:
    Q96FX7
    Secondary Accessions:
    • A6NN78
    • Q8N7Q9

    Protein attributes for TRMT61A Gene

    Size:
    289 amino acids
    Molecular mass:
    31382 Da
    Quaternary structure:
    • Heterotetramer; composed of two copies of TRMT6 and two copies of TRMT61A.
    SequenceCaution:
    • Sequence=BAC05168.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRMT61A Gene

neXtProt entry for TRMT61A Gene

Selected DME Specific Peptides for TRMT61A Gene

Q96FX7:
  • GHTGYLTFA
  • PTPELWT
  • LPHRTQI

Post-translational modifications for TRMT61A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRMT61A Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for TRMT61A Gene

Protein Domains for TRMT61A Gene

Suggested Antigen Peptide Sequences for TRMT61A Gene

Graphical View of Domain Structure for InterPro Entry

Q96FX7

UniProtKB/Swiss-Prot:

TRM61_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
genes like me logo Genes that share domains with TRMT61A: view

Function for TRMT61A Gene

Molecular function for TRMT61A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + adenine(58) in tRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine(58) in tRNA.
UniProtKB/Swiss-Prot Function:
Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

Enzyme Numbers (IUBMB) for TRMT61A Gene

Gene Ontology (GO) - Molecular Function for TRMT61A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0016429 contributes_to tRNA (adenine-N1-)-methyltransferase activity IBA,IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with TRMT61A: view
genes like me logo Genes that share phenotypes with TRMT61A: view

Animal Model Products

CRISPR Products

miRNA for TRMT61A Gene

miRTarBase miRNAs that target TRMT61A

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRMT61A Gene

Localization for TRMT61A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRMT61A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRMT61A gene
Compartment Confidence
nucleus 5
extracellular 1
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TRMT61A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
GO:0031515 tRNA (m1A) methyltransferase complex IBA,IEA --
genes like me logo Genes that share ontologies with TRMT61A: view

Pathways & Interactions for TRMT61A Gene

genes like me logo Genes that share pathways with TRMT61A: view

Pathways by source for TRMT61A Gene

Gene Ontology (GO) - Biological Process for TRMT61A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006400 tRNA modification TAS --
GO:0008033 tRNA processing IEA --
GO:0030488 tRNA methylation IEA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with TRMT61A: view

No data available for SIGNOR curated interactions for TRMT61A Gene

Drugs & Compounds for TRMT61A Gene

(2) Drugs for TRMT61A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0
genes like me logo Genes that share compounds with TRMT61A: view

Transcripts for TRMT61A Gene

mRNA/cDNA for TRMT61A Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(142) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRMT61A Gene

TRNA methyltransferase 61 homolog A (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT61A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for TRMT61A Gene

GeneLoc Exon Structure for
TRMT61A
ECgene alternative splicing isoforms for
TRMT61A

Expression for TRMT61A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRMT61A Gene

Protein differential expression in normal tissues from HIPED for TRMT61A Gene

This gene is overexpressed in Lung (30.3) and Breast (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRMT61A Gene



Protein tissue co-expression partners for TRMT61A Gene

NURSA nuclear receptor signaling pathways regulating expression of TRMT61A Gene:

TRMT61A

SOURCE GeneReport for Unigene cluster for TRMT61A Gene:

Hs.525610
genes like me logo Genes that share expression patterns with TRMT61A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRMT61A Gene

Orthologs for TRMT61A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRMT61A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRMT61A 34 35
  • 99.08 (n)
cow
(Bos Taurus)
Mammalia TRMT61A 34 35
  • 90.76 (n)
dog
(Canis familiaris)
Mammalia TRMT61A 34 35
  • 89.04 (n)
rat
(Rattus norvegicus)
Mammalia Trmt61a 34
  • 86.85 (n)
mouse
(Mus musculus)
Mammalia Trmt61a 34 16 35
  • 85.93 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TRMT61A 35
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRMT61A 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRMT61A 34 35
  • 67.83 (n)
lizard
(Anolis carolinensis)
Reptilia TRMT61A 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trmt61a 34
  • 65.16 (n)
Str.17346 34
African clawed frog
(Xenopus laevis)
Amphibia MGC53312 34
zebrafish
(Danio rerio)
Actinopterygii trmt61a 34 35
  • 65.73 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14544 34 35
  • 55.17 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003966 34
  • 54.78 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_W02A11.1 34
  • 53.93 (n)
W02A11.1 35
  • 42 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL214C 34
  • 52.71 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E15225g 34
  • 48.72 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GCD14 34 35
  • 46.95 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G14600 34
  • 49.82 (n)
rice
(Oryza sativa)
Liliopsida Os04g0326300 34
  • 55.02 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 51 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cpd1 34
  • 45.69 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8067 34
Species where no ortholog for TRMT61A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRMT61A Gene

ENSEMBL:
Gene Tree for TRMT61A (if available)
TreeFam:
Gene Tree for TRMT61A (if available)

Paralogs for TRMT61A Gene

No data available for Paralogs for TRMT61A Gene

Variants for TRMT61A Gene

Sequence variations from dbSNP and Humsavar for TRMT61A Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000264732 -- 103,533,529(+) TAGCT(A/G)TGGGG intron-variant
rs1000833590 -- 103,529,706(+) TCAGT(C/T)TTTTC intron-variant
rs1000946114 -- 103,529,392(+) TTGCC(A/T)CTGCA intron-variant
rs1000963646 -- 103,529,376(+) CCGGC(C/T)TGGCC intron-variant
rs1001257891 -- 103,537,129(+) CCAGG(C/T)GGGAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TRMT61A Gene

Variant ID Type Subtype PubMed ID
esv3635599 CNV gain 21293372
nsv1044967 CNV gain 25217958
nsv1054574 CNV loss 25217958
nsv478428 CNV novel sequence insertion 20440878
nsv566020 CNV loss 21841781
nsv566021 CNV loss 21841781
nsv827068 CNV loss 20364138
nsv832883 CNV loss 17160897
nsv9170 CNV gain 18304495
nsv952259 CNV deletion 24416366

Variation tolerance for TRMT61A Gene

Residual Variation Intolerance Score: 26.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRMT61A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRMT61A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRMT61A Gene

Disorders for TRMT61A Gene

Relevant External Links for TRMT61A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRMT61A

No disorders were found for TRMT61A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRMT61A Gene

Publications for TRMT61A Gene

  1. The bipartite structure of the tRNA m1A58 methyltransferase from S. cerevisiae is conserved in humans. (PMID: 16043508) Ozanick S. … Anderson J.T. (RNA 2005) 2 3 4 64
  2. Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA(3)(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target. (PMID: 26470919) Finer-Moore J. … Stroud R.M. (J. Mol. Biol. 2015) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. TRM6/61 connects PKCI+ with translational control through tRNAi(Met) stabilization: impact on tumorigenesis. (PMID: 26234676) Macari F. … Joubert D. (Oncogene 2016) 3 64

Products for TRMT61A Gene

Sources for TRMT61A Gene

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