TRMT6 Gene
protein-coding GIFtS: 46
GCID: GC20M005917
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|
tRNA methyltransferase 6 homolog (S. cerevisiae)
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Aliases
for TRMT6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TRNA Methyltransferase 6 Homolog (S. Cerevisiae)1 2 | | MGC50291 | | GCD101 2 | | TRNA (Adenine(58)-N(1))-Methyltransferase Non-Catalytic Subunit TRM62 | | Gcd10p1 2 | | TRNA (Adenine-N(1)-)-Methyltransferase Non-Catalytic Subunit TRM62 | | TRNA(M1A58)-Methyltransferase Subunit TRM62 3 | | KIAA11533 | | TRNA(M1A58)MTase Subunit TRM62 3 | | TRM63 | | CGI-091 | | |
Export aliases for TRMT6 gene to outside databasesPrevious GC identifers: GC20M005867 GC20M005875 |
Summaries
for TRMT6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TRMT6:
The protein encoded by this gene is similar to an uncharacterized protein from C. elegans. Although the function of theencoded protein is unknown, it shares weak sequence similarity to a region of S. cerevisiae translation initiationfactor subunit Gcd10p. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TRM6_HUMAN, Q9UJA5Function: Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation ofN(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA
|
Genomic Views
for TRMT6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011387.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TRMT6 gene promoter:
RFX1 STAT1 HOXA3 AML1a p53 POU3F1 STAT1beta POU3F2 STAT1alpha c-Myb
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRMT6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRMT6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20p12.3 Ensembl cytogenetic band: 20p12.3 HGNC cytogenetic band: 20p12.3TRMT6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M005917: view genomic region
(about GC identifiers)
Start:
|
5,917,881 bp from pter |
End:
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5,931,182 bp from pter |
Size:
|
13,302 bases |
Orientation:
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minus strand |
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Proteins
for TRMT6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TRM6_HUMAN, Q9UJA5 (See
protein sequence)Recommended Name: tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 Size: 497 amino acids; 55799 Da
Subunit: tRNA (adenine-N(1)-)-methyltransferase is a heterodimer of TRM6 and TRM61
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=BAA86467.1; Type=Erroneous initiation; Sequence=BAA86467.1; Type=Frameshift; Positions=319;
Secondary accessions: Q76P92 Q9BQV5 Q9ULR7 Q9Y2Z8Alternative splicing: 3 isoforms: Q9UJA5-1 Q9UJA5-2 Q9UJA5-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TRMT6: NX_Q9UJA5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UJA5
TRMT6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057023.2
ENSEMBL proteins: ENSP00000203001 ENSP00000392070
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
TRMT6 for ontologies About GeneDecksing
TRMT6 Antibody Products:
Assay Products for TRMT6: |
Protein
Domains /
Families
for TRMT6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRMT6 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UJA5ProtoNet protein and cluster: Q9UJA5 UniProtKB/Swiss-Prot: TRM6_HUMAN, Q9UJA5Similarity: Belongs to the TRM6/GCD10 family |
Function
for TRMT6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TRM6_HUMAN, Q9UJA5Function: Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation ofN(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for TRMT6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRMT6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT6 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003743 | translation initiation factor activity |
IEA | -- | | GO:0008168 | methyltransferase activity |
-- | -- |
TRMT6 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for TRMT6:
|
Pathways & Interactions
for TRMT6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRMT6
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/10 Interacting proteins for TRMT6 (Q9UJA53 ENSP000002030014) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006446 | regulation of translational initiation |
IEA | -- | | GO:0008033 | tRNA processing |
IEA | -- |
TRMT6 for ontologies About GeneDecksing
|
Drugs & Compounds
for TRMT6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TRMT6
Search CenterWatch for drugs/clinical trials and news about TRMT6 / TRM6
|
Transcripts
for TRMT6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TRMT6 gene: NM_015939.3 Unigene Cluster for TRMT6: TRNA methyltransferase 6 homolog (S. cerevisiae) Hs.128791 [show with all ESTs]Unigene Representative Sequence: AB0329795 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000473131(uc010gbo.1) ENST00000203001(uc002wmh.1 uc010zra.1)
ENST00000466974(uc010gbn.1) ENST00000493972 ENST00000453074
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TRMT6 (NM_015939) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRMT6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRMT6 |
Additional cDNA sequence: AB032979.1 AF132943.1 AK000613.1 AK300812.1 AK308648.1 AK309205.1 BC001262.1 8 DOTS entries: DT.455296 DT.100758272 DT.100758279 DT.91724096 DT.95371445 DT.100758275 DT.100758276 DT.92425610 24/119 AceView cDNA sequences (see all 119): BF195794 BQ009182 CA312079 AI917089 BP364288 BM998619 AI357153 BQ943164 AW674581 BQ007100 AA405657 BM989199 BQ083075 CB131654 CR607627 CB241210 CA774794 AA812282 AB032979 CR601280 AW590755 BC001262 NM_015939 AI379353
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for TRMT6 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TRMT6
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Expression
for TRMT6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRMT6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAGAAATTT
About this image
See TRMT6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRMT6
SOURCE GeneReport for Unigene cluster: Hs.128791
UniProtKB/Swiss-Prot: TRM6_HUMAN, Q9UJA5Tissue specificity: Expressed in brain, liver, testis and ovary
SABiosciences Custom PCR Arrays for TRMT6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRMT6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TRMT6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRMT6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRMT6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT6 |
Orthologs
for TRMT6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TRMT6 gene from 9/31 species (see all 31) About this table
ENSEMBL Gene Tree for TRMT6 (if available)
TreeFam Gene Tree for TRMT6 (if available) |
Paralogs
for TRMT6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TRMT6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TRMT6 (5917881 - 5931182 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TRMT6
1 CNV: 59029 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRMT6 |
|
Disorders
/ Diseases
for TRMT6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TRMT6 for disorders About GeneDecksing
1  disease for TRMT6: About MalaCardsmalaria
Export disorders for TRMT6 gene to outside databases
|
Publications
for TRMT6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRMT6 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with TRMT6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The bipartite structure of the tRNA m1A58 methyltransferase from S. cerevisiae is conserved in humans. (PubMed id 16043508)1, 2, 3 Ozanick S.... Anderson J.T. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
- Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2 Hirosawa M.... Ohara O. (1999)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
|
External Searches for TRMT6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TRMT6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRMT6 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing TRMT6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TRMT6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TRMT6 gene:
Search GeneIP for patents involving TRMT6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TRMT6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TRMT6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRMT6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRMT6 | | | OriGene Protein Over-expression Lysate for TRMT6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TRMT6 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TRMT6 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRMT6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRMT6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRMT6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRMT6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRMT6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRMT6 |
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 | | | TRMT6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT6 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRMT6 |
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