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Aliases for TRMT6 Gene

Aliases for TRMT6 Gene

  • TRNA Methyltransferase 6 2 3 5
  • TRNA(M1A58)MTase Subunit TRM6 3 4
  • TRNA Methyltransferase 6 Homolog (S. Cerevisiae) 2
  • TRNA(M1A58)-Methyltransferase Subunit TRM6 4
  • TRNA Methyltransferase 6 Homolog 3
  • KIAA1153 4
  • CGI-09 3
  • Gcd10p 3
  • GCD10 3
  • TRM6 4

External Ids for TRMT6 Gene

Previous GeneCards Identifiers for TRMT6 Gene

  • GC20M005867
  • GC20M005875
  • GC20M005917

Summaries for TRMT6 Gene

Entrez Gene Summary for TRMT6 Gene

  • This gene encodes a member of the tRNA methyltransferase 6 protein family. A similar protein in yeast is part of a two component methyltransferase, which is involved in the posttranslational modification that produces the modified nucleoside 1-methyladenosine in tRNAs. Modified 1-methyladenosine influences initiator methionine stability and may be involved in the replication of human immunodeficiency virus type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for TRMT6 Gene

TRMT6 (TRNA Methyltransferase 6) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. GO annotations related to this gene include poly(A) RNA binding and translation initiation factor activity.

UniProtKB/Swiss-Prot for TRMT6 Gene

  • Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT6 Gene

Genomics for TRMT6 Gene

Regulatory Elements for TRMT6 Gene

Enhancers for TRMT6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRMT6 on UCSC Golden Path with GeneCards custom track

Promoters for TRMT6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRMT6 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRMT6 Gene

5,937,235 bp from pter
5,950,558 bp from pter
13,324 bases
Minus strand

Genomic View for TRMT6 Gene

Genes around TRMT6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRMT6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRMT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT6 Gene

Proteins for TRMT6 Gene

  • Protein details for TRMT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6
    Protein Accession:
    Secondary Accessions:
    • B4DUV6
    • Q76P92
    • Q9BQV5
    • Q9ULR7
    • Q9Y2Z8

    Protein attributes for TRMT6 Gene

    497 amino acids
    Molecular mass:
    55799 Da
    Quaternary structure:
    • tRNA (adenine-N(1)-)-methyltransferase is a heterodimer of TRM6 and TRM61.
    • Sequence=BAA86467.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA86467.1; Type=Frameshift; Positions=319; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRMT6 Gene

    Alternative splice isoforms for TRMT6 Gene


neXtProt entry for TRMT6 Gene

Proteomics data for TRMT6 Gene at MOPED

Post-translational modifications for TRMT6 Gene

  • Ubiquitination at Lys 112 and Lys 273
  • Modification sites at PhosphoSitePlus

Other Protein References for TRMT6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRMT6 Gene

Domains & Families for TRMT6 Gene

Protein Domains for TRMT6 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRM6/GCD10 family.
  • Belongs to the TRM6/GCD10 family.
genes like me logo Genes that share domains with TRMT6: view

No data available for Gene Families for TRMT6 Gene

Function for TRMT6 Gene

Molecular function for TRMT6 Gene

UniProtKB/Swiss-Prot Function:
Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
genes like me logo Genes that share phenotypes with TRMT6: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRMT6 Gene

Localization for TRMT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRMT6 Gene

Subcellular locations from

Jensen Localization Image for TRMT6 Gene COMPARTMENTS Subcellular localization image for TRMT6 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TRMT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with TRMT6: view

Pathways & Interactions for TRMT6 Gene

genes like me logo Genes that share pathways with TRMT6: view

Pathways by source for TRMT6 Gene

Gene Ontology (GO) - Biological Process for TRMT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006400 tRNA modification TAS --
GO:0030488 tRNA methylation IEA --
genes like me logo Genes that share ontologies with TRMT6: view

No data available for SIGNOR curated interactions for TRMT6 Gene

Drugs & Compounds for TRMT6 Gene

No Compound Related Data Available

Transcripts for TRMT6 Gene

Unigene Clusters for TRMT6 Gene

TRNA methyltransferase 6 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP3: - -

Relevant External Links for TRMT6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRMT6 Gene

mRNA expression in normal human tissues for TRMT6 Gene

Protein differential expression in normal tissues from HIPED for TRMT6 Gene

This gene is overexpressed in Lung (47.0) and Breast (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRMT6 Gene

SOURCE GeneReport for Unigene cluster for TRMT6 Gene Hs.128791

mRNA Expression by UniProt/SwissProt for TRMT6 Gene

Tissue specificity: Expressed in brain, liver, testis and ovary.
genes like me logo Genes that share expression patterns with TRMT6: view

Protein tissue co-expression partners for TRMT6 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TRMT6 Gene

Orthologs for TRMT6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRMT6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRMT6 35
  • 92.35 (n)
  • 93.36 (a)
TRMT6 36
  • 93 (a)
(Mus musculus)
Mammalia Trmt6 35
  • 86.09 (n)
  • 85.69 (a)
Trmt6 16
Trmt6 36
  • 85 (a)
(Pan troglodytes)
Mammalia TRMT6 35
  • 99.66 (n)
  • 99.6 (a)
TRMT6 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Trmt6 35
  • 87.37 (n)
  • 86.35 (a)
(Canis familiaris)
Mammalia TRMT6 36
  • 93 (a)
(Monodelphis domestica)
Mammalia TRMT6 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
-- 36
  • 80 (a)
(Gallus gallus)
Aves TRMT6 35
  • 74.32 (n)
  • 75.54 (a)
TRMT6 36
  • 72 (a)
(Anolis carolinensis)
Reptilia TRMT6 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.254 35
trmt6 35
  • 67.31 (n)
  • 68.8 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5761 35
(Danio rerio)
Actinopterygii trmt6 35
  • 62.15 (n)
  • 62.3 (a)
trmt6 36
  • 60 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009904 35
  • 44.99 (n)
  • 33.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9596 35
  • 45.42 (n)
  • 33 (a)
CG9596 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea ZK858.7 35
  • 44.67 (n)
  • 30.67 (a)
ZK858.7 36
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GCD10 36
  • 23 (a)
GCD10 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G45730 35
  • 47.4 (n)
  • 34.02 (a)
(Oryza sativa)
Liliopsida Os04g0112300 35
  • 46.03 (n)
  • 32.92 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for TRMT6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRMT6 Gene

Gene Tree for TRMT6 (if available)
Gene Tree for TRMT6 (if available)

Paralogs for TRMT6 Gene

No data available for Paralogs for TRMT6 Gene

Variants for TRMT6 Gene

Sequence variations from dbSNP and Humsavar for TRMT6 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs6139876 - 5,942,577(+) TTCCT(C/T)CAGTG reference, missense
rs451571 - 5,942,558(+) CTTGT(C/T)CAGAA reference, missense
rs35203742 - 5,942,456(-) GGGGC(C/T)TAAAG reference, missense
rs180480 -- 5,940,821(-) AATTG(G/T)CTGGG intron-variant
rs183535 -- 5,937,642(-) GAACT(A/G)TATCA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TRMT6 Gene

Variant ID Type Subtype PubMed ID
nsv833905 CNV Gain 17160897
nsv819052 CNV Loss 19587683

Variation tolerance for TRMT6 Gene

Residual Variation Intolerance Score: 9.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.41; 85.59% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TRMT6 Gene

Disorders for TRMT6 Gene

Relevant External Links for TRMT6

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TRMT6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRMT6 Gene

Publications for TRMT6 Gene

  1. The bipartite structure of the tRNA m1A58 methyltransferase from S. cerevisiae is conserved in humans. (PMID: 16043508) Ozanick S. … Anderson J.T. (RNA 2005) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for TRMT6 Gene

Sources for TRMT6 Gene