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Aliases for TRMT6 Gene

Aliases for TRMT6 Gene

  • TRNA Methyltransferase 6 2 3 5
  • TRNA(M1A58)MTase Subunit TRM6 3 4
  • TRNA (Adenine(58)-N(1))-Methyltransferase Non-Catalytic Subunit TRM6 3
  • TRNA Methyltransferase 6 Homolog (S. Cerevisiae) 2
  • TRNA(M1A58)-Methyltransferase Subunit TRM6 4
  • TRNA Methyltransferase 6 Homolog 3
  • KIAA1153 4
  • CGI-09 3
  • Gcd10p 3
  • GCD10 3
  • TRM6 4

External Ids for TRMT6 Gene

Previous GeneCards Identifiers for TRMT6 Gene

  • GC20M005867
  • GC20M005875
  • GC20M005917

Summaries for TRMT6 Gene

Entrez Gene Summary for TRMT6 Gene

  • This gene encodes a member of the tRNA methyltransferase 6 protein family. A similar protein in yeast is part of a two component methyltransferase, which is involved in the posttranslational modification that produces the modified nucleoside 1-methyladenosine in tRNAs. Modified 1-methyladenosine influences initiator methionine stability and may be involved in the replication of human immunodeficiency virus type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for TRMT6 Gene

TRMT6 (TRNA Methyltransferase 6) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. GO annotations related to this gene include poly(A) RNA binding and translation initiation factor activity.

UniProtKB/Swiss-Prot for TRMT6 Gene

  • Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

Additional gene information for TRMT6 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT6 Gene

Genomics for TRMT6 Gene

Regulatory Elements for TRMT6 Gene

Enhancers for TRMT6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H005641 2 FANTOM5 Ensembl ENCODE dbSUPER 17.4 +299.4 299353 18.9 HDGF PKNOX1 FOXA2 SIN3A YBX1 ZNF121 GATA2 ZNF207 FOS ATF7 GPCPD1 TRMT6 C20orf196 PROKR2 LOC105372514
GH20H005687 1.6 FANTOM5 Ensembl dbSUPER 17.3 +261.8 261758 2 ELF3 FOXA2 ATF1 MLX ARID4B RAD21 DNMT3B THRB RARA SLC30A9 GPCPD1 TRMT6 MCM8 CHGB LOC105372514
GH20H005607 1.9 FANTOM5 ENCODE dbSUPER 14.4 +339.6 339648 6 HDGF FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 GPCPD1 TRMT6 LOC643406 CDS2 LINC00654 C20orf196 EIF4EP1
GH20H005843 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +106.5 106493 1.4 PKNOX1 FOXA2 SIN3A GLIS2 FOS ATF7 RUNX3 SP3 JUNB TSHZ1 RNU1-55P CHGB TRMT6 MCM8 GC20P005890 C20orf196
GH20H005845 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +104.3 104269 2.4 INSM2 KLF17 FEZF1 BMI1 ZEB1 ZNF366 SCRT2 ATF7 RCOR1 RUNX3 CHGB RNU1-55P MCM8 TRMT6 GC20P005890 C20orf196
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRMT6 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRMT6 Gene

Genomic Locations for TRMT6 Gene
13,324 bases
Minus strand

Genomic View for TRMT6 Gene

Genes around TRMT6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRMT6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRMT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT6 Gene

Proteins for TRMT6 Gene

  • Protein details for TRMT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6
    Protein Accession:
    Secondary Accessions:
    • B4DUV6
    • Q76P92
    • Q9BQV5
    • Q9ULR7
    • Q9Y2Z8

    Protein attributes for TRMT6 Gene

    497 amino acids
    Molecular mass:
    55799 Da
    Quaternary structure:
    • Heterotetramer; composed of two copies of TRMT6 and two copies of TRMT61A.
    • Sequence=BAA86467.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA86467.1; Type=Frameshift; Positions=319; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRMT6 Gene

    Alternative splice isoforms for TRMT6 Gene


neXtProt entry for TRMT6 Gene

Post-translational modifications for TRMT6 Gene

  • Ubiquitination at posLast=112112 and Lys273
  • Modification sites at PhosphoSitePlus

Other Protein References for TRMT6 Gene

No data available for DME Specific Peptides for TRMT6 Gene

Domains & Families for TRMT6 Gene

Gene Families for TRMT6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TRMT6 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRM6/GCD10 family.
  • Belongs to the TRM6/GCD10 family.
genes like me logo Genes that share domains with TRMT6: view

Function for TRMT6 Gene

Molecular function for TRMT6 Gene

UniProtKB/Swiss-Prot Function:
Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

Gene Ontology (GO) - Molecular Function for TRMT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
genes like me logo Genes that share ontologies with TRMT6: view
genes like me logo Genes that share phenotypes with TRMT6: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRMT6 Gene

Localization for TRMT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRMT6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRMT6 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TRMT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0031515 tRNA (m1A) methyltransferase complex IEA --
genes like me logo Genes that share ontologies with TRMT6: view

Pathways & Interactions for TRMT6 Gene

genes like me logo Genes that share pathways with TRMT6: view

Pathways by source for TRMT6 Gene

Gene Ontology (GO) - Biological Process for TRMT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006400 tRNA modification TAS --
GO:0008033 tRNA processing IEA --
GO:0030488 tRNA methylation IEA --
genes like me logo Genes that share ontologies with TRMT6: view

No data available for SIGNOR curated interactions for TRMT6 Gene

Drugs & Compounds for TRMT6 Gene

No Compound Related Data Available

Transcripts for TRMT6 Gene

Unigene Clusters for TRMT6 Gene

TRNA methyltransferase 6 homolog (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP3: - -

Relevant External Links for TRMT6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRMT6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRMT6 Gene

Protein differential expression in normal tissues from HIPED for TRMT6 Gene

This gene is overexpressed in Lung (47.0) and Breast (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRMT6 Gene

Protein tissue co-expression partners for TRMT6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRMT6 Gene:


SOURCE GeneReport for Unigene cluster for TRMT6 Gene:


mRNA Expression by UniProt/SwissProt for TRMT6 Gene:

Tissue specificity: Expressed in brain, liver, testis and ovary.

Evidence on tissue expression from TISSUES for TRMT6 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with TRMT6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRMT6 Gene

Orthologs for TRMT6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRMT6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRMT6 33 34
  • 99.66 (n)
(Canis familiaris)
Mammalia TRMT6 34
  • 93 (a)
(Bos Taurus)
Mammalia TRMT6 33 34
  • 92.35 (n)
(Rattus norvegicus)
Mammalia Trmt6 33
  • 87.37 (n)
(Mus musculus)
Mammalia Trmt6 33 16 34
  • 86.09 (n)
(Monodelphis domestica)
Mammalia TRMT6 34
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 80 (a)
-- 34
  • 67 (a)
(Gallus gallus)
Aves TRMT6 33 34
  • 74.32 (n)
(Anolis carolinensis)
Reptilia TRMT6 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trmt6 33
  • 67.31 (n)
Str.254 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.5761 33
(Danio rerio)
Actinopterygii trmt6 33 34
  • 62.15 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9596 33 34
  • 45.42 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009904 33
  • 44.99 (n)
(Caenorhabditis elegans)
Secernentea ZK858.7 33 34
  • 44.67 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GCD10 34 36
  • 23 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G45730 33
  • 47.4 (n)
(Oryza sativa)
Liliopsida Os04g0112300 33
  • 46.03 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 39 (a)
Species where no ortholog for TRMT6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRMT6 Gene

Gene Tree for TRMT6 (if available)
Gene Tree for TRMT6 (if available)

Paralogs for TRMT6 Gene

No data available for Paralogs for TRMT6 Gene

Variants for TRMT6 Gene

Sequence variations from dbSNP and Humsavar for TRMT6 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000293469 -- 5,949,977(+) ATTCT(A/G)GGGAA intron-variant, upstream-variant-2KB
rs1000402164 -- 5,949,304(+) TGCAA(C/T)GAGCC intron-variant, upstream-variant-2KB
rs1000696039 -- 5,938,532(+) CAAAA(C/G)GGTTA utr-variant-3-prime
rs1000922968 -- 5,943,797(+) TTGAT(C/T)GCTTT intron-variant
rs1001425755 -- 5,940,761(+) TACAG(G/T)CACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRMT6 Gene

Variant ID Type Subtype PubMed ID
nsv819052 CNV loss 19587683
nsv833905 CNV gain 17160897

Variation tolerance for TRMT6 Gene

Residual Variation Intolerance Score: 9.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.41; 85.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRMT6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRMT6 Gene

Disorders for TRMT6 Gene

Relevant External Links for TRMT6

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TRMT6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRMT6 Gene

Publications for TRMT6 Gene

  1. The bipartite structure of the tRNA m1A58 methyltransferase from S. cerevisiae is conserved in humans. (PMID: 16043508) Ozanick S … Anderson JT (RNA (New York, N.Y.) 2005) 2 3 4 60
  2. Genome-wide association studies identify loci associated with age at menarche and age at natural menopause. (PMID: 19448621) He C … Chasman DI (Nature genetics 2009) 3 45 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 60

Products for TRMT6 Gene

Sources for TRMT6 Gene

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