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Aliases for TRMT6 Gene

Aliases for TRMT6 Gene

  • TRNA Methyltransferase 6 2 3
  • TRNA(M1A58)MTase Subunit TRM6 3 4
  • TRNA (Adenine(58)-N(1))-Methyltransferase Non-Catalytic Subunit TRM6 3
  • TRNA Methyltransferase 6 Homolog (S. Cerevisiae) 2
  • TRNA(M1A58)-Methyltransferase Subunit TRM6 4
  • TRNA Methyltransferase 6 Homolog 3
  • KIAA1153 4
  • CGI-09 3
  • Gcd10p 3
  • GCD10 3
  • TRM6 4

External Ids for TRMT6 Gene

Summaries for TRMT6 Gene

Entrez Gene Summary for TRMT6 Gene

  • This gene encodes a member of the tRNA methyltransferase 6 protein family. A similar protein in yeast is part of a two component methyltransferase, which is involved in the posttranslational modification that produces the modified nucleoside 1-methyladenosine in tRNAs. Modified 1-methyladenosine influences initiator methionine stability and may be involved in the replication of human immunodeficiency virus type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for TRMT6 Gene

TRMT6 (TRNA Methyltransferase 6) is a Protein Coding gene. GO annotations related to this gene include translation initiation factor activity.

UniProtKB/Swiss-Prot for TRMT6 Gene

  • Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT6 Gene

Genomics for TRMT6 Gene

Genomic Location for TRMT6 Gene

Start:
5,937,235 bp from pter
End:
5,950,558 bp from pter
Size:
13,324 bases
Orientation:
Minus strand

Genomic View for TRMT6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRMT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT6 Gene

Regulatory Elements for TRMT6 Gene

Proteins for TRMT6 Gene

  • Protein details for TRMT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJA5-TRM6_HUMAN
    Recommended name:
    tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6
    Protein Accession:
    Q9UJA5
    Secondary Accessions:
    • B4DUV6
    • Q76P92
    • Q9BQV5
    • Q9ULR7
    • Q9Y2Z8

    Protein attributes for TRMT6 Gene

    Size:
    497 amino acids
    Molecular mass:
    55799 Da
    Quaternary structure:
    • tRNA (adenine-N(1)-)-methyltransferase is a heterodimer of TRM6 and TRM61.
    SequenceCaution:
    • Sequence=BAA86467.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA86467.1; Type=Frameshift; Positions=319; Evidence={ECO:0000305};

    Alternative splice isoforms for TRMT6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRMT6 Gene

Proteomics data for TRMT6 Gene at MOPED

Post-translational modifications for TRMT6 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys112 and Lys273

Other Protein References for TRMT6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRMT6 Gene

Domains for TRMT6 Gene

Protein Domains for TRMT6 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9UJA5

UniProtKB/Swiss-Prot:

TRM6_HUMAN
Family:
  • Belongs to the TRM6/GCD10 family.:
    • Q9UJA5
genes like me logo Genes that share domains with TRMT6: view

No data available for Gene Families for TRMT6 Gene

Function for TRMT6 Gene

Molecular function for TRMT6 Gene

UniProtKB/Swiss-Prot Function: Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

Gene Ontology (GO) - Molecular Function for TRMT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 translation initiation factor activity --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with TRMT6: view

Phenotypes for TRMT6 Gene

GenomeRNAi human phenotypes for TRMT6:
genes like me logo Genes that share phenotypes with TRMT6: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TRMT6 Gene

Localization for TRMT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRMT6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRMT6 Gene COMPARTMENTS Subcellular localization image for TRMT6 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TRMT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0031515 tRNA (m1A) methyltransferase complex IEA --
genes like me logo Genes that share ontologies with TRMT6: view

Pathways for TRMT6 Gene

SuperPathways for TRMT6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRMT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006413 translational initiation --
GO:0006446 regulation of translational initiation --
GO:0008033 tRNA processing --
GO:0030488 tRNA methylation IEA --
genes like me logo Genes that share ontologies with TRMT6: view

No data available for Pathways by source for TRMT6 Gene

Transcripts for TRMT6 Gene

Unigene Clusters for TRMT6 Gene

TRNA methyltransferase 6 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1:
SP2:
SP3: - -
SP4:

Relevant External Links for TRMT6 Gene

GeneLoc Exon Structure for
TRMT6
ECgene alternative splicing isoforms for
TRMT6

Expression for TRMT6 Gene

mRNA expression in normal human tissues for TRMT6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRMT6 Gene

SOURCE GeneReport for Unigene cluster for TRMT6 Gene Hs.128791

mRNA Expression by UniProt/SwissProt for TRMT6 Gene

Q9UJA5-TRM6_HUMAN
Tissue specificity: Expressed in brain, liver, testis and ovary.
genes like me logo Genes that share expressions with TRMT6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TRMT6 Gene

Orthologs for TRMT6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRMT6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRMT6 35
  • 99.66 (n)
  • 99.6 (a)
TRMT6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRMT6 35
  • 92.35 (n)
  • 93.36 (a)
TRMT6 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRMT6 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trmt6 35
  • 86.09 (n)
  • 85.69 (a)
Trmt6 16
Trmt6 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRMT6 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Trmt6 35
  • 87.37 (n)
  • 86.35 (a)
chicken
(Gallus gallus)
Aves TRMT6 35
  • 74.32 (n)
  • 75.54 (a)
TRMT6 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRMT6 36
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5761 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.254 35
trmt6 35
  • 67.31 (n)
  • 68.8 (a)
zebrafish
(Danio rerio)
Actinopterygii trmt6 35
  • 62.15 (n)
  • 62.3 (a)
trmt6 36
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009904 35
  • 44.99 (n)
  • 33.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9596 35
  • 45.42 (n)
  • 33 (a)
CG9596 36
  • 30 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK858.7 35
  • 44.67 (n)
  • 30.67 (a)
ZK858.7 36
  • 26 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GCD10 36
  • 23 (a)
OneToOne
GCD10 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G45730 35
  • 47.4 (n)
  • 34.02 (a)
rice
(Oryza sativa)
Liliopsida Os04g0112300 35
  • 46.03 (n)
  • 32.92 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToOne
Species with no ortholog for TRMT6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRMT6 Gene

ENSEMBL:
Gene Tree for TRMT6 (if available)
TreeFam:
Gene Tree for TRMT6 (if available)

Paralogs for TRMT6 Gene

No data available for Paralogs for TRMT6 Gene

Variants for TRMT6 Gene

Sequence variations from dbSNP and Humsavar for TRMT6 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs180480 -- 5,940,821(-) AATTG(G/T)CTGGG intron-variant
rs183535 -- 5,937,642(-) GAACT(A/G)TATCA downstream-variant-500B
rs236167 -- 5,937,612(-) GACCA(A/G)TTCTC downstream-variant-500B
rs236168 -- 5,937,744(-) ATACA(C/T)AGATA downstream-variant-500B
rs236169 -- 5,937,827(-) CCTCT(A/G)TGGTC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TRMT6 Gene

Variant ID Type Subtype PubMed ID
nsv833905 CNV Gain 17160897
nsv819052 CNV Loss 19587683

Relevant External Links for TRMT6 Gene

HapMap Linkage Disequilibrium report
TRMT6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRMT6 Gene

Disorders for TRMT6 Gene

Relevant External Links for TRMT6

Genetic Association Database (GAD)
TRMT6
genes like me logo Genes that share disorders with TRMT6: view

No data available for UniProtKB/Swiss-Prot for TRMT6 Gene

Publications for TRMT6 Gene

  1. The bipartite structure of the tRNA m1A58 methyltransferase from S. cerevisiae is conserved in humans. (PMID: 16043508) Ozanick S. … Anderson J.T. (RNA 2005) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 3 4
  5. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4

Products for TRMT6 Gene

Sources for TRMT6 Gene

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