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TRMT6 Gene

protein-coding   GIFtS: 49
GCID: GC20M005917

TRNA Methyltransferase 6 Homolog (S. Cerevisiae)

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TRNA Methyltransferase 6 Homolog (S. Cerevisiae)1 2     TRNA (Adenine(58)-N(1))-Methyltransferase Non-Catalytic Subunit TRM62
TRNA(M1A58)MTase Subunit TRM62 3     KIAA11533
GCD102     TRM63
Gcd10p2     TRNA(M1A58)-Methyltransferase Subunit TRM63

External Ids:    HGNC: 209001   Entrez Gene: 516052   Ensembl: ENSG000000891957   UniProtKB: Q9UJA53   

Export aliases for TRMT6 gene to outside databases

Previous GC identifers: GC20M005867 GC20M005875


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRMT6 Gene:
This gene encodes a member of the tRNA methyltransferase 6 protein family. A similar protein in yeast is part of a
two component methyltransferase, which is involved in the posttranslational modification that produces the
modified nucleoside 1-methyladenosine in tRNAs. Modified 1-methyladenosine influences initiator methionine
stability and may be involved in the replication of human immunodeficiency virus type 1. Alternative splicing
results in multiple transcript variants. (provided by RefSeq, Jul 2013)

GeneCards Summary for TRMT6 Gene:
TRMT6 (tRNA methyltransferase 6 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with TRMT6 include malaria. GO annotations related to this gene include translation initiation factor activity.

UniProtKB/Swiss-Prot: TRM6_HUMAN, Q9UJA5
Function: Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of
N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NT_011387.9  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRMT6 gene promoter:
         RFX1   STAT1   HOXA3   AML1a   p53   POU3F1   STAT1beta   POU3F2   STAT1alpha   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRMT6 promoter sequence
   Search Chromatin IP Primers for TRMT6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRMT6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p12.3   Ensembl cytogenetic band:  20p12.3   HGNC cytogenetic band: 20p12.3

TRMT6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRMT6 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M005917:  view genomic region     (about GC identifiers)

Start:
5,917,881 bp from pter      End:
5,931,182 bp from pter
Size:
13,302 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRM6_HUMAN, Q9UJA5 (See protein sequence)
Recommended Name: tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6  
Size: 497 amino acids; 55799 Da
Subunit: tRNA (adenine-N(1)-)-methyltransferase is a heterodimer of TRM6 and TRM61
Sequence caution: Sequence=BAA86467.1; Type=Erroneous initiation; Sequence=BAA86467.1; Type=Frameshift;
Positions=319;
Secondary accessions: Q76P92 Q9BQV5 Q9ULR7 Q9Y2Z8
Alternative splicing: 3 isoforms:  Q9UJA5-1   Q9UJA5-2   Q9UJA5-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRMT6: NX_Q9UJA5

Explore proteomics data for TRMT6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys112, Lys273
  • Modification sites at PhosphoSitePlus

  • See TRMT6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001268396.1  NP_057023.2  

    ENSEMBL proteins: 
     ENSP00000203001   ENSP00000392070  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR007316 EIF3_gamma
     IPR017423 tRNA_m1A_mtfrase

    Graphical View of Domain Structure for InterPro Entry Q9UJA5

    ProtoNet protein and cluster: Q9UJA5

    UniProtKB/Swiss-Prot: TRM6_HUMAN, Q9UJA5
    Similarity: Belongs to the TRM6/GCD10 family


    TRMT6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRM6_HUMAN, Q9UJA5
    Function: Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of
    N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003743translation initiation factor activity IEA--
    GO:0008168methyltransferase activity ----
    GO:0044822poly(A) RNA binding IDA--
         
    TRMT6 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TRMT6:
     Decreased cell number  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRMT6
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    2 qRT-PCR Assays for microRNAs that regulate TRMT6:
    hsa-miR-4324 hsa-miR-137
    SwitchGear 3'UTR luciferase reporter plasmidTRMT6 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRM6_HUMAN, Q9UJA5: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    TRMT6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRMT6
    Interactions:

        Search GeneGlobe Interaction Network for TRMT6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRMT6 (Q9UJA53 ENSP000002030014) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRMT61AQ96FX73, ENSP000003743994I2D: score=4 STRING: ENSP00000374399
    RPP30P783463, ENSP000003891824I2D: score=1 STRING: ENSP00000389182
    TNIKQ9UKE53I2D: score=3 
    PRKAB2O437413I2D: score=1 
    UBA5Q9GZZ93I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006413translational initiation ----
    GO:0006446regulation of translational initiation IEA--
    GO:0008033tRNA processing IEA--

    TRMT6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRMT6 (TRM6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TRMT6 gene (2 alternative transcripts): 
    NM_001281467.1  NM_015939.4  

    Unigene Cluster for TRMT6:

    TRNA methyltransferase 6 homolog (S. cerevisiae)
    Hs.128791  [show with all ESTs]
    Unigene Representative Sequence: AB032979
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000473131(uc010gbo.1) ENST00000466974(uc010gbn.1) ENST00000203001(uc002wmh.1 uc010zra.1)
    ENST00000493972 ENST00000453074
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate TRMT6:
    hsa-miR-4324 hsa-miR-137
    SwitchGear 3'UTR luciferase reporter plasmidTRMT6 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB032979.1 AF132943.1 AK000613.1 AK300812.1 AK308648.1 AK309205.1 BC001262.1 

    8 DOTS entries:

    DT.455296  DT.100758272  DT.100758279  DT.91724096  DT.95371445  DT.100758275  DT.100758276  DT.92425610 

    Selected AceView cDNA sequences (see all 119):

    CB131654 BM989199 BP364288 BQ007100 AI379353 AA812282 NM_015939 CB241210 
    BQ083075 BF195794 BQ009182 AW674581 CR607627 AB032979 AI917089 BM998619 
    CA774794 BM679607 CA312079 CR601280 AI357153 BQ943164 AW590755 BC001262 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TRMT6    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:                                                                                                
    SP2:                                                                                                
    SP3:                          -     -                                                               
    SP4:                                                                                                


    ECgene alternative splicing isoforms for TRMT6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRMT6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGAAATTT
    TRMT6 Expression
    About this image

    TRMT6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRMT6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.128791

    UniProtKB/Swiss-Prot: TRM6_HUMAN, Q9UJA5
    Tissue specificity: Expressed in brain, liver, testis and ovary

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TRMT6 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trmt61 , 5 tRNA methyltransferase 6 homolog (S. cerevisiae)5
    tRNA methyltransferase 61
    86.09(n)1
    85.69(a)1
      2 (64.74 cM)5
    669261  NM_175113.31  NP_780322.21 
     1328042075 
    chicken
    (Gallus gallus)
    Aves TRMT61 tRNA methyltransferase 6 homolog (S. cerevisiae) 74.32(n)
    75.54(a)
      421313  NM_001031041.2  NP_001026212.2 
    lizard
    (Anolis carolinensis)
    Reptilia TRMT66
    tRNA methyltransferase 6 homolog (S. cerevisiae)
    70(a)
    1 ↔ 1
    1(129395718-129411859)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.57612 Xenopus laevis transcribed sequence with moderate similarity more 75.79(n)    BU901066.1 
    zebrafish
    (Danio rerio)
    Actinopterygii trmt61 tRNA methyltransferase 6 homolog (S. cerevisiae) 62.15(n)
    62.3(a)
      563475  NM_001037392.1  NP_001032469.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG95961 CG9596 45.42(n)
    33(a)
      33920  NM_205916.2  NP_995638.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK858.71 ZK858.7 44.67(n)
    30.67(a)
      259389  NM_060051.3  NP_492452.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GCD10(YNL062C)4 Subunit of tRNA (1-methyladenosine) methyltransferase more   --   14(510212-508776) 855663  NP_014337.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G457301 AT2G45730 47.4(n)
    34.02(a)
      819181  NM_130136.3  NP_566054.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g01123001 Os04g0112300 46.03(n)
    32.92(a)
      4334938  NM_001058572.1  NP_001052037.1 


    ENSEMBL Gene Tree for TRMT6 (if available)
    TreeFam Gene Tree for TRMT6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRMT6 (see all 303)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs730851731,2
    C,F--5917996(+) TCCTTG/ACTGTA 1 -- ds50014Minor allele frequency- A:0.25CSA WA EA 242
    rs1156168981,2
    F--5918168(+) GTAACC/AATCTA 1 -- ds50011Minor allele frequency- A:0.06WA 118
    rs1816559291,2
    --5918194(+) TTCAGC/GATTAA 1 -- ds50010--------
    rs169915391,2
    C,F,H--5918196(+) CAGCAT/CTAATA 1 -- ds500123Minor allele frequency- C:0.06NA NS EA WA 2902
    rs2361671,2
    C,F,O,H--5918258(-) GACCAG/ATTCTC 1 -- ds500122Minor allele frequency- A:0.12MN NS EA NA WA CSA 1123
    rs1835351,2
    C,F,O,A,H--5918288(-) GAACTG/ATATCA 1 -- ds500127Minor allele frequency- A:0.43MN NS EA NA WA CSA 2843
    rs1861238451,2
    --5918299(+) AAATAA/C/GACTGC 1 -- ds50010--------
    rs2361681,2
    C--5918390(-) ATACAT/CAGATA 1 -- ds50018Minor allele frequency- C:0.21NA WA CSA EA 368
    rs1425268591,2
    --5918435(+) ATATAC/GATATG 1 -- ds50010--------
    rs1460412391,2
    --5918458(+) AATGTC/GTATCC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for TRMT6 (5917881 - 5931182 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TRMT6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv819052CNV Loss19587683
    nsv833905CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRMT6
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for TRMT6:    
    About MalaCards
    malaria


    TRMT6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TRMT6

    Export disorders for TRMT6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRMT6 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with TRMT6)
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    1. The bipartite structure of the tRNA m1A58 methyltransferase from S. cerevisiae is conserved in humans. (PubMed id 16043508)1, 2, 3 Ozanick S.... Anderson J.T. (RNA 2005)
    2. Genome-wide association studies identify loci associated with age at menarche and age at natural menopause. (PubMed id 19448621)1, 4 He C....Chasman D.I. (Nat. Genet. 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    6. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    7. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2 Hirosawa M.... Ohara O. (DNA Res. 1999)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51605 HGNC: 20900 AceView: CGI-09 Ensembl:ENSG00000089195 euGenes: HUgn51605
    ECgene: TRMT6 H-InvDB: TRMT6

    (According to HUGE)
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    HUGE: KIAA1153

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRMT6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRMT6 gene:
    Search GeneIP for patents involving TRMT6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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