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TRMT5 Gene

protein-coding   GIFtS: 55
GCID: GC14M061438

TRNA Methyltransferase 5

(Previous names: KIAA1393, tRNA methyltransferase 5 homolog (S. cerevisiae))
(Previous symbol: KIAA1393)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TRNA Methyltransferase 51 2     TRNA Methyltransferase 5 Homolog (S. Cerevisiae)1
KIAA13931 2 3 5     TRM5 TRNA Methyltransferase 5 Homolog2
TRM52 3 5     TRNA (Guanine-N(1)-)-Methyltransferase2
TRNA (Guanine(37)-N1)-Methyltransferase1 2     TRNA-N1G37 Methyltransferase2
M1G-methyltransferase2 3     EC 2.1.1.2283
TRNA [GM37] Methyltransferase2 3     TRNA Methyltransferase 5 Homolog3

External Ids:    HGNC: 231411   Entrez Gene: 575702   Ensembl: ENSG000001268147   OMIM: 6110235   UniProtKB: Q32P413   

Export aliases for TRMT5 gene to outside databases

Previous GC identifers: GC14M060508 GC14M041601


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRMT5 Gene:
tRNAs contain as many as 13 or 14 nucleotides that are modified posttranscriptionally by enzymes that are highly
specific for particular nucleotides in the tRNA structure. TRMT5 methylates the N1 position of guanosine-37 (G37)
in selected tRNAs using S-adenosyl methionine (Brule et al., 2004 (PubMed 15248782)).(supplied by OMIM, Mar 2008)

GeneCards Summary for TRMT5 Gene:
TRMT5 (tRNA methyltransferase 5) is a protein-coding gene. GO annotations related to this gene include tRNA (guanine(37)-N(1))-methyltransferase activity.

UniProtKB/Swiss-Prot: TRM5_HUMAN, Q32P41
Function: Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs.
Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step
in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for
accurate decoding




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRMT5 gene promoter:
         Nkx3-1   TBP   Nkx3-1 v4   AML1a   HSF1 (long)   Nkx3-1 v1   Nkx3-1 v2   FOXO4   Nkx3-1 v3   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRMT5 promoter sequence
   Search Chromatin IP Primers for TRMT5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRMT5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.1   Ensembl cytogenetic band:  14q23.1   HGNC cytogenetic band: 14q23.1

TRMT5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRMT5 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M061438:  view genomic region     (about GC identifiers)

Start:
61,438,159 bp from pter      End:
61,448,076 bp from pter
Size:
9,918 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TRM5_HUMAN, Q32P41 (See protein sequence)
Recommended Name: tRNA (guanine(37)-N1)-methyltransferase  
Size: 509 amino acids; 58246 Da
Subunit: Monomer
Secondary accessions: B2RN19 Q9P2F4

Explore the universe of human proteins at neXtProt for TRMT5: NX_Q32P41

Explore proteomics data for TRMT5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TRMT5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065861.2  
    ENSEMBL proteins: 
     ENSP00000261249   ENSP00000452567   ENSP00000451666  

    TRMT5 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TRMT5

     
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    antibodies-online proteins for TRMT5 (81 products) 

     
    antibodies-online peptides for TRMT5

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    Cloud-Clone Corp. ELISAs for TRMT5
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    antibodies-online kits for TRMT5 (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR003402 tRNA_Trfase_Trm5/Tyw2
     IPR025792 tRNA_Gua_MeTrfase_euk

    Graphical View of Domain Structure for InterPro Entry Q32P41

    ProtoNet protein and cluster: Q32P41

    1 Blocks protein domain: IPB003402 Family of unknown function Met10

    UniProtKB/Swiss-Prot: TRM5_HUMAN, Q32P41
    Similarity: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family


    Find genes that share domains with TRMT5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRM5_HUMAN, Q32P41
    Function: Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs.
    Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step
    in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for
    accurate decoding
    Catalytic activity: S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine +
    N(1)-methylguanine(37) in tRNA

         Enzyme Number (IUBMB): EC 2.1.1.2281

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016740transferase activity ----
    GO:0052906tRNA (guanine(37)-N(1))-methyltransferase activity IEA--
         
    Find genes that share ontologies with TRMT5           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TRMT5:
     Decreased p24 protein expressi  Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TRMT5

    miRNA
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    miRTarBase miRNAs that target TRMT5:
    hsa-mir-222-3p (MIRT046645)

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    7 qRT-PCR Assays for microRNAs that regulate TRMT5:
    hsa-miR-3163 hsa-miR-205* hsa-miR-34b hsa-miR-32* hsa-miR-578 hsa-miR-4282 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidTRMT5 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRM5_HUMAN, Q32P41: Mitochondrion matrix (By similarity). Nucleus (By similarity). Cytoplasm (By similarity).
    Note=Predominantly in the mitochondria and in the nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion2
    nucleus2
    cytosol1
    endoplasmic reticulum1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005759mitochondrial matrix IEA--

    Find genes that share ontologies with TRMT5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRMT5
    Interactions:

        Search GeneGlobe Interaction Network for TRMT5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for TRMT5 (Q32P413 ENSP000002612494) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAP2P401233, ENSP000002299224I2D: score=5 STRING: ENSP00000229922
    WIPI1Q5MNZ93, ENSP000002621394I2D: score=3 STRING: ENSP00000262139
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    VPS35Q96QK13, ENSP000002991384I2D: score=3 STRING: ENSP00000299138
    HSP90AA1P079003I2D: score=3 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRMT5 (TRM5)

    1 HMDB Compound for TRMT5    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRMT5 gene: 
    NM_020810.2  

    Unigene Cluster for TRMT5:

    TRNA methyltransferase 5 homolog (S. cerevisiae)
    Hs.380159  [show with all ESTs]
    Unigene Representative Sequence: NM_020810
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261249(uc001xff.4) ENST00000553903 ENST00000555420
    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate TRMT5:
    hsa-miR-3163 hsa-miR-205* hsa-miR-34b hsa-miR-32* hsa-miR-578 hsa-miR-4282 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidTRMT5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TRMT5
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRMT5
      QuantiTect SYBR Green Assays in human, mouse, rat TRMT5
      QuantiFast Probe-based Assays in human, mouse, rat TRMT5

    Additional mRNA sequence: 

    AB037814.1 AK293158.1 BC029638.1 BC063551.1 BC108284.1 BC136606.1 BC136607.1 

    3 DOTS entries:

    DT.91778591  DT.86857049  DT.40115154 

    Selected AceView cDNA sequences (see all 66):

    AI619642 NM_020810 BU173034 AA971564 BC029638 CA432338 BQ050607 AW248874 
    AW340057 BM797689 N91644 BC063551 BF055348 BQ030409 BQ012657 BG742927 
    BG702371 BG740985 AW273886 BF037340 AA992906 BM819962 AA868512 AI190282 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for TRMT5    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5
    SP1:        -                                 
    SP2:                                          


    ECgene alternative splicing isoforms for TRMT5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRMT5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTGTTTATG
    TRMT5 Expression
    About this image


    TRMT5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    TRMT5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRMT5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.380159
        Custom PCR Arrays for TRMT5
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TRMT5 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trmt51 , 5 TRM5 tRNA methyltransferase 5 homolog (S. cerevisiae) less5
    TRM5 tRNA methyltransferase 51
    81.7(n)1
    76.55(a)1
      12 (30.42 cM)5
    763571  NM_029580.31  NP_083856.11 
     732804105 
    chicken
    (Gallus gallus)
    Aves TRMT51 tRNA methyltransferase 5 homolog (S. cerevisiae) 68.69(n)
    64.65(a)
      423520  XM_004936445.1  XP_004936502.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRMT56
    tRNA methyltransferase 5
    59(a)
    1 ↔ 1
    GL343261.1(520790-529612)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia trmt51 tRNA methyltransferase 5 65.45(n)
    62.5(a)
      100379699  XM_002939476.2  XP_002939522.2 
    zebrafish
    (Danio rerio)
    Actinopterygii trmt51 TRM5 tRNA methyltransferase 5 homolog (S. cerevisiae) less 59.16(n)
    60.66(a)
      564078  NM_001145583.1  NP_001139055.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG322811 CG32281 50.17(n)
    46.45(a)
      317953  NM_167995.2  NP_728821.2 
    worm
    (Caenorhabditis elegans)
    Secernentea C53A5.171 C53A5.17 47.55(n)
    35.91(a)
      13216595  NM_001269663.1  NP_001256592.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TRM5(YHR070W)4
    TRM51
    tRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and Eukarya less4
    TRM51
    50.89(n)1
    43.8(a)1
      8(234881-236380)4
    8564671, 4  NP_011937.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G561201 AT3G56120 51.18(n)
    39.65(a)
      824778  NM_115470.2  NP_567034.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g06063011 Os02g0606301 55.98(n)
    46.56(a)
      9271157  NM_001186137.1  NP_001173066.1 


    ENSEMBL Gene Tree for TRMT5 (if available)
    TreeFam Gene Tree for TRMT5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRMT5 (see all 194)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs355174121,2
    C--42423194(+) AAGGG-/GATTAAG 1 -- ut311Minor allele frequency- GA:0.00NA 2
    rs1154224871,2
    F--61437666(+) AGTTTA/CGGGTG 1 -- ds50011Minor allele frequency- C:0.04WA 118
    rs1450543911,2
    C--61437728(+) TTAAAA/GCGTTA 1 -- ds50010--------
    rs1891690771,2
    C--61437912(+) TTTGAA/GTTAAG 1 -- ds50010--------
    rs1812981201,2
    --61437985(+) TTTACA/GTGACC 1 -- ds50010--------
    rs1406321051,2
    C--61438256(+) TTAAC-/AGTATA 1 -- ut310--------
    rs1509266471,2
    --61438288(+) CAATGA/GACTAC 1 -- ut310--------
    rs19582811,2
    C,F,H--61438306(-) TATAGC/TGGCTG 1 -- ut31 ese3112Minor allele frequency- G:0.00NS MN EA PA EU CA WA NA CSA 7031
    rs1840133421,2
    --61438315(+) TAAAAC/GCCAAT 1 -- ut310--------
    rs1443876381,2
    C--61438350(+) CAGGG-/AAAGTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TRMT5 (61438159 - 61448076 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TRMT5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2748755CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRMT5
    DNA2.0 Custom Variant and Variant Library Synthesis for TRMT5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611023    OMIM disorders: --


    Find genes that share disorders with TRMT5           About GenesLikeMe

    Genetic Association Database (GAD): TRMT5
    Human Genome Epidemiology (HuGE) Navigator: TRMT5 (1 document)

    Export disorders for TRMT5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRMT5 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with TRMT5)
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    1. Isolation and characterization of the human tRNA-(N1G37) methyltransferase (TRM5) and comparison to the Escherichia coli TrmD protein. (PubMed id 15248782)1, 2, 3, 9 Brule H.... Holmes W.M. (Biochemistry 2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    4. Conservation of structure and mechanism by Trm5 enzymes. (PubMed id 23887145)1 Christian T....Hou Y.M. (RNA 2013)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (J. Infect. Dis. 2010)
    9. Identification of host proteins required for HIV infection through a functional genomic screen. (PubMed id 18187620)1 Brass A.L....Elledge S.J. (Science 2008)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57570 HGNC: 23141 AceView: KIAA1393 Ensembl:ENSG00000126814 euGenes: HUgn57570
    ECgene: TRMT5 H-InvDB: TRMT5

    (According to HUGE)
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    HUGE: KIAA1393

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRMT5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRMT5 gene:
    Search GeneIP for patents involving TRMT5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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