Aliases for TRMT5 Gene
External Ids for TRMT5 Gene
Previous Symbols for TRMT5 Gene
tRNAs contain as many as 13 or 14 nucleotides that are modified posttranscriptionally by enzymes that are highly specific for particular nucleotides in the tRNA structure. TRMT5 methylates the N1 position of guanosine-37 (G37) in selected tRNAs using S-adenosyl methionine (Brule et al., 2004 [PubMed 15248782]).[supplied by OMIM, Mar 2008]
GeneCards Summary for TRMT5 Gene
TRMT5 (TRNA Methyltransferase 5) is a Protein Coding gene. GO annotations related to this gene include tRNA (guanine(37)-N(1))-methyltransferase activity.
UniProtKB/Swiss-Prot for TRMT5 Gene
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5 of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding