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Aliases for TRMT5 Gene

Aliases for TRMT5 Gene

  • TRNA Methyltransferase 5 2 3
  • KIAA1393 2 3 4 6
  • TRM5 3 4 6
  • TRNA (Guanine(37)-N1)-Methyltransferase 2 3
  • TRNA [GM37] Methyltransferase 3 4
  • M1G-Methyltransferase 3 4
  • TRNA Methyltransferase 5 Homolog (S. Cerevisiae) 2
  • TRNA (Guanine-N(1)-)-Methyltransferase 3
  • TRM5 TRNA Methyltransferase 5 Homolog 3
  • TRNA Methyltransferase 5 Homolog 4
  • TRNA-N1G37 Methyltransferase 3
  • EC 2.1.1.228 4

External Ids for TRMT5 Gene

Previous Symbols for TRMT5 Gene

  • KIAA1393

Summaries for TRMT5 Gene

Entrez Gene Summary for TRMT5 Gene

  • tRNAs contain as many as 13 or 14 nucleotides that are modified posttranscriptionally by enzymes that are highly specific for particular nucleotides in the tRNA structure. TRMT5 methylates the N1 position of guanosine-37 (G37) in selected tRNAs using S-adenosyl methionine (Brule et al., 2004 [PubMed 15248782]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TRMT5 Gene

TRMT5 (TRNA Methyltransferase 5) is a Protein Coding gene. GO annotations related to this gene include tRNA (guanine(37)-N(1))-methyltransferase activity.

UniProtKB/Swiss-Prot for TRMT5 Gene

  • Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5 of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT5 Gene

Genomics for TRMT5 Gene

Genomic Location for TRMT5 Gene

Start:
60,971,441 bp from pter
End:
60,981,358 bp from pter
Size:
9,918 bases
Orientation:
Minus strand

Genomic View for TRMT5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRMT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT5 Gene

Regulatory Elements for TRMT5 Gene

Proteins for TRMT5 Gene

  • Protein details for TRMT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q32P41-TRM5_HUMAN
    Recommended name:
    tRNA (guanine(37)-N1)-methyltransferase
    Protein Accession:
    Q32P41
    Secondary Accessions:
    • B2RN19
    • Q9P2F4

    Protein attributes for TRMT5 Gene

    Size:
    509 amino acids
    Molecular mass:
    58246 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for TRMT5 Gene

Proteomics data for TRMT5 Gene at MOPED

Post-translational modifications for TRMT5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRMT5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRMT5 Gene

Domains for TRMT5 Gene

Protein Domains for TRMT5 Gene

UniProtKB/Swiss-Prot:

TRM5_HUMAN
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.:
    • Q32P41
genes like me logo Genes that share domains with TRMT5: view

No data available for Gene Families for TRMT5 Gene

Function for TRMT5 Gene

Molecular function for TRMT5 Gene

UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.
UniProtKB/Swiss-Prot Function: Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5 of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding

Enzyme Numbers (IUBMB) for TRMT5 Gene

Gene Ontology (GO) - Molecular Function for TRMT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0052906 tRNA (guanine(37)-N(1))-methyltransferase activity IEA --
genes like me logo Genes that share ontologies with TRMT5: view

Phenotypes for TRMT5 Gene

GenomeRNAi human phenotypes for TRMT5:
genes like me logo Genes that share phenotypes with TRMT5: view

miRNA for TRMT5 Gene

miRTarBase miRNAs that target TRMT5

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TRMT5 Gene

Localization for TRMT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRMT5 Gene

Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus. {ECO:0000255 HAMAP-Rule:MF_03152}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRMT5 Gene COMPARTMENTS Subcellular localization image for TRMT5 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 1
endoplasmic reticulum 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TRMT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005759 mitochondrial matrix IEA --
genes like me logo Genes that share ontologies with TRMT5: view

Pathways for TRMT5 Gene

SuperPathways for TRMT5 Gene

No Data Available

Interacting Proteins for TRMT5 Gene

Gene Ontology (GO) - Biological Process for TRMT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030488 tRNA methylation IEA --
genes like me logo Genes that share ontologies with TRMT5: view

No data available for Pathways by source for TRMT5 Gene

Compounds for TRMT5 Gene

(1) HMDB Compounds for TRMT5 Gene

Compound Synonyms Cas Number PubMed IDs
S-Adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
29908-03-0
genes like me logo Genes that share compounds with TRMT5: view

Transcripts for TRMT5 Gene

Unigene Clusters for TRMT5 Gene

TRNA methyltransferase 5 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5
SP1: -
SP2:

Relevant External Links for TRMT5 Gene

GeneLoc Exon Structure for
TRMT5
ECgene alternative splicing isoforms for
TRMT5

Expression for TRMT5 Gene

mRNA expression in normal human tissues for TRMT5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TRMT5 Gene

SOURCE GeneReport for Unigene cluster for TRMT5 Gene Hs.380159

genes like me logo Genes that share expressions with TRMT5: view

Orthologs for TRMT5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRMT5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRMT5 36
  • 99.41 (n)
  • 99.21 (a)
TRMT5 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRMT5 36
  • 87.9 (n)
  • 84.79 (a)
TRMT5 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRMT5 36
  • 88.25 (n)
  • 83.96 (a)
TRMT5 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trmt5 36
  • 81.7 (n)
  • 76.55 (a)
Trmt5 16
Trmt5 37
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRMT5 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trmt5 36
  • 82.05 (n)
  • 81 (a)
chicken
(Gallus gallus)
Aves TRMT5 36
  • 68.69 (n)
  • 64.65 (a)
TRMT5 37
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRMT5 37
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trmt5 36
  • 65.45 (n)
  • 62.5 (a)
zebrafish
(Danio rerio)
Actinopterygii trmt5 36
  • 59.16 (n)
  • 60.66 (a)
trmt5 37
  • 55 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006124 36
  • 49.49 (n)
  • 41.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32281 36
  • 50.17 (n)
  • 46.45 (a)
CG32281 37
  • 42 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C53A5.17 36
  • 47.55 (n)
  • 35.91 (a)
C53A5.17 37
  • 31 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL033W 36
  • 46.82 (n)
  • 42.49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM5 36
  • 50.89 (n)
  • 43.8 (a)
TRM5 37
  • 33 (a)
OneToOne
TRM5 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E12761g 36
  • 48.83 (n)
  • 41 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G56120 36
  • 51.18 (n)
  • 39.65 (a)
rice
(Oryza sativa)
Liliopsida Os02g0606301 36
  • 55.98 (n)
  • 46.56 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09311 36
  • 48.01 (n)
  • 39.44 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes trm5 36
  • 52.9 (n)
  • 43.64 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 40 (a)
OneToOne
Species with no ortholog for TRMT5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRMT5 Gene

ENSEMBL:
Gene Tree for TRMT5 (if available)
TreeFam:
Gene Tree for TRMT5 (if available)

Paralogs for TRMT5 Gene

No data available for Paralogs for TRMT5 Gene

Variants for TRMT5 Gene

Sequence variations from dbSNP and Humsavar for TRMT5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs913485 -- 60,974,470(-) tgctc(A/G)tttgt utr-variant-3-prime
rs1129311 -- 60,975,178(-) GATCC(A/C/G)CCTCT reference, synonymous-codon
rs1141777 -- 60,972,550(-) GAGGC(A/G)AGAAC utr-variant-3-prime
rs1887742 -- 60,973,465(-) cctta(A/C)gataa utr-variant-3-prime
rs1958281 -- 60,971,588(-) TATAG(C/T)GGCTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TRMT5 Gene

Variant ID Type Subtype PubMed ID
esv2748755 CNV Deletion 23290073

Relevant External Links for TRMT5 Gene

HapMap Linkage Disequilibrium report
TRMT5

Disorders for TRMT5 Gene

Relevant External Links for TRMT5

Genetic Association Database (GAD)
TRMT5
Human Genome Epidemiology (HuGE) Navigator
TRMT5
genes like me logo Genes that share disorders with TRMT5: view

No data available for UniProtKB/Swiss-Prot for TRMT5 Gene

Publications for TRMT5 Gene

  1. Isolation and characterization of the human tRNA-(N1G37) methyltransferase (TRM5) and comparison to the Escherichia coli TrmD protein. (PMID: 15248782) Brule H. … Holmes W.M. (Biochemistry 2004) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Identification of host proteins required for HIV infection through a functional genomic screen. (PMID: 18187620) Brass A.L. … Elledge S.J. (Science 2008) 3

Products for TRMT5 Gene

Sources for TRMT5 Gene

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