TRMT44 Gene
protein-coding GIFtS : 41
GCID: GC04 P008439
tRNA methyltransferase 44 homolog (S. cerevisiae) (Previous names: chromosome 4 open reading frame 23, methyltransferase like... ) (Previous symbols: C4orf23, METTL19 )
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Aliasesfor TRMT44 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases TRNA Methyltransferase 44 Homolog (S. Cerevisiae) 1 2 FLJ357251 C4orf231 2 3 Chromosome 4 Open Reading Frame 231 METTL191 2 3 Probable TRNA (Uracil-O(2)-)-Methyltransferase2 TRM441 2 EC 2.1.1.2113 Methyltransferase Like 191 2 EC 2.1.18 Methyltransferase-Like Protein 192 3
Export aliases for TRMT44 gene to outside databases
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Summariesfor TRMT44 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for TRMT44 : The protein encoded by this gene is a putative tRNA methyltransferase found in the cytoplasm. Defects in this gene may be a cause of partial epilepsy with pericentral spikes (PEPS), but that has not been proven definitively. (provided by RefSeq, May 2012) UniProtKB/Swiss-Prot: TRM44_HUMAN, Q8IYL2 Function : Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase (By similarity)
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Genomic Viewsfor TRMT44 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000004.11 NC_018915.1 NT_006051.18 Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for TRMT44 Other transcription factors Search SABiosciences Chromatin IP Primers for TRMT44 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TRMT44
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 4p16.1 Ensembl cytogenetic band: 4p16.1 HGNC cytogenetic band: 4p16.1 TRMT44 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04P008439: view genomic region
(about GC identifiers )
Start:
8,437,867 bp from pter
End:
8,495,258 bp from pter
Size:
57,392 bases
Orientation:
plus strand
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Proteinsfor TRMT44 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TRM44_HUMAN, Q8IYL2 (See
protein sequence )Recommended Name: Probable tRNA (uracil-O(2)-)-methyltransferase Size : 757 amino acids; 84629 Da
Subcellular location : Cytoplasm (Probable)
Secondary accessions : Q8NA95Alternative splicing : 3 isoforms : Q8IYL2-1 Q8IYL2-2 Q8IYL2-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TRMT44: NX_Q8IYL2 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8IYL2 2 DME Specific Peptides for TRMT44 (Q8IYL2 ) TRMT44 Protein expression data from MOPED and PaxDb : --REFSEQ proteins: NP_689757.2 ENSEMBL proteins: ENSP00000424643 ENSP00000374387 ENSP00000434207 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005737 cytoplasm
IEA --
TRMT44 for ontologies About GeneDecksing TRMT44 Antibody Products: Assay Products for TRMT44:
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Protein
Domains / Familiesfor TRMT44 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TRMT44 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8IYL2 ProtoNet protein and cluster: Q8IYL2
UniProtKB/Swiss-Prot: TRM44_HUMAN, Q8IYL2 Similarity : Belongs to the TRM44 familySimilarity : Contains 1 C3H1-type zinc finger
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Functionfor TRMT44 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: TRM44_HUMAN, Q8IYL2 Function : Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase (By similarity)Catalytic activity : S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) = S-adenosyl-L-homocysteine +2'-O-methyluridine(44) in tRNA(Ser) Enzyme Numbers (IUBMB): EC 2.1.1 2 EC 2.1.1.211 1
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TRMT44 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TRMT44 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript Custom all cDNA clones Services for TRMT44 Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRMT44 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TRMT44
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT44
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003676 nucleic acid binding
IEA -- GO:0008168 methyltransferase activity
IEA -- GO:0008270 zinc ion binding
IEA --
TRMT44 for ontologies About GeneDecksing
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Pathways & Interactionsfor TRMT44 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRMT44 Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0008033 tRNA processing
IEA --
TRMT44 for ontologies About GeneDecksing
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Drugs & Compoundsfor TRMT44 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TRMT44 Search CenterWatch for drugs/clinical trials and news about TRMT44 / TRM44
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Transcriptsfor TRMT44 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TRMT44 gene (3 alternative transcripts): NM_152544.2 NM_001031742.1 NM_024950.1 Unigene Clusters for TRMT44:
TRNA methyltransferase 44 homolog (S. cerevisiae) Hs.566191 [show with all ESTs ] , Hs.734761 [show with all ESTs ] Unigene Representative Sequences: NM_152544 , AK022953 9 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000532937 ENST00000513449 (uc003glf.1 ) ENST00000528167 ENST00000389737 ENST00000504134 ENST00000532477 ENST00000531038 ENST00000511149 ENST00000511366 (uc003glg.2 uc003glh.1 uc003gli.1 )Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TRMT44 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TRMT44 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript Custom all cDNA clones Services for TRMT44 DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRMT44 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TRMT44
Additional cDNA sequence: AK022953.1
7 DOTS entries : DT.40108101 DT.100019704
DT.309383 DT.434305 DT.92036858 DT.95121794 DT.309385 24/70 AceView cDNA sequences (see all 70 ):
BM553149 BE048583 AK093044 NM_152544 CB306073 AW449191 BC035655 AA235671 AX747880 CR604280 BM913327 BG751175 AJ707605 AI744550 AW959379 F13275 BE856998 BM810950 AK096417 U90910 W65353 AW779547 BX371487 CD655064 GeneLoc Exon Structure 5 Alternative Splicing Database (ASD) splice patterns (SP) for TRMT44 About this scheme ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c SP1 :   -         -                           SP2 :                     -     -   -   -         SP3 :           -                           SP4 :                             -         SP5 :                                    
ECgene alternative splicing isoforms for TRMT44
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Expression for TRMT44 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section See probesets specificity/sensitivity at GeneAnnot CGAP TAG: -- TRMT44 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Definitive endoderm-like cells (A scalable, suspensi... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
Genevestigator expression for TRMT44 SOURCE GeneReport for Unigene clusters: Hs.566191 Hs.734761 SABiosciences Custom PCR Arrays for TRMT44 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TRMT44Browse OriGene validated miRNA SYBR primer pairs Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat TRMT44 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TRMT44 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TRMT44 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT44
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Orthologsfor TRMT44 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for TRMT44 gene from 7/24 species (see all 24 ) About this table
ENSEMBL Gene Tree for TRMT44 (if available)TreeFam Gene Tree for TRMT44 (if available)
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Paralogsfor TRMT44 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor TRMT44 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Human Gene Mutation Database (HGMD) : TRMT44 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TRMT44
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Disorders
/ Diseasesfor TRMT44 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
TRMT44 for disorders About GeneDecksing
OMIM gene information: 614309
OMIM disorders : --3 diseases for TRMT44 : About MalaCards epilepsy syndrome homocysteine leukemia Export disorders for TRMT44 gene to outside databases
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Publicationsfor TRMT44 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TRMT44 gene integrated from 9 sources : (articles sorted by number of sources associating them with TRMT44) Utopia : connect your pdf to the dynamic world of online information
Q8IYL2 is a candidate gene for the familial epilepsy syndrome of Partial Epilepsy with Pericentral Spikes (PEPS). (PubMed id 21658913) 1 , 2 , 3 Leschziner G.D....Johnson M.R. (2011) DUF1613 is a novel family of eucaryotic AdoMet-dependent methyltransferases. (PubMed id 16861910) 1 , 2 Knizewski L. and Ginalski K. (2006) Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621) 1 , 2 Hillier L.W....Wilson R.K. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674) 1 Altun M....Kessler B.M. (2011) Association between SNP-genotype and chronic lymphocy tic leukemia outcome in a randomized chemotherapy trial. (PubMed id 21659360) 1 Wade R....Houlston R.S. (2011) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548) 1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for TRMT44 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TRMT44 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TRMT44 gene
(According to HUGE )
About This Section --
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Specialized Databases showing TRMT44 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for TRMT44 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for TRMT44 gene: Search GeneIP for patents involving TRMT44 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TRMT44 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies Browse OriGene shRNA RFPs OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TRMT44 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TRMT44 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TRMT44 OriGene 3'-UTR Clone for TRMT44 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TRMT44 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TRMT44 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TRMT44 OriGene Custom Protein Services for TRMT44 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRMT44 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TRMT44 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TRMT44 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TRMT44 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TRMT44 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TRMT44
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TRMT44 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT44
ThermoFisher Antibodies for TRMT44
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TRMT44
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Aliases for TRMT44
Databases for TRMT44
Disorders / Diseases for TRMT44
Domains / Families for TRMT44
Drugs / Compounds for TRMT44
Expression for TRMT44
Function for TRMT44
Genomic Views for TRMT44
Intellectual Property for TRMT44
Orthologs for TRMT44
Paralogs for TRMT44
Pathways / Interactions for TRMT44
Products for TRMT44
Proteins for TRMT44
Publications for TRMT44
Search Box for TRMT44
Summaries for TRMT44
Transcripts for TRMT44
Variants for TRMT44
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