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Aliases for TRMT44 Gene

Aliases for TRMT44 Gene

  • TRNA Methyltransferase 44 Homolog (S. Cerevisiae) 2 3 2 5
  • Methyltransferase-Like Protein 19 3 4
  • Methyltransferase Like 19 2 3
  • C4orf23 3 4
  • METTL19 3 4
  • Chromosome 4 Open Reading Frame 23 2
  • EC 4
  • EC 2.1.1 63
  • TRM44 3

External Ids for TRMT44 Gene

Previous HGNC Symbols for TRMT44 Gene

  • C4orf23
  • METTL19

Summaries for TRMT44 Gene

Entrez Gene Summary for TRMT44 Gene

  • The protein encoded by this gene is a putative tRNA methyltransferase found in the cytoplasm. Defects in this gene may be a cause of partial epilepsy with pericentral spikes (PEPS), but that has not been proven definitively. [provided by RefSeq, May 2012]

GeneCards Summary for TRMT44 Gene

TRMT44 (TRNA Methyltransferase 44 Homolog (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. GO annotations related to this gene include methyltransferase activity.

UniProtKB/Swiss-Prot for TRMT44 Gene

  • Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT44 Gene

Genomics for TRMT44 Gene

Regulatory Elements for TRMT44 Gene

Enhancers for TRMT44 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRMT44 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRMT44 Gene

8,436,140 bp from pter
8,516,547 bp from pter
80,408 bases
Plus strand

Genomic View for TRMT44 Gene

Genes around TRMT44 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRMT44 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRMT44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT44 Gene

Proteins for TRMT44 Gene

  • Protein details for TRMT44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable tRNA (uracil-O(2)-)-methyltransferase
    Protein Accession:
    Secondary Accessions:
    • Q8NA95

    Protein attributes for TRMT44 Gene

    757 amino acids
    Molecular mass:
    84629 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRMT44 Gene


neXtProt entry for TRMT44 Gene

Proteomics data for TRMT44 Gene at MOPED

Selected DME Specific Peptides for TRMT44 Gene

Post-translational modifications for TRMT44 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRMT44 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for TRMT44 Gene

Gene Families for TRMT44 Gene

Protein Domains for TRMT44 Gene

Suggested Antigen Peptide Sequences for TRMT44 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRM44 family.
  • Contains 1 C3H1-type zinc finger.
  • Belongs to the TRM44 family.
  • Contains 1 C3H1-type zinc finger.
genes like me logo Genes that share domains with TRMT44: view

Function for TRMT44 Gene

Molecular function for TRMT44 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) = S-adenosyl-L-homocysteine + 2-O-methyluridine(44) in tRNA(Ser).
UniProtKB/Swiss-Prot Function:
Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.

Enzyme Numbers (IUBMB) for TRMT44 Gene

Gene Ontology (GO) - Molecular Function for TRMT44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016300 tRNA (uracil) methyltransferase activity IBA --
genes like me logo Genes that share ontologies with TRMT44: view

Phenotypes for TRMT44 Gene

genes like me logo Genes that share phenotypes with TRMT44: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRMT44 Gene

Localization for TRMT44 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRMT44 Gene


Subcellular locations from

Jensen Localization Image for TRMT44 Gene COMPARTMENTS Subcellular localization image for TRMT44 gene
Compartment Confidence
nucleus 3
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TRMT44 Gene

Pathways & Interactions for TRMT44 Gene

genes like me logo Genes that share pathways with TRMT44: view

Pathways by source for TRMT44 Gene

Interacting Proteins for TRMT44 Gene

Gene Ontology (GO) - Biological Process for TRMT44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030488 tRNA methylation IBA --
genes like me logo Genes that share ontologies with TRMT44: view

No data available for SIGNOR curated interactions for TRMT44 Gene

Drugs & Compounds for TRMT44 Gene

(2) Drugs for TRMT44 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0
genes like me logo Genes that share compounds with TRMT44: view

Transcripts for TRMT44 Gene

Unigene Clusters for TRMT44 Gene

TRNA methyltransferase 44 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT44 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c
SP1: - -
SP2: - - - -
SP3: -
SP4: -

Relevant External Links for TRMT44 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRMT44 Gene

mRNA expression in normal human tissues for TRMT44 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRMT44 Gene

This gene is overexpressed in Platelet (68.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRMT44 Gene

SOURCE GeneReport for Unigene cluster for TRMT44 Gene Hs.566191

genes like me logo Genes that share expression patterns with TRMT44: view

Protein tissue co-expression partners for TRMT44 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRMT44 Gene

Orthologs for TRMT44 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRMT44 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRMT44 35
  • 77.82 (n)
  • 73.79 (a)
TRMT44 36
  • 71 (a)
(Canis familiaris)
Mammalia TRMT44 35
  • 77.49 (n)
  • 71.04 (a)
TRMT44 36
  • 75 (a)
(Mus musculus)
Mammalia Trmt44 35
  • 73.15 (n)
  • 70.28 (a)
Trmt44 16
Trmt44 36
  • 70 (a)
(Pan troglodytes)
Mammalia TRMT44 35
  • 95.76 (n)
  • 94.77 (a)
TRMT44 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Trmt44 35
  • 73.86 (n)
  • 71.86 (a)
(Monodelphis domestica)
Mammalia TRMT44 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia TRMT44 36
  • 69 (a)
(Gallus gallus)
Aves METTL19 35
  • 64.79 (n)
  • 62.61 (a)
TRMT44 36
  • 61 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 72 (a)
-- 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3599 35
trmt44 35
  • 66.88 (n)
  • 66.56 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398534 35
(Danio rerio)
Actinopterygii trmt44 35
  • 58.66 (n)
  • 57.42 (a)
trmt44 36
  • 52 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006663 35
  • 53.21 (n)
  • 48.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9386 35
  • 50.32 (n)
  • 45.96 (a)
CG9386 36
  • 35 (a)
(Caenorhabditis elegans)
Secernentea C23G10.7 36
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM44 36
  • 21 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8390 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
Species with no ortholog for TRMT44:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRMT44 Gene

Gene Tree for TRMT44 (if available)
Gene Tree for TRMT44 (if available)

Paralogs for TRMT44 Gene

No data available for Paralogs for TRMT44 Gene

Variants for TRMT44 Gene

Sequence variations from dbSNP and Humsavar for TRMT44 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1880024 - 8,452,912(-) TAGTC(C/T)CCTCT nc-transcript-variant, reference, missense
rs73211375 - 8,449,832(+) CCATT(A/T)TGAAG nc-transcript-variant, reference, missense
rs34873641 - 8,465,430(-) TCCAA(C/T)GAAGT nc-transcript-variant, reference, missense
rs150441746 - 8,468,341(+) GAATG(C/G)GGGAG nc-transcript-variant, reference, missense
rs868105 -- 8,499,303(+) GCCGT(G/T)TCTCT intron-variant

Variation tolerance for TRMT44 Gene

Residual Variation Intolerance Score: 94.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.70; 57.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRMT44 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TRMT44 Gene

Disorders for TRMT44 Gene

Relevant External Links for TRMT44

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TRMT44 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRMT44 Gene

Publications for TRMT44 Gene

  1. Q8IYL2 is a candidate gene for the familial epilepsy syndrome of partial epilepsy with pericentral spikes (PEPS). (PMID: 21658913) Leschziner G.D. … Johnson M.R. (Epilepsy Res. 2011) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Association between single nucleotide polymorphism-genotype and outcome of patients with chronic lymphocytic leukemia in a randomized chemotherapy trial. (PMID: 21659360) Wade R. … Houlston R.S. (Haematologica 2011) 3
  4. DUF1613 is a novel family of eucaryotic AdoMet-dependent methyltransferases. (PMID: 16861910) Knizewski L. … Ginalski K. (Cell Cycle 2006) 3
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3

Products for TRMT44 Gene

Sources for TRMT44 Gene