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Aliases for TRMT44 Gene

Aliases for TRMT44 Gene

  • TRNA Methyltransferase 44 Homolog (S. Cerevisiae) 2 3 2
  • METTL19 3 4 6
  • Methyltransferase-Like Protein 19 3 4
  • Methyltransferase Like 19 2 3
  • C4orf23 3 4
  • Probable TRNA (Uracil-O(2)-)-Methyltransferase 3
  • Chromosome 4 Open Reading Frame 23 2
  • EC 2.1.1.211 4
  • EC 2.1.1 64
  • TRM44 3

External Ids for TRMT44 Gene

Previous Symbols for TRMT44 Gene

  • C4orf23
  • METTL19

Summaries for TRMT44 Gene

Entrez Gene Summary for TRMT44 Gene

  • The protein encoded by this gene is a putative tRNA methyltransferase found in the cytoplasm. Defects in this gene may be a cause of partial epilepsy with pericentral spikes (PEPS), but that has not been proven definitively. [provided by RefSeq, May 2012]

GeneCards Summary for TRMT44 Gene

TRMT44 (TRNA Methyltransferase 44 Homolog (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity.

UniProtKB/Swiss-Prot for TRMT44 Gene

  • Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT44 Gene

Genomics for TRMT44 Gene

Genomic Location for TRMT44 Gene

Start:
8,436,140 bp from pter
End:
8,509,653 bp from pter
Size:
73,514 bases
Orientation:
Plus strand

Genomic View for TRMT44 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRMT44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT44 Gene

No data available for Regulatory Elements for TRMT44 Gene

Proteins for TRMT44 Gene

  • Protein details for TRMT44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYL2-TRM44_HUMAN
    Recommended name:
    Probable tRNA (uracil-O(2)-)-methyltransferase
    Protein Accession:
    Q8IYL2
    Secondary Accessions:
    • Q8NA95

    Protein attributes for TRMT44 Gene

    Size:
    757 amino acids
    Molecular mass:
    84629 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRMT44 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRMT44 Gene

Proteomics data for TRMT44 Gene at MOPED

Selected DME Specific Peptides for TRMT44 Gene

Post-translational modifications for TRMT44 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRMT44 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for TRMT44 Gene

Protein Domains for TRMT44 Gene

UniProtKB/Swiss-Prot:

TRM44_HUMAN
Family:
  • Belongs to the TRM44 family.:
    • Q8IYL2
Similarity:
  • Contains 1 C3H1-type zinc finger.:
    • Q8IYL2
genes like me logo Genes that share domains with TRMT44: view

No data available for Gene Families for TRMT44 Gene

Function for TRMT44 Gene

Molecular function for TRMT44 Gene

UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) = S-adenosyl-L-homocysteine + 2-O-methyluridine(44) in tRNA(Ser)
UniProtKB/Swiss-Prot Function: Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.

Enzyme Numbers (IUBMB) for TRMT44 Gene

Gene Ontology (GO) - Molecular Function for TRMT44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRMT44: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TRMT44 Gene

Localization for TRMT44 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRMT44 Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for TRMT44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TRMT44: view

Pathways for TRMT44 Gene

SuperPathways for TRMT44 Gene

No Data Available

Interacting Proteins for TRMT44 Gene

Gene Ontology (GO) - Biological Process for TRMT44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008033 tRNA processing IEA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with TRMT44: view

No data available for Pathways by source for TRMT44 Gene

Transcripts for TRMT44 Gene

Unigene Clusters for TRMT44 Gene

TRNA methyltransferase 44 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT44 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c
SP1: - -
SP2: - - - -
SP3: -
SP4: -
SP5:

Relevant External Links for TRMT44 Gene

GeneLoc Exon Structure for
TRMT44
ECgene alternative splicing isoforms for
TRMT44

Expression for TRMT44 Gene

mRNA expression in normal human tissues for TRMT44 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TRMT44 Gene

SOURCE GeneReport for Unigene cluster for TRMT44 Gene Hs.566191

genes like me logo Genes that share expressions with TRMT44: view

Orthologs for TRMT44 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRMT44 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRMT44 36
  • 95.76 (n)
  • 94.77 (a)
TRMT44 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRMT44 36
  • 77.82 (n)
  • 73.79 (a)
TRMT44 37
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRMT44 36
  • 77.49 (n)
  • 71.04 (a)
TRMT44 37
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trmt44 36
  • 73.15 (n)
  • 70.28 (a)
Trmt44 16
Trmt44 37
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRMT44 37
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRMT44 37
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trmt44 36
  • 73.86 (n)
  • 71.86 (a)
chicken
(Gallus gallus)
Aves METTL19 36
  • 64.79 (n)
  • 62.61 (a)
TRMT44 37
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 72 (a)
OneToMany
-- 37
  • 56 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia LOC398534 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3599 36
trmt44 36
  • 66.88 (n)
  • 66.56 (a)
zebrafish
(Danio rerio)
Actinopterygii trmt44 36
  • 58.66 (n)
  • 57.42 (a)
trmt44 37
  • 52 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006663 36
  • 53.21 (n)
  • 48.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9386 36
  • 50.32 (n)
  • 45.96 (a)
CG9386 37
  • 35 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C23G10.7 37
  • 28 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM44 37
  • 21 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8390 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 49 (a)
OneToOne
Species with no ortholog for TRMT44:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRMT44 Gene

ENSEMBL:
Gene Tree for TRMT44 (if available)
TreeFam:
Gene Tree for TRMT44 (if available)

Paralogs for TRMT44 Gene

No data available for Paralogs for TRMT44 Gene

Variants for TRMT44 Gene

Sequence variations from dbSNP and Humsavar for TRMT44 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs2972 -- 8,493,400(-) gattg(G/T)tcggg intron-variant
rs868105 -- 8,499,303(+) GCCGT(G/T)TCTCT intron-variant
rs871363 -- 8,479,532(-) TTACC(A/G)TTGCG intron-variant
rs871364 -- 8,479,409(-) catga(A/G)cgcgg intron-variant
rs871768 -- 8,453,211(-) GGGCC(C/T)GGGGA intron-variant

Relevant External Links for TRMT44 Gene

HapMap Linkage Disequilibrium report
TRMT44
Human Gene Mutation Database (HGMD)
TRMT44

No data available for Structural Variations from Database of Genomic Variants (DGV) for TRMT44 Gene

Disorders for TRMT44 Gene

No disorders were found for TRMT44 Gene.

No data available for UniProtKB/Swiss-Prot for TRMT44 Gene

Publications for TRMT44 Gene

  1. Q8IYL2 is a candidate gene for the familial epilepsy syndrome of partial epilepsy with pericentral spikes (PEPS). (PMID: 21658913) Leschziner G.D. … Johnson M.R. (Epilepsy Res. 2011) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. DUF1613 is a novel family of eucaryotic AdoMet-dependent methyltransferases. (PMID: 16861910) Knizewski L. … Ginalski K. (Cell Cycle 2006) 3 4

Products for TRMT44 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TRMT44
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TRMT44
    • Block miRNA regulation of TRMT44 using miScript Target Protectors

    Sources for TRMT44 Gene

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