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TRMT2A Gene

protein-coding   GIFtS: 52
GCID: GC22M020099

TRNA Methyltransferase 2 Homolog A (S. Cerevisiae)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TRNA Methyltransferase 2 Homolog A (S. Cerevisiae)1 2     TRM2 TRNA Methyltransferase 2 Homolog A2
HTF9C2 3 5     TRNA (Uracil-5-)-Methyltransferase Homolog A2
HpaII Tiny Fragments Locus 9c Protein2 3     EC 2.1.1.-3
HpaII Tiny Fragments Locus 9C1     

External Ids:    HGNC: 249741   Entrez Gene: 270372   Ensembl: ENSG000000998997   OMIM: 6111515   UniProtKB: Q8IZ693   

Export aliases for TRMT2A gene to outside databases

Previous GC identifers: GC22M018479 GC22M003720


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRMT2A Gene:
The protein encoded by this gene is of unknown function. However, it is orthologous to the mouse Trmt2a gene and
contains an RNA methyltransferase domain. Expression of this gene varies during the cell cycle, with aberrant
expression being a possible biomarker in certain breast cancers. Several transcript variants encoding two
different isoforms have been found for this gene. (provided by RefSeq, Apr 2012)

GeneCards Summary for TRMT2A Gene:
TRMT2A (tRNA methyltransferase 2 homolog A (S. cerevisiae)) is a protein-coding gene. Diseases associated with TRMT2A include breast cancer, and breast and colorectal cancer. GO annotations related to this gene include RNA binding and RNA methyltransferase activity. An important paralog of this gene is TRMT2B.

UniProtKB/Swiss-Prot: TRM2A_HUMAN, Q8IZ69
Function: May be involved in nucleic acid metabolism and/or modifications




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TRMT2A gene promoter:
         SRF   CREB   Spz1   Pax-5   deltaCREB   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRMT2A promoter sequence
   Search Chromatin IP Primers for TRMT2A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRMT2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.21

TRMT2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRMT2A gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M020099:  view genomic region     (about GC identifiers)

Start:
20,099,389 bp from pter      End:
20,104,915 bp from pter
Size:
5,527 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TRM2A_HUMAN, Q8IZ69 (See protein sequence)
Recommended Name: tRNA (uracil-5-)-methyltransferase homolog A  
Size: 625 amino acids; 68726 Da
Secondary accessions: D3DX25 Q32P57 Q96ME6 Q9H732
Alternative splicing: 2 isoforms:  Q8IZ69-1   Q8IZ69-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRMT2A: NX_Q8IZ69

Explore proteomics data for TRMT2A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys187, Lys242, Lys290, Lys314, Lys346
  • Modification sites at PhosphoSitePlus

  • See TRMT2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001244923.1  NP_073564.3  NP_892029.2  

    ENSEMBL proteins: 
     ENSP00000252136   ENSP00000385807   ENSP00000397744   ENSP00000384968   ENSP00000395738  
     ENSP00000392261   ENSP00000393911  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR010280 U5_MeTrfase_fam
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q8IZ69

    ProtoNet protein and cluster: Q8IZ69

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB010280 (Uracil-5)-methyltransferase


    UniProtKB/Swiss-Prot: TRM2A_HUMAN, Q8IZ69
    Similarity: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase
    family
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    TRMT2A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRM2A_HUMAN, Q8IZ69
    Function: May be involved in nucleic acid metabolism and/or modifications

         Enzyme Number (IUBMB): EC 2.1.1.-1

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0004719protein-L-isoaspartate (D-aspartate) O-methyltransferase activity ----
    GO:0008168methyltransferase activity ----
         
    TRMT2A for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for TRMT2A:
     Decreased homologous recombina  G0/1 arrest  Increased G1 DNA content  Increased cell number in G1, a 

         1 MGI phenotypic allele for Trmt2a (no phenotypes)

    TRMT2A for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRMT2A
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRMT2A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRMT2A

    miRNA
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    miRTarBase miRNAs that target TRMT2A:
    hsa-mir-26b-5p (MIRT029799), hsa-mir-744-5p (MIRT037605), hsa-mir-193b-3p (MIRT041422), hsa-mir-125a-5p (MIRT045766)

    Block miRNA regulation of human, mouse, rat TRMT2A using miScript Target Protectors
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    Predesigned siRNA for gene silencing in human, mouse, rat TRMT2A

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    GenScript: all cDNA clones in your preferred vector (see all 2): TRMT2A (NM_182984)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT2A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRMT2A
    Interactions:

        Search GeneGlobe Interaction Network for TRMT2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for TRMT2A (Q8IZ692, 3 ENSP000002521364) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-8271619 I2D: score=2 
    SMN2Q166372, 3MINT-8271619 I2D: score=2 
    AIMP2Q131552, 3MINT-8259018 I2D: score=2 
    ANXA7P200732, 3MINT-8248845 I2D: score=2 
    ATP1B1P050262, 3MINT-8249179 I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006396RNA processing IEA--
    GO:0006400tRNA modification ----
    GO:0006464cellular protein modification process ----
    GO:0008152metabolic process ----
    GO:0031167rRNA methylation ----

    TRMT2A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRMT2A (TRM2A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TRMT2A gene (3 alternative transcripts): 
    NM_001257994.1  NM_022727.5  NM_182984.4  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000252136(uc002zrl.1) ENST00000403707(uc002zrk.1) ENST00000480339
    ENST00000444845 ENST00000404751(uc011ahk.2) ENST00000487668 ENST00000439169
    ENST00000487378 ENST00000444256 ENST00000494820 ENST00000492988 ENST00000471040
    ENST00000488335 ENST00000463710 ENST00000459644 ENST00000468917 ENST00000480460
    ENST00000494641
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TRMT2A
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    GenScript: all cDNA clones in your preferred vector (see all 2): TRMT2A (NM_182984)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRMT2A
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      QuantiTect SYBR Green Assays in human, mouse, rat TRMT2A
      QuantiFast Probe-based Assays in human, mouse, rat TRMT2A

    Selected AceView cDNA sequences (see all 262):

    AI356161 CB991807 CR617494 CR456354 AI360696 BX368596 CB997893 CA440188 
    BQ218428 BU500211 BX483018 BF434314 AI337338 CA440649 CR595584 BX387340 
    CD171682 BP382598 BM452039 BQ434796 CR608558 AW873997 AW006311 AI479723 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TRMT2A (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^
    SP1:                          -     -     -                                   -           -     -                             -                                 
    SP2:                                                                          -           -     -                             -                                 
    SP3:                                                                          -           -     -                             -                                 
    SP4:                                                                                      -     -                             -                                 
    SP5:                                                                                                                                                            

    ExUns: 13a · 13b ^ 14 ^ 15a · 15b · 15c · 15d · 15e
    SP1:  -                 -                           
    SP2:  -                                             
    SP3:  -                 -                           
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for TRMT2A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRMT2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTGCTGGC
    TRMT2A Expression
    About this image


    TRMT2A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Midgut
     
     Eye (Sensory Organs)
             Retina
     
     Spleen (Hematopoietic System)
    TRMT2A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRMT2A Protein Expression
        Custom PCR Arrays for TRMT2A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT2A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TRMT2A gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trmt2a1 , 5 TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)5
    TRM2 tRNA methyltransferase 2A1
    82.82(n)1
    86.43(a)1
      16 (11.31 cM)5
    155471  NM_001081000.21  NP_001074469.11 
     182486795 
    chicken
    (Gallus gallus)
    Aves TRMT2A1 tRNA methyltransferase 2 homolog A (S. cerevisiae) 68.34(n)
    71.8(a)
      416786  XM_415080.4  XP_415080.2 
    lizard
    (Anolis carolinensis)
    Reptilia TRMT2A6
    tRNA methyltransferase 2 homolog A (S. cerevisiae)...
    56(a)
    1 ↔ 1
    GL343364.1(1007484-1051176)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.84342 Xenopus laevis transcribed sequence with moderate similarity more 70.84(n)    CF288992.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa10b062 wufa10b06 73.6(n)   334936  BC045367.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG38081 CG3808 49.35(n)
    40.5(a)
      40074  NM_140826.2  NP_649083.2 
    worm
    (Caenorhabditis elegans)
    Secernentea H24K24.41 H24K24.4 44.31(n)
    32.94(a)
      186775  NM_070952.4  NP_503353.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TRM2(YKR056W)4 tRNA methyltransferase, 5-methylates the uridine residue more   --   11(549448-551367) 853930  NP_012982.2 


    ENSEMBL Gene Tree for TRMT2A (if available)
    TreeFam Gene Tree for TRMT2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRMT2A gene
    TRMT2B2  
    1 SIMAP similar gene for TRMT2A using alignment to 5 protein entries:     TRM2A_HUMAN (see all proteins):
    TRMT2B

    TRMT2A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRMT2A (see all 142)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0354824
    A breast cancer sample4--see VAR_0354822 P S mis40--------
    rs1139589951,2
    C,F--20099941(+) GCCCCT/AAGCAG 3 -- ut312Minor allele frequency- A:0.07CSA WA 120
    rs1498615781,2
    F--20100104(+) AAGGTC/GCCAGT 5 G syn1 ut311Minor allele frequency- G:0.00NA 4546
    rs1458491841,2
    F--20100127(+) GTTATC/TTGGGG 5 N D mis1 ut311Minor allele frequency- T:0.00NA 4546
    rs1907939101,2
    C--20100133(+) TGGGGA/GTCCTG 5 P S mis1 ut310--------
    rs4470171,2,,4
    C,F,A,H--20100158(+) GGAGGG/CCTGTG 5 /S /R mis1 ut31 ese314Minor allele frequency- C:0.05MN EA NA NS EU 6693
    rs1476961621,2
    C,F--20100200(+) TCCACC/TCTCTC 5 R syn1 ut311Minor allele frequency- T:0.01NA 4548
    rs1996833381,2
    --20100209(+) TCAAAC/TAGGAT 5 L syn1 ut310--------
    rs1465517481,2
    F--20100239(+) GTCTGC/TGGGAA 5 P syn1 ut311Minor allele frequency- T:0.00NA 4548
    rs1413959321,2
    C,F--20100269(+) TTGACC/TGGCCG 5 P syn1 ut312Minor allele frequency- T:0.00NA EU 5865

    HapMap Linkage Disequilibrium report for TRMT2A (20099389 - 20104915 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TRMT2A (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv435744CNV Deletion17901297
    dgv4857n71CNV Loss21882294
    dgv4860n71CNV Loss21882294
    nsv834133CNV Loss17160897
    nsv471183CNV Loss18288195
    nsv914327CNV Loss21882294
    dgv4859n71CNV Loss21882294
    dgv4858n71CNV Loss21882294
    nsv828939CNV Loss20364138
    nsv914347CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611151    OMIM disorders: --

    6 diseases for TRMT2A:    
    About MalaCards
    breast cancer    breast and colorectal cancer    pneumonia    schizophrenia
    malaria    colorectal cancer


    TRMT2A for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: TRMT2A (0 documents)

    Export disorders for TRMT2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRMT2A gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with TRMT2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. HTF9C gene of 22q11.21 region associates with schizophrenia having deficit-sustained attention. (PubMed id 18075473)1, 3, 9 Liu Y.L....Hwu H.G. (Psychiatr. Genet. 2007)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    5. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    6. Interactions with single-stranded and double-stranded DNA-binding factors and alternative promoter conformation upon transcriptional activation of the Htf9-a/RanBP1 and Htf9-c genes. (PubMed id 9417108)1, 3 Di Matteo G....Lavia P. (J. Biol. Chem. 1998)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)1 Stehling O.... Lill R. (Science 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27037 HGNC: 24974 AceView: HTF9C Ensembl:ENSG00000099899 euGenes: HUgn27037
    ECgene: TRMT2A H-InvDB: TRMT2A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRMT2A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TRMT2A gene:
    Search GeneIP for patents involving TRMT2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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