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Aliases for TRMT1L Gene

Aliases for TRMT1L Gene

  • TRNA Methyltransferase 1 Homolog (S. Cerevisiae)-Like 2 3
  • C1orf25 3 4 6
  • TRM1L 3 4 6
  • TRM1 TRNA Methyltransferase 1-Like 2 3
  • Chromosome 1 Open Reading Frame 25 2
  • TRMT1-Like Protein 3
  • TRM1-Like Protein 3
  • BG120K12.3 3
  • EC 2.1.1.- 4
  • TRM1-Like 2
  • MSTP070 3
  • MST070 3

External Ids for TRMT1L Gene

Previous HGNC Symbols for TRMT1L Gene

  • C1orf25

Summaries for TRMT1L Gene

Entrez Gene Summary for TRMT1L Gene

  • This gene encodes a protein that has some similarity to N2,N2-dimethylguanosine tRNA methyltransferase from other organisms. Studies of the mouse ortholog have shown that this protein plays a role in motor coordination and exploratory behavior, and it may also be involved in modulating postnatal neuronal functions. Alternatively spliced transcripts have been identified for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for TRMT1L Gene

TRMT1L (TRNA Methyltransferase 1 Homolog (S. Cerevisiae)-Like) is a Protein Coding gene. GO annotations related to this gene include tRNA binding and tRNA (guanine-N2-)-methyltransferase activity. An important paralog of this gene is TRMT1.

UniProtKB/Swiss-Prot for TRMT1L Gene

  • May play a role in motor coordination and exploratory behavior.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT1L Gene

Genomics for TRMT1L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRMT1L Gene

185,118,085 bp from pter
185,157,098 bp from pter
39,014 bases
Minus strand

Genomic View for TRMT1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRMT1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT1L Gene

No data available for Regulatory Elements for TRMT1L Gene

Proteins for TRMT1L Gene

  • Protein details for TRMT1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TRMT1-like protein
    Protein Accession:
    Secondary Accessions:
    • Q5TEN0
    • Q6ZMX0
    • Q8IWH5
    • Q8NC68
    • Q9BZQ1

    Protein attributes for TRMT1L Gene

    733 amino acids
    Molecular mass:
    81747 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH39738.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAQ13590.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI17851.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TRMT1L Gene


neXtProt entry for TRMT1L Gene

Proteomics data for TRMT1L Gene at MOPED

Post-translational modifications for TRMT1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRMT1L Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TRMT1L Gene

Domains for TRMT1L Gene

Protein Domains for TRMT1L Gene

Suggested Antigen Peptide Sequences for TRMT1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q7Z2T5
  • Contains 1 Trm1 methyltransferase domain.
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
  • Contains 1 C2H2-type zinc finger.
genes like me logo Genes that share domains with TRMT1L: view

No data available for Gene Families for TRMT1L Gene

Function for TRMT1L Gene

Molecular function for TRMT1L Gene

UniProtKB/Swiss-Prot Function:
May play a role in motor coordination and exploratory behavior.

Enzyme Numbers (IUBMB) for TRMT1L Gene

Gene Ontology (GO) - Molecular Function for TRMT1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IEA --
GO:0003723 RNA binding --
GO:0004809 tRNA (guanine-N2-)-methyltransferase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRMT1L: view

Phenotypes for TRMT1L Gene

genes like me logo Genes that share phenotypes with TRMT1L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRMT1L

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TRMT1L Gene

Localization for TRMT1L Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TRMT1L Gene

Pathways for TRMT1L Gene

SuperPathways for TRMT1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRMT1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008033 tRNA processing --
GO:0008344 adult locomotory behavior IEA --
GO:0030488 tRNA methylation IEA --
GO:0030534 adult behavior --
genes like me logo Genes that share ontologies with TRMT1L: view

No data available for Pathways by source for TRMT1L Gene

Transcripts for TRMT1L Gene

Unigene Clusters for TRMT1L Gene

TRNA methyltransferase 1 homolog (S. cerevisiae)-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRMT1L

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT1L Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c
SP1: - - - - -
SP2: - -
SP3: -
SP4: -

Relevant External Links for TRMT1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRMT1L Gene

mRNA expression in normal human tissues for TRMT1L Gene

Protein differential expression in normal tissues for TRMT1L Gene

This gene is overexpressed in Lung (36.4) and Colon muscle (12.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRMT1L Gene

SOURCE GeneReport for Unigene cluster for TRMT1L Gene Hs.107149

mRNA Expression by UniProt/SwissProt for TRMT1L Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with TRMT1L: view

Expression partners for TRMT1L Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TRMT1L Gene

Orthologs for TRMT1L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRMT1L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRMT1L 35
  • 92.87 (n)
  • 93.14 (a)
  • 92 (a)
(Canis familiaris)
Mammalia TRMT1L 35
  • 94.36 (n)
  • 94.54 (a)
  • 92 (a)
(Mus musculus)
Mammalia Trmt1l 35
  • 86.72 (n)
  • 88.32 (a)
Trmt1l 16
Trmt1l 36
  • 88 (a)
(Pan troglodytes)
Mammalia TRMT1L 35
  • 99.68 (n)
  • 99.45 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Trmt1l 35
  • 86.68 (n)
  • 88.11 (a)
(Monodelphis domestica)
Mammalia TRMT1L 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia TRMT1L 36
  • 75 (a)
(Gallus gallus)
Aves TRMT1L 35
  • 75.03 (n)
  • 72.29 (a)
  • 63 (a)
(Anolis carolinensis)
Reptilia TRMT1L 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15557 35
trmt1l 35
  • 64.88 (n)
  • 62.21 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33986 35
(Danio rerio)
Actinopterygii trmt1l 35
  • 62.9 (n)
  • 63.87 (a)
trmt1l 36
  • 56 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6388 36
  • 18 (a)
(Caenorhabditis elegans)
Secernentea trm-1 36
  • 17 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM1 36
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6910 36
  • 18 (a)
Species with no ortholog for TRMT1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRMT1L Gene

Gene Tree for TRMT1L (if available)
Gene Tree for TRMT1L (if available)

Paralogs for TRMT1L Gene

Paralogs for TRMT1L Gene

genes like me logo Genes that share paralogs with TRMT1L: view

Variants for TRMT1L Gene

Sequence variations from dbSNP and Humsavar for TRMT1L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs725847 -- 185,137,768(+) TACTT(C/G)TATGC missense, reference
rs726335 -- 185,136,872(-) GAATA(G/T)TACAC intron-variant
rs1053166 -- 185,119,565(-) GAACA(A/G)TGTTC utr-variant-3-prime
rs1208531 -- 185,139,328(+) TCAAA(C/T)ACTGA intron-variant
rs1322646 -- 185,141,735(+) GTGAA(A/G)AATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRMT1L Gene

Variant ID Type Subtype PubMed ID
nsv521613 CNV Loss 19592680
nsv872588 CNV Loss 21882294

Relevant External Links for TRMT1L Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRMT1L Gene

Disorders for TRMT1L Gene

No disorders were found for TRMT1L Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TRMT1L Gene

Publications for TRMT1L Gene

  1. Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus. (PMID: 11318611) Sood R. … Carpten J.D. (Genomics 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The mouse Trm1-like gene is expressed in neural tissues and plays a role in motor coordination and exploratory behaviour. (PMID: 17198746) Vauti F. … Arnold H.H. (Gene 2007) 2 3
  4. Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. (PMID: 17314511) Koch H.B. … Hermeking H. (Cell Cycle 2007) 3
  5. An integrated workflow for charting the human interaction proteome: insights into the PP2A system. (PMID: 19156129) Glatter T. … Gstaiger M. (Mol. Syst. Biol. 2009) 3

Products for TRMT1L Gene

Sources for TRMT1L Gene

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