TRMT13 Gene
protein-coding GIFtS : 39
GCID: GC01 P100599
tRNA methyltransferase 13 homolog (S. cerevisiae) (Previous name: coiled-coil domain containing 76 ) (Previous symbol: CCDC76 )
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Aliasesfor TRMT13 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases TRNA Methyltransferase 13 Homolog (S. Cerevisiae) 1 2 FLJ112191 CCDC761 2 3 TRNA [Gm4] Methyltransferase2 Coiled-Coil Domain Containing 761 2 TRNA Guanosine-2'-O-Methyltransferase TRM13 Homolog2 Coiled-Coil Domain-Containing Protein 762 3 EC 2.1.1.2253 FLJ102871
Export aliases for TRMT13 gene to outside databases
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Summariesfor TRMT13 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: TRM13_HUMAN, Q9NUP7 Function : tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) intRNA(His) (By similarity)
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Genomic Viewsfor TRMT13 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_032977.9 Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for TRMT13 Other transcription factors Search SABiosciences Chromatin IP Primers for TRMT13 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TRMT13
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1p21.2 Ensembl cytogenetic band: 1p21.2 HGNC cytogenetic band: 1p21.2 TRMT13 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P100599: view genomic region
(about GC identifiers )
Start:
100,598,706 bp from pter
End:
100,616,054 bp from pter
Size:
17,349 bases
Orientation:
plus strand
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Proteinsfor TRMT13 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TRM13_HUMAN, Q9NUP7 (See
protein sequence )Recommended Name: tRNA:m(4)X modification enzyme TRM13 homolog Size : 481 amino acids; 54247 Da
Secondary accessions : Q5VVL0 Q9NW65Alternative splicing : 2 isoforms : Q9NUP7-1 Q9NUP7-2 Explore the universe of human proteins at neXtProt for TRMT13: NX_Q9NUP7 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9NUP7 TRMT13 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_061956.2 ENSEMBL proteins: ENSP00000359162 ENSP00000359160 ENSP00000432616 ENSP00000359158 Human Recombinant Protein Products: TRMT13 Antibody Products: Assay Products for TRMT13:
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Protein
Domains / Familiesfor TRMT13 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TRMT13 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9NUP7 ProtoNet protein and cluster: Q9NUP7
UniProtKB/Swiss-Prot: TRM13_HUMAN, Q9NUP7 Similarity : Belongs to the TRM13 familySimilarity : Contains 1 CHHC-type zinc finger
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Functionfor TRMT13 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: TRM13_HUMAN, Q9NUP7 Function : tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) intRNA(His) (By similarity) Catalytic activity : S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridineCatalytic activity : S-adenosyl-L-methionine + cytidine(4) in tRNA(Pro) = S-adenosyl-L-homocysteine +2'-O-methylcytidine(4) in tRNA(Pro) Catalytic activity : S-adenosyl-L-methionine + cytidine(4) in tRNA(Gly)(GCC) = S-adenosyl-L-homocysteine +2'-O-methylcytidine(4) in tRNA(Gly)(GCC) Catalytic activity : S-adenosyl-L-methionine + adenosine(4) in tRNA(His) = S-adenosyl-L-homocysteine +2'-O-methyladenosine(4) in tRNA(His) Enzyme Number (IUBMB): EC 2.1.1.225 1
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TRMT13 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TRMT13OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript Custom all cDNA clones Services for TRMT13 Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRMT13 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TRMT13
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT13
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0008168 methyltransferase activity
IEA -- GO:0046872 metal ion binding
IEA --
TRMT13 for ontologies About GeneDecksing
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Pathways & Interactionsfor TRMT13 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRMT13 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for TRMT13 (ENSP00000359160 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0008033 tRNA processing
IEA --
TRMT13 for ontologies About GeneDecksing
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Drugs & Compoundsfor TRMT13 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TRMT13 Search CenterWatch for drugs/clinical trials and news about TRMT13 / TRM13
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Transcriptsfor TRMT13 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TRMT13 gene: NM_019083.2 Unigene Cluster for TRMT13:
TRNA methyltransferase 13 homolog (S. cerevisiae) Hs.729095 [show with all ESTs ] Unigene Representative Sequence: BC075811 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000370143 ENST00000370141 (uc001dsv.3 uc010ouf.2 uc009wea.3 )ENST00000482437 ENST00000370139 ENST00000493651 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TRMT13 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TRMT13OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript Custom all cDNA clones Services for TRMT13 DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRMT13 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TRMT13
Additional cDNA sequence: AK001149.1 AK002081.1 AK289404.1 AK294738.1 AK295828.1 AK298941.1 BC057226.1 BC075811.1
10 DOTS entries : DT.97820384 DT.212706
DT.307267 DT.97783625 DT.95263903 DT.100637842 DT.75188916 DT.91807726 DT.97817538 DT.91977190 24/85 AceView cDNA sequences (see all 85 ):
AI922312 AK002081 AA377262 CF272221 NM_019083 AK001149 AI922321 AA804788 AA292064 AA287558 BQ187089 BC075811 AA430376 BF514089 AA286765 AL040239 AA853970 AA476706 AA971154 AI028617 AU120776 AA292164 BU741542 AI276467 GeneLoc Exon Structure 5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TRMT13 (see all 9 ) About this scheme ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12 SP1 :                               -                 SP2 :                     -           -                 SP3 :                 -     -   -         -                 SP4 :                 -                               SP5 :                     -   -                        
ECgene alternative splicing isoforms for TRMT13
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Expression for TRMT13 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section See probesets specificity/sensitivity at GeneAnnot CGAP TAG: -- TRMT13 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Intermediate limb mesenchymal cells (ILM cells) (Primary Cell)Bone, Cartilage, Limb Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See TRMT13 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TRMT13 SOURCE GeneReport for Unigene cluster: Hs.729095 SABiosciences Custom PCR Arrays for TRMT13 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TRMT13Browse OriGene validated miRNA SYBR primer pairs Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat TRMT13 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TRMT13 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TRMT13 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT13
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Orthologsfor TRMT13 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for TRMT13 gene from 10/31 species (see all 31 ) About this table
ENSEMBL Gene Tree for TRMT13 (if available)TreeFam Gene Tree for TRMT13 (if available)
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Paralogsfor TRMT13 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor TRMT13 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for TRMT13 (100598706 - 100616054 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for TRMT13: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TRMT13
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Disorders
/ Diseasesfor TRMT13 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
TRMT13 for disorders About GeneDecksing 1 disease for TRMT13 : About MalaCards homocysteine Export disorders for TRMT13 gene to outside databases
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Publicationsfor TRMT13 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TRMT13 gene integrated from 9 sources : (articles sorted by number of sources associating them with TRMT13) Utopia : connect your pdf to the dynamic world of online information
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 1 , 2 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis. (PubMed id 11799066) 1 , 3 Weinmann A.S....Farnham P.J. (2002) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231) 2 Olsen J.V....Mann M. (2010) Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201) 1 Abdelmohsen K....Gorospe M. (2009) A novel CHHC Zn-finger domain found in spliceosomal proteins and tRNA modifying enzymes. (PubMed id 18703587) 2 Andreeva A. and Tidow H. (2008) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TRMT13 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TRMT13 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TRMT13 gene
(According to HUGE )
About This Section --
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Specialized Databases showing TRMT13 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for TRMT13 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for TRMT13 gene: Search GeneIP for patents involving TRMT13 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TRMT13 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for TRMT13 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TRMT13 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TRMT13 OriGene Protein Over-expression Lysate for TRMT13 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TRMT13 OriGene 3'-UTR Clone for TRMT13 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TRMT13 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TRMT13 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TRMT13 OriGene Custom Protein Services for TRMT13 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRMT13 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TRMT13 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TRMT13 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TRMT13 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TRMT13 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TRMT13
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TRMT13 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT13
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TRMT13
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Aliases for TRMT13
Databases for TRMT13
Disorders / Diseases for TRMT13
Domains / Families for TRMT13
Drugs / Compounds for TRMT13
Expression for TRMT13
Function for TRMT13
Genomic Views for TRMT13
Intellectual Property for TRMT13
Orthologs for TRMT13
Paralogs for TRMT13
Pathways / Interactions for TRMT13
Products for TRMT13
Proteins for TRMT13
Publications for TRMT13
Search Box for TRMT13
Summaries for TRMT13
Transcripts for TRMT13
Variants for TRMT13
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