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TRMT12 Gene

protein-coding   GIFtS: 46
GCID: GC08P125463

TRNA Methyltransferase 12 Homolog (S. Cerevisiae)

(Previous name: tRNA methyltranferase 12 homolog (S. cerevisiae))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TRNA Methyltransferase 12 Homolog (S. Cerevisiae)1 2     Homolog Of Yeast TRNA Methyltransferase2
TRM122 3 5     TRNA Methyltranferase 12 Homolog2
TRNA-YW Synthesizing Protein 21 2     TRNA Wybutosine-Synthesizing Protein 2 Homolog2
Alpha-Amino-Alpha-Carboxypropyl Transferase TYW22 3     EC 2.1.1.-3
TYW22 3     EC 2.5.1.-3
TRNA-YW-Synthesizing Protein 22 3     EC 2.1.18
TRNA Methyltranferase 12 Homolog (S. Cerevisiae)1     EC 2.1.1.328

External Ids:    HGNC: 260911   Entrez Gene: 550392   Ensembl: ENSG000001836657   OMIM: 6112445   UniProtKB: Q53H543   

Export aliases for TRMT12 gene to outside databases

Previous GC identifers: GC08P125534 GC08P120788


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRMT12 Gene:
Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine
tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TRMT12 is the human homolog of
a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).(supplied by OMIM, Mar 2008)

GeneCards Summary for TRMT12 Gene:
TRMT12 (tRNA methyltransferase 12 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with TRMT12 include noma, and breast cancer. GO annotations related to this gene include methyltransferase activity.

UniProtKB/Swiss-Prot: TYW2_HUMAN, Q53H54
Function: Probable S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine
biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position
adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity)

Gene Wiki entry for TRMT12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRMT12 gene promoter:
         Max1   Pbx1a   SREBP-1c   Nkx5-1   SREBP-1b   GATA-2   Max   AREB6   SREBP-1a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRMT12 promoter sequence
   Search Chromatin IP Primers for TRMT12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRMT12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.13   Ensembl cytogenetic band:  8q24.13   HGNC cytogenetic band: 8q24.13

TRMT12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRMT12 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P125463:  view genomic region     (about GC identifiers)

Start:
125,463,048 bp from pter      End:
125,474,391 bp from pter
Size:
11,344 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TYW2_HUMAN, Q53H54 (See protein sequence)
Recommended Name: tRNA wybutosine-synthesizing protein 2 homolog  
Size: 448 amino acids; 50236 Da
Sequence caution: Sequence=AAH03057.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAH03057.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence
starting in position 371;
Secondary accessions: Q6PKB9 Q96F21 Q9NWK6

Explore the universe of human proteins at neXtProt for TRMT12: NX_Q53H54

Explore proteomics data for TRMT12 at MOPED

Selected DME Specific Peptides for TRMT12 (Q53H54) (see all 6)
 NLEINGV  GNITEKLR  VHACEWNP  LLSEDCFQA 


See TRMT12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_060426.2  
ENSEMBL proteins: 
 ENSP00000429771   ENSP00000329858  

TRMT12 Human Recombinant Protein Products:

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LSBio Antibodies in human, mouse, rat for TRMT12

TRMT12 Assay Products:

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Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR003402 tRNA_Trfase_Trm5/Tyw2

Graphical View of Domain Structure for InterPro Entry Q53H54

ProtoNet protein and cluster: Q53H54

1 Blocks protein domain: IPB003402 Family of unknown function Met10

UniProtKB/Swiss-Prot: TYW2_HUMAN, Q53H54
Similarity: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family


TRMT12 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: TYW2_HUMAN, Q53H54
Function: Probable S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine
biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position
adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity)

     Enzyme Numbers (IUBMB): EC 2.1.1.-1 EC 2.1.12 EC 2.1.1.322 EC 2.5.1.-1

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008168methyltransferase activity IEA--
GO:0016740transferase activity ----
     
TRMT12 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRMT12
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRMT12

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRMT12
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRMT12

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat TRMT12 using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate TRMT12:
hsa-miR-629* hsa-miR-32* hsa-miR-450b-5p
SwitchGear 3'UTR luciferase reporter plasmidTRMT12 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for TRMT12
Predesigned siRNA for gene silencing in human, mouse, rat TRMT12

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for TRMT12

Clone
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OriGene clones in human, mouse for TRMT12 (see all 7)
OriGene ORF clones in mouse, rat for TRMT12
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: TRMT12 (NM_017956)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRMT12
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRMT12

Cell Line
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GenScript Custom overexpressing Cell Line Services for TRMT12
Browse ESI BIO Cell Lines and PureStem Progenitors for TRMT12 
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT12


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
nucleus2
extracellular1
mitochondrion1
peroxisome1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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UniProtKB/Swiss-Prot: TYW2_HUMAN, Q53H54
Pathway: tRNA modification; wybutosine-tRNA(Phe) biosynthesis

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRMT12
Interactions:

    Search GeneGlobe Interaction Network for TRMT12

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

Selected Interacting proteins for TRMT12 (ENSP000003298584) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

InteractantInteraction Details
GeneCardExternal ID(s)
ETF1ENSP000003537414STRING: ENSP00000353741
GSPT1ENSP000003981314STRING: ENSP00000398131
GSPT2ENSP000003412474STRING: ENSP00000341247
CAP1ENSP000003618784STRING: ENSP00000361878
CAP2ENSP000002299224STRING: ENSP00000229922
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008033tRNA processing IEA--

TRMT12 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TRMT12 (TYW2)

1 HMDB Compound for TRMT12    About this table
CompoundSynonyms CAS #PubMed Ids
S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for TRMT12 gene: 
NM_017956.3  

Unigene Cluster for TRMT12:

TRNA methyltransferase 12 homolog (S. cerevisiae)
Hs.9925  [show with all ESTs]
Unigene Representative Sequence: NM_017956
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000521443 ENST00000522518 ENST00000328599(uc003yra.4)
miRNA
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3 qRT-PCR Assays for microRNAs that regulate TRMT12:
hsa-miR-629* hsa-miR-32* hsa-miR-450b-5p
SwitchGear 3'UTR luciferase reporter plasmidTRMT12 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for TRMT12
Predesigned siRNA for gene silencing in human, mouse, rat TRMT12
Clone
Products:
     
OriGene clones in human, mouse for TRMT12 (see all 7)
OriGene ORF clones in mouse, rat for TRMT12
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: TRMT12 (NM_017956)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRMT12
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRMT12
Primer
Products:
    
OriGene qPCR primer pairs and template standards for TRMT12
OriGene qSTAR qPCR primer pairs in human, mouse for TRMT12
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRMT12
  QuantiTect SYBR Green Assays in human, mouse, rat TRMT12
  QuantiFast Probe-based Assays in human, mouse, rat TRMT12

Additional mRNA sequence: 

AK000779.1 AK222727.1 AK225083.1 BC003057.2 BC011713.2 

3 DOTS entries:

DT.456135  DT.121488314  DT.97795533 

Selected AceView cDNA sequences (see all 69):

AA305469 AI768622 BM128389 AI624916 CR592089 BM472116 BQ013767 BU956459 
BX089632 BM450240 BC003057 AW470700 AL582936 AL582988 N71278 BQ358613 
NM_017956 BM728721 BM545771 CK819334 BX372344 CB112471 AL554485 CF272203 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TRMT12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TRMT12 Expression
About this image

TRMT12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TRMT12 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.9925
    Custom PCR Arrays for TRMT12
Primer
Products:
OriGene qPCR primer pairs and template standards for TRMT12
OriGene qSTAR qPCR primer pairs in human, mouse for TRMT12
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRMT12
QuantiTect SYBR Green Assays in human, mouse, rat TRMT12
QuantiFast Probe-based Assays in human, mouse, rat TRMT12
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT12

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for TRMT12 gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Trmt121 , 5 tRNA methyltranferase 12 homolog (S. cerevisiae)5
tRNA methyltranferase 121
82.53(n)1
81.38(a)1
  15 (25.09 cM)5
682601  NM_026642.21  NP_080918.21 
 588726495 
chicken
(Gallus gallus)
Aves TRMT121 tRNA methyltransferase 12 homolog (S. cerevisiae) 63.93(n)
61.59(a)
  422259  XM_420244.4  XP_420244.4 
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.38912 Transcribed sequence with weak similarity to protein more 74.36(n)    BX771664.1 
zebrafish
(Danio rerio)
Actinopterygii zgc:1533611 zgc:153361 55.87(n)
52.96(a)
  564925  NM_001077164.1  NP_001070632.1 
worm
(Caenorhabditis elegans)
Secernentea F40F9.106
Protein F40F9.10 (F40F9.10) mRNA, complete cds
23(a)
1 ↔ 1
V(9711464-9713632) WBGene00009586
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM12(YML005W)4 S-adenosylmethionine-dependent methyltransferase of more   --   13(260221-261609) 855008  NP_013709.1 
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G046701 AT4G04670 52.89(n)
47.22(a)
  825800  NM_116705.4  NP_567268.2 


ENSEMBL Gene Tree for TRMT12 (if available)
TreeFam Gene Tree for TRMT12 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TRMT12 gene

TRMT12 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for TRMT12
PGOHUM00000241464


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TRMT12 (see all 120)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1129512981,2
C,F--125461066(+) TAGCTC/AGTTCA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
rs1816843251,2
--125461080(+) AAAAGG/TTCTTG 1 -- us2k10--------
rs1150018941,2
F--125461204(+) ACTCCC/TCAGGA 1 -- us2k11Minor allele frequency- T:0.04WA 118
rs286683861,2
F--125461247(+) TGGGTT/CACAGA 1 -- us2k1 tfbs31Minor allele frequency- C:0.09WA 118
rs78129111,2
C,F,A,H--125461287(+) gtttcC/Ttactg 1 -- us2k120Minor allele frequency- T:0.47NS EA NA WA CSA 878
rs1841023011,2
--125461308(+) GTTCAC/TCCCAT 1 -- us2k10--------
rs1470296911,2
--125461404(+) TTTCAC/TTTGCA 1 -- us2k10--------
rs1151266481,2
F--125461534(+) TTGCAA/GAGGGA 1 -- us2k11Minor allele frequency- G:0.02WA 118
rs1164182711,2
C--125461559(+) TTCTGG/TTACTT 1 -- us2k10--------
rs1155481051,2
C,F--125461611(+) GAAGTC/TAGTGT 1 -- us2k11Minor allele frequency- T:0.06WA 118

HapMap Linkage Disequilibrium report for TRMT12 (125463048 - 125474391 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for TRMT12:    About this table    
Variant IDTypeSubtypePubMed ID
dgv7874n71CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing TRMT12
DNA2.0 Custom Variant and Variant Library Synthesis for TRMT12

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 611244    OMIM disorders: --

2 diseases for TRMT12:    
About MalaCards
noma    breast cancer


TRMT12 for disorders           About GeneDecksing


Export disorders for TRMT12 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TRMT12 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TRMT12)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis. (PubMed id 17150819)1, 3 Noma A. and Suzuki T. (Nucleic Acids Symp Ser (Oxf) 2006)
  2. A novel methyltransferase required for the formation of the hypermodified nucleoside wybutosine in eucaryotic tRNA. (PubMed id 16005430)1, 3 Kalhor H.R....Clarke S. (Biochem. Biophys. Res. Commun. 2005)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. Chromosome 8 BAC array comparative genomic hybridization and expression analysis identify amplification and overexpression of TRMT12 in breast cancer. (PubMed id 17440925)1 Rodriguez V....Chandrasekharappa S. (amp 2007)
  6. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  8. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (Gene 1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55039 HGNC: 26091 AceView: FLJ20772 Ensembl:ENSG00000183665 euGenes: HUgn55039
ECgene: TRMT12 H-InvDB: TRMT12

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TRMT12 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TRMT12 gene:
Search GeneIP for patents involving TRMT12

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 OriGene Antibodies for TRMT12   OriGene RNAi products in human, mouse, rat for TRMT12  
 OriGene qPCR primer pairs and template standards for TRMT12   OriGene Protein Over-expression Lysate for TRMT12  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for TRMT12  
 OriGene qSTAR qPCR primer pairs in human, mouse for TRMT12   OriGene Purified Protein for TRMT12  
 OriGene ORF clones in mouse, rat for TRMT12   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for TRMT12   OriGene Custom Protein Services for TRMT12  

 
 
 Block miRNA regulation of human, mouse, rat TRMT12 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TRMT12
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRMT12 Predesigned siRNA for gene silencing in human, mouse, rat TRMT12
 QuantiFast Probe-based Assays in human, mouse, rat TRMT12 QuantiTect SYBR Green Assays in human, mouse, rat TRMT12
 Custom PCR Arrays for TRMT12 Search Chromatin IP Primers for TRMT12
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRMT12  Search GeneGlobe Interaction Network for TRMT12
 Regulatory tfbs in TRMT12 promoter
 GenScript Custom Purified and Recombinant Proteins Services for TRMT12 GenScript cDNA clones with any tag delivered in your preferred vector for TRMT12
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 Search Tocris compounds for TRMT12 (TYW2)
 Browse Sino Biological Proteins
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 TRMT12 antibodies
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 Antibodies for TRMT12
 See all of Abcam's Antibodies, Kits and Proteins for TRMT12
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 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Browse Proteins at Cloud-Clone Corp.
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 Browse ESI BIO Cell Lines and PureStem Progenitors for TRMT12
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
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 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT12
 SwitchGear 3'UTR luciferase reporter plasmids for TRMT12
 SwitchGear Promoter luciferase reporter plasmids for TRMT12
 ThermoFisher Antibodies for TRMT12
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRMT12
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRMT12
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRMT12
 LSBio Antibodies in human, mouse, rat for TRMT12
Customized transgenic rodents for:
 Humanization
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 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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