Aliases for TRMT12 Gene
- TRNA Methyltransferase 12 Homolog (S. Cerevisiae) 2 3
- TRM12 3 4 6
- TRNA(Phe) (4-Demethylwyosine(37)-C(7)) Aminocarboxypropyltransferase 3 4
- TRNA-YW Synthesizing Protein 2 2 3
- TRNA-YW-Synthesizing Protein 2 3 4
- TYW2 3 4
- TRNA Methyltranferase 12 Homolog (S. Cerevisiae) 2
- Alpha-Amino-Alpha-Carboxypropyl Transferase TYW2 3
External Ids for TRMT12 Gene
Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TRMT12 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).[supplied by OMIM, Mar 2008]
GeneCards Summary for TRMT12 Gene
TRMT12 (TRNA Methyltransferase 12 Homolog (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with TRMT12 include noma. GO annotations related to this gene include methyltransferase activity.
UniProtKB/Swiss-Prot for TRMT12 Gene
S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.