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Aliases for TRMT12 Gene

Aliases for TRMT12 Gene

  • TRNA Methyltransferase 12 Homolog (S. Cerevisiae) 2 3 5
  • TRNA(Phe) (4-Demethylwyosine(37)-C(7)) Aminocarboxypropyltransferase 3 4
  • TRNA-YW Synthesizing Protein 2 2 3
  • TRNA-YW-Synthesizing Protein 2 3 4
  • TRM12 3 4
  • TYW2 3 4
  • TRNA Methyltranferase 12 Homolog (S. Cerevisiae) 2
  • Alpha-Amino-Alpha-Carboxypropyl Transferase TYW2 3
  • Homolog Of Yeast TRNA Methyltransferase 3
  • TRNA Methyltranferase 12 Homolog 3
  • EC 2.5.1.114 4
  • EC 2.1.1.32 63
  • EC 2.1.1 63

External Ids for TRMT12 Gene

Previous GeneCards Identifiers for TRMT12 Gene

  • GC08P125534
  • GC08P125463
  • GC08P120788

Summaries for TRMT12 Gene

Entrez Gene Summary for TRMT12 Gene

  • Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TRMT12 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).[supplied by OMIM, Mar 2008]

GeneCards Summary for TRMT12 Gene

TRMT12 (TRNA Methyltransferase 12 Homolog (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with TRMT12 include Noma. Among its related pathways are tRNA processing and Gene Expression. GO annotations related to this gene include transferase activity.

UniProtKB/Swiss-Prot for TRMT12 Gene

  • S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.

Gene Wiki entry for TRMT12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT12 Gene

Genomics for TRMT12 Gene

Regulatory Elements for TRMT12 Gene

Enhancers for TRMT12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRMT12 on UCSC Golden Path with GeneCards custom track

Promoters for TRMT12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRMT12 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRMT12 Gene

Chromosome:
8
Start:
124,450,807 bp from pter
End:
124,462,150 bp from pter
Size:
11,344 bases
Orientation:
Plus strand

Genomic View for TRMT12 Gene

Genes around TRMT12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRMT12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRMT12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT12 Gene

Proteins for TRMT12 Gene

  • Protein details for TRMT12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53H54-TYW2_HUMAN
    Recommended name:
    tRNA wybutosine-synthesizing protein 2 homolog
    Protein Accession:
    Q53H54
    Secondary Accessions:
    • Q6PKB9
    • Q96F21
    • Q9NWK6

    Protein attributes for TRMT12 Gene

    Size:
    448 amino acids
    Molecular mass:
    50236 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH03057.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH03057.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 371.; Evidence={ECO:0000305};

neXtProt entry for TRMT12 Gene

Proteomics data for TRMT12 Gene at MOPED

Selected DME Specific Peptides for TRMT12 Gene

Post-translational modifications for TRMT12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRMT12 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for TRMT12 Gene

Protein Domains for TRMT12 Gene

Suggested Antigen Peptide Sequences for TRMT12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q53H54

UniProtKB/Swiss-Prot:

TYW2_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
genes like me logo Genes that share domains with TRMT12: view

No data available for Gene Families for TRMT12 Gene

Function for TRMT12 Gene

Molecular function for TRMT12 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + 4-demethylwyosine(37) in tRNA(Phe) = S-methyl-5-thioadenosine + 7-((3S)-3-amino-3-carboxypropyl)-4-demethylwyosine(37) in tRNA(Phe).
UniProtKB/Swiss-Prot Function:
S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.

Enzyme Numbers (IUBMB) for TRMT12 Gene

Gene Ontology (GO) - Molecular Function for TRMT12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with TRMT12: view

Phenotypes for TRMT12 Gene

GenomeRNAi human phenotypes for TRMT12:
genes like me logo Genes that share phenotypes with TRMT12: view

Animal Model Products

CRISPR Products

miRNA for TRMT12 Gene

miRTarBase miRNAs that target TRMT12

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRMT12 Gene

Localization for TRMT12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRMT12 Gene COMPARTMENTS Subcellular localization image for TRMT12 gene
Compartment Confidence
cytosol 3
nucleus 3
mitochondrion 2
extracellular 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRMT12 Gene

Pathways & Interactions for TRMT12 Gene

genes like me logo Genes that share pathways with TRMT12: view

UniProtKB/Swiss-Prot Q53H54-TYW2_HUMAN

  • Pathway: tRNA modification; wybutosine-tRNA(Phe) biosynthesis.

Gene Ontology (GO) - Biological Process for TRMT12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006400 tRNA modification TAS --
genes like me logo Genes that share ontologies with TRMT12: view

No data available for SIGNOR curated interactions for TRMT12 Gene

Drugs & Compounds for TRMT12 Gene

(1) Drugs for TRMT12 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
genes like me logo Genes that share compounds with TRMT12: view

Transcripts for TRMT12 Gene

mRNA/cDNA for TRMT12 Gene

Unigene Clusters for TRMT12 Gene

TRNA methyltransferase 12 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT12 Gene

No ASD Table

Relevant External Links for TRMT12 Gene

GeneLoc Exon Structure for
TRMT12
ECgene alternative splicing isoforms for
TRMT12

Expression for TRMT12 Gene

mRNA expression in normal human tissues for TRMT12 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRMT12 Gene



SOURCE GeneReport for Unigene cluster for TRMT12 Gene Hs.9925

genes like me logo Genes that share expression patterns with TRMT12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TRMT12 Gene

Orthologs for TRMT12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRMT12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRMT12 35
  • 86.83 (n)
  • 84.47 (a)
TRMT12 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRMT12 35
  • 88.66 (n)
  • 87.59 (a)
TRMT12 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trmt12 35
  • 82.53 (n)
  • 81.38 (a)
Trmt12 16
Trmt12 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRMT12 35
  • 99.48 (n)
  • 99.11 (a)
TRMT12 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trmt12 35
  • 84.97 (n)
  • 82.61 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
OneToMany
-- 36
  • 62 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TRMT12 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRMT12 35
  • 63.93 (n)
  • 61.59 (a)
TRMT12 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3891 35
trmt12 35
  • 59.8 (n)
  • 58.58 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:153361 35
  • 55.87 (n)
  • 52.96 (a)
TRMT12 (1 of 2) 36
  • 50 (a)
OneToMany
TRMT12 (2 of 2) 36
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F40F9.10 36
  • 23 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM12 36
  • 19 (a)
OneToOne
TRM12 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G04670 35
  • 52.89 (n)
  • 47.22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToOne
Species with no ortholog for TRMT12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRMT12 Gene

ENSEMBL:
Gene Tree for TRMT12 (if available)
TreeFam:
Gene Tree for TRMT12 (if available)

Paralogs for TRMT12 Gene

Pseudogenes.org Pseudogenes for TRMT12 Gene

genes like me logo Genes that share paralogs with TRMT12: view

No data available for Paralogs for TRMT12 Gene

Variants for TRMT12 Gene

Sequence variations from dbSNP and Humsavar for TRMT12 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs3812475 - 124,451,009(+) AGCCT(C/T)GGTTT reference, missense
rs3812473 -- 124,450,842(+) GGCCG(G/T)GTGAG utr-variant-5-prime
rs3812474 -- 124,450,857(+) AGGCT(A/T)CCTTA utr-variant-5-prime
rs4132855 -- 124,449,880(-) ATCAC(C/T)GTTTC upstream-variant-2KB
rs11556913 -- 124,451,303(+) CCGAG(A/C/G/T)TGGAG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TRMT12 Gene

Variant ID Type Subtype PubMed ID
dgv7874n71 CNV Gain 21882294

Variation tolerance for TRMT12 Gene

Residual Variation Intolerance Score: 46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.71% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TRMT12 Gene

Disorders for TRMT12 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRMT12 Gene - From: GeneCards

Disorder Aliases PubMed IDs
noma
  • cancrum oris
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TRMT12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRMT12
genes like me logo Genes that share disorders with TRMT12: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRMT12 Gene

Publications for TRMT12 Gene

  1. Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis. (PMID: 17150819) Noma A. … Suzuki T. (Nucleic Acids Symp Ser (Oxf) 2006) 2 3 67
  2. A novel methyltransferase required for the formation of the hypermodified nucleoside wybutosine in eucaryotic tRNA. (PMID: 16005430) Kalhor H.R. … Clarke S. (Biochem. Biophys. Res. Commun. 2005) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Chromosome 8 BAC array comparative genomic hybridization and expression analysis identify amplification and overexpression of TRMT12 in breast cancer. (PMID: 17440925) Rodriguez V. … Chandrasekharappa S. (Genes Chromosomes Cancer 2007) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for TRMT12 Gene

Sources for TRMT12 Gene

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