Aliases for TRMT12 Gene
External Ids for TRMT12 Gene
Previous GeneCards Identifiers for TRMT12 Gene
Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TRMT12 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).[supplied by OMIM, Mar 2008]
GeneCards Summary for TRMT12 Gene
TRMT12 (TRNA Methyltransferase 12 Homolog (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with TRMT12 include noma. Among its related pathways are Gene Expression and tRNA modification in the nucleus and cytosol. GO annotations related to this gene include transferase activity.
UniProtKB/Swiss-Prot for TRMT12 Gene
S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.