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Aliases for TRMT12 Gene

Aliases for TRMT12 Gene

  • TRNA Methyltransferase 12 Homolog (S. Cerevisiae) 2 3
  • TRM12 3 4 6
  • TRNA(Phe) (4-Demethylwyosine(37)-C(7)) Aminocarboxypropyltransferase 3 4
  • TRNA-YW Synthesizing Protein 2 2 3
  • TRNA-YW-Synthesizing Protein 2 3 4
  • TYW2 3 4
  • TRNA Methyltranferase 12 Homolog (S. Cerevisiae) 2
  • Alpha-Amino-Alpha-Carboxypropyl Transferase TYW2 3
  • TRNA Wybutosine-Synthesizing Protein 2 Homolog 3
  • Homolog Of Yeast TRNA Methyltransferase 3
  • TRNA Methyltranferase 12 Homolog 3
  • EC 2.5.1.114 4
  • EC 2.1.1.32 63
  • EC 2.1.1 63

External Ids for TRMT12 Gene

Previous GeneCards Identifiers for TRMT12 Gene

  • GC08P125534
  • GC08P125463
  • GC08P120788

Summaries for TRMT12 Gene

Entrez Gene Summary for TRMT12 Gene

  • Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TRMT12 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).[supplied by OMIM, Mar 2008]

GeneCards Summary for TRMT12 Gene

TRMT12 (TRNA Methyltransferase 12 Homolog (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with TRMT12 include noma. GO annotations related to this gene include methyltransferase activity.

UniProtKB/Swiss-Prot for TRMT12 Gene

  • S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.

Gene Wiki entry for TRMT12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT12 Gene

Genomics for TRMT12 Gene

Regulatory Elements for TRMT12 Gene

Genomic Location for TRMT12 Gene

Start:
124,450,807 bp from pter
End:
124,462,150 bp from pter
Size:
11,344 bases
Orientation:
Plus strand

Genomic View for TRMT12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRMT12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT12 Gene

Proteins for TRMT12 Gene

  • Protein details for TRMT12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53H54-TYW2_HUMAN
    Recommended name:
    tRNA wybutosine-synthesizing protein 2 homolog
    Protein Accession:
    Q53H54
    Secondary Accessions:
    • Q6PKB9
    • Q96F21
    • Q9NWK6

    Protein attributes for TRMT12 Gene

    Size:
    448 amino acids
    Molecular mass:
    50236 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH03057.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH03057.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 371.; Evidence={ECO:0000305};

neXtProt entry for TRMT12 Gene

Proteomics data for TRMT12 Gene at MOPED

Selected DME Specific Peptides for TRMT12 Gene

Post-translational modifications for TRMT12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRMT12 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains for TRMT12 Gene

Protein Domains for TRMT12 Gene

Suggested Antigen Peptide Sequences for TRMT12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q53H54

UniProtKB/Swiss-Prot:

TYW2_HUMAN :
  • Q53H54
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
genes like me logo Genes that share domains with TRMT12: view

No data available for Gene Families for TRMT12 Gene

Function for TRMT12 Gene

Molecular function for TRMT12 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + 4-demethylwyosine(37) in tRNA(Phe) = S-methyl-5-thioadenosine + 7-((3S)-3-amino-3-carboxypropyl)-4-demethylwyosine(37) in tRNA(Phe).
UniProtKB/Swiss-Prot Function:
S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.

Enzyme Numbers (IUBMB) for TRMT12 Gene

Gene Ontology (GO) - Molecular Function for TRMT12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with TRMT12: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRMT12

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TRMT12 Gene

Localization for TRMT12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRMT12 Gene COMPARTMENTS Subcellular localization image for TRMT12 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRMT12 Gene

Pathways for TRMT12 Gene

SuperPathways for TRMT12 Gene

No Data Available

UniProtKB/Swiss-Prot Q53H54-TYW2_HUMAN

  • Pathway: tRNA modification; wybutosine-tRNA(Phe) biosynthesis.

Gene Ontology (GO) - Biological Process for TRMT12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008033 tRNA processing IEA --
genes like me logo Genes that share ontologies with TRMT12: view

No data available for Pathways by source for TRMT12 Gene

Compounds for TRMT12 Gene

(1) HMDB Compounds for TRMT12 Gene

Compound Synonyms Cas Number PubMed IDs
S-Adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
29908-03-0
genes like me logo Genes that share compounds with TRMT12: view

Transcripts for TRMT12 Gene

mRNA/cDNA for TRMT12 Gene

Unigene Clusters for TRMT12 Gene

TRNA methyltransferase 12 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRMT12

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT12 Gene

No ASD Table

Relevant External Links for TRMT12 Gene

GeneLoc Exon Structure for
TRMT12
ECgene alternative splicing isoforms for
TRMT12

Expression for TRMT12 Gene

mRNA expression in normal human tissues for TRMT12 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRMT12 Gene

SOURCE GeneReport for Unigene cluster for TRMT12 Gene Hs.9925

genes like me logo Genes that share expressions with TRMT12: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for TRMT12 Gene

Orthologs for TRMT12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRMT12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRMT12 35
  • 86.83 (n)
  • 84.47 (a)
TRMT12 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRMT12 35
  • 88.66 (n)
  • 87.59 (a)
TRMT12 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trmt12 35
  • 82.53 (n)
  • 81.38 (a)
Trmt12 16
Trmt12 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRMT12 35
  • 99.48 (n)
  • 99.11 (a)
TRMT12 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trmt12 35
  • 84.97 (n)
  • 82.61 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
OneToMany
-- 36
  • 62 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TRMT12 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRMT12 35
  • 63.93 (n)
  • 61.59 (a)
TRMT12 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3891 35
trmt12 35
  • 59.8 (n)
  • 58.58 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:153361 35
  • 55.87 (n)
  • 52.96 (a)
TRMT12 (1 of 2) 36
  • 50 (a)
OneToMany
TRMT12 (2 of 2) 36
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F40F9.10 36
  • 23 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM12 36
  • 19 (a)
OneToOne
TRM12 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G04670 35
  • 52.89 (n)
  • 47.22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToOne
Species with no ortholog for TRMT12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRMT12 Gene

ENSEMBL:
Gene Tree for TRMT12 (if available)
TreeFam:
Gene Tree for TRMT12 (if available)

Paralogs for TRMT12 Gene

Pseudogenes.org Pseudogenes for TRMT12 Gene

genes like me logo Genes that share paralogs with TRMT12: view

No data available for Paralogs for TRMT12 Gene

Variants for TRMT12 Gene

Sequence variations from dbSNP and Humsavar for TRMT12 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs3812473 -- 124,450,842(+) GGCCG(G/T)GTGAG utr-variant-5-prime
rs3812474 -- 124,450,857(+) AGGCT(A/T)CCTTA utr-variant-5-prime
rs3812475 - 124,451,009(+) AGCCT(C/T)GGTTT missense, reference
rs4132855 -- 124,449,880(-) ATCAC(C/T)GTTTC upstream-variant-2KB
rs4613980 -- 124,450,109(+) AGTGC(A/G)AAGTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRMT12 Gene

Variant ID Type Subtype PubMed ID
dgv7874n71 CNV Gain 21882294

Relevant External Links for TRMT12 Gene

HapMap Linkage Disequilibrium report
TRMT12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRMT12 Gene

Disorders for TRMT12 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for TRMT12 Gene in MalaCards »

(1) Diseases for TRMT12 Gene including...

genes like me logo Genes that share disorders with TRMT12: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TRMT12 Gene

Publications for TRMT12 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A novel methyltransferase required for the formation of the hypermodified nucleoside wybutosine in eucaryotic tRNA. (PMID: 16005430) Kalhor H.R. … Clarke S. (Biochem. Biophys. Res. Commun. 2005) 2 3
  4. Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis. (PMID: 17150819) Noma A. … Suzuki T. (Nucleic Acids Symp Ser (Oxf) 2006) 2 3
  5. Chromosome 8 BAC array comparative genomic hybridization and expression analysis identify amplification and overexpression of TRMT12 in breast cancer. (PMID: 17440925) Rodriguez V. … Chandrasekharappa S. (Genes Chromosomes Cancer 2007) 3

Products for TRMT12 Gene

Sources for TRMT12 Gene

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