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Aliases for TRMT112 Gene

Aliases for TRMT112 Gene

  • TRNA Methyltransferase 11-2 Homolog (S. Cerevisiae) 2 3 5
  • TRNA Methyltransferase 112 Homolog 3 4
  • Multifunctional Methyltransferase Subunit TRM112-Like Protein 3
  • TRM112-Like Protein 3
  • TRMT11-2 3
  • HSPC152 3
  • HSPC170 3
  • HTrm112 3
  • TRM112 3

External Ids for TRMT112 Gene

Previous GeneCards Identifiers for TRMT112 Gene

  • GC11M063841
  • GC11M064084
  • GC11M060411

Summaries for TRMT112 Gene

GeneCards Summary for TRMT112 Gene

TRMT112 (TRNA Methyltransferase 11-2 Homolog (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. GO annotations related to this gene include protein methyltransferase activity.

UniProtKB/Swiss-Prot for TRMT112 Gene

  • Participates both in methylation of protein and tRNA species. The heterodimer with HEMK2/N6AMT1 catalyzes N5-methylation of ETF1 on Gln-185, using S-adenosyl L-methionine as methyl donor. The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT112 Gene

Genomics for TRMT112 Gene

Regulatory Elements for TRMT112 Gene

Enhancers for TRMT112 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G064237 1.4 ENCODE dbSUPER 25.5 +72.8 72766 16.6 CREB3L1 MLX AGO1 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC ENSG00000257086 TRMT112 TRPT1 ZFPL1 PPP1R14B LOC102723878 VEGFB KCNK4 PLCB3 FERMT3
GH11G064267 1.4 ENCODE dbSUPER 23.1 +47.4 47385 7.2 CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MCM3 NFYC ZFPL1 TRMT112 PLCB3 POLA2 LOC102723878 TRPT1 ENSG00000257086 KCNK4 DNAJC4 ESRRA
GH11G064316 1.4 ENCODE dbSUPER 21.3 -0.1 -51 4.1 HDGF PKNOX1 CREB3L1 ARNT AGO1 SIN3A ARID4B DMAP1 ZNF2 YY1 TRMT112 ZFPL1 POLA2 ENSG00000231680 PIR36303 PRDX5
GH11G064205 1.4 ENCODE dbSUPER 21.1 +110.5 110489 4.4 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZFPL1 TRPT1 ENSG00000257086 PLCB3 TRMT112 GPR137 BAD KCNK4 KCNK4-TEX40 ENSG00000207024
GH11G064120 1.5 Ensembl ENCODE dbSUPER 18.9 +195.8 195820 3.1 HDGF ARID4B SIN3A DMAP1 ZNF48 SLC30A9 ELK1 FOS KDM4B SP5 TRMT112 TRPT1 FLRT1 ENSG00000256341 GC11M064153 PIR54353
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRMT112 on UCSC Golden Path with GeneCards custom track

Promoters for TRMT112 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040650 184 2201 PKNOX1 CREB3L1 ARNT AGO1 SIN3A ARID4B DMAP1 ZNF2 YY1 ZNF143

Genomic Location for TRMT112 Gene

Chromosome:
11
Start:
64,316,460 bp from pter
End:
64,318,084 bp from pter
Size:
1,625 bases
Orientation:
Minus strand

Genomic View for TRMT112 Gene

Genes around TRMT112 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRMT112 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRMT112 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT112 Gene

Proteins for TRMT112 Gene

  • Protein details for TRMT112 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UI30-TR112_HUMAN
    Recommended name:
    Multifunctional methyltransferase subunit TRM112-like protein
    Protein Accession:
    Q9UI30
    Secondary Accessions:
    • B2R539
    • J3KNG5
    • Q3MHC7
    • Q8N2Z4

    Protein attributes for TRMT112 Gene

    Size:
    125 amino acids
    Molecular mass:
    14199 Da
    Quaternary structure:
    • Interacts with ALKBH8 and HEMK2/N6AMT1.

    Alternative splice isoforms for TRMT112 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRMT112 Gene

Post-translational modifications for TRMT112 Gene

  • Ubiquitination at Lys2, isoforms=48, and posLast=6868
  • Modification sites at PhosphoSitePlus

Other Protein References for TRMT112 Gene

No data available for DME Specific Peptides for TRMT112 Gene

Domains & Families for TRMT112 Gene

Protein Domains for TRMT112 Gene

Suggested Antigen Peptide Sequences for TRMT112 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UI30

UniProtKB/Swiss-Prot:

TR112_HUMAN :
  • Belongs to the TRM112 family.
Family:
  • Belongs to the TRM112 family.
genes like me logo Genes that share domains with TRMT112: view

No data available for Gene Families for TRMT112 Gene

Function for TRMT112 Gene

Molecular function for TRMT112 Gene

UniProtKB/Swiss-Prot Function:
Participates both in methylation of protein and tRNA species. The heterodimer with HEMK2/N6AMT1 catalyzes N5-methylation of ETF1 on Gln-185, using S-adenosyl L-methionine as methyl donor. The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species.

Gene Ontology (GO) - Molecular Function for TRMT112 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18539146
GO:0008276 protein methyltransferase activity IDA 18539146
genes like me logo Genes that share ontologies with TRMT112: view

Phenotypes for TRMT112 Gene

genes like me logo Genes that share phenotypes with TRMT112: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRMT112 Gene

Localization for TRMT112 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRMT112 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 3

Gene Ontology (GO) - Cellular Components for TRMT112 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0043234 protein complex IDA 18539146
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TRMT112: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRMT112 Gene

Pathways & Interactions for TRMT112 Gene

genes like me logo Genes that share pathways with TRMT112: view

Pathways by source for TRMT112 Gene

Gene Ontology (GO) - Biological Process for TRMT112 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006415 translational termination TAS --
GO:0018364 peptidyl-glutamine methylation IDA 18539146
GO:0030488 tRNA methylation IBA --
GO:0031167 rRNA methylation TAS --
GO:0032259 methylation TAS --
genes like me logo Genes that share ontologies with TRMT112: view

No data available for SIGNOR curated interactions for TRMT112 Gene

Drugs & Compounds for TRMT112 Gene

No Compound Related Data Available

Transcripts for TRMT112 Gene

Unigene Clusters for TRMT112 Gene

TRNA methyltransferase 11-2 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT112 Gene

No ASD Table

Relevant External Links for TRMT112 Gene

GeneLoc Exon Structure for
TRMT112
ECgene alternative splicing isoforms for
TRMT112

Expression for TRMT112 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRMT112 Gene

Protein differential expression in normal tissues from HIPED for TRMT112 Gene

This gene is overexpressed in Bone (12.7) and Peripheral blood mononuclear cells (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRMT112 Gene



Protein tissue co-expression partners for TRMT112 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRMT112 Gene:

TRMT112

SOURCE GeneReport for Unigene cluster for TRMT112 Gene:

Hs.333579

Evidence on tissue expression from TISSUES for TRMT112 Gene

  • Nervous system(4.8)
  • Adrenal gland(4.4)
  • Blood(4.3)
  • Lung(3.1)
  • Muscle(2.9)
  • Intestine(2.6)
  • Kidney(2.6)
  • Spleen(2.4)
  • Liver(2.3)
  • Stomach(2.3)
  • Heart(2.2)
  • Eye(2.1)
genes like me logo Genes that share expression patterns with TRMT112: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRMT112 Gene

Orthologs for TRMT112 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRMT112 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRMT112 34 35
  • 98.67 (n)
dog
(Canis familiaris)
Mammalia TRMT112 34
  • 86.93 (n)
-- 35
  • 83 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TRMT112 34 35
  • 84.8 (n)
rat
(Rattus norvegicus)
Mammalia Trmt112 34
  • 81.6 (n)
mouse
(Mus musculus)
Mammalia Trmt112 34 16 35
  • 79.73 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 64 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia trmt112 34
  • 62.02 (n)
Str.15155 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6431 34
zebrafish
(Danio rerio)
Actinopterygii trmt112 34 35
  • 60.06 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006575 34
  • 56.94 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12975 34 35
  • 55.46 (n)
worm
(Caenorhabditis elegans)
Secernentea C04H5.1 35
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM112 35 37
  • 28 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G22270 34
  • 51.91 (n)
rice
(Oryza sativa)
Liliopsida Os07g0623000 34
  • 54.84 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6839 35
  • 44 (a)
OneToMany
Species where no ortholog for TRMT112 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRMT112 Gene

ENSEMBL:
Gene Tree for TRMT112 (if available)
TreeFam:
Gene Tree for TRMT112 (if available)

Paralogs for TRMT112 Gene

genes like me logo Genes that share paralogs with TRMT112: view

No data available for Paralogs for TRMT112 Gene

Variants for TRMT112 Gene

Sequence variations from dbSNP and Humsavar for TRMT112 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000039151 -- 64,317,749(+) CGGCG(C/T)ACGCC upstream-variant-2KB, utr-variant-5-prime
rs1002157591 -- 64,318,958(+) CGGGG(G/T)CTTAC intron-variant, upstream-variant-2KB
rs1002492776 -- 64,318,856(+) CCCCC(C/G)CCTCG intron-variant, upstream-variant-2KB
rs1002531308 -- 64,319,295(+) ACCTG(C/T)CGCTG intron-variant, upstream-variant-2KB
rs1003482317 -- 64,318,111(+) GCGGC(A/C)CAGGC upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TRMT112 Gene

Variant ID Type Subtype PubMed ID
dgv1963n54 CNV loss 21841781
esv2667562 CNV deletion 23128226
esv27107 CNV loss 19812545
esv3626659 CNV loss 21293372
nsv469961 CNV loss 18288195
nsv832186 CNV loss 17160897
nsv951010 CNV deletion 24416366

Variation tolerance for TRMT112 Gene

Residual Variation Intolerance Score: 47.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.25; 5.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRMT112 Gene

Human Gene Mutation Database (HGMD)
TRMT112
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRMT112

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRMT112 Gene

Disorders for TRMT112 Gene

Relevant External Links for TRMT112

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRMT112

No disorders were found for TRMT112 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRMT112 Gene

Publications for TRMT112 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 64
  2. Human AlkB homolog ABH8 is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival. (PMID: 20308323) Fu D. … Samson L.D. (Mol. Cell. Biol. 2010) 3 4 64
  3. HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1. (PMID: 18539146) Figaro S. … Heurgue-Hamard V. (FEBS Lett. 2008) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 64

Products for TRMT112 Gene

Sources for TRMT112 Gene

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