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Aliases for TRMT112 Gene

Aliases for TRMT112 Gene

  • TRNA Methyltransferase 11-2 Homolog (S. Cerevisiae) 2 3
  • TRNA Methyltransferase 112 Homolog 3 4
  • Multifunctional Methyltransferase Subunit TRM112-Like Protein 3
  • TRM112-Like Protein 3
  • TRMT11-2 3
  • HSPC152 3
  • HSPC170 3
  • TRM112 3

External Ids for TRMT112 Gene

Previous GeneCards Identifiers for TRMT112 Gene

  • GC11M063841
  • GC11M064084
  • GC11M060411

Summaries for TRMT112 Gene

GeneCards Summary for TRMT112 Gene

TRMT112 (TRNA Methyltransferase 11-2 Homolog (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include protein methyltransferase activity.

UniProtKB/Swiss-Prot for TRMT112 Gene

  • Participates both in methylation of protein and tRNA species. The heterodimer with HEMK2/N6AMT1 catalyzes N5-methylation of ETF1 on Gln-185, using S-adenosyl L-methionine as methyl donor. The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT112 Gene

Genomics for TRMT112 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRMT112 Gene

Start:
64,316,460 bp from pter
End:
64,318,084 bp from pter
Size:
1,625 bases
Orientation:
Minus strand

Genomic View for TRMT112 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRMT112 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT112 Gene

No data available for Regulatory Elements for TRMT112 Gene

Proteins for TRMT112 Gene

  • Protein details for TRMT112 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UI30-TR112_HUMAN
    Recommended name:
    Multifunctional methyltransferase subunit TRM112-like protein
    Protein Accession:
    Q9UI30
    Secondary Accessions:
    • B2R539
    • J3KNG5
    • Q3MHC7
    • Q8N2Z4

    Protein attributes for TRMT112 Gene

    Size:
    125 amino acids
    Molecular mass:
    14199 Da
    Quaternary structure:
    • Interacts with ALKBH8 and HEMK2/N6AMT1.

    Alternative splice isoforms for TRMT112 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRMT112 Gene

Proteomics data for TRMT112 Gene at MOPED

Post-translational modifications for TRMT112 Gene

  • Ubiquitination at Lys48 and Lys68
  • Modification sites at PhosphoSitePlus

Other Protein References for TRMT112 Gene

No data available for DME Specific Peptides for TRMT112 Gene

Domains for TRMT112 Gene

Protein Domains for TRMT112 Gene

Suggested Antigen Peptide Sequences for TRMT112 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UI30

UniProtKB/Swiss-Prot:

TR112_HUMAN :
  • Q9UI30
Domain:
  • Contains 1 TRM112 domain.
Family:
  • Belongs to the TRM112 family.
genes like me logo Genes that share domains with TRMT112: view

No data available for Gene Families for TRMT112 Gene

Function for TRMT112 Gene

Molecular function for TRMT112 Gene

UniProtKB/Swiss-Prot Function: Participates both in methylation of protein and tRNA species. The heterodimer with HEMK2/N6AMT1 catalyzes N5-methylation of ETF1 on Gln-185, using S-adenosyl L-methionine as methyl donor. The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species.

Gene Ontology (GO) - Molecular Function for TRMT112 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18539146
GO:0008276 protein methyltransferase activity IDA 18539146
genes like me logo Genes that share ontologies with TRMT112: view

Animal Model Products

CRISPR Products

miRNA for TRMT112 Gene

miRTarBase miRNAs that target TRMT112

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRMT112

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TRMT112 Gene

Localization for TRMT112 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRMT112 Gene COMPARTMENTS Subcellular localization image for TRMT112 gene
Compartment Confidence
mitochondrion 3
cytoskeleton 1
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TRMT112 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043234 protein complex IDA 18539146
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TRMT112: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRMT112 Gene

Pathways for TRMT112 Gene

SuperPathways for TRMT112 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRMT112 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018364 peptidyl-glutamine methylation IDA 18539146
genes like me logo Genes that share ontologies with TRMT112: view

No data available for Pathways by source for TRMT112 Gene

Transcripts for TRMT112 Gene

Unigene Clusters for TRMT112 Gene

TRNA methyltransferase 11-2 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRMT112

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT112 Gene

No ASD Table

Relevant External Links for TRMT112 Gene

GeneLoc Exon Structure for
TRMT112
ECgene alternative splicing isoforms for
TRMT112

Expression for TRMT112 Gene

mRNA expression in normal human tissues for TRMT112 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRMT112 Gene

SOURCE GeneReport for Unigene cluster for TRMT112 Gene Hs.333579

genes like me logo Genes that share expressions with TRMT112: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRMT112 Gene

Orthologs for TRMT112 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRMT112 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRMT112 35
  • 98.67 (n)
  • 99.19 (a)
TRMT112 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRMT112 35
  • 84.8 (n)
  • 84 (a)
TRMT112 36
  • 84 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 83 (a)
OneToMany
TRMT112 35
  • 86.93 (n)
  • 83.2 (a)
mouse
(Mus musculus)
Mammalia Trmt112 35
  • 79.73 (n)
  • 80.8 (a)
Trmt112 16
Trmt112 36
  • 81 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Trmt112 35
  • 81.6 (n)
  • 80.8 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.6431 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15155 35
trmt112 35
  • 62.02 (n)
  • 62.3 (a)
zebrafish
(Danio rerio)
Actinopterygii trmt112 35
  • 60.06 (n)
  • 61.16 (a)
trmt112 36
  • 60 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006575 35
  • 56.94 (n)
  • 50 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12975 35
  • 55.46 (n)
  • 50.82 (a)
CG12975 36
  • 49 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C04H5.1 36
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM112 36
  • 28 (a)
OneToMany
TRM112 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G22270 35
  • 51.91 (n)
  • 46.72 (a)
rice
(Oryza sativa)
Liliopsida Os07g0623000 35
  • 54.84 (n)
  • 45.97 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6839 36
  • 44 (a)
OneToMany
Species with no ortholog for TRMT112:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRMT112 Gene

ENSEMBL:
Gene Tree for TRMT112 (if available)
TreeFam:
Gene Tree for TRMT112 (if available)

Paralogs for TRMT112 Gene

genes like me logo Genes that share paralogs with TRMT112: view

No data available for Paralogs for TRMT112 Gene

Variants for TRMT112 Gene

Structural Variations from Database of Genomic Variants (DGV) for TRMT112 Gene

Variant ID Type Subtype PubMed ID
dgv1156n71 CNV Loss 21882294
nsv469961 CNV Loss 18288195
dgv1163n71 CNV Loss 21882294
dgv1165n71 CNV Loss 21882294
dgv1166n71 CNV Loss 21882294
nsv832186 CNV Loss 17160897
nsv897685 CNV Loss 21882294

Relevant External Links for TRMT112 Gene

HapMap Linkage Disequilibrium report
TRMT112

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for TRMT112 Gene

Disorders for TRMT112 Gene

No disorders were found for TRMT112 Gene.

No data available for UniProtKB/Swiss-Prot for TRMT112 Gene

Publications for TRMT112 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  4. HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1. (PMID: 18539146) Figaro S. … Heurgue-Hamard V. (FEBS Lett. 2008) 3 4
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for TRMT112 Gene

Sources for TRMT112 Gene

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