TRMT112 Gene
protein-coding GIFtS: 41
GCID: GC11M064084
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|
tRNA methyltransferase 11-2 homolog (S. cerevisiae)
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Aliases
for TRMT112 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TRNA Methyltransferase 11-2 Homolog (S. Cerevisiae)1 2 | | TRMT11-21 2 | | HSPC1521 2 | | TRM112-Like Protein2 3 | | HSPC1701 2 | | TRNA Methyltransferase 112 Homolog2 | | TRM1121 2 | | |
Export aliases for TRMT112 gene to outside databasesPrevious GC identifers: GC11M063841 GC11M060411 |
Summaries
for TRMT112 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TR112_HUMAN, Q9UI30Function: Participates both in methylation of protein and tRNA species. The heterodimer with HEMK2/N6AMT1 catalyzesN5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor. The heterodimer with ALKBH8catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of theanticodon loop in target tRNA species
|
Genomic Views
for TRMT112 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TRMT112
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRMT112
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRMT112 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.1 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13.1TRMT112 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M064084: view genomic region
(about GC identifiers)
Start:
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64,083,932 bp from pter |
End:
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64,085,556 bp from pter |
Size:
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1,625 bases |
Orientation:
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minus strand |
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Proteins
for TRMT112 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TR112_HUMAN, Q9UI30 (See
protein sequence)Recommended Name: tRNA methyltransferase 112 homolog Size: 125 amino acids; 14199 Da
Subunit: Interacts with ALKBH8 and HEMK2/N6AMT1
Secondary accessions: B2R539 Q3MHC7 Q8N2Z4Explore the universe of human proteins at neXtProt for TRMT112: NX_Q9UI30
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UI30
TRMT112 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057488.1
ENSEMBL proteins: ENSP00000441279 ENSP00000444082 ENSP00000438349 ENSP00000309433 ENSP00000440437
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
TRMT112 for ontologies About GeneDecksing
TRMT112 Antibody Products:
Assay Products for TRMT112: |
Protein
Domains /
Families
for TRMT112 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRMT112 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9UI30ProtoNet protein and cluster: Q9UI30 1 Blocks protein family: IPB005651 Protein of unknown function DUF343
UniProtKB/Swiss-Prot: TR112_HUMAN, Q9UI30Similarity: Belongs to the TRM112 familySimilarity: Contains 1 TRM112 domain |
Function
for TRMT112 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TR112_HUMAN, Q9UI30Function: Participates both in methylation of protein and tRNA species. The heterodimer with HEMK2/N6AMT1 catalyzesN5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor. The heterodimer with ALKBH8catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of theanticodon loop in target tRNA species
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT112 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT112
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for TRMT112 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRMT112 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
TRMT112 for ontologies About GeneDecksing
|
Pathways & Interactions
for TRMT112 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRMT112
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/65 Interacting proteins for TRMT112 (Q9UI302, 3 ENSP000003094334) via UniProtKB, MINT, STRING, and/or I2D (see all 65)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0018364 | peptidyl-glutamine methylation |
IDA | 18539146 |
TRMT112 for ontologies About GeneDecksing
|
Drugs & Compounds
for TRMT112 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TRMT112
Search CenterWatch for drugs/clinical trials and news about TRMT112 / TR112
|
Transcripts
for TRMT112 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TRMT112 gene: NM_016404.1 Unigene Cluster for TRMT112: TRNA methyltransferase 11-2 homolog (S. cerevisiae) Hs.333579 [show with all ESTs]Unigene Representative Sequence: BM9088386 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000535750 ENST00000535126 ENST00000544844(uc001nzt.3) ENST00000537918
ENST00000308774 ENST00000539854
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT112 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT112
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TRMT112 (NM_016404) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRMT112 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRMT112 |
Additional cDNA sequence: AF110774.1 AF161501.1 AF229068.1 AK312050.1 BC017172.2 BC029482.2 BC105294.1 16 DOTS entries: DT.120754110 DT.100796191 DT.454045 DT.99951642 DT.120754131 DT.100796190 DT.100796196 DT.75155335 DT.87018088 DT.120754201 DT.120754246 DT.120956364 DT.100788946 DT.100788956 DT.100796194 DT.92032780 24/507 AceView cDNA sequences (see all 507): AV711170 BX953488 AL710288 BE795370 BM766950 AA771902 AI090772 BF433681 BM424149 N21259 BI713077 BE073622 BC017172 AA311004 AA995261 AA338799 AA913196 AI298248 H97236 BU785934 AA683410 AI582164 BF221713 AI217212
GeneLoc Exon Structure
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Expression
for TRMT112 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRMT112 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGCTGAGTG
About this image
See TRMT112 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRMT112
SOURCE GeneReport for Unigene cluster: Hs.333579
SABiosciences Custom PCR Arrays for TRMT112
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRMT112
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRMT112 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRMT112 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRMT112 |
Orthologs
for TRMT112 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TRMT112 gene from 7/27 species (see all 27) About this table
ENSEMBL Gene Tree for TRMT112 (if available)
TreeFam Gene Tree for TRMT112 (if available) |
Paralogs
for TRMT112 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TRMT112 gene
TRMT112 for paralogs About GeneDecksing
5/7 Pseudogenes.org Pseudogenes for TRMT112 (see all 7)
PGOHUM00000237139 PGOHUM00000239996 PGOHUM00000237790 PGOHUM00000246044 PGOHUM00000235289
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Genomic Variants
for TRMT112 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRMT112 |
|
Disorders
/ Diseases
for TRMT112 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TRMT112 for disorders About GeneDecksing
1  disease for TRMT112: About MalaCardsmalaria
Export disorders for TRMT112 gene to outside databases
|
Publications
for TRMT112 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRMT112 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with TRMT112) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
- HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1. (PubMed id 18539146)1, 2 Figaro S....Heurgue-Hamard V. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
- Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
|
External Searches for TRMT112 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TRMT112 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRMT112 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TRMT112 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TRMT112 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TRMT112 gene:
Search GeneIP for patents involving TRMT112
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TRMT112 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | TRMT112 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for TRMT112 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRMT112 |
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