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Aliases for TRMT11 Gene

Aliases for TRMT11 Gene

  • TRNA Methyltransferase 11 Homolog (S. Cerevisiae) 2 3
  • TRNA Guanosine-2-O-Methyltransferase TRM11 Homolog 3 4
  • C6orf75 3 4
  • TRNA (Guanine(10)-N2)-Methyltransferase Homolog 3
  • Chromosome 6 Open Reading Frame 75 2
  • EC 2.1.1.113 64
  • EC 2.1.1.- 4
  • TRMT11-1 3
  • EC 2.1.1 64
  • MDS024 3
  • TRM11 3

External Ids for TRMT11 Gene

Previous Symbols for TRMT11 Gene

  • C6orf75

Summaries for TRMT11 Gene

GeneCards Summary for TRMT11 Gene

TRMT11 (TRNA Methyltransferase 11 Homolog (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity and tRNA binding.

UniProtKB/Swiss-Prot for TRMT11 Gene

  • Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT11 Gene

Genomics for TRMT11 Gene

Genomic Location for TRMT11 Gene

Start:
125,986,430 bp from pter
End:
126,039,276 bp from pter
Size:
52,847 bases
Orientation:
Plus strand

Genomic View for TRMT11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRMT11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT11 Gene

Regulatory Elements for TRMT11 Gene

Proteins for TRMT11 Gene

  • Protein details for TRMT11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4G4-TRM11_HUMAN
    Recommended name:
    tRNA (guanine(10)-N2)-methyltransferase homolog
    Protein Accession:
    Q7Z4G4
    Secondary Accessions:
    • E1P570
    • Q5JY11
    • Q6PGQ5
    • Q9HC13

    Protein attributes for TRMT11 Gene

    Size:
    463 amino acids
    Molecular mass:
    53421 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRMT11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRMT11 Gene

Proteomics data for TRMT11 Gene at MOPED

Post-translational modifications for TRMT11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for TRMT11 Gene

UniProtKB/Swiss-Prot:

TRM11_HUMAN
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.:
    • Q7Z4G4
genes like me logo Genes that share domains with TRMT11: view

No data available for Gene Families for TRMT11 Gene

Function for TRMT11 Gene

Molecular function for TRMT11 Gene

UniProtKB/Swiss-Prot Function: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.

Enzyme Numbers (IUBMB) for TRMT11 Gene

Gene Ontology (GO) - Molecular Function for TRMT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IEA --
GO:0003677 DNA binding --
GO:0008168 methyltransferase activity IEA --
GO:0008170 N-methyltransferase activity --
genes like me logo Genes that share ontologies with TRMT11: view

miRNA for TRMT11 Gene

miRTarBase miRNAs that target TRMT11

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TRMT11 Gene

Localization for TRMT11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRMT11 Gene COMPARTMENTS Subcellular localization image for TRMT11 gene
Compartment Confidence
cytosol 2
golgi apparatus 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for TRMT11 Gene

Pathways for TRMT11 Gene

SuperPathways for TRMT11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRMT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006306 DNA methylation --
GO:0008033 tRNA processing IEA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with TRMT11: view

No data available for Pathways by source for TRMT11 Gene

Compounds for TRMT11 Gene

(1) HMDB Compounds for TRMT11 Gene

Compound Synonyms Cas Number PubMed IDs
S-Adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
29908-03-0
genes like me logo Genes that share compounds with TRMT11: view

Transcripts for TRMT11 Gene

Unigene Clusters for TRMT11 Gene

TRNA methyltransferase 11 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT11 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1: -
SP2: - - -
SP3:
SP4: - - - - - - - - - - - - -

Relevant External Links for TRMT11 Gene

GeneLoc Exon Structure for
TRMT11
ECgene alternative splicing isoforms for
TRMT11

Expression for TRMT11 Gene

mRNA expression in normal human tissues for TRMT11 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TRMT11 Gene

SOURCE GeneReport for Unigene cluster for TRMT11 Gene Hs.404186

genes like me logo Genes that share expressions with TRMT11: view

Orthologs for TRMT11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRMT11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRMT11 36
  • 99.64 (n)
  • 99.78 (a)
TRMT11 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRMT11 36
  • 91.88 (n)
  • 95.43 (a)
TRMT11 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRMT11 36
  • 92.25 (n)
  • 95.87 (a)
TRMT11 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trmt11 36
  • 89.71 (n)
  • 92.17 (a)
Trmt11 16
Trmt11 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRMT11 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRMT11 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trmt11 36
  • 88.62 (n)
  • 92.39 (a)
chicken
(Gallus gallus)
Aves TRMT11 36
  • 75.45 (n)
  • 77.12 (a)
TRMT11 37
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRMT11 37
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16718 36
trmt11 36
  • 72.33 (n)
  • 72.98 (a)
zebrafish
(Danio rerio)
Actinopterygii trmt11 36
  • 65.44 (n)
  • 69.41 (a)
trmt11 37
  • 69 (a)
OneToOne
zgc56233 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002384 36
  • 49.28 (n)
  • 43.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1074 36
  • 48.1 (n)
  • 42.28 (a)
CG1074 37
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y71F9AL.1 36
  • 47.88 (n)
  • 37.31 (a)
Y71F9AL.1 37
  • 35 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL161C 36
  • 44.74 (n)
  • 36.36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM11 36
  • 48.85 (n)
  • 36.99 (a)
TRM11 37
  • 34 (a)
OneToOne
TRM11 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C12903g 36
  • 49.32 (n)
  • 36.28 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G26410 36
  • 49.96 (n)
  • 41.97 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04407 36
  • 44.73 (n)
  • 38.56 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes trm11 36
  • 46.95 (n)
  • 35.96 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.613 36
Species with no ortholog for TRMT11:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRMT11 Gene

ENSEMBL:
Gene Tree for TRMT11 (if available)
TreeFam:
Gene Tree for TRMT11 (if available)

Paralogs for TRMT11 Gene

Pseudogenes.org Pseudogenes for TRMT11 Gene

genes like me logo Genes that share paralogs with TRMT11: view

No data available for Paralogs for TRMT11 Gene

Variants for TRMT11 Gene

Sequence variations from dbSNP and Humsavar for TRMT11 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs941458 -- 126,033,128(-) CCCAG(A/T)ATTTG intron-variant
rs960239 -- 126,032,908(-) CTACC(A/G)TAACT intron-variant
rs1268121 -- 126,031,440(-) TTGAG(C/T)GGCCA intron-variant
rs1268122 -- 126,028,834(-) TAGTT(A/C)TTTCT intron-variant
rs1268123 -- 126,022,112(-) gagcc(A/G)agatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRMT11 Gene

Variant ID Type Subtype PubMed ID
nsv830796 CNV Loss 17160897
nsv886636 CNV Loss 21882294
esv271340 CNV Insertion 20981092
nsv527938 CNV Loss 19592680

Relevant External Links for TRMT11 Gene

HapMap Linkage Disequilibrium report
TRMT11

Disorders for TRMT11 Gene

Relevant External Links for TRMT11

Genetic Association Database (GAD)
TRMT11
genes like me logo Genes that share disorders with TRMT11: view

No data available for UniProtKB/Swiss-Prot for TRMT11 Gene

Publications for TRMT11 Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3
  4. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3
  5. A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network. (PMID: 20308539) Lunardi A. … Collavin L. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3

Products for TRMT11 Gene

Sources for TRMT11 Gene

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