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Aliases for TRMT11 Gene

Aliases for TRMT11 Gene

  • TRNA Methyltransferase 11 Homolog (S. Cerevisiae) 2 3
  • TRNA Guanosine-2-O-Methyltransferase TRM11 Homolog 3 4
  • C6orf75 3 4
  • TRNA (Guanine(10)-N2)-Methyltransferase Homolog 3
  • Chromosome 6 Open Reading Frame 75 2
  • EC 63
  • EC 2.1.1.- 4
  • TRMT11-1 3
  • EC 2.1.1 63
  • MDS024 3
  • TRM11 3

External Ids for TRMT11 Gene

Previous HGNC Symbols for TRMT11 Gene

  • C6orf75

Previous GeneCards Identifiers for TRMT11 Gene

  • GC06P126350
  • GC06P126307
  • GC06P123883

Summaries for TRMT11 Gene

GeneCards Summary for TRMT11 Gene

TRMT11 (TRNA Methyltransferase 11 Homolog (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity and tRNA binding.

UniProtKB/Swiss-Prot for TRMT11 Gene

  • Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT11 Gene

Genomics for TRMT11 Gene

Regulatory Elements for TRMT11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRMT11 Gene

125,986,430 bp from pter
126,039,276 bp from pter
52,847 bases
Plus strand

Genomic View for TRMT11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRMT11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT11 Gene

Proteins for TRMT11 Gene

  • Protein details for TRMT11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    tRNA (guanine(10)-N2)-methyltransferase homolog
    Protein Accession:
    Secondary Accessions:
    • E1P570
    • Q5JY11
    • Q6PGQ5
    • Q9HC13

    Protein attributes for TRMT11 Gene

    463 amino acids
    Molecular mass:
    53421 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRMT11 Gene


neXtProt entry for TRMT11 Gene

Proteomics data for TRMT11 Gene at MOPED

Post-translational modifications for TRMT11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains for TRMT11 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q7Z4G4
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.
genes like me logo Genes that share domains with TRMT11: view

No data available for Gene Families for TRMT11 Gene

Function for TRMT11 Gene

Molecular function for TRMT11 Gene

UniProtKB/Swiss-Prot Function:
Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.

Enzyme Numbers (IUBMB) for TRMT11 Gene

Gene Ontology (GO) - Molecular Function for TRMT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IEA --
GO:0003677 DNA binding --
GO:0008168 methyltransferase activity IEA --
GO:0008170 N-methyltransferase activity --
genes like me logo Genes that share ontologies with TRMT11: view

Animal Model Products

CRISPR Products

miRNA for TRMT11 Gene

miRTarBase miRNAs that target TRMT11

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRMT11

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TRMT11 Gene

Localization for TRMT11 Gene

Subcellular locations from

Jensen Localization Image for TRMT11 Gene COMPARTMENTS Subcellular localization image for TRMT11 gene
Compartment Confidence
cytosol 2
golgi apparatus 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRMT11 Gene

Pathways for TRMT11 Gene

SuperPathways for TRMT11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRMT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006306 DNA methylation --
GO:0008033 tRNA processing IEA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with TRMT11: view

No data available for Pathways by source for TRMT11 Gene

Compounds for TRMT11 Gene

(1) HMDB Compounds for TRMT11 Gene

Compound Synonyms Cas Number PubMed IDs
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
genes like me logo Genes that share compounds with TRMT11: view

Transcripts for TRMT11 Gene

Unigene Clusters for TRMT11 Gene

TRNA methyltransferase 11 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRMT11

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT11 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1: -
SP2: - - -
SP4: - - - - - - - - - - - - -

Relevant External Links for TRMT11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRMT11 Gene

mRNA expression in normal human tissues for TRMT11 Gene

Protein differential expression in normal tissues for TRMT11 Gene

This gene is overexpressed in Heart (52.4) and Lung (13.6).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TRMT11 Gene

SOURCE GeneReport for Unigene cluster for TRMT11 Gene Hs.404186

genes like me logo Genes that share expressions with TRMT11: view

Expression partners for TRMT11 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRMT11 Gene

Orthologs for TRMT11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRMT11 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRMT11 35
  • 91.88 (n)
  • 95.43 (a)
TRMT11 36
  • 95 (a)
(Canis familiaris)
Mammalia TRMT11 35
  • 92.25 (n)
  • 95.87 (a)
TRMT11 36
  • 95 (a)
(Mus musculus)
Mammalia Trmt11 35
  • 89.71 (n)
  • 92.17 (a)
Trmt11 16
Trmt11 36
  • 92 (a)
(Pan troglodytes)
Mammalia TRMT11 35
  • 99.64 (n)
  • 99.78 (a)
TRMT11 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Trmt11 35
  • 88.62 (n)
  • 92.39 (a)
(Monodelphis domestica)
Mammalia TRMT11 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia TRMT11 36
  • 82 (a)
(Gallus gallus)
Aves TRMT11 35
  • 75.45 (n)
  • 77.12 (a)
TRMT11 36
  • 77 (a)
(Anolis carolinensis)
Reptilia TRMT11 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16718 35
trmt11 35
  • 72.33 (n)
  • 72.98 (a)
(Danio rerio)
Actinopterygii trmt11 35
  • 65.44 (n)
  • 69.41 (a)
zgc56233 35
trmt11 36
  • 69 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002384 35
  • 49.28 (n)
  • 43.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1074 35
  • 48.1 (n)
  • 42.28 (a)
CG1074 36
  • 38 (a)
(Caenorhabditis elegans)
Secernentea Y71F9AL.1 35
  • 47.88 (n)
  • 37.31 (a)
Y71F9AL.1 36
  • 35 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL161C 35
  • 44.74 (n)
  • 36.36 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C12903g 35
  • 49.32 (n)
  • 36.28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM11 35
  • 48.85 (n)
  • 36.99 (a)
TRM11 36
  • 34 (a)
TRM11 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G26410 35
  • 49.96 (n)
  • 41.97 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.613 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04407 35
  • 44.73 (n)
  • 38.56 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes trm11 35
  • 46.95 (n)
  • 35.96 (a)
Species with no ortholog for TRMT11:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRMT11 Gene

Gene Tree for TRMT11 (if available)
Gene Tree for TRMT11 (if available)

Paralogs for TRMT11 Gene Pseudogenes for TRMT11 Gene

genes like me logo Genes that share paralogs with TRMT11: view

No data available for Paralogs for TRMT11 Gene

Variants for TRMT11 Gene

Sequence variations from dbSNP and Humsavar for TRMT11 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs941458 -- 126,033,128(-) CCCAG(A/T)ATTTG intron-variant
rs960239 -- 126,032,908(-) CTACC(A/G)TAACT intron-variant
rs1268121 -- 126,031,440(-) TTGAG(C/T)GGCCA intron-variant
rs1268122 -- 126,028,834(-) TAGTT(A/C)TTTCT intron-variant
rs1268123 -- 126,022,112(-) gagcc(A/G)agatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRMT11 Gene

Variant ID Type Subtype PubMed ID
nsv830796 CNV Loss 17160897
nsv886636 CNV Loss 21882294
esv271340 CNV Insertion 20981092
nsv527938 CNV Loss 19592680

Relevant External Links for TRMT11 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRMT11 Gene

Disorders for TRMT11 Gene

Relevant External Links for TRMT11

Genetic Association Database (GAD)

No disorders were found for TRMT11 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TRMT11 Gene

Publications for TRMT11 Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3
  4. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3
  5. A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network. (PMID: 20308539) Lunardi A. … Collavin L. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3

Products for TRMT11 Gene

Sources for TRMT11 Gene

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