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Aliases for TRMT11 Gene

Aliases for TRMT11 Gene

  • TRNA Methyltransferase 11 Homolog 2 3 5
  • TRNA Guanosine-2-O-Methyltransferase TRM11 Homolog 3 4
  • C6orf75 3 4
  • TRNA Methyltransferase 11 Homolog (S. Cerevisiae) 2
  • Chromosome 6 Open Reading Frame 75 2
  • EC 2.1.1.113 63
  • EC 2.1.1.- 4
  • TRMT11-1 3
  • EC 2.1.1 63
  • MDS024 3
  • TRM11 3

External Ids for TRMT11 Gene

Previous HGNC Symbols for TRMT11 Gene

  • C6orf75

Previous GeneCards Identifiers for TRMT11 Gene

  • GC06P126350
  • GC06P126307
  • GC06P123883

Summaries for TRMT11 Gene

GeneCards Summary for TRMT11 Gene

TRMT11 (TRNA Methyltransferase 11 Homolog) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. GO annotations related to this gene include methyltransferase activity and N-methyltransferase activity.

UniProtKB/Swiss-Prot for TRMT11 Gene

  • Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT11 Gene

Genomics for TRMT11 Gene

Regulatory Elements for TRMT11 Gene

Promoters for TRMT11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRMT11 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRMT11 Gene

Chromosome:
6
Start:
125,986,430 bp from pter
End:
126,039,276 bp from pter
Size:
52,847 bases
Orientation:
Plus strand

Genomic View for TRMT11 Gene

Genes around TRMT11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRMT11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRMT11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT11 Gene

Proteins for TRMT11 Gene

  • Protein details for TRMT11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4G4-TRM11_HUMAN
    Recommended name:
    tRNA (guanine(10)-N2)-methyltransferase homolog
    Protein Accession:
    Q7Z4G4
    Secondary Accessions:
    • E1P570
    • Q5JY11
    • Q6PGQ5
    • Q9HC13

    Protein attributes for TRMT11 Gene

    Size:
    463 amino acids
    Molecular mass:
    53421 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRMT11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRMT11 Gene

Proteomics data for TRMT11 Gene at MOPED

Post-translational modifications for TRMT11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains & Families for TRMT11 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z4G4

UniProtKB/Swiss-Prot:

TRM11_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.
genes like me logo Genes that share domains with TRMT11: view

No data available for Gene Families for TRMT11 Gene

Function for TRMT11 Gene

Molecular function for TRMT11 Gene

UniProtKB/Swiss-Prot Function:
Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.

Enzyme Numbers (IUBMB) for TRMT11 Gene

Gene Ontology (GO) - Molecular Function for TRMT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004809 tRNA (guanine-N2-)-methyltransferase activity EXP 15899842
genes like me logo Genes that share ontologies with TRMT11: view
genes like me logo Genes that share phenotypes with TRMT11: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TRMT11

CRISPR Products

miRNA for TRMT11 Gene

miRTarBase miRNAs that target TRMT11

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRMT11 Gene

Localization for TRMT11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRMT11 Gene COMPARTMENTS Subcellular localization image for TRMT11 gene
Compartment Confidence
cytosol 3
golgi apparatus 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRMT11 Gene

Pathways & Interactions for TRMT11 Gene

genes like me logo Genes that share pathways with TRMT11: view

Pathways by source for TRMT11 Gene

Gene Ontology (GO) - Biological Process for TRMT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006400 tRNA modification TAS --
GO:0030488 tRNA methylation EXP 15899842
genes like me logo Genes that share ontologies with TRMT11: view

No data available for SIGNOR curated interactions for TRMT11 Gene

Drugs & Compounds for TRMT11 Gene

(1) Drugs for TRMT11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
genes like me logo Genes that share compounds with TRMT11: view

Transcripts for TRMT11 Gene

Unigene Clusters for TRMT11 Gene

TRNA methyltransferase 11 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT11 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1: -
SP2: - - -
SP3:
SP4: - - - - - - - - - - - - -

Relevant External Links for TRMT11 Gene

GeneLoc Exon Structure for
TRMT11
ECgene alternative splicing isoforms for
TRMT11

Expression for TRMT11 Gene

mRNA expression in normal human tissues for TRMT11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRMT11 Gene

This gene is overexpressed in Heart (52.4) and Lung (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRMT11 Gene



SOURCE GeneReport for Unigene cluster for TRMT11 Gene Hs.404186

genes like me logo Genes that share expression patterns with TRMT11: view

Protein tissue co-expression partners for TRMT11 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRMT11 Gene

Orthologs for TRMT11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRMT11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRMT11 35
  • 91.88 (n)
  • 95.43 (a)
TRMT11 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRMT11 35
  • 92.25 (n)
  • 95.87 (a)
TRMT11 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trmt11 35
  • 89.71 (n)
  • 92.17 (a)
Trmt11 16
Trmt11 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRMT11 35
  • 99.64 (n)
  • 99.78 (a)
TRMT11 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trmt11 35
  • 88.62 (n)
  • 92.39 (a)
oppossum
(Monodelphis domestica)
Mammalia TRMT11 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRMT11 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRMT11 35
  • 75.45 (n)
  • 77.12 (a)
TRMT11 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRMT11 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16718 35
trmt11 35
  • 72.33 (n)
  • 72.98 (a)
zebrafish
(Danio rerio)
Actinopterygii trmt11 35
  • 65.44 (n)
  • 69.41 (a)
zgc56233 35
trmt11 36
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002384 35
  • 49.28 (n)
  • 43.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1074 35
  • 48.1 (n)
  • 42.28 (a)
CG1074 36
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y71F9AL.1 35
  • 47.88 (n)
  • 37.31 (a)
Y71F9AL.1 36
  • 35 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL161C 35
  • 44.74 (n)
  • 36.36 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C12903g 35
  • 49.32 (n)
  • 36.28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM11 35
  • 48.85 (n)
  • 36.99 (a)
TRM11 36
  • 34 (a)
OneToOne
TRM11 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G26410 35
  • 49.96 (n)
  • 41.97 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.613 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04407 35
  • 44.73 (n)
  • 38.56 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes trm11 35
  • 46.95 (n)
  • 35.96 (a)
Species with no ortholog for TRMT11:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRMT11 Gene

ENSEMBL:
Gene Tree for TRMT11 (if available)
TreeFam:
Gene Tree for TRMT11 (if available)

Paralogs for TRMT11 Gene

Pseudogenes.org Pseudogenes for TRMT11 Gene

genes like me logo Genes that share paralogs with TRMT11: view

No data available for Paralogs for TRMT11 Gene

Variants for TRMT11 Gene

Sequence variations from dbSNP and Humsavar for TRMT11 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs17854915 - 126,008,401(+) CCTGC(A/C/T)GATAG nc-transcript-variant, reference, missense
rs941458 -- 126,033,128(-) CCCAG(A/T)ATTTG intron-variant
rs960239 -- 126,032,908(-) CTACC(A/G)TAACT intron-variant
rs1569737 -- 126,008,158(-) TTAAA(C/T)AGCAC intron-variant
rs1569738 -- 126,007,797(-) GTAAC(G/T)ATTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRMT11 Gene

Variant ID Type Subtype PubMed ID
nsv830796 CNV Loss 17160897
nsv886636 CNV Loss 21882294
esv271340 CNV Insertion 20981092
nsv527938 CNV Loss 19592680

Variation tolerance for TRMT11 Gene

Residual Variation Intolerance Score: 65.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.00; 49.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRMT11 Gene

HapMap Linkage Disequilibrium report
TRMT11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRMT11 Gene

Disorders for TRMT11 Gene

Relevant External Links for TRMT11

Genetic Association Database (GAD)
TRMT11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRMT11

No disorders were found for TRMT11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRMT11 Gene

Publications for TRMT11 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Germline predictors of androgen deprivation therapy response in advanced prostate cancer. (PMID: 22386179) Kohli M. … Cerhan J.R. (Mayo Clin. Proc. 2012) 3
  4. A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network. (PMID: 20308539) Lunardi A. … Collavin L. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3
  5. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PMID: 21102462) Elks C.E. … Murray A. (Nat. Genet. 2010) 3

Products for TRMT11 Gene

Sources for TRMT11 Gene

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