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Aliases for TRMT11 Gene

Aliases for TRMT11 Gene

  • TRNA Methyltransferase 11 Homolog 2 3 5
  • TRNA Guanosine-2-O-Methyltransferase TRM11 Homolog 3 4
  • C6orf75 3 4
  • TRNA Methyltransferase 11 Homolog (S. Cerevisiae) 2
  • TRNA (Guanine(10)-N2)-Methyltransferase Homolog 3
  • Chromosome 6 Open Reading Frame 75 2
  • EC 2.1.1.113 61
  • EC 2.1.1.- 4
  • TRMT11-1 3
  • EC 2.1.1 61
  • MDS024 3
  • TRM11 3

External Ids for TRMT11 Gene

Previous HGNC Symbols for TRMT11 Gene

  • C6orf75

Previous GeneCards Identifiers for TRMT11 Gene

  • GC06P126350
  • GC06P126307
  • GC06P123883

Summaries for TRMT11 Gene

GeneCards Summary for TRMT11 Gene

TRMT11 (TRNA Methyltransferase 11 Homolog) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. GO annotations related to this gene include methyltransferase activity and N-methyltransferase activity.

UniProtKB/Swiss-Prot for TRMT11 Gene

  • Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT11 Gene

Genomics for TRMT11 Gene

Regulatory Elements for TRMT11 Gene

Enhancers for TRMT11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G125940 2 FANTOM5 Ensembl ENCODE dbSUPER 4.2 -41.5 -41514 9.8 HDGF FOXA2 PKNOX1 MLX ARNT ARID4B DMAP1 FEZF1 YY1 ZNF766 NCOA7-AS1 HEY2 LOC105377986 NCOA7 TRMT11 PIR42096 HINT3
GH06G125955 1.8 FANTOM5 ENCODE dbSUPER 4.5 -29.4 -29370 3.7 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 SP3 TRMT11 NCOA7 HINT3 RNA5SP216
GH06G126054 1 ENCODE 5.2 +67.9 67918 0.5 PKNOX1 ATF1 CREB3L1 FEZF1 YY1 ZNF766 ELK1 GATA2 FOS NCOA1 HINT3 TRMT11 LOC101928096
GH06G126040 0.9 Ensembl ENCODE 4.7 +54.6 54583 1.2 CTCF ELF3 FOXA2 CEBPB MAX NR3C1 CEBPG DPF2 JUND ATF3 TRMT11 LOC101928096
GH06G125788 1.7 FANTOM5 ENCODE dbSUPER 1.5 -194.5 -194533 6.3 HDGF FOXA2 PKNOX1 CREB3L1 ARNT AGO1 ARID4B FEZF1 ZNF2 ZNF766 HEY2 HINT3 NCOA7-AS1 LOC105377986 NCOA7 TRMT11
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRMT11 on UCSC Golden Path with GeneCards custom track

Promoters for TRMT11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000202285 270 1801 HDGF MLX CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for TRMT11 Gene

Chromosome:
6
Start:
125,986,430 bp from pter
End:
126,039,276 bp from pter
Size:
52,847 bases
Orientation:
Plus strand

Genomic View for TRMT11 Gene

Genes around TRMT11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRMT11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRMT11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT11 Gene

Proteins for TRMT11 Gene

  • Protein details for TRMT11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4G4-TRM11_HUMAN
    Recommended name:
    tRNA (guanine(10)-N2)-methyltransferase homolog
    Protein Accession:
    Q7Z4G4
    Secondary Accessions:
    • E1P570
    • Q5JY11
    • Q6PGQ5
    • Q9HC13

    Protein attributes for TRMT11 Gene

    Size:
    463 amino acids
    Molecular mass:
    53421 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRMT11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRMT11 Gene

Selected DME Specific Peptides for TRMT11 Gene

Q7Z4G4:
  • MVPWHPCL
  • YLDVLVSDASKPSWRKGTYFDAIITDPPYGIRESTRR
  • YPVEKMVP
  • GGRLVYWLP
  • KKRHFIGNTSMDA
  • GHNSFREKYFSG
  • FGRWIADGQRELI
  • AHFGAYV
  • SNCEQKLSSHT
  • IPSEDIARNLMKRTVCAKS
  • TRRTGSQKE
  • LNRYLLLMAQEHLEFRLPEIKSLL
  • DIVFDPF

Post-translational modifications for TRMT11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for TRMT11 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z4G4

UniProtKB/Swiss-Prot:

TRM11_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.
genes like me logo Genes that share domains with TRMT11: view

Function for TRMT11 Gene

Molecular function for TRMT11 Gene

UniProtKB/Swiss-Prot Function:
Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.

Enzyme Numbers (IUBMB) for TRMT11 Gene

Gene Ontology (GO) - Molecular Function for TRMT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0004809 tRNA (guanine-N2-)-methyltransferase activity EXP 15899842
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with TRMT11: view
genes like me logo Genes that share phenotypes with TRMT11: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TRMT11

CRISPR Products

miRNA for TRMT11 Gene

miRTarBase miRNAs that target TRMT11

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRMT11 Gene

Localization for TRMT11 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRMT11 gene
Compartment Confidence
cytosol 3
golgi apparatus 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRMT11 Gene

Pathways & Interactions for TRMT11 Gene

genes like me logo Genes that share pathways with TRMT11: view

Pathways by source for TRMT11 Gene

Gene Ontology (GO) - Biological Process for TRMT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008033 tRNA processing IEA --
GO:0030488 tRNA methylation IEA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with TRMT11: view

No data available for SIGNOR curated interactions for TRMT11 Gene

Drugs & Compounds for TRMT11 Gene

(1) Drugs for TRMT11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
genes like me logo Genes that share compounds with TRMT11: view

Transcripts for TRMT11 Gene

Unigene Clusters for TRMT11 Gene

TRNA methyltransferase 11 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT11 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1: -
SP2: - - -
SP3:
SP4: - - - - - - - - - - - - -

Relevant External Links for TRMT11 Gene

GeneLoc Exon Structure for
TRMT11
ECgene alternative splicing isoforms for
TRMT11

Expression for TRMT11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRMT11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRMT11 Gene

This gene is overexpressed in Heart (52.4) and Lung (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRMT11 Gene



Protein tissue co-expression partners for TRMT11 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRMT11 Gene:

TRMT11

SOURCE GeneReport for Unigene cluster for TRMT11 Gene:

Hs.404186

Evidence on tissue expression from TISSUES for TRMT11 Gene

  • Liver(4.2)
  • Nervous system(2.6)
genes like me logo Genes that share expression patterns with TRMT11: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRMT11 Gene

Orthologs for TRMT11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRMT11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRMT11 34 35
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia TRMT11 34 35
  • 92.25 (n)
cow
(Bos Taurus)
Mammalia TRMT11 34 35
  • 91.88 (n)
mouse
(Mus musculus)
Mammalia Trmt11 34 16 35
  • 89.71 (n)
rat
(Rattus norvegicus)
Mammalia Trmt11 34
  • 88.62 (n)
oppossum
(Monodelphis domestica)
Mammalia TRMT11 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRMT11 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRMT11 34 35
  • 75.45 (n)
lizard
(Anolis carolinensis)
Reptilia TRMT11 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trmt11 34
  • 72.33 (n)
Str.16718 34
zebrafish
(Danio rerio)
Actinopterygii trmt11 34 35
  • 65.44 (n)
zgc56233 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002384 34
  • 49.28 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1074 34 35
  • 48.1 (n)
worm
(Caenorhabditis elegans)
Secernentea Y71F9AL.1 34 35
  • 47.88 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C12903g 34
  • 49.32 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM11 34 35 37
  • 48.85 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL161C 34
  • 44.74 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G26410 34
  • 49.96 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes trm11 34
  • 46.95 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04407 34
  • 44.73 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.613 34
Species where no ortholog for TRMT11 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRMT11 Gene

ENSEMBL:
Gene Tree for TRMT11 (if available)
TreeFam:
Gene Tree for TRMT11 (if available)

Paralogs for TRMT11 Gene

Pseudogenes.org Pseudogenes for TRMT11 Gene

genes like me logo Genes that share paralogs with TRMT11: view

No data available for Paralogs for TRMT11 Gene

Variants for TRMT11 Gene

Sequence variations from dbSNP and Humsavar for TRMT11 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000069262 -- 126,024,838(+) AAGGC(A/G)TTTTG intron-variant
rs1000109155 -- 126,053,021(+) CTTGC(C/T)CCTAT intron-variant
rs1000153322 -- 126,046,403(+) TTTAT(C/T)TGAGC intron-variant
rs1000167743 -- 125,992,543(+) TTTTG(A/G)TTCCC intron-variant
rs1000173943 -- 125,985,244(+) CTCAT(C/G)TGATT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRMT11 Gene

Variant ID Type Subtype PubMed ID
esv3307064 CNV mobile element insertion 20981092
esv3328863 CNV insertion 20981092
nsv1019490 CNV loss 25217958
nsv1022677 CNV gain 25217958
nsv1025069 CNV loss 25217958
nsv527938 CNV loss 19592680
nsv830796 CNV loss 17160897

Variation tolerance for TRMT11 Gene

Residual Variation Intolerance Score: 65.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.00; 49.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRMT11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRMT11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRMT11 Gene

Disorders for TRMT11 Gene

Relevant External Links for TRMT11

Genetic Association Database (GAD)
TRMT11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRMT11

No disorders were found for TRMT11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRMT11 Gene

Publications for TRMT11 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PMID: 22223895) Bienvenut W.V. … Giglione C. (Mol. Cell Proteomics 2012) 4 64
  5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 4 64

Products for TRMT11 Gene

Sources for TRMT11 Gene

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