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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRMT10C Gene

protein-coding   GIFtS: 40
GCID: GC03P101281

tRNA methyltransferase 10 homolog C (S. cerevisiae)

(Previous name: RNA (guanine-9-) methyltransferase domain containing 1...)
(Previous symbol: RG9MTD1)
 Explore 6 diseases affiliated with
TRMT10C via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TRMT10C    

Aliases
for TRMT10C gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
TRNA Methyltransferase 10 Homolog C (S. Cerevisiae)1 2     Mitochondrial Ribonuclease P Protein 12
MRPP11 2 3     Mitochondrial RNase P Subunit 12
RG9MTD11 2 3     EC 2.1.1.-3
RNA (Guanine-9-) Methyltransferase Domain Containing 11 2     Mitochondrial RNase P Protein 13
Renal Carcinoma Antigen NY-REN-492 3     RNA (Guanine-9-)-Methyltransferase Domain-Containing Protein 13
HBV Pre-S2 Trans-Regulated Protein 22 3     TRNA Methyltransferase 10 Homolog C3
FLJ204321     EC 2.1.18
HNYA2     EC 2.1.1.368

External Ids:    HGNC: 260221   Entrez Gene: 549312   Ensembl: ENSG000001741737   UniProtKB: Q7L0Y33   

Export aliases for TRMT10C gene to outside databases


Summaries
for TRMT10C gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TRMT10C:
This gene encodes the precursor of a subunit of the mitochondrial ribonuclease P, which is involved in 5' processing of
mitochondrial tRNAs. The encoded protein may confer RNA-binding capacity to mitochondrial ribonuclease P and may be
essential for transcript processing, RNA modification, translation and mitochondrial respiration. (provided by RefSeq,
Nov 2012)

UniProtKB/Swiss-Prot: MRRP1_HUMAN, Q7L0Y3
Function: Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of
MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends




Genomic Views
for TRMT10C gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TRMT10C
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRMT10C promoter sequence
   Search SABiosciences Chromatin IP Primers for TRMT10C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRMT10C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q12.3   Ensembl cytogenetic band:  3q12.3   HGNC cytogenetic band: 3q12.3

TRMT10C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRMT10C gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P101281:  view genomic region     (about GC identifiers)

Start:
 101,280,706 bp from pter      End:
 101,285,290 bp from pter
Size:
 4,585 bases      Orientation:
 plus strand

Proteins
for TRMT10C gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MRRP1_HUMAN, Q7L0Y3 (See protein sequence)
Recommended Name: Mitochondrial ribonuclease P protein 1 precursor  
Size: 403 amino acids; 47347 Da
Subunit: Interacts with MRPP2/HSD17B10 and MRPP3/KIAA0391
Subcellular location: Mitochondrion
Caution: It is uncertain whether Met-1 or Met-7 is the initiator
Sequence caution: Sequence=AAD42877.1; Type=Erroneous initiation; Sequence=AAH35967.2; Type=Erroneous initiation;
Sequence=BAA91166.1; Type=Frameshift; Positions=128;
Secondary accessions: Q9NRG5 Q9NX54 Q9Y596

Explore the universe of human proteins at neXtProt for TRMT10C: NX_Q7L0Y3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q7L0Y3

    • 4/7 DME Specific Peptides for TRMT10C (Q7L0Y3) (see all 7)
     YLTADSPN  DPFHIYFC  ESEGWNRR  NTVSQLLE 

    TRMT10C Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060289.2  
    ENSEMBL proteins: 
     ENSP00000312356   ENSP00000419389  

    Human Recombinant Protein Products: 
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    Uscn Proteins for TRMT10C

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005739mitochondrion IDA--


    TRMT10C for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for TRMT10C gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TRMT10C for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR016009 tRNA_m1G_MeTrfase
     IPR007356 tRNA_m1G_MeTrfase_euk
     IPR025812 Mt_RNase_P_1

    Graphical View of Domain Structure for InterPro Entry Q7L0Y3

    ProtoNet protein and cluster: Q7L0Y3

    UniProtKB/Swiss-Prot: MRRP1_HUMAN, Q7L0Y3
    Similarity: Belongs to the RNA methyltransferase TrmD family. TRM10 subfamily


    Function
    for TRMT10C gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MRRP1_HUMAN, Q7L0Y3
    Function: Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of
    MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends

    Enzyme Numbers (IUBMB): EC 2.1.1.362 EC 2.1.1.-1 EC 2.1.12

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18984158
    GO:0008168methyltransferase activity IEA--


    TRMT10C for ontologies           About GeneDecksing



    Pathways & Interactions
    for TRMT10C gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRMT10C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/247 Interacting proteins for TRMT10C (Q7L0Y31, 2, 3 ENSP000003123564) via UniProtKB, MINT, STRING, and/or I2D (see all 247)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSD17B10Q997141, 2, 3, ENSP000001682164EBI-2107046,EBI-79964 MINT-8079030 I2D: score=3 STRING: ENSP00000168216
    ENSG00000100890O150912, 3, ENSP000002503774MINT-8079030 I2D: score=1 STRING: ENSP00000250377
    KIAA0391O150912, 3MINT-8079030 I2D: score=1 
    RARS2Q5T1602, 3, ENSP000003585494MINT-8079030 I2D: score=1 STRING: ENSP00000358549
    SARS2Q9NP812, 3, ENSP000002214314MINT-8079030 I2D: score=1 STRING: ENSP00000221431
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008033tRNA processing IEA--


    TRMT10C for ontologies           About GeneDecksing



    Drugs & Compounds
    for TRMT10C gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRMT10C
    Search CenterWatch for drugs/clinical trials and news about TRMT10C / MRRP1 

    Transcripts
    for TRMT10C gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TRMT10C gene: 
    NM_017819.3  

    Unigene Clusters for TRMT10C:

    TRNA methyltransferase 10 homolog C (S. cerevisiae)
    Hs.744223  [show with all ESTs], Hs.744224  [show with all ESTs]
    Unigene Representative Sequences: AL561318, NM_017819
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309922(uc003duz.3) ENST00000495642

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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF226052.1 AK000439.1 AK026532.1 AY561707.1 BC035967.1 

    2 DOTS entries:

    DT.116014  DT.95079154 

    24/198 AceView cDNA sequences (see all 198):

    BM719461 AA481093 AI934446 BM992806 AF086243 AA721070 CB163572 BM472606 
    AA947751 CR626199 CR605158 CR621828 AA807488 BQ029747 BU170656 CR617309 
    AI220667 AW015832 AY561707 CB108136 CA434829 CR594278 BG289184 CB242023 

    GeneLoc Exon Structure


    Expression
    for TRMT10C gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    		 See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    TRMT10C expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    9 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor CellsSpinal Cord
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BoneAutopod Long BoneBone
    BoneCaudal Endochondral BonesBone
    BrainMedulla OblongataBrain
    BrainMidbrain tegmentumBrain
    Neural TubeMetencephalonNeural Tube
    Spinal CordSpinal Dorsal ColumnsSpinal Cord
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

    See TRMT10C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRMT10C

    SOURCE GeneReport for Unigene clusters: Hs.744223 Hs.744224
        SABiosciences Custom PCR Arrays for TRMT10C
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    In Situ
    Assay Products:     
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    Orthologs
    for TRMT10C gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TRMT10C gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RG9MTD11 RNA (guanine-9-) methyltransferase domain containing more 62.44(n)
    53.89(a)    		   418397  XM_416613.3  XP_416613.2 
    lizard
    (Anolis carolinensis)    		 Reptilia RG9MTD16
    		 --
    		 52(a)
    		 1 ↔ 1
    		 3(173623105-173624520)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.144072 Xenopus laevis transcribed sequence with weak similarity more 72.6(n)    BJ068885.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii trmt10c1 tRNA methyltransferase 10 homolog C (S. cerevisiae) 52.86(n)
    54.81(a)    		   492460  NM_001007332.1  NP_001007333.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG51901 CG5190 43.81(n)
    33.78(a)    		   37124  NM_137491.3  NP_611335.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea F46F11.101 Protein F46F11.10 42.93(n)
    28.16(a)    		   259376  NM_059246.3  NP_491647.3 


    ENSEMBL Gene Tree for TRMT10C (if available)
    TreeFam Gene Tree for TRMT10C (if available) 

    Paralogs
    for TRMT10C gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRMT10C gene
    TRMT10B2  TRMT10A2  

    TRMT10C for paralogs           About GeneDecksing



    Genomic Variants
    for TRMT10C gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/129 NCBI SNPs in TRMT10C are shown (see all 129)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1817198051,2
    		--101278715(+) TGGCGC/TAAACC 1 -- us2k10--------
    rs778994411,2
    		--101278933(+) GCTATA/GTTTAT 1 -- us2k10--------
    rs1869094271,2
    		--101279000(+) AATTTC/TCTTTA 1 -- us2k10--------
    rs76412611,2
    		C,F,H,--101279006(+) CTTTAC/TTTGAC 1 -- us2k113Minor allele frequency- T:0.23NS EA NA WA 920
    rs1905553661,2
    		--101279055(+) GAAAAA/TCTTCA 1 -- us2k10--------
    rs1824303611,2
    		--101279059(+) AACTTA/CAGATG 1 -- us2k10--------
    rs1870265841,2
    		--101279131(+) CTAGAC/TGATAT 1 -- us2k10--------
    rs1407546321,2
    		--101279214(+) CATGAC/TAGTAA 1 -- us2k10--------
    rs768327931,2
    		C,F,--101279254(+) AAAATC/TATTTG 1 -- us2k11Minor allele frequency- T:0.11WA 118
    rs729480561,2
    		C,--101279299(+) AACTAT/CATACA 1 -- us2k12Minor allele frequency- C:0.07WA 120

    HapMap Linkage Disequilibrium report for TRMT10C (101280706 - 101285290 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TRMT10C: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for TRMT10C gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TRMT10C for disorders           About GeneDecksing

    6 diseases for TRMT10C:    About MalaCards
    renal carcinoma    carcinoma    renal cell carcinoma    hepatitis b
    hepatitis    malaria


    Export disorders for TRMT10C gene to outside databases

    Publications
    for TRMT10C gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRMT10C gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with TRMT10C)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. RNase P without RNA: identification and functional reconstitution of the human mitochondrial tRNA processing enzyme. (PubMed id 18984158)1, 2, 3 Holzmann J....Rossmanith W. (2008)
    2. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (1999)
    3. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    4. Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). (PubMed id 21907836)1 Zhao J....Yang P. (2011)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. Involvement of human ELAC2 gene product in 3' end proc essing of mitochondrial tRNAs. (PubMed id 21593607)1 Brzezniak L.K....Stepien P.P. (2011)
    7. RNA processing in human mitochondria. (PubMed id 21857155)1 Sanchez M.I....Filipovska A. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Long noncoding RNAs are generated from the mitochondr ial genome and regulated by nuclear-encoded proteins. (PubMed id 22028365)1 Rackham O....Filipovska A. (2011)
    10. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)

    External Searches for TRMT10C gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing TRMT10C gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54931 HGNC: 26022 AceView: RG9MTD1 Ensembl:ENSG00000174173 euGenes: HUgn54931
    ECgene: TRMT10C H-InvDB: TRMT10C

    Other Databases showing TRMT10C gene

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    Specialized Databases showing TRMT10C gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRMT10C Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for TRMT10C gene:
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