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Aliases for TRMT10C Gene

Aliases for TRMT10C Gene

  • TRNA Methyltransferase 10 Homolog C (S. Cerevisiae) 2 3
  • RG9MTD1 3 4 6
  • MRPP1 3 4 6
  • RNA (Guanine-9-) Methyltransferase Domain Containing 1 2 3
  • HBV Pre-S2 Trans-Regulated Protein 2 3 4
  • Renal Carcinoma Antigen NY-REN-49 3 4
  • Mitochondrial RNase P Subunit 1 2 3
  • RNA (Guanine-9-)-Methyltransferase Domain-Containing Protein 1 4
  • Mitochondrial Ribonuclease P Protein 1 3
  • TRNA Methyltransferase 10 Homolog C 4
  • Mitochondrial RNase P Protein 1 4
  • EC 63
  • EC 2.1.1.- 4
  • EC 2.1.1 63
  • HNYA 3

External Ids for TRMT10C Gene

Previous HGNC Symbols for TRMT10C Gene

  • RG9MTD1

Previous GeneCards Identifiers for TRMT10C Gene

  • GC03P101281

Summaries for TRMT10C Gene

Entrez Gene Summary for TRMT10C Gene

  • This gene encodes the precursor of a subunit of the mitochondrial ribonuclease P, which is involved in 5' processing of mitochondrial tRNAs. The encoded protein may confer RNA-binding capacity to mitochondrial ribonuclease P and may be essential for transcript processing, RNA modification, translation and mitochondrial respiration. [provided by RefSeq, Nov 2012]

GeneCards Summary for TRMT10C Gene

TRMT10C (TRNA Methyltransferase 10 Homolog C (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is TRMT10A.

UniProtKB/Swiss-Prot for TRMT10C Gene

  • Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5-ends.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT10C Gene

Genomics for TRMT10C Gene

Genomic Location for TRMT10C Gene

101,561,836 bp from pter
101,566,446 bp from pter
4,611 bases
Plus strand

Genomic View for TRMT10C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRMT10C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT10C Gene

No data available for Regulatory Elements for TRMT10C Gene

Proteins for TRMT10C Gene

  • Protein details for TRMT10C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitochondrial ribonuclease P protein 1
    Protein Accession:
    Secondary Accessions:
    • Q9NRG5
    • Q9NX54
    • Q9Y596

    Protein attributes for TRMT10C Gene

    403 amino acids
    Molecular mass:
    47347 Da
    Quaternary structure:
    • Interacts with MRPP2/HSD17B10 and MRPP3/KIAA0391. Interacts with GRSF1.
    • Sequence=AAD42877.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH35967.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91166.1; Type=Frameshift; Positions=128; Evidence={ECO:0000305};

neXtProt entry for TRMT10C Gene

Proteomics data for TRMT10C Gene at MOPED

Selected DME Specific Peptides for TRMT10C Gene

Post-translational modifications for TRMT10C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRMT10C Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for TRMT10C Gene

Protein Domains for TRMT10C Gene

Graphical View of Domain Structure for InterPro Entry



  • Q7L0Y3
  • Contains 1 SAM-dependent MTase TRM10-type domain.
  • Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.
genes like me logo Genes that share domains with TRMT10C: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for TRMT10C Gene

Function for TRMT10C Gene

Molecular function for TRMT10C Gene

UniProtKB/Swiss-Prot Function: Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5-ends.

Enzyme Numbers (IUBMB) for TRMT10C Gene

Gene Ontology (GO) - Molecular Function for TRMT10C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18984158
GO:0008168 methyltransferase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with TRMT10C: view

miRNA for TRMT10C Gene

miRTarBase miRNAs that target TRMT10C

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TRMT10C Gene

Localization for TRMT10C Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRMT10C Gene

Mitochondrion matrix, mitochondrion nucleoid.

Gene Ontology (GO) - Cellular Components for TRMT10C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0042645 mitochondrial nucleoid IEA --
genes like me logo Genes that share ontologies with TRMT10C: view

No data available for Subcellular locations from COMPARTMENTS for TRMT10C Gene

Pathways for TRMT10C Gene

SuperPathways for TRMT10C Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRMT10C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000964 mitochondrial RNA 5-end processing IMP 21593607
GO:0008033 tRNA processing IEA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with TRMT10C: view

No data available for Pathways by source for TRMT10C Gene

Transcripts for TRMT10C Gene

mRNA/cDNA for TRMT10C Gene

(198) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRMT10C Gene

TRNA methyltransferase 10 homolog C (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT10C Gene

No ASD Table

Relevant External Links for TRMT10C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRMT10C Gene

mRNA expression in normal human tissues for TRMT10C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRMT10C Gene

SOURCE GeneReport for Unigene cluster for TRMT10C Gene Hs.740864

genes like me logo Genes that share expressions with TRMT10C: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRMT10C Gene

Orthologs for TRMT10C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRMT10C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RG9MTD1 35
  • 99.42 (n)
  • 98.76 (a)
RG9MTD1 36
  • 99 (a)
(Bos Taurus)
Mammalia TRMT10C 35
  • 88.25 (n)
  • 81.36 (a)
TRMT10C 36
  • 77 (a)
(Canis familiaris)
Mammalia TRMT10C 35
  • 85.08 (n)
  • 75.75 (a)
TRMT10C 36
  • 69 (a)
(Mus musculus)
Mammalia Trmt10c 35
  • 82.66 (n)
  • 77.53 (a)
Trmt10c 16
Trmt10c 36
  • 72 (a)
(Monodelphis domestica)
Mammalia TRMT10C 36
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia TRMT10C 36
  • 57 (a)
(Rattus norvegicus)
Mammalia Trmt10c 35
  • 81.73 (n)
  • 76.01 (a)
(Gallus gallus)
Aves TRMT10C 35
  • 62.33 (n)
  • 54.05 (a)
TRMT10C 36
  • 45 (a)
(Anolis carolinensis)
Reptilia TRMT10C 36
  • 46 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14407 35
tropical clawed frog
(Silurana tropicalis)
Amphibia trmt10c 35
  • 59.18 (n)
  • 51.34 (a)
(Danio rerio)
Actinopterygii trmt10c 35
  • 52.18 (n)
  • 50.76 (a)
trmt10c 36
  • 42 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007211 35
  • 46.04 (n)
  • 41.26 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5190 35
  • 45.99 (n)
  • 35.77 (a)
CG5190 36
  • 23 (a)
(Caenorhabditis elegans)
Secernentea F25H8.1 36
  • 21 (a)
F46F11.10 35
  • 43.14 (n)
  • 28.16 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM10 36
  • 19 (a)
Species with no ortholog for TRMT10C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRMT10C Gene

Gene Tree for TRMT10C (if available)
Gene Tree for TRMT10C (if available)

Paralogs for TRMT10C Gene

Paralogs for TRMT10C Gene

genes like me logo Genes that share paralogs with TRMT10C: view

Variants for TRMT10C Gene

Sequence variations from dbSNP and Humsavar for TRMT10C Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1292340 -- 101,561,526(+) ttttt(A/T)gtaga upstream-variant-2KB
rs1292341 -- 101,561,544(+) tttca(C/T)tatgt upstream-variant-2KB
rs1298455 -- 101,561,566(+) gtctc(A/G)aactc upstream-variant-2KB
rs1569071 -- 101,566,695(+) tcccc(C/G)acatt downstream-variant-500B
rs1976944 -- 101,566,576(+) ggacc(A/G)ggccc downstream-variant-500B

Relevant External Links for TRMT10C Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TRMT10C Gene

Disorders for TRMT10C Gene

No disorders were found for TRMT10C Gene.

No data available for UniProtKB/Swiss-Prot for TRMT10C Gene

Publications for TRMT10C Gene

  1. RNase P without RNA: identification and functional reconstitution of the human mitochondrial tRNA processing enzyme. (PMID: 18984158) Holzmann J. … Rossmanith W. (Cell 2008) 2 3 4
  2. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PMID: 10508479) Scanlan M.J. … Old L.J. (Int. J. Cancer 1999) 3 4
  3. Involvement of human ELAC2 gene product in 3' end processing of mitochondrial tRNAs. (PMID: 21593607) Brzezniak L.K. … Stepien P.P. (RNA Biol 2011) 3 4
  4. GRSF1 regulates RNA processing in mitochondrial RNA granules. (PMID: 23473034) Jourdain A.A. … Martinou J.C. (Cell Metab. 2013) 3 4
  5. The amyloid-I^-SDR5C1(ABAD) interaction does not mediate a specific inhibition of mitochondrial RNase P. (PMID: 23755257) Vilardo E. … Rossmanith W. (PLoS ONE 2013) 3

Products for TRMT10C Gene

Sources for TRMT10C Gene

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