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Aliases for TRMT10C Gene

Aliases for TRMT10C Gene

  • TRNA Methyltransferase 10C, Mitochondrial RNase P Subunit 2 3 5
  • RNA (Guanine-9-) Methyltransferase Domain Containing 1 2 3
  • HBV Pre-S2 Trans-Regulated Protein 2 3 4
  • TRNA Methyltransferase 10 Homolog C 3 4
  • Renal Carcinoma Antigen NY-REN-49 3 4
  • Mitochondrial RNase P Subunit 1 2 3
  • RG9MTD1 3 4
  • MRPP1 3 4
  • RNA (Guanine-9-)-Methyltransferase Domain-Containing Protein 1 4
  • TRNA Methyltransferase 10 Homolog C (S. Cerevisiae) 2
  • Mitochondrial RNase P Protein 1 4
  • EC 2.1.1.36 63
  • EC 2.1.1.- 4
  • EC 2.1.1 63
  • HNYA 3

External Ids for TRMT10C Gene

Previous HGNC Symbols for TRMT10C Gene

  • RG9MTD1

Previous GeneCards Identifiers for TRMT10C Gene

  • GC03P101281

Summaries for TRMT10C Gene

Entrez Gene Summary for TRMT10C Gene

  • This gene encodes the precursor of a subunit of the mitochondrial ribonuclease P, which is involved in 5' processing of mitochondrial tRNAs. The encoded protein may confer RNA-binding capacity to mitochondrial ribonuclease P and may be essential for transcript processing, RNA modification, translation and mitochondrial respiration. [provided by RefSeq, Nov 2012]

GeneCards Summary for TRMT10C Gene

TRMT10C (TRNA Methyltransferase 10C, Mitochondrial RNase P Subunit) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. GO annotations related to this gene include poly(A) RNA binding and methyltransferase activity. An important paralog of this gene is TRMT10A.

UniProtKB/Swiss-Prot for TRMT10C Gene

  • Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5-ends.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT10C Gene

Genomics for TRMT10C Gene

Regulatory Elements for TRMT10C Gene

Enhancers for TRMT10C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRMT10C on UCSC Golden Path with GeneCards custom track

Promoters for TRMT10C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRMT10C on UCSC Golden Path with GeneCards custom track

Genomic Location for TRMT10C Gene

Chromosome:
3
Start:
101,561,836 bp from pter
End:
101,566,446 bp from pter
Size:
4,611 bases
Orientation:
Plus strand

Genomic View for TRMT10C Gene

Genes around TRMT10C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRMT10C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRMT10C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT10C Gene

Proteins for TRMT10C Gene

  • Protein details for TRMT10C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L0Y3-MRRP1_HUMAN
    Recommended name:
    Mitochondrial ribonuclease P protein 1
    Protein Accession:
    Q7L0Y3
    Secondary Accessions:
    • Q9NRG5
    • Q9NX54
    • Q9Y596

    Protein attributes for TRMT10C Gene

    Size:
    403 amino acids
    Molecular mass:
    47347 Da
    Quaternary structure:
    • Interacts with MRPP2/HSD17B10 and MRPP3/KIAA0391. Interacts with GRSF1.
    SequenceCaution:
    • Sequence=AAD42877.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH35967.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91166.1; Type=Frameshift; Positions=128; Evidence={ECO:0000305};

neXtProt entry for TRMT10C Gene

Proteomics data for TRMT10C Gene at MOPED

Selected DME Specific Peptides for TRMT10C Gene

Post-translational modifications for TRMT10C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRMT10C Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for TRMT10C Gene

Protein Domains for TRMT10C Gene

Suggested Antigen Peptide Sequences for TRMT10C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L0Y3

UniProtKB/Swiss-Prot:

MRRP1_HUMAN :
  • Contains 1 SAM-dependent MTase TRM10-type domain.
  • Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.
Domain:
  • Contains 1 SAM-dependent MTase TRM10-type domain.
Family:
  • Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.
genes like me logo Genes that share domains with TRMT10C: view

No data available for Gene Families for TRMT10C Gene

Function for TRMT10C Gene

Molecular function for TRMT10C Gene

UniProtKB/Swiss-Prot Function:
Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5-ends.

Enzyme Numbers (IUBMB) for TRMT10C Gene

Gene Ontology (GO) - Molecular Function for TRMT10C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0009019 tRNA (guanine-N1-)-methyltransferase activity EXP 23042678
genes like me logo Genes that share ontologies with TRMT10C: view
genes like me logo Genes that share phenotypes with TRMT10C: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRMT10C Gene

Localization for TRMT10C Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRMT10C Gene

Mitochondrion matrix, mitochondrion nucleoid.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRMT10C Gene COMPARTMENTS Subcellular localization image for TRMT10C gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for TRMT10C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0042645 mitochondrial nucleoid IEA --
genes like me logo Genes that share ontologies with TRMT10C: view

Pathways & Interactions for TRMT10C Gene

genes like me logo Genes that share pathways with TRMT10C: view

Gene Ontology (GO) - Biological Process for TRMT10C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000964 mitochondrial RNA 5-end processing IMP 21593607
GO:0070901 mitochondrial tRNA methylation TAS --
genes like me logo Genes that share ontologies with TRMT10C: view

No data available for SIGNOR curated interactions for TRMT10C Gene

Drugs & Compounds for TRMT10C Gene

No Compound Related Data Available

Transcripts for TRMT10C Gene

mRNA/cDNA for TRMT10C Gene

Unigene Clusters for TRMT10C Gene

TRNA methyltransferase 10 homolog C (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT10C Gene

No ASD Table

Relevant External Links for TRMT10C Gene

GeneLoc Exon Structure for
TRMT10C
ECgene alternative splicing isoforms for
TRMT10C

Expression for TRMT10C Gene

mRNA expression in normal human tissues for TRMT10C Gene

Protein differential expression in normal tissues from HIPED for TRMT10C Gene

This gene is overexpressed in Lung (38.5) and Adrenal (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRMT10C Gene



SOURCE GeneReport for Unigene cluster for TRMT10C Gene Hs.740864

genes like me logo Genes that share expression patterns with TRMT10C: view

Protein tissue co-expression partners for TRMT10C Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRMT10C Gene

Orthologs for TRMT10C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRMT10C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRMT10C 35
  • 88.25 (n)
  • 81.36 (a)
TRMT10C 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRMT10C 35
  • 85.08 (n)
  • 75.75 (a)
TRMT10C 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trmt10c 35
  • 82.66 (n)
  • 77.53 (a)
Trmt10c 16
Trmt10c 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RG9MTD1 35
  • 99.42 (n)
  • 98.76 (a)
RG9MTD1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trmt10c 35
  • 81.73 (n)
  • 76.01 (a)
oppossum
(Monodelphis domestica)
Mammalia TRMT10C 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRMT10C 36
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRMT10C 35
  • 62.33 (n)
  • 54.05 (a)
TRMT10C 36
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRMT10C 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trmt10c 35
  • 59.18 (n)
  • 51.34 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14407 35
zebrafish
(Danio rerio)
Actinopterygii trmt10c 35
  • 52.18 (n)
  • 50.76 (a)
trmt10c 36
  • 42 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007211 35
  • 46.04 (n)
  • 41.26 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5190 35
  • 45.99 (n)
  • 35.77 (a)
CG5190 36
  • 23 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F46F11.10 35
  • 43.14 (n)
  • 28.16 (a)
F25H8.1 36
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM10 36
  • 19 (a)
OneToMany
Species with no ortholog for TRMT10C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRMT10C Gene

ENSEMBL:
Gene Tree for TRMT10C (if available)
TreeFam:
Gene Tree for TRMT10C (if available)

Paralogs for TRMT10C Gene

Paralogs for TRMT10C Gene

genes like me logo Genes that share paralogs with TRMT10C: view

Variants for TRMT10C Gene

Sequence variations from dbSNP and Humsavar for TRMT10C Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs3762735 - 101,564,948(+) TACAC(C/G)CCCTT reference, missense
rs16844031 - 101,565,273(+) ATCAA(C/G)CTGCT reference, missense
rs2303475 -- 101,561,920(+) GGATC(C/G/T)CTGGG utr-variant-5-prime
rs2303476 -- 101,562,149(+) ACTAG(C/T)ACAGT intron-variant
rs1292340 -- 101,561,526(+) ttttt(A/T)gtaga upstream-variant-2KB

Variation tolerance for TRMT10C Gene

Residual Variation Intolerance Score: 47.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.87; 74.14% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TRMT10C Gene

Disorders for TRMT10C Gene

Relevant External Links for TRMT10C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRMT10C

No disorders were found for TRMT10C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRMT10C Gene

Publications for TRMT10C Gene

  1. RNase P without RNA: identification and functional reconstitution of the human mitochondrial tRNA processing enzyme. (PMID: 18984158) Holzmann J. … Rossmanith W. (Cell 2008) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. (PMID: 24337577) Andresen C.A. … Flores-Morales A. (J. Biol. Chem. 2014) 3

Products for TRMT10C Gene

Sources for TRMT10C Gene

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