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Aliases for TRMT10B Gene

Aliases for TRMT10B Gene

  • TRNA Methyltransferase 10B 2 3 5
  • RNA (Guanine-9-)-Methyltransferase Domain-Containing Protein 3 3 4
  • RNA (Guanine-9-) Methyltransferase Domain Containing 3 2 3
  • RG9MTD3 3 4
  • TRNA Methyltransferase 10 Homolog B (S. Cerevisiae) 2
  • TRNA Methyltransferase 10 Homolog B 3
  • EC 2.1.1.- 4
  • BA3J10.9 3

External Ids for TRMT10B Gene

Previous HGNC Symbols for TRMT10B Gene

  • RG9MTD3

Previous GeneCards Identifiers for TRMT10B Gene

  • GC09P037754
  • GC09P037755
  • GC09P037756
  • GC09P037757
  • GC09P037758
  • GC09P037759
  • GC09P037760
  • GC09P037761
  • GC09P037762
  • GC09P037763

Summaries for TRMT10B Gene

GeneCards Summary for TRMT10B Gene

TRMT10B (TRNA Methyltransferase 10B) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is TRMT10C.

UniProtKB/Swiss-Prot for TRMT10B Gene

  • Probable RNA methyltransferase.

Additional gene information for TRMT10B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT10B Gene

Genomics for TRMT10B Gene

Regulatory Elements for TRMT10B Gene

Enhancers for TRMT10B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H037799 1.2 ENCODE 52.1 +47.9 47925 2 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC TRMT10B EXOSC3 ZCCHC7 POLR1E ZBTB5 LINC01400 SLC25A51 DCAF10
GH09H037323 2.3 FANTOM5 ENCODE dbSUPER 14.1 -428.6 -428615 3 PKNOX1 MXI1 BMI1 FEZF1 EBF1 POLR2A ZSCAN5C ATF7 IKZF2 CREM PAX5 TRMT10B ZBTB5 ZCCHC7 FBXO10 GC09P037324 RNU6-677P
GH09H038619 1 ENCODE 22.4 +867.4 867408 1 HDGF ARID4B SIN3A DMAP1 ZNF2 BRCA1 YY1 ZNF121 GLIS2 ELK1 TRMT10B EXOSC3 ANKRD18A DCAF10 FAM201A
GH09H037119 1.4 ENCODE dbSUPER 13.1 -632.3 -632323 2 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZCCHC7 EXOSC3 DCAF10 TRMT10B ZBTB5 HMGB3P24 GC09P037160
GH09H038175 0.7 dbSUPER 25.3 +423.1 423140 1 JUN ZFP64 ZNF140 ZNF697 FOSL1 CTBP1 NFE2 ZNF202 ZC3H11A MAFG TRMT10B EXOSC3 ZBTB5 DCAF10 ENSG00000200026 POLR1E PIR59956 PIR60591
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRMT10B on UCSC Golden Path with GeneCards custom track

Promoters for TRMT10B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000234898 796 1201 ATF1 ARNT ARID4B SIN3A ETS1 ZNF766 GLIS2 ZNF143 REST ZNF518A

Genomic Location for TRMT10B Gene

Chromosome:
9
Start:
37,753,204 bp from pter
End:
37,778,972 bp from pter
Size:
25,769 bases
Orientation:
Plus strand

Genomic View for TRMT10B Gene

Genes around TRMT10B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRMT10B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRMT10B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT10B Gene

Proteins for TRMT10B Gene

  • Protein details for TRMT10B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PF06-TM10B_HUMAN
    Recommended name:
    tRNA methyltransferase 10 homolog B
    Protein Accession:
    Q6PF06
    Secondary Accessions:
    • B7Z216
    • B7Z3D3
    • Q05DJ4
    • Q5QP83
    • Q8NAG2
    • Q96N36

    Protein attributes for TRMT10B Gene

    Size:
    316 amino acids
    Molecular mass:
    36124 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71074.1; Type=Erroneous termination; Positions=317; Note=Translated as stop.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRMT10B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRMT10B Gene

Post-translational modifications for TRMT10B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRMT10B Gene

Domains & Families for TRMT10B Gene

Gene Families for TRMT10B Gene

Protein Domains for TRMT10B Gene

Graphical View of Domain Structure for InterPro Entry

Q6PF06

UniProtKB/Swiss-Prot:

TM10B_HUMAN :
  • Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.
Family:
  • Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.
genes like me logo Genes that share domains with TRMT10B: view

Function for TRMT10B Gene

Molecular function for TRMT10B Gene

UniProtKB/Swiss-Prot Function:
Probable RNA methyltransferase.

Enzyme Numbers (IUBMB) for TRMT10B Gene

Gene Ontology (GO) - Molecular Function for TRMT10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0009019 tRNA (guanine-N1-)-methyltransferase activity IDA 23042678
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with TRMT10B: view

Phenotypes for TRMT10B Gene

GenomeRNAi human phenotypes for TRMT10B:
genes like me logo Genes that share phenotypes with TRMT10B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRMT10B Gene

Localization for TRMT10B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRMT10B gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRMT10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 23042678
genes like me logo Genes that share ontologies with TRMT10B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRMT10B Gene

Pathways & Interactions for TRMT10B Gene

SuperPathways for TRMT10B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRMT10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030488 tRNA methylation IEA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with TRMT10B: view

No data available for Pathways by source and SIGNOR curated interactions for TRMT10B Gene

Drugs & Compounds for TRMT10B Gene

No Compound Related Data Available

Transcripts for TRMT10B Gene

Unigene Clusters for TRMT10B Gene

TRNA methyltransferase 10 homolog B (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT10B Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - - -
SP5: - -
SP6: - - -
SP7: - -
SP8: -

Relevant External Links for TRMT10B Gene

GeneLoc Exon Structure for
TRMT10B
ECgene alternative splicing isoforms for
TRMT10B

Expression for TRMT10B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRMT10B Gene

NURSA nuclear receptor signaling pathways regulating expression of TRMT10B Gene:

TRMT10B

SOURCE GeneReport for Unigene cluster for TRMT10B Gene:

Hs.655614

Evidence on tissue expression from TISSUES for TRMT10B Gene

  • Nervous system(4.3)
  • Eye(4)
genes like me logo Genes that share expression patterns with TRMT10B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRMT10B Gene

Orthologs for TRMT10B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRMT10B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RG9MTD3 34
  • 100 (a)
OneToOne
TRMT10B 33
  • 99.89 (n)
dog
(Canis familiaris)
Mammalia TRMT10B 33 34
  • 90.51 (n)
cow
(Bos Taurus)
Mammalia TRMT10B 33 34
  • 88.71 (n)
mouse
(Mus musculus)
Mammalia Trmt10b 33 16 34
  • 82.33 (n)
rat
(Rattus norvegicus)
Mammalia Trmt10b 33
  • 81.1 (n)
oppossum
(Monodelphis domestica)
Mammalia TRMT10B 34
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRMT10B 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC768672 33
  • 61.36 (n)
TRMT10B 34
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRMT10B 34
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493764 33
  • 68.12 (n)
Str.616 33
zebrafish
(Danio rerio)
Actinopterygii trmt10b 33 34
  • 60.47 (n)
worm
(Caenorhabditis elegans)
Secernentea F25H8.1 34
  • 24 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM10 34
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 45 (a)
OneToOne
Species where no ortholog for TRMT10B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRMT10B Gene

ENSEMBL:
Gene Tree for TRMT10B (if available)
TreeFam:
Gene Tree for TRMT10B (if available)

Paralogs for TRMT10B Gene

Paralogs for TRMT10B Gene

Pseudogenes.org Pseudogenes for TRMT10B Gene

genes like me logo Genes that share paralogs with TRMT10B: view

Variants for TRMT10B Gene

Sequence variations from dbSNP and Humsavar for TRMT10B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs672601332 Pathogenic 37,780,795(-) GAATA(C/T)GGGTT downstream-variant-500B, reference, missense, utr-variant-3-prime
rs34753153 Likely benign 37,780,103(+) AAGCT(-/ATA)ATAAC nc-transcript-variant, utr-variant-3-prime, cds-indel
rs143319153 Uncertain significance 37,779,798(+) GTATC(C/T)CACAT nc-transcript-variant, utr-variant-3-prime
rs530037792 Uncertain significance 37,780,325(+) ACTTA(C/G/T)GTATT nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs530895640 Uncertain significance 37,779,725(+) TTTAT(C/T)AACAA nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TRMT10B Gene

Variant ID Type Subtype PubMed ID
esv3891658 CNV gain 25118596
nsv1125318 OTHER inversion 24896259
nsv469813 CNV loss 16826518
nsv469814 CNV gain 16826518
nsv831552 CNV gain 17160897

Variation tolerance for TRMT10B Gene

Residual Variation Intolerance Score: 46.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.34; 53.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRMT10B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRMT10B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRMT10B Gene

Disorders for TRMT10B Gene

Relevant External Links for TRMT10B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRMT10B

No disorders were found for TRMT10B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRMT10B Gene

Publications for TRMT10B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 60
  2. A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase--extensive moonlighting in mitochondrial tRNA biogenesis. (PMID: 23042678) Vilardo E … Rossmanith W (Nucleic acids research 2012) 2 3 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3 60

Products for TRMT10B Gene

Sources for TRMT10B Gene

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