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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRMT10B Gene

protein-coding   GIFtS: 37
GCID: GC09P037756

TRNA Methyltransferase 10 Homolog B (S. Cerevisiae)

(Previous name: RNA (guanine-9-) methyltransferase domain containing 3)
(Previous symbol: RG9MTD3)
  Search for TRMT10B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TRNA Methyltransferase 10 Homolog B (S. Cerevisiae)1 2     RP11-3J10.92
RG9MTD31 2 3     bA3J10.92
RNA (Guanine-9-) Methyltransferase Domain Containing 31 2     TRNA Methyltransferase 10 Homolog B2
RNA (Guanine-9-)-Methyltransferase Domain-Containing Protein 32 3     EC 2.1.1.-3

External Ids:    HGNC: 264541   Entrez Gene: 1582342   Ensembl: ENSG000001652757   UniProtKB: Q6PF063   

Export aliases for TRMT10B gene to outside databases

Previous GC identifers: GC09P037754 GC09P037755


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TRMT10B Gene: 
TRMT10B (tRNA methyltransferase 10 homolog B (S. cerevisiae)) is a protein-coding gene. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is TRMT10C.

UniProtKB/Swiss-Prot: TM10B_HUMAN, Q6PF06
Function: Probable RNA methyltransferase (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008413.18  NC_018920.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TRMT10B
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRMT10B promoter sequence
   Search SABiosciences Chromatin IP Primers for TRMT10B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRMT10B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.2   Ensembl cytogenetic band:  9p13.2   HGNC cytogenetic band: 9p13.1

TRMT10B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRMT10B gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P037756:  view genomic region     (about GC identifiers)

Start:
37,753,802 bp from pter      End:
37,778,969 bp from pter
Size:
25,168 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TM10B_HUMAN, Q6PF06 (See protein sequence)
Recommended Name: tRNA methyltransferase 10 homolog B  
Size: 316 amino acids; 36124 Da
Sequence caution: Sequence=BAB71074.1; Type=Erroneous termination; Positions=317; Note=Translated as stop;
Secondary accessions: Q05DJ4 Q5QP83 Q8NAG2 Q96N36
Alternative splicing: 3 isoforms:  Q6PF06-1   Q6PF06-2   Q6PF06-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRMT10B: NX_Q6PF06

Explore proteomics data for TRMT10B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6PF06

  • TRMT10B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRMT10B Protein Expression
    REFSEQ proteins: NP_659401.2  
    ENSEMBL proteins: 
     ENSP00000446050   ENSP00000445362   ENSP00000444612   ENSP00000437395   ENSP00000366983  
     ENSP00000297994   ENSP00000366982   ENSP00000444997  

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    Novus Biologicals TRMT10B Lysates
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR016653 tRNA_MeTfrase_TRM10
     IPR016009 tRNA_m1G_MeTrfase
     IPR007356 tRNA_m1G_MeTrfase_euk

    Graphical View of Domain Structure for InterPro Entry Q6PF06

    ProtoNet protein and cluster: Q6PF06

    UniProtKB/Swiss-Prot: TM10B_HUMAN, Q6PF06
    Similarity: Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family
    Similarity: Contains 1 SAM-dependent MTase TRM10-type domain


    TRMT10B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TM10B_HUMAN, Q6PF06
    Function: Probable RNA methyltransferase (By similarity)

         Enzyme Number (IUBMB): EC 2.1.1.-1

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008168methyltransferase activity IEA--
         
    TRMT10B for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRMT10B 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRMT10B 
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT10B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRMT10B

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TRMT10B (ENSP000002979944) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MEIS1ENSP000002723694STRING: ENSP00000272369
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRMT10B (TM10B)

    Search CenterWatch for drugs/clinical trials and news about TRMT10B / TM10B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRMT10B gene: 
    NM_144964.2  

    Unigene Cluster for TRMT10B:

    TRNA methyltransferase 10 homolog B (S. cerevisiae)
    Hs.655614  [show with all ESTs]
    Unigene Representative Sequence: NM_144964
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000540616 ENST00000538370 ENST00000537016 ENST00000488673 ENST00000377754
    ENST00000297994(uc011lqo.2 uc004aai.3 uc004aaj.3 uc004aak.3)
    ENST00000509577 ENST00000377753(uc011lqp.2 uc011lqq.2) ENST00000537911

    miRNA
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TRMT10B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRMT10B
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRMT10B
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    Primer
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    OriGene qPCR primer pairs and template standards for TRMT10B
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRMT10B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRMT10B

    Additional mRNA sequence: 

    AK056017.1 AK092718.1 AK294219.1 AK295733.1 AK304516.1 AK315922.1 BC012175.1 BC057774.1 

    12 DOTS entries:

    DT.95356515  DT.40297186  DT.70100884  DT.100680856  DT.209411  DT.95159287  DT.101976034  DT.121192829 
    DT.40111200  DT.95200346  DT.97806893  DT.97837068 

    24/70 AceView cDNA sequences (see all 70):

    CK299949 AA746199 CB131149 BU735348 BG472238 AA828484 BC057774 AI985517 
    AA320267 BQ082433 BX111785 BM792331 CA440955 BX119672 CA774635 AI914022 
    AI435297 BM820413 AI927954 AI279018 BC012175 BM450764 BE394309 BM463010 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TRMT10B (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                                  -                                             
    SP2:        -           -     -     -     -     -     -     -                                       
    SP3:        -           -     -     -                                                               
    SP4:                    -     -     -                 -                                             
    SP5:        -           -                                                                           


    ECgene alternative splicing isoforms for TRMT10B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRMT10B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TRMT10B Expression
    About this image


    See TRMT10B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRMT10B

    SOURCE GeneReport for Unigene cluster: Hs.655614
        SABiosciences Custom PCR Arrays for TRMT10B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT10B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TRMT10B gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trmt10b1 , 5 RNA (guanine-9-) methyltransferase domain containing more5
    tRNA methyltransferase 10B1
    82.33(n)1
    78.41(a)1
      4 (23.83 cM)5
    699341  NM_027266.41  NP_081542.21 
     452971275 
    chicken
    (Gallus gallus)
    Aves TRMT10B6
    tRNA methyltransferase 10 homolog B (S. cerevisiae...
    55(a)
    1 ↔ 1
    Z(81399015-81405150)
    lizard
    (Anolis carolinensis)
    Reptilia TRMT10B6
    Uncharacterized protein
    55(a)
    1 ↔ 1
    GL343201.1(3815393-3831295)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.6162 Transcribed sequence with weak similarity to protein more 73.08(n)    137721223 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1533411 zgc:153341 60.47(n)
    58.1(a)
      768135  NM_001077281.1  NP_001070749.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TRM106
    tRNA methyltransferase, methylates the N-1 positio...
    20(a)
    1 → many
    XV(142815-143696)


    ENSEMBL Gene Tree for TRMT10B (if available)
    TreeFam Gene Tree for TRMT10B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRMT10B gene
    TRMT10C2  TRMT10A2  

    TRMT10B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TRMT10B
    PGOHUM00000249775


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/712 SNPs in TRMT10B are shown (see all 712)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs284784581,2
    C--37751844(+) GGAGCC/TGGCTC 1 -- us2k10--------
    rs123799641,2
    C,F--37751862(+) ctgccG/Aggagg 1 -- us2k13Minor allele frequency- A:0.12WA NA EA 358
    rs1845528321,2
    --37751905(+) TGCTCC/GCAGGG 1 -- us2k10--------
    rs109735211,2
    C,F--37751918(+) CTTGCG/CGGCCA 1 -- us2k13Minor allele frequency- C:0.50NA CSA 6
    rs581489041,2
    C,F--37752139(+) AGCCCG/ACCATG 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1893130431,2
    --37752174(+) CCCTAA/CCCCTA 1 -- us2k10--------
    rs1824574841,2
    --37752180(+) CCCTAA/CCCCCA 1 -- us2k10--------
    rs1842094881,2
    --37752184(+) ACCCCC/TACCCC 1 -- us2k10--------
    rs1895807451,2
    --37752237(+) AGCCTC/TCCAGA 1 -- us2k10--------
    rs109735221,2
    C,F--37752330(+) GCAGGT/CAGCTT 1 -- us2k19Minor allele frequency- C:0.38NA WA CSA EA 369

    HapMap Linkage Disequilibrium report for TRMT10B (37753802 - 37778969 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TRMT10B: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TRMT10B
    DNA2.0 Custom Variant and Variant Library Synthesis for TRMT10B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRMT10B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TRMT10B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (2004)
    2. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 158234 HGNC: 26454 AceView: RG9MTD3 Ensembl:ENSG00000165275 euGenes: HUgn158234
    ECgene: TRMT10B H-InvDB: TRMT10B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRMT10B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRMT10B gene:
    Search GeneIP for patents involving TRMT10B

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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