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Aliases for TRMT10B Gene

Aliases for TRMT10B Gene

  • TRNA Methyltransferase 10B 2 3 5
  • RNA (Guanine-9-)-Methyltransferase Domain-Containing Protein 3 3 4
  • RNA (Guanine-9-) Methyltransferase Domain Containing 3 2 3
  • TRNA (Guanine(9)-N(1))-Methyltransferase TRMT10B 3 4
  • RG9MTD3 3 4
  • TRNA Methyltransferase 10 Homolog B (S. Cerevisiae) 2
  • TRNA Methyltransferase 10 Homolog B 3
  • EC 2.1.1.221 4
  • BA3J10.9 3

External Ids for TRMT10B Gene

Previous HGNC Symbols for TRMT10B Gene

  • RG9MTD3

Previous GeneCards Identifiers for TRMT10B Gene

  • GC09P037754
  • GC09P037755
  • GC09P037756
  • GC09P037757
  • GC09P037758
  • GC09P037759
  • GC09P037760
  • GC09P037761
  • GC09P037762
  • GC09P037763
  • GC09P037764

Summaries for TRMT10B Gene

GeneCards Summary for TRMT10B Gene

TRMT10B (TRNA Methyltransferase 10B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include methyltransferase activity. An important paralog of this gene is TRMT10A.

UniProtKB/Swiss-Prot for TRMT10B Gene

  • S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs (PubMed:23042678). Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs (PubMed:23042678).

Additional gene information for TRMT10B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT10B Gene

Genomics for TRMT10B Gene

GeneHancer (GH) Regulatory Elements for TRMT10B Gene

Promoters and enhancers for TRMT10B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I037753 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 565.4 +0.7 740 1.5 ATF1 ARNT ARID4B SIN3A ETS1 ZNF766 GLIS2 ZNF143 REST ZNF518A TRMT10B TMX2P1 SLC25A51 ZCCHC7 POLR1E DCAF10 ZBTB5 EXOSC3 GC09M037773 ENSG00000255872
GH09I037799 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 34.5 +47.9 47925 2.9 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 EXOSC3 DCAF10 TRMT10B ZBTB5 ZCCHC7 POLR1E SLC25A51 TMX2P1 RPL21P83 ENSG00000255872
GH09I037119 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13.1 -632.3 -632323 2.7 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B ZCCHC7 LOC105376034 EXOSC3 DCAF10 TRMT10B ZBTB5 HMGB3P24 GC09P037160
GH09I037902 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.7 +150.6 150570 3.4 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 SP3 NFYC SLC25A51 ZCCHC7 TRMT10B TMX2P1 EXOSC3 POLR1E PIR53315 PAICSP1 GC09M038093 ENSG00000255872
GH09I038619 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 14.1 +867.4 867411 2 HDGF ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF213 ZNF143 REST KAT8 ANKRD18A FAM201A TRMT10B EXOSC3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRMT10B on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRMT10B Gene

Genomic Locations for TRMT10B Gene
chr9:37,753,204-37,778,972
(GRCh38/hg38)
Size:
25,769 bases
Orientation:
Plus strand
chr9:37,753,802-37,778,969
(GRCh37/hg19)

Genomic View for TRMT10B Gene

Genes around TRMT10B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRMT10B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRMT10B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT10B Gene

Proteins for TRMT10B Gene

  • Protein details for TRMT10B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PF06-TM10B_HUMAN
    Recommended name:
    tRNA methyltransferase 10 homolog B
    Protein Accession:
    Q6PF06
    Secondary Accessions:
    • B7Z216
    • B7Z3D3
    • Q05DJ4
    • Q5QP83
    • Q8NAG2
    • Q96N36

    Protein attributes for TRMT10B Gene

    Size:
    316 amino acids
    Molecular mass:
    36124 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71074.1; Type=Erroneous termination; Positions=317; Note=Translated as stop.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRMT10B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRMT10B Gene

Post-translational modifications for TRMT10B Gene

No Post-translational modifications

No data available for DME Specific Peptides for TRMT10B Gene

Domains & Families for TRMT10B Gene

Gene Families for TRMT10B Gene

Protein Domains for TRMT10B Gene

Graphical View of Domain Structure for InterPro Entry

Q6PF06

UniProtKB/Swiss-Prot:

TM10B_HUMAN :
  • Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.
Family:
  • Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.
genes like me logo Genes that share domains with TRMT10B: view

Function for TRMT10B Gene

Molecular function for TRMT10B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + guanine(9) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(9) in tRNA.
UniProtKB/Swiss-Prot Function:
S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs (PubMed:23042678). Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs (PubMed:23042678).

Enzyme Numbers (IUBMB) for TRMT10B Gene

Gene Ontology (GO) - Molecular Function for TRMT10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0009019 tRNA (guanine-N1-)-methyltransferase activity IDA 23042678
GO:0016740 transferase activity IEA --
GO:0052905 tRNA (guanine(9)-N(1))-methyltransferase activity IEA --
genes like me logo Genes that share ontologies with TRMT10B: view

Phenotypes for TRMT10B Gene

GenomeRNAi human phenotypes for TRMT10B:
genes like me logo Genes that share phenotypes with TRMT10B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRMT10B Gene

Localization for TRMT10B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRMT10B gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRMT10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 23042678
genes like me logo Genes that share ontologies with TRMT10B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRMT10B Gene

Pathways & Interactions for TRMT10B Gene

SuperPathways for TRMT10B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRMT10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030488 tRNA methylation IEA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with TRMT10B: view

No data available for Pathways by source and SIGNOR curated interactions for TRMT10B Gene

Drugs & Compounds for TRMT10B Gene

No Compound Related Data Available

Transcripts for TRMT10B Gene

Unigene Clusters for TRMT10B Gene

TRNA methyltransferase 10 homolog B (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT10B Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - - -
SP5: - -
SP6: - - -
SP7: - -
SP8: -

Relevant External Links for TRMT10B Gene

GeneLoc Exon Structure for
TRMT10B
ECgene alternative splicing isoforms for
TRMT10B

Expression for TRMT10B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRMT10B Gene

NURSA nuclear receptor signaling pathways regulating expression of TRMT10B Gene:

TRMT10B

SOURCE GeneReport for Unigene cluster for TRMT10B Gene:

Hs.655614

Evidence on tissue expression from TISSUES for TRMT10B Gene

  • Nervous system(4.3)
  • Eye(4)
genes like me logo Genes that share expression patterns with TRMT10B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRMT10B Gene

Orthologs for TRMT10B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRMT10B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RG9MTD3 34
  • 100 (a)
OneToOne
TRMT10B 33
  • 99.89 (n)
dog
(Canis familiaris)
Mammalia TRMT10B 33 34
  • 90.51 (n)
cow
(Bos Taurus)
Mammalia TRMT10B 33 34
  • 88.71 (n)
mouse
(Mus musculus)
Mammalia Trmt10b 33 16 34
  • 82.33 (n)
rat
(Rattus norvegicus)
Mammalia Trmt10b 33
  • 81.1 (n)
oppossum
(Monodelphis domestica)
Mammalia TRMT10B 34
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRMT10B 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC768672 33
  • 61.36 (n)
TRMT10B 34
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRMT10B 34
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493764 33
  • 68.12 (n)
Str.616 33
zebrafish
(Danio rerio)
Actinopterygii trmt10b 33 34
  • 60.47 (n)
worm
(Caenorhabditis elegans)
Secernentea F25H8.1 34
  • 24 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM10 34
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 45 (a)
OneToOne
Species where no ortholog for TRMT10B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRMT10B Gene

ENSEMBL:
Gene Tree for TRMT10B (if available)
TreeFam:
Gene Tree for TRMT10B (if available)

Paralogs for TRMT10B Gene

Paralogs for TRMT10B Gene

Pseudogenes.org Pseudogenes for TRMT10B Gene

genes like me logo Genes that share paralogs with TRMT10B: view

Variants for TRMT10B Gene

Sequence variations from dbSNP and Humsavar for TRMT10B Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1059059 benign, Pontoneocerebellar hypoplasia 37,780,561(+) C/A/T downstream_transcript_variant
rs143319153 uncertain-significance, Pontoneocerebellar hypoplasia 37,779,798(+) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs3208406 conflicting-interpretations-of-pathogenicity, likely-benign, not specified, Pontoneocerebellar hypoplasia 37,780,834(+) A/G downstream_transcript_variant
rs34753153 likely-benign, Pontoneocerebellar hypoplasia 37,780,103(+) ATAATAA/ATAA 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs530037792 uncertain-significance, Pontoneocerebellar hypoplasia 37,780,325(+) G/C/T 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TRMT10B Gene

Variant ID Type Subtype PubMed ID
esv3891658 CNV gain 25118596
nsv1125318 OTHER inversion 24896259
nsv469813 CNV loss 16826518
nsv469814 CNV gain 16826518
nsv831552 CNV gain 17160897

Variation tolerance for TRMT10B Gene

Residual Variation Intolerance Score: 46.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.34; 53.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRMT10B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRMT10B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRMT10B Gene

Disorders for TRMT10B Gene

Additional Disease Information for TRMT10B

No disorders were found for TRMT10B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRMT10B Gene

Publications for TRMT10B Gene

  1. A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase--extensive moonlighting in mitochondrial tRNA biogenesis. (PMID: 23042678) Vilardo E … Rossmanith W (Nucleic acids research 2012) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3 58

Products for TRMT10B Gene

Sources for TRMT10B Gene

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