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Aliases for TRMT10B Gene

Aliases for TRMT10B Gene

  • TRNA Methyltransferase 10B 2 3 5
  • RNA (Guanine-9-)-Methyltransferase Domain-Containing Protein 3 3 4
  • RNA (Guanine-9-) Methyltransferase Domain Containing 3 2 3
  • RG9MTD3 3 4
  • TRNA Methyltransferase 10 Homolog B (S. Cerevisiae) 2
  • TRNA Methyltransferase 10 Homolog B 3
  • EC 2.1.1.- 4
  • BA3J10.9 3

External Ids for TRMT10B Gene

Previous HGNC Symbols for TRMT10B Gene

  • RG9MTD3

Previous GeneCards Identifiers for TRMT10B Gene

  • GC09P037754
  • GC09P037755
  • GC09P037756
  • GC09P037757
  • GC09P037758
  • GC09P037759
  • GC09P037760
  • GC09P037761
  • GC09P037762

Summaries for TRMT10B Gene

GeneCards Summary for TRMT10B Gene

TRMT10B (TRNA Methyltransferase 10B) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is TRMT10A.

UniProtKB/Swiss-Prot for TRMT10B Gene

  • Probable RNA methyltransferase.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT10B Gene

Genomics for TRMT10B Gene

Regulatory Elements for TRMT10B Gene

Enhancers for TRMT10B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G037799 1.2 ENCODE 31.9 +47.9 47925 2.9 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF416 ZNF143 EXOSC3 TRMT10B ZBTB5 SLC25A51 RPL21P83 DCAF10
GH09G037026 2 FANTOM5 Ensembl ENCODE dbSUPER 13.1 -721.0 -721011 12.4 HDGF PKNOX1 ARNT MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YBX1 PAX5 TRMT10B EXOSC3 ZCCHC7 LOC105376032 ZBTB5 LOC105376031
GH09G038045 1.6 Ensembl ENCODE dbSUPER 13.4 +294.4 294426 4.4 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 FOS TRMT10B RNU7-124P SLC25A51 SHB GC09P038069 GC09M038063
GH09G037119 1.4 ENCODE dbSUPER 13.1 -632.3 -632323 2.7 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 EXOSC3 TRMT10B ZBTB5 RPL21P83 ZCCHC7 GC09P037160
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRMT10B on UCSC Golden Path with GeneCards custom track

Promoters for TRMT10B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000234898 796 1201 ATF1 CREB3L1 ARNT ARID4B SIN3A YY1 ETS1 ZNF766 GLIS2 ZNF143

Genomic Location for TRMT10B Gene

37,753,204 bp from pter
37,778,972 bp from pter
25,769 bases
Plus strand

Genomic View for TRMT10B Gene

Genes around TRMT10B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRMT10B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRMT10B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT10B Gene

Proteins for TRMT10B Gene

  • Protein details for TRMT10B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    tRNA methyltransferase 10 homolog B
    Protein Accession:
    Secondary Accessions:
    • B7Z216
    • B7Z3D3
    • Q05DJ4
    • Q5QP83
    • Q8NAG2
    • Q96N36

    Protein attributes for TRMT10B Gene

    316 amino acids
    Molecular mass:
    36124 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB71074.1; Type=Erroneous termination; Positions=317; Note=Translated as stop.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRMT10B Gene


neXtProt entry for TRMT10B Gene

Post-translational modifications for TRMT10B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRMT10B Gene

Domains & Families for TRMT10B Gene

Gene Families for TRMT10B Gene

Protein Domains for TRMT10B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.
  • Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.
genes like me logo Genes that share domains with TRMT10B: view

Function for TRMT10B Gene

Molecular function for TRMT10B Gene

UniProtKB/Swiss-Prot Function:
Probable RNA methyltransferase.

Enzyme Numbers (IUBMB) for TRMT10B Gene

Gene Ontology (GO) - Molecular Function for TRMT10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009019 tRNA (guanine-N1-)-methyltransferase activity IDA 23042678
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with TRMT10B: view

Phenotypes for TRMT10B Gene

GenomeRNAi human phenotypes for TRMT10B:
genes like me logo Genes that share phenotypes with TRMT10B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRMT10B Gene

Localization for TRMT10B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRMT10B gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for TRMT10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 23042678
genes like me logo Genes that share ontologies with TRMT10B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRMT10B Gene

Pathways & Interactions for TRMT10B Gene

SuperPathways for TRMT10B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRMT10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030488 tRNA methylation IEA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with TRMT10B: view

No data available for Pathways by source and SIGNOR curated interactions for TRMT10B Gene

Drugs & Compounds for TRMT10B Gene

No Compound Related Data Available

Transcripts for TRMT10B Gene

Unigene Clusters for TRMT10B Gene

TRNA methyltransferase 10 homolog B (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT10B Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - - -
SP5: - -
SP6: - - -
SP7: - -
SP8: -

Relevant External Links for TRMT10B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRMT10B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRMT10B Gene

NURSA nuclear receptor signaling pathways regulating expression of TRMT10B Gene:


SOURCE GeneReport for Unigene cluster for TRMT10B Gene:


Evidence on tissue expression from TISSUES for TRMT10B Gene

  • Nervous system(4.3)
  • Eye(4)
genes like me logo Genes that share expression patterns with TRMT10B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRMT10B Gene

Orthologs for TRMT10B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRMT10B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RG9MTD3 35
  • 100 (a)
TRMT10B 34
  • 99.89 (n)
(Canis familiaris)
Mammalia TRMT10B 34 35
  • 90.51 (n)
(Bos Taurus)
Mammalia TRMT10B 34 35
  • 88.71 (n)
(Mus musculus)
Mammalia Trmt10b 34 16 35
  • 82.33 (n)
(Rattus norvegicus)
Mammalia Trmt10b 34
  • 81.1 (n)
(Monodelphis domestica)
Mammalia TRMT10B 35
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia TRMT10B 35
  • 62 (a)
(Gallus gallus)
Aves LOC768672 34
  • 61.36 (n)
TRMT10B 35
  • 56 (a)
(Anolis carolinensis)
Reptilia TRMT10B 35
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493764 34
  • 68.12 (n)
Str.616 34
(Danio rerio)
Actinopterygii trmt10b 34 35
  • 60.47 (n)
(Caenorhabditis elegans)
Secernentea F25H8.1 35
  • 24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM10 35
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 45 (a)
Species where no ortholog for TRMT10B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRMT10B Gene

Gene Tree for TRMT10B (if available)
Gene Tree for TRMT10B (if available)

Paralogs for TRMT10B Gene

Paralogs for TRMT10B Gene Pseudogenes for TRMT10B Gene

genes like me logo Genes that share paralogs with TRMT10B: view

Variants for TRMT10B Gene

Sequence variations from dbSNP and Humsavar for TRMT10B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs672601332 Pathogenic 37,780,795(-) GAATA(C/T)GGGTT downstream-variant-500B, reference, missense, utr-variant-3-prime
rs34753153 Likely benign 37,780,103(+) AAGCT(-/ATA)ATAAC nc-transcript-variant, utr-variant-3-prime, cds-indel
rs143319153 Uncertain significance 37,779,798(+) GTATC(C/T)CACAT nc-transcript-variant, utr-variant-3-prime
rs530037792 Uncertain significance 37,780,325(+) ACTTA(C/G/T)GTATT nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs530895640 Uncertain significance 37,779,725(+) TTTAT(C/T)AACAA nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TRMT10B Gene

Variant ID Type Subtype PubMed ID
esv3891658 CNV gain 25118596
nsv1125318 OTHER inversion 24896259
nsv469813 CNV loss 16826518
nsv469814 CNV gain 16826518
nsv831552 CNV gain 17160897

Variation tolerance for TRMT10B Gene

Residual Variation Intolerance Score: 46.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.34; 53.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRMT10B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRMT10B Gene

Disorders for TRMT10B Gene

Relevant External Links for TRMT10B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TRMT10B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRMT10B Gene

Publications for TRMT10B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 64
  2. A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase--extensive moonlighting in mitochondrial tRNA biogenesis. (PMID: 23042678) Vilardo E. … Rossmanith W. (Nucleic Acids Res. 2012) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3 64
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64

Products for TRMT10B Gene

Sources for TRMT10B Gene

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