TRMT10B Gene
protein-coding GIFtS: 37
GCID: GC09P037755
|
|
tRNA methyltransferase 10 homolog B (S. cerevisiae)(Previous name: RNA (guanine-9-) methyltransferase domain containing 3...)
(Previous symbol: RG9MTD3)
| |
Aliases
for TRMT10B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TRNA Methyltransferase 10 Homolog B (S. Cerevisiae)1 2 | | FLJ314551 | | RG9MTD31 2 3 | | RP11-3J10.92 | | BA3J10.91 | | TRNA Methyltransferase 10 Homolog B2 | | RNA (Guanine-9-) Methyltransferase Domain Containing 31 2 | | EC 2.1.1.-3 | | RNA (Guanine-9-)-Methyltransferase Domain-Containing Protein 32 3 | | |
Export aliases for TRMT10B gene to outside databasesPrevious GC identifer: GC09P037754 |
Summaries
for TRMT10B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TM10B_HUMAN, Q6PF06Function: Probable RNA methyltransferase (By similarity)
|
Genomic Views
for TRMT10B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TRMT10B
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRMT10B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRMT10B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p13.2 Ensembl cytogenetic band: 9p13.2 HGNC cytogenetic band: 9p13.1TRMT10B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P037755: view genomic region
(about GC identifiers)
Start:
|
37,753,802 bp from pter |
End:
|
37,778,969 bp from pter |
Size:
|
25,168 bases |
Orientation:
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plus strand |
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Proteins
for TRMT10B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM10B_HUMAN, Q6PF06 (See
protein sequence)Recommended Name: tRNA methyltransferase 10 homolog B Size: 316 amino acids; 36124 Da
Sequence caution: Sequence=BAB71074.1; Type=Erroneous termination; Positions=317; Note=Translated as stop;
Secondary accessions: Q05DJ4 Q5QP83 Q8NAG2 Q96N36Alternative splicing: 3 isoforms: Q6PF06-1 Q6PF06-2 Q6PF06-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TRMT10B: NX_Q6PF06
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6PF06
TRMT10B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_659401.2
ENSEMBL proteins: ENSP00000446050 ENSP00000445362 ENSP00000444612 ENSP00000437395 ENSP00000366983 ENSP00000297994 ENSP00000366982 ENSP00000444997
Human Recombinant Protein Products:
TRMT10B Antibody Products:
Assay Products for TRMT10B: |
Protein
Domains /
Families
for TRMT10B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRMT10B for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6PF06ProtoNet protein and cluster: Q6PF06 UniProtKB/Swiss-Prot: TM10B_HUMAN, Q6PF06Similarity: Belongs to the RNA methyltransferase TrmD family. TRM10 subfamily |
Function
for TRMT10B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TM10B_HUMAN, Q6PF06Function: Probable RNA methyltransferase (By similarity)Enzyme Number (IUBMB): EC 2.1.1.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT10B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT10B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT10B |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008168 | methyltransferase activity |
IEA | -- |
TRMT10B for ontologies About GeneDecksing
|
Pathways & Interactions
for TRMT10B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRMT10B
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for TRMT10B (ENSP000002979944) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TRMT10B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TRMT10B
Search CenterWatch for drugs/clinical trials and news about TRMT10B / TM10B
|
Transcripts
for TRMT10B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TRMT10B gene: NM_144964.2 Unigene Cluster for TRMT10B: TRNA methyltransferase 10 homolog B (S. cerevisiae) Hs.655614 [show with all ESTs]Unigene Representative Sequence: NM_1449649 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000540616 ENST00000538370 ENST00000537016 ENST00000488673 ENST00000377754
ENST00000297994(uc011lqo.2 uc004aai.3 uc004aaj.3 uc004aak.3)
ENST00000509577 ENST00000377753(uc011lqp.2 uc011lqq.2) ENST00000537911
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT10B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT10B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for TRMT10B | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRMT10B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRMT10B |
Additional cDNA sequence: AK056017.1 AK092718.1 AK294219.1 AK295733.1 AK304516.1 AK315922.1 BC012175.1 BC057774.1 12 DOTS entries: DT.95356515 DT.40297186 DT.70100884 DT.100680856 DT.209411 DT.95159287 DT.101976034 DT.121192829 DT.40111200 DT.95200346 DT.97806893 DT.97837068 24/70 AceView cDNA sequences (see all 70): AI279018 CK299949 BC057774 AI985517 CA774635 AI435297 BQ082433 AA320267 CA440955 BU735348 AA828484 BG472238 BC012175 BM820413 BX119672 AI914022 CB131149 AI927954 BX111785 BM792331 AA746199 AX747687 BQ880702 BU159604
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TRMT10B (see all 8) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | - | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TRMT10B
|
Expression
for TRMT10B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See TRMT10B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRMT10B
SOURCE GeneReport for Unigene cluster: Hs.655614
SABiosciences Custom PCR Arrays for TRMT10B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRMT10B
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat TRMT10B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRMT10B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRMT10B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT10B |
Orthologs
for TRMT10B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TRMT10B gene from 3/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
RG9MTD36 |
-- |
56(a) |
1 ↔ 1 |
GL343201.1(3817844-3830351) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.6162 |
Transcribed sequence with weak similarity to protein more |
73.08(n) |
|
137721223 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:1533411 |
zgc:153341 |
60.47(n)
58.1(a) |
|
768135 NM_001077281.1 NP_001070749.1 |
ENSEMBL Gene Tree for TRMT10B (if available)
TreeFam Gene Tree for TRMT10B (if available) |
Paralogs
for TRMT10B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TRMT10B gene
- TRMT10C2 TRMT10A2
TRMT10B for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TRMT10B
PGOHUM00000249775
|
Genomic Variants
for TRMT10B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TRMT10B (37753802 - 37778969 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TRMT10B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRMT10B |
|
Disorders
/ Diseases
for TRMT10B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TRMT10B for disorders About GeneDecksing
1  disease for TRMT10B: About MalaCardsmalaria
Export disorders for TRMT10B gene to outside databases
|
Publications
for TRMT10B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRMT10B gene integrated from 9 sources:
(articles sorted by number of sources associating them with TRMT10B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (2004)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TRMT10B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TRMT10B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRMT10B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TRMT10B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TRMT10B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TRMT10B gene:
Search GeneIP for patents involving TRMT10B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TRMT10B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TRMT10B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRMT10B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRMT10B | | | OriGene Protein Over-expression Lysate for TRMT10B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TRMT10B | | OriGene 3'-UTR Clone for TRMT10B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT10B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT10B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| |  |  |  |  | | | | |
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 |
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 | | | TRMT10B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT10B |
|  |  |  | | | | Search ThermoFisher Antibodies for TRMT10B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRMT10B |
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