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Aliases for TRMT10B Gene

Aliases for TRMT10B Gene

  • TRNA Methyltransferase 10B 2 3 5
  • RNA (Guanine-9-)-Methyltransferase Domain-Containing Protein 3 3 4
  • RNA (Guanine-9-) Methyltransferase Domain Containing 3 2 3
  • RG9MTD3 3 4
  • TRNA Methyltransferase 10 Homolog B (S. Cerevisiae) 2
  • EC 2.1.1.- 4
  • BA3J10.9 3

External Ids for TRMT10B Gene

Previous HGNC Symbols for TRMT10B Gene

  • RG9MTD3

Previous GeneCards Identifiers for TRMT10B Gene

  • GC09P037754
  • GC09P037755
  • GC09P037756
  • GC09P037757
  • GC09P037758
  • GC09P037759

Summaries for TRMT10B Gene

GeneCards Summary for TRMT10B Gene

TRMT10B (TRNA Methyltransferase 10B) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is TRMT10A.

UniProtKB/Swiss-Prot for TRMT10B Gene

  • Probable RNA methyltransferase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT10B Gene

Genomics for TRMT10B Gene

Regulatory Elements for TRMT10B Gene

Enhancers for TRMT10B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRMT10B on UCSC Golden Path with GeneCards custom track

Promoters for TRMT10B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRMT10B on UCSC Golden Path with GeneCards custom track

Genomic Location for TRMT10B Gene

Chromosome:
9
Start:
37,753,204 bp from pter
End:
37,778,972 bp from pter
Size:
25,769 bases
Orientation:
Plus strand

Genomic View for TRMT10B Gene

Genes around TRMT10B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRMT10B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRMT10B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT10B Gene

Proteins for TRMT10B Gene

  • Protein details for TRMT10B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PF06-TM10B_HUMAN
    Recommended name:
    tRNA methyltransferase 10 homolog B
    Protein Accession:
    Q6PF06
    Secondary Accessions:
    • B7Z216
    • B7Z3D3
    • Q05DJ4
    • Q5QP83
    • Q8NAG2
    • Q96N36

    Protein attributes for TRMT10B Gene

    Size:
    316 amino acids
    Molecular mass:
    36124 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71074.1; Type=Erroneous termination; Positions=317; Note=Translated as stop.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRMT10B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRMT10B Gene

Proteomics data for TRMT10B Gene at MOPED

Post-translational modifications for TRMT10B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for TRMT10B Gene

Domains & Families for TRMT10B Gene

Protein Domains for TRMT10B Gene

Graphical View of Domain Structure for InterPro Entry

Q6PF06

UniProtKB/Swiss-Prot:

TM10B_HUMAN :
  • Contains 1 SAM-dependent MTase TRM10-type domain.
  • Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.
Domain:
  • Contains 1 SAM-dependent MTase TRM10-type domain.
Family:
  • Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.
genes like me logo Genes that share domains with TRMT10B: view

No data available for Gene Families for TRMT10B Gene

Function for TRMT10B Gene

Molecular function for TRMT10B Gene

UniProtKB/Swiss-Prot Function:
Probable RNA methyltransferase.

Enzyme Numbers (IUBMB) for TRMT10B Gene

Phenotypes for TRMT10B Gene

GenomeRNAi human phenotypes for TRMT10B:
genes like me logo Genes that share phenotypes with TRMT10B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRMT10B Gene

Localization for TRMT10B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRMT10B Gene COMPARTMENTS Subcellular localization image for TRMT10B gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 2
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRMT10B Gene

Pathways & Interactions for TRMT10B Gene

SuperPathways for TRMT10B Gene

No Data Available

Interacting Proteins for TRMT10B Gene

Gene Ontology (GO) - Biological Process for TRMT10B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRMT10B Gene

Drugs & Compounds for TRMT10B Gene

No Compound Related Data Available

Transcripts for TRMT10B Gene

Unigene Clusters for TRMT10B Gene

TRNA methyltransferase 10 homolog B (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT10B Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - - -
SP5: - -
SP6: - - -
SP7: - -
SP8: -

Relevant External Links for TRMT10B Gene

GeneLoc Exon Structure for
TRMT10B
ECgene alternative splicing isoforms for
TRMT10B

Expression for TRMT10B Gene

mRNA expression in normal human tissues for TRMT10B Gene

SOURCE GeneReport for Unigene cluster for TRMT10B Gene Hs.655614

genes like me logo Genes that share expression patterns with TRMT10B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TRMT10B Gene

Orthologs for TRMT10B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRMT10B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRMT10B 35
  • 88.71 (n)
  • 85.76 (a)
TRMT10B 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRMT10B 35
  • 90.51 (n)
  • 87.34 (a)
TRMT10B 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trmt10b 35
  • 82.33 (n)
  • 78.41 (a)
Trmt10b 16
Trmt10b 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRMT10B 35
  • 99.89 (n)
  • 99.68 (a)
RG9MTD3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trmt10b 35
  • 81.1 (n)
  • 78.03 (a)
oppossum
(Monodelphis domestica)
Mammalia TRMT10B 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRMT10B 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC768672 35
  • 61.36 (n)
  • 59.47 (a)
TRMT10B 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRMT10B 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493764 35
  • 68.12 (n)
  • 69.93 (a)
Str.616 35
zebrafish
(Danio rerio)
Actinopterygii trmt10b 35
  • 60.47 (n)
  • 58.1 (a)
trmt10b 36
  • 50 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F25H8.1 36
  • 24 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM10 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToOne
Species with no ortholog for TRMT10B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRMT10B Gene

ENSEMBL:
Gene Tree for TRMT10B (if available)
TreeFam:
Gene Tree for TRMT10B (if available)

Paralogs for TRMT10B Gene

Paralogs for TRMT10B Gene

Pseudogenes.org Pseudogenes for TRMT10B Gene

genes like me logo Genes that share paralogs with TRMT10B: view

Variants for TRMT10B Gene

Sequence variations from dbSNP and Humsavar for TRMT10B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs36023446 - 37,770,720(-) CATCC(A/C/G)CAAGC nc-transcript-variant, reference, missense
rs12337034 - 37,776,286(+) GAAGG(C/T)GACAT nc-transcript-variant, reference, missense
rs725687 -- 37,755,887(+) GTTTA(A/G)GTAAA intron-variant
rs764224 -- 37,760,995(+) CACTT(C/T)TGAGG intron-variant
rs764225 -- 37,760,691(+) CACTA(G/T)AGGTG intron-variant

Variation tolerance for TRMT10B Gene

Residual Variation Intolerance Score: 46.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.34; 53.61% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TRMT10B Gene

Disorders for TRMT10B Gene

Relevant External Links for TRMT10B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRMT10B

No disorders were found for TRMT10B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRMT10B Gene

Publications for TRMT10B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 67
  2. A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase--extensive moonlighting in mitochondrial tRNA biogenesis. (PMID: 23042678) Vilardo E. … Rossmanith W. (Nucleic Acids Res. 2012) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for TRMT10B Gene

Sources for TRMT10B Gene

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