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Aliases for TRMT10A Gene

Aliases for TRMT10A Gene

  • TRNA Methyltransferase 10 Homolog A (S. Cerevisiae) 2 3
  • RNA (Guanine-9-)-Methyltransferase Domain-Containing Protein 2 3 4
  • RG9MTD2 3 4
  • RNA (Guanine-9-) Methyltransferase Domain Containing 2 2
  • TRNA Methyltransferase 10 Homolog A 3
  • Epididymis Secretory Protein Li 88 3
  • EC 2.1.1.- 4
  • HEL-S-88 3
  • MSSGM 3
  • TRM10 3

External Ids for TRMT10A Gene

Previous HGNC Symbols for TRMT10A Gene

  • RG9MTD2

Previous GeneCards Identifiers for TRMT10A Gene

  • GC04M100468

Summaries for TRMT10A Gene

Entrez Gene Summary for TRMT10A Gene

  • This gene encodes a protein that belongs to the tRNA (Guanine-1)-methyltransferase family. A similar gene in yeast modifies several different tRNA species. Mutations in this gene are associated with microcephaly, short stature, and impaired glucose metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

GeneCards Summary for TRMT10A Gene

TRMT10A (TRNA Methyltransferase 10 Homolog A (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with TRMT10A include microcephaly, short stature, and impaired glucose metabolism and primary microcephaly-mild intellectual disability-young-onset diabetes syndrome. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is TRMT10C.

UniProtKB/Swiss-Prot for TRMT10A Gene

  • RNA methyltransferase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT10A Gene

Genomics for TRMT10A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRMT10A Gene

99,546,707 bp from pter
99,564,032 bp from pter
17,326 bases
Minus strand

Genomic View for TRMT10A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRMT10A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT10A Gene

No data available for Regulatory Elements for TRMT10A Gene

Proteins for TRMT10A Gene

  • Protein details for TRMT10A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    tRNA methyltransferase 10 homolog A
    Protein Accession:
    Secondary Accessions:
    • B2R8X7
    • Q9Y2T9

    Protein attributes for TRMT10A Gene

    339 amino acids
    Molecular mass:
    39719 Da
    Quaternary structure:
    • Interacts with tRNA.

    Three dimensional structures from OCA and Proteopedia for TRMT10A Gene

neXtProt entry for TRMT10A Gene

Proteomics data for TRMT10A Gene at MOPED

Post-translational modifications for TRMT10A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRMT10A Gene

Antibody Products

No data available for DME Specific Peptides for TRMT10A Gene

Domains for TRMT10A Gene

Protein Domains for TRMT10A Gene

Graphical View of Domain Structure for InterPro Entry



  • Q8TBZ6
  • Contains 1 SAM-dependent MTase TRM10-type domain.
  • Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.
genes like me logo Genes that share domains with TRMT10A: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for TRMT10A Gene

Function for TRMT10A Gene

Molecular function for TRMT10A Gene

UniProtKB/Swiss-Prot Function:
RNA methyltransferase.

Enzyme Numbers (IUBMB) for TRMT10A Gene

Gene Ontology (GO) - Molecular Function for TRMT10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IDA 25053765
GO:0008168 methyltransferase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with TRMT10A: view

Phenotypes for TRMT10A Gene

MGI mutant phenotypes for TRMT10A:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with TRMT10A: view

Animal Model Products

CRISPR Products

miRNA for TRMT10A Gene

miRTarBase miRNAs that target TRMT10A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRMT10A

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TRMT10A Gene

Localization for TRMT10A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRMT10A Gene

Nucleus. Nucleus, nucleolus.

Gene Ontology (GO) - Cellular Components for TRMT10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 24204302
GO:0005730 nucleolus IDA 24204302
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TRMT10A: view

No data available for Subcellular locations from COMPARTMENTS for TRMT10A Gene

Pathways for TRMT10A Gene

SuperPathways for TRMT10A Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRMT10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process --
GO:0010960 magnesium ion homeostasis IEA --
GO:0030488 tRNA methylation IDA 25053765
GO:0032259 methylation --
genes like me logo Genes that share ontologies with TRMT10A: view

No data available for Pathways by source for TRMT10A Gene

Transcripts for TRMT10A Gene

Unigene Clusters for TRMT10A Gene

TRNA methyltransferase 10 homolog A (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRMT10A

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT10A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8
SP3: -
SP4: - -
SP5: -

Relevant External Links for TRMT10A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRMT10A Gene

mRNA expression in normal human tissues for TRMT10A Gene

Protein differential expression in normal tissues for TRMT10A Gene

This gene is overexpressed in Lung (25.0), Fetal ovary (16.2), Peripheral blood mononuclear cells (16.2), and Lymph node (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRMT10A Gene

SOURCE GeneReport for Unigene cluster for TRMT10A Gene Hs.380412

mRNA Expression by UniProt/SwissProt for TRMT10A Gene

Tissue specificity: Expressed in embryonic and fetal brain. It is expressed throughout the dorsal telencephalon at 8 and 11 weeks of gestation, with highest expression in ventricular zone and marginal zone. Detected in cerebellar cortex and nuclei, but not in dorsal telencephalon, at later stages.
genes like me logo Genes that share expressions with TRMT10A: view

Expression partners for TRMT10A Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TRMT10A Gene

Orthologs for TRMT10A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRMT10A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRMT10A 35
  • 89.02 (n)
  • 86.94 (a)
TRMT10A 36
  • 86 (a)
(Canis familiaris)
Mammalia TRMT10A 35
  • 90.43 (n)
  • 89.64 (a)
TRMT10A 36
  • 87 (a)
(Mus musculus)
Mammalia Trmt10a 35
  • 81.22 (n)
  • 78.64 (a)
Trmt10a 16
Trmt10a 36
  • 76 (a)
(Pan troglodytes)
Mammalia TRMT10A 35
  • 99.8 (n)
  • 99.71 (a)
RG9MTD2 36
  • 93 (a)
(Rattus norvegicus)
Mammalia Trmt10a 35
  • 80.04 (n)
  • 75.45 (a)
(Monodelphis domestica)
Mammalia TRMT10A 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia TRMT10A 36
  • 49 (a)
(Gallus gallus)
Aves TRMT10A 35
  • 75.69 (n)
  • 78.82 (a)
TRMT10A 36
  • 67 (a)
(Anolis carolinensis)
Reptilia TRMT10A 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6891 35
trmt10a 35
  • 67.72 (n)
  • 70.28 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15028 35
(Danio rerio)
Actinopterygii LOC560222 35
  • 64.58 (n)
  • 66.55 (a)
TRMT10A 36
  • 56 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7744 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000324 35
  • 45.44 (n)
  • 39.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14618 35
  • 43.51 (n)
  • 37.66 (a)
CG14618 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea F25H8.1 35
  • 53.48 (n)
  • 42.78 (a)
F25H8.1 36
  • 31 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR110C 35
  • 48.13 (n)
  • 39.8 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C03740g 35
  • 48.06 (n)
  • 35.27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM10 35
  • 45.16 (n)
  • 33.96 (a)
TRM10 36
  • 27 (a)
TRM10 38
bread mold
(Neurospora crassa)
Ascomycetes NCU02231 35
  • 46.67 (n)
  • 37.42 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes trm10 35
  • 51.63 (n)
  • 41.96 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7762 36
  • 36 (a)
Species with no ortholog for TRMT10A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRMT10A Gene

Gene Tree for TRMT10A (if available)
Gene Tree for TRMT10A (if available)

Paralogs for TRMT10A Gene

Paralogs for TRMT10A Gene

genes like me logo Genes that share paralogs with TRMT10A: view

Variants for TRMT10A Gene

Sequence variations from dbSNP and Humsavar for TRMT10A Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1054730 -- 99,548,975(-) TTTTT(A/G)AAAAC utr-variant-3-prime
rs1491233 -- 99,554,903(-) ATGCA(A/G)TCAAT intron-variant
rs1491234 -- 99,554,716(-) AAACG(C/T)AGTCG intron-variant
rs1491235 -- 99,546,722(-) ATAAA(C/T)GCATC utr-variant-3-prime, downstream-variant-500B
rs3817083 -- 99,557,467(-) AGAAT(A/G)GCCAT intron-variant

Relevant External Links for TRMT10A Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TRMT10A Gene

Disorders for TRMT10A Gene


  • Microcephaly, short stature, and impaired glucose metabolism (MSSGM) [MIM:616033]: A disease characterized by microcephaly, mental retardation, short stature, and disturbed glucose metabolism. Additional clinical features include delayed puberty, hypoglycemia-related seizures, hyperinsulinemic hypoglycemia, and early-onset diabetes. {ECO:0000269 PubMed:24204302, ECO:0000269 PubMed:25053765}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with TRMT10A: view

No data available for OMIM , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TRMT10A Gene

Publications for TRMT10A Gene

  1. tRNA methyltransferase homolog gene TRMT10A mutation in young onset diabetes and primary microcephaly in humans. (PMID: 24204302) Igoillo-Esteve M. … Cnop M. (PLoS Genet. 2013) 2 3 4
  2. TRMT10A dysfunction is associated with abnormalities in glucose homeostasis, short stature and microcephaly. (PMID: 25053765) Gillis D. … Elpeleg O. (J. Med. Genet. 2014) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjoeblom T. … Velculescu V.E. (Science 2006) 4

Products for TRMT10A Gene

Sources for TRMT10A Gene

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