TRMT10A Gene
protein-coding GIFtS: 38
GCID: GC04M100468
|
|
tRNA methyltransferase 10 homolog A (S. cerevisiae)(Previous name: RNA (guanine-9-) methyltransferase domain containing 2...)
(Previous symbol: RG9MTD2)
| |
Aliases
for TRMT10A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TRNA Methyltransferase 10 Homolog A (S. Cerevisiae)1 2 | | RNA (Guanine-9-)-Methyltransferase Domain-Containing Protein 22 3 | | RG9MTD21 2 3 | | MGC270341 | | TRM101 2 | | TRNA Methyltransferase 10 Homolog A2 | | RNA (Guanine-9-) Methyltransferase Domain Containing 21 2 | | EC 2.1.1.-3 |
Export aliases for TRMT10A gene to outside databases |
Summaries
for TRMT10A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TM10A_HUMAN, Q8TBZ6Function: Probable RNA methyltransferase (By similarity)
|
Genomic Views
for TRMT10A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TRMT10A
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRMT10A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRMT10A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q23 Ensembl cytogenetic band: 4q23 HGNC cytogenetic band: 4q23TRMT10A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M100468: view genomic region
(about GC identifiers)
Start:
|
100,467,864 bp from pter |
End:
|
100,485,189 bp from pter |
Size:
|
17,326 bases |
Orientation:
|
minus strand |
|
Proteins
for TRMT10A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM10A_HUMAN, Q8TBZ6 (See
protein sequence)Recommended Name: tRNA methyltransferase 10 homolog A Size: 339 amino acids; 39719 Da
1 PDB 3D structure from  and Proteopedia  for TRMT10A:4FMW (3D)
Secondary accessions: B2R8X7 Q9Y2T9Explore the universe of human proteins at neXtProt for TRMT10A: NX_Q8TBZ6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TBZ6
TRMT10A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001128137.1 NP_001128138.1 NP_689505.1
ENSEMBL proteins: ENSP00000378343 ENSP00000273962 ENSP00000378342 ENSP00000397551 ENSP00000423628
Human Recombinant Protein Products:
TRMT10A Antibody Products:
Assay Products for TRMT10A: |
Protein
Domains /
Families
for TRMT10A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRMT10A for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8TBZ6ProtoNet protein and cluster: Q8TBZ6 UniProtKB/Swiss-Prot: TM10A_HUMAN, Q8TBZ6Similarity: Belongs to the RNA methyltransferase TrmD family. TRM10 subfamily |
Function
for TRMT10A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TM10A_HUMAN, Q8TBZ6Function: Probable RNA methyltransferase (By similarity)Enzyme Number (IUBMB): EC 2.1.1.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT10A (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT10A (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for TRMT10A | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRMT10A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRMT10A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT10A |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008168 | methyltransferase activity |
IEA | -- |
TRMT10A for ontologies About GeneDecksing
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Trmt10a):
TRMT10A for phenotypes About GeneDecksing
|
Pathways & Interactions
for TRMT10A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRMT10A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/26 Interacting proteins for TRMT10A (Q8TBZ63 ENSP000002739624) via UniProtKB, MINT, STRING, and/or I2D (see all 26)About this table
|
Drugs & Compounds
for TRMT10A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TRMT10A
Search CenterWatch for drugs/clinical trials and news about TRMT10A / TM10A
|
Transcripts
for TRMT10A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TRMT10A gene (3 alternative transcripts): NM_001134665.1 NM_001134666.1 NM_152292.4 Unigene Cluster for TRMT10A: TRNA methyltransferase 10 homolog A (S. cerevisiae) Hs.380412 [show with all ESTs]Unigene Representative Sequence: NM_1522927 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000394877(uc003huz.4 uc003hva.4) ENST00000273962(uc003huy.3)
ENST00000394876 ENST00000455368 ENST00000514547 ENST00000515831 ENST00000507394
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT10A (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT10A (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for TRMT10A | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRMT10A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRMT10A |
Additional cDNA sequence: AF106046.1 AK000332.1 AK313548.1 BC028373.2 7 DOTS entries: DT.102825271 DT.108302 DT.92424319 DT.92032782 DT.97818017 DT.100702267 DT.86836828 24/93 AceView cDNA sequences (see all 93): BQ000156 AA330454 AI627530 AA987337 AA983872 BQ721850 NM_152292 BE671949 CR598836 BC028373 AA305933 AA329639 AI372956 AW594250 AI167459 BM464705 CR623954 CR598027 AA252654 AA434121 BF433159 BF055440 AF106046 BX500677
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for TRMT10A About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TRMT10A
|
Expression
for TRMT10A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See TRMT10A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRMT10A
SOURCE GeneReport for Unigene cluster: Hs.380412
SABiosciences Custom PCR Arrays for TRMT10A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRMT10A
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat TRMT10A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRMT10A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRMT10A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT10A |
Orthologs
for TRMT10A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TRMT10A gene from 10/33 species (see all 33) About this table
ENSEMBL Gene Tree for TRMT10A (if available)
TreeFam Gene Tree for TRMT10A (if available) |
Paralogs
for TRMT10A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TRMT10A gene
- TRMT10C2 TRMT10B2
TRMT10A for paralogs About GeneDecksing
|
Genomic Variants
for TRMT10A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRMT10A |
|
Disorders
/ Diseases
for TRMT10A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TRMT10A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRMT10A gene integrated from 9 sources:
(articles sorted by number of sources associating them with TRMT10A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
|
External Searches for TRMT10A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TRMT10A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRMT10A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TRMT10A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TRMT10A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TRMT10A gene:
Search GeneIP for patents involving TRMT10A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TRMT10A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TRMT10A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRMT10A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRMT10A | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for TRMT10A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT10A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRMT10A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TRMT10A | | OriGene Custom Protein Services for TRMT10A | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRMT10A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRMT10A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRMT10A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRMT10A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRMT10A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRMT10A |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TRMT10A |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | TRMT10A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT10A |
|  |  |  | | | | Search ThermoFisher Antibodies for TRMT10A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRMT10A |
|
|
|
|
