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Aliases for TRMT1 Gene

Aliases for TRMT1 Gene

  • TRNA Methyltransferase 1 Homolog (S. Cerevisiae) 2 3
  • TRNA 2,2-Dimethylguanosine-26 Methyltransferase 3 4
  • TRNA(Guanine-26,N(2)-N(2)) Methyltransferase 3 4
  • TRNA(M(2,2)G26)Dimethyltransferase 3 4
  • TRM1 3 6
  • N(2),N(2)-Dimethylguanosine TRNA Methyltransferase 3
  • TRNA (Guanine(26)-N(2))-Dimethyltransferase 3
  • TRM1 TRNA Methyltransferase 1 Homolog 3
  • EC 2.1.1.216 4
  • EC 2.1.1.32 63

External Ids for TRMT1 Gene

Previous GeneCards Identifiers for TRMT1 Gene

  • GC22P044944
  • GC22P045052
  • GC19M013077
  • GC19M013215
  • GC19M012788

Summaries for TRMT1 Gene

GeneCards Summary for TRMT1 Gene

TRMT1 (TRNA Methyltransferase 1 Homolog (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include tRNA binding and tRNA (guanine-N2-)-methyltransferase activity. An important paralog of this gene is TRMT1L.

UniProtKB/Swiss-Prot for TRMT1 Gene

  • Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT1 Gene

Genomics for TRMT1 Gene

Regulatory Elements for TRMT1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRMT1 Gene

Start:
13,104,900 bp from pter
End:
13,117,567 bp from pter
Size:
12,668 bases
Orientation:
Minus strand

Genomic View for TRMT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRMT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT1 Gene

Proteins for TRMT1 Gene

  • Protein details for TRMT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXH9-TRM1_HUMAN
    Recommended name:
    tRNA (guanine(26)-N(2))-dimethyltransferase
    Protein Accession:
    Q9NXH9
    Secondary Accessions:
    • O76103
    • Q548Y5
    • Q8WVA6

    Protein attributes for TRMT1 Gene

    Size:
    659 amino acids
    Molecular mass:
    72234 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRMT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRMT1 Gene

Proteomics data for TRMT1 Gene at MOPED

Selected DME Specific Peptides for TRMT1 Gene

Post-translational modifications for TRMT1 Gene

  • Ubiquitination at Lys371 and Lys487
  • Modification sites at PhosphoSitePlus

Domains for TRMT1 Gene

Suggested Antigen Peptide Sequences for TRMT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NXH9

UniProtKB/Swiss-Prot:

TRM1_HUMAN :
  • Q9NXH9
Domain:
  • Contains 1 Trm1 methyltransferase domain.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
Similarity:
  • Contains 1 C3H1-type zinc finger.
genes like me logo Genes that share domains with TRMT1: view

No data available for Gene Families for TRMT1 Gene

Function for TRMT1 Gene

Molecular function for TRMT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: 2 S-adenosyl-L-methionine + guanine(26) in tRNA = 2 S-adenosyl-L-homocysteine + N(2)-dimethylguanine(26) in tRNA.
UniProtKB/Swiss-Prot Function: Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups

Enzyme Numbers (IUBMB) for TRMT1 Gene

Gene Ontology (GO) - Molecular Function for TRMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IEA --
GO:0003723 RNA binding --
GO:0004809 tRNA (guanine-N2-)-methyltransferase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with TRMT1: view

Phenotypes for TRMT1 Gene

genes like me logo Genes that share phenotypes with TRMT1: view

Animal Model Products

CRISPR Products

miRNA for TRMT1 Gene

miRTarBase miRNAs that target TRMT1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TRMT1 Gene

Localization for TRMT1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRMT1 Gene COMPARTMENTS Subcellular localization image for TRMT1 gene
Compartment Confidence
mitochondrion 3
cytosol 2
chloroplast 1
nucleus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRMT1 Gene

Pathways for TRMT1 Gene

SuperPathways for TRMT1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008033 tRNA processing --
GO:0030488 tRNA methylation IEA --
genes like me logo Genes that share ontologies with TRMT1: view

No data available for Pathways by source for TRMT1 Gene

Compounds for TRMT1 Gene

(2) HMDB Compounds for TRMT1 Gene

Compound Synonyms Cas Number PubMed IDs
S-Adenosylhomocysteine
  • (S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine
979-92-0
S-Adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
29908-03-0
genes like me logo Genes that share compounds with TRMT1: view

Transcripts for TRMT1 Gene

Unigene Clusters for TRMT1 Gene

TRNA methyltransferase 1 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRMT1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ·
SP1: - - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - - - - - - - - - - - -
SP5:
SP6: - - - - - - - -
SP7: - - - - - -
SP8: - - - - - - -
SP9: - - - - -
SP10:
SP11:
SP12: - - - - - - - - -
SP13:
SP14: - - - - -
SP15: - - - - - - - -
SP16: - - - - - - - - - - -
SP17: - - -
SP18:
SP19: - - - -
SP20: - - - - -
SP21: - - - -
SP22: - - - - - -
SP23: - - - - - - - - -
SP24: - -
SP25: - - -

ExUns: 7c · 7d ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18
SP1:
SP2:
SP3: -
SP4:
SP5: -
SP6:
SP7: - -
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13: -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:

Relevant External Links for TRMT1 Gene

GeneLoc Exon Structure for
TRMT1
ECgene alternative splicing isoforms for
TRMT1

Expression for TRMT1 Gene

mRNA expression in normal human tissues for TRMT1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRMT1 Gene

SOURCE GeneReport for Unigene cluster for TRMT1 Gene Hs.515169

genes like me logo Genes that share expressions with TRMT1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRMT1 Gene

Orthologs for TRMT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRMT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRMT1 35
  • 99.44 (n)
  • 99.54 (a)
TRMT1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRMT1 35
  • 87.46 (n)
  • 88.07 (a)
TRMT1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRMT1 35
  • 87.63 (n)
  • 90.41 (a)
TRMT1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trmt1 35
  • 81.58 (n)
  • 84.62 (a)
Trmt1 16
Trmt1 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRMT1 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRMT1 36
  • 43 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trmt1 35
  • 83.33 (n)
  • 86.81 (a)
lizard
(Anolis carolinensis)
Reptilia TRMT1 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trmt1 35
  • 66.26 (n)
  • 69.66 (a)
zebrafish
(Danio rerio)
Actinopterygii trmt1 35
  • 65.07 (n)
  • 68.86 (a)
trmt1 36
  • 56 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009740 35
  • 55.46 (n)
  • 51.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6388 35
  • 54.5 (n)
  • 50 (a)
CG6388 36
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea trm-1 35
  • 46.91 (n)
  • 44.4 (a)
trm-1 36
  • 39 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR075W 35
  • 47.88 (n)
  • 39.84 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM1 35
  • 45.81 (n)
  • 40.4 (a)
TRM1 36
  • 34 (a)
OneToMany
TRM1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F19404g 35
  • 45.48 (n)
  • 37.62 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G15810 35
  • 49.14 (n)
  • 43.25 (a)
rice
(Oryza sativa)
Liliopsida Os.14753 35
Os03g0786700 35
  • 50.5 (n)
  • 44.51 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06336 35
  • 47.91 (n)
  • 40.98 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes trm1 35
  • 46.86 (n)
  • 44.31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6910 36
  • 46 (a)
OneToMany
Species with no ortholog for TRMT1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRMT1 Gene

ENSEMBL:
Gene Tree for TRMT1 (if available)
TreeFam:
Gene Tree for TRMT1 (if available)

Paralogs for TRMT1 Gene

Paralogs for TRMT1 Gene

Pseudogenes.org Pseudogenes for TRMT1 Gene

genes like me logo Genes that share paralogs with TRMT1: view

Variants for TRMT1 Gene

Sequence variations from dbSNP and Humsavar for TRMT1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1057291 -- 13,105,318(+) TGGGC(A/C)ACATC reference, synonymous-codon
rs2240659 -- 13,111,024(+) ACAGC(A/G)TTTCC intron-variant
rs3815340 -- 13,105,675(+) CCCAC(A/C)GGGCC intron-variant
rs7256309 -- 13,106,883(+) agtgg(C/T)gctat intron-variant
rs7256409 -- 13,106,891(+) tatct(C/T)ggctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRMT1 Gene

Variant ID Type Subtype PubMed ID
nsv911082 CNV Loss 21882294
nsv911086 CNV Loss 21882294
nsv911087 CNV Loss 21882294
dgv3735n71 CNV Loss 21882294
nsv911090 CNV Loss 21882294
dgv3736n71 CNV Loss 21882294

Relevant External Links for TRMT1 Gene

HapMap Linkage Disequilibrium report
TRMT1
Human Gene Mutation Database (HGMD)
TRMT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRMT1 Gene

Disorders for TRMT1 Gene

No disorders were found for TRMT1 Gene.

No data available for UniProtKB/Swiss-Prot for TRMT1 Gene

Publications for TRMT1 Gene

  1. The human tRNA(m22G26)dimethyltransferase: functional expression and characterization of a cloned hTRM1 gene. (PMID: 10982862) Liu J. … Straby K.B. (Nucleic Acids Res. 2000) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4

Products for TRMT1 Gene

Sources for TRMT1 Gene

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