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TRMT1 Gene

protein-coding   GIFtS: 53
GCID: GC19M013215

TRNA Methyltransferase 1 Homolog (S. Cerevisiae)

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TRNA Methyltransferase 1 Homolog (S. Cerevisiae)1 2     N(2),N(2)-Dimethylguanosine TRNA Methyltransferase2
tRNA(m(2,2)G26)dimethyltransferase2 3     TRM1 TRNA Methyltransferase 1 Homolog2
TRNA 2,2-Dimethylguanosine-26 Methyltransferase2 3     TRNA (Guanine(26)-N(2))-Dimethyltransferase2
TRNA(Guanine-26,N(2)-N(2)) Methyltransferase2 3     EC 2.1.1.2163
TRM12 5     EC 2.1.1.328

External Ids:    HGNC: 259801   Entrez Gene: 556212   Ensembl: ENSG000001049077   OMIM: 6116695   UniProtKB: Q9NXH93   

Export aliases for TRMT1 gene to outside databases

Previous GC identifers: GC22P044944 GC22P045052 GC19M013077 GC19M012788


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TRMT1 Gene:
TRMT1 (tRNA methyltransferase 1 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with TRMT1 include malaria. GO annotations related to this gene include tRNA binding and tRNA (guanine-N2-)-methyltransferase activity. An important paralog of this gene is TRMT1L.

UniProtKB/Swiss-Prot: TRM1_HUMAN, Q9NXH9
Function: Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as
donor of the methyl groups




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRMT1 gene promoter:
         AREB6   Pbx1a   c-Myb   En-1   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRMT1 promoter sequence
   Search Chromatin IP Primers for TRMT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRMT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.13

TRMT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRMT1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M013215:  view genomic region     (about GC identifiers)

Start:
13,215,714 bp from pter      End:
13,228,381 bp from pter
Size:
12,668 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRM1_HUMAN, Q9NXH9 (See protein sequence)
Recommended Name: tRNA (guanine(26)-N(2))-dimethyltransferase  
Size: 659 amino acids; 72234 Da
Secondary accessions: O76103 Q548Y5 Q8WVA6
Alternative splicing: 2 isoforms:  Q9NXH9-1   Q9NXH9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRMT1: NX_Q9NXH9

Explore proteomics data for TRMT1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys371, Lys487
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for TRMT1 (Q9NXH9)
     DFYVRVFV  VFYNPVQEFNRDL 


    See TRMT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001129507.1  NP_001136026.1  NP_060192.1  

    ENSEMBL proteins: 
     ENSP00000221504   ENSP00000466967   ENSP00000465370   ENSP00000467938   ENSP00000466716  
     ENSP00000466966   ENSP00000468031   ENSP00000468377   ENSP00000467984   ENSP00000350352  
     ENSP00000416149  

    TRMT1 Human Recombinant Protein Products:

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    Novus Biologicals TRMT1 Protein
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    Cloud-Clone Corp. Proteins for TRMT1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000571 Znf_CCCH
     IPR002905 Trm1

    Graphical View of Domain Structure for InterPro Entry Q9NXH9

    ProtoNet protein and cluster: Q9NXH9

    2 Blocks protein domains:
    IPB000571 Zn-finger
    IPB002905 N2,N2-dimethylguanosine tRNA methyltransferase


    UniProtKB/Swiss-Prot: TRM1_HUMAN, Q9NXH9
    Similarity: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family
    Similarity: Contains 1 C3H1-type zinc finger
    Similarity: Contains 1 Trm1 methyltransferase domain


    TRMT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRM1_HUMAN, Q9NXH9
    Function: Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as
    donor of the methyl groups
    Catalytic activity: 2 S-adenosyl-L-methionine + guanine(26) in tRNA = 2 S-adenosyl-L-homocysteine +
    N(2)-dimethylguanine(26) in tRNA

         Enzyme Numbers (IUBMB): EC 2.1.1.322 EC 2.1.1.2161

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000049tRNA binding IEA--
    GO:0003723RNA binding ----
    GO:0004809tRNA (guanine-N2-)-methyltransferase activity IEA--
    GO:0016740transferase activity ----
    GO:0044822poly(A) RNA binding IDA--
         
    TRMT1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TRMT1:
     Increased TP53 protein express 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRMT1
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    miRNA
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    miRTarBase miRNAs that target TRMT1:
    hsa-mir-16-5p (MIRT031488), hsa-let-7b-5p (MIRT001584), hsa-mir-155-5p (MIRT020603)

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3
    cytosol2
    chloroplast1
    nucleus1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRMT1
    Interactions:

        Search GeneGlobe Interaction Network for TRMT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRMT1 (Q9NXH92, 3 ENSP000003503524) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAGEA11P433642, 3, ENSP000003473584MINT-67392 I2D: score=6 STRING: ENSP00000347358
    OSGEPQ9NPF43, ENSP000002065424I2D: score=1 STRING: ENSP00000206542
    PUS1Q9Y6063, ENSP000003658374I2D: score=1 STRING: ENSP00000365837
    SEH1LQ96EE33, ENSP000003827794I2D: score=1 STRING: ENSP00000382779
    TRMT10AQ8TBZ63, ENSP000002739624I2D: score=1 STRING: ENSP00000273962
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008033tRNA processing ----

    TRMT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRMT1 (TRM1)

    2 HMDB Compounds for TRMT1    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TRMT1 gene (3 alternative transcripts): 
    NM_001136035.2  NM_001142554.1  NM_017722.3  

    Unigene Cluster for TRMT1:

    TRNA methyltransferase 1 homolog (S. cerevisiae)
    Hs.515169  [show with all ESTs]
    Unigene Representative Sequence: AL390133
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000221504(uc002mwk.2) ENST00000593157 ENST00000592062 ENST00000588511
    ENST00000585435 ENST00000586830 ENST00000587487 ENST00000592814 ENST00000587633
    ENST00000593257 ENST00000591717 ENST00000588813 ENST00000591425 ENST00000592729
    ENST00000588746 ENST00000586224 ENST00000592892 ENST00000585622
    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TRMT1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRMT1
      QuantiTect SYBR Green Assays in human, mouse, rat TRMT1
      QuantiFast Probe-based Assays in human, mouse, rat TRMT1

    Additional mRNA sequence: 

    AF075055.1 AF196479.1 AK000251.1 AK292377.1 AK304636.1 AL390133.1 BC002492.2 BC018302.1 
    BC034242.1 BC040126.1 

    16 DOTS entries:

    DT.97847321  DT.92331801  DT.100800983  DT.100027965  DT.100814526  DT.100814536  DT.92451444  DT.121499054 
    DT.100814530  DT.100814539  DT.121499069  DT.100814541  DT.121499060  DT.97769462  DT.100810652  DT.121499077 

    Selected AceView cDNA sequences (see all 267):

    BU735944 BI871710 BM454658 AW404364 BC018302 BC034242 BM834458 BQ063194 
    BQ212049 BG761647 AU280636 NM_017722 BQ224966 BI763320 BU683297 CB850540 
    CR618815 BQ217923 AI498715 BM976240 BG236003 BM693880 CB144287 CD676376 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TRMT1 (see all 25)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ·
    SP1:                          -     -                             -     -                 -     -                                                               
    SP2:                                                              -     -                 -     -                                                               
    SP3:                                                              -     -                 -     -                                                               
    SP4:                          -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                                             
    SP5:                                                                                                                                                            

    ExUns: 7c · 7d ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18
    SP1:                                                                                                            
    SP2:                                                                                                            
    SP3:                                      -                                                                     
    SP4:                                                                                                            
    SP5:        -                                                                                                   


    ECgene alternative splicing isoforms for TRMT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRMT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGTTGCTGGG
    TRMT1 Expression
    About this image

    TRMT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRMT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515169
        Custom PCR Arrays for TRMT1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRMT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TRMT1 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trmt11 , 5 TRM1 tRNA methyltransferase 1 homolog (S. cerevisiae)5
    tRNA methyltransferase 11
    81.58(n)1
    84.62(a)1
      8 (41.02 cM)5
    2125281  NM_198020.21  NP_932137.21 
     846863075 
    lizard
    (Anolis carolinensis)
    Reptilia TRMT16
    tRNA methyltransferase 1 homolog (S. cerevisiae)
    65(a)
    1 ↔ 1
    GL343286.1(600869-627684)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ061437.12   -- 77.58(n)    BJ061437.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CD599744.12   -- 76.09(n)    CD599744.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG63881 CG6388 54.5(n)
    50(a)
      34656  NM_135722.4  NP_609566.1 
    worm
    (Caenorhabditis elegans)
    Secernentea trm-11 trm-1 46.91(n)
    44.4(a)
      179920  NM_074112.5  NP_506513.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TRM1(YDR120C)4
    TRM11
    tRNA methyltransferase; two forms of the protein are more4
    TRM11
    45.81(n)1
    40.4(a)1
      4(693261-691549)4
    8516981, 4  NP_010405.31  NP_010405.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G158101 AT5G15810 49.14(n)
    43.25(a)
      831438  NM_121586.2  NP_197085.2 
    rice
    (Oryza sativa)
    Liliopsida Os.147532 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.16(n)    AK067936.1 


    ENSEMBL Gene Tree for TRMT1 (if available)
    TreeFam Gene Tree for TRMT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRMT1 gene
    TRMT1L2  

    TRMT1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TRMT1
    PGOHUM00000242060


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRMT1 (see all 338)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1405615571,2
    --13216005(+) CAGCTC/TCCCCA 3 -- int10--------
    rs1427868691,2
    C--13216066(+) AAAGGG/TAGGAG 3 -- int11Minor allele frequency- T:0.00EU 1317
    rs340115701,2
    C--13216091(+) TAAACA/CTCTTG 6 R M mis10--------
    rs1508320901,2
    C,F--13216115(+) TGAGCC/TGGGCA 6 Q R mis11Minor allele frequency- T:0.01NA 4542
    rs2018734171,2
    --13216125(+) AGCCCG/TCTGGG 6 R syn10--------
    rs1398395451,2
    C,F--13216130(+) GCTGGG/CCCACA 6 /A /G mis11Minor allele frequency- C:0.00NA 4550
    rs1511192041,2
    C,F--13216136(+) CCACAT/CCTTCC 6 /D /G mis12Minor allele frequency- C:0.00NA EU 5869
    rs2011113211,2
    --13216144(+) TCCGGC/TGGCTC 6 P syn10--------
    rs1410724631,2
    C,F--13216147(+) GGCGGC/TTCCTT 6 E syn12Minor allele frequency- T:0.00NA EU 5871
    rs2004953601,2
    --13216164(+) GTTCTC/GAAGCA 6 Q E mis10--------

    HapMap Linkage Disequilibrium report for TRMT1 (13215714 - 13228381 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TRMT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911082CNV Loss21882294
    dgv3736n71CNV Loss21882294
    dgv3735n71CNV Loss21882294
    nsv911087CNV Loss21882294
    nsv911086CNV Loss21882294
    nsv911090CNV Loss21882294

    Human Gene Mutation Database (HGMD): TRMT1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRMT1
    DNA2.0 Custom Variant and Variant Library Synthesis for TRMT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611669    OMIM disorders: --

    1 disease for TRMT1:    
    About MalaCards
    malaria


    TRMT1 for disorders           About GeneDecksing


    Export disorders for TRMT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRMT1 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with TRMT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human tRNA(m22G26)dimethyltransferase: functional expression and characterization of a cloned hTRM1 gene. (PubMed id 10982862)1, 2, 3 Liu J. and Straby K.B. (Nucleic Acids Res. 2000)
    2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55621 HGNC: 25980 AceView: FLJ20244 Ensembl:ENSG00000104907 euGenes: HUgn55621
    ECgene: TRMT1 H-InvDB: TRMT1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRMT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRMT1 gene:
    Search GeneIP for patents involving TRMT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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