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Aliases for TRMT1 Gene

Aliases for TRMT1 Gene

  • TRNA Methyltransferase 1 2 3
  • TRNA 2,2-Dimethylguanosine-26 Methyltransferase 3 4
  • TRNA(Guanine-26,N(2)-N(2)) Methyltransferase 3 4
  • TRNA(M(2,2)G26)Dimethyltransferase 3 4
  • N(2),N(2)-Dimethylguanosine TRNA Methyltransferase 3
  • TRNA Methyltransferase 1 Homolog (S. Cerevisiae) 2
  • TRM1 TRNA Methyltransferase 1 Homolog 3
  • TRNA Methyltransferase 1 Homolog 3
  • EC 2.1.1.216 4
  • EC 2.1.1.32 63
  • TRM1 3

External Ids for TRMT1 Gene

Previous GeneCards Identifiers for TRMT1 Gene

  • GC22P044944
  • GC22P045052
  • GC19M013077
  • GC19M013215
  • GC19M012788

Summaries for TRMT1 Gene

GeneCards Summary for TRMT1 Gene

TRMT1 (TRNA Methyltransferase 1) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA modification in the nucleus and cytosol. GO annotations related to this gene include poly(A) RNA binding and tRNA binding. An important paralog of this gene is TRMT1L.

UniProtKB/Swiss-Prot for TRMT1 Gene

  • Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT1 Gene

Genomics for TRMT1 Gene

Regulatory Elements for TRMT1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRMT1 Gene

Chromosome:
19
Start:
13,104,900 bp from pter
End:
13,117,567 bp from pter
Size:
12,668 bases
Orientation:
Minus strand

Genomic View for TRMT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRMT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT1 Gene

Proteins for TRMT1 Gene

  • Protein details for TRMT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXH9-TRM1_HUMAN
    Recommended name:
    tRNA (guanine(26)-N(2))-dimethyltransferase
    Protein Accession:
    Q9NXH9
    Secondary Accessions:
    • O76103
    • Q548Y5
    • Q8WVA6

    Protein attributes for TRMT1 Gene

    Size:
    659 amino acids
    Molecular mass:
    72234 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRMT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRMT1 Gene

Proteomics data for TRMT1 Gene at MOPED

Selected DME Specific Peptides for TRMT1 Gene

Post-translational modifications for TRMT1 Gene

  • Ubiquitination at Lys 371 and Lys 487
  • Modification sites at PhosphoSitePlus

Domains & Families for TRMT1 Gene

Suggested Antigen Peptide Sequences for TRMT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NXH9

UniProtKB/Swiss-Prot:

TRM1_HUMAN :
  • Contains 1 Trm1 methyltransferase domain.
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
  • Contains 1 C3H1-type zinc finger.
Domain:
  • Contains 1 Trm1 methyltransferase domain.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
Similarity:
  • Contains 1 C3H1-type zinc finger.
genes like me logo Genes that share domains with TRMT1: view

No data available for Gene Families for TRMT1 Gene

Function for TRMT1 Gene

Molecular function for TRMT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2 S-adenosyl-L-methionine + guanine(26) in tRNA = 2 S-adenosyl-L-homocysteine + N(2)-dimethylguanine(26) in tRNA.
UniProtKB/Swiss-Prot Function:
Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups

Enzyme Numbers (IUBMB) for TRMT1 Gene

Gene Ontology (GO) - Molecular Function for TRMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IEA --
GO:0003723 RNA binding --
GO:0004809 tRNA (guanine-N2-)-methyltransferase activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with TRMT1: view
genes like me logo Genes that share phenotypes with TRMT1: view

Animal Model Products

miRNA for TRMT1 Gene

miRTarBase miRNAs that target TRMT1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRMT1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for TRMT1 Gene

Localization for TRMT1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRMT1 Gene COMPARTMENTS Subcellular localization image for TRMT1 gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for TRMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
GO:0005739 mitochondrion IBA --
genes like me logo Genes that share ontologies with TRMT1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRMT1 Gene

Pathways & Interactions for TRMT1 Gene

genes like me logo Genes that share pathways with TRMT1: view

Pathways by source for TRMT1 Gene

Gene Ontology (GO) - Biological Process for TRMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002940 tRNA N2-guanine methylation IBA --
GO:0006400 tRNA modification TAS --
GO:0008033 tRNA processing TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with TRMT1: view

No data available for SIGNOR curated interactions for TRMT1 Gene

Drugs & Compounds for TRMT1 Gene

(2) Drugs for TRMT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0
genes like me logo Genes that share compounds with TRMT1: view

Transcripts for TRMT1 Gene

Unigene Clusters for TRMT1 Gene

TRNA methyltransferase 1 homolog (S. cerevisiae):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRMT1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ·
SP1: - - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - - - - - - - - - - - -
SP5:
SP6: - - - - - - - -
SP7: - - - - - -
SP8: - - - - - - -
SP9: - - - - -
SP10:
SP11:
SP12: - - - - - - - - -
SP13:
SP14: - - - - -
SP15: - - - - - - - -
SP16: - - - - - - - - - - -
SP17: - - -
SP18:
SP19: - - - -
SP20: - - - - -
SP21: - - - -
SP22: - - - - - -
SP23: - - - - - - - - -
SP24: - -
SP25: - - -

ExUns: 7c · 7d ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18
SP1:
SP2:
SP3: -
SP4:
SP5: -
SP6:
SP7: - -
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13: -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:

Relevant External Links for TRMT1 Gene

GeneLoc Exon Structure for
TRMT1
ECgene alternative splicing isoforms for
TRMT1

Expression for TRMT1 Gene

mRNA expression in normal human tissues for TRMT1 Gene

Protein differential expression in normal tissues from HIPED for TRMT1 Gene

This gene is overexpressed in Lung (52.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRMT1 Gene



SOURCE GeneReport for Unigene cluster for TRMT1 Gene Hs.515169

genes like me logo Genes that share expression patterns with TRMT1: view

Protein tissue co-expression partners for TRMT1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRMT1 Gene

Orthologs for TRMT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRMT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRMT1 35
  • 87.46 (n)
  • 88.07 (a)
TRMT1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRMT1 35
  • 87.63 (n)
  • 90.41 (a)
TRMT1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trmt1 35
  • 81.58 (n)
  • 84.62 (a)
Trmt1 16
Trmt1 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRMT1 35
  • 99.44 (n)
  • 99.54 (a)
TRMT1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trmt1 35
  • 83.33 (n)
  • 86.81 (a)
oppossum
(Monodelphis domestica)
Mammalia TRMT1 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRMT1 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRMT1 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trmt1 35
  • 66.26 (n)
  • 69.66 (a)
zebrafish
(Danio rerio)
Actinopterygii trmt1 35
  • 65.07 (n)
  • 68.86 (a)
trmt1 36
  • 56 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009740 35
  • 55.46 (n)
  • 51.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6388 35
  • 54.5 (n)
  • 50 (a)
CG6388 36
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea trm-1 35
  • 46.91 (n)
  • 44.4 (a)
trm-1 36
  • 39 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR075W 35
  • 47.88 (n)
  • 39.84 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F19404g 35
  • 45.48 (n)
  • 37.62 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM1 35
  • 45.81 (n)
  • 40.4 (a)
TRM1 36
  • 34 (a)
OneToMany
TRM1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G15810 35
  • 49.14 (n)
  • 43.25 (a)
rice
(Oryza sativa)
Liliopsida Os.14753 35
Os03g0786700 35
  • 50.5 (n)
  • 44.51 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06336 35
  • 47.91 (n)
  • 40.98 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes trm1 35
  • 46.86 (n)
  • 44.31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6910 36
  • 46 (a)
OneToMany
Species with no ortholog for TRMT1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRMT1 Gene

ENSEMBL:
Gene Tree for TRMT1 (if available)
TreeFam:
Gene Tree for TRMT1 (if available)

Paralogs for TRMT1 Gene

Paralogs for TRMT1 Gene

Pseudogenes.org Pseudogenes for TRMT1 Gene

genes like me logo Genes that share paralogs with TRMT1: view

Variants for TRMT1 Gene

Sequence variations from dbSNP and Humsavar for TRMT1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2240659 -- 13,111,024(+) ACAGC(A/G)TTTCC intron-variant
rs7256309 -- 13,106,883(+) agtgg(C/T)gctat intron-variant
rs7256409 -- 13,106,891(+) tatct(C/T)ggctc intron-variant
rs9783945 -- 13,114,668(+) aaaaa(A/T)aaata intron-variant
rs10407727 -- 13,108,494(+) cgcca(C/T)gttga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRMT1 Gene

Variant ID Type Subtype PubMed ID
nsv911082 CNV Loss 21882294
nsv911086 CNV Loss 21882294
nsv911087 CNV Loss 21882294
dgv3735n71 CNV Loss 21882294
nsv911090 CNV Loss 21882294
dgv3736n71 CNV Loss 21882294

Variation tolerance for TRMT1 Gene

Residual Variation Intolerance Score: 16.61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.81; 34.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRMT1 Gene

HapMap Linkage Disequilibrium report
TRMT1
Human Gene Mutation Database (HGMD)
TRMT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRMT1 Gene

Disorders for TRMT1 Gene

Relevant External Links for TRMT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRMT1
genes like me logo Genes that share disorders with TRMT1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRMT1 Gene

Publications for TRMT1 Gene

  1. The human tRNA(m22G26)dimethyltransferase: functional expression and characterization of a cloned hTRM1 gene. (PMID: 10982862) Liu J. … Straby K.B. (Nucleic Acids Res. 2000) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  5. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 67

Products for TRMT1 Gene

Sources for TRMT1 Gene

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